Capacitive sensor array chip and sampling apparatus that adjust pixel resolution in programmable manner, as well as control system therefor
The capacitive sensor array chip with programmable pixel resolution dynamically adjusts electrode sizes to improve spatial resolution and sensitivity, addressing the size mismatch issue and enabling effective single cell detection for biological applications.
Patent Information
- Application Number
- JP2024081458
- Authority / Receiving Office
- JP · JP
- Patent Type
- Applications
- Current Assignee / Owner
- Filing Date
- 2024-05-20
- Publication Date
- 2025-12-03
- Estimated Expiration
- 2044-05-20
AI Technical Summary
Existing capacitive sensor arrays face challenges in achieving balanced spatial resolution and sensitivity due to the size mismatch between electrodes and single cells, limiting the ability to detect single cell behavior effectively.
A capacitive sensor array chip with programmable pixel resolution adjustment, incorporating a programmable module, delay pulse module, and electrode array modules, which dynamically adjusts electrode sizes based on sample characteristics using a time-sharing time-to-digital converter and noise reduction methods.
The solution enhances sensing performance by optimizing spatial resolution and sensitivity, enabling real-time monitoring of single cells with improved digital image processing and noise reduction, suitable for biological applications and personalized medicine.
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Figure 2025175386000001_ABST
Abstract
Description
[Technical Field]
[0001] The present invention relates to a capacitive sensor array chip, and more particularly to a capacitive sensor array chip with programmable pixel resolution adjustment. [Background technology]
[0002] CMOS laboratory chips offer unprecedented applications in life sciences, such as rapid medical testing using digital microfluidics, cell sorting using traveling wave dielectrophoresis, and polymerase chain reaction using heated microelectrode arrays (H-MEAs), which offer lower cost, faster operation, smaller reagent volumes, and higher throughput than traditional methods. Capacitive sensor arrays (CSAs) play a crucial role in collecting the electrical and physical responses of biological targets and providing the correct operation strategies.
[0003] However, due to the size mismatch between a single electrode and a single cell, it is difficult to detect the behavior of a single cell. While real-time monitoring of cell growth by converting capacitance into frequency using a ring oscillator (RO) is sufficient to identify the adhesion of cell clusters, the spatial resolution for observing the behavior of a single cell still needs improvement.
[0004] Therefore, there is an urgent need for a sensing method that can balance spatial resolution and sensitivity by dynamically using corresponding electrode sizes according to sample size. Summary of the Invention [Problem to be solved by the invention]
[0005] SUMMARY OF THE INVENTION It is an object of the present invention to provide a capacitive sensor array chip, sampling device and control system that programmably adjusts pixel resolution to overcome the various problems of the prior art discussed above. [Means for solving the problem]
[0006] To achieve the above object, a first aspect of the present invention provides a capacitive sensor array chip for programmably adjusting pixel resolution, comprising a programmable module, a delay pulse module, and a plurality of electrode array modules.
[0007] The programmable module is used to generate a selection signal based on a first clock signal. The delay pulse module is used to generate a third clock signal based on a second clock signal and a sensing pulse signal. The plurality of electrode array modules include a charging unit for generating a charging signal based on the sensing pulse signal, M×N electrode pixel units (M is a positive integer greater than or equal to 1, and N is a positive integer greater than or equal to 1) forming an array, and a sampling unit for generating a sensing output signal based on the sampling signal and the third clock signal. The electrode array module is used to sequentially select the electrode pixel units of a specific pattern based on the selection signal, and the electrode pixel units of the specific pattern in the electrode array module are used to generate a sampling signal based on the charging signal.
[0008] In one embodiment of the present invention, the electrode pixel unit includes an electrode, a first transistor having a drain connected to the electrode, and a switching logic gate having an input terminal receiving the selection signal and an output terminal connected to the gate of the first transistor.
[0009] In one embodiment of the present invention, the selection signal includes an M-bit row signal and an N-bit column signal.
[0010] In one embodiment of the present invention, the charging unit includes a first voltage source, at least one first PMOS connected to the first voltage source, and a first CMOS inverter connected to the at least one first PMOS, wherein an input terminal of the first CMOS inverter receives the sensing pulse signal and an output terminal of the first CMOS inverter outputs the charging signal.
[0011] In one embodiment of the present invention, the charging unit includes a second voltage source, a second CMOS inverter connected to the second voltage source, at least one second PMOS connected to the second CMOS inverter, and a third multiplexer connected to the at least one second PMOS, a first input terminal of the third multiplexer is connected to a control voltage, and when the third multiplexer selects the first input terminal, the third multiplexer controls the output current of the at least one second PMOS through the control voltage, an input terminal of the second CMOS inverter receives the sensing pulse signal, and an output terminal of the second CMOS inverter outputs the charging signal.
[0012] In one embodiment of the present invention, the delay pulse module includes a first DFF, a delay time generator (DPDG) connected to the output terminal of the first DFF, and a first multiplexer, wherein a clock input terminal of the first DFF receives the sensing pulse signal, a first input terminal of the first multiplexer is connected to the output terminal of the delay time generator, a second input terminal of the first multiplexer receives a second clock signal, and an output terminal of the first multiplexer outputs the third clock signal.
[0013] In one embodiment of the present invention, the sampling unit includes a first INV, a second multiplexer, and a second DFF. The input terminal of the first INV receives the sampling signal, the first input terminal of the second multiplexer is connected to the output terminal of the first INV. The clock input terminal of the second DFF receives the third clock signal, the input terminal of the second DFF is connected to the output terminal of the second multiplexer, and the output terminal of the second DFF outputs the sensing output signal and is connected to the second input terminal of the second multiplexer of the sampling unit of the next electrode array module to form a serial output.
[0014] In one embodiment of the present invention, the first INV is a Hi-Skew inverter.
[0015] In one embodiment of the present invention, the electrodes of the electrode pixel units are arranged in a square, staggered or aligned pattern, and the electrode pixel units may or may not include a guard ring.
[0016] In one embodiment of the present invention, the electrode pixel unit is made of the top layer metal material or the next layer metal material.
[0017] A second aspect of the present invention provides a sampling device, comprising: The present invention comprises a capacitive sensor array chip for programmably adjusting pixel resolution according to the first aspect of the present invention, a protective layer covering the capacitive sensor array chip for programmably adjusting pixel resolution, a container for accommodating the capacitive sensor array chip for programmably adjusting pixel resolution, and an insulator arranged to surround the capacitive sensor array chip for programmably adjusting pixel resolution and for firmly connecting the container and the capacitive sensor array chip for programmably adjusting pixel resolution.
[0018] A third aspect of the present invention provides a control system for controlling a capacitance sensor array chip with programmable pixel resolution to sense a sample, the control system comprising: the capacitance sensor array chip with programmable pixel resolution according to the first aspect of the present invention; and a control unit for determining resistance and capacitance values during sampling and controlling the electrode pixel units.
[0019] In one embodiment of the invention, the control unit comprises shift registers for determining resistance and capacitance values at sample times to establish equivalent electrode sizes.
[0020] In one embodiment of the present invention, the shift register is an (M+N)-bit shift register.
[0021] In one embodiment of the present invention, the control system further comprises a programmable board connected to the capacitive sensor array chip for programmably adjusting pixel resolution and the control unit for arranging signals of the control unit and transmitting information generated by the capacitive sensor array chip for programmably adjusting pixel resolution to an external processor.
[0022] In one embodiment of the invention, the control system further comprises an optical imaging device for recording the sample to generate the optical pattern.
[0023] In one embodiment of the invention, the optical pattern is used to verify the correlation of the capacitance pattern obtained after the control system has taken the sample.
[0024] In one embodiment of the present invention, the control system is used to capture a first noise, which is a fixed pattern noise on a capacitive sensor array chip to programmably adjust the pixel resolution.
[0025] In one embodiment of the invention, the control system is adapted to take the samples sequentially to obtain multiple frames.
[0026] In one embodiment of the present invention, the programmable board is used to average the multiple frames to remove second noise and obtain the appearance characteristics of the sample, where the second noise is random noise.
[0027] In one embodiment of the present invention, the programmable board further removes the first noise in the appearance features of the sample to obtain a pure sample value of the sample. [Effects of the Invention]
[0028] The capacitance sensor array chip, sampling device and control system with programmable pixel resolution provided by the present invention combine an interface, readout circuit and sampling circuit within the pixel, and can dynamically adjust the electrode size according to the characteristics of the biological sample being tested, not only improving the sensing performance but also optimizing the sampling sensitivity through a predetermined fusion pixel mode. [Brief explanation of the drawings]
[0029] [Figure 1] 1 is a functional block diagram of a capacitive sensor array chip with programmable pixel resolution adjustment according to a first embodiment of the present invention; [Figure 2] FIG. 10 is a schematic circuit diagram of an electrode array module according to a second embodiment of the present invention. [Figure 3] FIG. 10 is a schematic circuit diagram of a delay pulse module according to a third embodiment of the present invention. [Figure 4] 10 is a timing chart according to a fourth embodiment of the present invention. [Figure 5] FIG. 10 is a schematic circuit diagram of a charging unit according to a fifth embodiment of the present invention. [Figure 6(a)] 10A and 10B are a schematic view and a schematic cross-sectional view of a sampling device according to a sixth embodiment of the present invention. [Figure 6(b)] 10A and 10B are a schematic view and a schematic cross-sectional view of a sampling device according to a sixth embodiment of the present invention. [Figure 7] FIG. 10 is a schematic diagram of a control system according to a seventh embodiment of the present invention. [Figure 8] FIG. 13 shows capacitance values measured by taking different samples in different fused pixel modes using a control system according to an eighth embodiment of the present invention. [Figure 9] FIG. 13 is a diagram showing the results of real-time monitoring of a sample using a control system according to a ninth embodiment of the present invention. DETAILED DESCRIPTION OF THE INVENTION
[0030] The implementation of the present invention will be described below through specific embodiments, and those skilled in the art will readily understand other advantages and effects of the present invention from the contents disclosed herein. The present invention may also be implemented or applied through other different specific embodiments, and various details of the present specification may be variously refined and modified based on different viewpoints and applications without departing from the spirit of the present invention.
[0031] [First embodiment] Referring to Figure 1, Figure 1 is a functional block diagram of a capacitive sensor array chip with programmable pixel resolution adjustment according to a first embodiment of the present invention. As shown in the figure, the capacitive sensor array chip with programmable pixel resolution adjustment of the present invention includes a programmable module 10, a delay pulse module 11, and electrode array modules 12a and 12b. In the embodiment of Figure 1, two electrode array modules 12a and 12b are used as an example, but this is not limiting and more electrode array modules may be used in other embodiments.
[0032] The programmable module 10 is used to generate a selection signal based on a first clock signal. The delay pulse module 11 is used to generate a third clock signal based on a second clock signal and a sensing pulse signal. The electrode array module 12a includes a charging unit 120a, a plurality of electrode pixel units 121a, and a sampling unit 122a. The electrode array module 12b similarly includes a charging unit 120b, a plurality of electrode pixel units 121b, and a sampling unit 122b.
[0033] The charging units 120a and 120b are used to generate charging signals according to the sensing pulse signals, for example, when an object contacts the electrode pixel unit 121a, the capacitance value of the electrode pixel unit 121a changes, and the charging unit 120a is further used to convert the change in capacitance value into a difference in charging time.
[0034] The plurality of electrode pixel units 121a form an M×N array, where M is a positive integer greater than or equal to 1 and N is a positive integer greater than or equal to 1. The plurality of electrode pixel units 121b similarly form an M×N array. The electrode array module 12a is used to sequentially select the electrode pixel units 121a of a specific pattern based on the selection signal, and the electrode pixel units 121a of the specific pattern in the electrode array module 12a are used to generate a sampling signal based on the charging signal. The sampling unit 122a is used to generate the sampling signal and the third clock signal to generate a sensing output signal. The operation mode of the electrode array module 12b is the same as that of the electrode array module 12a. More specifically, the delay pulse module 11 generates the third clock signal and determines whether the sampling unit 122a of the electrode array module 12a or the sampling unit 122b of the electrode array module 12b generates a sensing output signal based on the third clock signal.
[0035] The programmable module 10 is used to generate the selection signal, and the electrode array module 12a is used to sequentially select the electrode pixel units 121a of a specific pattern based on the selection signal. For example, the specific pattern may be, but is not limited to, 1x1, 1x2, 2x2, 2x4, or 4x4. The appropriate specific pattern is selected according to the size of the test sample.
[0036] Prior art sampling circuits for capacitive sensor arrays, such as ADCs, generally require large areas and complex systems to achieve high accuracy. Therefore, prior art sampling circuits are difficult to embed into the pixels of a sensor array, limiting the sensing output. Compared to the prior art, the capacitive sensor array chip with programmable pixel resolution of the present invention integrates a charging unit 120a, multiple electrode pixel units 121a, and a sampling unit 122a into an electrode array module 12a, and realizes a time-sharing time-to-digital converter (ts-TDC) through the control of the programmable module 10 and the delay pulse module 11. This method allows the capacitive sensor array chip to operate in global shutter mode, freeing up more area under the electrodes and enabling future multi-module integration. The programmable electrode configuration of this design improves sensing performance by capturing multiple frames of the same or different patterns for improved digital image processing.
[0037] [Second embodiment] 2, which is a schematic circuit diagram of an electrode array module according to a second embodiment of the present invention. In one embodiment, the electrode array module 20 includes a charging unit 200, electrode pixel units 201a, 201b, 201c, and 201d, and a sampling unit 202. The electrode pixel unit 201a includes an electrode 2010a, a first transistor 2011a whose drain is connected to the electrode 2010a, and a switching logic gate 2012a. The input terminal of the switching logic gate 2012a receives a charging signal, and the output terminal of the switching logic gate 2012a is connected to the gate of the first transistor 2011a. Similarly, the electrode pixel units 201b, 201c, and 201d respectively include electrodes 2010b, 2010c, and 2010d, first transistors 2011b, 2011c, and 2011d, and switching logic gates 2012b, 2012c, and 2012d.
[0038] In one embodiment, the first transistors 2012a, 2012b, 2012c, and 2012d may be, but are not limited to, NMOS or PMOS transistors, and the switching logic gates 2011a, 2011b, 2011c, and 2011d may be implemented with logic gates such as NOR, NAND, or a single NMOS, but are not limited to these.
[0039] In the embodiment of FIG. 2, the 2×2 electrode pixel units 201a, 201b, 201c, and 201d are taken as an example, but are not limited thereto.
[0040] In one embodiment, the selection signals include M-bit row signals R[0] to R[M-1] and N-bit column signals C[0] to C[N-1].
[0041] In one embodiment, the charging unit 200 includes a first voltage source 2000, first PMOS transistors 2001a, 2001b, and 2001c connected to the first voltage source 2000, and a first CMOS inverter 2002 connected to the first PMOS transistor 2001c. The input terminal of the first CMOS inverter 2002 receives a sensing pulse signal SP, and the output terminal of the first CMOS inverter 2002 outputs a charging signal. In the embodiment of FIG. 2, three first PMOS transistors 2001a, 2001b, and 2001c are used as an example, but are not limited thereto. In other embodiments, more or fewer first PMOS transistors can be used to adjust the current.
[0042] In one embodiment, the sampling unit 202 includes a first INV 2020, a second multiplexer 2021, and a second DFF 2022. The input terminal of the first INV 2020 receives the sampling signal, and the first input terminal of the second multiplexer 2021 is connected to the output terminal of the first INV 2020. The clock input terminal of the second DFF 2022 receives the third clock signal DFF_CLK, and the input terminal of the second DFF 2022 is connected to the output terminal of the second multiplexer 2021. The output terminal of the second DFF 2022 outputs the sensing output signal, which is connected to the second input terminal of the second multiplexer of the sampling unit of the next electrode array module to form a serial output. In other words, signal Qn is sent to the next electrode array module, and signal Qn-1 is from the previous electrode array module.
[0043] In one embodiment, the first INV 2020 is a Hi-Skew inverter to improve the sensing effect.
[0044] [Third embodiment] 3, which is a schematic circuit diagram of a delay pulse module according to a third embodiment of the present invention. In one embodiment, the delay pulse module 30 includes a first DFF 300, a delay time generator 301 connected to the output terminal of the first DFF 300, and a first multiplexer 302. The clock input terminal of the first DFF 300 receives the sensing pulse signal SP, the first input terminal of the first multiplexer 302 is connected to the output terminal of the delay time generator 301, the second input terminal of the first multiplexer 302 receives the second clock signal scan_out_clk, and the output terminal of the first multiplexer 302 outputs the third clock signal DFF_CLK.
[0045] [Fourth embodiment] Referring to FIG. 4, FIG. 4 is a timing chart of a fourth embodiment of the present invention. As shown, the circuit includes a sensing pulse signal SP and a voltage signal Electrode(N0) of the electrode pixel unit. Din(N1) is the input signal of the second DFF. The third clock signal DFF_CLK is the signal at the clock input terminal of the second DFF. The sensing output signal DFF_Qn is the signal at the output terminal of the second DFF. First, a charging unit is used to convert capacitance to time. When the sensing pulse signal SP is at a low potential, the first voltage source begins to charge the electrode pixel unit M. The output of the first INV is turned off until the voltage signal Electrode(N0) of the electrode pixel unit reaches 0.8VDD. Next, the second DFF performs sampling N with a delay code. FIG. 4 shows the situations of no sample (Cpar) and sample (Csample), where signals Qpar and Qsample are both logic 1. These processes are repeated multiple times, with a slight delay in the sampling time of the second DFF. In the case of signal Qpar after t1, since it has already reached 0.8VDD, signal Qpar becomes logic 0, but signal Qsample remains logic 1. In the case of signal Qsample after t2, it is finally lowered to logic 0. Finally, all the Q values are added together to obtain the exact time difference between these two situations. The corresponding capacitance result can be estimated. The design scheme of the present invention allows the sampling circuit to be embedded in the pixel, and the purpose can be achieved by using only a simple delay time generator.
[0046] [Fifth embodiment] 5, which is a schematic circuit diagram of a charging unit according to a fifth embodiment of the present invention. In one embodiment, the charging unit 500 includes a second voltage source 5000, a second CMOS inverter 5001 connected to the second voltage source 5000, second PMOS transistors 5002a, 5002b, and 5002c connected to the second CMOS inverter 5001, and a third multiplexer 5003 connected to the second PMOS transistor 5002b. The first input terminal of the third multiplexer 5003 is connected to a control voltage Vctrl. When the third multiplexer 5003 selects the first input terminal, the control voltage Vctrl can be changed to control the magnitude of the output current of the second PMOS transistors 5002a, 5002b, and 5002c, thereby adjusting the sensing amplification factor (sensitivity). The input terminal of the second CMOS inverter 5001 receives a sensing pulse signal SP, and the output terminal of the second CMOS inverter 5001 outputs a charging signal. 5, three second PMOSs 5002a, 5002b, and 5002c are used as an example, but are not limited to this. In other embodiments, more or fewer second PMOSs can be used to adjust the current.
[0047] In one embodiment of the present invention, the electrodes of the electrode pixel units are arranged in a square, staggered or aligned pattern, and the electrode pixel units may or may not include a guard ring.
[0048] In one embodiment, the electrode pixel unit is made of the top layer metal material or the next layer metal material.
[0049] [Sixth embodiment] 6(a) and 6(b) are a schematic diagram and a schematic cross-sectional view of a sampling device according to a sixth embodiment of the present invention. In one embodiment, the sampling device of the present invention includes a capacitive sensor array chip 60 having a programmable pixel resolution according to the first aspect of the present invention, a protective layer 61 covering the capacitive sensor array chip 60 having a programmable pixel resolution, a container 62 for accommodating the capacitive sensor array chip 60 having a programmable pixel resolution, and an insulator 63 provided to surround the capacitive sensor array chip 60 having a programmable pixel resolution and for firmly connecting the container 62 and the capacitive sensor array chip 60 having a programmable pixel resolution.
[0050] In one embodiment, the programmable pixel resolution capacitance sensor array chip 60 can be secured to a printed circuit board 64 with an insulator 63, such as, but not limited to, a high resistance, non-conductive medical grade epoxy, to effectively shield the metal lines of the chip.
[0051] In one embodiment, the capacitance sensor array chip 60 with programmable pixel resolution adjustment includes a sensing area 601, preferably, the upper part of the sensing area 601 can contact the biological sample to be tested.
[0052] In one embodiment, the capacitive sensor array chip 60 with programmable pixel resolution adjustment is provided with bonding wires 602 that can be secured and protected with another insulating material to prevent interaction with liquids or solutions. In one embodiment, the capacitive sensor array chip 60 with programmable pixel resolution is bonded on only one side to ensure sufficient space is available for other operations.
[0053] In accordance with the present invention, a layer of medical-grade epoxy 63 can be applied and cured around the periphery of the programmably adjustable pixel resolution capacitance sensor array chip 60. A laser-cut container, such as a Petri dish 62, is then attached to a printed circuit board 64, and the medical epoxy is re-cured. The Petri dish can then contain culture media and cells and be used for cell growth and interaction.
[0054] [Seventh embodiment] 7 is a schematic diagram of a control system according to a seventh embodiment of the present invention. Referring to both FIGS. 1 and 7, the control system of the present invention is used to control the capacitance sensor array chip that programmably adjusts pixel resolution to sense a sample, and includes a capacitance sensor array chip 70 that programmably adjusts pixel resolution, and a control unit 71 that determines resistance and capacitance values during sampling and controls the electrode pixel units 121a.
[0055] In one embodiment, the control unit 71 includes a shift register 711 for determining resistance and capacitance values at the time of sampling to establish equivalent electrode sizes.
[0056] In one embodiment, the shift register 711 may be an (M+N) bit shift register.
[0057] Referring back to FIG. 3, in one embodiment, the control unit 71 may be used to generate and send a pulse to the delay time generator 301 after sensing the pulse signal SP.
[0058] In one embodiment, the control system further comprises a programmable board 72 connected to the capacitive sensor array chip 70 for programmably adjusting pixel resolution and the control unit 71 for arranging signals of the control unit 71 and transmitting information generated by the capacitive sensor array chip 70 for programmably adjusting pixel resolution to an external processor 74.
[0059] In one embodiment, the programmable board 72 may be, for example, but not limited to, a Field Programmable Gate Array (FPGA) board.
[0060] In one embodiment, the control system further comprises an optical imaging device 73 for recording the sample to generate an optical pattern. According to the present invention, the optical imaging device 73 may be, for example but not limited to, a microscope. In one embodiment, the optical pattern can be used to verify the correlation of a capacitance pattern obtained after the control system has sampled the sample.
[0061] Specifically, the control system provided by the present invention can be used to capture first noise, which is fixed pattern noise on a capacitive sensor array chip to programmably adjust the pixel resolution.
[0062] In one embodiment, the control system can be used to continuously acquire the sample to obtain multiple frames. In a preferred embodiment, the programmable board is used to average the multiple frames to remove second noise and obtain the appearance characteristics of the sample, where the second noise is random noise.
[0063] In a preferred embodiment, the programmable board can further remove the first noise in the appearance characteristics of the sample to obtain a pure sample value of the sample.
[0064] [Eighth embodiment] Referring to FIG. 8, FIG. 8 is a diagram showing capacitance values measured by taking different samples in different fused pixel modes using a control system according to an eighth embodiment of the present invention.
[0065] FIG. 8 shows the control system provided by the present invention sampling each electrode unit with dynamically adjusted pixel patterns of 1×1, 1×2, 2×2, 2×4, and 4×4, respectively, and the results are shown in Table 1. TM The samples shown include four types of samples: stem cell culture medium (CM), saturated saline (SALT), and deionized water (DIW). The obtained capacitance reflects the magnitude of the relative dielectric constant. The values are SALT, CM, DIW, and OIL in descending order, which is consistent with the results of the prior art.
[0066] [Ninth embodiment] Referring to Figure 9, this figure shows the results of real-time sample monitoring using a control system according to a ninth embodiment of the present invention. The real-time monitoring times were t = 5, 15, 25, 27, 29, and 110 minutes. Saturated saline was used as the target sample. At room temperature, 10 μL of saturated saline was dropped onto the surface of a capacitance sensor array chip with programmable pixel resolution provided by the present invention, and the liquid and solid detection results were observed. In this embodiment, 4x4 pixel fusion was enabled. As can be seen from Figure 9, the droplet gradually became smaller before t = 27 minutes. After that, several flake-like salt crystals appeared, but because they were not in direct contact with the chip surface, they only reflected their shape. This indicates that the longer the distance between the sample and the chip, the smaller the change in capacitance due to the electrodes.
[0067] The present invention provides a capacitive sensor array chip with programmable pixel resolution adjustment, a sampling device, and a control system that can effectively adjust the electrode size to adapt to the size of a biological sample, thereby achieving better sensing results and simultaneously balancing spatial resolution and sensitivity. The present invention uses a time-to-digital conversion circuit method and a noise reduction method to achieve a higher pixel count in global shutter mode, and the sampling results are consistent with the configuration of an optical imaging device. The present invention integrates multiple functions and contributes to the development of a large number of biological applications and personalized medicine. [Explanation of symbols]
[0068] 10 programmable module, 11 delay pulse module, 12a, 12b electrode array module, 120a, 120b charging unit, 121a, 121b electrode pixel unit, 122a, 122b sampling unit, 20 electrode array module, 200 charging unit, 201a, 201b, 201c, 201d electrode pixel unit, 202 sampling unit, 2010a, 2010b, 2010c, 2010d electrode, 2011a, 2011b, 2011c, 2011d first transistor, 2012a, 2012b, 2012c, 2012d switching logic gate, 2000 first voltage source, 2001a, 2001b, 2001c first PMOS, 2002 first CMOS inverter, 2020 first INV 2020, 2021 Second multiplexer, 2022 Second DFF, 30 Delay pulse module, 300 First DFF, 301 Delay time generator, 302 First multiplexer, 500 Charging unit, 5000 Second voltage source, 5001 Second CMOS inverter 5001, 5002a, 5002b, 5002c Second PMOS, 5002a, 5002b, 5002c, 5003 Third multiplexer, 60 Capacitive sensor array chip for programmably adjusting pixel resolution, 61 Protective layer, 62 Container, 63 Insulator, 64 Printed circuit board, 601 Sensing area, 602 Bonding wire, 70 Capacitive sensor array chip for programmably adjusting pixel resolution, 71 Control unit, 711 Shift register, 72 Programmable substrate, 73 Optical imaging device, 74 External processor.
Claims
1. a programmable module for generating a selection signal based on a first clock signal; a delay pulse module for generating a third clock signal based on the second clock signal and the sensing pulse signal; a charging unit for generating a charging signal based on the sensing pulse signal; M×N electrode pixel units (M is a positive integer of 1 or more, and N is a positive integer of 1 or more) forming an array; a sampling unit for generating a sensing output signal based on a sampling signal and the third clock signal; a plurality of electrode array modules used to sequentially select the electrode pixel units of a specific pattern according to the selection signal, and the electrode pixel units of the specific pattern are used to generate the sampling signal according to the charging signal; 1. A capacitive sensor array chip for programmably adjusting pixel resolution, comprising:
2. The electrode pixel unit comprises: An electrode; a first transistor having a drain connected to the electrode; a switching logic gate having an input terminal for receiving the selection signal and an output terminal connected to the gate of the first transistor; The capacitive sensor array chip with programmable pixel resolution adjustment according to claim 1 , comprising:
3. 2. The capacitive sensor array chip for programmably adjusting pixel resolution according to claim 1, wherein the selection signal includes an M-bit row signal and an N-bit column signal.
4. The charging unit is a first voltage source; At least one first PMOS connected to the first voltage source; a first CMOS inverter connected to the at least one first PMOS; 2. The capacitive sensor array chip as claimed in claim 1, wherein an input terminal of the first CMOS inverter receives the sensing pulse signal, and an output terminal of the first CMOS inverter outputs the charging signal.
5. The charging unit is a second voltage source; a second CMOS inverter connected to the second voltage source; at least one second PMOS connected to the second CMOS inverter; a third multiplexer connected to the at least one second PMOS, the first input terminal of which is connected to a control voltage, and which controls an output current of the at least one second PMOS through the control voltage when the third multiplexer selects the first input terminal; 2. The capacitive sensor array chip as claimed in claim 1, wherein an input terminal of the second CMOS inverter receives the sensing pulse signal, and an output terminal of the second CMOS inverter outputs the charging signal.
6. The delay pulse module includes: a first DFF having a clock input terminal for receiving the sensing pulse signal; a delay time generator (DPDG) connected to the output terminal of the first DFF; a first multiplexer; 2. The capacitive sensor array chip with programmable pixel resolution adjustment as claimed in claim 1, wherein a first input terminal of the first multiplexer is connected to an output terminal of the delay time generator, a second input terminal of the first multiplexer receives a second clock signal, and an output terminal of the first multiplexer outputs the third clock signal.
7. The sampling unit comprises: a first INV having an input terminal for receiving the sampling signal; a second multiplexer having a first input connected to the output of the first INV; a second DFF; 2. The capacitive sensor array chip with programmable pixel resolution adjustment as claimed in claim 1, wherein a clock input terminal of the second DFF receives the third clock signal, an input terminal of the second DFF is connected to an output terminal of the second multiplexer, and an output terminal of the second DFF outputs the sensing output signal and is connected to a second input terminal of the second multiplexer of a sampling unit of a next electrode array module to form a serial output.
8. 8. The capacitive sensor array chip for programmably adjusting pixel resolution according to claim 7, wherein the first INV is a Hi-Skew inverter.
9. 3. The capacitive sensor array chip with programmable pixel resolution adjustment as claimed in claim 2, wherein the electrodes of the electrode pixel units are arranged in a square, staggered or aligned pattern, and the electrode pixel units include or do not include a guard ring.
10. The capacitive sensor array chip with programmable pixel resolution adjustment as claimed in claim 9 , wherein the electrode pixel unit is made of the metal material of the top layer or the metal material of the next layer.
11. A capacitive sensor array chip with programmable pixel resolution adjustment according to any one of claims 1 to 9; a protective layer covering the capacitive sensor array chip for programmably adjusting pixel resolution; a container for containing the capacitive sensor array chip for programmably adjusting pixel resolution; an insulator provided to surround the periphery of the capacitive sensor array chip for programmably adjusting pixel resolution, for fastening the container and the capacitive sensor array chip for programmably adjusting pixel resolution; A sampling device comprising:
12. a capacitance sensor array chip that programmably adjusts pixel resolution and is used to sense the sample; A capacitive sensor array chip with programmable pixel resolution adjustment according to any one of claims 1 to 10; a control unit for determining a resistance value and a capacitance value at the time of sampling and controlling the electrode pixel unit; A control system comprising:
13. 13. The control system of claim 12, wherein the control unit comprises a shift register for determining resistance and capacitance values at sample times to establish equivalent electrode sizes.
14. 14. The control system of claim 13, wherein the shift register is an (M+N) bit shift register.
15. 13. The control system of claim 12, further comprising a programmable board connected to the capacitive sensor array chip that programmably adjusts pixel resolution and the control unit, for arranging signals of the control unit and transmitting information generated by the capacitive sensor array chip that programmably adjusts pixel resolution to an external processor.
16. 13. The control system of claim 12, further comprising an optical imaging device for recording the sample to generate an optical pattern.
17. 17. The control system of claim 16, wherein the optical pattern is used to verify the correlation of a capacitance pattern obtained after the control system has taken the sample.
18. 16. The control system of claim 15, adapted to capture a first noise that is a fixed pattern noise on a capacitive sensor array chip that programmably adjusts the pixel resolution.
19. 20. The control system of claim 18, adapted to take the samples sequentially to obtain multiple frames.
20. 20. The control system of claim 19, wherein the programmable board is used to average the plurality of frames to remove second noise and obtain the appearance characteristics of the specimen, the second noise being random noise.
21. 20. The control system of claim 19, wherein the programmable board further removes the first noise in the appearance characteristics of the specimen to obtain a pure specimen value of the specimen.
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