Cleaning Composition

Abstract

The present invention relates to cleaning compositions comprising low levels of hydrogen peroxide and at least one acid selected from the group consisting of salicylic acid, furoic acid, and formic acid.The compositions and methods of the present invention are particularly suitable for use in household cleaning, such as cleaning hard surfaces or cleaning soft surfaces, such as fabrics and laundry.

Description

[Technical field]

[0001] The present invention relates to cleaning compositions comprising low levels of hydrogen peroxide and at least one acid selected from the group consisting of salicylic acid, furoic acid, and formic acid.The compositions and methods of the present invention are particularly suitable for use in household cleaning, such as cleaning hard surfaces or cleaning soft surfaces, such as fabrics and laundry. [Background technology]

[0002] Numerous compositions have been described in the art for use in cleaning hard and soft surfaces. Summary of the Invention [Problem to be solved by the invention]

[0003] While such compositions may provide suitable cleaning performance, there is a need for alternative cleaning compositions for cleaning and / or disinfecting hard surfaces, such as kitchen and bathroom surfaces, and soft surfaces, such as fabrics, such as laundry.

[0004] In particular, it would be beneficial to provide an efficient and cost-effective composition for reducing and / or eliminating microorganisms on soft and hard surfaces that does not rely on overly harsh chemicals and may be safer for consumers. There is also a need for compositions that are more environmentally friendly and avoid the need for complex activators, such as TAED. [Means for solving the problem]

[0005] The present inventors have developed an aqueous cleaning composition with desirable cleaning properties that can be used to clean hard or soft surfaces.

[0006] In a first aspect, there is provided an aqueous cleaning composition comprising: (a) hydrogen peroxide; (b) at least one acid selected from the group consisting of salicylic acid, furoic acid, and formic acid; (c) an anionic surfactant; and (d) at least 90% by weight water. The aqueous cleaning composition may be a hard surface cleanser and / or a soft surface cleanser. In certain embodiments, the aqueous cleaning composition is an aqueous hard surface cleanser composition. In certain embodiments, the aqueous cleaning composition is an aqueous soft surface cleanser composition.

[0007] More specifically, the aqueous cleaning composition comprises or consists essentially of: (a) from about 0.05% to about 4% by weight of hydrogen peroxide; (b) from about 0.01% to about 0.25% by weight of at least one acid selected from the group consisting of salicylic acid, furoic acid, and formic acid; (c) from about 0.05% to about 2.00% by weight of an anionic surfactant; and (d) about 90% or more by weight of water, and the composition has a pH of 2.8 to 3.5.

[0008] The compositions of the present invention are aqueous compositions comprising at least 90% by weight of water. More specifically, the compositions may comprise at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, or at least 99% by weight of water.

[0009] A test suspension (1–5 × 10 per ml) of either Candida albicans or Klebsiella pneumoniae 8 cfu) to the compositions of the invention results in at least a log 2.5 reduction in the number of colony forming units within 60 seconds, preferably at least a log 3 reduction within 60 seconds, more preferably at least a log 4 reduction, and most preferably at least a log 5 reduction.

[0010] The compositions of the present invention are shelf stable for a commercially reasonable period of time, more specifically, the compositions of the present invention are shelf stable for at least 3 months after preparation, specifically, at least 6 months after preparation, more specifically, at least 12 months after preparation, and even more specifically, at least 24 months after preparation.

[0011] The storage stability of the composition of the present invention can be determined by using direct or indirect measures.Direct measures of storage stability include physical stability measures, such as precipitation, and / or chemical stability measures, such as chemical decomposition of one or more components.Indirect measures of storage stability include microbicidal measures, such as bactericidal assays, fungicidal assays, and virus inactivation or virucidal assays.

[0012] As used herein, the term "storage stable" means that the aqueous mixture components do not precipitate (physical stability) or chemically decompose (chemical stability) over a period of time.

[0013] The compositions of the present invention may further comprise (e) a means for adjusting or maintaining the pH of the composition, hi certain embodiments, the compositions of the present invention comprise a means for adjusting or maintaining the pH of the composition within the range of 2.8 to 3.5.

[0014] In some embodiments, the compositions of the present invention consist essentially of: (a) from about 0.05% to about 4% by weight of hydrogen peroxide; (b) from about 0.01% to about 0.25% by weight of at least one acid selected from the group consisting of salicylic acid, furoic acid, and formic acid; (c) from about 0.05% to about 2.00% by weight of an anionic surfactant; (d) at least about 90% by weight of water; and (e) a means for adjusting or maintaining the pH of the composition, wherein the composition has a pH of 2.8 to 3.5.

[0015] The composition may comprise from about 0.01% to about 0.09% by weight of the means for adjusting or maintaining the pH of the composition. The means for adjusting or maintaining the pH of the composition may be an acid or a buffer. The composition may comprise from about 0.01% to about 0.09% by weight of a buffer. The composition may comprise from about 0.02% to about 0.08% by weight of the means for adjusting or maintaining the pH of the composition. The composition may comprise from about 0.02% to about 0.08% by weight of a buffer. In some embodiments, the means for adjusting or maintaining the pH of the composition is sodium citrate, more specifically a sodium citrate buffer.

[0016] Thus, in another embodiment, there is provided an aqueous cleansing composition consisting essentially of about 0.05% to about 4% by weight hydrogen peroxide, about 0.01% to about 0.25% by weight of an acid selected from the group consisting of salicylic acid, furoic acid, and formic acid, about 0.05% to about 2.00% by weight of an anionic surfactant, about 90% or more by weight water, and about 0.01% to about 0.08% by weight of a buffer solution, specifically a sodium citrate buffer solution, the composition having a pH of 2.8 to 3.5.

[0017] The compositions of the present invention may further comprise a sensory component. In certain embodiments, the sensory component is a flavoring agent, a coloring agent, and / or a bittering agent.

[0018] In a further embodiment, there is provided a storage stable aqueous cleansing composition consisting essentially of about 0.05% to about 4% by weight hydrogen peroxide, about 0.01% to about 0.25% by weight of an acid selected from the group consisting of salicylic acid, furoic acid, and formic acid, about 0.05% to about 2.00% by weight of an anionic surfactant, about 90% or more by weight water, and about 0.01% to about 0.08% by weight of a buffer solution, specifically a sodium citrate buffer solution, the composition having a pH of 2.8 to 3.5, and further comprising about 0.01% to about 0.5% by weight of a sensory ingredient.

[0019] In some embodiments, the anionic surfactant is a sodium alkyl sulfate, hi certain embodiments, the anionic surfactant is a sodium alkyl sulfate selected from the group consisting of sodium lauryl sulfate, sodium lauryl sulfonate, and sodium laureth sulfate.

[0020] Accordingly, there is also provided a storage stable aqueous cleansing composition consisting essentially of about 0.05% to about 4% by weight hydrogen peroxide, about 0.01% to about 0.25% by weight of at least one acid selected from the group consisting of salicylic acid, furoic acid, and formic acid, about 0.05% to about 2.00% by weight of an anionic surfactant selected from the group consisting of sodium lauryl sulfate, sodium lauryl sulfonate, and sodium laureth sulfate, about 90% or more by weight water, and about 0.01% to about 0.08% by weight of a buffer solution, specifically a sodium citrate buffer solution, the composition having a pH of 2.8 to 3.5, and further comprising about 0.01% to about 0.5% by weight of a sensory component.

[0021] In some embodiments, the compositions of the present invention comprise from about 0.1% to about 2% hydrogen peroxide by weight, specifically from about 0.25% to 1% hydrogen peroxide by weight.

[0022] Preferably, the acid is salicylic acid, hi some embodiments, the compositions of the present invention comprise about 0.01% to 0.25% by weight of salicylic acid, specifically about 0.1% to 0.2% by weight of salicylic acid.

[0023] In some embodiments, the compositions of the present invention comprise from about 0.25% to about 1% by weight of an anionic surfactant, in some embodiments, the compositions of the present invention comprise from about 0.25% to about 1.00% by weight of an anionic surfactant selected from the group consisting of sodium lauryl sulfate, sodium lauryl sulfonate, and sodium laureth sulfate.

[0024] The compositions of the present invention are ready to use and do not require dilution or reconstitution. The compositions can be applied to a surface by pouring, spraying, and / or wiping. The compositions are foamable and may be applied to a surface in the form of an aerated foam. The compositions of the present invention are substantially free of persalt salts. The compositions of the present invention are free of TAED.

[0025] In some embodiments, the aqueous composition is a hard surface cleanser composition. In some embodiments, the aqueous composition is a soft surface cleanser composition for use in cleaning fabrics, such as laundry. In certain embodiments, the aqueous composition is a laundry detergent booster composition and / or a stain treatment composition.

[0026] In a second aspect of the present invention, a container is provided that contains the composition of the first aspect. Specifically, the container is a dispenser. Specifically, the dispenser comprises or essentially consists of a container that defines a reservoir and an applicator head in fluid communication with the reservoir, where the reservoir contains the composition of the present invention, and the applicator head is configured to dispense the composition from the reservoir, specifically in the form of a spray and / or foam.

[0027] As non-limiting examples, the container comprises high density polyethylene (HDPE) and / or polyethylene terephthalate (PET). In some embodiments, the container comprises high density polyethylene (HDPE) and polyethylene terephthalate (PET). In some embodiments, the container is a high density polyethylene (HDPE) container. In some embodiments, the container is a polyethylene terephthalate (PET) container.

[0028] In a third aspect of the present invention, there is provided a disposable moistened pad for cleaning hard surfaces, comprising (i) a substrate and (ii) the cleansing composition of the first aspect, the substrate being impregnated with the composition.

[0029] In a fourth aspect of the present invention there is provided a hard surface cleansing composition according to the first aspect for use in a method of cleaning a hard surface.

[0030] In some embodiments of the fourth aspect, the hard surface cleansing composition may be provided in a container according to the second aspect. In these embodiments, the hard surface cleansing composition may be applied to the hard surface by spraying or pouring.

[0031] In some embodiments of the fourth aspect, the hard surface cleansing composition may be provided in the form of a substrate impregnated with the cleansing composition according to the third aspect. In these embodiments, the hard surface cleansing composition may be applied to the hard surface by wiping.

[0032] In a fifth aspect of the present invention there is provided a cleansing composition according to the first aspect for use in a method of cleaning a soft surface. The cleansing composition may thus be a stain removal composition and / or a laundry detergent booster composition.

[0033] In a sixth aspect of the invention there is also provided a method of cleaning a hard or soft surface comprising maintaining a cleansing composition according to the first aspect in contact with the hard or soft surface for a period of time.

[0034] There is also provided a cleanser composition according to the first aspect for use in a method of killing microorganisms, such as Candida albicans, on a hard or soft surface. Specifically, the method comprises contacting the microorganisms on the hard or soft surface with the cleansing composition for a period of time sufficient to kill the microorganisms.

[0035] In particular, the microorganism is a bacterium, a fungus, or a virus. In some embodiments, the microorganism is a Bacterium, in particular a Gram-negative bacterium, such as Klebsiella pneumoniae. In some embodiments, the microorganism is a fungus, in particular a yeast, such as Candida albicans. In some embodiments, the microorganism is a virus, for example an enveloped or non-enveloped virus, such as an influenza virus or a coronavirus. In certain embodiments, the virus is an influenza virus H1N1. In certain embodiments, the virus is a coronavirus, such as SARS-CoV, SARS-CoV-1, or SARS-CoV-2.

[0036] The compositions and methods described herein are particularly useful for treating hard surfaces, such as floors, kitchen surfaces, bathroom surfaces and walls.

[0037] The compositions and methods described herein are particularly useful for treating soft surfaces, such as fabrics and laundry, for example as additives to laundry wash liquors. [Brief description of the drawings]

[0038] [Figure 1] FIG. 1 shows a ceramic tile stained with tea comparing an untreated area (UT) with an area treated with a composition of the present invention (T). DETAILED DESCRIPTION OF THE PREFERRED EMBODIMENTS

[0039] The present invention is directed to aqueous cleansing compositions comprising either salicylic acid, furoic acid, or formic acid in combination with hydrogen peroxide and an anionic surfactant.

[0040] Surprisingly, the inventors have found that such compositions exhibit excellent antimicrobial efficacy. Without wishing to be bound by theory, there appears to be a synergistic antimicrobial effect when microorganisms are exposed to a combination of hydrogen peroxide and an acid component (salicylic acid, formic acid, or furoic acid), and even low levels of hydrogen peroxide achieve a reduction in the number of colony-forming units of log 2.5 or even greater within 60 seconds (in a killing assay). It is noted that other acids, such as phosphoric acid or citric acid, do not exhibit such synergistic antimicrobial efficacy, and the effect is not related to, for example, pKa.

[0041] Advantageously, such compositions have excellent skin tolerability, making them particularly suitable for use in cleaning surfaces where the product is likely to come into contact with the skin of the hands, fingers, or feet.

[0042] References to "cleaning" and "cleansing" generally refer to the treatment of a surface to reduce or remove unwanted materials such as dirt, oil, stains, or microorganisms. The term "hard surfaces" refers to solid, substantially inflexible surfaces such as countertops, tiles, floors, walls, sanitary ware, kitchen and bathroom furniture, etc. The term "soft surfaces" refers to softer, highly flexible materials such as woven and nonwoven fabrics, such as clothing, textiles, and carpets.

[0043] The composition is effective for cleaning hard surfaces and removing stains (Figure 1). The composition is highly compatible with surfaces and therefore will not corrode or discolor plastics, such as acrylics, nylon, porcelain, resins, metals, or other materials often found in residential and commercial environments.

[0044] The composition is also effective for cleaning soft surfaces and removing stains.The composition may be used as a laundry additive for use in cleaning fabrics, for example, to pretreat stains or to add to laundry detergent in the wash liquor to improve (boost) or add detergent effectiveness.When used as a laundry booster, the composition of the present invention provides cleaning or disinfecting effects.These effects may be particularly advantageous when cleaning baby wear and diapers.

[0045] The compositions have a desirable environmental profile, decomposing primarily into oxygen and water. More specifically, the compositions of the present invention are free of persalts (e.g., sodium perborate) and commonly used activators (e.g., TAED, NOBS, and LOBS), which are expensive and may have environmental impacts. Avoiding activators such as TAED means that the compositions of the present invention have an improved safety profile.

[0046] For the avoidance of doubt, references to "wt %" mean that the amount of each component is by weight of the entire composition, selected such that all components in the composition add up to 100 weight percent. In the case of the compositions of the present invention, the balance or remainder is water. The term "aqueous solution" refers to a solution in which the solvent is water and the other components of the composition are dispersed, mixed, and / or dissolved in the composition. Specifically, the composition comprises at least 80 wt % water, such as at least 85 wt % or 90 wt % water. More specifically, the composition may comprise at least 91 wt %, at least 92 wt %, at least 93 wt %, at least 94 wt %, at least 95 wt %, at least 96 wt %, at least 97 wt %, at least 98 wt %, or at least 99 wt % water. Thus, the composition may comprise 80 wt % to 99 wt % water, such as 85 wt % to 99 wt %, 90 wt % to 99 wt %, or 95 wt % to 99 wt % water. Specifically, water is the only solvent and no organic solvent, such as alcohol, is used.

[0047] The composition of the present invention contains hydrogen peroxide, also referred to as H2O2 (CAS number: 7722-84-)1. Specifically, the composition of the present invention contains about 0.05% by weight to about 4% by weight of hydrogen peroxide, for example, about 0.05% by weight to about 4% by weight, about 0.1% by weight to about 4% by weight, or about 0.25% by weight to about 4% by weight of hydrogen peroxide. More specifically, the composition of the present invention contains about 0.05% by weight to about 2% by weight, about 0.1% by weight to about 2% by weight, or about 0.25% by weight to about 2% by weight of hydrogen peroxide. Even more specifically, the composition of the present invention contains about 0.05% by weight to about 1% by weight, about 0.1% by weight to about 1% by weight, or about 0.25% by weight to about 1% by weight of hydrogen peroxide. Even more specifically, the composition contains from about 0.1% to about 0.75% by weight, or from about 0.25% to about 0.75% by weight, for example, about 0.25% by weight, about 0.3% by weight, about 0.4% by weight, about 0.5% by weight, about 0.6% by weight, about 0.7% by weight, or about 0.75% by weight of hydrogen peroxide.

[0048] The composition of the present invention further comprises at least one acid selected from the group consisting of salicylic acid, furoic acid, and formic acid. Salicylic acid (CAS number: 69-72-7) may also be referred to as 2-hydroxybenzoic acid. Formic acid (CAS number: 64-18-6) may also be referred to as methanoic acid. Furoic acid refers to 2-furoic acid (CAS number: 88-14-2), also known as furan-2-carboxylic acid, and / or 3-furoic acid (CAS number: 488-93-7), also known as furan-3-carboxylic acid.

[0049] The composition may include 2-furoic acid and / or 3-furoic acid. In some embodiments, the acid is 2-furoic acid. In other embodiments, the acid is 3-furoic acid.

[0050] In a preferred embodiment of the invention, the acid is salicylic acid.

[0051] Although it is preferred to use one acid selected from the group consisting of salicylic acid, furoic acid, and formic acid, those skilled in the art will understand that combinations of these acids may also be used. For example, the composition of the present invention further comprises at least two acids selected from the group consisting of salicylic acid, furoic acid, and formic acid, such as two of these acids, or three of these acids. Thus, in certain embodiments, the composition may comprise a combination of salicylic acid, furoic acid, and formic acid, for example, in any suitable molar ratio, for example, 1:1:1 to 2:1:1, 1:2:1, or 1:1:2. In other embodiments, the composition may comprise a combination of salicylic acid and furoic acid, a combination of salicylic acid and formic acid, or a combination of furoic acid and formic acid, for example, in any suitable molar ratio, for example, 1:1 to 3:1, 1:1 to 1:1, for example, 1:1, 1:2, 1:3, 3:1, or 2:1.

[0052] The compositions of the present invention may comprise from about 0.01% to about 0.25% by weight of acid, from about 0.1% to about 0.25% by weight of acid, or from about 0.15% to about 0.2% by weight of acid, for example, about 0.15%, 0.16%, 0.17%, 0.18%, 0.19%, or about 0.2% by weight of acid.

[0053] The composition of the present invention comprises a surfactant, more specifically an anionic surfactant. Suitable anionic surfactants are known in the art. Specifically, the anionic surfactant is a sodium alkyl sulfate, such as a sodium sulfate having an alkyl group having 8 to 20 carbon atoms. Non-limiting examples of these include sodium decyl sulfate, sodium lauryl sulfate (also referred to as SLS or sodium dodecyl sulfate (SDS)), sodium tetradecyl sulfate, sodium hexadecyl sulfate, and sodium octadecyl sulfate. In a particular embodiment, the anionic surfactant is a sodium alkyl sulfate selected from the group consisting of sodium lauryl sulfate, sodium lauryl sulfonate, and sodium laureth sulfate. Specifically, the anionic surfactant is sodium lauryl sulfate.

[0054] The composition may comprise from about 0.05% to about 2.00% by weight of anionic surfactant, specifically from about 0.1% to about 2% by weight, more specifically from about 0.25% to about 1% by weight, or even more specifically from about 0.3% to about 0.8% by weight of anionic surfactant, such as about 0.3%, 0.4%, 0.5%, 0.6%, 0.7%, or about 0.8% by weight of anionic surfactant.

[0055] The compositions of the present invention preferably have a pH in the range of 2.8 to 3.5, for example a pH in the range of 2.8 to 3.2, for example a pH of about 3.0 or about 3.1. To achieve this, the compositions of the present invention may comprise a means for adjusting or maintaining the pH of the composition within this range. The compositions may comprise from about 0.01% to about 0.09% by weight, for example from about 0.02% to 0.08% by weight of the means for adjusting or maintaining the pH of the composition. The compositions may comprise from about 0.02%, 0.03%, 0.04%, 0.05%, 0.06%, 0.07% or about 0.08% by weight of the means for adjusting or maintaining the pH of the composition.

[0056] The means for adjusting or maintaining the pH of the composition may be an acid or a pH buffer (also referred to as a buffer). Specifically, the means for adjusting or maintaining the pH of the composition is a pH buffer. More specifically, the means for adjusting or maintaining the pH of the composition is a pH buffer containing sodium citrate. Even more specifically, the means for adjusting or maintaining the pH of the composition is a sodium citrate buffer. Sodium citrate buffers are known in the art and can be prepared and adjusted to a desired pH by, for example, mixing citric acid (monohydrate) and trisodium citrate (dehydrate) in a ratio of 82:18 to 73:27, respectively, as a non-limiting example.

[0057] Specifically, the compositions of the present invention exhibit a skin tolerability score of at least 10% mean cell viability, at least 11%, at least 12%, at least 13%, at least 14%, or at least 15% mean cell viability as measured by an in vitro skin tolerability assay, more specifically as measured by the in vitro EPIDERM Skin Irritation Test (EPI-200-SIT, MatTek Corporation).

[0058] Preferably, the composition of the present invention is alcohol-free. The term "alcohol-free" refers to the absence of alcohol (0% by weight). For the avoidance of doubt, this term may include the presence of alcohol, but in amounts below the detection limit of the analytical method and in amounts that are too low to be detected or accurately measured.

[0059] Alternatively, if sensory ingredients are included, the compositions of the present invention may be substantially alcohol-free, as some sensory ingredients (described below) include alcohol. As used herein, "substantially alcohol-free" means that the composition contains less than 0.5% alcohol, such as 0.4% or less, 0.3% or less, 0.25% or less, 0.2% or less, 0.1% or less, 0.05% or less, or less than 0.01% alcohol.

[0060] The composition of the present invention is a foaming formulation. "Foaming formulation" refers to a composition that can form foam, specifically foam with small bubble size that gives the appearance of thick and rich foam. The foam can be easily brushed over the entire surface.

[0061] The compositions of the present invention form stable foams with desirable physicochemical properties, such as volume, density, and spreadability, that do not change significantly over a period of time, and thus the foam does not break down immediately during use. More specifically, the foams formed by the compositions of the present invention do not "break down quickly" and are stable when dispensed from a container, for example by spraying, and do not break down immediately on contact with a surface. The foams formed by the compositions of the present invention do not break down quickly, but are "fragile", in other words, can be easily spread across a surface by applying a weak shear force. The foam characteristics can be measured using tests known in the art, for example, by performing foam formation (foam height vs. time) and foam collapse experiments. Preferably, the foam maintains its structure and thus remains in contact with the surface for a time sufficient to clean and / or kill microorganisms. Specifically, the use time is 3 minutes or less, more specifically 2 minutes or less, and even more specifically 60 seconds or less, for example about 30 to 60 seconds.

[0062] The composition of the present invention can be foamed in the absence of a propellant. Specifically, the composition of the present invention is dispensed from a container without the use of a propellant. Specifically, the composition can be foamed by agitation, such as shaking or stirring, or by manual aeration (e.g., passing atmospheric air through the formulation, such as by manually operating a dispensing head, to generate foam). Specifically, the composition of the present invention can be dispensed from a container with a suitable dispensing head, such as a foam applicator head. The foam may be applied directly to the surface, optionally by brushing or wiping. After cleaning, the surface may be optionally rinsed with water or wiped dry, for example to remove any pools or droplets of the composition.

[0063] For compositions used to clean surfaces, it may be desirable to include at least one sensory ingredient. "Sensory ingredient" refers to an ingredient that can be used to impart fragrance, color, or taste to the composition. Other than imparting desirable organoleptic properties to the composition, sensory ingredients are generally not active ingredients, in other words, sensory ingredients generally do not play an active role in cleaning or killing bacteria.Specifically, sensory ingredients are at least one fragrance or flavor, colorant, or bittering agent.

[0064] Suitable fragrances, also referred to as perfumes, include ingredients that provide olfactory benefits, for example masking any chemical odors associated with the product.Fragrances can improve the odor of the composition itself and / or can impart odor on surfaces treated with the composition of the present invention.Fragrance ingredients are easily solubilized in the composition of the present invention, for example by detergent ingredients.Suitable fragrance ingredients and compositions are known in the art and can be selected based on the desired scent and compatibility with the ingredients of the composition, for example hydrogen peroxide and acid.

[0065] "Colorant," also referred to as "colorant," means any type of color-imparting compound, such as a dye, pigment, or other material. Specifically, any colorant is stable and not decomposed by components of the composition, such as hydrogen peroxide, an acid component, or the pH of the composition.

[0066] The term "bittering agent" as used herein refers to a compound used to impart an undesirable bitter taste or flavor to discourage animals, such as pets, e.g., dogs and cats, or humans, e.g., children and infants, from ingesting (swallowing) the composition. Sensory ingredients are known in the art and may be natural or artificial (synthetic).

[0067] The compositions of the present invention may comprise from about 0.01% to about 0.5% by weight of the sensory ingredient, specifically from about 0.1% to about 0.3% by weight of the sensory ingredient, more specifically from about 0.2% to about 0.3% by weight of the sensory ingredient, for example about 0.1%, 0.15%, 0.2%, 0.25%, 0.3%, 0.35%, 0.4%, 0.45%, or about 0.5% by weight of the sensory ingredient.

[0068] The sensory ingredients must be compatible with the components of the composition and must not be altered or decomposed, for example, upon contact with hydrogen peroxide or acid. More specifically, any flavors, colors, and bittering agents used are peroxide-stable (i.e., stable in the presence of peroxide), acid-stable (i.e., stable in the presence of salicylic acid, furoic acid, and formic acid), and pH-stable at a pH of 2.8 to 3.5.

[0069] Typically, the compositions of the present invention are stable at room temperature of 20° C. for at least 3 months, particularly at least 6 months at room temperature of 20° C., more particularly at least 12 months at room temperature of 20° C., and even more particularly at least 24 months at room temperature of 20° C.

[0070] As used herein, the term "stability" or "storage stability" refers to the ability of a composition to maintain particular physical or chemical properties, such as antimicrobial efficacy, during storage at a particular temperature for a period of time after manufacture.

[0071] The stability of the compositions of the present invention can be determined by comparing the antimicrobial efficacy before and after a period of storage using a suitable killing or inactivation assay that measures the reduction in the number of viable microorganisms present in a sample after exposure to the composition.

[0072] As used herein, the term "microorganism" refers to bacteria, fungi, such as yeast or mold, and viruses. The compositions of the present invention kill and / or inhibit the growth of bacteria, fungi, and viruses and may be referred to as "antimicrobial agents" or "microbicides." Thus, the compositions of the present invention may be "biocidal" compositions that kill bacteria and / or inhibit the growth of bacteria, and / or "fungicidal" compositions that kill fungi and / or inhibit the growth of fungi, and / or "viricidal" compositions that inactivate virus particles so that they cannot infect host cells. Reference to "cleaning" refers to simultaneous cleaning and disinfection. As used herein, "disinfection" refers to the killing of microorganisms living on a surface.

[0073] As used herein, the term "kill" refers to causing the death of a microorganism. In the context of a population of microorganisms, the term "kill" or "killing" refers to reducing the total amount or level of living or viable microorganisms by causing the death of some or substantially all of the microorganisms in the population. In the context of viruses, killing or killing refers to rendering the virus unable to infect and / or replicate in host cells, for example by inactivation or destruction. Thus, the killing assay can be a bactericidal assay, a fungicidal assay, a virucidal assay, or a viral inactivation assay.

[0074] In some embodiments, the composition is a virucidal composition capable of killing influenza viruses or coronaviruses. In certain embodiments, the virus is influenza virus H1N1. In certain embodiments, the virus is a coronavirus, such as SARS-CoV, SARS-CoV-1, or SARS-CoV-2.

[0075] For the avoidance of doubt, the use of the terms "a" or "an" in relation to microorganisms, e.g., bacteria, fungi, and viruses, is to be read to refer to one or more of the entities, e.g., a population of bacteria growing on a surface, e.g., in the form of a biofilm. The term "biofilm" refers to a film formed of a surface-attached assembly of microorganisms that are entrapped within a self-produced extracellular polymeric matrix. Such biofilms often form in aquatic environments, e.g., on corners and surfaces of sinks, faucets, drains, etc., as non-limiting examples.

[0076] Opportunistic yeasts, such as Candida albicans, can be found throughout the environment, including food, such as citrus fruits, vegetables, and bread. It is one of the few species of Candida that can infect humans and cause candidiasis, resulting from fungal overgrowth. C. albicans is commonly used as a model organism for fungal pathogens. Thus, the efficacy and stability of the compositions of the present invention can be determined by measuring the antimicrobial efficacy against Candida albicans using a suitable killing assay, such as the assay described in the Examples. For example, stability can be determined by comparing the antimicrobial efficacy of the composition before and after a storage period.

[0077] The level of killing can be defined as a proportion, e.g., a percentage, or by reference to the log reduction in the total amount or level of microorganisms. Log reduction is used in the art to refer to, for example, the number of viable microorganisms killed after contacting the microorganisms with a composition of the invention. The terms "log X reduction" and "x log reduction" are used interchangeably and refer to a reduction of 10 x A log 4 reduction refers to a reduction in the number of viable microorganisms. For example, a log 4 reduction means that after contacting a population of microorganisms with a composition, the number of microorganisms remaining in the population is 10,000 times lower, or 1 / 10, than the population before contacting the population with the composition. 4 This means that:

[0078] Specifically, a suspension of Candida albicans (10 per ml) 8Exposure of Candida albicans suspensions (10 cfu per ml) to the compositions of the invention results in at least a log 2.5 reduction, specifically at least a log 3 reduction, more specifically at least a log 4 reduction, and even more specifically at least a log 5 reduction in the number of Candida albicans colony forming units within 60 seconds of exposure when measured at least 3 months after preparation of the composition. 8 Exposure of Candida albicans suspensions (10 cfu per ml) to the compositions of the invention results in at least a log 2.5 reduction, specifically at least a log 3 reduction, more specifically at least a log 4 reduction, and even more specifically at least a log 5 reduction in the number of Candida albicans colony forming units within 60 seconds of exposure when measured at least 6 months after preparation of the composition. 8 Exposure of Candida albicans suspensions (10 per ml) to the compositions of the invention results in at least a log 2.5 reduction, specifically at least a log 3 reduction, more specifically at least a log 4 reduction, and even more specifically at least a log 5 reduction in the number of Candida albicans colony forming units, within 60 seconds of exposure, when measured at least 12 months after preparation of the composition. 8 cfu) to a composition of the invention results in at least a log 2.5 reduction, specifically at least a log 3 reduction, more specifically at least a log 4 reduction, and even more specifically at least a log 5 reduction in the number of Candida albicans colony forming units within 60 seconds of exposure when measured at least 24 months after preparation of the composition.

[0079] Klebsiella pneumoniae is a gram-negative bacterium that causes multiple healthcare-associated infections. It can often be found in households and healthcare settings, for example on kitchen surfaces and sponges. Therefore, the stability of the compositions of the present invention can also be determined by measuring the antimicrobial efficacy against Klebsiella pneumoniae using a suitable bactericidal assay, for example the assay described in the Examples.

[0080] Specifically, a suspension of Klebsiella pneumoniae (10 per ml) 8 Exposure of a suspension of K. pneumoniae (10 cfu per ml) to a composition of the invention results in at least a log 2.5 reduction, specifically at least a log 3 reduction, more specifically at least a log 4 reduction, and even more specifically at least a log 5 reduction in the number of K. pneumoniae colony forming units within 60 seconds of exposure when measured at least 3 months after preparation of the composition. 8 Exposure of a suspension of K. pneumoniae (10 cfu per ml) to a composition of the invention results in at least a log 2.5 reduction, specifically at least a log 3 reduction, more specifically at least a log 4 reduction, and even more specifically at least a log 5 reduction in the number of K. pneumoniae colony forming units within 60 seconds of exposure when measured at least 6 months after preparation of the composition. 8 Exposure of a suspension of K. pneumoniae (10 per ml) to a composition of the invention results in at least a log 2.5 reduction, specifically at least a log 3 reduction, more specifically at least a log 4 reduction, and even more specifically at least a log 5 reduction in the number of K. pneumoniae colony forming units, within 60 seconds of exposure, when measured at least 12 months after preparation of the composition. 8 cfu) to a composition of the invention results in at least a log 2.5 reduction, specifically at least a log 3 reduction, more specifically at least a log 4 reduction, and even more specifically at least a log 5 reduction in the number of K. pneumoniae colony forming units, within 60 seconds of exposure, when measured at least 24 months after preparation of the composition.

[0081] The compositions of the present invention retain at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, or at least 99% antimicrobial efficacy after at least 3 months, at least 6 months, at least 12 months, or at least 24 months at room temperature (20° C.).

[0082] Also provided is a container comprising the composition of the invention. Also provided is a dispenser comprising (i) a container comprising the composition of the invention and (ii) an applicator head. More specifically, provided is a dispenser consisting essentially of (i) a container comprising the composition of the invention and (ii) an applicator head configured to dispense the composition in the form of a spray and / or foam. Even more specifically, provided is a dispenser comprising or consisting essentially of a container defining a reservoir and an applicator head in fluid communication with the reservoir, wherein the reservoir comprises the composition of the invention and the applicator head is configured to dispense the composition from the reservoir in the form of a spray and / or foam.

[0083] The container can be made of any suitable material. Suitable materials are those that do not decompose, interact with, or react with the components of the composition. Specifically, suitable materials do not interact with, react with, or decompose on contact with hydrogen peroxide, more specifically, 0.05% to 4% by weight of hydrogen peroxide, e.g., on prolonged contact. Specifically, suitable materials do not interact with, react with, or decompose on contact, e.g., on prolonged contact with salicylic acid, furoic acid, or formic acid, more specifically, 0.01% to about 0.25% by weight of salicylic acid, furoic acid, or formic acid. Specifically, suitable materials do not interact with, react with, or decompose on contact, e.g., on prolonged contact with anionic surfactants, more specifically, 0.05% to about 2.00% by weight of anionic surfactants.

[0084] As non-limiting examples, the container may comprise high density polyethylene (HDPE) and / or polyethylene terephthalate (PET). In some embodiments, the container comprises high density polyethylene (HDPE) and polyethylene terephthalate (PET). In some embodiments, the container is a high density polyethylene (HDPE) container. In some embodiments, the container is a polyethylene terephthalate (PET) container.

[0085] After accelerated stability testing of the compositions of the present invention stored in containers made from high density polyethylene (HDPE) or polyethylene terephthalate (PET) and other plastic and metal components, no evidence of corrosion or other damage to the container was observed. Thus, a container containing the composition of the present invention, the container being made from polyethylene terephthalate (PET) or high density polyethylene (HDPE), is also provided. Also provided is a dispenser comprising (i) a container containing the composition of the present invention and (ii) an applicator head, the container being made from polypropylene (PP), more specifically, a dispenser consisting essentially of (i) a polyethylene terephthalate (PET) or high density polyethylene (HDPE) container containing the composition of the present invention and (ii) an applicator head configured to dispense the composition in the form of a spray and / or foam. Even more specifically, the present invention provides a dispenser comprising or consisting essentially of a polyethylene terephthalate (PET) or high density polyethylene (HDPE) container defining a reservoir and an applicator head in fluid communication with the reservoir, wherein the reservoir contains a composition of the present invention and the foaming applicator head is configured to dispense the composition from the reservoir in the form of a spray and / or foam.

[0086] Specifically, the compositions of the present invention do not contain persalt salts, such as sodium percarbonate, sodium perborate, sodium persulfate, potassium persulfate, or ammonium persulfate. The use of the term "persalt salt" refers to any solid inorganic compound that, when dissolved in water under standard temperature and pressure conditions, liberates hydrogen peroxide and an inorganic acid salt. Thus, the compositions of the present invention are free of sodium percarbonate, free of sodium perborate, free of sodium persulfate, free of potassium persulfate, and / or free of ammonium persulfate. Even more specifically, the compositions of the present invention are substantially free of persalt salts. The term "substantially free of persalt salts" refers to the absence (0% by weight) of persalt salts. For the avoidance of doubt, this term may also include the presence of persalt salts, but in amounts below the detection limit of the analytical method and in amounts too low to be detected or accurately measured.

[0087] Specifically, the compositions of the present invention are free of complex peroxyacid bleach precursors such as N,N,N',N'-tetraacetylethylenediamine (TAED), decanoyloxybenzoic acid (DOBA), decanoyloxybenzene sulfonate (DOBS), tetraacetylglycoluril (TAGU), sodium acetoxybenzenesulfonate (SABS), nonanoyloxybenzene sulfonate (NOBS), sodium 4-(isononanoyloxy)benzenesulfonate (iso-NOBS), sodium nonanoyloxybenzenesulfonate (SNOBS) and sodium benzoyloxybenzenesulfonate (SBOBS), sodium 4-(2-decanoyloxyethoxycarbonyloxy)benzenesulfonate (DECOBS), and sodium lauroyloxybenzenesulfonate (LOBS). Thus, the compositions of the present invention are TAED-free, DOBA-free, DOBS-free, SABS-free, NOBS-free, iso-NOBS-free, SNOBS-free, DECOBS-free, and LOBS-free.

[0088] Composition for use in cleaning The present invention is also directed to the above compositions for use in a method of cleaning a surface, such as a hard surface and / or a soft surface.

[0089] These methods involve applying the composition to a surface and leaving the composition in contact with the surface for a period of time.

[0090] The composition may be applied in the form of a spray and / or foam. Thus, the method may include applying the composition to a surface in the form of a spray and / or foam. The method may include dispensing the composition from a container in the form of a spray and / or foam. Specifically, when dispensed, the composition may be activated to a foam via a foam applicator head. The composition may be applied directly to a surface, such as a hard or soft surface, by spraying, and optionally wiping or stirring, such as brushing. In some embodiments, the composition may be applied directly to a surface, such as a hard or soft surface, by pouring, and optionally wiping or stirring, such as brushing.

[0091] In other embodiments, the composition can be applied to a surface, such as a hard or soft surface, using a substrate, such as a sponge, wipe, cloth, brush, etc. In these embodiments, the composition is first distributed onto a substrate, for example by pouring or spraying, and then applied to the surface using the substrate, for example by wiping or brushing. In this way, the composition is transferred from the substrate onto the surface, specifically as a result of physical contact between the substrate and the surface. Similarly, the composition can be applied to a surface using a disposable wet pad that includes a substrate impregnated with the cleansing composition of the present invention. In such an embodiment, the composition is applied to a surface using a disposable wet pad, for example by wiping or brushing, and the composition is transferred from the substrate onto the surface.

[0092] Specifically, the composition is left in contact with the surface for a period of time.

[0093] Specifically, the composition is maintained in contact with the surface for a period of time sufficient to kill at least 80%, e.g., at least 85%, at least 90%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or at least 99.9% of the microorganisms present on the surface.

[0094] Specifically, the microorganism is Candida albicans and / or Klebsiella pneumoniae, more specifically Candida albicans. Specifically, the composition is maintained in contact with the surface for a period of time sufficient to achieve at least a log 2.5 reduction, preferably at least a log 3 reduction, more preferably at least a log 4 reduction, and most preferably at least a log 5 reduction in the number of Candida albicans and / or Klebsiella pneumoniae colony forming units on the surface. Preferably, the period of time is not more than 3 minutes, not more than 3 minutes, not more than 2 minutes, not more than 2 minutes, not more than 60 seconds, not more than 60 seconds, specifically 30 seconds to 60 seconds. After this period of time, the surface may be wiped, for example with a cloth or sponge, or rinsed with water to remove residual composition.

[0095] The compositions of the present invention, for example when sprayed onto a surface, are non-irritating to the mucous membranes or eyes of the user.

[0096] The compositions of the present invention have improved skin tolerability (e.g., compared to certain other cleansers), and are particularly suitable for cleaning surfaces where the composition may come into contact with the skin of the hands or fingers, either accidentally or during manual handling processes. Specifically, the compositions of the present invention have a skin tolerability score of at least 10% average cell viability, at least 11%, at least 12%, at least 13%, at least 14%, or at least 15% average cell viability, as measured by an in vitro skin tolerability assay.

[0097] In certain embodiments, there is provided a composition of the invention for use in a method of cleaning a surface, the method comprising dispensing the composition from a container onto the surface, optionally spreading the composition over the surface, maintaining the composition in contact with the surface for a period of time, specifically 30 to 60 seconds, and optionally wiping and / or rinsing the surface with water to remove residual composition.

[0098] In a particular embodiment, there is provided a composition of the invention for use in a method of cleaning a surface, the method comprising dispensing the composition from a container onto the surface in the form of a spray and / or foam, optionally spreading the composition over the surface, maintaining the composition in contact with the surface for a period of time, specifically 30 to 60 seconds, and optionally wiping and / or rinsing the surface with water to remove residual composition.

[0099] In certain embodiments, there is provided a composition of the invention for use in a method of cleaning a surface, the method comprising dispensing the composition from a container onto a substrate, applying the composition to the surface using the substrate, maintaining the composition in contact with the surface for a period of time, specifically 30-60 seconds, and optionally wiping and / or rinsing the surface with water to remove residual composition.

[0100] Composition for use in laundry The compositions of the present invention may be used to clean soft surfaces, such as fabrics, typically before or during the wash cycle.

[0101] The composition can help remove soil and stains from fabrics. For example, the composition can decolorize the soil / stains either in solution or on textile fibers by bleaching and / or chemical decomposition. The composition can also break the bond between the soil / stains and fabrics, reducing adhesion, thereby making the soil and stains easier to remove or disperse during subsequent wash cycles. The composition of the present invention also provides a cleaning or disinfecting effect.

[0102] Thus, in some embodiments, the compositions of the present invention may be used to pre-treat fabrics, such as clothing, in which the composition is applied directly to the fabric and allowed to remain in contact with the fabric for a period of time prior to washing and / or rinsing the fabric in a subsequent wash cycle.

[0103] In some embodiments, the compositions of the present invention may be used to pre-treat stains on fabrics, such as clothing, In these embodiments, the composition is applied directly to the stain and allowed to remain in contact with the stain for a period of time prior to washing and / or rinsing the fabric in a subsequent wash cycle.

[0104] In some embodiments, the composition of the present invention can be used as a laundry booster. The term "laundry booster" refers to an additive used as a complement to laundry detergent during the pre-wash, wash and / or rinse cycles of the laundry process. As an addition to laundry detergent in the wash liquor, the composition of the present invention can improve, complement or add to the detergent's effectiveness. When used as a laundry booster, the composition of the present invention provides cleaning or disinfecting benefits. These benefits can be particularly advantageous when washing baby wear and diapers.

[0105] In some embodiments, the composition is used as a laundry booster to complement a laundry detergent during the wash cycle only, while in other embodiments, the composition is used as a laundry booster during the rinse cycle only.

[0106] Accordingly, there is provided (i) a composition for use as a laundry booster in a method comprising forming a wash liquor comprising the composition of the present invention, a laundry detergent composition, and water, contacting fabrics with the wash liquor, and subjecting the fabrics to a laundry wash cycle in the wash liquor.

[0107] The washing process may be a manual process, for example hand washing, or it may be an automatic process using a washing machine.

[0108] Compositions for use in killing microorganisms - Patents.com Also provided are compositions of the invention for use in a method for killing microorganisms, such as Candida albicans, on a surface. In some embodiments, compositions of the invention for use in a method for killing bacteria, such as Klebsiella pneumoniae, on a surface. In some embodiments, compositions of the invention for use in a method for killing fungi, such as yeast, such as Candida albicans, on a surface. In some embodiments, compositions of the invention for use in a method for inactivating, e.g., killing, viruses on a surface.

[0109] These methods include applying a composition of the present invention to a surface containing at least one microorganism and maintaining the composition in contact with the surface for a period of time sufficient to kill the at least one microorganism. One of skill in the art will recognize that when applying a composition to a surface containing microorganisms, the composition also contacts the microorganisms on the surface.

[0110] Specifically, the composition is maintained in contact with the surface for a period of time sufficient to kill at least 80%, e.g., at least 85%, at least 90%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or at least 99.9% of the microorganisms present on the surface.

[0111] Thus, the method may include applying a composition of the present invention to a surface containing a microbial population and maintaining the composition in contact with the surface for a period of time sufficient to kill at least 80% of the microbial population.

[0112] In particular, the microorganism is Candida albicans and / or Klebsiella pneumoniae, more particularly Candida albicans.

[0113] Specifically, the composition is maintained in contact with the surface for a period of time sufficient to achieve at least a log 2.5 reduction, preferably at least a log 3 reduction, more preferably at least a log 4 reduction, and most preferably at least a log 5 reduction in the number of Candida albicans and / or Klebsiella pneumoniae colony forming units on the surface.

[0114] Specifically, with regard to viruses, the compositions of the invention are capable of reducing the viral titer (corresponding to the content of infectious virus present per unit volume in a cell culture lysate) of a viral strain by at least log 4. A log 4 reduction is achieved by reducing the viral titer by at least 10% of the viral strains tested. 4 This corresponds to a 1:1 or 99.99% reduction. The virus may be an enveloped or non-enveloped virus. The virus may be an influenza virus, a coronavirus, or a rhinovirus. In certain embodiments, the virus is a respiratory syncytial virus. In certain embodiments, the virus is an influenza virus H1N1. In certain embodiments, the virus is a coronavirus, such as SARS-CoV, SARS-CoV-1, or SARS-CoV-2.

[0115] Thus, the method may include applying a composition of the invention to a surface containing a population of bacteria and / or fungi (e.g., including Candida albicans and / or Klebsiella pneumoniae) and maintaining the composition in contact with the surface for a period of time sufficient to achieve at least an 80% or at least the equivalent of a log 2.5 reduction in the number of colony forming units of the bacteria and / or fungi (e.g., Candida albicans and / or Klebsiella pneumoniae).

[0116] Preferably, the period of time is not more than 3 minutes, not more than 3 minutes, not more than 2 minutes, not more than 2 minutes, not more than 60 seconds, not more than 60 seconds, specifically 30 seconds to 60 seconds. After the period of time, the surface can be wiped, for example with a cloth or sponge and / or rinsed with water to remove any residual composition. Specifically, the compositions of the present invention have a skin tolerability score of at least 10% average cell viability, at least 11%, at least 12%, at least 13%, at least 14%, or at least 15% average cell viability as measured by an in vitro skin tolerability assay.

[0117] In certain embodiments, there is provided a composition of the invention for use in a method of killing microorganisms, such as Candida albicans, on a surface, the method comprising dispensing the composition from a container onto a surface containing the microorganisms, maintaining the composition in contact with the surface for a period of time sufficient to kill the microorganisms, specifically 30 to 60 seconds, and optionally wiping and / or rinsing the surface to remove the composition.

[0118] Specifically, the surface contains a population of microorganisms, such as Candida albicans. More specifically, the surface is maintained in contact with the composition for a period of time sufficient to kill at least 80%, such as at least 85%, at least 90%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or at least 99.9% of the microorganisms present on the surface. Even more specifically, at least 80%, such as at least 85%, at least 90%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or at least 99.9% of the microorganisms present on the surface are killed within 30 to 60 seconds. Even more specifically, at least 80%, e.g., at least 85%, at least 90%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or at least 99.9% of the Candida albicans CFU present on the surface are killed within 30 to 60 seconds.

[0119] In certain embodiments, there is provided a composition of the invention for use in a method of killing microorganisms, such as Candida albicans, on a surface, the method comprising applying the composition to a surface containing the microorganism, maintaining the composition in contact with the surface for a period of time sufficient to kill the microorganism, specifically 30 to 60 seconds, and optionally wiping and / or rinsing the surface.

[0120] Use of the composition in a cleaning method The present invention further includes methods of cleaning surfaces using the above compositions.

[0121] For example, there is provided a method of cleaning a surface, comprising applying a composition to the surface, maintaining the composition in contact with the surface for a period of time, specifically 30 to 60 seconds, and optionally wiping and / or rinsing the surface.

[0122] In some embodiments, a method of cleaning a surface is provided that includes applying a composition of the present invention to the surface in the form of a spray or foam, maintaining the composition in contact with the surface for a period of time, specifically 30 to 60 seconds, and wiping and / or rinsing the surface to remove the composition.

[0123] Use of the composition in a method for killing microorganisms Also provided are methods of killing microorganisms, such as Candida albicans, on surfaces using the compositions of the invention.

[0124] Further provided is a method of killing microorganisms, such as Candida albicans, on a surface, comprising applying a composition of the invention to a surface containing the microorganisms, maintaining the composition in contact with the surface for a period of time sufficient to kill the microorganisms, specifically 30 to 60 seconds, and optionally wiping and / or rinsing the surface to remove the composition.

[0125] Further provided is a method of killing microorganisms, such as Candida albicans, on a surface, comprising dispensing a composition of the present invention in the form of a spray or foam onto a surface containing the microorganisms, maintaining the composition in contact with the surface for a period of time sufficient to kill the bacteria, specifically 30 to 60 seconds, and optionally wiping and / or rinsing the surface.

[0126] There is also provided a disposable pre-moistened sponge or pad for cleaning hard and / or soft surfaces, comprising (i) a substrate and (ii) a composition of the invention, the substrate being impregnated with the composition. The substrate may comprise cellulose, for example having a cellulose content of from 80 gsm (grams per square meter) to 200 gsm.

[0127] overview The term "comprising" encompasses "including," e.g., a composition "comprising" X may include additional items (e.g., X+Y). In some implementations, the term "comprising" refers to the inclusion of the indicated active agent, e.g., the compound recited, as well as other active agents known in the consumer health industry and generally recognized as safe (GRAS), as well as carriers, excipients, emollients, stabilizers, and the like. Use of the transitional phrase "consisting essentially of" means that the claims are to be construed to include the specific materials or steps recited in the claims, as well as those that do not materially affect the basic and novel characteristics of the claimed invention. See In re Herz, 537 F.2d 549, 551-52, 190 USPQ 461, 463 (CCPA 1976) (emphasis in original); see also MPEP §2111.03. Therefore, the term "consisting essentially of" is not intended to be interpreted as equivalent to "comprising" when used in the claims of the present invention. The term "consisting of" and its variants mean including and limited to (e.g., the specific recited components or steps). In certain regions, the term "comprising an active ingredient consisting of" may be used instead of "consisting essentially of". The term "about" in relation to a numerical value x is optional, meaning that, for example, the numerical value may include some variation around the stated number, such as x±10%, x±5%, x±4%, x±3%, x±2%, or x±1%, to allow for routine experimental variation, measurement variance, or to encompass slight deviations that may achieve substantially the same results as the stated number. The word "substantially" does not exclude "completely", for example, a composition "substantially free" of Y may be completely free of Y.Where appropriate, the word "substantially" may be omitted from the definition of the present invention. When the method refers to process steps, e.g., (a), (b), (c), etc., these are intended to be consecutive, i.e., step (b) preceded by step (a) is followed by step (c). All percentages and ratios used herein are by weight of the total composition unless otherwise specified.

[0128] All references or patent applications cited within this patent specification are hereby incorporated by reference.

[0129] EMBODIMENTS OF THE PRESENT DISCLOSURE The following clauses describe specific embodiments of the present invention:

[0130] E1) An aqueous composition for cleaning hard and / or soft surfaces, comprising about 0.05% to about 4% by weight of hydrogen peroxide, about 0.01% to about 0.25% by weight of at least one acid selected from the group consisting of salicylic acid, furoic acid, and formic acid, and about 0.05% to about 2.00% by weight of an anionic surfactant.

[0131] E2) An aqueous composition for cleaning hard and / or soft surfaces, comprising or consisting essentially of about 0.05% to about 4% by weight hydrogen peroxide, about 0.01% to about 0.25% by weight of at least one acid selected from the group consisting of salicylic acid, furoic acid, and formic acid, about 0.05% to about 2.00% by weight of an anionic surfactant, and having a pH in the range of 2.8 to 3.5.

[0132] E3) An aqueous composition for cleaning hard and / or soft surfaces, comprising or consisting essentially of about 0.05% to about 4% by weight of hydrogen peroxide, about 0.01% to about 0.25% by weight of at least one acid selected from the group consisting of salicylic acid, furoic acid, and formic acid, about 0.05% to about 2.00% by weight of an anionic surfactant, about 0.01% to about 0.08% by weight of a buffer solution, specifically a sodium citrate buffer solution, and having a pH in the range of 2.8 to 3.5.

[0133] E4) An aqueous composition for cleaning hard and / or soft surfaces, comprising or consisting essentially of about 0.05% to about 4% by weight hydrogen peroxide, about 0.01% to about 0.25% by weight of an acid selected from the group consisting of salicylic acid, furoic acid, and formic acid, about 0.05% to about 2.00% by weight of an anionic surfactant, about 0.01% to about 0.08% by weight of a buffer, specifically a sodium citrate buffer, having a pH in the range of 2.8 to 3.5, and further comprising about 0.01% to about 0.5% by weight of a sensory ingredient.

[0134] E5) An aqueous composition for cleaning hard and / or soft surfaces, comprising or consisting essentially of about 0.05% to about 4% by weight hydrogen peroxide, about 0.01% to about 0.25% by weight 2-furoic acid and / or 3-furoic acid, about 0.05% to about 2.00% by weight anionic surfactant, and having a pH in the range of 2.8 to 3.5.

[0135] E6) An aqueous composition for cleaning hard and / or soft surfaces, comprising or consisting essentially of about 0.05% to about 4% by weight hydrogen peroxide, about 0.01% to about 0.25% by weight formic acid, about 0.05% to about 2.00% by weight anionic surfactant, and having a pH in the range of 2.8 to 3.5.

[0136] E7) An aqueous composition for cleaning hard and / or soft surfaces, comprising or consisting essentially of about 0.05% to about 4% by weight hydrogen peroxide, about 0.01% to about 0.25% by weight salicylic acid, about 0.05% to about 2.00% by weight anionic surfactant, and having a pH in the range of 2.8 to 3.5.

[0137] E8) An aqueous composition for cleaning hard and / or soft surfaces, comprising or consisting essentially of about 0.1% to about 2% by weight hydrogen peroxide, about 0.01% to about 0.25% by weight salicylic acid, about 0.05% to about 2.00% by weight anionic surfactant, and having a pH in the range of 2.8 to 3.5.

[0138] E9) An aqueous composition for cleaning hard and / or soft surfaces, comprising or consisting essentially of about 0.1% to about 2% by weight hydrogen peroxide, about 0.01% to about 0.25% by weight salicylic acid, about 0.25% to about 1.00% by weight anionic surfactant, and having a pH in the range of 2.8 to 3.5.

[0139] E10) An aqueous composition for cleaning hard and / or soft surfaces, comprising or consisting essentially of about 0.1% to about 2% by weight hydrogen peroxide, about 0.1% to about 0.2% by weight salicylic acid, about 0.25% to about 1.00% by weight anionic surfactant, and having a pH in the range of 2.8 to 3.5.

[0140] E11) An aqueous composition for cleaning hard and / or soft surfaces, comprising or consisting essentially of about 0.25% to about 1% by weight hydrogen peroxide, about 0.01% to about 0.25% by weight salicylic acid, about 0.05% to about 2.00% by weight anionic surfactant, and having a pH in the range of 2.8 to 3.5.

[0141] E12) An aqueous composition for cleaning hard and / or soft surfaces, comprising or consisting essentially of about 0.25% to about 1% by weight hydrogen peroxide, about 0.1% to about 0.2% by weight salicylic acid, about 0.25% to about 1.00% by weight anionic surfactant, and having a pH in the range of 2.8 to 3.5.

[0142] E13) An aqueous composition for cleaning hard and / or soft surfaces, comprising or consisting essentially of about 0.05% to about 4% by weight hydrogen peroxide, about 0.01% to about 0.25% by weight salicylic acid, about 0.05% to about 2.00% by weight anionic surfactant, about 0.01% to about 0.08% by weight buffer, specifically sodium citrate buffer, and having a pH in the range of 2.8 to 3.5.

[0143] E14) An aqueous composition for cleaning hard and / or soft surfaces, comprising or consisting essentially of about 0.1% to about 2% by weight hydrogen peroxide, about 0.1% to about 0.2% by weight salicylic acid, about 0.25% to about 1.00% by weight anionic surfactant, about 0.01% to about 0.08% by weight buffer, specifically sodium citrate buffer, and having a pH in the range of 2.8 to 3.5.

[0144] E15) An aqueous composition for cleaning hard and / or soft surfaces, comprising or consisting essentially of about 0.1% to about 2% by weight hydrogen peroxide, about 0.1% to about 0.2% by weight salicylic acid, about 0.25% to about 1.00% by weight anionic surfactant, about 0.02% to about 0.06% by weight buffer, specifically sodium citrate buffer, and having a pH in the range of 2.8 to 3.5.

[0145] E16) An aqueous composition for cleaning hard and / or soft surfaces comprising, or consisting essentially of, about 0.1% to about 2% by weight hydrogen peroxide, about 0.1% to about 0.2% by weight salicylic acid, about 0.25% to about 1.00% by weight anionic surfactant, about 0.02% to about 0.08% by weight sodium citrate buffer, and having a pH in the range of 2.8 to 3.5.

[0146] E17) An aqueous composition for cleaning hard and / or soft surfaces, comprising or consisting essentially of about 0.25% to about 1% by weight hydrogen peroxide, about 0.1% to about 0.2% by weight salicylic acid, about 0.25% to about 1.00% by weight anionic surfactant, about 0.01% to about 0.08% by weight buffer, specifically sodium citrate buffer, and having a pH in the range of 2.8 to 3.5.

[0147] E18) An aqueous composition for cleaning hard and / or soft surfaces, comprising or consisting essentially of about 0.25% to about 1% by weight hydrogen peroxide, about 0.1% to about 0.2% by weight salicylic acid, about 0.25% to about 1.00% by weight anionic surfactant, about 0.02% to about 0.08% by weight of a buffer solution, specifically a sodium citrate buffer solution, and having a pH in the range of 2.8 to 3.5.

[0148] E19) An aqueous composition for cleaning hard and / or soft surfaces comprising, or consisting essentially of, about 0.25% to about 1% by weight hydrogen peroxide, about 0.1% to about 0.2% by weight salicylic acid, about 0.25% to about 1.00% by weight anionic surfactant, about 0.02% to about 0.08% by weight sodium citrate buffer, and having a pH in the range of 2.8 to 3.5.

[0149] E20) An aqueous composition for cleaning hard and / or soft surfaces comprising or consisting essentially of about 0.05% to about 4% by weight hydrogen peroxide, about 0.01% to about 0.25% by weight salicylic acid, about 0.05% to about 2.00% by weight anionic surfactant, about 0.01% to about 0.08% by weight buffer, specifically sodium citrate buffer, having a pH in the range of 2.8 to 3.5, and further comprising about 0.01% to about 0.5% by weight of a sensory ingredient.

[0150] E21) An aqueous composition for cleaning hard and / or soft surfaces comprising, or consisting essentially of, about 0.1% to about 2% by weight hydrogen peroxide, about 0.1% to about 0.2% by weight salicylic acid, about 0.25% to about 1.00% by weight anionic surfactant, about 0.02% to about 0.08% by weight sodium citrate buffer, having a pH in the range of 2.8 to 3.5, and further comprising about 0.01% to about 0.5% by weight of a sensory ingredient.

[0151] E22) An aqueous composition for cleaning hard and / or soft surfaces comprising, or consisting essentially of, about 0.1% to about 2% by weight hydrogen peroxide, about 0.1% to about 0.2% by weight salicylic acid, about 0.25% to about 1.00% by weight anionic surfactant, about 0.02% to about 0.08% by weight sodium citrate buffer, having a pH in the range of 2.8 to 3.5, and further comprising about 0.1% to about 0.3% by weight of a sensory ingredient.

[0152] E23) An aqueous composition for cleaning hard and / or soft surfaces comprising, or consisting essentially of, about 0.25% to about 1% by weight hydrogen peroxide, about 0.1% to about 0.2% by weight salicylic acid, about 0.25% to about 1.00% by weight anionic surfactant, about 0.02% to about 0.08% by weight sodium citrate buffer, having a pH in the range of 2.8 to 3.5, and further comprising about 0.01% to about 0.5% by weight of a sensory ingredient.

[0153] E24) An aqueous composition for cleaning hard and / or soft surfaces comprising, or consisting essentially of, about 0.25% to about 1% by weight hydrogen peroxide, about 0.1% to about 0.2% by weight salicylic acid, about 0.25% to about 1.00% by weight anionic surfactant, about 0.02% to about 0.08% by weight sodium citrate buffer, having a pH in the range of 2.8 to 3.5, and further comprising about 0.1% to about 0.3% by weight of a sensory ingredient.

[0154] E25) An aqueous composition for cleaning hard and / or soft surfaces comprising or consisting essentially of about 0.25% to about 1% by weight hydrogen peroxide, about 0.1% to about 0.2% by weight salicylic acid, about 0.25% to about 1.00% by weight sodium lauryl sulfate, about 0.02% to about 0.08% by weight sodium citrate buffer, having a pH in the range of 2.8 to 3.5, and further comprising about 0.1% to about 0.3% by weight of a sensory ingredient.

[0155] E26) An aqueous composition for cleaning hard and / or soft surfaces comprising or consisting essentially of about 0.25% to about 1% by weight hydrogen peroxide, about 0.01% to about 0.25% by weight 2-furoic acid and / or 3-furoic acid, about 0.25% to about 1.00% by weight anionic surfactant, about 0.02% to about 0.08% by weight sodium citrate buffer, having a pH in the range of 2.8 to 3.5, and further comprising about 0.1% to about 0.3% by weight of a sensory ingredient.

[0156] E27) An aqueous composition for cleaning hard and / or soft surfaces comprising or consisting essentially of about 0.25% to about 1% by weight hydrogen peroxide, about 0.01% to about 0.25% by weight 2-furoic acid and / or 3-furoic acid, about 0.25% to about 1.00% by weight sodium lauryl sulfate, about 0.02% to about 0.08% by weight sodium citrate buffer, having a pH in the range of 2.8 to 3.5, and further comprising about 0.1% to about 0.3% by weight of a sensory ingredient.

[0157] E28) An aqueous composition for cleaning hard and / or soft surfaces comprising, or consisting essentially of, about 0.25% to about 1% by weight hydrogen peroxide, about 0.01% to about 0.25% by weight formic acid, about 0.25% to about 1.00% by weight anionic surfactant, about 0.02% to about 0.08% by weight sodium citrate buffer, having a pH in the range of 2.8 to 3.5, and further comprising about 0.1% to about 0.3% by weight of a sensory ingredient.

[0158] E29) An aqueous composition for cleaning hard and / or soft surfaces comprising or consisting essentially of about 0.25% to about 1% by weight hydrogen peroxide, about 0.01% to about 0.25% by weight formic acid, about 0.25% to about 1.00% by weight sodium lauryl sulfate, about 0.02% to about 0.08% by weight sodium citrate buffer, having a pH in the range of 2.8 to 3.5, and further comprising about 0.1% to about 0.3% by weight of a sensory ingredient.

[0159] E30) A disposable pre-moistened sponge or pad for cleaning hard and / or soft surfaces, comprising (i) a substrate and (ii) a composition of the invention, wherein the substrate is impregnated with a composition according to any one of embodiments E1-E29.

[0160] In order that this invention may be better understood, the following examples are set forth. These examples are for illustrative purposes only and are not to be construed as limiting the scope of the invention in any way. EXAMPLES

[0161] [Example 1] Aqueous compositions containing 0.5% hydrogen peroxide, 0.5% sodium lauryl sulfate, acid (for amounts see Table 1), and water (balance to 100%) were prepared and tested for in vitro antimicrobial efficacy against the opportunistic pathogenic yeast Candida albicans.

[0162] The test consisted of applying the composition to a planktonic suspension of Candida albicans (1–5 × 10 8 cfu / ml) and then neutralized after a 60 second contact time. The log reduction of Candida albicans was then calculated for each composition, with a performance goal of >log 5 reduction (99.999% kill).

[0163] [Table 1]

[0164] Of these compositions, only those containing salicylic acid, furoic acid, or formic acid were able to achieve a reduction in colony forming units of C. albicans of ≥ log 2.50. Surprisingly, the composition containing 0.18% salicylic acid provided a reduction of > log 5 (equivalent to 99.99% kill). The other acids tested achieved a reduction of < 1.10 log, demonstrating low levels of antimicrobial efficacy. There is no correlation between the pKa of an acid and antibacterial efficacy.

[0165] [Example 2] The compositions containing salicylic acid were then tested against Klebsiella pneumoniae, a gram-negative bacterium that causes multiple healthcare-associated infections.

[0166] [Table 2]

[0167] These results demonstrate the surprisingly strong antibacterial efficacy of compositions containing salicylic acid.

[0168] [Example 3] Compositions containing water, 0.5% hydrogen peroxide, 0.5% sodium lauryl sulfate, and salicylic acid were prepared at various pH levels and stored at 40° C. for three months to determine the pH range suitable for formulation stability.

[0169] The aged compositions were tested for in vitro antimicrobial efficacy against Candida albicans (60 second contact time as above), as well as for foam appearance after dispensing the liquid compositions through foam pump packaging.

[0170] [Table 3]

[0171] It was observed that formulation pH below pH 2.8 affected foaming properties, leading to a loss of foaming properties after aging of the samples. Without wishing to be bound by theory, it is believed that sodium lauryl sulfate decomposes to insoluble lauryl alcohol below pH 2.8, leading to a gradual loss of foaming properties over time.

[0172] It was also observed that formulations with a pH above 3.5 had lower initial antimicrobial efficacy (3.76 log reduction against Candida albicans at 60 seconds) and declined during storage. Again, without wishing to be bound by theory, it is believed that hydrogen peroxide begins to decompose at less acidic pH, leading to a gradual loss of efficacy over time.

[0173] Accordingly, the optimum pH for stability and antimicrobial efficacy was determined to be in the range of pH 2.8 to pH 3.5.

[0174] [Example 4] A composition (pH 2.8-3.2) containing 0.5% hydrogen peroxide, 0.5% sodium lauryl sulfate, 0.18% salicylic acid, and 98.82% water was prepared.

[0175] In vitro skin tolerability was measured using a commercially available in vitro EPIDERM skin irritation test (EPI-200-SIT, MatTek Corporation), which was described by Kandarova et al. (Pre-validation of an in vitro skin irritation test for medical devices using the reconstructed human tissue model EpiDerm TM Toxicol. In Vitro. 2018;50:407-417). Briefly, 3D tissue models of normal human derived epidermal keratinocytes (NHEK) were cultured and cell viability was measured using well-known cell viability assays. Cultures were then topically exposed to a cleanser solution for 60 seconds and cell viability was remeasured to determine the average % cell viability after product exposure. The target remaining cell viability was defined as 2.71%, representing an excellent skin tolerability profile.

[0176] Material compatibility testing was performed on a wide range of materials, including polymethylmethacrylate, polyamide, stainless steel, silver solder, ethylene vinyl acetate copolymer, thermoplastic polyurethane, cobalt-chromium alloy, and polypropylene. Over multiple cycles, the materials were repeatedly exposed to the composition by brushing for 60 seconds and then rinsing, representing two years of simulated daily use. The materials were then evaluated for surface damage using optical and electron microscopy. The integrity of the materials after exposure was visually graded as either structurally damaged (poor compatibility), with minor cosmetic damage (moderate / good compatibility), or without damage (excellent compatibility).

[0177] [Table 4]

[0178] Surprisingly, the compositions of the present invention provided rapid antimicrobial efficacy within 60 seconds (favorable) despite having low levels of hydrogen peroxide (0.5%).The compositions of the present invention also provided excellent skin tolerability (safety) and material compatibility.

[0179] [Example 5] The stain removal properties of the compositions were evaluated in a simulated stain removal test. A ceramic tile was stained with a strong tea solution. Half of the tile was treated with the composition, brushed, rinsed and dried (Figure 1). The compositions of the present invention effectively removed the stain from the ceramic surface.

[0180] Given this guidance, one of ordinary skill in the art will be able to adjust the parameters given in the examples to achieve similar results within the remit of the claims.

Claims

1. 1. An aqueous cleaning composition comprising: (a) from about 0.05% to about 4% by weight of hydrogen peroxide; (b) from about 0.01% to about 0.25% by weight of at least one acid selected from the group consisting of salicylic acid, furoic acid, and formic acid; (c) from about 0.05% to about 2.00% by weight of an anionic surfactant; and (d) at least about 90% by weight of water, wherein the composition has a pH of 2.8 to 3.

5.

2. 10. The composition of claim 1, further comprising: (e) a means for adjusting or maintaining the pH of the composition.

3. 3. The composition of claim 2, wherein the means for adjusting or maintaining the pH of the composition is a pH buffer.

4. 4. The composition of claim 3, comprising about 0.01% to about 0.08% by weight of a pH buffer.

5. 4. The composition of claim 3, wherein the pH buffer is a sodium citrate buffer.

6. 10. The composition of claim 1, wherein the acid is salicylic acid.

7. 10. The composition of claim 1, comprising about 0.1% to about 2% by weight of hydrogen peroxide, specifically about 0.25% to 1% by weight of hydrogen peroxide.

8. 7. The composition of claim 6, wherein the anionic surfactant is a sodium alkyl sulfate.

9. 9. The composition of claim 8, wherein the sodium alkyl sulfate is selected from the group consisting of sodium lauryl sulfate, sodium lauryl sulfonate, and sodium laureth sulfate.

10. 10. The composition of claim 1, consisting essentially of: (a) about 0.1% to about 2% by weight hydrogen peroxide; (b) about 0.01% to about 0.25% by weight salicylic acid; (c) about 0.05% to about 2.00% by weight anionic surfactant selected from the group consisting of sodium lauryl sulfate, sodium lauryl sulfonate, and sodium laureth sulfate; (d) at least 90% by weight water; and (e) a pH buffer, wherein the composition has a pH of 2.8 to 3.

5.

11. 10. The composition of claim 1, further comprising (f) a sensory ingredient, specifically a flavoring agent, a coloring agent, and / or a bittering agent.

12. 12. A composition according to any one of claims 1 to 11 for use in a method of killing microorganisms, such as Candida albicans, on a surface, the method comprising contacting the microorganisms on the surface with the composition for a period of time sufficient to kill the microorganisms.

13. 12. A method of cleaning a hard surface, the method comprising contacting the hard surface with a composition according to any one of claims 1 to 11 and optionally wiping the hard surface to spread and / or remove the composition.

14. 12. A method of cleaning a soft surface, comprising contacting the soft surface with a composition according to any one of claims 1 to 11 and optionally rinsing the surface to remove the composition.

15. 12. A disposable wettable pad for cleaning hard surfaces, comprising: (i) a substrate; and (ii) the composition of any one of claims 1 to 11, wherein the substrate is impregnated with the composition.

16. 16. A disposable moistened pad according to claim 15 for use in a method for cleaning hard or soft surfaces.

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