Liquid injection device and drug dissolution kit

Abstract

To provide a liquid injection device and a drug dissolution kit capable of smoothly injecting a liquid filled in a prefilled syringe into a container accommodating a drug.SOLUTION: A liquid injection device comprises a syringe mounting member 110 to which a first prefilled syringe 210 and a second prefilled syringe 220 are mountable, and an assist mechanism 120 provided on the syringe mounting member and configured to assist movement of a first plunger 211 included in the first prefilled syringe toward a distal end side, wherein the assist mechanism includes a pressing portion 130 that applies a pressing force toward the distal end side to a proximal end 213 of the first plunger, a pressing drive portion 160 that generates the pressing force, and a switching portion 170 that enables switching from a standby state before generation of the pressing force to a driven state in which the pressing force is generated.SELECTED DRAWING: Figure 2

Description

[Technical Field]

[0001] The present invention relates to a liquid injection device and a drug dissolution kit. [Background technology]

[0002] In medical settings, a predetermined amount of liquid such as dissolving water is sometimes injected into a container (vial) containing a drug or other substance to be used inside a patient's body, and the drug and liquid are mixed and stirred in the container to dissolve or dilute the drug. For example, as described in Patent Document 1, when using a coating material or the like composed of two or more drugs to be used inside a living body, two or more containers containing different drugs are prepared. [Prior art documents] [Patent documents]

[0003] [Patent Document 1] Japanese Patent Publication No. 2020-156924 Summary of the Invention [Problem to be solved by the invention]

[0004] When injecting liquid into each of a plurality of containers, a prefilled syringe containing the liquid may be used. Furthermore, when injecting liquid using a prefilled syringe, the inside of the container containing the drug may be kept under negative pressure. Because the inside of the container is under negative pressure, when the prefilled syringe and the container are connected, the plunger of the prefilled syringe can be automatically moved (advance) using the negative pressure, and the injection of liquid from the prefilled syringe into the container can be started.

[0005] However, when a prefilled syringe is used to inject a liquid into a container, the injection pressure of the liquid depends on the movement of the plunger of the prefilled syringe. For example, if the sliding resistance of the gasket of the plunger is greater than the ideal setting, the movement speed of the plunger may be slower than expected, which may hinder smooth injection of the liquid into the container. As a result, it may take longer to dissolve the drug contained in the container.

[0006] The present invention has been made in consideration of the above-mentioned problems, and aims to provide a liquid injection device and a drug dissolution kit that can smoothly inject a liquid filled in a prefilled syringe into a container containing a drug, and that makes it possible to dissolve the drug contained in the container in a short period of time. [Means for solving the problem]

[0007] The present invention can be achieved by any one of the following means (1) to (7).

[0008] (1) a syringe mounting device capable of mounting a first prefilled syringe and a second prefilled syringe, each prefilled with a predetermined liquid to be injected into a first container and a second container, each of which contains a predetermined drug and is maintained at a negative pressure; an assist mechanism provided in the syringe mounting fixture and assisting the movement of a first plunger of the first prefilled syringe toward the tip side and / or the movement of a second plunger of the second prefilled syringe toward the tip side, The assist mechanism includes: a pressing unit that applies a pressing force toward a distal end side to the base end of the first pusher and / or the base end of the second pusher; a pressure drive unit that generates the pressure; a switching unit that enables switching from a standby state before the pressing force is generated to a driving state in which the pressing force is generated.

[0009] (2) a first drug contained within the first container has a lower solubility than a second drug contained within the second container; The liquid injection device described in (1), wherein the assist mechanism is configured to assist the movement of the first plunger provided on the first syringe filled with the liquid to be injected into the first container.

[0010] (3) The liquid injection device according to (2), wherein the first cylindrical body filled with the liquid in the first prefilled syringe has a larger diameter than the second cylindrical body filled with the liquid in the second prefilled syringe.

[0011] (4) the pressing drive unit has a spring member that is expandable and contractible in an extension direction of the first pusher and the second pusher, the pressing portion has a holding portion that holds the spring member and to which the biasing force generated by the spring member is applied, the switching portion has a stopper that abuts against at least a part of the pressing portion in the standby state to maintain the spring member in a compressed state in the extension direction, The liquid injection device according to any one of (1) to (3), wherein the switching unit extends the spring member in the extension direction by releasing the stopper from contacting the pressing unit, thereby switching from the standby state to the driving state.

[0012] (5) the stopper is attached to the syringe mounting fixture so as to be movable from an initial position in which the stopper is kept in contact with at least a part of the pressing portion to a release position in which the stopper is released from contact with the pressing portion, The liquid injection device according to (4), wherein the stopper has an abutting portion that abuts against at least a part of the pressing portion when the stopper is located at the initial position, and an insertion portion that is provided adjacent to the abutting portion and through which at least a part of the pressing portion is inserted when the stopper moves to the release position, thereby enabling the spring member to extend as the pressing portion moves toward the tip side.

[0013] (6) the stopper has an operation portion that is disposed outside the syringe mounting tool when the stopper is located at the initial position, The liquid injection device according to (5), further comprising a maintaining mechanism that maintains the stopper at the initial position when no external force is applied to the operating portion.

[0014] (7) The liquid injection device according to any one of (1) to (6), a container mounting tool to which the first container and the second container are mounted and which is configured to be connectable to the liquid injection tool, A drug dissolution kit, wherein the container attachment device has a first double-ended needle that, when connected to the liquid injection device, fluidly connects the inside of the first prefilled syringe with the inside of the first container, and a second double-ended needle that fluidly connects the inside of the second prefilled syringe with the inside of the second container. [Effects of the Invention]

[0015] According to the liquid injection device and drug dissolution kit of the present invention, by operating the switching unit of the assist mechanism to apply a pressing force from the pressing unit to the first plunger of the first prefilled syringe and / or the second plunger of the second prefilled syringe, the first plunger and / or the second plunger can be smoothly advanced. This allows the liquid to be smoothly injected into each of the first container and the second container, and makes it possible to dissolve the drug contained in each container in a short time. [Brief explanation of the drawings]

[0016] [Figure 1] FIG. 1 is a diagram showing a drug dissolution kit according to an embodiment. [Figure 2] 1 is an exploded perspective view of a liquid injector device according to an embodiment. FIG. [Figure 3] 1A and 1B are diagrams for explaining an example of use of the liquid injector device according to the embodiment. [Figure 4] 1A and 1B are diagrams for explaining an example of use of the liquid injector device according to the embodiment. [Figure 5] 1A and 1B are diagrams for explaining an example of use of the liquid injector device according to the embodiment. DETAILED DESCRIPTION OF THE INVENTION

[0017] Hereinafter, embodiments of the present invention will be described with reference to the accompanying drawings. Note that the following description does not limit the technical scope or meaning of terms described in the claims. Also, the dimensional proportions in the drawings are exaggerated for the convenience of explanation and may differ from the actual proportions.

[0018] Fig. 1 is a diagram showing a drug dissolving kit 10 according to this embodiment, and Fig. 2 is a diagram showing an exploded perspective view of a liquid injection instrument 100. Figs. 3 to 5 are diagrams (partial cross-sectional views) showing examples of use of the liquid injection instrument 100.

[0019] <Drug dissolution kit 10> As shown in FIG. 1, the drug dissolving kit 10 includes a liquid injection tool 100 and a container attachment tool 300.

[0020] The liquid injection device 100 is configured to be able to mount two syringes, a first prefilled syringe 210 and a second prefilled syringe 220. The container mounting device 300 is configured to be able to mount two containers, a first container 410 and a second container 420.

[0021] The drug dissolving kit 10 can be used, for example, when using an applicator (sprayer) for administering a coating material such as an adhesion inhibitor or a biological tissue adhesive. When diluting or stirring the drugs M1 and M2 contained in the containers 410 and 420, an operator (for example, a medical professional such as a doctor) connects the liquid injection device 100 to the container attachment device 300 and injects the liquids filled in the syringes 210 and 220 into the containers 410 and 420.

[0022] <Liquid injection equipment 100> 1 to 5, the liquid injection device 100 comprises a syringe mounting fixture 110 to which a first prefilled syringe 210 prefilled with a predetermined liquid L1 to be injected into a first container 410 containing a predetermined drug M1 in an interior 410a maintained at negative pressure, and a second prefilled syringe 220 prefilled with a predetermined liquid L2 to be injected into a second container 420 containing a predetermined drug M2 in an interior 420a maintained at negative pressure can be attached, and an assist mechanism 120 provided on the syringe mounting fixture 110 to assist the movement of a first plunger 211 provided on the first prefilled syringe 210 toward the tip.

[0023] <Syringe attachment 110> As shown in FIG. 2, the syringe mounting fixture 110 has an elongated outer shape extending in the longitudinal direction.

[0024] The interior of the syringe mounting fixture 110 is divided by a partition 111 provided along part of the longitudinal direction of the syringe mounting fixture 110 into a first space 110A in which the first prefilled syringe 210 is placed and a second space 110B in which the second prefilled syringe 220 is placed.

[0025] In each figure, the longitudinal direction of the syringe mounting fixture 110 is indicated by arrow X1-X2, and the width direction perpendicular to the longitudinal direction is indicated by arrow Y1-Y2. In this specification, the side indicated by arrow X1 is referred to as the "tip side," and the side indicated by arrow X2 is referred to as the "base side." The forward movement direction of each plunger 211, 221 provided on each syringe 210, 220 is the direction indicated by arrow X1.

[0026] 1 and 2, the syringes 210, 220 mounted on the syringe mounting fixture 110 are arranged adjacent to each other in the width direction. A portion of the tip side of each syringe 210, 220 is arranged so as to be exposed to the outside of the syringe mounting fixture 110.

[0027] As shown in FIGS. 2 and 3, a pressing portion 130 of the assist mechanism 120 is disposed at the base end of the syringe mounting fixture 110 at a position overlapping with the first prefilled syringe 210 in the longitudinal direction.

[0028] As shown in FIGS. 2 to 5, various structures 113, 115, 116, and 117 for assembling assist mechanism 120 and controlling the operation of assist mechanism 120 are provided near the proximal end of syringe mounting fixture 110.

[0029] A fixing groove 113 for fixing the outer cylinder part 150 of the pressing part 130 is provided on the extension of the base end side of the first space 110A of the syringe mounting fixture 110.

[0030] A slide groove 115 extending in the width direction is provided on an extension of the base end side of second space 110B of syringe mounting fixture 110. Slide groove 115 slidably holds locking protrusion 186 provided on stopper 180 of switching section 170.

[0031] At a position closer to the tip end than the slide groove 115, a hole 116 is provided that allows a part of an operation part 188 provided on the stopper 180 of the switching part 170 to project outside the syringe mounting fixture 110.

[0032] A holding groove 117 for holding the holding mechanism 190 is provided at a location adjacent to the hole 116 in the width direction.

[0033] <Assist mechanism 120> As shown in Figures 3 to 5, the assist mechanism 120 has a pressing unit 130 that applies a pressing force toward the tip side to the base end 213 of the first plunger 211 of the first prefilled syringe 210, a pressing drive unit 160 that generates the pressing force, and a switching unit 170 that enables switching from a standby state before the pressing force is generated to a drive state in which the pressing force is generated.

[0034] FIG. 3 shows the standby state, FIG. 4 shows the state when the switching unit 170 is operated to switch from the standby state to the driving state, and FIG. 5 shows the driving state.

[0035] The pressing drive unit 160 has a spring member 165 that can expand and contract in the extending direction of the first pusher 211. The spring member 165 can be configured, for example, by a known coil spring.

[0036] The pressing portion 130 has a holding portion 140 that holds the spring member 165 and to which the biasing force generated by the spring member 165 is applied.

[0037] As shown in FIGS. 3 to 5, a part of the pressing portion 130 is disposed so as to protrude from the base end of the syringe mounting fixture 110 to the outside of the syringe mounting fixture 110.

[0038] The holding portion 140 provided in the pressing portion 130 is configured as a shaft-shaped member extending in the longitudinal direction. A large diameter portion 141 is provided at the tip side of the holding portion 140, and a small diameter portion 143 is provided at the base end side of the large diameter portion 141.

[0039] At the boundary between the large diameter portion 141 and the small diameter portion 143, a flange portion 146 is provided to which a tip end 165a of a spring member 165 is engaged.

[0040] Near the tip of the holding portion 140, a locking groove 145 is provided for contacting and releasing the contact with the contact portion 181 of the stopper 180.

[0041] The pressing portion 130 has an outer cylinder portion 150 that covers the base end side portion of the holding portion 140. The outer cylinder portion 150 has a fixing protrusion 151 that is engaged with a fixing groove 113 of the syringe mounting fixture 110. The position of the outer cylinder portion 150 is fixed relative to the syringe mounting fixture 110 via the fixing protrusion 151 and the fixing groove 113.

[0042] The base end portion 153 of the outer cylinder portion 150 is provided with a protrusion portion 153 a for holding the base end 165 b of the spring member 165 .

[0043] Protrusion 153a provided on proximal end 153 of outer cylinder 150 is inserted through proximal end 165b of spring member 165, and spring member 165 is fixed to outer cylinder 150. Protrusion 153a is inserted through proximal end 165b of spring member 165, and spring member 165 is arranged to abut against flange 146 of holder 140. In the standby state, spring member 165 is arranged in the space between holder 140 and outer cylinder 150, and maintains a compressed state in the longitudinal direction of syringe mounting fixture 110 (the same direction as the extension direction of spring member 165).

[0044] In the standby state, the switching portion 170 has a stopper 180 that maintains the spring member 165 compressed in the extension direction by abutting against at least a portion of the pressing portion 130 (in this embodiment, the portion where the locking groove 145 of the holding portion 140 is provided).

[0045] By releasing the stopper 180 from contacting the pressing portion 130, the switching portion 170 can extend the spring member 165 in the extension direction, thereby switching from the standby state shown in FIG. 3 to the driving state shown in FIG.

[0046] As shown in Figures 3 to 5, stopper 180 is attached to syringe mounting fixture 110 so as to be movable from an initial position P1 (position shown in Figure 3) where stopper 180 remains in contact with at least a portion of pressing portion 130 to a release position P2 (position shown in Figures 4 and 5) where stopper 180 is released from contact with pressing portion 130.

[0047] As shown in FIG. 3, the stopper 180 has an abutment portion 181 that abuts against at least a part of the pressing portion 130 when the stopper 180 is located at the initial position P1, and an insertion portion 183 that is provided adjacent to the abutment portion 181 and through which at least a part of the pressing portion 130 is inserted when the stopper 180 moves to the release position P2, thereby enabling the spring member 165 to extend as the pressing portion 130 moves toward the tip side.

[0048] As shown in FIG. 3, the stopper 180 has an operating portion 188 that is disposed outside the syringe mounting fixture 110 when the stopper 180 is in the initial position P1.

[0049] The stopper 180 further includes a maintaining mechanism 190 that maintains the stopper 180 at the initial position P1 when no external force is applied to the operating portion 188.

[0050] 3, operation portion 188 of stopper 180 has a shape that extends in the extension direction of syringe mounting fixture 110. Retention mechanism 190 is composed of a spring member that is arranged so that one end portion in the width direction (the end portion located in the direction of arrow Y2) of operation portion 188 abuts against the inner surface that is arranged inside syringe mounting fixture 110. This spring member can be composed of, for example, a known coil spring.

[0051] When the operation section 188 is attached to the syringe mounting fixture 110, the maintenance mechanism 190 is accommodated in a holding groove 117 provided in the syringe mounting fixture 110 in a state compressed in the width direction.

[0052] The stopper 180 has a locking protrusion 186 that is locked into a slide groove 115 formed in the syringe mounting fixture 110. The locking protrusion 186 protrudes along the extension of the syringe mounting fixture 110.

[0053] In the standby state shown in FIG. 3 , stopper 180 is subjected to a widthwise pressing force by an elastic force applied by maintenance mechanism 190. In this state, locking protrusion 186 provided on stopper 180 abuts against an inner wall located on one widthwise end side (arrow Y2 side) of slide groove 115 of syringe mounting fixture 110. As a result, a part of operation portion 188 of stopper 180 is disposed in a state in which at least a part of it protrudes outside syringe mounting fixture 110, as shown in FIG. 3 . Also, in this state, a contact portion 181 located on the other widthwise end side (end located on the arrow Y1 side) of stopper 180 is engaged in a state in which it is caught in locking groove 145 provided in holding portion 140. Therefore, in the standby state shown in FIG. 3 , operation portion 188 is maintained in a state in which it protrudes outside by maintenance mechanism 190, and spring member 165 is maintained in a compressed state by contact portion 181 of stopper 180.

[0054] 2, the insertion portion 183 can be configured, for example, as a substantially circular insertion hole 185. The insertion hole 185 is configured to have a size that allows the tip of the holding portion 140 provided in the pressing portion 130 to be inserted therethrough. The tip of the pressing portion 130 is provided with a pressing end (pressing surface) 131 that abuts against the base end 213 of the first prefilled syringe 210 in the driven state.

[0055] When the operator operates the assist mechanism 120 to start assisting the movement of the first plunger 211 of the first prefilled syringe 210 toward the tip side, as shown in FIG. 4, the operator operates the operating part 188 of the stopper 180 outside the syringe mounting fixture 110, and pushes the operating part 188 toward the other end side in the width direction (the side of the arrow Y1).

[0056] When stopper 180 is pushed into syringe mounting fixture 110 and moves to a position where insertion portion 183 (insertion hole 185) overlaps with holding portion 140 in the width direction, compression of spring member 165 is released and spring member 165 extends along the longitudinal direction of syringe mounting fixture 110. Holding portion 140 receives a biasing force from extended spring member 165 via flange portion 146.

[0057] 5, a portion of the distal end side of the holding part 140 passes through the insertion part 183, and the pressing end 131 of the holding part 140 abuts against the base end 213 of the first plunger 211 of the first prefilled syringe 210. The pressing part 130 generates an assist force that moves the first plunger 211 of the first prefilled syringe 210 forward toward the distal end via the pressing end 131 of the holding part 140. This allows the operator to smoothly move the first plunger 211 toward the distal end, and allows the liquid filled in the first cylindrical body 217 of the first prefilled syringe 210 to be quickly injected into the interior 410a of the first container 410.

[0058] The insertion portion 183 may have a structure other than a hole. For example, it may be configured as a notch formed in the stopper 180. Furthermore, in the above example, the contact between the contact portion 181 of the stopper 180 and the holding portion 140 is released by pushing the stopper 180 toward the other end side in the width direction of the syringe mounting fixture 110 (the Y2 side of the arrow), but this is not limiting. For example, it is also possible to configure the contact to be released by rotating the stopper 180 relative to the syringe mounting fixture 110, or to configure the contact to be released by pulling the stopper 180 outward from the syringe mounting fixture 110.

[0059] <First prefilled syringe 210, second prefilled syringe 220> As shown in FIGS. 3 to 5, the first prefilled syringe 210 has a first cylindrical body 217 filled with a predetermined liquid L1, and a first plunger 211 with a part of its tip inserted into the first cylindrical body 217.

[0060] A gasket 215 that can slide liquid-tightly inside the first cylindrical body 217 is attached to the tip of the first plunger 211. A seal member 219 is arranged at a discharge port provided at the tip of the first cylindrical body 217.

[0061] The second prefilled syringe 220 has a second cylindrical body 227 filled with a predetermined liquid L2, and a second plunger 221 with a part of the tip side inserted into the second cylindrical body 227.

[0062] A gasket 225 that can slide liquid-tightly inside the second cylindrical body 227 is attached to the tip of the second plunger 221. A seal member 229 is arranged at a discharge port provided at the tip of the second cylindrical body 227.

[0063] The liquids L1 and L2 are, for example, diluents (dissolving water) used to dilute the medicines M1 and M2 contained in the containers 410 and 420. The specific type of diluent is not particularly limited.

[0064] <First container 410, second container 420> 1, a first drug M1 is contained in an interior 410a of the first container 410. A seal member 413 is disposed at the opening of the first container 410.

[0065] 1, a drug M2 is contained in an interior 420a of the second container 420. A seal member 423 is disposed at the opening of the second container 420.

[0066] The first container 410 is configured to have a larger volume than the second container 420 so that the first container 410 can accommodate a larger volume of medication than the second container 420 .

[0067] In this embodiment, the first drug M1 contained in the interior 410a of the first container 410 has lower solubility than the second drug M2 contained in the second container 420. An example of such a combination of drugs M1 and M2 is where the first drug M1 is dextrin and the second drug M2 is sodium carbonate. Furthermore, for example, drugs M1 and M2 are freeze-dried preparations and can be contained in the containers 410 and 420 in powder form.

[0068] The assist mechanism 120 is configured to assist the movement of the first plunger 211 provided in the first prefilled syringe 210 filled with the liquid L1 to be injected into the interior 410a of the first container 410. Therefore, when dissolving the first drug M1 with low solubility, the operator can increase the amount of liquid delivered per unit time into the first container 410 by using the assist mechanism 120 to assist the movement of the first plunger 211. Therefore, the liquid L1 can be smoothly injected into the first container 410 holding the first drug M1 with low solubility. This allows the drug M1 to be efficiently dissolved without leaving the first drug M1 in a powder form near the bottom of the first container 410.

[0069] 3, the first cylindrical body 217 filled with the liquid L1 in the first prefilled syringe 210 has a larger diameter than the second cylindrical body 227 filled with the liquid L2 in the second prefilled syringe 220. In other words, the inner diameter D1 of the first cylindrical body 217 is larger than the inner diameter D2 of the second cylindrical body 227.

[0070] A powdered first drug M1, such as dextrin, requires a larger amount of diluent to reach a predetermined dilution concentration. Therefore, the first cylindrical body 217 of the first prefilled syringe 210, which injects the liquid L1 into the first container 410, may have a relatively large inner diameter D1 to accommodate a larger amount of liquid L1. However, as the inner diameter D1 of the first cylindrical body 217 increases, the sliding resistance required to move the gasket 215 also increases, requiring a larger pressing force to move the first plunger 211 within the first cylindrical body 217. Therefore, simply moving the first plunger 211 using the negative pressure preset in the interior 410a of the first container 410 may not smoothly and reliably push the first plunger 211 to the target pushing position of the first cylindrical body 217. Therefore, in this embodiment, an assist mechanism 120 is installed in the syringe mounting fixture 110 so as to assist the movement of the first plunger 211 of the first prefilled syringe 210 having the first cylindrical body 217 with a larger inner diameter D1.

[0071] <Container mounting device 300> 1, a first container 410 and a second container 420 can be attached to the container attachment tool 300. The container attachment tool 300 is also configured to be connectable to a liquid injection tool 100.

[0072] When starting the dilution (dissolution) of each of the drugs M1 and M2, each of the containers 410 and 420 is prepared in a state where it is attached to the container attachment tool 300 as shown in FIG.

[0073] The container mounting tool 300 is provided with an insertion port 311 into which the tip end of the first prefilled syringe 210 and the tip end of the second prefilled syringe 220 connected to the liquid injection tool 100 can be inserted.

[0074] The insertion port 311 is provided with a first insertion port 311a having a size corresponding to the outer diameter of the first prefilled syringe 210, and a second insertion port 311b having a size corresponding to the outer diameter of the second prefilled syringe 220.

[0075] The container mounting device 300 has a first double-ended needle 340 that, when connected to the liquid injection device 100, fluidly connects the interior of the first prefilled syringe 210 (the interior of the first cylindrical body 217) to the interior 410a of the first container 410, and a second double-ended needle 350 that fluidly connects the interior of the second prefilled syringe 220 (the interior of the second cylindrical body 227) to the interior 420a of the second container 420.

[0076] Each of the double-ended needles 340 and 350 is held by a needle holder 330 disposed inside the container mounting fixture 300 .

[0077] The first double-ended needle 340 has a needle tip 341 located on the first insertion opening 311a side and a needle tip 342 located on the first container 410 side.

[0078] The second double-ended needle 350 has a needle tip 351 located on the second insertion opening 311b side and a needle tip 352 located on the second container 420 side.

[0079] To begin diluting the drugs M1 and M2, the operator connects the liquid injection tool 100, to which the syringes 210 and 220 are attached, to the container attachment tool 300, to which the containers 410 and 420 are attached. Specifically, as shown in Fig. 1 , the liquid injection tool 100 is connected from the vertically upper side of the container attachment tool 300, and the syringes 210 and 220 are inserted into the container attachment tool 300 through the insertion ports 311.

[0080] When the operator inserts each syringe 210, 220 into the container mounting device 300 to a certain extent or more, the needle tip 341 of the first double-ended needle 340 penetrates the seal member 219 arranged at the discharge port of the first cylindrical body 217 (see FIG. 3). Similarly, the needle tip 351 of the second double-ended needle 350 penetrates the seal member 229 arranged at the discharge port of the second cylindrical body 227 (see FIG. 3).

[0081] When the operator further inserts each syringe 210, 220 into the container mounting device 300, the needle tip 342 of the first double-ended needle 340 pierces the seal member 413 arranged at the mouth of the first container 410. Similarly, the needle tip 352 of the second double-ended needle 350 pierces the seal member 423 arranged at the mouth of the second container 420.

[0082] By performing the above-described operations, the operator can communicate the interior of the first prefilled syringe 210 (the interior of the first cylindrical body 217) with the interior 410a of the first container 410 via the first double-ended needle 340, and can inject the liquid L1 from the first prefilled syringe 210 into the first container 410 by utilizing the negative pressure within the first container 410. Similarly, the operator can communicate the interior of the second prefilled syringe 220 (the interior of the second cylindrical body 227) with the interior 420a of the second container 420 via the second double-ended needle 350, and can inject the liquid L2 from the second prefilled syringe 220 into the second container 420 by utilizing the negative pressure within the second container 420.

[0083] As described above, the operator can start assistance by the assist mechanism 120 as needed while the operator is injecting the liquid L1 from the first prefilled syringe 210 into the first container 410. The timing of operating the assist mechanism 120 is not particularly limited, but for example, after activating the assist mechanism 120 to release the initial sliding of the gasket 215, the double-ended needles 340, 350 can be pierced through the sealing members 219, 229 of the syringes 210, 220 to start the injection of the liquid L1 from the first prefilled syringe 210 into the first container 410 and the injection of the liquid L2 from the second prefilled syringe 220 into the second container 420. Furthermore, for example, when the movement of the first plunger 211 has progressed to a certain extent and the movement of the first plunger 211 becomes extremely slow, or when the dissolution of the first drug M1 contained in the first container 410 takes longer than expected, the switching unit 170 can be appropriately operated to start assistance by the assist mechanism 120. Furthermore, for example, even if the negative pressure of the first container 410 is unintentionally released for some reason during puncture or the like, and automatic injection by negative pressure does not start even though the interior 410a of the first container 410 and the interior of the first prefilled syringe 210 are connected via the first double-ended needle 340, the operator can operate the assist mechanism 120 to smoothly inject the liquid L1 from the first prefilled syringe 210 into the first container 410.

[0084] In the above-described embodiment, the assist mechanism 120 is configured to assist the advancement (movement) of the first plunger 211 of the first prefilled syringe 210, but the object assisted by the assist mechanism 120 may be the second plunger 221 of the second prefilled syringe 220, or both the first plunger 211 of the first prefilled syringe 210 and the second plunger 221 of the second prefilled syringe 220.

[0085] When the assist mechanism 120 is configured to assist the movement of the second plunger 221 of the second prefilled syringe 220, for example, the layout of the assist mechanism 120 can be changed by shifting the position of the assist mechanism 120 from the position shown in each drawing to one end side in the width direction (the side of arrow Y2), so that the pressing part 130 can abut against the base end 223 of the second plunger 221. Furthermore, when the assist mechanism 120 is configured to assist the movement of the first plunger 211 of the first prefilled syringe 210 and the second plunger 221 of the second prefilled syringe 220, for example, two assist mechanisms 120 can be arranged side by side at different positions in the width direction of the syringe mounting fixture 110.

[0086] As described above, the liquid injection device 100 according to this embodiment comprises a syringe mounting fixture 110 capable of mounting the first prefilled syringe 210 prefilled with a predetermined liquid L1 to be injected into a first container 410, the interior of which is maintained at negative pressure and containing a predetermined drug M1, and the second prefilled syringe 220 prefilled with a predetermined liquid L2 to be injected into a second container 420, the interior of which is maintained at negative pressure and containing a predetermined drug M2, and a syringe mounting fixture 110 provided on the syringe mounting fixture 110, and an assist mechanism 120 that assists the movement of the first pusher 211 provided in the second prefilled syringe 220 toward the tip side and / or the movement of the second pusher 221 provided in the second prefilled syringe 220 toward the tip side, and the assist mechanism 120 has a pressing unit 130 that applies a pressing force toward the tip side to the base end 213 of the first pusher 211 and / or the base end 223 of the second pusher 221, a pressing drive unit 160 that generates the pressing force, and a switching unit 170 that enables switching from a standby state before the pressing force is generated to a drive state in which the pressing force is generated.

[0087] According to the liquid injection device 100 and drug dissolution kit 10 of this embodiment, by operating the switching unit 170 provided in the assist mechanism 120, the first plunger 211 of the first prefilled syringe 210 and / or the second plunger 221 of the second prefilled syringe 220 are applied with a pressing force from the pressing unit 130, thereby smoothly advancing the first plunger 211 and / or the second plunger 221. This allows the liquids L1 and L2 to be smoothly injected into the first container 410 and the second container 420, respectively, and makes it possible to dissolve the drugs M1 and M2 contained in the containers 410 and 420 in a short time.

[0088] The liquid injection device and drug dissolution kit according to the present invention have been described above through the embodiments, but the present invention is not limited to the contents described in the embodiments and can be modified as appropriate based on the claims.

[0089] In the embodiment, a drug dissolution kit that allows liquid to be injected from two prefilled syringes into two containers has been described, but the drug dissolution kit may be configured to connect at least two or more containers to two or more syringes. In other words, the drug dissolution kit may be configured to connect three or more containers to three or more syringes.

[0090] Furthermore, there are no particular limitations on the types of liquids and drugs described in the embodiments, and the use of the liquid injector (dilution of drugs), and these can be changed as desired as long as multiple prefilled syringes are used to inject a predetermined liquid into each of multiple containers for the purpose of mixing, stirring, diluting, etc. of the liquid and drug. For example, the drugs contained in different containers may be of the same type. [Explanation of symbols]

[0091] 10 Drug dissolution kit 100 Devices for liquid injection 110 Syringe attachment 120 Assist mechanism 130 Pressing section 131 Pressing end 140 Holding part 141 Large diameter section 143 Small diameter section 145 Locking groove 146 Flange 150 outer cylinder 151 Fixed protrusion 160 Pressing drive unit 165 Spring member 170 Switching section 180 Stopper 181 Contact part 183 Insertion part 185 Insertion hole 186 Locking protrusion 188 Operation section 190 Maintenance mechanism 210 No. 1 prefilled syringe 211 First pusher 213 Base end of first plunger 217 First cylinder 220 No. 2 Prefilled Syringe 221 Second pusher 223 Base end of second plunger 227 Second cylinder 300 Container mounting device 330 Needle holding part 340 1st double-ended needle 350 2nd double-ended needle 410 1st container 410a Inside of first container 420 2nd container 420a Inside the second container P1 initial position P2 release position D1 Inner diameter of the first cylinder D2 Inner diameter of second cylinder L1 liquid L2 liquid M1 First drug M2 Second drug

Claims

1. a syringe mounting device capable of mounting a first prefilled syringe and a second prefilled syringe, each prefilled with a predetermined liquid to be injected into a first container and a second container, each of which contains a predetermined drug and is maintained at a negative pressure; an assist mechanism that is provided in the syringe mounting fixture and assists the movement of a first pusher of the first prefilled syringe toward the tip side and / or the movement of a second pusher of the second prefilled syringe toward the tip side, The assist mechanism includes: a pressing portion that applies a pressing force toward a distal end side to the base end of the first pusher and / or the base end of the second pusher; a pressure drive unit that generates the pressure; a switching unit that enables switching from a standby state before the pressing force is generated to a driving state in which the pressing force is generated.

2. a first drug contained within the first container having a lower solubility than a second drug contained within the second container; 2. The liquid injection device according to claim 1, wherein the assist mechanism is configured to assist the movement of the first plunger provided in the first prefilled syringe filled with the liquid to be injected into the first container.

3. 3. The liquid injection device according to claim 2, wherein a first cylindrical body filled with the liquid in the first prefilled syringe has a larger diameter than a second cylindrical body filled with the liquid in the second prefilled syringe.

4. the pressing drive unit has a spring member that is expandable and contractible in an extension direction of the first pusher and the second pusher, the pressing portion has a holding portion that holds the spring member and to which the biasing force generated by the spring member is applied, the switching portion has a stopper that abuts against at least a part of the pressing portion in the standby state to maintain the spring member in a compressed state in the extension direction, The liquid injection device according to claim 1 , wherein the switching portion extends the spring member in the extension direction by releasing the stopper from contacting the pressing portion, thereby switching from the standby state to the driven state.

5. the stopper is attached to the syringe mounting fixture so as to be movable from an initial position in which the stopper is kept in contact with at least a part of the pressing portion to a release position in which the stopper is released from contact with the pressing portion, 5. The liquid injection device according to claim 4, wherein the stopper has an abutment portion that abuts against at least a portion of the pressing portion when the stopper is located at the initial position, and an insertion portion that is provided adjacent to the abutment portion and through which at least a portion of the pressing portion is inserted when the stopper moves to the release position, thereby enabling the spring member to extend as the pressing portion moves toward the tip side.

6. the stopper has an operation portion that is disposed outside the syringe mounting tool when the stopper is located at the initial position, The liquid injection device according to claim 5 , further comprising a maintaining mechanism that maintains the stopper in the initial position when no external force is applied to the operation portion.

7. The liquid injection device according to any one of claims 1 to 6, a container mounting tool to which the first container and the second container are mounted and which is configured to be connectable to the liquid injection tool, A drug dissolution kit, wherein the container attachment device has a first double-ended needle that, when connected to the liquid injection device, fluidly connects the inside of the first prefilled syringe with the inside of the first container, and a second double-ended needle that fluidly connects the inside of the second prefilled syringe with the inside of the second container.

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