Method for sequencing L-polynucleotides
JP2025510104A5Pending Publication Date: 2026-04-14デクソーム カンパニー リミテッド
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Patent Information
- Authority / Receiving Office
- JP · JP
- Patent Type
- Applications
- Current Assignee / Owner
- Filing Date
- 2023-03-21
- Publication Date
- 2026-04-14
AI Technical Summary
Technical Problem
The development of mirror-image biomolecules faces severe barriers due to the lack of efficient and reliable techniques for sequencing L-polynucleotides.
Method used
A novel method for sequencing L-polynucleotides is provided, utilizing mirror nucleotides with cleavable protecting groups and labels, and a mirror image nucleic acid polymerase composed of D-amino acids, enabling high-throughput sequencing.
Benefits of technology
Enables efficient sequencing of L-polynucleotides, overcoming the barriers of existing sequencing technologies and facilitating the development of mirror-image biomolecules.
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Smart Images
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Abstract
The present disclosure provides a novel method for amplifying and sequencing L-polynucleotides. Also provided are L-nucleotides and D-enzymes that can be used in the method. Methods for producing L-nucleotides and D-enzymes are also provided. The development of mirror-image biomolecules and systems faces a severe barrier due to the lack of efficient and reliable techniques for sequencing L-polynucleotides. The present disclosure provides a means to solve this problem.
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