Arthropod control composition

Abstract

The invention relates to arthropod control compositions, methods and uses for controlling arthropods, and arthropod control articles comprising the arthropod control compositions.

Description

[Technical field]

[0001] The present invention relates to arthropod control compositions, methods and uses for controlling arthropods, and arthropod control articles comprising the arthropod control compositions.

[0002] background Many mammals, including humans, are plagued by arthropod activity. Some arthropods, such as mosquitoes and ticks, are undesirable to mammals, particularly vertebrates such as human subjects, because they bite and can result in itching, disease and / or transmission of pathogens, or cause other diseases and / or conditions. Similarly, other pests affect human activities or society indirectly by feeding, infesting, or destroying plant materials used as food, feed, or raw materials. In addition, pests are responsible for the destruction or weakening of furniture or structures used or constructed by humans. These damages may be directly attributable to the arthropods or due to their ability to spread the pathogens that cause such problems.

[0003] The arthropod control composition includes an active material that, when applied to the skin, clothing, or other surface, can deter arthropods from landing or climbing on the surface. Arthropod control agents are useful, for example, in preventing and controlling the occurrence of arthropod-borne diseases, such as malaria.

[0004] However, some of the known arthropod control agents and compositions have certain drawbacks, such as having negative effects, i.e. negative olfactory properties, such as no odor or a foul odor, or only weak arthropod control properties, in particular arthropod repellent properties.

[0005] There is a need to provide arthropod control compositions that have both good olfactory properties, i.e., good hedonic effect, and good arthropod control properties, especially arthropod repellent properties.

[0006] The prior art does not disclose or suggest arthropod control compositions according to the present invention. [Brief description of the drawings]

[0007] [Figure 1] Figure 1. Percentage of mosquitoes Aedes aegypti that escaped from stimuli-treated chambers over time. The four stimuli were the solvent propane-1,2-diol (gray triangles and dotted lines), N,N-diethyl-meta-toluamide (medium grey diamonds), 2,6-dimethoxy-4-methylphenol (light grey squares) and 1,2,3-trimethoxy-5-propylbenzene (black circles). Each stimuli was injected into the treated chambers containing mosquitoes over a 40 min period by a forced evaporation system, allowing the mosquitoes to migrate to the untreated escape chambers. Each point represents the mean number of mosquitoes in the untreated chambers (n=57, 6, 4 and 4, respectively) ± SD at 10 min intervals.

[0008] Detailed Description The present invention provides an arthropod control composition, preferably an insect control composition, comprising a compound of the formula: in the form of any one of its stereoisomers or a mixture thereof. [ka] [In the formula, R 1 is a hydrogen atom, C 1~3 Alkyl group or C(=O)(O) n R 1 ', n is 0 or 1, and R 1 ' is C 1~3 is an alkyl group, R 2 is a hydrogen atom, a hydroxyl group, an acetyl group, a formyl group, a nitrile group, a methyl group, or a methoxy group, and R 3 is a hydrogen atom, C 4~7 Oxacycloalkyl or oxacycloalkenyl group (C 1~3 each optionally substituted with an alkyl or methylene group, C 1~5 Alkyl or C 2~5 Alkenyl group (oxo group, COOH group, acetate group, COOMe group, COOEt group or OR 3each optionally substituted with a ' group; 3 ' is a hydrogen atom or C 1~10 Alkyl group or C 2~10 alkenyl group, R 4 is a hydrogen atom or C 1~3 is an alkyl group, R 5 is a hydrogen atom, C 2~3 Alkenyl group, hydroxymethyl group or OR 5 ' group, R 5 ' is a hydrogen atom or C 1~3 is an alkyl group, or R 1 and R 4 When combined, CH 2 C(=O)CH 2 a methanediyl group or a 2-oxopropane-1,1-diyl group, however, - R 5 is a hydrogen atom, R 1 , R 2 and R 3 is not a hydrogen atom, - R 5 is a hydrogen atom, and R 1 is a hydrogen atom or a methyl group, and R 4 is a methyl group, R 3 is unsubstituted C 1~5 Alkyl or C 1~5 Not an alkenyl group, - R 3 When R is a formyl group, 1 and R 4 is not a methyl group, but R 5 is not a hydrogen atom, - R 1 is a hydrogen atom, and R 5 When R is a methoxy group, 3 is not a formyl group, an acetyl group, or a 2-carboxyvinyl group, - R 2 When R is a methoxy group, 3 is not a prop-1-en-1-yl group, - 4-hydroxy-3-methoxybenzaldehyde, 4-butoxymethyl-2-methoxyphenol, 4-(4-hydroxy-3-methoxyphenyl)-2-butanone, 3-(4-hydroxy-3-methoxyphenyl)prop-2-enal, 4-hydroxy-3-methoxybenzaldehyde and 3-(3,4-dimethoxyphenyl)prop-2-enoic acid are excluded.

[0009] Preferably, R 1 is a hydrogen atom, C 1~3 Alkyl group or C(=O)(O) n R 1 ', n is 0 or 1, and R 1 ' is C 1~3 is an alkyl group, R 2 is a hydrogen atom, a hydroxyl group, or a methoxy group, and R 3 is a hydrogen atom, C 4~7 Oxacycloalkyl or oxacycloalkenyl group (C 1~3 each optionally substituted with an alkyl or methylene group, C 1~5 Alkyl or C 2~5 Alkenyl group (oxo group, COOH group or OR 3 each optionally substituted with a ' group; 3 ' is C 1~10 Alkyl group or C 2~10 alkenyl group, R 4 is a hydrogen atom or C 1~3 is an alkyl group, R 5 is a hydrogen atom, C 2~3 Alkenyl group or OR 5 ' group, R 5 ' is C 1~3 is an alkyl group, or R 1 and R 4 When combined, CH 2 C(=O)CH 2 group, methanediyl group or 2-oxopropane-1,1-diyl group.

[0010] The term "optionally" is understood to mean that a particular group that is optionally substituted may or may not be substituted with a particular functional group.

[0011] The terms "alkyl" and "alkenyl" are understood to include branched and straight chain alkyl and alkenyl groups. The terms "alkenyl" and "oxacycloalkenyl" are understood to include one or two olefinic double bonds, preferably one olefinic double bond.

[0012] The term "oxo group" is understood to include any group of formula =O, i.e., ketones or aldehydes, etc. In other words, C optionally substituted with an oxo group. 1~5 An alkyl group is an alkyl group having 1 to 5 carbons, in which one of the carbon atoms, as well as the terminal carbon, may be substituted with a =O group in place of two hydrogen atoms.

[0013] The term "oxacycloalkyl or oxacycloalkenyl group" has its usual meaning in the art, i.e. a heterocyclic group in which the heteroatom is oxygen, for example a pyranyl or furanyl group.

[0014] For the sake of clarity, "any one of its stereoisomers or a mixture thereof" or similar expressions means the usual meaning understood by the skilled artisan, i.e. that the compound of formula (I) may be a pure enantiomer or a diastereomer. In other words, the compound of formula (I) may have one or several stereocenters, each of which may have two different stereochemistries (e.g. R or S). The compound of formula (I) may furthermore be in the form of a pure enantiomer or in the form of a mixture of enantiomers or diastereoisomers. The compound of formula (I) may be racemic or scalemic. Thus, the compound of formula (I) may be in the form of a single stereoisomer or a composition of matter that comprises or consists of various stereoisomers.

[0015] According to any one of the above embodiments of the present invention, the compound of formula (I) may have at least one double bond and may be in the form of its E or Z isomer, or a mixture thereof, for example the present invention includes a composition of matter consisting of one or more compounds of formula (I) having the same chemical structure but differing in the arrangement of the double bonds. In particular, compound (I) may be in the form of a mixture consisting of isomers E and Z, said isomer E making up at least 50%, alternatively at least 60%, alternatively at least 70%, alternatively at least 75% of the total mixture (i.e. a mixture E / Z comprised between 75 / 25 and 100 / 0).

[0016] According to any one of the above embodiments of the present invention, R 5 is R 5 ' is C 1~3 The alkyl group OR 5 In other words, the compound of formula (I) may be a group represented by the formula [ka] [In the formula, R 1 , R 2 , R 3 , R 4 and R 5 ' has the same meaning as defined above] In particular, R 5 R' is a methyl or ethyl group. More particularly, R 5 ' is a methyl group.

[0017] According to any one of the above embodiments of the present invention, R 1 is a hydrogen atom or C 1~3 In particular, R 1 may be a hydrogen atom, or a methyl or ethyl group. More particularly, R 1 may be a hydrogen atom or a methyl group.

[0018] According to any one of the above embodiments of the present invention, R 2may be a hydrogen atom.

[0019] According to any one of the above embodiments of the present invention, R 4 may be a methyl or ethyl group. More particularly, R 4 may be a methyl group.

[0020] According to any one of the above embodiments of the present invention, R 3 is hydrogen, C 4~5 an oxacycloalkyl or oxacycloalkenyl group, optionally substituted with methyl or methylene groups; 1~4 Alkyl or C 2~4 Alkenyl group (oxo group, COOH group or OR 3 each optionally substituted with a ' group; R 3 ' is C 1~10 It is an alkyl group.

[0021] To the best of the inventors' knowledge, the composition of the first aspect of the present invention has not previously been disclosed or suspected as having arthropod control properties.Furthermore, the compositions claimed herein have both arthropod control properties and a desirable hedonic profile, thus combining both fragrance properties and arthropod control properties in a single composition.

[0022] According to any one of the above embodiments of the present invention, the compound is 2,6-dimethoxy-4-[prop-1-enyl]phenol (CAS: 20675-95-0), 4-allyl-2,6-dimethoxyphenol (CAS: 98954-35-9), 1,2,3-trimethoxy-5-[1-propen-1-yl]benzene (CAS: 487-12-7), 1,2,3-trimethoxy-5-propylbenzene (CAS: 41564-88-9), 1,2,4-trimethoxybenzene (CAS: 135-77-3), 2,6-dimethoxy-4-propy 2,6-Dimethoxy-4-methylphenol (CAS: 6638-05-7), 3-(3,4,5-trimethoxyphenyl)prop-2-enoic acid (CAS: 90-50-6), 2-(4-hydroxy-3-methoxyphenyl)acetic acid (CAS: 306-08-1), methyl 3-(3,4-dimethoxyphenyl)-2-methylpropanoate (CAS: 148149-47-7), (2,3-dimethoxyphenyl)methanol (CAS: 5653-67-8), 2,3,4-trimethoxybenzaldehyde (CAS: 5653-67-8), aldehyde (CAS:2103-57-3), 3,4,5-trimethoxybenzaldehyde (CAS:86-81-7), 2-ethoxy-4-(methoxymethyl)phenol (CAS:5595-79-9), 2-ethoxy-4-(ethoxymethyl)phenol (CAS:71119-07-8), 1,2-dimethoxy-4-prop-1-enylbenzene (CAS:93-16-3), 1,2,3-trimethoxy-5-methylbenzene (CAS:6443-69-2), 2,6-dimethoxy-4-methylphenol (CAS:6638-05- 7), 1-(2,3,4-trimethoxyphenyl)ethanone (CAS: 13909-73-4), 7-methyl-1,5-benzodioxepin-3-one (CAS: 28940-11-6), 1,2-dimethoxy-3-prop-1-enylbenzene (CAS: 82895-28-1), 1,2,3-trimethoxy-5-propylbenzene (CAS: 41564-88-9), 2,3,4-trimethoxybenzonitrile (CAS: 43020-38-8), 3-ethoxy-4-methoxybenzaldehyde (CAS: 1131-52-8), 2,3,4-Trimethoxyphenol (CAS: 19676-64-3), 1-(4-hydroxy-3-methoxyphenyl)ethanone (CAS: 498-02-2), 2-methoxy-4-(4-methylideneoxan-2-yl)phenol (CAS: 128489-04-3), 4-(3,6-dihydro-4-methyl-2H-pyran-2-yl)-2-methoxy-phenol (CAS: 128489-02-1) and mixtures thereof.

[0023] More preferably, the compound is 6-dimethoxy-4-[prop-1-enyl]phenol (CAS: 20675-95-0), 4-allyl-2,6-dimethoxyphenol (CAS: 98954-35-9), 1,2,3-trimethoxy-5-[1-propen-1-yl]benzene (CAS: 487-12-7), 1,2,3-trimethoxy-5-propylbenzene (CAS: 41564-88-9), 1,2,4-trimethoxybenzene (CAS: 135-77-3), 2,6-dimethoxy-4-propylphenol (CAS: 6766-82-1), 2,6-dimethoxy-4-methylphenol (CAS: 6638-05-7), 3-(3,4,5-trimethoxyphenyl)prop-2-enoic acid. (CAS: 90-50-6), 2-(4-hydroxy-3-methoxyphenyl)acetic acid (CAS: 306-08-1), methyl 3-(3,4-dimethoxyphenyl)-2-methylpropanoate (CAS: 148149-47-7), (2,3-dimethoxyphenyl)methanol (CAS: 5653-67-8), 2,3,4-trimethoxybenzaldehyde (CAS: 2103-57-3), 3,4,5-trimethoxybenzaldehyde (CAS: 86-81-7), 2-ethoxy-4-(methoxymethyl)phenol (CAS: 5595-79-9), 2-ethoxy-4-(ethoxymethyl)phenol (CAS: 71119-07-8) and mixtures thereof.

[0024] A further aspect of the present invention provides an arthropod control composition, preferably an insect control composition, comprising 2-formyl-5-methoxyphenyl acetate [CAS:62536-84-9].

[0025] It can be understood that each of the embodiments of the present invention provided herein may not include 100% of the composition of the present invention.In such a situation, for example, additional ingredients can be used according to the needs of the expected use by the consumer to further improve the hedonic profile or to match the hedonic profile to the specific use by the consumer of the composition, solvents to assist in the delivery of the composition of the present invention, stabilizers and preservatives to improve the integrity and preservation of the composition.Further ingredients include additional arthropod control co-ingredients as presented below.

[0026] In a preferred embodiment of the present invention, the arthropod control composition has a good hedonic profile.

[0027] The inventors have appreciated that it may be desirable for an arthropod control composition to have an acceptable hedonic profile, since the composition may be used in close proximity to a consumer and, as can be appreciated, any unpleasant hedonic profile may inhibit use of the composition.

[0028] The term "arthropod" has its usual meaning to those skilled in the art. Arthropods include invertebrates with segmented bodies and articulated limbs, such as insects, arachnids, and crustaceans. Arthropods usually have a chitinous exoskeleton that is molted at intervals, and a dorsal anterior brain that connects to a ventral ganglion chain.

[0029] Arthropods in the context of the present invention refer to arthropods that are undesirable, i.e., their presence is undesirable in the air, on the surface of objects, on the surface of plants, or on the surface of vertebrates, such as human subjects or other mammals, preferably human subjects.Preferably, the undesirable arthropods are pest arthropods that affect plants and animals, such as thrips, aphids, beetles, moths, mealybugs, scale insects, etc., more preferably pest arthropods that affect animals, such as ants, termites, cockroaches, flies, etc., and even more preferably blood-sucking arthropods that affect vertebrates, such as stable flies, bedbugs, assassin bugs, fleas, lice, mosquitoes and ticks, more preferably mosquitoes and ticks.

[0030] The presence of arthropods may be undesirable because their presence in the air is unpleasant to the subject, contact of arthropods with items may transfer disease and / or pathogens, or arthropods may bite organisms causing itching and transmission of disease and / or pathogens, or the ingestion of arthropods may cause other diseases and / or conditions.

[0031] In certain embodiments, the arthropod is an insect or an arachnid, preferably an insect.

[0032] The term "insect" has its ordinary meaning to one of ordinary skill in the art. Insects are described by a distinct head, thorax and abdomen, only three pairs of legs, and usually one or two pairs of wings.

[0033] In certain embodiments, the insect is a mosquito, stable fly, bedbug, assassin bug, flea, lice, ant, termite, cockroach, fly, aphid, beetle, thrips, moth, mealybug or scale insect, more preferably a mosquito.

[0034] The term "arachnid" has its usual meaning to one of ordinary skill in the art. Arachnids have a segmented body divided into two regions, four pairs of legs in the front, but no antennae.

[0035] In a particular embodiment, the arachnid is a tick, a mite, a chigger or a spider, more preferably a tick.

[0036] Expressions such as "control", "arthropod control", "insect control" or "arachnid control" have their ordinary meaning to a person skilled in the art.

[0037] "Control" in the context of the present invention defines the ability of the arthropod control composition according to the present invention to attract, suppress, eliminate or repel arthropods, preferably to suppress or repel arthropods, and more preferably to repel arthropods.

[0038] "Attract" according to the present invention defines the ability of the arthropod attractant composition according to the present invention to increase or promote the contact or presence of arthropods at an arthropod attractant source, preferably an article such as a trapping device, to which the arthropod attractant compound or composition has been applied, for example in the air, on the surface of an article, or on the surface of a vertebrate, e.g., a human subject or other mammal.

[0039] "Repellency" according to the present invention defines the ability of an arthropod repellent composition according to the present invention to minimize, reduce, deter or prevent the approach or presence of arthropods at an arthropod repellent source to which the arthropod repellent compound or composition has been applied, e.g., in the air, on the surface of an article, or on the surface of a vertebrate, e.g., a human subject or other mammal, preferably a human subject.

[0040] "Inhibit" according to the present invention defines the ability of the arthropod control composition according to the present invention to minimize, reduce, deter or prevent the contact or presence of arthropods at an arthropod control source to which the arthropod control compound or composition has been applied, e.g., in the air, on the surface of an article, or on the surface of a vertebrate, e.g., a human subject or other mammal, preferably a human subject. Typically, after an initial taste of the arthropod control compound or composition, the inhibitory effect is exhibited when used as a feeding deterrent to prevent subsequent feeding or egg-laying or physical contact of the pest.

[0041] "Spatial repellency" according to the present invention defines the ability of the arthropod repellent composition according to the present invention to minimize, reduce, prevent or prevent the approach or presence of arthropods in the arthropod repellent source, for example, in the air, on the surface of an article, or on the surface of a vertebrate, for example, a human subject or other mammal, preferably a human subject, where the arthropod repellent compound or composition is applied.Generally, spatial repellency effect is shown when the spatial repellent compound or composition that is released, sprayed, scattered or diffused in the air or liquid prevents pests from entering the area where the spatial repellent compound or composition is present.Therefore, repellency occurs at a distance, and pests do not necessarily enter by directly contacting the article or organism that is treated for protection.

[0042] "Control" according to the present invention defines the ability of an arthropod-controlling composition according to the present invention to control arthropods on an arthropod control source, such as in the air, on the surface of an article, or on the surface of a vertebrate, such as a human subject or other mammal, preferably a human subject, to which the arthropod-controlling compound or composition is applied. When the arthropod-controlling composition is applied to a plant, animal, or human subject, it is applied in an amount that controls arthropods but does not kill the subject.

[0043] In certain embodiments, the arthropod control composition is an arthropod repellent composition, preferably an insect repellent composition, more preferably a mosquito repellent composition.

[0044] In certain embodiments, the arthropod control source is an article, preferably a candle, coil, air care product, preferably an electric diffuser, wristband, patch, collar, ear tag, clothing, fabric, paper, biochar, cardboard, cellulose pad, mosquito net, screen, curtain, furniture, wall, ground or paint, and / or the air, or the surface of a subject, preferably a vertebrate, such as a human subject or other mammal, preferably a human subject, i.e., the skin of a human subject treated with a product such as a spray, aerosol, cream, roll-on, wristband, lotion, soap, shampoo, sunscreen or patch, or fabric treated with a product such as a laundry powder, liquid detergent, spray, lotion, powder, etc.

[0045] Arthropod control efficacy of the present invention is determined against mosquitoes using an adapted Warm Body assay as defined in Kroeber T, Kessler S, Frei J, Bourquin M, Guerin PM. An in vitro assay for testing mosquito controlling compounds employing a warm body and carbon dioxide as a behavioral activator. J Am Mosq Control Assoc. 2010; 26:381-386. Further information is provided in the accompanying examples.

[0046] The control efficacy, repellency and spatial repellency according to the present invention are determined by testing thermophile assays against Aedes aegypti Rockefeller strain of Aedes aegypti. A. aegypti is a model organism for control testing and is one of the model organisms recommended by the World Health Organization (WHO) as it is a highly aggressive and anthropophilic species of mosquito that generally shows low sensitivity to arthropod control compounds. Observations of control efficacy were performed on host-seeking females of uniform age 5-10 days old, selected as mentioned in the above mentioned literature. The fasting females tested had access to a 10% sugar solution but no blood. Further information is presented in the attached examples.

[0047] The published protocol was adapted to count landed mosquitoes automatically instead of manually using automatic counting software, and by changing from Anopheles gambiae to A. aegypti, the number of mosquitoes placed in the test cages was reduced due to their size difference (i.e., 30 mosquitoes instead of 50) and the lighting was increased due to A. aegypti being a diurnal mosquito (i.e., 150 lux instead of 4 lux). Further information is provided in the accompanying examples.

[0048] The control, repellency and spatial repellency of the present invention are also determined according to the arm in the box method adapted from the WHO guidelines for testing the efficacy of mosquito repellents on human skin (WHO / CDS / NTD / WHOPES / 2009.4). The attitude of 100 hungry female mosquitoes A. aegypti to the test substance is evaluated by comparing the results of the untreated arm (negative control) and the treated arm when inserted into a cage (40 x 40 x 40 cm) for 30 seconds in triplicate. Further information is provided in the appended examples.

[0049] The activity of substances in repelling arachnids such as ticks can be evaluated using the in vitro Warm Plate Assay protocol defined in Kroeber T, Bourquin M, Guerin PM. 2013. A standardized in vivo and in vitro test method for evaluating tick repellents. Pestic. Biochem. Phys. 107(2):160-168.

[0050] In certain embodiments, the amounts and selection of agents are made to contribute, enhance or improve both the arthropod control activity and the hedonic properties of the composition.

[0051] In one embodiment, the arthropod control composition may further comprise an arthropod control co-ingredient. By "arthropod control co-ingredient" is understood an ingredient capable of imparting an arthropod control benefit in addition to the arthropod control effect of the compositions described herein.

[0052] In one embodiment, the substances described herein can modify, enhance or improve the arthropod control efficacy of an arthropod control co-ingredient, for example by reducing the amount of the arthropod control co-ingredient in the composition. This can be particularly beneficial when the arthropod control co-ingredient is harmful to human subjects at certain doses or when the arthropod control co-ingredient has negative olfactory properties at certain doses.

[0053] According to certain embodiments, the combination of a material described herein with an arthropod control co-ingredient provides a synergistic arthropod control effect.

[0054] According to certain embodiments, the combination of a substance described herein with an arthropod control co-ingredient results in an altered, pleasant, enhanced or improved olfactory impression of the overall composition compared to the single component.

[0055] According to one embodiment, the arthropod control co-ingredient is selected from the group consisting of N,N-diethyl-3-methylbenzamide (DEET), ethyl butylacetylaminopropionate (IR3535), para-menthane-3,8-diol (PMD), 1-(1-methylpropoxycarbonyl)-2-(2-hydroxyethyl)piperidine (picaridin), Chinese cedarwood oil, Texas cedarwood oil, Virginia cedarwood oil, cinnamon oil, citronella oil, corn mint oil, fractionated hydrated cyclized Cymbopogon winterianus oil, decanoic acid, hydrated cyclized Eucalyptus citriodora oil, eugenol, garlic oil, geraniol, geranium oil, lavender, Lavandula hybrida oil, and the like. hybrida) oil, lavandin oil, lemon oil, lemongrass oil, neem extract, metofluthrin, mixture of cis- and trans-p-menthane-3,8-diol, N,N-diethyl-meta-toluamide, nonanoic acid, rosemary oil, thyme oil, wintergreen oil, 2,3,4,5-bis(butyl-2-ene)tetrahydrofurfural (MGK Repellent 11), cineole, cinnamaldehyde, citronellal, citronellol, coumarin, dibutyl phthalate, diethyl phthalate, dimethyl anthranilate, dimethyl phthalate, ethyl vanillin, eucalyptus oil, δ-octalactone, δ-nonalactone, δ-decalactone, δ-undecalactone, δ-dodecalactone, γ-octalactone, γ-nonalactone, γ-decalactone, γ-undecalactone, γ-dodecalactone, hydroxycitronellal, lime oil, limonene, linalool, methyl anthranilate, mint oil, myrcene, neem oil, sabinene, β-caryophyllene, (1H-indol-2-yl)acetic acid, anethole, anise oil, basil oil, bay oil, camphor, ethyl salicylate, evergreen vegetable oil (Evergreen oils)(pine oil), (1,3,4,5,6,7-hexahydro-1,3-dioxo-2H-isoindol-2-yl)methyl 2,2-dimethyl-3-(2-methylprop-1-enyl)cyclopropanecarboxylate (d-tetramethrin), 3-allyl-2-methyl-4-oxocyclopent-2-enyl-2,2-Dimethyl-3-(2-methylprop-1-enyl)-cyclopropanecarboxylate (d-allethrin), α-cyano-3-phenoxybenzyl, 3-(2,2-dichlorovinyl)-2,2-dimethylcyclopropanecarboxylate (cypermethrin), 2-methyl-4-oxo-3-(prop-2-ynyl)cyclopent-2-en-1-yl 2,2-dimethyl-3-(2-methylprop-1-enyl)cyclopropanecarboxylate (prallethrin), acetamiprid, azadirachtin, bendiocarb, bifenthrin, boric acid, chlorpyrifos, deltamethrin, diazinon, dichlorvos, eugenol, fipronil, imidacloprid, linalool, malathion, maltodextrin, metofluthrin , Nicotine, Permethrin, Pyrethrins, Pyrethroids, Rotenone, Silicon Dioxide (Diatomaceous Earth), S-Methoprene, Spinosad (Spinosyn A), Spinosyn D, Tetramethrin, Transfluthrin, 1-(2,6,6-Trimethylcyclohex-2-en-1-yl)but-2-en-1-one, 3-Butylidene-2-benzofuran-1-one, 4-Ethenyl-2-Methoxyphenol, Konjac Green Oil, Labdanum Extract (Cistus Species), 5-Pentyloxolan-2-one, Chromen-2-one, 3,7-Dimethylocta-2,6-dienal, 4-Hydroxy-3-Methoxybenzaldehyde, 2-Methyl-5-prop-1-en-2-ylcyclohex-2-en-1-one, Mentha spicata (Mentha spicata oil, 6-hexyloxan-2-one, 5-methyl-2-propan-2-ylcyclohexyl]acetate, Nigella damascena oil, 2-phenylethanol, 6-pentyloxan-2-one, (4-methoxyphenyl)methyl acetate, Syzygium aromaticum oil, 3,4,4a,5,6,7,8,8a-octahydrochromen-2-one, 3,7,7-trimethylbicyclo[4.1.0]hept-3-ene, 2-phenylethyl 2-methylpropanoate, methyl 2-(3-oxo-2-pent-2-enylcyclopentyl)acetate, 4-(2-methoxypropan-2-yl)-1-methylcyclohexene, Mentha piperita oil, 2-methoxy-4-[prop-1-enyl]phenol, 2-methyl-3-(4-propan-2-ylphenyl)propanal, (4-methoxyphenyl)methanol and mixtures thereof.

[0056] In certain embodiments, the arthropod control co-ingredient is present in an amount of 0.02-80% by weight, more preferably 0.05-70% by weight, and even more preferably 0.1-60% by weight, based on the total weight of the composition, whereby it is understood that the composition comprises an arthropod control co-ingredient in a minimum amount of at least 0.02% by weight, at least 0.05% by weight, or at least 0.1% by weight, and a maximum amount of no more than 80% by weight, no more than 70% by weight, or no more than 60% by weight, based on the total weight of the composition.

[0057] In certain embodiments, within the limits of the amount of material in the composition as described above, the material and arthropod control co-ingredient in the composition of the present invention are included in the composition in a weight range of 90:10 to 10:90, preferably in a weight range of 80:20 to 20:80, more preferably in a weight range of 65:35 to 35:65, and most preferably in a weight range of 60:40 to 40:60. It is also understood herein that the material and arthropod control co-ingredient can be included in the composition in any combination of the weight ranges mentioned above, such as 90:10 to 20:80, preferably 35:65, more preferably 40:60, 80:20 to 10:90, preferably 35:65, more preferably 40:60, 65:35 to 10:90, preferably 20:80, more preferably 40:60, or 40:60 to 10:90, preferably 20:80, more preferably 35:65.

[0058] In one embodiment, the arthropod control composition may further comprise a fragrance component. It is understood that the fragrance component contributes to, modifies, enhances or improves the olfactory properties of the composition, but does not contribute to, enhance or improve the arthropod control effect of the composition. The fragrance components that produce such hedonic effects and are suitable for use in the compositions of the present invention are known in the art and can be easily identified by those skilled in the art.

[0059] The arthropod control composition may further comprise a carrier. By "carrier" is understood a material with which the active compound is mixed or formulated to facilitate its application to the locus or other object to be treated, or its storage, transport and / or handling. The carrier may be inorganic or organic, or synthetic, of natural origin. The carrier may be liquid or solid.

[0060] The liquid carrier may include, as a non-limiting example, solvents commonly used in emulsifying systems, i.e., solvent and surfactant systems, or perfumes.A detailed description of the nature and type of common solvents cannot be exhaustive.However, as a non-limiting example, it may include solvents such as butylene or propylene glycol, glycerol, dipropylene glycol and its monoethers, 1,2,3-propanetriyl triacetate, dimethyl glutarate, dimethyl adipate, 1,3-diacetyloxypropan-2-yl acetate, diethyl phthalate, isopropyl myristate, benzyl benzoate, benzyl alcohol, 2-(2-ethoxyethoxy)-1-ethanol, triethyl citrate, 2-methylprop-1-ene and 2-(2-ethoxyethoxy)ethanol, or mixtures thereof, with dipropylene glycol, 2-methylprop-1-ene and 2-(2-ethoxyethoxy)ethanol, and mixtures thereof being particularly suitable.

[0061] For compositions containing both carriers, suitable carriers other than those defined above may be ethanol, water / ethanol mixtures, limonene or other terpenes, isoparaffins such as those known under the trademark Isopar® (supplied by Exxon Chemical), or glycol ethers and glycol ether esters such as those known under the trademark Dowanol® (supplied by Dow Chemical Company) such as Dowanol® DPMA (glycol ether acetate), or hydrogenated castor oils such as those known under the trademark Augeo® Clean Multi (isopropylidene glycerol; supplied by Solvay), or Cremophor® RH 40 (supplied by BASF).

[0062] Solid carrier is intended to refer to a material to which the arthropod control composition or some elements of the arthropod control composition can be chemically or physically bound. Generally, such solid carriers are used to stabilize the composition or to control the evaporation rate of the composition or some components. The use of solid carriers is currently used in the art, and those skilled in the art are aware of how to achieve the desired effect. However, non-limiting examples of solid carriers can include absorbent gums or polymers or inorganic materials, such as porous polymers, cyclodextrins, wood-based materials, organic or inorganic gels, clays, gypsum talc, or zeolites.

[0063] Other non-limiting examples of solid carriers can include encapsulation materials.Examples of such materials can include wall-forming and plasticizing materials such as monosaccharides, disaccharides or trisaccharides, natural or modified starches, hydrocolloids, cellulose derivatives, polyvinyl acetate, polyvinyl alcohol, proteins or pectins, or other such materials.Encapsulation is a process known to those skilled in the art and can be carried out by using techniques such as spray drying, agglomeration, and even extrusion, or can consist of coating encapsulation, including coacervation and complex coacervation techniques.

[0064] Non-limiting examples of solid supports include core-shell capsules using aminoplast, polyamide, polyester, polyurea or polyurethane type resins, or mixtures thereof (all of which are known to those skilled in the art), using techniques such as phase separation processes induced by polymerization, interfacial polymerization, coacervation, or all together, optionally in the presence of polymeric stabilizers or cationic copolymers (all of which are described in the prior art).

[0065] The resins can be prepared by polycondensation of aldehydes (e.g. formaldehyde, 2,2-dimethoxyethanal, glyoxal, glyoxylic acid or glycolaldehyde, and mixtures thereof) with amines such as urea, benzoguanamine, glycoluril, melamine, methylolmelamine, methylated methylolmelamine, guanazole, and the like, and mixtures thereof. Alternatively, alkylolated polyamines can be used that are preformed resins, such as those commercially available under the trademarks Urac® (supplied by Cytec Technology Corp.), Cymel® (supplied by Cytec Technology Corp.), Urecoll® or Luracoll® (supplied by BASF).

[0066] Other resins are obtained by polycondensation of polyols such as glycerol with polyisocyanates such as the trimer of hexamethylene diisocyanate, the trimer of isophorone diisocyanate or the trimer of xylylene diisocyanate, or the biuret of hexamethylene diisocyanate, or the trimer of xylylene diisocyanate, and trimethylolpropane (known under the trademark Takenate®; supplier: Mitsui Chemicals), among others, with the trimer of xylylene diisocyanate, with trimethylolpropane and with the biuret of hexamethylene diisocyanate.

[0067] Many papers have been published on encapsulation by polycondensation of amino resins, i.e., melamine-based resins with aldehydes, which already describe the various parameters that influence the preparation of such core-shell microcapsules. These papers are known to those skilled in the art and their contents are used in the field of the present invention.

[0068] The present invention also relates to a method for controlling arthropods, preferably insects, which comprises directly contacting or contacting an arthropod, preferably an insect, with a vapor of the composition described above.

[0069] For clarity, the arthropod control compositions according to the present invention can be applied to the air, the surface of an article, the air adjacent to the surface of an article, or the surface of a subject by conventional methods known in the art, such as spraying, painting, wearing or spreading.

[0070] In certain embodiments, arthropod control compositions according to the invention are applied to the surface of an article, to the air adjacent to the surface of an article, or to the surface of an animal or subject.

[0071] In certain embodiments, the article may be an arthropod control article as described below, in particular a candle, a coil, an air care product, preferably an electric diffuser, a wristband, a patch, a collar, an ear tag, clothing, fabric, paper, biochar, cardboard, cellulose pads, mosquito nets, screens, curtains, furniture, paints, walls, ground, sprays, aerosols, creams, roll-ons, wristbands, lotions, soaps, shampoos, sunscreens, laundry powders, liquid detergents, sprays, lotions, powders.

[0072] In certain embodiments, the surface of the subject is a surface of a human or animal subject, preferably the surface is a human subject, i.e., the skin of a human subject.

[0073] The present invention also relates to the use of a composition as defined above for controlling arthropods, preferably insects.

[0074] The present invention also relates to arthropod control articles comprising the arthropod control compositions described above.

[0075] "Arthropod control article" is understood to refer to a consumer product that provides at least an arthropod control effect to the surface or space to which it is applied (e.g., skin, hair, fabric, or residential surface). In other words, the arthropod control article according to the present invention is a consumer product that includes a functional formulation, optionally an additional benefit agent corresponding to the desired consumer product, and an arthropod control amount of at least one of the substances. For clarity, the consumer product is a non-edible product.

[0076] The nature and type of components of the consumer product do not require a more detailed description herein and are in any case not comprehensive, but rather a person skilled in the art can select them on the basis of his general knowledge depending on the nature of said product and the desired effect.

[0077] Non-limiting examples of suitable consumer products include perfumes such as fine perfumes, splashes or eau de perfumes, colognes, or shave or aftershave lotions or creams or gels; fabric care products such as liquid or solid detergents, laundry detergent powders, fabric softeners, liquid or solid fragrance enhancers, fabric refreshers, ironing waters, paper, bleach, carpet cleaners, curtain care products, etc.; body care products such as hair care products (e.g. shampoos, coloring preparations or hair sprays, color care products, hair styling products), dental care products, disinfectants, intimate care products, etc.; cosmetics (e.g. skin creams or lotions, vanishing creams, or deodorants or antiperspirants (e.g. sprays or roll-ons), hair removers, tanning or sunscreen or after-sun products, nail products, skin cleansers, make-up products); or skin care products (e.g. soaps, shower or bath mousses, oils or gels, or hygiene products, or foot / hand care products); household products such as cosmetics, ... Air care products such as air fresheners or "ready to use" powdered air fresheners that can be used in indoor spaces (rooms, refrigerators, cupboards, shoes or cars) and / or public spaces (hall, hotel, mall, etc.); or home care products such as mould removers, furniture care products, wipes, dishwashing detergents or hard surface (e.g. floor, bathroom, toilet or window cleaner) cleaners; leather care products; car care products such as polishes, waxes or plastic cleaners; candles; sprays, coils, air care products, piezo devices Examples of suitable diffusers include candles, sprays, coils, electric diffusers, piezo diffusers, liquid electric diffusers, diffusers, rubber septa, wristbands, patches, collars, ear tags, clothing, fabric, paper, biochar, cardboard, cellulose pads, mosquito nets, screens, curtains, varnish or paint, and more preferably candles, sprays, coils, electric diffusers, piezo diffusers, liquid electric diffusers, diffusers, rubber septa, wristbands, patches, collars, ear tags, clothing, fabric, paper, biochar, cardboard, cellulose pads, mosquito nets, screens, curtains, varnish or paint.

[0078] In a preferred embodiment of the present invention, the consumer product is an air care product, preferably an electric diffuser. In this embodiment of the present invention, the substances in the arthropod control composition, preferably the insect control composition, are present in certain amounts.

[0079] Some of the abovementioned consumer products may represent aggressive media for the constituents of the substance, so that it may be necessary to protect the latter against premature degradation, for example by encapsulation or by chemically binding them with other chemicals suitable for releasing the components of the invention upon an appropriate external stimulus, such as enzymes, light, heat or a pH change.

[0080] The invention is further illustrated by the following non-limiting examples. EXAMPLES

[0081] 1. Experimental protocols and methods used herein The "thermosphere assay" is a small-scale test used to screen repellent efficacy against mosquitoes at T0 between 3 and 15 concentrations.

[0082] Aedes aegypti is a model organism for control testing and is one of the model organisms recommended by the World Health Organization (WHO) because it is a highly aggressive, anthropophilic mosquito species that generally shows low susceptibility to arthropod control compounds. Anopheles gambiae is also a model organism because it is anthropophilic and transmits malaria.

[0083] The control efficacy of the present invention was evaluated using an adapted thermophile assay as defined in Kroeber T, Kessler S, Frei J, Bourquin M, Guerin PM. 2010. J Am Mosq Control Assoc. 26:381-386. In this in vitro assay, the number of mosquitoes landing on a thermophile simulating an attractive host treated with a test stimuli was measured to evaluate the repellency effect.

[0084] The published protocol was adapted by changing from Anopheles gambiae to Aedes aegypti, which reduced the number of mosquitoes placed in the test cages due to their size difference (i.e., 30 mosquitoes instead of 50) and increased illumination (i.e., 150 lux instead of 4 lux) as A. aegypti is a diurnal mosquito.

[0085] The "dual chamber assay" is a small-scale test used to screen spatial repellent efficacy against mosquitoes at one concentration for 0-40 minutes.

[0086] The aim of this assay was to reproduce on a smaller scale the validation studies of spatial repellents described in WHO (2013; ISBN 978 92 4 150502 4).

[0087] The assay was carried out in a transparent cage (1200 × 755 × 700 mm; approximately 0.63 m) covered with white paper. 3). The cage is divided into two chambers of equal dimensions by a plasticized paper wall with a square opening (200 × 200 mm) located in the center of the wall. At the beginning of the experiment, about 40 2-week-old female Aedes aegypti mosquitoes are placed in the right chamber. After the mosquitoes have settled in this chamber (>5 min), the door between the chambers is opened. The stimuli are then introduced into the mosquito chamber through an L-shaped Teflon tube (40 mm) placed in the center of the right Plexiglas wall. The stimuli are delivered at a rate of 0.1 mL / min in a 1 L / min nitrogen flow by a forced evaporation system (Chappuis et al, 2015, DOI: 10.1021 / acs.est.5b00692) and mixed in a humidified air flow of 9 L / min before being transported to the L-shaped Teflon tube. An air intake system (approximately 150 L / min) is installed above an opening in the wall between the two chambers (100 mm φ) to prevent contamination of the untreated chamber with irritants and to limit accumulation of irritants in the treated chamber. The untreated chamber thus provides a "refuge" for mosquitoes to escape the irritants in the treated chamber. The number of mosquitoes that have migrated to the untreated chamber is manually counted 10, 20, 30 and 40 min after the start of irritant injection.

[0088] The "Arm-in-Cage Test" is a large-scale test used to evaluate repellent efficacy against mosquitoes in human volunteers.

[0089] The arm-in-box method was adapted from the WHO guidelines for efficacy testing of mosquito repellents on human skin (WHO / CDS / NTD / WHOPES / 2009.4). The readiness of 100 hungry female A. aegypti mosquitoes to probe is assessed by inserting the untreated arm (negative control) of a human volunteer into a cage (40 × 40 × 40 cm) for 30 s and determining the probing activity. The product is then applied to the skin of the forearm of the human volunteer (600 cm). 2After 5 min, the arm is inserted into the cage and exposed for 3 min. The assay is performed on 3 different human volunteers in a temperature (27±2° C.) and humidity (80±10% RH) controlled room.

[0090] The "Free Flying Room Assay" is a large-scale test used to evaluate spatial repellent efficacy against mosquitoes in human volunteers.

[0091] The aim of this large-scale study was to evaluate the tendency of an airborne irritant to protect human volunteers by limiting the presence of mosquitoes in the protected space and the number of landings / bites. The protocol used to carry out the study follows the guidelines given by WHO (2013; ISBN 978 92 4 150502 4).

[0092] One hour before the start of the test, 25m 3 A group of 50 female Aedes aegypti mosquitoes was placed in one of the chambers. 3 The product was applied to the other room (the "treated room") of the room and allowed to evaporate for 30 minutes. The test was started by opening the window separating the two rooms in a tilt-on fashion for a further 30 minutes. Twenty minutes after the window was opened, volunteers entered the "treated room" and sat for 10 minutes, exposing their forearms for the final 3 minutes to determine probing activity (protective efficacy). The connecting window was then closed and the number of mosquitoes in each room was counted (spatial repellency). Negative controls were performed following the same procedure without application of the irritant. Three replicates of each treatment and negative control were performed with three different volunteers.

[0093] The "hot plate assay" is a small-scale test used to screen the repellent efficacy against ticks at T0 at various concentrations.

[0094] The repellent efficacy of various compounds was evaluated against the castor bean tick Ixodes ricinus L., which can transmit both bacterial and viral pathogens. I. ricinus is one of the recommended model organisms listed in the Guidance on the European Biological Products Regulation [Vol II, Efficacy - Assessment & Evaluation (Parts B+C), v. 3.0, April 2018]. Repellent efficacy observations were performed against terminal nymphal stages.

[0095] Repellent efficacy was assessed using the in vitro hot plate assay protocol defined in Kroeber T, Bourquin M, Guerin PM. 2013. Pestic. Biochem. Phys. 107(2):160-168.

[0096] 2. Results of deterrent and spatial repellency effects on arthropods Hyperthermia assay Heat source (28.3cm 2 100 μL of compounds diluted to various concentrations in ethanol were applied to sandblasted glass Petri dishes covering the mosquitoes. The number of mosquitoes landing on the heater was counted for each stimulus and for pure ethanol (solvent) as a control.

[0097] All irritants tested induced a clear increase in repellency associated with increasing application dose (Tables 1, 2, 3 and 4), demonstrating the biological repellent effect of the different products on mosquito behaviour.

[0098] Table 1: Repellency of the mosquito Aedes aegypti on a hotbed containing various stimuli at various concentrations. The nine stimuli tested were 1,2,3-trimethoxy-5-[1-propen-1-yl]benzene

[1123] , 2,6-dimethoxy-4-[prop-1-enyl]phenol

[1124] , 4-allyl-2,6-dimethoxyphenol

[1191] , 1,2,3-trimethoxy-5-propylbenzene

[1975] , 2,6-dimethoxy-4-propylphenol

[1502] , 1-(3,4,5-trimethoxyphenyl)-N-[2-[(3,4,5-trimethoxyphenyl)methylideneamino]ethyl]methanimine

[1980] and (2-methoxy-4-methylphenyl)methyl carbonate

[1141] . Twelve to fifteen concentrations of each irritant were evaluated, and missing data points were noted as nd. The mean number of mosquito stops in the presence of vehicle alone (0 mg / mL) corresponded to 58 ± 3.3 stops over 2 min.

[0099] [Table 1]

[0100] As shown in Table 1, all seven compounds showed a concentration-related reduction in mosquito landings, although there was some variability in the measurements. Indeed, 4-allyl-2,6-dimethoxyphenol, 1,2,3-trimethoxy-5-[1-propen-1-yl]benzene, 1,2,3-trimethoxy-5-propylbenzene and 2,6-dimethoxy-4-propylphenol always limited the mosquito landings to less than 5 landings / min at all concentrations above 0.0178% (Table 1). 4-allyl-2,6-dimethoxyphenol showed highly relevant results, since it was able to reduce mosquito landings by more than 50% from the lowest concentration evaluated (Table 1). At the highest concentration tested (1%), all seven irritants, i.e., 1,2,3-trimethoxy-5-[1-propen-1-yl]benzene, 2,6-dimethoxy-4-[prop-1-enyl]phenol, 4-allyl-2,6-dimethoxyphenol, 1,2,3-trimethoxy-5-propylbenzene, 2,6-dimethoxy-4-propylphenol, 1-(3,4,5-trimethoxyphenyl)-N-[2-[(3,4,5-trimethoxyphenyl)methylideneamino]ethyl]methanimine, and (2-methoxy-4-methylphenyl)methyl carbonate, were able to reduce the number of perches by more than 90% (Table 1).

[0101] Table 2: Repellency of the mosquito Aedes aegypti to land on a heater containing various stimuli at different concentrations. The eight stimuli tested were 2,6-dimethoxy-4-prop-1-enylphenol

[1127] , 1,2,4-trimethoxybenzene

[1201] , 2,6-dimethoxy-4-methylphenol

[1537] and 3-(3,4,5-trimethoxyphenyl)prop-2-enoic acid

[1566] . Nine concentrations of each stimuli were evaluated. The mean number of mosquito stops in the presence of the vehicle alone (0 mg / mL) corresponds to 52 ± 2.1 times in 2 min.

[0102] [Table 2]

[0103] As shown in Table 2, 1,2,4-trimethoxybenzene was able to reduce the number of mosquito landings by a factor of two from the lowest doses tested (0.00032% and 0.0016%). At a dose of 1%, all four irritants tested, namely, 2,6-dimethoxy-4-prop-1-enylphenol, 1,2,4-trimethoxybenzene, 2,6-dimethoxy-4-methylphenol, and 3-(3,4,5-trimethoxyphenyl)prop-2-enoic acid, were able to reduce the number of mosquito landings from 29 times / min to less than 1 time / min (Table 2).

[0104] Table 3: Repellency of the mosquito Aedes aegypti on a hot plate containing various stimuli at various concentrations. The 49 stimuli tested were 7-propyl-1,5-benzodioxepin-3-one

[0465] , 1-(5-propyl-1,3-benzodioxol-2-yl)ethanone

[0908] , 1,2-dimethoxy-3-prop-1-enylbenzene

[1125] , 1,2,3-trimethoxy-5-prop-1-enylbenzene

[1126] , 1,2-dimethoxy-4-prop-1-enylbenzene

[1195] , 1,4-dimethoxy-2-[1-propen-1-yl]benzene

[1196] , 2,3,4-trimethoxy-5-prop-1-enylbenzene

[1197] , 1,4-dimethoxy-2-[1-propen-1-yl]benzene

[1198] , 1,5-trimethoxy-2-[1-propen-1-yl]benzene

[1199] , 1,6-trimethoxy-2-[1-propen-1-yl]benzene

[1200] , 1,7-trimethoxy-2-[1-propen-1-yl]benzene

[1201] , 1,8-trimethoxy-2-[1-propen-1-yl]benzene

[1202] , 1,9-trimethoxy-2-[1-propen-1-yl]benzene

[1203] , 1,2-trimethoxy-2-[1-propen-1-yl]benzene

[1204] , 1,3-trimethoxy-2-[1-propen-1-yl]benzene

[1205] , 1,4-trimethoxy-2-[1-propen-1-yl]benzene

[1206] , 1,5-trimethoxy-2-[1-propen-1-yl]benzene

[1207] 1-(4-hydroxy-3-methoxyphenyl)ethanone

[1468] , (2-ethoxy-4-formylphenyl)2-acetaldehyde

[1469] , 1-(4-hydroxy-3-methoxyphenyl)ethanone

[1470] , (2-ethoxy-4-formylphenyl)2-acetaldehyde

[1471] , 1-(4-hydroxy-3-methoxyphenyl)ethanone

[1472] , (2-ethoxy-4-formylphenyl)2-acetaldehyde

[1473] , 1-(4-hydroxy-3-methoxyphenyl)ethanone

[1474] , (2-ethoxy-4-formylphenyl)2-acetaldehyde

[1475] , 1-(4-hydroxy-3-methoxyphenyl)ethanone

[1476] , (2-ethoxy-4-formylphenyl)2-acetaldehyde

[1477] , 1-(4-hydroxy-3-methoxyphenyl)ethanone

[1478] , (2-ethoxy-4-formylphenyl)2-acetaldehyde

[1479] , 1-(4-hydroxy-3-methoxyphenyl)ethanone

[1480] , (2-ethoxy-4-formylphenyl)2-acetaldehyde

[1481] , 1-(4-hydroxy-3-methoxyphenyl)ethanone

[1482] , (2-ethoxy-4-formylphenyl)2-acetaldehyde

[1476] , 1-(4-hydroxy-3-methoxyphenyl)ethanone

[1477] , (2-ethoxy-4-formylphenyl)2-acetaldehyde

[1478] , 1-(4-hydroxy-3-methoxyphenyl)ethanone

[1479] , (2-ethoxy-4-formylphenyl)2-acetaldehyde

[1479] , 1-(4-hydroxy-3-methoxyphenyl)ethanone

[1483] , (2-ethoxy-4-formylphenyl)2-acetaldehyde

[1479] , 1-(4 -Methylpropanoate

[1469] , (2-formyl-5-methoxyphenyl)acetate

[1472] , 4-(3,6-dihydro-4-methyl-2H-pyran-2-yl)-2-methoxy-phenol and 2-methoxy-4-(4-methylideneoxan-2-yl)phenol blend

[1474] , 2-methoxy-4-(5-methyl-3,6-dihydro-2H-pyran-2-yl)phenol

[1478] , 4-[(allyloxy)methyl]-2-ethoxyphenol

[1479] , 2-methoxy-4-( 1-Methoxyethyl)phenol

[1480] , 2-Methoxy-4-(oxolan-2-yl)phenol

[1481] , 2-Ethoxy-4-(ethoxymethyl)phenol

[1482] , 4-{3-[(2,6-dimethyl-7-octen-2-yl)oxy]-1-propen-1-yl}-2-methoxyphenol

[1519] , 3-(4-hydroxy-3-methoxyphenyl)prop-2-enal

[1527] , 8-hydroxy-7-methoxychromen-2-one

[1551] , 3-(4-hydroxy-3,5-dimethoxyphenyl)prop-2-enoic acid

[1553] , 2,4-dimethoxyacetophenone

[1557] , 2,4-dimethoxybenzaldehyde

[1558] , 2-hydroxy-4-methoxyacetophenone

[1559] , 3-(3,4-dimethoxyphenyl)propanoic acid

[1561] , 2-(3,4-dimethoxyphenyl)acetic acid

[1564] , 2-(4-hydroxy-3-methoxyphenyl)acetic acid

[1567] , 1,2,3-trimethoxy-5-prop-2-enylbenzene

[1682] , methyl 3-(3,4-dimethoxyphenyl)-2-methylpropanoate

[1698] , 1,2,3-trimethoxybenzene

[1822] , 3,4,5-trimethoxytoluene

[1967] , (3,4,5-trimethoxyphenyl)methanol

[1968] , 4- These were ethyl-2,6-dimethoxyphenol

[2240] , 2,6-dimethoxyphenol

[2244] , 3-(3,4,5-trimethoxyphenyl)-2-propenyl acetate

[2247] , 1,2,3-trimethoxy-5-methylbenzene

[2250] , (2,3-dimethoxyphenyl)methanol

[2263] , 2,3,4-trimethoxybenzonitrile

[2266] , 2,3,4-trimethoxybenzaldehyde

[2267] , 3,4,5-trimethoxybenzaldehyde

[2268] , 1-(2,3,4-trimethoxyphenyl)ethanone

[2269] , 4-hydroxy-3,5-dimethoxybenzoic acid

[2270] , 3-ethoxy-4-methoxybenzaldehyde

[2272] and 2-ethoxy-1,3-dimethoxybenzene

[2276] . Three concentrations of each stimulant were evaluated. The mean number of mosquito landings in the vehicle alone (0 mg / mL) was equivalent to 59 ± 8 landings over 2 min.

[0105] [Table 3-1] [Table 3-2]

[0106] At the lowest concentration of 0.0016%, 19 irritants were detected, namely, 2-hydroxy-4-methoxyacetophenone, 2,4-dimethoxybenzaldehyde, 2,4-dimethoxyacetophenone, 3-(4-hydroxy-3-methoxyphenyl)prop-2-enal, 4-{3-[(2,6-dimethyl-7-octen-2-yl)oxy]-1-propen-1-yl}-2-methoxyphenol, 4-hydroxy-3,5-dimethoxybenzoic acid, 2-methoxy-4-(1-methoxyethyl)phenol, (2-ethoxy-4-formylphenyl)2-methylpropanoate, and 1-(4-hydroxy-3-methoxyphenyl)ethenone. , 3-(4-hydroxy-3,5-dimethoxyphenyl)prop-2-enoic acid, 3,4,5-trimethoxybenzaldehyde, 1,4-dimethoxy-2-[1-propen-1-yl]benzene, 1,2-dimethoxy-4-prop-1-enylbenzene, 4-[(allyloxy)methyl]-2-ethoxyphenol, 8-hydroxy-7-methoxychromen-2-one, 2-(4-hydroxy-3-methoxyphenyl)acetic acid, 7-methyl-1,5-benzodioxepin-3-one, 1,2,3-trimethoxybenzene and (2,3-dimethoxyphenyl)methanol were able to reduce the number of landings by more than 50% (Table 3). At this concentration, three irritants, namely 2,4-dimethoxyacetophenone, 2,4-dimethoxybenzaldehyde and 2-hydroxy-4-methoxyacetophenone, were even able to induce a repellent effect of more than 80% (Table 3).

[0107] At the intermediate concentration of 0.04%, 22 irritants were detected, namely, 1,2-dimethoxy-3-prop-1-enylbenzene, 2,3,4-trimethoxyphenol, 2-ethoxy-4-(methoxymethyl)phenol, 2-(4-hydroxy-3-methoxyphenyl)acetaldehyde, (2-formyl-5-methoxyphenyl)acetate, a blend of 4-(3,6-dihydro-4-methyl-2H-pyran-2-yl)-2-methoxy-phenol and 2-methoxy-4-(4-methylideneoxan-2-yl)phenol, 2-methoxy-4-(5-methyl-3,6-dihydro-2H-pyran-2-yl)phenol, 4-[(allyloxy)methyl]-2-ethoxyphenol, 2-methoxy-4-(oxolan-2-yl)phenol, 2-ethoxy-4-(methylphenyl)acetaldehyde, 2-formyl-5-methoxyphenylacetate, 4-(3,6-dihydro-4-methyl ...2-ethoxy-4-(methylphenyl)acetaldehyde, 2-formyl-5-methoxyphenylacetate, 4-(3,6-dihydro-4-methyl-2H-pyran-2-yl)phenol, 2-ethoxy-4-(methylphenyl)acetaldehyde, 2-formyl-5-methoxyphenylacetate, 4-(3,6-dihydro-4-methyl-2H-pyran-2-yl)phenol, 2-ethoxy-4-(methylphenyl)acetaldehyde, 2-formyl-5-methoxyphenylacetate, 4-(3, Di-4-(ethoxymethyl)phenol, 3-(4-hydroxy-3-methoxyphenyl)prop-2-enal, 3-(4-hydroxy-3,5-dimethoxyphenyl)prop-2-enoic acid, 2,4-dimethoxyacetophenone, 2,4-dimethoxybenzaldehyde, 2-hydroxy-4-methoxyacetophenone, 2-(4-hydroxy-3-methoxyphenyl)acetic acid, methyl 3-(3,4-dimethoxyphenyl)-2-methylpropanoate, (2,3-dimethoxyphenyl)methanol, 2,3,4-trimethoxybenzonitrile, 2,3,4-trimethoxybenzaldehyde, 3,4,5-trimethoxybenzaldehyde and 3-ethoxy-4-methoxybenzaldehyde were able to induce more than 75% repellency (Table 3).

[0108] At the highest concentration tested, i.e., 1%, the 30 compounds tested, namely, methyl 3-(3,4-dimethoxyphenyl)-2-methylpropanoate, (2-formyl-5-methoxyphenyl)acetate, 7-methyl-1,5-benzodioxepin-3-one, 1-(2,3,4-trimethoxyphenyl)ethenone, 1,2-dimethoxy-4-prop-1-enylbenzene, 2-methoxy-4-(1-methoxyethyl)phenol, 1,2,3-trimethoxyphenyl, 1,2-dimethoxy-4-prop-1-enylbenzene, 2-methoxy-4-(1-methoxyethyl)phenol, 1,2,3-trimethoxyphenyl, 1,2-dimethoxy-4-prop-1-enylbenzene, 1,2-dimethoxy-4-(1-methoxyethyl)phenol, 1,2,3-trimethoxyphenyl ... Methoxy-5-methylbenzene, 1,2,3-trimethoxybenzene, (3,4,5-trimethoxyphenyl)methanol, 2-ethoxy-4-methylphenol, 3-(3,4,5-trimethoxyphenyl)-2-propenyl acetate, 2-ethoxy-1,3-dimethoxybenzene, 2-hydroxy-4-methoxyacetophenone, 2-(4-hydroxy-3-methoxyphenyl)acetic acid, 4-[(allyloxy)methyl]-2-ethoxyphenol, 2-methyl 2-Ethoxy-4-(oxolan-2-yl)phenol, (2,3-dimethoxyphenyl)methanol, 2,4-dimethoxyacetophenone, 2-ethoxy-4-(methoxymethyl)phenol, 2,3,4-trimethoxybenzaldehyde, 2-ethoxy-4-(ethoxymethyl)phenol, 4-{3-[(2,6-dimethyl-7-octen-2-yl)oxy]-1-propen-1-yl}-2-methoxyphenol, 3,4,5-trimethoxybenzaldehyde Hydride, (2-ethoxy-4-formylphenyl) 2-methylpropanoate, 4-ethyl-2,6-dimethoxyphenol, 1,2-dimethoxy-3-prop-1-enylbenzene, 2,3,4-trimethoxyphenol, 8-hydroxy-7-methoxychromen-2-one, 1,2,3-trimethoxy-5-prop-2-enylbenzene and 1,2,3-trimethoxy-5-prop-1-enylbenzene were able to induce more than 90% repellency, i.e. less than 3 mosquitoes per minute compared to 29 mosquitoes per minute when no stimulant was applied (Table 3).Ten stimuli tested, namely methyl 3-(3,4-dimethoxyphenyl)-2-methylpropanoate, (2-formyl-5-methoxyphenyl)acetate, 7-methyl-1,5-benzodioxepin-3-one, 1-(2,3,4-trimethoxyphenyl)ethenone, 1,2-dimethoxy-4-prop-1-enylbenzene, 2-methoxy-4-(1-methoxyethyl)phenol, 1,2,3-trimethoxy-5-methylbenzene, 1,2,3-trimethoxybenzene, (3,4,5-trimethoxyphenyl)methanol and 2-ethoxy-4-methylphenol, were able to remain attractive stimuli for mosquito landing within 2 min of the experiment (Table 3).

[0109] Table 4: Repellency of the mosquito Anopheles gambiae on a hotbed baited with various stimuli at various concentrations. The eight stimuli tested were 1-(5-propyl-1,3-benzodioxol-2-yl)ethanone (908), 7-methyl-1,5-benzodioxepin-3-one (1228), isopropyl-2H,4H-1,5-benzodioxepin-3-one,7-(1232), 2-(3,4-dimethoxyphenyl)acetic acid (1564), 3,4,5-trimethoxytoluene (1967), (2-methoxy-4-methylphenyl)methyl carbonate (1141), 2-ethoxy-4-(methoxymethyl)phenol (1271), and 1-(4-hydroxy-3-methoxyphenyl)ethanone (1468). Two to five concentrations of each stimuli were evaluated. nd means no data. The mean number of mosquito landings in the presence of vehicle alone (0 mg / mL) corresponds to 46 ± 9.4 times in 2 min.

[0110] [Table 4]

[0111] At the two highest concentrations tested, i.e. 0.447% and 1%, the repellency rate was above 75% for all products at least at one of the two concentrations (Table 4). 7-Methyl-1,5-benzodioxepin-3-one, 3,4,5-trimethoxytoluene and (2-methoxy-4-methylphenyl)methyl carbonate were able to provide an attractive stimuli for mosquitoes at at least one of these two concentrations, i.e. 100% repellency, indicating the high repellency efficacy of the ingredients against Anopheles gambiae (Table 4). For 3,4,5-trimethoxytoluene, the repellency rate was already above 60% at the lowest concentration tested, i.e. 0.0178% (Table 4).

[0112] Table 5: Repellency of the mosquito Anopheles gambiae to land on a heater containing various stimuli at different concentrations. The three stimuli tested were 7-methyl-1,5-benzodioxepin-3-one (1228), 3,4,5-trimethoxytoluene (1967) and 1,2,3-trimethoxy-5-propylbenzene (1975). Nine concentrations of each stimuli were evaluated. nd means no data. The mean ± SD number of mosquito stops in the presence of the vehicle alone (0 mg / mL) corresponds to 51.3 ± 5.8 times in 2 min.

[0113] [Table 5]

[0114] When the concentration of the irritant applied to the hot body was 0.2% or more, the number of landings of malaria mosquitoes was reduced by more than 90% (Table 5). 3,4,5-trimethoxytoluene was even able to show more than 50% repellency at concentrations of 0.0178% or more, and no landing was possible at concentrations of 0.2% or more (Table 5). 1,2,3-trimethoxy-5-propylbenzene showed more than 90% repulsion at all doses of 0.04% or more applied to the hot body (Table 5).

[0115] Dual chamber assay As shown in Figure 1, treatment of chambers containing Aedes aegypti mosquitoes with the solvent used to dilute the three irritants, N,N-diethyl-meta-toluamide (DEET), 2,6-dimethoxy-4-methylphenol and 1,2,3-trimethoxy-5-propylbenzene, i.e., propane-1,2-diol, did not induce a strong migration to the untreated chambers; only 19.5% ± 4.8% of the mosquitoes migrated to the escape chamber after 40 min. Unexpectedly, the results with DEET were similar, with only 16.2% ± 7.3% migrating to the escape chamber 40 min after injection into the treated chambers containing mosquitoes (Figure 1). On the other hand, both products covered by this patent showed rapid and strong repellency, removing more than 30% of the mosquitoes within the first 10 minutes after injection and reaching a plateau of close to 42% and 54% for 2,6-dimethoxy-4-methylphenol and 1,2,3-trimethoxy-5-propylbenzene, respectively, 30 minutes after injection (Figure 1).

[0116] Arm-in-cage assay Table 6: Arm Incubation Results for Three Human Volunteers Who Had Their Arms Treated with 20% 1,2,3-Trimethoxy-5-Propylbenzene [Table 6]

[0117] As shown in Table 6, application of 1,2,3-trimethoxy-5-propylbenzene was able to protect the arms of all three human volunteers by reducing the number of landings by the mosquito Aedes aegypti by 99.4% ± 0.4%.

[0118] Table 7: Arm-in cage results over time for three human volunteers whose arms were treated with 20% 7-methyl-1,5-benzodioxepin-3-one [Table 7]

[0119] As shown in Table 7, application of 7-methyl-1,5-benzodioxepin-3-one provided a complete protection time (no perching observed) of 1.33 hours against Anopheles gambiae. At 3 hours, protection was still 79.64% in two volunteers (Table 7). It is noteworthy that IR3535, a commonly used repellent, provided only a CPT of 0.17 hours at the same concentration and using the same protocol (data not shown).

[0120] Free-Flying Room Assay Table 8: Aerial repellency efficacy of three compounds against Aedes aegypti in a large-scale assay.

[0121] [Table 8]

[0122] In the negative control test, i.e. when the room in which the volunteer was present was not treated with any irritant, 82.5±3.7% of the mosquitoes migrated from the release room through the window into the room in which the volunteer was present. They landed on the volunteer 60.7±2.5 times in 3 minutes, and the mosquitoes in the room landed and attempted to bite the volunteer 1.4±0.1 times. As shown in Table 8, all three compounds tested significantly reduced the intrusion of mosquitoes into the room in which the volunteer was present, reducing the number of potential bites by more than 60% compared to the situation in the untreated room. With 2,6-dimethoxy-4-methylphenol, only 29.5±2.8% of the mosquitoes entered the treated room and only 14.7±2.5 mosquitoes landed on the volunteer, resulting in the protection values ​​listed in Table 8. For 3,4,5-trimethoxytoluene, only 43.5 ± 3.2% of mosquitoes entered the treated rooms and 22.3 ± 3.2 mosquitoes landed on the volunteers, giving the protective values ​​listed in Table 8. For 1,2,3-trimethoxy-5-propylbenzene, only 46.3 ± 7.5% of mosquitoes entered the treated rooms and 15.7 ± 3.1 mosquitoes landed on the volunteers, giving the protective values ​​listed in Table 8.

[0123] Hot plate assay Table 9: Repellency of ticks Ixodes ricinus on a hot plate baited with three different concentrations of irritants.

[0124] [Table 9]

[0125] As shown in Table 9, 1,2-dimethoxy-3-prop-1-enylbenzene was able to repel the tick Ixodes ricinus in a dose-dependent manner, reaching a total of over 90% repellency with application of 1% irritant.

[0126] Table 10: Repellency of the tick Ixodes ricinus on a hot plate baited with 12 stimuli at three different concentrations. The 12 stimuli tested were (2-methoxy-4-methylphenyl)methyl carbonate

[1141] , 4-allyl-2,6-dimethoxyphenol

[1191] , 1,2-dimethoxy-4-prop-1-enylbenzene

[1195] , 1,2,4-trimethoxybenzene

[1201] , (2-formyl-5-methoxyphenyl) acetate

[1472] , 4-[(allyloxy)methyl]-2- Ethoxyphenol

[1479] , 2-ethoxy-4-(ethoxymethyl)phenol

[1482] , 2,6-dimethoxy-4-methylphenol

[1537] , 2,4-dimethoxyacetophenone

[1557] , 2,4-dimethoxybenzaldehyde

[1558] , 2-hydroxy-4-methoxyacetophenone

[1559] , and 2,3,4-trimethoxybenzaldehyde

[2267] .

[0127] [Table 10]

[0128] As shown in Table 10, all 12 irritants were able to repel the tick Ixodes ricinus depending on the dose. All 12 irritants repelled at least two-thirds of the ticks tested at the highest concentration tested of 1%. Furthermore, five compounds, 1,2-dimethoxy-4-prop-1-enylbenzene, 1,2,4-trimethoxybenzene, (2-formyl-5-methoxyphenyl)acetate, 4-[(allyloxy)methyl]-2-ethoxyphenol and 2-ethoxy-4-(ethoxymethyl)phenol, were able to repel all ticks at this 1% concentration (Table 10). 4-[(allyloxy)methyl]-2-ethoxyphenol was the most effective test compound since it already repelled two-thirds of the ticks tested at the lowest tested concentration of 0.04%, followed by all ticks at the two subsequent tested concentrations of 0.2% and 1% (Table 10).

Claims

1. An arthropod control composition, preferably an insect control composition, comprising a compound of formula (I) in the form of any one of its stereoisomers or a mixture thereof. 【Chemistry 1】 [In the formula, R １ is a hydrogen atom, C １～３ Alkyl group or C(=O)(O) ｎ R １ ', n is 0 or 1, and R １ ' is C １～３ is an alkyl group, and R ２ is a hydrogen atom, a hydroxy group, an acetyl group, a formyl group, a nitrile group, a methyl group, or a methoxy group, and R ３ is a hydrogen atom, C ４～７ an oxacycloalkyl or oxacycloalkenyl group (C １～３ each optionally substituted with an alkyl or methylene group), C １～５ Alkyl or C ２～５ Alkenyl group (oxo group, COOH group, acetate group, COOMe group, COOEt group or OR ３ each optionally substituted with a ' group, and R ３ ' is a hydrogen atom or C １～１０ Alkyl group or C ２～１０ is an alkenyl group, and R ４ is a hydrogen atom or C １～３ is an alkyl group, and R ５ is a hydrogen atom, C ２～３ Alkenyl group, hydroxymethyl group or OR ５ ' group, and R ５ ' is a hydrogen atom or C １～３ is an alkyl group, or R １ and R ４ When combined, CH ２ C(=O)CH ２ group, methanediyl group, or 2-oxopropane-1,1-diyl group, however, -R ５ is a hydrogen atom, R １ , R ２ and R ３ is not a hydrogen atom, -R ５ is a hydrogen atom, and R １ is a hydrogen atom or a methyl group, and R ４ is a methyl group, R ３ is unsubstituted C １～５ Alkyl or C １～５ Not an alkenyl group -R ３ is a formyl group, R １ and R ４ is not a methyl group, but R ５ is not a hydrogen atom, -R １ is a hydrogen atom, and R ５ is a methoxy group, R ３ is not a formyl group, an acetyl group, or a 2-carboxyvinyl group, -R ２ is a methoxy group, R ３ is not a prop-1-en-1-yl group, 4-hydroxy-3-methoxybenzaldehyde, 4-butoxymethyl-2-methoxyphenol, 4-(4-hydroxy-3-methoxyphenyl)-2-butanone, 3-(4-hydroxy-3-methoxyphenyl)prop-2-enal, 4-hydroxy-3-methoxybenzaldehyde, and 3-(3,4-dimethoxyphenyl)prop-2-enoic acid are excluded.

2. The compound of formula (I) is of the formula 【Chemistry 2】 [In the formula, R １ , R ２ , R ３ , R ４ and R ５ ' has the same meaning as defined in claim 1.

2. The arthropod control composition of claim 1, wherein the compound is

3. The compound may be 2,6-dimethoxy-4-[prop-1-enyl]phenol, 4-allyl-2,6-dimethoxyphenol, 1,2,3-trimethoxy-5-[1-propen-1-yl]benzene, 1,2,3-trimethoxy-5-propylbenzene, 1,2,4-trimethoxybenzene, 2,6-dimethoxy-4-propylphenol, 2,6-dimethoxy-4-methylphenol, 3-(3,4,5-trimethoxyphenyl)prop-2-enoic acid, 2-(4-hydroxy-3-methoxyphenyl)acetic acid, methyl 3-(3,4-dimethoxyphenyl)-2-methylpropanoate, (2,3-dimethoxyphenyl)methanol, 2,3,4-trimethoxybenzaldehyde, 3,4,5-trimethoxybenzaldehyde, 2-ethoxy-4-(methoxymethyl)phenol, 2-ethoxy-4-(ethoxymethyl)phenol, 1,2-Dimethoxy-4-prop-1-enylbenzene, 1,2,3-trimethoxy-5-methylbenzene, 2,6-dimethoxy-4-methylphenol, 1-(2,3,4-trimethoxyphenyl)ethanone, 7-methyl-1,5-benzodioxepin-3-one, 1,2-dimethoxy-3-prop-1-enylbenzene, 1,2,3-trimethoxy-5-propylbenzene, 2,3,4-trimethoxybenzonitrile, 3-ethoxy-4-methoxybenzaldehyde, 2,3,4-trimethoxyphenol, 1-(4-hydroxy-3-methoxyphenyl)ethanone, 2-methoxy-4-(4-methylideneoxan-2-yl)phenol, 4-(3,6-dihydro-4-methyl-2H-pyran-2-yl)-2-methoxy-phenol, and mixtures thereof. The arthropod control composition according to claim 1, wherein the compound is selected from the list consisting of:

4. The compound is 6-dimethoxy-4-[prop-1-enyl]phenol, 4-allyl-2,6-dimethoxyphenol, 1,2,3-trimethoxy-5-[1-propen-1-yl]benzene, 1,2,3-trimethoxy-5-propylbenzene, 1,2,4-trimethoxybenzene, 2,6-dimethoxy-4-propylphenol, 2,6-dimethoxy-4-methylphenol, 3-(3,4,5-trimethoxyphenyl)prop-2-enoic acid, 2-(4 4. The arthropod control composition of claim 3, wherein the compound selected from the group consisting of methyl 3-(3,4-dimethoxyphenyl)acetic acid, methyl 3-(3,4-dimethoxyphenyl)-2-methylpropanoate, (2,3-dimethoxyphenyl)methanol, 2,3,4-trimethoxybenzaldehyde, 3,4,5-trimethoxybenzaldehyde, 2-ethoxy-4-(methoxymethyl)phenol, 2-ethoxy-4-(ethoxymethyl)phenol, and mixtures thereof.

5. 5. An arthropod control composition according to any one of claims 1 to 4, wherein the arthropod is an insect, preferably a mosquito.

6. N,N-Diethyl-3-methylbenzamide (DEET), Ethyl Butylacetylaminopropionate (IR3535), Para-menthane-3,8-diol (PMD), 1-(1-methylpropoxycarbonyl)-2-(2-hydroxyethyl)piperidine (Picaridin), Chinese Cedarwood Oil, Texas Cedarwood Oil, Virginia Cedarwood Oil, Cinnamon Bark Oil, Citronella Oil, Cornmint Oil, Fractionated Hydrated Cyclized Cymbopogon winterianus Oil, Decanoic Acid, Hydrated Cyclized Eucalyptus citriodora Oil, Eugenol, Garlic Oil, Geraniol, Geranium Oil, Lavender, Lavandula Hybrida hybrida) oil, lavandin oil, lemon oil, lemongrass oil, neem extract, metofluthrin, a mixture of cis- and trans-p-menthane-3,8-diol, N,N-diethyl-meta-toluamide, nonanoic acid, rosemary oil, thyme oil, wintergreen oil, 2,3,4,5-bis(butyl-2-ene)tetrahydrofurfural (MGK Repellent 11), cineole, cinnamaldehyde, citronellal, citronellol, coumarin, dibutyl phthalate, diethyl phthalate, dimethyl anthranilate, dimethyl phthalate, ethyl vanillin, eucalyptus oil, δ-octalactone, δ-nonalactone, δ-decalactone, δ-undecalactone, δ-dodecalactone, γ-octalactone, γ-nonalactone, γ-decalactone, γ-undecalactone, γ-dodecalactone, hydroxycitronellal, lime oil, limonene, linalool, methyl anthranilate Chil, mint oil, myrcene, neem oil, sabinene, β-caryophyllene, (1H-indol-2-yl)acetic acid, anethole, anise oil, basil oil, bay oil, camphor, ethyl salicylate, evergreen vegetable oil (pine oil), (1,3,4,5,6,7-hexahydro-1,3-dioxo-2H-isoindol-2-yl)methyl 2,2-dimethyl-3-(2-methylprop-1-enyl)cyclopropanecarboxylate (d-tetramethrin), 3-allyl-2-methyl-4-oxocyclopent-2-enyl-2,2-dimethyl-3-(2-methylprop-1-enyl)-cyclopropanecarboxylate (d-allethrin), α-cyano-3-phenoxybenzyl, 3-(2,2-dichlorovinyl)-2,2-dimethylcyclopropanecarboxylate (cypermethrin), 2-methyl-4-oxo-3-(prop-2-ynyl)cyclopent-2-en-1-yl 2,2-dimethyl-3-(2-methylprop-1-enyl)cyclopropanecarboxylate (prallethrin), acetamiprid, azadirachtin, bendiocarb, bifenthrin, boric acid, chlorpyrifos, deltamethrin, diazinon, dichlorvos, eugenol, fipronil, imidacloprid, linalool, malathion, maltodextrin, metofluthrin , Nicotine, Permethrin, Pyrethrins, Pyrethroids, Rotenone, Silicon Dioxide (Diatomaceous Earth), S-Methoprene, Spinosad (Spinosyn A), Spinosyn D, Tetramethrin, Transfluthrin, 1-(2,6,6-Trimethylcyclohex-2-en-1-yl)but-2-en-1-one, 3-Butylidene-2-benzofuran-1-one, 4-Ethenyl-2-Methoxyphenol, Konjac Green Oil, Labdanum Extract (Cistus spp.), 5-Pentyloxolan-2-one, Chromen-2-one, 3,7-Dimethylocta-2,6-dienal, 4-Hydroxy-3-Methoxybenzaldehyde, 2-Methyl-5-prop-1-en-2-ylcyclohex-2-en-1-one, Mentha spicata (Mentha spicata oil, 6-hexyloxan-2-one, 5-methyl-2-propan-2-ylcyclohexyl acetate, Nigella damascena oil, 2-phenylethanol, 6-pentyloxan-2-one, (4-methoxyphenyl)methyl acetate, Syzygium aromaticum oil, 3,4,4a,5,6,7,8,8a-octahydrochromen-2-one, 3,7,The arthropod control composition of any one of claims 1 to 4, further comprising an arthropod control co-ingredient selected from the group consisting of 7-trimethylbicyclo[4.1.0]hept-3-ene, 2-phenylethyl 2-methylpropanoate, methyl 2-(3-oxo-2-pent-2-enylcyclopentyl)acetate, 4-(2-methoxypropan-2-yl)-1-methylcyclohexene, Mentha piperita oil, 2-methoxy-4-[prop-1-enyl]phenol, 2-methyl-3-(4-propan-2-ylphenyl)propanal, (4-methoxyphenyl)methanol, and mixtures thereof.

7. 10. A method for controlling arthropods, preferably insects, comprising directly contacting or contacting insects with the vapor of a composition according to any one of claims 1 to 4.

8. 5. Use of a composition according to any one of claims 1 to 4 for controlling arthropods, preferably insects.

9. An arthropod control article, preferably an insect control article, comprising an arthropod control composition, preferably an insect control composition, according to any one of claims 1 to 4.

10. 10. The arthropod control article of claim 9, which is a consumer product.

11. Fabric care products such as liquid or solid detergents, fabric softeners, liquid or solid fragrance boosters, fabric refreshers, ironing water, paper, bleach, carpet cleaners, curtain care products, etc.; body care products such as hair care products (e.g. shampoos, colour preparations or hair sprays, colour care products, hair styling products), dental care products, disinfectants, intimate care products, etc.; cosmetics (e.g. skin creams or lotions, vanishing creams, or deodorants or antiperspirants (e.g. sprays or roll-ons), hair removers, tanning or sunscreen or after-sun products, nail products, skin cleansers, make-up products); skin care products (e.g. soaps, shower or bath mousses, oils or gels, or hygiene products, or foot / hand care products).

10. The arthropod control article of claim 9, which is an arthropod control product; an air care product such as an air freshener or a "ready to use" powder air freshener that can be used in domestic spaces (rooms, refrigerators, cupboards, shoes or cars) and / or public spaces (hall, hotel, mall, etc.); or a home care product such as a mold remover, furniture care product, wipes, dish detergent or hard surface (e.g. floor, bathroom, toilet or window cleaner) cleaner; a leather care product; a car care product such as a polish, wax or plastic cleaner; a candle; a spray; a coil, an electric diffuser, a piezo diffuser, a liquid electric diffuser, a diffuser, a rubber septum, a wristband, a patch, a collar, an ear tag, clothing, fabric, paper, biochar, cardboard, a cellulose pad, a mosquito net, a screen door, a curtain, varnish or paint.

12. 10. The arthropod control article of claim 9, which is an air care product, preferably an electric diffuser.

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