Medicine injector and replaceable cartridge thereof

Abstract

To provide a medicine injector including an applicator including a cartridge reception receptacle, and a replaceable cartridge containing a medicine that has been loaded in advance.SOLUTION: A cartridge 90 includes a barrier member 108 having a close position of inhibiting access to a medicine. The barrier member 108 is movable from the close position to an open position that can be accessed via an applicator 42 for administration by inserting the cartridge 90 into a receptacle 70. When the medicine is delivered and the cartridge 90 is detached from the receptacle 70, the barrier member 108 moves so as to automatically return to the close position. As a result, according to a medicine injector 40 for use in various clinical scenes, a plurality of medicine cartridges 90 to which loading had been performed in advance can be selected on-demand when needed in order to improve versatility, safety, and speed of medicine delivery in an emergency status.SELECTED DRAWING: Figure 10

Description

[Technical Field]

[0001] The present invention relates to a pharmaceutical syringe and a replaceable cartridge assembly thereof. is configured to selectively receive a variety of replaceable drug-carrying cartridges. Regarding syringes. [Background technology]

[0002] U.S. Patent No. 5,929,999 to Schmid et al. discloses an adjustable injection device for administering drugs. The device described above includes a housing having an array of fastening points and a fastening device attached to the housing. Each of the devices has at least one holding device and at least one blocking device for The holding device of the first shell is attached to a fixed point. and the retention device on the second shell can be attached to a further fixing point. The retaining device of the first shell is removed therefrom by the blocking device of the second shell. The holding device of the second shell is designed to prevent the blocking device of the further shell. or the injection device is separated into two external If the device only has a shell, it can be removed from further fixing points by the blocking device of the first shell. This prevents the outer shell from being detachably connected to the housing.

[0003] Patent Document 2 by Lev discloses a replaceable, liquid-containing device for administering a liquid drug to a patient. The present inventors have disclosed an electronic autoinjector device for use with certain pre-filled cassettes. The autoinjector device is manually operated by sliding the cassette into and out of the device. an autoinjector housing including a cassette holder open at the end for removal as described above; The electronic autoinjector device described above also includes a handheld pen-like electronic autoinjector. a base including a storage recess for closely receiving the electronic autoinjector when not in use; a remote control unit having a cover for closing the base; and an electronic autoinjector device. and a user control interface for operating the device.

[0004] US Patent No. 5,999,999 to Lev discloses a syringe assembly for automatically delivering a predetermined dose of a drug to a subject. The assembly is adapted to actuate an actuator to initiate automatic delivery of the dose of medication. The assembly includes a distal end of the syringe assembly configured to pass a needle through the distal end of the syringe assembly. The above-described assembly includes a needle opening at the distal end thereof for applying pressure to the plunger assembly. a plunger drive mechanism for actuating the actuation switch; a motor connected to the plunger and an actuator operably connected to the motor and plunger assembly; The above-described assembly includes at least one removable cartridge module. a surface for operatively connecting to at least a portion of said removable cartridge module; The module includes a needle housing to define the range of possible injection depths. a plunger housing for aligning the plunger assembly with the plunger drive mechanism; The above-described assembly may involve pre-filled cartridges and / or medications contained therein. an identification element containing a code and a seal for securing the pre-filled cartridge back in place; The assembly described above includes a removable cartridge module attached to the surface described above. The assembly includes at least one engagement portion for securing the syringe assembly to the proximal end of the syringe assembly. a cart for axially moving a pre-filled cartridge between the distal and distal ends; The cartridge drive assembly includes a motor and an actuation switch. The gear element includes at least one gear element operably connected to the gear element.

[0005] Medication is administered by drawing the drug into a syringe and injecting it with a needle or through an intravenous line. It is cumbersome because it requires multiple parts and multiple steps to deliver it to the patient by injection. The above steps involved in the delivery of the drug are syringe / plunge This includes the use of a combination of needles, needles, and medications. Healthcare providers should use the appropriate It is necessary to deliver the appropriate drug at the appropriate dose. Furthermore, the common delivery route is IM (intramuscular). ), IV (intravenous), IN (intranasal), and IO (intraosseous) routes. Considering the various steps, this can result in significant delays and manipulations that could have harmful consequences for the patient. Pre-hospital / transport medical care, aerospace medical care non-hospital medical care, such as bystander first aid and military medical care. In the floor area, the benefits of reduced bulk / parts, increased versatility, and ease of use are also important. Therefore, selective and standardized exchanges are required depending on clinical needs and circumstances. A versatile medication syringe that seamlessly interfaces with any medication cartridge It may be necessary to use [Prior art documents] [Patent documents]

[0006] [Patent Document 1] US Patent Application Publication No. 2018 / 0126083 [Patent Document 2] International Publication No. 2013 / 065055 [Patent Document 3] International Publication No. 2016 / 210404 Summary of the Invention [Problem to be solved by the invention]

[0007] The present invention provides an improved drug syringe and its replaceable cartridge, It is an object to provide a syringe and its replaceable cartridge. [Means for solving the problem]

[0008] Accordingly, in a first aspect, there is provided a drug injector. The above-mentioned drug syringe includes an applicator having a ridge-receiving receptacle. a replaceable cartridge having a body shaped to receive or contain a drug in the cartridge; The cartridges described above include at least one cartridge having a closed position that prevents access to the drug. The barrier member is configured to be in the closed position and to be in the open position. When the cartridge is inserted into the cartridge receiving receptacle, the drug is applied to the applicator via the applicator. The barrier member is movable to an accessible open position. When removed from the edge receiving receptacle, the latch moves back to the closed position.

[0009] The present invention also provides a drug injector according to a second aspect. The drug injector includes a cartridge. The drug syringe includes an applicator having a receiving receptacle. a replaceable cartridge having a body configured to receive or contain the agent; The cartridge includes a valve coupled to the body. The valve is then inserted into the cartridge receiving receptacle to allow the drug from a closed position that prevents access to the drug through the applicator to an open position that allows access to the drug through the applicator. The actuator operates to move the actuator to the release position.

[0010] Also, a third aspect of the present invention provides a drug syringe. The drug syringe includes a needle. The above-mentioned drug injector includes a cartridge-receiving receptacle connected to a needle. The drug syringe is a replaceable cartridge that is pre-filled, contains, or receives the drug therein. The cartridge described above has a pre-injection mode that blocks access to the drug. The cartridge is inserted into the cartridge receiving receptacle. The ridge moves from a pre-injection mode to an injection mode in which the medication is accessible through the needle.

[0011] A kit containing multiple replaceable cartridges containing variable medication and one of the medication syringes described above. Further information is provided.

[0012] There is still further provided a drug injector in a fourth aspect. The drug injector as described above comprises a cartridge. The above-mentioned medication syringe includes an applicator having a pre-filled syringe receiving receptacle. The drug delivery device includes a plurality of replaceable cartridges containing a predetermined amount of one or more drugs. The launcher inserts one of the selected cartridges described above into the cartridge receiving receptacle. The drug contains a reversible barrier mechanism that prevents access to the drug until

[0013] The present invention will now be described in detail with reference to the accompanying drawings, in which: This is more easily understood from the description. [Brief explanation of the drawings]

[0014] [Figure 1] FIG. 1 is a side view of one embodiment of a drug injector including an applicator and a replaceable drug holding cartridge positioned above the applicator, the applicator including a plunger adjacent a first end thereof and a protective needle assembly extending around a needle (not shown) adjacent a second end thereof, the cartridge including a hollow body and a valve pivotally coupled to the body, the valve including a valve actuator shown in a closed position. [Figure 2] FIG. 2 is a side view of the medication injector of FIG. 1, with the applicator and cartridge described above shown in cross section to show their interior. [Figure 3] 3 is a top, side perspective view of the pharmaceutical syringe of FIG. 1. FIG. [Figure 4] 4 is a perspective view of the cartridge of FIG. 1 from its plunger insertion end, showing a portion of the cartridge-receiving receptacle of the applicator of FIG. 1; FIG. [Figure 5] 5 is a perspective view of the cartridge of FIG. 1 from its valve actuator end, showing a portion of the cartridge-receiving receptacle of the applicator of FIG. 1; FIG. [Figure 6] 6 is a bottom, side perspective view of the cartridge of FIG. 1, showing a portion of the cartridge-receiving receptacle of the applicator of FIG. 1; FIG. [Figure 7] 7 is a bottom, side perspective view of the cartridge of FIG. 1, showing a portion of the cartridge-receiving receptacle of the applicator of FIG. 1, with the cartridge valve actuator partially actuated. [Figure 8] 8 is a bottom, side perspective view of the cartridge of FIG. 1, showing a portion of the cartridge-receiving receptacle of the applicator of FIG. 1, with the cartridge valve actuator fully actuated. [Figure 9] FIG. 9 is a side view of the medication injector of FIG. 1 showing the cartridge described above in the process of being inserted into a cartridge-receiving receptacle of an applicator via the plunger insertion end of the cartridge. [Figure 10] 10 is a side perspective view of the drug injector of FIG. 9, with the applicator and cartridge shown in cross section to show the interior thereof, and the drug injector further including a retention member having a catch and shown in an extended position, with a protrusion on the plunger insertion end of the cartridge engaging the catch. [Figure 11] FIG. 11 is a side view of the medication injector of FIG. 1 showing the cartridge as described above further inserted into the cartridge-receiving receptacle of the applicator, with the valve actuator abutting an upper portion of the ramp of the applicator. [Figure 12] FIG. 12 is a side perspective view of the drug injector of FIG. 10, with the applicator and cartridge described above shown in cross section to show the interior thereof. [Figure 13] 13 is an enlarged side view of the drug syringe of FIG. 1 partially shown and cross-sectionally shown to show its interior, without showing the valve actuator, showing the valve body of the valve further inserted into the cartridge-receiving receptacle than in FIG. 12, and showing the valve in its closed position. [Figure 14] FIG. 14 is a side perspective view of the medication injector of FIG. 1 showing the cartridge as described above inserted further into the cartridge-receiving receptacle compared to FIG. 13, with the valve actuator beginning to enter the cartridge-receiving receptacle and the applicator ramp actuating the valve actuator to move the valve from its closed position to its open position. [Figure 15]15 is an enlarged side view of the drug syringe of FIG. 14 with a portion shown and a cross-section shown to show its interior, without showing the valve actuator and showing the valve body of the valve closer to the cartridge-receiving receptacle than in FIG. 14. [Figure 16] FIG. 16 is a side view of the medication injector of FIG. 1 showing the cartridge described above fully inserted into the cartridge-receiving receptacle of the applicator. [Figure 17] 17 is a side view of the drug injector of FIG. 16 , with the applicator and cartridge shown in cross section to show their interiors, with the retaining member in its retracted position holding the cartridge in place, the plunger insertion end of the cartridge connecting with the applicator plunger, the valve in an open position to communicate the interior of the cartridge with the applicator needle conduit, and the applicator detent engaging a complementary recess in the cartridge valve body to further hold the cartridge in place. [Figure 18] 18 is a side view of the medication syringe of FIG. 17 showing the needle inserted into a patient, the protective needle assembly shown in the retracted position, and the plunger shown in the primed position. [Figure 19] FIG. 19 is a side view of the medication injector of FIG. 18, with the plunger shown in the injection position to direct medication from within the cartridge, through the valve body, the medication delivery end of the cartridge, through the conduit of the applicator, out the needle and into the patient. [Figure 20] FIG. 20 is a top, front, right-side exploded view of a medicine syringe according to the second embodiment. [Figure 21A] 21A is a front view of the depressor of the medication syringe of FIG. 20. FIG. [Figure 21B] 21B is a top, front, right-side view of the hold-down tool of FIG. [Figure 21C] 21C is a right side view of the depressor of FIG. 20. FIG. [Figure 21D]FIG. 21D is a cross-sectional view of the pusher of FIG. 21E taken along line 21D-21D. [Figure 21E] 21E is a plan view of the pusher of FIG. 20. FIG. [Figure 22A] 22A is a front view of the depressor housing of the medication syringe of FIG. 20. FIG. [Figure 22B] 22B is a top, front, right-side view of the hold-down housing of FIG. 20. FIG. [Figure 22C] 22C is a right side view of the hold-down tool housing of FIG. 20. FIG. [Figure 22D] 22D is a top view of the hold-down tool of FIG. 20. FIG. [Figure 22E] FIG. 22E is a cross-sectional view of the pusher of FIG. 22F taken along line 22E-22E. [Figure 22F] 22F is a rear view of the depressor housing of the medication syringe of FIG. 20. [Figure 22G] 22G is a top, back, right side view of the depressor housing of the medication syringe of FIG. 20. [Figure 23] FIG. 23 is a plan, front, right-side exploded view of the medication injector of FIG. 20 showing the pusher housing fully assembled and extending around the pusher, and showing the pusher housing in the process of connecting to the cartridge-receiving receptacle. [Figure 24] FIG. 24 is a plan, front, right-side exploded view of the medication injector of FIG. 23 showing the pusher housing coupled to the cartridge-receiving receptacle, and further including a replaceable cartridge shown in the process of being removed from the cartridge-receiving receptacle. [Figure 25A] 25A is a front view of the cartridge-receiving receptacle of FIG. 23. FIG. [Figure 25B] 25B is a top, front, right-hand view of the cartridge-receiving receptacle of FIG. 23. FIG. [Figure 25C] FIG. 25C is a cross-sectional view of the cartridge receiving receptacle of FIG. 25D taken along line 25C-25C. [Figure 25D] 25D is a right side view of the cartridge-receiving receptacle of FIG. 23. FIG. [Figure 25E] 25E is a top view of the cartridge-receiving receptacle of FIG. 23. FIG. [Figure 26] 26 is a plan, front, right-side exploded view of the drug injector of FIG. 23 showing the cartridge fully removed from the cartridge-receiving receptacle to reveal its first valve, and the cartridge-receiving receptacle partially shown to reveal its internal contents including its second valve, which includes a valve housing and a valve body disposed within the valve housing. [Figure 27A] 27A is a left, bottom, rear perspective view of the valve housing of the second valve of FIG. 26. FIG. [Figure 27B] FIG. 27B is a right side view of the valve housing of FIG. 27A. [Figure 27C] FIG. 27C is a top view of the valve housing of FIG. 27A. [Figure 27D] FIG. 27D is a left side view of the valve housing of FIG. 27A. [Figure 27E] FIG. 27E is a front, bottom, left perspective view of the valve housing of FIG. 27A. [Figure 27F] FIG. 27F is a front view of the valve housing of FIG. 27A. [Figure 28A] 28A is a bottom, right, front perspective view of the valve housing of the second valve of FIG. 26. FIG. [Figure 28B] FIG. 28B is a top view of the valve housing of FIG. 28A. [Figure 28C] FIG. 28C is a right side view of the valve housing of FIG. 28A. [Figure 28D] FIG. 28D is a bottom, right, rear perspective view of the valve housing of FIG. 28A. [Figure 28E] FIG. 28E is a front view of the valve housing of FIG. 28A. [Figure 29] FIG. 29 is a top, right, front exploded view of the cartridge of FIG. 26, including the body, the barrel containing the medicament, and the retaining member shown in the unlocked position. [Figure 30A]30A is a plan view of the main body of the cartridge of FIG. 29. FIG. [Figure 30B] FIG. 30B is a left side view of the main body of the cartridge of FIG. 30A. [Figure 30C] FIG. 30C is a bottom, front, right-side perspective view of the body of the cartridge of FIG. 30A. [Figure 30D] FIG. 30D is a front view of the main body of the cartridge of FIG. 30A. [Figure 30E] FIG. 30E is a rear view of the main body of the cartridge of FIG. 30A. [Figure 31A] 31A is a rear view of the holding member of FIG. 20. FIG. [Figure 31B] FIG. 31B is a plan view of the retaining member of FIG. 31A. [Figure 31C] FIG. 31C is a left side view of the retaining member of FIG. 31A. [Figure 31D] FIG. 31D is a front, bottom, left perspective view of the retaining member of FIG. 31A. [Figure 31E] FIG. 31E is a front view of the retaining member of FIG. 31D. [Figure 32A] 32A is a front, top, right-side perspective view of the cartridge of FIG. 29, showing the retaining member in the locked position. [Figure 32B] FIG. 32B is a front, top, right-hand perspective view of the cartridge of FIG. 29 showing the retaining members in a partially unlocked position. [Figure 32C] 32C is a front, top, right-hand perspective view of the cartridge of FIG. 29, with the retaining member shown in a fully unlocked position and spaced apart from the body of the cartridge. [Figure 33A] FIG. 33A is an enlarged view of a portion of a cartridge-receiving receptacle showing its linear set of teeth, showing a first valve and a second valve in a closed position, each valve having a circular gear, the gear of the second valve in the process of engaging with the teeth of the cartridge to move the second valve from its closed position to its open position. [Figure 33B]FIG. 33B is an exploded view of the medication syringe in the same position as FIG. 33A, with the cartridge in the process of being inserted into the cartridge-receiving receptacle, showing a cross section of the valve in its closed position. [Figure 34A] FIG. 34A is an enlarged view of a portion of the cartridge-receiving receptacle with the teeth located between the first and second valves, the second valve now in a closed position, and the gear of the first valve in the process of engaging the teeth of the cartridge to move the first valve from its open position to its closed position. [Figure 34B] FIG. 34B is an exploded view of the medication injector in the same position as FIG. 34A, with the cartridge in the process of being inserted into the cartridge-receiving receptacle, showing a cross-sectional view of the valves to show the second valve in its open position and the first valve in its closed position. [Figure 35] FIG. 35 is a side view of the medication injector of FIG. 20 showing a cartridge fully inserted into a cartridge-receiving receptacle, the medication injector including a needle assembly coupled to a pusher, the pusher in a pre-injection mode such that the needle assembly is spaced in front of a barrel containing the medication. [Figure 35] FIG. 35 is a side view of the medication injector of FIG. 20 showing a cartridge fully inserted into a cartridge-receiving receptacle, the medication injector including a needle assembly coupled to a pusher, the pusher in a pre-injection mode such that the needle assembly is spaced in front of a barrel containing the medication. [Figure 36] FIG. 36 is a side view of the medication injector of FIG. 35 shown in an injection mode with the pusher partially depressed toward the cartridge-receiving receptacle and the needle assembly extending into the barrel and in communication with the medication. [Figure 37] FIG. 37 is a side view of the medication injector of FIG. 36 shown in the injection mode with the pusher fully depressed toward the cartridge-receiving receptacle and the needle assembly further extending fully into the barrel and in communication with the medication. [Figure 38]FIG. 38 is a side view of the medicine syringe according to the third embodiment. [Figure 39] FIG. 39 is an exploded view of the back, right side of the fourth embodiment of the medication injector, with its replaceable cartridge shown spaced rearward from its cartridge-receiving receptacle, including the depressor shown with the medication injector in a pre-injection mode. [Figure 40] FIG. 40 is a front, right side exploded view of the drug syringe of FIG. [Figure 41] FIG. 41 is a plan view thereof. [Figure 42] FIG. 42 is a plan view similar to FIG. 41 of the medication injector of FIG. 39 with the top half of its cartridge-receiving receptacle removed to show its internal components. [Figure 43] 43 is a top view of the medication injector of FIG. 39 with its pusher, pusher housing, cartridge-receiving receptacle, and the top half of the cartridge retaining member removed to show its internal components. [Figure 44] FIG. 44 is a top view of the medication injector of FIG. 43 with its pusher, pusher housing, cartridge-receiving receptacle, and the top half of the cartridge retaining member removed to show its internal components, and with its replaceable cartridge in the process of being inserted into the cartridge-receiving receptacle. [Figure 45] FIG. 45 is a top view of the medication injector of FIG. 44 with its pusher, pusher housing, cartridge-receiving receptacle, and the top half of the cartridge retaining member removed to show its internal components, with a replaceable cartridge shown fully inserted into the cartridge-receiving receptacle. [Figure 46]FIG. 46 is a top view of the medication injector of FIG. 45 with its pusher, pusher housing, cartridge-receiving receptacle, and the top half of the cartridge retaining member removed to show its internal components, with a replaceable cartridge shown fully inserted into the cartridge-receiving receptacle, and the pusher partially retracted toward the cartridge-receiving receptacle and moved toward injection mode to expose the distal needle of the needle assembly, which is in communication with the medication in the replaceable cartridge. [Figure 47] 47 is a plan view of a portion of the medication injector of FIG. 46 with its pusher, pusher housing, cartridge-receiving receptacle, and the top half of the cartridge retaining member removed to show its internal components, with a replaceable cartridge shown fully inserted into the cartridge-receiving receptacle and the pusher further fully depressed toward the cartridge-receiving receptacle, showing the valve, valve housing, pusher, and pusher housing of the medication injector moving toward the cartridge as the medication is emptied therefrom; [Figure 48] FIG. 48 is a plan view of a portion of the medication injector of FIG. 47 with its pusher, pusher housing, cartridge-receiving receptacle, and the top half of the cartridge retaining member removed to show its internal components, with the medication fully emptied from the barrel and a tapered member of one of the pusher housings in the process of removing the cartridge retaining member, and thus the cartridge, from the cartridge-receiving receptacle. [Figure 49] FIG. 49 is a plan view of a portion of the medication injector of FIG. 48 with its pusher, pusher housing, cartridge-receiving receptacle, and the top half of the cartridge retaining member removed to show its internal components, showing the tapered members of the pusher housing biasing the catch members of the cartridge retaining member more fully radially inward to remove the cartridge retaining member more fully from the cartridge-receiving receptacle. [Figure 50]FIG. 50 is a plan view of a portion of the medication injector of FIG. 49 with its pusher, pusher housing, cartridge-receiving receptacle, and the top half of the cartridge retaining member removed to show its internal components, and showing the cartridge retaining member and emptied, replaceable cartridge removed and spaced apart from the cartridge-receiving receptacle. DETAILED DESCRIPTION OF THE INVENTION

[0015] Referring now to the drawings, and initially to FIG. 1, a medication syringe 40 is shown.

[0016] The medication syringe is at least partially hollow and extends along a longitudinal axis 43. The applicator includes a cartridge applicator 42, which is a generally cylindrical body. The depressor, in this example, includes a plunger 44 adjacent its first end 46. As shown in FIG. As such, the plunger described above has a first or outer end, in this example a gripping end 39, and a second or outer end. The plunger 44 has an inner end, in this example a distal end 41. The plunger 44 is the same as the loading device shown in FIG. 2, the applicator can be moved from the injection position shown in FIG. 42 is a push-down tool hole, which in this embodiment is offset from the axis 43 and is parallel to the axis 43 in this example. The plunger hole 45 in this example extends along the length of the application. Extending to the end 46 of the rotor, the plunger 44 is adapted to slidingly receive the plunger 44 therein. It has a shape.

[0017] The applicator 42 includes a needle guard assembly 48 adjacent its second end 50. The needle guard assembly selectively extends around the needle 52 shown in Figures 18 and 19. In this regard, The components and functions of an example of a suitable needle protection assembly are described in U.S. Provisional Patent Application No. 16 / 800,800. No. 4, the disclosure of which is incorporated herein by reference. Claims priority of.

[0018] Referring to FIG. 2, the applicator 42 is configured to couple to the needle 52 of FIG. As shown in FIG. 15, the conduit portion 53 includes a first end (not shown) that is The conduit has a second end 55. The conduit has at least one male member and at least one female member. In this example, the male members include one of the male members, in this case the circumferential return loops 54 spaced apart in the direction of the return loop, each having a catch 59 extending radially inward in this example; Includes a stopper 57.

[0019] Returning to FIG. 1, the applicator 42 has a sidewall, in this example annular sidewall 54, and a ridge, This example includes a lamp 56 coupled to and extending outwardly from the side wall. The pump is generally triangular in shape in this example when viewed from the side, with applicator end 46 and end 5 0. The ramp 56 has a thin end 58 adjacent the side wall 54 of the applicator 42. and a larger or thicker portion spaced further radially from the sidewall of the applicator. 4, the ramp 56 has a recessed track 62 thereon. The recessed track 62 includes a pair of spaced apart recessed shoulders 64 and 66. A further recessed, centrally located channel 68 extends between shoulders 64 and 66 .

[0020] As shown in FIG. 10, the applicator 42 has a cartridge between its end 46 and end 50. 19, includes a ridge receiving receptacle 70. As shown in FIG. The receptacle is connected to a needle 52. Returning to FIG. 10, the cartridge receiving receptacle The tackle passes through the annular side wall 54 of the applicator and is generally rectangular in shape in this example. The cartridge receiving receptacle 70 has an opening 72 which is It is located between the cap 56 and the plunger hole 45 and communicates with the plunger hole. The receiving receptacle is oriented parallel to the longitudinal axis 43 of the applicator 42 in this example. 3 and 15, the cartridge receiving receptacle 70 extends to In the example, the lamp 56 has an enlarged portion 73 adjacent to it. The enlarged portion, in this case, has a generally annular shape. It is in this state.

[0021] As shown in FIG. 15, the applicator 42 is fitted into a cartridge receiving receptacle 70. 16. The applicator shown in FIG. 16 is connected to the lamp 56 and extends between the end 46. 15, the track described above is generally rectangular in shape in this example. shaped and extends parallel to the longitudinal axis 43 of the applicator 42.

[0022] As shown in Figure 12, the drug syringe 40 includes a cartridge retaining member 76. The support member is connected to the inner track 7 of the applicator 42 via an inverted U-shaped bottom 78 in this example. 4. The retaining member is elongated in this example and is shaped to slidably engage with the The retaining member 76 extends parallel to the longitudinal axis 43 of the catcher 42. One of them, in this example, has a catch 8 connected to its upper part 82 and extending upward from the upper part 82. Includes 0.

[0023] As shown in FIG. 2, the retaining member 76 is configured such that the catch described above is supported by a resilient member, in this example a spring 8 4 into the cartridge-receiving receptacle 70 toward a closed or extended position. The spring has a first end 8 abutting the applicator 42 in this example. 6 adjacent the distal end 41 of the plunger 44, in this example along the internal track 74 The spring 84 has a second end 88 that abuts the retaining member 76.

[0024] The retaining members move along the internal tracks 74 from the extended position shown in FIG. 2 to the open position shown in FIG. When the retaining member is in its retracted position, the catch 80 away from the cartridge receiving receptacle 70.

[0025] Referring to FIG. 1, the drug syringe 40 includes a replaceable cartridge 90 as shown. The cartridges include a plurality of replaceable cartridges. Referring to FIG. 2, the cartridge 90 has an interior 94 The cartridge is an elongated cartridge having a hole 98 for containing and receiving the drug. 17, the elongated body 96 holds the cartridge 90 in place. When fully inserted into cartridge-receiving receptacle 70, applicator 42 extends longitudinally. It extends parallel to the adaxial axis 43 .

[0026] Referring to FIG. 1, the cartridge has an angled first end, in this example a plastic 4, the cartridge has a plunger insertion end 100. The end is in the shape of an isosceles trapezoid in this example and has an opening 102. Referring to FIG. , the hole 98 is inserted through an opening 102 in a plunger insertion end 100 of the cartridge 90 . It is shaped to slidingly receive the distal end 41 of the plunger 44. Upon return, the cartridge catches one of the catches or protrusions, in this example protrusion 104. In this example, the protrusion has a substantially rectangular parallelepiped shape.

[0027] As shown in FIG. 13, the cartridge 90 includes a piston member, in this example, a bore 98 therein. The piston 106 is arranged to be sealable. longitudinally movable and extending through an opening 102 in the plunger insertion end 100 of the cartridge. and the interior 94 of the cartridge.

[0028] As shown in FIG. 1, cartridge 90 includes a barrier member, in this example at its drug delivery end 1. 10. The piston 106 mentioned above is inserted into the end 100 of the cartridge. and end 110. The valve 108 is located in the body 96 of the cartridge 90. It is pivotally connected and therefore rotatable relative to the body 96 .

[0029] The valve is pivotally coupled to a valve actuator, in this example the body of the cartridge. The lever 111 has an oval shape in this example when viewed from the side. As shown in FIG. 15, the valve 108 is a valve having a substantially cylindrical shape when viewed from the side in this example. The valve includes a body 114. The valve is arc-shaped in this example and has a through-hole through the valve body. The valve 108 includes a conduit portion 116. The conduit portion of the valve 108 has an inlet 118 and an outlet 120. The lug is a member shaped to engage a detent, in this example the outlet 12 of the conduit section 116. 7, the recesses described above include recesses 122 in the valve body 114 adjacent to the recesses 122. In this example, it is circular.

[0030] 1 and 2, the valve 108 is inserted between the hollow body 96 of the cartridge 90 and the drug The cartridge has a closed position that prevents communication between the drug delivery end 110 and the injection end 110. pre-injection mode, and therefore when cartridge 90 is in pre-injection mode, the valve 1, blocking access to the drug 92. As shown in FIGS. 13 and 15, When the nozzle 108 is in its closed position, the inlet 118 of the conduit portion 116 and the interior 9 of the cartridge are 4. As shown in FIG. 1, the valve is in its fully closed position in this example. When in the valve position, the valve and its lever 111 are substantially flush with the body 96 of the cartridge 90. extend parallel.

[0031] Referring to FIG. 10, the cartridge 90 is inserted into the cartridge receiving lever of the applicator 42. To insert the cartridge 90 into the receptacle 70, the protrusion 104 of the cartridge 90 is first inserted into the holding member 7 Engage catch 80 at 6.

[0032] As shown in FIG. 11, lever 111 is then inserted into the recessed track of ramp 56 of the applicator. The cartridge 90 is then placed against the recessed track 62 and slid along the recessed track 62. 11. As shown by the arrow 124, the valve is moved to the right from the state shown in FIG. 108 is slid down the ramp toward the cartridge receiving receptacle 70. This rightward movement of the cartridge causes the retaining member 76 to move to its extended position shown in FIG. 19 to its retracted position, which moves the cartridge 90 1. The cartridge receiving receptacle 70 provides space for insertion.

[0033] 1, 14, and 16, the lamp 56 is connected to the lever 111 shown in FIG. It functions to move the valve from its closed position to the open position shown in Figure 16. As shown, when the valve is in its open position, the inlet 118 of the conduit section 116 is connected to the cartridge 9 0, and the outlet 120 of the conduit portion communicates with the conduit portion 53 of the applicator 42. In this way, communication is established between the drug 92 of the cartridge and the drug delivery end 110. Also, with the lever 111 in the fully open position, the applicator detent 57 The recess aligns with the recess in the valve body 114, allowing it to couple with the valve body. Therefore, by inserting the cartridge 90 into the applicator 42, 1 to its open position shown in FIG. 16. 7, the medication 92 is accessible by the applicator. By inserting the cartridge into the ridge receiving receptacle 70, the cartridge is From the pre-injection mode, the patient moves to an injection mode where the drug is accessible through the needle 52 shown in FIG. do.

[0034] Referring to FIG. 17, cartridge 90 is inserted into a cartridge receiving receptacle. By doing so, the plunger insertion end 100 of the cartridge 90 is inserted into the plunger. , and the end abuts against a corresponding tapered portion 126 of the applicator 42. Inserting the cartridge into the cartridge-receiving receptacle further The interior 94 of the cartridge communicates with the drug delivery end 110 of the cartridge. The ridge 90 is inserted into the cartridge receiving receptacle 70 to receive the cartridge. The drug delivery end of the device communicates with the conduit portion 53 of the applicator 42 .

[0035] Referring to FIG. 18, the spring 84 pushes the retainer toward the fully inserted cartridge 90. The material 76 is biased to prevent the cartridge from being removed from the cartridge receiving receptacle. Therefore, the retaining member also fits adequately within the cartridge-receiving receptacle 70. The cartridge is designed so that it cannot be removed once inserted.

[0036] Referring to FIG. 16, for example, lever 111 is moved rearward as shown by the arrow of reference numeral 91. Push to remove cartridge 90 from cartridge-receiving receptacle 70 1. This causes the valve 108 to move from its open position back to its closed position shown in FIG.

[0037] 20 to 37 show a second embodiment of a drug syringe 40.1. 1 to 19. Injector 40.1 is similar to medication syringe 40 as shown in FIGS. 1-19, with the following exceptions: be.

[0038] As shown in Figure 20, the applicator 42.1 includes a needle assembly 128. The needle assembly described above The body uses IM (intramuscular) needle delivery, standard IV (intravenous) tubing and a Luer lock mechanism. and / or IV (intravenous) fluid connection delivery with associated IV (intranasal) drug spray delivery. Also includes a patient-facing portion of the applicator adapted for a variable injection mechanism. The needle assembly 128 extends from the applicator end 50.1 to the applicator. The plunger 44.1 extends towards the plunger 46.1. As shown in Figure 21D, the depressor can be referred to as a pneumatic delivery system. , and has a base 130 extending from its end 41.1 towards its end 39.1. has a hole 131 extending from its end 41.1 toward its end 39.1 and its base. An inner / second hole or passage 132 passes through the base, in this example parallel to the axis 43.1, and 131. The aforementioned passage 132 runs from the hold-down end 41.1 to the hold-down end 39. 1. The push-down tool 44.1 has an extension flange 134 at its end 39.1. The flange has a rectangular parallelepiped shape in this example and is attached to the patient's skin (not shown). The hold-down tool extends between its base 130 and its flange. Both include a sleeve portion 136 that connects the base 130 and the flange together. The sleeve portion is of rectangular cross section in this example, although this is not strictly required. The flange 134 extends radially outward relative to the sleeve portion 136 and the base 130. As shown in FIG. 21E, the pusher 44.1 is connected to at least one guide member, in this example is connected to the base of the hold-down tool adjacent the end 41.1 of the hold-down tool and extends outwardly from the base; It includes a pair of spaced apart projections 138 and 140 .

[0039] As shown in FIG. 21D, the depressors are mounted on a pair of mounts, in this example, located on either side of passage 132. The connector includes a hub 141 that includes an opposed pair of male luer lock fittings 142 and 144 that fit together. Luer lock fittings, including their various parts and functions, are known per se to those skilled in the art, Therefore, it will not be described in further detail. 20 via a female luer lock fitting (not shown). .1, and selectively to the second or inner needle 146 via a female luer lock fitting (not shown). The needles are connected to each other via a passage 132 shown in FIG. 21D. As shown in FIG. 20, the inner and outer needles are therefore pushed by the outer needle 52.1. Extending outward from the lower end 39.1, the inner needle 146 extends outward from the pusher end 41.1. It is connected to the pusher so that it can extend.

[0040] Still referring to FIG. 20, the sleeve portion 136 at least partially covers the outer needle 52. 1, and the needle assembly 128 is therefore at least partially received within the pusher 44.1. Returning to FIG. 21D, the push-down tool 44.1 is positioned adjacent to the luer lock fitting 144. As shown in FIG. 20, the applicator further includes a first resilient portion 148. material, in this example a coil spring whose first end 152 fits within recess 148 shown in FIG. 21D. 150. The coil spring has a second end 153 spaced from its first end. The recess mentioned above is annular in this example and extends from the end 41.1 of the push-in tool 44.2 to the end 41.2 of the push-in tool. Extends towards section 39.1.

[0041] As shown in FIG. 20, the applicator 42.1 includes two parts 156 and 158. The above components include a hold-down tool housing 154. The components include a complementary snap fitting 160 shown in FIG. 22A and 22E, the above-described pusher housing may be closed or internally The depressor housing 154 has a side end 164 and an open, outer end 166. 22E, the passageway 164 extends from the base 168 toward the end 166 of the passageway 164. 170 passes through the base, in this example parallel to axis 43.1. The flange 172 extends from the outer periphery of the rectangular parallelepiped in this example. The hold-down tool housing extends between its base 168 and its flange, and is and a sleeve portion 174 connecting the portion 168 and the flange together. is of approximately rectangular cross section in this example, but this is not strictly required. Flange 172 extends radially outward relative to sleeve portion 174 and base 168 .

[0042] As shown in FIG. 22B, the hold-down tool housing 154 has a hole 45.1 and the sleeve portion 174 a pair of spaced apart walls whose inner surfaces 177 and 179 face each other and communicate with the bore; 22E, the hold-down tool housing includes a pair of inner guides, this The example includes guide channels 180 and 182. The aforementioned hole 45.1 is The projections 138 and 140 are received in the guide channel 180 shown in FIG. 22B. The base 130 and sleeve of the push-down tool 44.1 shown in FIG. 21E are slid along the push-down channel. The spring 150 shown in FIG. 4.1 is biased axially outward relative to the pusher housing to secure the needle 52.1 in the needle protection mode. 14.1 and the base 168 of the hold-down tool 44.1. As shown in Figure 21D, the end 153 of the spring mentioned above abuts against the base of the pusher. As shown, needle assembly 128 is therefore inserted into cartridge receiving receptacle 70.1. and resiliently moves outwardly from the cartridge receiving receptacle 70.1. It is energized.

[0043] The push-down tool is configured such that the push-down tool flange 134 is spaced from the flange 172 of the push-down tool housing 154. It also has a pre-injection position / mode or needle protection mode as shown in Figure 35. The pusher 44.1 is 21E and the guide channel 138 shown in FIG. 22E. 37, which utilizes the needle 52.1 from the pre-injection position of FIG. 35 via the needles 180 and 182. As shown in FIG. 37, flange 1 can be moved linearly to the injection position shown in FIG. 34 and flange 172 abut against each other at the injection position.

[0044] Returning to FIG. 22E, the hold-down tool housing 154 includes a pair of spaced apart outer female locking members, in this example The walls include recessed portions 184 and 186 extending inwardly from outer surfaces 188 and 190 thereof.

[0045] As shown in FIG. 20, the applicator 42.1 is tubular in this example and The cartridge receiving receptacle 70.1 is generally rectangular in cross section. The cartridge receiving receptacle has a first or distal open end 192 and an end of the applicator. and a second or proximal open end 194 that coincides with portion 46.1. The receptacle 70.1 includes a hole 196 extending from its first end to its second end. 4.1 extends outwardly from the distal open end 192 of the cartridge-receiving receptacle 70.1. Drink.

[0046] As shown with respect to Figures 23 and 24, the aperture 196 is a cartridge receiving receptacle. 70.1 is attached to the hold-down housing 154 so that end 192 of the hold-down housing 154 abuts flange 186 of the hold-down housing 154. It is shaped to receive base 168 and sleeve portion 174 of body 154. , the cartridge receiving receptacle is, in this example, The receptacle includes a first wall 202 and a second wall 204, and the first wall 202 and the second wall 204 are connected to each other. a first spaced pair of resilient catch members 1 extending outwardly from the first wall portion 202 and the second wall portion 204; 25C, the pusher housing is selectively coupled to the pusher housing via the pusher housings 98 and 200. The catch member is recessed in the depression housing 154 as shown in FIG. 23 and FIG. 24. 84 includes raised portions 206 and 208 that are shaped to fit within the recessed portion 84.

[0047] As shown in FIG. 25A, the cartridge receiving receptacle 70.1 includes a pair of guides, This example includes spaced apart longitudinally extending projections 209 and 211. See FIG. 25C. The cartridge receiving receptacle is connected to the protrusion and is fitted along the protrusion. The third wall portion includes a third wall portion 226 through which the protrusion extends. 04 and extends between the wall 202 and the wall 204. 211 is a cartridge receiving receptacle near end 192 to the cartridge receiving lever. The protrusions 209 and 211 extend to the end 194 of the receptacle. As shown in FIG. 25A, the cartridge receiving receptacle 70.1 has a wall 2 26. The cartridge-receiving receptacle wall 202 includes a fourth wall 54.1 facing the cartridge-receiving receptacle wall 202. , 204, 226, and 54.1 are each planes in this example.

[0048] As shown in FIG. 25C, cartridge receiving receptacle 70.1 has end 194 A second spaced pair of resilient catch members 210 and 212 are spaced apart from and adjacent end 194. The catch member described above is inserted into the cartridge receiving receptacle through the hole 196 and the inner The ridges 214 and 216 extend partially into the portion 215 .

[0049] As shown in Figure 25C, the applicator 42.1 is connected to a valve actuator, in this example In this example, the linear gears include teeth 223 and 225, a spaced pair of rows 218 of linear gears 112.1 and 222, including teeth 227 and 229; and 220. The linear gear 112.1 is a part of the cartridge receiving receptacle. Adjacent to wall 202, linear gear 222 is positioned against wall 20 of the cartridge-receiving receptacle. 4. The linear gear is adjacent to the end 192 of the cartridge-receiving receptacle 70.1. end 194 and is positioned adjacent to catch members 210 and 212 in this example. Referring to FIG. 25C, the linear gears 112.1 and 222 communicate with the hole 196. In this example, each longitudinally extending projection 209 of the cartridge-receiving receptacle and 211 and extend upwardly from the longitudinally extending projections 209 and 211.

[0050] As shown in FIG. 26, the drug syringe 40.1 includes a first barrier member, in this example a valve 10 8.1. The valve described above includes a valve housing 230, best shown in FIGS. 27A-27F. The valve housing is generally block-shaped in this example, and has a rectangular parallelepiped shape. As shown in 27A, the valve housing has a first or rear end 232 and a second or front end 234. , a top 236, a bottom 238, and a pair of The valve housing 230 includes sides 240 and 242. Along its sides, the valve housing 230 includes a pair of spaced apart lower As shown in FIG. 33A, the valve housing 230 has protruding recessed regions 244 and 246. The car is rotated so that the raised portions 209 and 211 extend into the recessed areas 244 and 246 of the valve housing. 1. The cartridge receiving receptacle 70.1 has a hole 196 shaped to slidably extend therethrough. .

[0051] Returning to FIG. 27A, the valve 108.1 has a through hole through the sides 240 and 242 of the valve housing. and a hole 248 located between the rear end 232 and the front end 234 of the valve housing. As shown in Figure 33A, the holes are perpendicular to the axis 43.1 of the drug syringe 40.1. As shown in FIG. 27E, the valve extends along a transverse axis 249 that is perpendicular to the valve. Another, in this example a pair of spaced apart tracks, in this case the sides 240 and 242 of the valve housing. 42, top 236 and bottom 238, and a recessed chuck located between ends 232 and 234. The channels have arcuate side profiles in this example. and communicate with hole 248. Channels 250 and 252 are of rectangular cross section in this example. do.

[0052] As shown in FIG. 27A, the valve housing 230 has a rear end 232 through which , has a first or rear aperture 254 in communication with the hole 248. As shown in FIG. 27E, The valve housing has a second or front aperture extending through its front end 234 and also communicating with the aperture. The apertures are circular in this example. The front aperture 256 is larger than the rear aperture 254 .

[0053] As shown in Figures 28A-28E, the valve 108.1 is generally cylindrical in shape in this example. The valve body 114.1 includes a valve body 114.1 having spaced apart ends 262 and 264. As shown in FIG. 28E, the valve body includes a pair of circular gears 258 and 260. The conduit portion, in this example, includes a tapered passageway 116.1, which has: In this example, the outlet 120.1 tapers towards the inlet 118.1. The passage extends from the top 266 to the bottom 268 of the valve body, connecting the end 262 of the valve body to the 28B and 28E, the valve body 1 is located between the end 262 and the valve body 1. 14.1 at least one, in this example a pair of spaced apart guides, in this example, FIG. 28B 28E, the valve body is connected to the upper portion 266 of the valve body. Each of the above-mentioned protrusions includes a protrusion 270 and a protrusion 272 extending upward from the The protrusion is located between gear 258 and gear 260, and in this example, is adjacent to the exit 120.1 of the passage 116.1.

[0054] 27A and 28A, the valve body 114.1 is inserted through a hole in the valve housing 230. 248, and protrusions 270 and 272 form the recessed portions shown in FIG. 27E. Fits within and moves relative to recessed channels 250 and 252 Valve 108.1 is shaped to allow for the passage 116 shown in FIG. 28A. 1 does not communicate with the apertures 254 and 254 of the valve housing shown in FIG. 27F; It has a closed position as shown in Figures 33A and 33B.

[0055] Referring to FIG. 33A, valve 108.1 is inserted into cartridge receiving receptacle 70.1. 1. By inserting the gear 258 into the valve 10, the gear 258 and the gear 112.1 engage with each other. 8.1 moves from the closed position shown in FIG. 33B to the open position shown in FIG. 34B. When the valve 108.1 is in the open position, the passage 116.1 extends through the valve housing shown in FIG. 27F. The nozzles 254 and 254 communicate with each other.

[0056] As shown in FIG. 26, the medication syringe 40.1 includes a replaceable cartridge 90.1. The needle 146 extends into the cartridge. As shown in FIG. 35, the valve 108.1 , sandwiched between the needle assembly 128 and the cartridge. The ridge 90.1 includes a barrier member, in this example a valve 108'. 3. The valve 108.1 shown in FIGS. 27A-27F has the same reference numerals as the valve 108.1 shown in FIGS. 27A-27F. 30A and 30C, the valve described above has a valve proximate its end 110.1'. The valve housing includes a valve housing 230'. The valve housing includes a valve housing 230' between its side 240' and side 242'. The valve housing 230' communicates with the hole 248' and 110.1 includes a pair of spaced apart recessed channels 250' and 252' adjacent the end 110.1 of the casing. As shown in FIG. 26, the valve 108.1′ comprises a valve body 114.1 and a valve housing 23 0 and shaped to fit within bore 248' and engage the valve housing. As shown in FIG. 30A, the cartridge 90.1 includes a valve body 114.1'. It includes an aperture 256' that communicates with the hole 248'.

[0057] Referring to FIG. 30C, cartridge 90.1 includes a valve housing 230' integrally connected thereto. The cartridge housing 274 is formed with the cartridge housing 274. Along the sides 240' and 242' are spaced apart pairs of lower recessed regions 244' and 246'. As shown in FIG. 33A, the valve housing 230 has protrusions 209 and 211. Cartridge receiving receptacles are provided to extend into the recessed areas 244' and 246' of the ridge housing. The recess 70.1 is configured to slidably extend within the bore 196 of the receptacle 70.1.

[0058] Referring to Figures 25C and 30C, cartridge 90.1 includes a locking mechanism, in this example selectively fits into a cartridge-receiving receptacle via a snap-fit ​​system The snap fasteners are configured to fit together and connect to the cartridge receiving receptacle. The fit system is fitted with a corresponding outer female locking member, in this example recessed portion 2 shown in FIG. 30A. 25C, which connect to the catch members 212 and 214 shown in FIG. The recessed portions extend inwardly from the sides 240' and 242' of the cartridge housing 274. The cartridge 90.1 is positioned so as to extend from the end 100.1 to the end 110.1. do.

[0059] Referring to FIG. 30A, the cartridge housing 274 is shown at its end 110.1 and end 100. The cartridge 90.1 extends from its open end 100.1 to its end 100.1. 10.1. The bore 276 extends along the axis 43. In the example, the aperture 254 extends perpendicular to the hole 248' and communicates with the hole 248'. As shown in Figure 29, cartridge 90.1 includes a body, in this example containing drug 92.1. As shown in FIG. 33B, the bore 276 is adapted to receive the barrel. It has a shape that allows it to be inserted.

[0060] Returning to FIG. 29, the barrel 96.1 described above has an open first end 278 and a sealed opening 282. The barrel has a second end 280 with a hole 98.1 between its ends. The drug 92.1 is inserted between the piston and the sealing opening 282. The cartridge 90.1 is located within the bore 98.1. The cartridge 90.1 is located within the bore. 278 includes a coil spring 284 extending from end 278 toward end 280. The spring forces the piston 106.1, and therefore the drug 92.1, towards the sealing opening 282. Therefore, the above-mentioned spring 284 applies pressure to the drug. Therefore, the barrel 96.1, the spring 284, and the piston 1 The 06.1 can be described as a spring-loaded delivery system.

[0061] Referring to FIG. 29, the medication syringe 40.1 is biased by the spring 28 against the piston 106.1. 32A. The retaining member 76.1 is configured to selectively couple the end 100.1 of the The retaining member includes an end wall 285 which in this example extends perpendicular to the axis 43.1. 29, the cartridges are each 96.1 mm around the barrel. a pair of spaced apart resilient male members 286 partially extending and having enlarged ends 290; Includes 288.

[0062] As shown in FIG. 32C, the retaining member, in this example, comprises an inner channel 291 and an end wall 285. and inwardly extending catches 292 and 294 that connect to and extend outwardly from end wall 285. As shown in FIG. 32C, the retaining member has a complementary shape in the form of a C having a first It is shaped to enclose the male members 286 and 288 in one angled configuration and in the inserted position. Subsequent rotation of the retaining member, as shown by arrow 293 in FIG. 32B, causes catch 2 92 and 294 into corresponding recesses 296 in male members 286 and 288 in the locked mode. The enlarged end 290 of the male member fits within the inner channel 291 of the retaining member 76.1. The retainer is configured to fit and be enclosed by the inner channel 291. The material 76.1 holds the spring 284 and barrel 96.1 in place within the cartridge housing 274. By reversing the above steps, you can selectively access the barrel as needed. It can be accessed and removed.

[0063] As shown in FIG. 31D, the retaining member 76.1 is connected to a protrusion, in this example the end wall 285. and extends into channel 291 and is configured to fit within open end 278 of barrel 96.1. 298. The knob 298 is centrally located and has a shaped profile.

[0064] As shown in FIG. 31D, the retaining member 76.1 has a spaced apart configuration along its sides 304 and 306. The retaining member has a pair of spaced apart lower recessed regions 300 and 302. As shown in FIG. The cart is secured to the support member such that the protrusions 209 and 211 extend into the corresponding recessed areas 300 of the support member. Ridge shaped to extend partially within bore 196 of receiving receptacle 70.1. To do.

[0065] The above holds the barrel 96.1 in place within the cartridge housing 90.1. This is merely an example of one way to do this and is not strictly required. In this case, the barrel can be held in place, for example, so that it is inaccessible.

[0066] In use, referring to FIG. 33B, in the closed position of the valve 108.1', This prevents communication between cartridge 90.1 and needle assembly 128. When in the pre-injection mode shown, valve 108.1 prevents further access to needle 146. do.

[0067] As shown by arrow 308, cartridge 90.1 is inserted into the cartridge receiving receptacle. By inserting it into the open end 194 of the cartridge 70.1, the cartridge end 110. 1 comes into contact with the valve housing 230 and presses against the valve housing 230. This causes the valve 108.1 to move towards the pusher housing 154. As shown in FIG. , teeth 223 and teeth 225 engage with gear 258 on valve body 114.1, and valve 1 08.1 moves from the closed position shown in FIG. 33B to the open position shown in FIG. 34B. Next, the first barrier to the inner needle 146 is removed.

[0068] Continue inserting cartridge 90.1 into cartridge receiving receptacle 70.1 The teeth 223 and 225 then mate with the gear 258' of the valve 108.1' shown in FIG. 34A. This causes the valve 108.1' to move from the closed position shown in FIG. 34B to the closed position shown in FIG. 92.1.

[0069] As shown by arrow 310 in Figures 34A and 34B, cartridge 90.1 is Further insertion into the cartridge receiving receptacle causes the inner needle to 146 passes through passages 116.1 and 116.1' of valves 108.1 and 108.1'. , the front end 234 of the valve housing 230 abuts the end 164 of the pusher housing 154 .

[0070] Referring to FIG. 35, as shown by arrow 312, flange 13 of push-down tool 44.1 The needle 52.1 is inserted into the patient so that the needle 52.4 abuts against the patient and urges the pusher inward. Thus, the drug is administered to the patient, and the inner needle 146 is sealed, as shown in FIG. It extends through opening 282 into barrel 96.1 to provide access to medication 92.1. Therefore, the cartridge 90.1 is inserted into the cartridge receiving receptacle 70.1. , and then moving the pusher 44.1 from the needle protection mode to an at least partially retracted mode. The inward biasing brings the inner needle into communication with the interior 94.1 of the cartridge. Thus, as shown in FIG. 37, when the needle penetrates the seal opening, the spring-loaded piston The tongs 106.1 urge the drug 92.1 out of the barrel. It is accessible via needle 146 .

[0071] Thus, when the cartridge is fully inserted into the cartridge-receiving receptacle The drug is then accessible via the applicator 42.1. When inserting needle 90.1 into applicator 42.1, needle assembly 128 also inserts medication 90.1 into applicator 42.1. 2.1. The cartridge is inserted into the applicator. The drug is released only when the pusher 44.1 is subsequently actuated. It is done.

[0072] FIG. 38 shows a third embodiment of a drug syringe 40.2. Similar parts are shown in minor parts " The decimal portion ".1" is replaced with ".2" to represent the same symbols and symbols as in the embodiment shown in FIGS. 20 to 37. The drug syringe 40.2 is closed by a pair of sealing members, in this example indicated by arrow 312.2. When the pusher 44.1 is biased inward, the needle 146.2 penetrates the elastic-plastic membrane 3. Medication syringe 40 as shown in FIGS. 20-37, except further including syringes 14 and 316. It is essentially the same as .1.

[0073] Figures 39 to 50 show a fourth embodiment of a drug syringe 40.3. Replace the decimal part ".3" with a decimal part ".1" and add it to parts that didn't previously have a decimal part. In addition, the syringe 40 has the same symbols and functions as the embodiment shown in Figures 20 to 37. .3 is similar to medication syringe 40.1 shown in Figures 20-37 with the following exceptions.

[0074] As shown in FIG. 40, the pusher 44.3 is connected to the sleeve portion 136.3. A central projection 140.3 extends radially outward and upward from sleeve portion 136.3. The protrusions slide into corresponding channels 182.3 in the hold-down housing 154.3. The sleeve portion 136.3 of the push-in tool 44.3 is circular in this example. This is a cross section.

[0075] As shown in FIG. 43, the hold-down device housing 154.3 includes at least one, in this example a pair of, spaced apart resilient catch members 198.3 and 200.3, which are attached to the opposing walls thereof and a half wall extending from the opposing wall portions 176.3 and 178.3. The cartridge receiving receptacle 70.3 has a corresponding recessed portion, In this example, apertures 184.3 are shaped to receive the respective catch members. and 186.3. The pusher housing 154.3 thereby defines a cartridge receiving receptacle. The hold-down tool housing is connected to the open end 192.3 of the receptacle. The hold-down tool housing has a catch member 198.3 and 200.3 radially inward to force the catch members through apertures 184.3 and 186. .3, selectively removable from the cartridge receiving receptacle. be.

[0076] As shown in FIG. 39, the wall 202.3 and 204.3 is substantially planar in this example and is positioned within cartridge receiving receptacle 70. .3 wall 226.3 and extends outwardly at an obtuse angle α relative to said wall 226.3. The cartridge receiving receptacle wall 54.3 is, in this example, wall 202.3 and wall 204.3, extending between said wall 202.3 and said wall 204.3, and having an outwardly convex is.

[0077] As shown in FIG. 44, the pusher 44.3 is directed from its end 41.3 to its end 39.3. The hub 141.3 of the needle assembly 128.3 has an inner bore 132.3 extending therethrough. The pusher 44.3 is received within the inner bore of the pusher and is movable relative to the inner bore. A shoulder 318 extends radially between the side bore 132.3 and the outer bore 131.3. do.

[0078] The medication syringe 40.3 includes a second resilient member, in this example the hub 141 of the needle assembly 128.3. 3 and the shoulder 318 of the pusher. The spring extends in a first direction 333 from the pusher 44.3 towards the cartridge 90.3. Thus, needle assembly 128.3 is biased axially inward by pusher 44. .3 is resiliently biased towards the cartridge.

[0079] As shown in FIG. 43, the drug syringe 40.3 is inserted through a needle guide member, in this example The needle 146.3 includes an axially extending sleeve 322 that selectively receives the needle 146.3. The valve is connected to the valve housing 230.3 in this example and is The sleeve 322 has an integrally formed first or proximal end 324. It has a second or distal end 326 spaced from the end.

[0080] With further reference to Figure 43, the medication syringe 40.3 includes a further elastic member, in this example a cap. A second coil spring 150.3 extends between the cartridge 90.3 and the pusher 44.3. In this example, the spring has a first end that fits into the annular recess 148.3 of the pusher 44.3. The second end 153.3 of the spring 150.3 is, in this example, a sleeve. 45, the cartridge 332 extends around the cartridge 332 and abuts against the valve housing 230.3. When cartridge 90.3 is inserted into cartridge receiving receptacle 70.3, spring 1 50.3 pushes the pusher 44.3 outward from the cartridge 90.3 in the direction 335. To sexually energize.

[0081] As shown in FIG. 39, the valve housing 230'.3 is connected to the cartridge housing 274 in this example. Selectively connect to .3.

[0082] Referring to FIG. 45, the cartridge receiving receptacle 70.3 includes one or more female members. and a first of one or more male members, in this example a spaced pair of female members, in this case each The walls 202.3 and 204.3 include recessed portions 328 and 330 located adjacent to the walls 202.3 and 204.3.

[0083] The cartridge retaining member 76.3 is circular in side view in this example. The member is a second of one or more female members and one or more male members, in this example a spaced apart pair of male members. member, in this case a pair of spaced apart, radially outwardly extending resilient tapered catches 292.3 and The catch described above includes outer surfaces 332 and 334 that are in contact with the applicator 42. a second end 46.3 of the applicator extending from the first end 46.3 of the applicator toward the second end 50.3 of the applicator; In this example, the cross section is triangular so as to be inclined radially inward in the direction 335. The second direction is opposite to the first direction 333. Catches 292.3 and 294.3 are used to protect The support member 76.3 has an end wall 285.3 spaced apart from it, and the projections are spaced apart therebetween. can be.

[0084] Still referring to FIG. 45, the medication syringe 40.3 contains at least one, in this example, spaced apart inner tapered members, in this case extending radially inward, Further included are tapered catches 210.3 and 212.3 on the receptacle 70.3. The catch described above has outer surfaces 336 and 338 that are in contact with the first end 46.3 of the applicator 42.3. in the second direction 335 extending from the second end 50.3 of the applicator toward the second end 50.3 of the applicator. , which in this example has a triangular cross section so as to be inclined radially inward.

[0085] The tapered catches 292.3 and 294.3 of the retaining member 76.3 are shown in Figs. When the cartridge is fully inserted into the cartridge receiving receptacle, as shown in 6, and within respective recessed portions 328 and 330 of cartridge-receiving receptacle 70.3. The cartridge 90.3 is configured to be selectively received in the cartridge receiving When fully inserted into receptacle 70.3, tapered catches 210.3 and 210.4 92.3 and recessed portion 328, tapered catches 212.3 and 294.3 and The recessed portions 330 interengage to remove the cartridge from the cartridge-receiving receptacle. Tapered cap of cartridge receiving receptacle 70.3 210.3 and 212.3 are intended to ensure that the cartridge is fully inserted into the cartridge receiving receptacle. When inserted into the retaining member 76.3, the respective tapered catches 292.3 and 292.4 of the retaining member 76.3 94.3 to selectively engage the tapered catches 292.3 and 294.3. The protrusion 298.3 of the retaining member 76.3 is adapted to hold the cartridge 90.3 in place. Insert fully into receiving receptacle 70.3 and snap into place via the catch When fitted, it, together with spring 150.3, exerts pressure on piston 106.3 to pump drug 92. .3 and configured to apply pressure to barrel 96.3.

[0086] Still referring to FIG. 45, cartridge 90.3 contains at least one, in this example A pair of spaced apart projections or removal members, in this case retaining members adjacent the valve housing 230'.3. tapered member 340 and tapered member 340 opposite catches 292.3 and 294.3 of member 76.3; 342. The tapered member of the cartridge further includes applicator 42 in this example. .3 extending from the first end 46.3 of the applicator towards the second end 50.3 of the applicator. From the second direction 335, the outer surfaces 344 and 346 are inclined radially inwardly, It's not strictly required.

[0087] Insert the cartridge 90.3 into the cartridge receiving receptacle 70.3 and press down 44.3 from the needle protection mode shown in FIG. 45 to the partially retracted mode shown in FIG. When activated, the medication 92.3 communicates with the needle 146.3. By penetrating the piston 106.3, the pressure in the piston is released. is moved in the direction 335 towards the pusher 44.3.

[0088] As shown in FIG. 48, when the pusher 44.3 is moved to the fully retracted mode, the spring 1 50.3 to the tapered catches 292.3 and 294.3 of the retaining member 76.3 The tapered members 340 and 342 of the cartridge 90.3 are biased in the direction of arrow 33 in FIG. As shown by arrows 341 and 339, the catches are bent radially inward. As shown, the recessed portions 328 and 33 of the cartridge-receiving receptacle 70.3 Therefore, the pusher moves to a fully retracted mode, and the hold The catch of member 76.3 is selectively removed from the recessed portion to release cartridge 90.3. , urging the cartridge outward from the cartridge receiving receptacle. When moved to the fully retracted mode, tapered members 340 and 342 form catch 2 92.3 and 294.3, and the catch is inserted into the cartridge receiving receptacle 70. .3 away from catches 214.3 and 216.3. When in its fully retracted mode, the hub 141.1 engages the distal end 3 of the sleeve 322. 26. In this way, the depressor is moved from the partially retracted mode shown in FIG. 48, then cartridge 90.3 is moved to the fully retracted mode. The cartridge is automatically ejected from the receiving receptacle.

[0089] Therefore, cartridge 90.3 is used and discharged from the cartridge receiving receptacle. When the cartridge is removed, the cartridge receiving receptacle 70.3 returns to its natural state and the cartridge is A receiving receptacle can receive an additional cartridge.

[0090] The drug injector as described herein, for example, can be Reducing the number of steps and parts involved in drug delivery reduces the chance of error and improves the Increasing the speed of drug delivery in the In certain circumstances, a medication injector as described herein may be used to administer the medication to a patient. Drug delivery can be made easy and safe while reducing size / bulk. (1) Multi-modular, replaceable, pre-filled, new drug cartridges Introduction of the ji assembly. (2) The cartridges described above are pre-filled with drugs and contain the majority of drugs in all possible situations. and its associated doses are designed to be used. (3) The necessary cartridges selected by healthcare providers in specific demanding clinical situations. The cartridge is then interfaced with a receiving syringe device that receives the cartridge under sterile conditions. Insert the syringe into the device. (4) Once the cartridge is inserted and loaded into the receiving syringe device (facing the patient), Pressure applied to the front of the syringe device forces the medication from the cartridge / syringe device into the patient. A mechanism for delivering the agent is further activated. (5) The user may use the drug cartridge as needed in each given situation / scene. A syringe can be selected and loaded into the syringe device. (6) This makes the entire drug delivery process easier, faster, safer, and more convenient. Reduce the bulk / size of the device being used. (7) Sterility is maintained throughout. This mechanism creates a one-way barrier / sterile seal. It allows the opening action to ensure a sealed sterile space for the drug while injecting it from the loaded cartridge. The drug can be loaded into the device and then injected into the patient. (8) Reduce the cognitive load of simply selecting the cartridge you need and inserting it into the device. This reduces the number of errors. (9) By increasing the speed of drug delivery, delays in administering life-saving medications can be avoided. Cut. (10) First aid administration of epinephrine or opioids in anaphylactic allergies administration of naloxone in steroid overdose or as an antidote for biological / chemical warfare It is easy to use by untrained providers in emergency situations. (11) When drug / device volume is important (e.g., aerospace medicine, hospital reduction in the volume of medical care provided by the military (pre-accident, military / tactical, and bystander) Decreased. (12) When the medication in the pre-filled cartridge is fully administered, the cartridge is inserted into the syringe. The syringe and cartridge are automatically ejected and separated from the device. Return to its original sealed state and, if necessary, further cart the syringe afterwards if necessary. It can be connected to the ridge. (13) The syringe may be used for intravenous (IV), intramuscular (IM), intranasal (IN), or bone Various drug delivery modalities depending on the clinical situation, including but not limited to intravenous (IO) routes Tea can be tolerated.

[0091] It will be understood that many variations are possible within the scope of the invention described herein. A catch as described herein may also be referred to as a tooth. Many of the details are described by way of example only and should be determined by reference to the claims that follow. It should be understood by those skilled in the art that this is not intended to limit the scope of the present invention. .

Claims

[Claim 1] an applicator including a cartridge receiving receptacle; A replaceable cartridge configured to receive or contain a drug therein. and at least one urinary tractor having a body having a closed position that blocks access to the drug. a barrier member configured to prevent the cartridge from being moved from the closed position to the When inserted into a cartridge receiving receptacle, the drug is applied via the applicator. and the barrier member moves to an open position allowing access to the cartridge. a replaceable receiving receptacle that moves back to said closed position when removed from said receiving receptacle; and a drug syringe comprising:

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