Apoptosis inducing agents for the treatment of cancer and immune and autoimmune diseases

Abstract

Compounds that inhibit the activity of anti-apoptotic Bcl-2 proteins, compositions comprising the compounds, and methods of treating diseases during which anti-apoptotic Bcl-2 proteins are expressed are provided.SOLUTION: A compound having the following formula (I) or therapeutically acceptable salts thereof: 4 - {4 - [(4 ' - Chloro-1, 1 ' - biphenyl-2-yl) methyl] piperazin-1-yl} - N - ({3-nitro-4 - [(tetrahydro-benzamide pyran-4-ylmethyl) amino] phenyl} sulphonyl) - 2 - (2H pyrrolo [2, 3-b] pyridin-5-yloxy) 1H.SELECTED DRAWING: None

Claims

1. A compound having the following formula (I) or a therapeutically acceptable salt of said compound: 【Chemistry 1】 [In the formula, A １ is N or C (A ２ ) and A ２ は、H、R １ , OR １ ,SR １ ,S(O)R １ 、SO ２ R １ , C (O) R １ ,C(O)OR １ ,OC(O)R １ ,NHR １ ,N (R) １ ) ２ ,C(O)NHR １ , C (O) N (R １ ) ２ ,NHC (O)R １ ,NR １ C (O) R １ ,NHC (O)O １ ,NR １ C(O)OR １ ,NHC(O)NH ２ 、NXC(O)NXR １ 、NFC(O)N(R １ ) ２ ,NR １ C(O)NHR １ ,NR １ C(O)N(R １ ) ２ 、SO ２ NH ２ 、SO ２ NHR １ 、SO ２ N (R) １ ) ２ 、NHSO ２ R １ ,NR １ SO ２ R １ 、NHSO ２ NHR １ 、NHSO ２ N (R) １ ) ２ ,NR １ SO ２ NHR １ ,NR １ SO ２ N (R) １ ) ２ 、C(O)NXNOH、C(O)NXNOR １ ,C(O)NHSO ２ R １ 、㼣㼈㼮㼨㼉㼮㼨 ２ 、㼣㼈㼮㼨㼉㼮㼨㼲 １ 、C(NH)N(R １ ) ２ NHSO ２ NHR １ 、NHSO ２ N(CH ３ )R １ 、N(CH ３ )SO ２ N(CH ３ )R １ 、F、Cl、Br、I、CN、NO ２ 、N ３ 、OH、C(O)H、CHNOH、CH(NOCH ３ )、CF ３ 、C(O)OH、C(O)NH ２ またはC(O)OR １Ａ であり; B １ は、H、R １ , OR １ ,SR １ ,S(O)R １ 、SO ２ R １ , C (O) R １ ,C(O)OR １ ,OC(O)R １ ,NHR １ ,N (R) １ ) ２ ,C(O)NHR １ , C (O) N (R １ ) ２ ,NHC (O)R １ ,NR １ C (O) R １ ,NHC (O)O １ ,NR １ C(O)OR １ ,NHC(O)NH ２ 、NXC(O)NXR １ 、NFC(O)N(R １ ) ２ ,NR １ C(O)NHR １ ,NR １ C(O)N(R １ ) ２ 、SO ２ NH ２ 、SO ２ NHR １ 、SO ２ N (R) １ ) ２ 、NHSO ２ R １ ,NR １ SO ２ R １ 、NHSO ２ NHR １ 、NHSO ２ N (R) １ ) ２ ,NR １ SO ２ NHR １ ,NR １ SO ２ N (R) １ ) ２ 、C(O)NXNOH、C(O)NXNOR １ ,C(O)NHSO ２ R １ 、㼣㼈㼮㼨㼉㼮㼨 ２ 、㼣㼈㼮㼨㼉㼮㼨㼲 １ 、C(NH)N(R １ ) ２ NHSO ２ NHR １ 、NHSO ２ N(CH ３ )R １ 、N(CH ３ )SO ２ N(CH ３ )R １ 、F、Cl、Br、I、CN、NO ２ 、N ３ 、OH、C(O)H、CHNOH、CH(NOCH ３ )、CF ３ 、C(O)OH、C(O)NH ２ またはC(O)OR １Ａ であり; D １ は、H、R １ , OR １ ,SR １ ,S(O)R １ 、SO ２ R １ , C (O) R １ ,C(O)OR １ ,OC(O)R １ ,NHR １ ,N (R) １ ) ２ ,C(O)NHR １ , C (O) N (R １ ) ２ ,NHC (O)R １ ,NR １ C (O) R １ ,NHC (O)O １ ,NR １ C(O)OR １ ,NHC(O)NH ２ 、NXC(O)NXR １ 、NFC(O)N(R １ ) ２ ,NR １ C(O)NHR １ ,NR １ C(O)N(R １ ) ２ 、SO ２ NH ２ 、SO ２ NHR １ 、SO ２ N (R) １ ) ２ 、NHSO ２ R １ ,NR １ SO ２ R １ 、NHSO ２ NHR １ 、NHSO ２ N (R) １ ) ２ ,NR １ SO ２ NHR １ ,NR １ SO ２ N (R) １ ) ２ 、C(O)NXNOH、C(O)NXNOR １ ,C(O)NHSO ２ R １ 、㼣㼈㼮㼨㼉㼮㼨 ２ 、㼣㼈㼮㼨㼉㼮㼨㼲 １ 、C(NH)N(R １ ) ２ NHSO ２ NHR １ 、NHSO ２ N(CH ３ )R １ 、N(CH ３ )SO ２ N(CH ３ )R １ 、F、Cl、Br、I、CN、NO ２ 、N ３ 、OH、C(O)H、CHNOH、CH(NOCH ３ )、CF ３ 、C(O)OH、C(O)NH ２ またはC(O)OR １Ａ であり; E １ は、H、R １ , OR １ ,SR １ ,S(O)R １ 、SO ２ R １ , C (O) R １ ,C(O)OR １ ,OC(O)R １ ,NHR １ ,N (R) １ ) ２ ,C(O)NHR １ , C (O) N (R １ ) ２ ,NHC (O)R １ ,NR １ C (O) R １ ,NHC (O)O １ ,NR １ C(O)OR １ ,NHC(O)NH ２ 、NXC(O)NXR １ 、NFC(O)N(R １ ) ２ ,NR １ C(O)NHR １ ,NR １ C(O)N(R １ ) ２ 、SO ２ NH ２ 、SO ２ NHR １ 、SO ２ N (R) １ ) ２ 、NHSO ２ R １ ,NR １ SO ２ R １ 、NHSO ２ NHR １ 、NHSO ２ N (R) １ ) ２ ,NR １ SO ２ NHR １ ,NR １ SO ２ N (R) １ ) ２ 、C(O)NXNOH、C(O)NXNOR １ ,C(O)NHSO ２ R １ , C(NH)NH ２ , C(NH)NHR １ , C(NH)N(R １ ) ２ NHSO ２ NHR １ , NHSO ２ N (CH ３ ) R １ , N(CH ３ ) SO ２ N (CH ３ ) R １ , F, Cl, Br, I, CN, NO ２ , N ３ , OH, C(O)H, CHNOH, CH(NOCH ３ ), CF ３ , C(O)OH, C(O)NH ２ or C(O)OR １Ａ and Y １ H, CN, NO ２ , C(O)OH, F, Cl, Br, I, CF ３ , OCF ３ , C.F. ２ CF ３ , OCF ２ CF ３ , R １７ , OR １７ , C(O)R １７ , C(O)OR １７ , S.R. １７ , S.O. ２ R １７ , N.H. ２ , N.H.R. １７ , N(R １７ ) ２ , NHC(O)R １７ , C(O)NH ２ , C(O)NHR １７ , C(O)N(R １７ ) ２ , NHS(O)R １７ or NHSO ２ R １７ or E １ and Y １ together with the atoms to which they are attached are benzene, naphthylene, heteroarene, cycloalkane, cycloalkene, heterocyclic alkane, or heterocyclic alkene; and A ２ 、B １ and D １ are independently selected from H, R １ 、OR １ 、SR １ 、S(O)R １ 、SO ２ R １ 、C(O)R １ 、C(O)OR １ 、OC(O)R １ 、NHR １ 、N(R １ ) ２ 、C(O)NHR １ 、C(O)N(R １ ) ２ 、NHCO)R １ 、NR １ C(O)R １ 、NHCO)OR １ 、NR １ C(O)OR １ 、NHCONH ２ 、NHCONHR １ 、NHCON(R １ ) ２ 、NR １ C(O)NHR １ 、NR １ C(O)N(R １ ) ２ 、SO ２ NH ２ 、SO ２ NH １ 、SO ２ N(R １ ) ２ 、NHSO ２ R １ 、NR １ SO ２ R １ 、NHSO ２ NH １ 、NHSO ２ N(R １ ) ２ 、NR １ SO ２ NH １ 、NR １ SO ２ N(R １ ) ２ 、C(O)NHNOH, C(O)NHNOR １ 、C(O)NHSO ２ R １ 、㼣㼈㼮㼨㼉㼮㼨 ２ 、㼣㼈㼮㼨㼉㼮㼨㼲 １ 、C(NH)N(R １ ) ２ NHSO ２ NHR １ 、NHSO ２ N(CH ３ )R １ 、N(CH ３ )SO ２ N(CH ３ )R １ 、F、Cl、Br、I、CN、NO ２ 、N ３ 、OH、C(O)H、CHNOH、CH(NOCH ３ )、CF ３ 、C(O)OH、C(O)NH ２ またはC(O)OR １Ａ であり;または Y １ and B １ together with the atoms to which they are attached are benzene, naphthylene, heteroarene, cycloalkane, cycloalkene, heterocyclic alkane, or heterocyclic alkene; and A ２ 、 D １ and E １ are independently selected from H, R １ , OR １ , SR １ , S(O)R １ , SO ２ R １ , C(O)R １ , C(O)OR １ , OC(O)R １ , NHR １ , N(R １ ) ２ , C(O)NHR １ , C(O)N(R １ ) ２ , NHCO)R １ , NR １ C(O)R １ , NHCO)OR １ , NR １ C(O)OR １ , NHCONH ２ , NHCONHR １ , NHCON(R １ ) ２ , NR １ C(O)NHR １ , NR １ C(O)N(R １ ) ２ , SO ２ NH ２ , SO ２ NHR １ , SO ２ N(R １ ) ２ , NHSO ２ R １ , NR １ SO ２ R １ , NHSO ２ NHR １ , NHSO ２ N(R １ ) ２ , NR １ SO ２ NHR １ , NR １ SO ２ N(R １ ) ２ , C(O)NHNOH, C(O)NHNOR １ 、C(O)NHSO ２ R １ 、㼣㼈㼮㼨㼉㼮㼨 ２ 、㼣㼈㼮㼨㼉㼮㼨㼲 １ 、C(NH)N(R １ ) ２ NHSO ２ NHR １ 、NHSO ２ N(CH ３ )R １ 、N(CH ３ )SO ２ N(CH ３ )R １ 、F、Cl、Br、I、CN、NO ２ 、N ３ 、OH、C(O)H、CHNOH、CH(NOCH ３ )、CF ３ 、C(O)OH、C(O)NH ２ またはC(O)OR １Ａ であり;または A ２ and B １ together with the atoms to which they are attached are benzene, naphthylene, heteroarene, cycloalkane, cycloalkene, heterocyclic alkane, or heterocyclic alkene; and D １ 、E １ and Y １ are independently selected from H, R １ 、OR １ 、SR １ 、S(O)R １ 、SO ２ R １ 、C(O)R １ 、C(O)OR １ 、OC(O)R １ 、NHR １ 、N(R １ ) ２ 、C(O)NHR １ 、C(O)N(R １ ) ２ 、NH C(O)R １ 、NR １ C(O)R １ 、NH C(O)OR １ 、NR １ C(O)OR １ 、NH C(O)NH<00​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​ １ 、C(O)NHSO ２ R １ 、㼣㼈㼮㼨㼉㼮㼨 ２ 、㼣㼈㼮㼨㼉㼮㼨㼲 １ 、C(NH)N(R １ ) ２ NHSO ２ NHR １ 、NHSO ２ N(CH ３ )R １ 、N(CH ３ )SO ２ N(CH ３ )R １ 、F、Cl、Br、I、CN、NO ２ 、N ３ 、OH、C(O)H、CHNOH、CH(NOCH ３ )、CF ３ 、C(O)OH、C(O)NH ２ またはC(O)OR １Ａ であり;または A ２ and D １ together with the atoms to which they are attached are benzene, naphthalene, heteroarene, cycloalkane, cycloalkene, heterocyclic alkane, or heterocyclic alkene; and B １ 、E １ and Y １ are independently selected from H, R １ 、OR １ 、SR １ 、S(O)R １ 、SO ２ R １ 、C(O)R １ 、C(O)OR １ 、OC(O)R １ 、NHR １ 、N(R １ ) ２ 、C(O)NHR １ 、C(O)N(R １ ) ２ 、NHCO)R １ 、NR １ C(O)R １ 、NHCO)OR １ 、NR １ C(O)OR １ 、NHCONH ２ 、NHCONHR １ 、NHCON(R １ ) ２ 、NR １ C(O)NHR １ 、NR １ C(O)N(R １ ) ２ 、SO ２ NH ２ 、SO ２ NHR １ 、SO ２ N(R １ ) ２ 、NHSO ２ R １ 、NR １ SO ２ R １ 、NHSO ２ NHR １ 、NHSO ２ N(R １ ) ２ 、NR １ SO ２ NHR １ 、NR １ SO ２ N(R １ ) ２ 、C(O)NHNOH, C(O)NHNOR １ 、C(O)NHSO ２ R １ 、㼣㼈㼮㼨㼉㼮㼨 ２ 、㼣㼈㼮㼨㼉㼮㼨㼲 １ 、C(NH)N(R １ ) ２ NHSO ２ NHR １ 、NHSO ２ N(CH ３ )R １ 、N(CH ３ )SO ２ N(CH ３ )R １ 、F、Cl、Br、I、CN、NO ２ 、N ３ 、OH、C(O)H、CHNOH、CH(NOCH ３ )、CF ３ 、C(O)OH、C(O)NH ２ またはC(O)OR １Ａ であり; G １ is H or C(O)OR; R is alkyl; R １ is R ２ , R ３ , R ４ or R ５ and R １Ａ is cycloalkyl, cycloalkenyl or cycloalkynyl; R ２ is not condensed or R ２Ａ is a phenyl fused to R ２Ａ is benzene, heteroarene, cycloalkane, cycloalkene, heterocyclic alkane, or heterocyclic alkene; R ３ is not condensed or R ３Ａ is a heteroaryl fused to ３Ａ is benzene, heteroarene, cycloalkane, cycloalkene, heterocyclic alkane, or heterocyclic alkene; R ４ are uncondensed or R ４Ａ is a cycloalkyl, cycloalkenyl, heterocycloalkyl, or heterocycloalkenyl fused to ４Ａ is benzene, heteroarene, cycloalkane, cycloalkene, heterocyclic alkane, or heterocyclic alkene; R ５ are each unsubstituted or 1, 2, or 3 independently selected R ６ , NC(R ６Ａ ) (R ６Ｂ ), R ７ , OR ７ , S.R. ７ , S(O)R ７ , S.O. ２ R ７ , N.H.R. ７ , N(R ７ ) ２ , C(O)R ７ , C(O)NH ２ , C(O)NHR ７ , C(O)N(R ７ ) ２ , NHC(O)R ７ , N.R. ７ C(O)R ７ , NHSO ２ R ７ , NHC(O)OR ７ , S.O. ２ NH ２ , S.O. ２ NHR ７ , S.O. ２ N (R ７ ) ２ , NHC(O)NH ２ ,NHC(O)NHR ７ ,NHC(O)CH(CH ３ )NHC(O)CH(CH ３ ) NH ２ ,NHC(O)CH(CH ３ )NHC(O)CH(CH ３ ) NHR ７ , OH, (O), C(O)OH, N ３ , C.N., N.H. ２ , C.F. ３ , C.F. ２ CF ３ , alkyl, alkenyl or alkynyl substituted with F, Cl, Br or I; R ６ are unsubstituted or OH, (O), N ３ , C.N., C.F. ３ , C.F. ２ CF ３ , F, Cl, Br, I, NH ２ , NH(CH ３ ) or N(CH ３ ) ２ C substituted with ２ -C ５ is a spiroalkyl; R ６Ａ and R ６Ｂ are independently selected alkyls or together with the N to which they are attached form R ６Ｃ and R ６Ｃ is aziridin-1-yl, azetidin-1-yl, pyrrolidin-1-yl or piperidin-1-yl, each of which is unsubstituted or O, C(O), CNOH, CNOCH ３ ,S,S(O),SO ２ or one CH replaced by NH ２ having a moiety; R ７ is R ８ , R ９ , R １０ or R １１ and R ８ Is not condensed or R ８Ａ is a phenyl fused to R ８Ａ is benzene, heteroarene, cycloalkane, cycloalkene, heterocyclic alkane, or heterocyclic alkene; R ９ is not condensed or R ９Ａ is a heteroaryl fused to ９Ａ is benzene, heteroarene, cycloalkane, cycloalkene, heterocyclic alkane, or heterocyclic alkene; R １０ are uncondensed or R １０Ａ is a cycloalkyl, cycloalkenyl, heterocycloalkyl, or heterocycloalkenyl fused to １０Ａ is benzene, heteroarene, cycloalkane, cycloalkene, heterocyclic alkane, or heterocyclic alkene; R １１ are each unsubstituted or 1, 2, or 3 independently selected R １２ , OR １２ , S.R. １２ , S(O)R １２ , S.O. ２ R １２ , C(O)R １２ , CO(O)R １２ , O.C.(O.)R １２ , OC(O)OR １２ , N.H. ２ , N.H.R. １２ , N(R １２ ) ２ , NHC(O)R １２ , N.R. １２ C(O)R １２ , NHS(O) ２ R １２ , N.R. １２ S (O) ２ R １２ , NHC(O)OR １２ , N.R. １２ C(O)OR １２ , NHC(O)NH ２ ,NHC(O)NHR １２ ,NHC(O)N(R １２ ) ２ , N.R. １２ C(O)NHR １２ , N.R. １２ C(O)N(R １２ ) ２ , C(O)NH ２ , C(O)NHR １２ , C(O)N(R １２ ) ２ , C(O)NHOH, C(O)NHOR １２ , C(O)NHSO ２ R １２ , C(O)NR １２ SO ２ R １２ , S.O. ２ NH ２ , S.O. ２ NHR １２ , S.O. ２ N (R １２ ) ２ , C(O)H, C(O)OH, C(N)NH ２ , C(N)NHR １２ , C(N)N(R １２ ) ２ ,CNOH,CNOCH ３ , OH, (O), CN, N ３ , NO ２ , C.F. ３ , C.F. ２ CF ３ , OCF ３ , OCF ２ CF ３ , alkyl, alkenyl or alkynyl substituted with F, Cl, Br or I; R １２ is R １３ , R １４ , R １５ or R １６ and R １３ is not condensed or R １３Ａ is a phenyl fused to R １３Ａ is benzene, heteroarene, cycloalkane, cycloalkene, heterocyclic alkane, or heterocyclic alkene; R １４ is not condensed or R １４Ａ is a heteroaryl fused to １４Ａ is benzene, heteroarene, cycloalkane, cycloalkene, heterocyclic alkane, or heterocyclic alkene; R １５ are uncondensed or R １５Ａ a cycloalkane, cycloalkene, heterocyclic alkane, or heterocyclic alkene fused with R １５Ａ is benzene, heteroarene, cycloalkane, cycloalkene, heterocyclic alkane, or heterocyclic alkene; R １６ is alkyl, alkenyl, or alkynyl; R １７ is R １８ , R １９ , R ２０ or R ２１ and R １８ Is not condensed or R １８Ａ is a phenyl fused to R １８Ａ is benzene, heteroarene, cycloalkane, cycloalkene, heterocyclic alkane, or heterocyclic alkene; R １９ Is not condensed or R １９Ａ is a heteroaryl fused to １９Ａ is benzene, heteroarene, cycloalkane, cycloalkene, heterocyclic alkane, or heterocyclic alkene; R ２０ are uncondensed or R ２０Ａ is a cycloalkyl, cycloalkenyl, heterocycloalkyl, or heterocycloalkenyl fused to ２０Ａ is benzene, heteroarene, cycloalkane, cycloalkene, heterocyclic alkane, or heterocyclic alkene; R ２１ are each unsubstituted or 1, 2, or 3 independently selected R ２２ , OR ２２ , S.R. ２２ , S(O)R ２２ , S.O. ２ R ２２ , C(O)R ２２ , CO(O)R ２２ , O.C.(O.)R ２２ , OC(O)OR ２２ , N.H. ２ , N.H.R. ２２ , N(R ２２ ) ２ , NHC(O)R ２２ , N.R. ２２ C(O)R ２２ , NHS(O) ２ R ２２ , N.R. ２２ S (O) ２ R ２２ , NHC(O)OR ２２ , N.R. ２２ C(O)OR ２２ , NHC(O)NH ２ ,NHC(O)NHR ２２ ,NHC(O)N(R ２２ ) ２ , N.R. ２２ C(O)NHR ２２ , N.R. ２２ C(O)N(R ２２ ) ２ , C(O)NH ２ , C(O)NHR ２２ , C(O)N(R ２２ ) ２ , C(O)NHOH, C(O)NHOR ２２ , C(O)NHSO ２ R ２２ , C(O)NR ２２ SO ２ R ２２ , S.O. ２ NH ２ , S.O. ２ NHR ２２ , S.O. ２ N (R ２２ ) ２ , C(O)H, C(O)OH, C(N)NH ２ , C(N)NHR ２２ , C(N)N(R ２２ ) ２ ,CNOH,CNOCH ３ , OH, (O), CN, N ３ , NO ２ , C.F. ３ , C.F. ２ CF ３ , OCF ３ , OCF ２ CF ３ , alkyl, alkenyl or alkynyl substituted with F, Cl, Br or I; R ２２ is R ２３ , R ２４ or R ２５ and R ２３ is not condensed or R ２３Ａ is a phenyl fused to R ２３Ａ is benzene, heteroarene, cycloalkane, cycloalkene, heterocyclic alkane, or heterocyclic alkene; R ２４ is not condensed or R ２４Ａ is a heteroarene fused to ２４Ａ is benzene, heteroarene, cycloalkane, cycloalkene, heterocyclic alkane, or heterocyclic alkene; R ２５ are uncondensed or R ２５Ａ is a cycloalkyl, cycloalkenyl, heterocycloalkyl, or heterocycloalkenyl fused to ２５Ａ is benzene, heteroarene, cycloalkane, cycloalkene, heterocyclic alkane, or heterocyclic alkene; Z １ is R ２６ or R ２７ and Z ２ is R ２８ , R ２９ or R ３０ and Z １Ａ and Z ２Ａ are both non-existent or together form CH ２ , C.H. ２ CH ２ or Z １２Ａ It forms; Z １２Ａ is NH, N(CH ３ ), S, S(O) or SO ２ One or two CH replaced by ２ C having a moiety ２ -C ６ - alkylene; L １ は、R ３７ 、OR ３７ 、S ３７ 、S(O)R ３７ 、SO ２ R ３７ 、C(O)R ３７ 、CO(O)R ３７ 、OC(O)R ３７ 、OC(O)OR ３７ 、NHYR ３７ 、C(O)NH、C(O)NR ３７ 、C(O)NHOR ３７ 、C(O)NHSO ２ R ３７ 、SO ２ NH、SO ２ NER ３７ 、C(N)NH、C(N)NHR ３７ ; R ２６ is not condensed or R ２６Ａ phenylene fused to R ２６Ａ is benzene, heteroarene, cycloalkane, cycloalkene, heterocyclic alkane, or heterocyclic alkene; R ２７ is not condensed or R ２７Ａ is heteroarylene fused to ２７Ａ is benzene, heteroarene, cycloalkane, cycloalkene, heterocyclic alkane, or heterocyclic alkene; R ２８ is not condensed or R ２８Ａ phenylene fused to R ２８Ａ is benzene, heteroarene, cycloalkane, cycloalkene, heterocyclic alkane, or heterocyclic alkene; R ２９ is not condensed or R ２９Ａ is heteroarylene fused to ２９Ａ is benzene, heteroarene, cycloalkane, cycloalkene, heterocyclic alkane, or heterocyclic alkene; R ３０ are uncondensed or R ３０Ａ is a cycloalkylene, cycloalkenylene, heterocyclic alkylene, or heterocyclic alkenylene fused with ３０Ａ is benzene, heteroarene, cycloalkane, cycloalkene, heterocyclic alkane, or heterocyclic alkene; R ３７ is a bond or R ３７Ａ and R ３７Ａ are each unsubstituted or 1, 2, or 3 independently selected R ３７Ｂ , OR ３７Ｂ , S.R. ３７Ｂ , S(O)R ３７Ｂ , S.O. ２ R ３７Ｂ , C(O)R ３７Ｂ , CO(O)R ３７Ｂ , O.C.(O.)R ３７Ｂ , OC(O)OR ３７Ｂ , N.H. ２ , N.H.R. ３７Ｂ , N(R ３７Ｂ ) ２ , NHC(O)R ３７Ｂ , N.R. ３７Ｂ C(O)R ３７Ｂ , NHS(O) ２ R ３７Ｂ , N.R. ３７Ｂ S (O) ２ R ３７Ｂ , NHC(O)OR ３７Ｂ , N.R. ３７Ｂ C(O)OR ３７Ｂ , NHC(O)NH ２ ,NHC(O)NHR ３７Ｂ ,NHC(O)N(R ３７Ｂ ) ２ , N.R. ３７Ｂ C(O)NHR ３７Ｂ , N.R. ３７Ｂ C(O)N(R ３７Ｂ ) ２ , C(O)NH ２ , C(O)NHR ３７Ｂ , C(O)N(R ３７Ｂ ) ２ , C(O)NHOH, C(O)NHOR ３７Ｂ , C(O)NHSO ２ R ３７Ｂ , C(O)NR ３７Ｂ SO ２ R ３７Ｂ , S.O. ２ NH ２ , S.O. ２ NHR ３７Ｂ , S.O. ２ N (R ３７Ｂ ) ２ , C(O)H, C(O)OH, C(N)NH ２ , C(N)NHR ３７Ｂ , C(N)N(R ３７Ｂ ) ２ ,CNOH,CNOCH ３ , OH, (O), CN, N ３ , NO ２ , C.F. ３ , C.F. ２ CF ３ , OCF ３ , OCF ２ CF ３ , alkylene, alkenylene, or alkynylene substituted with F, Cl, Br, and I substituents; R ３７Ｂ is alkyl, alkenyl, alkynyl or R ３７Ｃ and R ３７Ｃ is phenyl, heteroaryl, cycloalkyl, cycloalkenyl, heterocycloalkyl, or heterocycloalkenyl; Z ３ is R ３８ , R ３９ or R ４０ and R ３８ Is not condensed or R ３８Ａ is a phenyl fused to R ３８Ａ is benzene, heteroarene, cycloalkane, cycloalkene, heterocyclic alkane, or heterocyclic alkene; R ３９ Is not condensed or R ３９Ａ is a heteroaryl fused to ３９Ａ is benzene, heteroarene, cycloalkane, cycloalkene, heterocyclic alkane, or heterocyclic alkene; R ４０ are uncondensed or R ４０Ａ is a cycloalkyl, cycloalkenyl, heterocycloalkyl, or heterocycloalkenyl fused to ４０Ａ is benzene, heteroarene, cycloalkane, cycloalkene, heterocyclic alkane, or heterocyclic alkene; R ２６ and R ２７ The moiety represented by R ４１ , OR ４１ , S.R. ４１ , S(O)R ４１ , S.O. ２ R ４１ , C(O)R ４１ , CO(O)R ４１ , O.C.(O.)R ４１ , OC(O)OR ４１ , N.H.R. ４１ , N(R ４１ ) ２ , NHC(O)R ４１ , N.R. ４１ C(O)R ４１ , NHS(O) ２ R ４１ , N.R. ４１ S (O) ２ R ４１ , NHC(O)OR ４１ , N.R. ４１ C(O)OR ４１ ,NHC(O)NHR ４１ ,NHC(O)N(R ４１ ) ２ , N.R. ４１ C(O)NHR ４１ , N.R. ４１ C(O)N(R ４１ ) ２ , C(O)NHR ４１ , C(O)N(R ４１ ) ２ , C(O)NHOR ４１ , C(O)NHSO ２ R ４１ , C(O)NR ４１ SO ２ R ４１ , S.O. ２ NHR ４１ , S.O. ２ N (R ４１ ) ２ , C(N)NHR ４１ or C(N)N(R ４１ ) ２ (i.e., Z １Ａ and Z ２Ａ is absent) or further substituted (i.e., Z １Ａ and Z ２Ａ exists); R ４１ is R ４３Ａ is a heteroaryl fused to ４３Ａ is unfused or benzene, heteroarene or R ４３Ｂ benzene, heteroarene, cycloalkane, cycloalkene, heterocyclic alkane, or heterocyclic alkene fused with; R ４３Ｂ is a cycloalkane, cycloalkene, heterocyclic alkane, or heterocyclic alkene; E １ and Y １ is one, Y １ and B １ is one, A ２ and B １ is one, A ２ and D １ is one, R １Ａ , R ２ , R ２Ａ , R ３ , R ３Ａ , R ４ , R ４Ａ , R ６ , R ６Ｃ , R ８ , R ８Ａ , R ９ , R ９Ａ , R １０ , R １０Ａ , R １３ , R １３Ａ , R １４ , R １４Ａ , R １５ , R １５Ａ , R １８ , R １８Ａ , R １９ , R １９Ａ , R ２０ , R ２０Ａ , R ２３ , R ２３Ａ , R ２４ , R ２４Ａ , R ２５ , R ２５Ａ , R ２６ , R ２６Ａ , R ２７ , R ２７Ａ , R ２８ , R ２８Ａ , R ２９ , R ２９Ａ , R ３０ , R ３０Ａ , R ３７Ｂ , R ３８ , R ３８Ａ , R ３９ , R ３９Ａ , R ４０ and R ４０Ａ is independently unsubstituted, further unsubstituted, or contains 1 or 2 or 3 or 4 or 5 independently selected R ５７Ａ , R ５７ , OR ５７ ,SR ５７ ,S(O)R ５７ 、SO ２ R ５７ , C (O) R ５７ ,CO(O)R ５７ ,OC(O)R ５７ ,OC(O)CR ５７ ,NH ２ ,NHR ５７ ,N (R) ５７ ) ２ ,NHC (O)R ５７ ,NR ５７ C (O) R ５７ ,NHS (O) ２ R ５７ ,NR ５７ S (O) ２ R ５７ ,NHC (O)O ５７ ,NR ５７ C(O)OR ５７ ,NHC(O)NH ２ 、NXC(O)NXR ５７ 、NFC(O)N(R ５７ ) ２ ,NR ５７ C(O)NHR ５７ ,NR ５７ C(O)N(R ５７ ) ２ ,C(O)NH ２ ,C(O)NHR ５７ , C (O) N (R ５７ ) ２ 、C(O)NHOH、C(O)NHOR ５７ ,C(O)NHSO ２ R ５７ ,C(O)NR ５７ SO ２ R ５７ 、SO ２ NH ２ 、SO ２ NHR ５７ 、SO ２ N (R) ５７ ) ２ 、C(O)H、C(O)OH、C(N)NH ２ ,C(N)NHR ５７ , C (N) N (R ５７ ) ２ ,CNOH,CNOH ３ , OH, (O), CN, N ３ , NO ２ , C.F. ３ , C.F. ２ CF ３ , OCF ３ , OCF ２ CF ３ , substituted or further substituted with F, Cl, Br or I; R ５７Ａ is spiroalkyl or spiroheteroalkyl; R ５７ is R ５８ , R ５９ , R ６０ or R ６１ and R ５８ Is not condensed or R ５８Ａ is a phenyl fused to R ５８Ａ is benzene, heteroarene, cycloalkane, cycloalkene, heterocyclic alkane, or heterocyclic alkene; R ５９ Is not condensed or R ５９Ａ is a heteroaryl fused to ５９Ａ is benzene, heteroarene, cycloalkane, cycloalkene, heterocyclic alkane, or heterocyclic alkene; R ６０ are not condensed or R ６０Ａ is a cycloalkyl, cycloalkenyl, heterocycloalkyl, or heterocycloalkenyl fused to ６０Ａ is benzene, heteroarene, cycloalkane, cycloalkene, heterocyclic alkane, or heterocyclic alkene; R ６１ are each unsubstituted or one, two, or three independently selected R ６２ , OR ６２ , S.R. ６２ , S(O)R ６２ , S.O. ２ R ６２ , C(O)R ６２ , CO(O)R ６２ , O.C.(O.)R ６２ , OC(O)OR ６２ , N.H. ２ , N.H.R. ６２ , N(R ６２ ) ２ , NHC(O)R ６２ , N.R. ６２ C(O)R ６２ , NHS(O) ２ R ６２ , N.R. ６２ S (O) ２ R ６２ , NHC(O)OR ６２ , N.R. ６２ C(O)OR ６２ , NHC(O)NH ２ ,NHC(O)NHR ６２ ,NHC(O)N(R ６２ ) ２ , N.R. ６２ C(O)NHR ６２ , N.R. ６２ C(O)N(R ６２ ) ２ , C(O)NH ２ , C(O)NHR ６２ , C(O)N(R ６２ ) ２ , C(O)NHOH, C(O)NHOR ６２ , C(O)NHSO ２ R ６２ , C(O)NR ６２ SO ２ R ６２ , S.O. ２ NH ２ , S.O. ２ NHR ６２ , S.O. ２ N (R ６２ ) ２ , C(O)H, C(O)OH, C(N)NH ２ , C(N)NHR ６２ , C(N)N(R ６２ ) ２ ,CNOH,CNOCH ３ , OH, (O), CN, N ３ , NO ２ , C.F. ３ , C.F. ２ CF ３ , OCF ３ , OCF ２ CF ３ , alkyl, alkenyl or alkynyl substituted with F, Cl, Br or I; R ６２ is R ６３ , R ６４ , R ６５ or R ６６ and R ６３ Is not condensed or R ６３Ａ is a phenyl fused to R ６３Ａ is benzene, heteroarene, cycloalkane, cycloalkene, heterocyclic alkane, or heterocyclic alkene; R ６４ Is not condensed or R ６４Ａ is a heteroaryl fused to ６４Ａ is benzene, heteroarene, cycloalkane, cycloalkene, heterocyclic alkane, or heterocyclic alkene; R ６５ are not condensed or R ６５Ａ is a cycloalkyl, cycloalkenyl, heterocycloalkyl, or heterocycloalkenyl fused to ６５Ａ is benzene, heteroarene, cycloalkane, cycloalkene, heterocyclic alkane, or heterocyclic alkene; R ６６ are each unsubstituted or one, two, or three independently selected R ６７ , OR ６７ , S.R. ６７ , S(O)R ６７ , S.O. ２ R ６７ , C(O)R ６７ , CO(O)R ６７ , O.C.(O.)R ６７ , OC(O)OR ６７ , N.H. ２ , N.H.R. ６７ , N(R ６７ ) ２ , NHC(O)R ６７ , N.R. ６７ C(O)R ６７ , NHS(O) ２ R ６７ , N.R. ６７ S (O) ２ R ６７ , NHC(O)OR ６７ , N.R. ６７ C(O)OR ６７ , NHC(O)NH ２ ,NHC(O)NHR ６７ ,NHC(O)N(R ６７ ) ２ , N.R. ６７ C(O)NHR ６７ , N.R. ６７ C(O)N(R ６７ ) ２ , C(O)NH ２ , C(O)NHR ６７ , C(O)N(R ６７ ) ２ , C(O)NHOH, C(O)NHOR ６７ , C(O)NHSO ２ R ６７ , C(O)NR ６７ SO ２ R ６７ , S.O. ２ NH ２ , S.O. ２ NHR ６７ , S.O. ２ N (R ６７ ) ２ , C(O)H, C(O)OH, C(N)NH ２ , C(N)NHR ６７ , C(N)N(R ６７ ) ２ ,CNOH,CNOCH ３ , OH, (O), CN, N ３ , NO ２ , C.F. ３ , C.F. ２ CF ３ , OCF ３ , OCF ２ CF ３ , alkyl, alkenyl or alkynyl substituted with F, Cl, Br or I substituents; R ６７ is alkyl, alkenyl, alkynyl, phenyl, heteroaryl, cycloalkyl, cycloalkenyl, heterocycloalkyl, or heterocycloalkenyl; R ５７Ａ , R ５８ , R ５９ , R ６０ , R ６３ , R ６４ , R ６５ and R ６７ The cyclic moiety represented by is unsubstituted or is substituted with 1 or 2 or 3 or 4 independently selected R ６８ , OR ６８ , S.R. ６８ , S(O)R ６８ , S.O. ２ R ６８ , C(O)R ６８ , CO(O)R ６８ , O.C.(O.)R ６８ , OC(O)OR ６８ , N.H. ２ , N.H.R. ６８ , N(R ６８ ) ２ , NHC(O)R ６８ , N.R. ６８ C(O)R ６８ , NHS(O) ２ R ６８ , N.R. ６８ S (O) ２ R ６８ , NHC(O)OR ６８ , N.R. ６８ C(O)OR ６８ , NHC(O)NH ２ ,NHC(O)NHR ６８ ,NHC(O)N(R ６８ ) ２ , N.R. ６８ C(O)NHR ６８ , N.R. ６８ C(O)N(R ６８ ) ２ , C(O)NH ２ , C(O)NHR ６８ , C(O)N(R ６８ ) ２ , C(O)NHOH, C(O)NHOR ６８ , C(O)NHSO ２ R ６８ , C(O)NR ６８ SO ２ R ６８ , S.O. ２ NH ２ , S.O. ２ NHR ６８ , S.O. ２ N (R ６８ ) ２ , C(O)H, C(O)OH, C(N)NH ２ , C(N)NHR ６８ , C(N)N(R ６８ ) ２ ,CNOH,CNOCH ３ , OH, (O), CN, N ３ , NO ２ , C.F. ３ , C.F. ２ CF ３ , OCF ３ , OCF ２ CF ３ , substituted with F, Cl, Br or I; R ６８ is R ６９ , R ７０ , R ７１ or R ７２ and R ６９ Is not condensed or R ６９Ａ is a phenyl fused to R ６９Ａ is benzene, heteroarene, cycloalkane, cycloalkene, heterocyclic alkane, or heterocyclic alkene; R ７０ is not condensed or R ７０Ａ is a heteroaryl fused to ７０Ａ is benzene, heteroarene, cycloalkane, cycloalkene, heterocyclic alkane, or heterocyclic alkene; R ７１ are uncondensed or R ７１Ａ is a cycloalkyl, cycloalkenyl, heterocycloalkyl, or heterocycloalkenyl fused to ７１Ａ is benzene, heteroarene, cycloalkane, cycloalkene, heterocyclic alkane, or heterocyclic alkene; R ７２ are each unsubstituted or one, two, or three independently selected R ７３ , OR ７３ , S.R. ７３ , S(O)R ７３ , S.O. ２ R ７３ , C(O)R ７３ , CO(O)R ７３ , O.C.(O.)R ７３ , OC(O)OR ７３ , N.H. ２ , N.H.R. ７３ , N(R ７３ ) ２ , NHC(O)R ７３ , N.R. ７３ C(O)R ７３ , NHS(O) ２ R ７３ , N.R. ７３ S (O) ２ R ７３ , NHC(O)OR ７３ , N.R. ７３ C(O)OR ７３ , NHC(O)NH ２ ,NHC(O)NHR ７３ ,NHC(O)N(R ７３ ) ２ , N.R. ７３ C(O)NHR ７３ , N.R. ７３ C(O)N(R ７３ ) ２ , C(O)NH ２ , C(O)NHR ７３ , C(O)N(R ７３ ) ２ , C(O)NHOH, C(O)NHOR ７３ , C(O)NHSO ２ R ７３ , C(O)NR ７３ SO ２ R ７３ , S.O. ２ NH ２ , S.O. ２ NHR ７３ , S.O. ２ N (R ７３ ) ２ , C(O)H, C(O)OH, C(N)NH ２ , C(N)NHR ７３ , C(N)N(R ７３ ) ２ ,CNOH,CNOCH ３ , OH, (O), CN, N ３ , NO ２ , C.F. ３ , C.F. ２ CF ３ , OCF ３ , OCF ２ CF ３ , alkyl, alkenyl or alkynyl substituted with F, Cl, Br or I; R ７３ is alkyl, alkenyl, alkynyl, phenyl, heteroaryl, cycloalkyl, cycloalkenyl, heterocycloalkyl, or heterocycloalkenyl; and R ６９ , R ７０ and R ７１ is unsubstituted or is substituted with 1 or 2 or 3 or 4 independently selected NH ２ , C(O)NH ２ ,C(O)NHOH,SO ２ NH ２ , C.F. ３ , C.F. ２ CF ３ , C(O)H, C(O)OH, C(N)NH ２ , OH, (O), CN, N ３ , NO ２ , C.F. ３ , C.F. ２ CF ３ , OCF ３ , OCF ２ CF ３ , substituted with F, Cl, Br or I.

2. A compound having the following formula (II) or a therapeutically acceptable salt of said compound: 【Chemistry 2】 [In the formula, R １００ is R ２６ As described above for the substituents; n is 0, 1, 2 or 3; A １ is N or C (A ２ ) and A ２ は、H、R １ , OR １ ,SR １ ,S(O)R １ 、SO ２ R １ , C (O) R １ ,C(O)OR １ ,OC(O)R １ ,NHR １ ,N (R) １ ) ２ ,C(O)NHR １ , C (O) N (R １ ) ２ ,NHC (O)R １ ,NR １ C (O) R １ ,NHC (O)O １ ,NR １ C(O)OR １ ,NHC(O)NH ２ 、NXC(O)NXR １ 、NFC(O)N(R １ ) ２ ,NR １ C(O)NHR １ ,NR １ C(O)N(R １ ) ２ 、SO ２ NH ２ 、SO ２ NHR １ 、SO ２ N (R) １ ) ２ 、NHSO ２ R １ ,NR １ SO ２ R １ 、NHSO ２ NHR １ 、NHSO ２ N (R) １ ) ２ ,NR １ SO ２ NHR １ ,NR １ SO ２ N (R) １ ) ２ 、C(O)NXNOH、C(O)NXNOR １ ,C(O)NHSO ２ R １ 、㼣㼈㼮㼨㼉㼮㼨 ２ 、㼣㼈㼮㼨㼉㼮㼨㼲 １ 、C(NH)N(R １ ) ２ NHSO ２ NHR １ 、NHSO ２ N(CH ３ )R １ 、N(CH ３ )SO ２ N(CH ３ )R １ 、F、Cl、Br、I、CN、NO ２ 、N ３ 、OH、C(O)H、CHNOH、CH(NOCH ３ )、CF ３ 、C(O)OH、C(O)NH ２ またはC(O)OR １Ａ であり; B １ は、H、R １ , OR １ ,SR １ ,S(O)R １ 、SO ２ R １ , C (O) R １ ,C(O)OR １ ,OC(O)R １ ,NHR １ ,N (R) １ ) ２ ,C(O)NHR １ , C (O) N (R １ ) ２ ,NHC (O)R １ ,NR １ C (O) R １ ,NHC (O)O １ ,NR １ C(O)OR １ ,NHC(O)NH ２ 、NXC(O)NXR １ 、NFC(O)N(R １ ) ２ ,NR １ C(O)NHR １ ,NR １ C(O)N(R １ ) ２ 、SO ２ NH ２ 、SO ２ NHR １ 、SO ２ N (R) １ ) ２ 、NHSO ２ R １ ,NR １ SO ２ R １ 、NHSO ２ NHR １ 、NHSO ２ N (R) １ ) ２ ,NR １ SO ２ NHR １ ,NR １ SO ２ N (R) １ ) ２ 、C(O)NXNOH、C(O)NXNOR １ ,C(O)NHSO ２ R １ 、㼣㼈㼮㼨㼉㼮㼨 ２ 、㼣㼈㼮㼨㼉㼮㼨㼲 １ 、C(NH)N(R １ ) ２ NHSO ２ NHR １ 、NHSO ２ N(CH ３ )R １ 、N(CH ３ )SO ２ N(CH ３ )R １ 、F、Cl、Br、I、CN、NO ２ 、N ３ 、OH、C(O)H、CHNOH、CH(NOCH ３ )、CF ３ 、C(O)OH、C(O)NH ２ またはC(O)OR １Ａ であり; D １ は、H、R １ , OR １ ,SR １ ,S(O)R １ 、SO ２ R １ , C (O) R １ ,C(O)OR １ ,OC(O)R １ ,NHR １ ,N (R) １ ) ２ ,C(O)NHR １ , C (O) N (R １ ) ２ ,NHC (O)R １ ,NR １ C (O) R １ ,NHC (O)O １ ,NR １ C(O)OR １ ,NHC(O)NH ２ 、NXC(O)NXR １ 、NFC(O)N(R １ ) ２ ,NR １ C(O)NHR １ ,NR １ C(O)N(R １ ) ２ 、SO ２ NH ２ 、SO ２ NHR １ 、SO ２ N (R) １ ) ２ 、NHSO ２ R １ ,NR １ SO ２ R １ 、NHSO ２ NHR １ 、NHSO ２ N (R) １ ) ２ ,NR １ SO ２ NHR １ ,NR １ SO ２ N (R) １ ) ２ 、C(O)NXNOH、C(O)NXNOR １ ,C(O)NHSO ２ R １ 、㼣㼈㼮㼨㼉㼮㼨 ２ 、㼣㼈㼮㼨㼉㼮㼨㼲 １ 、C(NH)N(R １ ) ２ NHSO ２ NHR １ 、NHSO ２ N(CH ３ )R １ 、N(CH ３ )SO ２ N(CH ３ )R １ 、F、Cl、Br、I、CN、NO ２ 、N ３ 、OH、C(O)H、CHNOH、CH(NOCH ３ )、CF ３ 、C(O)OH、C(O)NH ２ またはC(O)OR １Ａ であり; E １ は、H、R １ , OR １ ,SR １ ,S(O)R １ 、SO ２ R １ , C (O) R １ ,C(O)OR １ ,OC(O)R １ ,NHR １ ,N (R) １ ) ２ ,C(O)NHR １ , C (O) N (R １ ) ２ ,NHC (O)R １ ,NR １ C (O) R １ ,NHC (O)O １ ,NR １ C(O)OR １ ,NHC(O)NH ２ 、NXC(O)NXR １ 、NFC(O)N(R １ ) ２ ,NR １ C(O)NHR １ ,NR １ C(O)N(R １ ) ２ 、SO ２ NH ２ 、SO ２ NHR １ 、SO ２ N (R) １ ) ２ 、NHSO ２ R １ ,NR １ SO ２ R １ 、NHSO ２ NHR １ 、NHSO ２ N (R) １ ) ２ ,NR １ SO ２ NHR １ ,NR １ SO ２ N (R) １ ) ２ 、C(O)NXNOH、C(O)NXNOR １ ,C(O)NHSO ２ R １ , C(NH)NH ２ , C(NH)NHR １ , C(NH)N(R １ ) ２ NHSO ２ NHR １ , NHSO ２ N (CH ３ ) R １ , N(CH ３ ) SO ２ N (CH ３ ) R １ , F, Cl, Br, I, CN, NO ２ , N ３ , OH, C(O)H, CHNOH, CH(NOCH ３ ), CF ３ , C(O)OH, C(O)NH ２ or C(O)OR １Ａ and Y １ H, CN, NO ２ , C(O)OH, F, Cl, Br, I, CF ３ , OCF ３ , C.F. ２ CF ３ , OCF ２ CF ３ , R １７ , OR １７ , C(O)R １７ , C(O)OR １７ , S.R. １７ , S.O. ２ R １７ , N.H. ２ , N.H.R. １７ , N(R １７ ) ２ , NHC(O)R １７ , C(O)NH ２ , C(O)NHR １７ , C(O)N(R １７ ) ２ , NHS(O)R １７ or NHSO ２ R １７ or E １ and Y １ together with the atoms to which they are attached are benzene, naphthylene, heteroarene, cycloalkane, cycloalkene, heterocyclic alkane, or heterocyclic alkene; and A ２ 、 B １ and D １ are independently selected from H, R １ , OR １ , SR １ , S(O)R １ , SO ２ R １ , C(O)R １ , C(O)OR １ , OC(O)R １ , NHR １ , N(R １ ) ２ , C(O)NHR １ , C(O)N(R １ ) ２ , NHCO)R １ , NR １ C(O)R １ , NHCO)OR １ , NR １ C(O)OR １ , NHCO)NH ２ , NHCO)NHR １ , NHCO)N(R １ ) ２ , NR １ C(O)NHR １ , NR １ C(O)N(R １ ) ２ , SO<x ２ NH ２ , SO ２ NHR １ , SO ２ N(R １ ) ２ , NHSO ２ R １ , NR １ SO ２ R １ , NHSO ２ NHR １ , NHSO ２ N(R １ ) ２ , NR １ SO ２ NHR １ , NR １ SO ２ N(R １ ) ２ , C(O)NHNOH, C(O)NHNOR １ 、C(O)NHSO ２ R １ 、㼣㼈㼮㼨㼉㼮㼨 ２ 、㼣㼈㼮㼨㼉㼮㼨㼲 １ 、C(NH)N(R １ ) ２ NHSO ２ NHR １ 、NHSO ２ N(CH ３ )R １ 、N(CH ３ )SO ２ N(CH ３ )R １ 、F、Cl、Br、I、CN、NO ２ 、N ３ 、OH、C(O)H、CHNOH、CH(NOCH ３ )、CF ３ 、C(O)OH、C(O)NH ２ またはC(O)OR １Ａ であり;または Y １ and B １ together with the atoms to which they are attached are benzene, naphthylene, heteroarene, cycloalkane, cycloalkene, heterocyclic alkane, or heterocyclic alkene; and A ２ 、 D １ and E １ are independently selected from H, R １ , OR １ , SR １ , S(O)R １ , SO ２ R １ , C(O)R １ , C(O)OR １ , OC(O)R １ , NHR １ , N(R １ ), ２ , C(O)NHR １ , C(O)N(R １ ), ２ , NHCO)R １ , NR １ C(O)R １ , NHCO)OR １ , NR １ C(O)OR １ , NHCONH ２ , NHCONHR １ , NHCON(R １ ), ２ , NR １ C(O)NHR １ , NR １ C(O)N(R １ ), ２ , SO ２ NH ２ , SO ２ NH １ , SO ２ N(R １ ), ２ , NHSO ２ R １ , NR １ SO ２ R １ , NHSO ２ NH １ , NHSO ２ N(R １ ), ２ , NR １ SO ２ NH １ , NR １ SO ２ N(R １ ), ２ , C(O)NHNOH, C(O)NHNOR １ 、C(O)NHSO ２ R １ 、㼣㼈㼮㼨㼉㼮㼨 ２ 、㼣㼈㼮㼨㼉㼮㼨㼲 １ 、C(NH)N(R １ ) ２ NHSO ２ NHR １ 、NHSO ２ N(CH ３ )R １ 、N(CH ３ )SO ２ N(CH ３ )R １ 、F、Cl、Br、I、CN、NO ２ 、N ３ 、OH、C(O)H、CHNOH、CH(NOCH ３ )、CF ３ 、C(O)OH、C(O)NH ２ またはC(O)OR １Ａ であり;または A ２ and B １ together with the atoms to which they are attached are benzene, naphthylene, heteroarene, cycloalkane, cycloalkene, heterocyclic alkane, or heterocyclic alkene; and D １ 、E １ and Y １ are independently selected from H, R １ 、OR １ 、SR １ 、S(O)R １ 、SO ２ R １ 、C(O)R １ 、C(O)OR １ 、OC(O)R １ 、NHR １ 、N(R １ ) ２ 、C(O)NHR １ 、C(O)N(R １ ) ２ 、NH C(O)R １ 、NR １ C(O)R １ 、NH C(O)OR １ 、NR １ C(O)OR １ 、NH C(O)NH ２ 、NH C(O)NHR １ 、NH C(O)N(R １ ) ２ 、NR １ C(O)NHR １ 、NR １ C(O)N(R １ ) ２ 、SO ２ NH ２ 、SO ２ NH R １ 、SO ２ N(R １ ) ２ 、NH SO ２ R １ 、NR １ SO ２ R １ 、NH SO ２ NH R １ 、NH SO ２ N(R １ ) ２ 、NR １ SO ２ NH R １ 、NR １ SO ２ N(R １ ) ２ 、C(O)NHNOH, C(O)NHNOR １ 、C(O)NHSO ２ R １ 、㼣㼈㼮㼨㼉㼮㼨 ２ 、㼣㼈㼮㼨㼉㼮㼨㼲 １ 、C(NH)N(R １ ) ２ NHSO ２ NHR １ 、NHSO ２ N(CH ３ )R １ 、N(CH ３ )SO ２ N(CH ３ )R １ 、F、Cl、Br、I、CN、NO ２ 、N ３ 、OH、C(O)H、CHNOH、CH(NOCH ３ )、CF ３ 、C(O)OH、C(O)NH ２ またはC(O)OR １Ａ であり;または A ２ and D １ together with the atoms to which they are attached are benzene, naphthalene, heteroarene, cycloalkane, cycloalkene, heterocyclic alkane, or heterocyclic alkene; and B １ 、E １ and Y １ are independently selected from H, R １ 、OR １ 、SR １ 、S(O)R １ 、SO ２ R １ 、C(O)R １ 、C(O)OR １ 、OC(O)R １ 、NHR １ 、N(R １ ) ２ 、C(O)NHR １ 、C(O)N(R １ ) ２ 、NHCO)R １ 、NR １ C(O)R １ 、NHCO)OR １ 、NR １ C(O)OR １ 、NHCO)NH ２ 、NHCO)NHR １ 、NHCO)N(R １ ) ２ 、NR １ C(O)NHR １ 、NR １ C(O)N(R １ ) ２ 、SO ２ NH ２ 、SO ２ NH １ 、SO ２ N(R １ ) ２ 、NHSO ２ R １ 、NR １ SO ２ R １ 、NHSO ２ NH １ 、NHSO ２ N(R １ ) ２ 、NR １ SO ２ NH １ 、NR １ SO ２ N(R １ ) ２ 、C(O)NHNOH, C(O)NHNOR １ 、C(O)NHSO ２ R １ 、㼣㼈㼮㼨㼉㼮㼨 ２ 、㼣㼈㼮㼨㼉㼮㼨㼲 １ 、C(NH)N(R １ ) ２ NHSO ２ NHR １ 、NHSO ２ N(CH ３ )R １ 、N(CH ３ )SO ２ N(CH ３ )R １ 、F、Cl、Br、I、CN、NO ２ 、N ３ 、OH、C(O)H、CHNOH、CH(NOCH ３ )、CF ３ 、C(O)OH、C(O)NH ２ またはC(O)OR １Ａ であり; R １ is R ２ , R ３ , R ４ or R ５ and R １Ａ is cycloalkyl, cycloalkenyl or cycloalkynyl; R ２ is not condensed or R ２Ａ is a phenyl fused to R ２Ａ is benzene, heteroarene, cycloalkane, cycloalkene, heterocyclic alkane, or heterocyclic alkene; R ３ is not condensed or R ３Ａ is a heteroaryl fused to ３Ａ is benzene, heteroarene, cycloalkane, cycloalkene, heterocyclic alkane, or heterocyclic alkene; R ４ are uncondensed or R ４Ａ is a cycloalkyl, cycloalkenyl, heterocycloalkyl, or heterocycloalkenyl fused to ４Ａ is benzene, heteroarene, cycloalkane, cycloalkene, heterocyclic alkane, or heterocyclic alkene; R ５ are each unsubstituted or 1, 2, or 3 independently selected R ６ , NC(R ６Ａ ) (R ６Ｂ ), R ７ , OR ７ , S.R. ７ , S(O)R ７ , S.O. ２ R ７ , N.H.R. ７ , N(R ７ ) ２ , C(O)R ７ , C(O)NH ２ , C(O)NHR ７ , C(O)N(R ７ ) ２ , NHC(O)R ７ , N.R. ７ C(O)R ７ , NHSO ２ R ７ , NHC(O)OR ７ , S.O. ２ NH ２ , S.O. ２ NHR ７ , S.O. ２ N (R ７ ) ２ , NHC(O)NH ２ ,NHC(O)NHR ７ ,NHC(O)CH(CH ３ )NHC(O)CH(CH ３ ) NH ２ ,NHC(O)CH(CH ３ )NHC(O)CH(CH ３ ) NHR ７ , OH, (O), C(O)OH, N ３ , C.N., N.H. ２ , C.F. ３ , C.F. ２ CF ３ , alkyl, alkenyl or alkynyl substituted with F, Cl, Br or I; R ６ are unsubstituted or OH, (O), N ３ , C.N., C.F. ３ , C.F. ２ CF ３ , F, Cl, Br, I, NH ２ , NH(CH ３ ) or N(CH ３ ) ２ C substituted with ２ -C ５ is a spiroalkyl; R ６Ａ and R ６Ｂ are independently selected alkyls or together with the N to which they are attached form R ６Ｃ and R ６Ｃ is aziridin-1-yl, azetidin-1-yl, pyrrolidin-1-yl or piperidin-1-yl, each of which is unsubstituted or O, C(O), CNOH, CNOCH ３ ,S,S(O),SO ２ or one CH replaced by NH ２ having a moiety; R ７ is R ８ , R ９ , R １０ or R １１ and R ８ Is not condensed or R ８Ａ is a phenyl fused to R ８Ａ is benzene, heteroarene, cycloalkane, cycloalkene, heterocyclic alkane, or heterocyclic alkene; R ９ is not condensed or R ９Ａ is a heteroaryl fused to ９Ａ is benzene, heteroarene, cycloalkane, cycloalkene, heterocyclic alkane, or heterocyclic alkene; R １０ are uncondensed or R １０Ａ is a cycloalkyl, cycloalkenyl, heterocycloalkyl, or heterocycloalkenyl fused to １０Ａ is benzene, heteroarene, cycloalkane, cycloalkene, heterocyclic alkane, or heterocyclic alkene; R １１ are each unsubstituted or 1, 2, or 3 independently selected R １２ , OR １２ , S.R. １２ , S(O)R １２ , S.O. ２ R １２ , C(O)R １２ , CO(O)R １２ , O.C.(O.)R １２ , OC(O)OR １２ , N.H. ２ , N.H.R. １２ , N(R １２ ) ２ , NHC(O)R １２ , N.R. １２ C(O)R １２ , NHS(O) ２ R １２ , N.R. １２ S (O) ２ R １２ , NHC(O)OR １２ , N.R. １２ C(O)OR １２ , NHC(O)NH ２ ,NHC(O)NHR １２ ,NHC(O)N(R １２ ) ２ , N.R. １２ C(O)NHR １２ , N.R. １２ C(O)N(R １２ ) ２ , C(O)NH ２ , C(O)NHR １２ , C(O)N(R １２ ) ２ , C(O)NHOH, C(O)NHOR １２ , C(O)NHSO ２ R １２ , C(O)NR １２ SO ２ R １２ , S.O. ２ NH ２ , S.O. ２ NHR １２ , S.O. ２ N (R １２ ) ２ , C(O)H, C(O)OH, C(N)NH ２ , C(N)NHR １２ , C(N)N(R １２ ) ２ ,CNOH,CNOCH ３ , OH, (O), CN, N ３ , NO ２ , C.F. ３ , C.F. ２ CF ３ , OCF ３ , OCF ２ CF ３ , alkyl, alkenyl or alkynyl substituted with F, Cl, Br or I; R １２ is R １３ , R １４ , R １５ or R １６ and R １３ is not condensed or R １３Ａ is a phenyl fused to R １３Ａ is benzene, heteroarene, cycloalkane, cycloalkene, heterocyclic alkane, or heterocyclic alkene; R １４ is not condensed or R １４Ａ is a heteroaryl fused to １４Ａ is benzene, heteroarene, cycloalkane, cycloalkene, heterocyclic alkane, or heterocyclic alkene; R １５ are uncondensed or R １５Ａ a cycloalkane, cycloalkene, heterocyclic alkane, or heterocyclic alkene fused with R １５Ａ is benzene, heteroarene, cycloalkane, cycloalkene, heterocyclic alkane, or heterocyclic alkene; R １６ is alkyl, alkenyl, or alkynyl; R １７ is R １８ , R １９ , R ２０ or R ２１ and R １８ Is not condensed or R １８Ａ is a phenyl fused to R １８Ａ is benzene, heteroarene, cycloalkane, cycloalkene, heterocyclic alkane, or heterocyclic alkene; R １９ Is not condensed or R １９Ａ is a heteroaryl fused to １９Ａ is benzene, heteroarene, cycloalkane, cycloalkene, heterocyclic alkane, or heterocyclic alkene; R ２０ are uncondensed or R ２０Ａ is a cycloalkyl, cycloalkenyl, heterocycloalkyl, or heterocycloalkenyl fused to ２０Ａ is benzene, heteroarene, cycloalkane, cycloalkene, heterocyclic alkane, or heterocyclic alkene; R ２１ are each unsubstituted or 1, 2, or 3 independently selected R ２２ , OR ２２ , S.R. ２２ , S(O)R ２２ , S.O. ２ R ２２ , C(O)R ２２ , CO(O)R ２２ , O.C.(O.)R ２２ , OC(O)OR ２２ , N.H. ２ , N.H.R. ２２ , N(R ２２ ) ２ , NHC(O)R ２２ , N.R. ２２ C(O)R ２２ , NHS(O) ２ R ２２ , N.R. ２２ S (O) ２ R ２２ , NHC(O)OR ２２ , N.R. ２２ C(O)OR ２２ , NHC(O)NH ２ ,NHC(O)NHR ２２ ,NHC(O)N(R ２２ ) ２ , N.R. ２２ C(O)NHR ２２ , N.R. ２２ C(O)N(R ２２ ) ２ , C(O)NH ２ , C(O)NHR ２２ , C(O)N(R ２２ ) ２ , C(O)NHOH, C(O)NHOR ２２ , C(O)NHSO ２ R ２２ , C(O)NR ２２ SO ２ R ２２ , S.O. ２ NH ２ , S.O. ２ NHR ２２ , S.O. ２ N (R ２２ ) ２ , C(O)H, C(O)OH, C(N)NH ２ , C(N)NHR ２２ , C(N)N(R ２２ ) ２ ,CNOH,CNOCH ３ , OH, (O), CN, N ３ , NO ２ , C.F. ３ , C.F. ２ CF ３ , OCF ３ , OCF ２ CF ３ , alkyl, alkenyl or alkynyl substituted with F, Cl, Br or I; R ２２ is R ２３ , R ２４ or R ２５ and R ２３ is not condensed or R ２３Ａ is a phenyl fused to R ２３Ａ is benzene, heteroarene, cycloalkane, cycloalkene, heterocyclic alkane, or heterocyclic alkene; R ２４ is not condensed or R ２４Ａ is a heteroarene fused to ２４Ａ is benzene, heteroarene, cycloalkane, cycloalkene, heterocyclic alkane, or heterocyclic alkene; R ２５ are uncondensed or R ２５Ａ is a cycloalkyl, cycloalkenyl, heterocycloalkyl, or heterocycloalkenyl fused to ２５Ａ is benzene, heteroarene, cycloalkane, cycloalkene, heterocyclic alkane, or heterocyclic alkene; Z ２ is R ２８ , R ２９ or R ３０ and L １ は、R ３７ 、OR ３７ 、S ３７ 、S(O)R ３７ 、SO ２ R ３７ 、C(O)R ３７ 、CO(O)R ３７ 、OC(O)R ３７ 、OC(O)OR ３７ 、NHYR ３７ 、C(O)NH、C(O)NR ３７ 、C(O)NHOR ３７ 、C(O)NHSO ２ R ３７ 、SO ２ NH、SO ２ NER ３７ 、C(N)NH、C(N)NHR ３７ ; R ２８ is not condensed or R ２８Ａ phenylene fused to R ２８Ａ is benzene, heteroarene, cycloalkane, cycloalkene, heterocyclic alkane, or heterocyclic alkene; R ２９ is not condensed or R ２９Ａ is heteroarylene fused to ２９Ａ is benzene, heteroarene, cycloalkane, cycloalkene, heterocyclic alkane, or heterocyclic alkene; R ３０ are uncondensed or R ３０Ａ is a cycloalkylene, cycloalkenylene, heterocyclic alkylene, or heterocyclic alkenylene fused with ３０Ａ is benzene, heteroarene, cycloalkane, cycloalkene, heterocyclic alkane, or heterocyclic alkene; R ３７ is a bond or R ３７Ａ and R ３７Ａ are each unsubstituted or 1, 2, or 3 independently selected R ３７Ｂ , OR ３７Ｂ , S.R. ３７Ｂ , S(O)R ３７Ｂ , S.O. ２ R ３７Ｂ , C(O)R ３７Ｂ , CO(O)R ３７Ｂ , O.C.(O.)R ３７Ｂ , OC(O)OR ３７Ｂ , N.H. ２ , N.H.R. ３７Ｂ , N(R ３７Ｂ ) ２ , NHC(O)R ３７Ｂ , N.R. ３７Ｂ C(O)R ３７Ｂ , NHS(O) ２ R ３７Ｂ , N.R. ３７Ｂ S (O) ２ R ３７Ｂ , NHC(O)OR ３７Ｂ , N.R. ３７Ｂ C(O)OR ３７Ｂ , NHC(O)NH ２ ,NHC(O)NHR ３７Ｂ ,NHC(O)N(R ３７Ｂ ) ２ , N.R. ３７Ｂ C(O)NHR ３７Ｂ , N.R. ３７Ｂ C(O)N(R ３７Ｂ ) ２ , C(O)NH ２ , C(O)NHR ３７Ｂ , C(O)N(R ３７Ｂ ) ２ , C(O)NHOH, C(O)NHOR ３７Ｂ , C(O)NHSO ２ R ３７Ｂ , C(O)NR ３７Ｂ SO ２ R ３７Ｂ , S.O. ２ NH ２ , S.O. ２ NHR ３７Ｂ , S.O. ２ N (R ３７Ｂ ) ２ , C(O)H, C(O)OH, C(N)NH ２ , C(N)NHR ３７Ｂ , C(N)N(R ３７Ｂ ) ２ ,CNOH,CNOCH ３ , OH, (O), CN, N ３ , NO ２ , C.F. ３ , C.F. ２ CF ３ , OCF ３ , OCF ２ CF ３ , alkylene, alkenylene, or alkynylene substituted with F, Cl, Br, and I substituents; R ３７Ｂ is alkyl, alkenyl, alkynyl or R ３７Ｃ and R ３７Ｃ is phenyl, heteroaryl, cycloalkyl, cycloalkenyl, heterocycloalkyl, or heterocycloalkenyl; Z ３ is R ３８ , R ３９ or R ４０ and R ３８ Is not condensed or R ３８Ａ is a phenyl fused to R ３８Ａ is benzene, heteroarene, cycloalkane, cycloalkene, heterocyclic alkane, or heterocyclic alkene; R ３９ Is not condensed or R ３９Ａ is a heteroaryl fused to ３９Ａ is benzene, heteroarene, cycloalkane, cycloalkene, heterocyclic alkane, or heterocyclic alkene; R ４０ are uncondensed or R ４０Ａ is a cycloalkyl, cycloalkenyl, heterocycloalkyl, or heterocycloalkenyl fused to ４０Ａ is benzene, heteroarene, cycloalkane, cycloalkene, heterocyclic alkane, or heterocyclic alkene; E １ and Y １ is one, Y １ and B １ is one, A ２ and B １ is one, A ２ and D １ is one, R １Ａ , R ２ , R ２Ａ , R ３ , R ３Ａ , R ４ , R ４Ａ , R ６ , R ６Ｃ , R ８ , R ８Ａ , R ９ , R ９Ａ , R １０ , R １０Ａ , R １３ , R １３Ａ , R １４ , R １４Ａ , R １５ , R １５Ａ , R １８ , R １８Ａ , R １９ , R １９Ａ , R ２０ , R ２０Ａ , R ２３ , R ２３Ａ , R ２４ , R ２４Ａ , R ２５ , R ２５Ａ , R ２６ , R ２６Ａ , R ２７ , R ２７Ａ , R ２８ , R ２８Ａ , R ２９ , R ２９Ａ , R ３０ , R ３０Ａ , R ３７Ｂ , R ３８ , R ３８Ａ , R ３９ , R ３９Ａ , R ４０ and R ４０Ａ is independently unsubstituted, further unsubstituted, or contains 1 or 2 or 3 or 4 or 5 independently selected R ５７Ａ , R ５７ , OR ５７ ,SR ５７ ,S(O)R ５７ 、SO ２ R ５７ , C (O) R ５７ ,CO(O)R ５７ ,OC(O)R ５７ ,OC(O)CR ５７ ,NH ２ ,NHR ５７ ,N (R) ５７ ) ２ ,NHC (O)R ５７ ,NR ５７ C (O) R ５７ ,NHS (O) ２ R ５７ ,NR ５７ S (O) ２ R ５７ ,NHC (O)O ５７ ,NR ５７ C(O)OR ５７ ,NHC(O)NH ２ 、NXC(O)NXR ５７ 、NFC(O)N(R ５７ ) ２ ,NR ５７ C(O)NHR ５７ ,NR ５７ C(O)N(R ５７ ) ２ ,C(O)NH ２ ,C(O)NHR ５７ , C (O) N (R ５７ ) ２ 、C(O)NHOH、C(O)NHOR ５７ ,C(O)NHSO ２ R ５７ ,C(O)NR ５７ SO ２ R ５７ 、SO ２ NH ２ 、SO ２ NHR ５７ 、SO ２ N (R) ５７ ) ２ 、C(O)H、C(O)OH、C(N)NH ２ ,C(N)NHR ５７ , C (N) N (R ５７ ) ２ ,CNOH,CNOH ３ , OH, (O), CN, N ３ , NO ２ , C.F. ３ , C.F. ２ CF ３ , OCF ３ , OCF ２ CF ３ , substituted or further substituted with F, Cl, Br or I; R ５７Ａ is spiroalkyl or heterospiroalkyl; R ５７ is R ５８ , R ５９ , R ６０ or R ６１ and R ５８ Is not condensed or R ５８Ａ is a phenyl fused to R ５８Ａ is benzene, heteroarene, cycloalkane, cycloalkene, heterocyclic alkane, or heterocyclic alkene; R ５９ Is not condensed or R ５９Ａ is a heteroaryl fused to ５９Ａ is benzene, heteroarene, cycloalkane, cycloalkene, heterocyclic alkane, or heterocyclic alkene; R ６０ are not condensed or R ６０Ａ is a cycloalkyl, cycloalkenyl, heterocycloalkyl, or heterocycloalkenyl fused to ６０Ａ is benzene, heteroarene, cycloalkane, cycloalkene, heterocyclic alkane, or heterocyclic alkene; R ６１ are each unsubstituted or one, two, or three independently selected R ６２ , OR ６２ , S.R. ６２ , S(O)R ６２ , S.O. ２ R ６２ , C(O)R ６２ , CO(O)R ６２ , O.C.(O.)R ６２ , OC(O)OR ６２ , N.H. ２ , N.H.R. ６２ , N(R ６２ ) ２ , NHC(O)R ６２ , N.R. ６２ C(O)R ６２ , NHS(O) ２ R ６２ , N.R. ６２ S (O) ２ R ６２ , NHC(O)OR ６２ , N.R. ６２ C(O)OR ６２ , NHC(O)NH ２ ,NHC(O)NHR ６２ ,NHC(O)N(R ６２ ) ２ , N.R. ６２ C(O)NHR ６２ , N.R. ６２ C(O)N(R ６２ ) ２ , C(O)NH ２ , C(O)NHR ６２ , C(O)N(R ６２ ) ２ , C(O)NHOH, C(O)NHOR ６２ , C(O)NHSO ２ R ６２ , C(O)NR ６２ SO ２ R ６２ , S.O. ２ NH ２ , S.O. ２ NHR ６２ , S.O. ２ N (R ６２ ) ２ , C(O)H, C(O)OH, C(N)NH ２ , C(N)NHR ６２ , C(N)N(R ６２ ) ２ ,CNOH,CNOCH ３ , OH, (O), CN, N ３ , NO ２ , C.F. ３ , C.F. ２ CF ３ , OCF ３ , OCF ２ CF ３ , alkyl, alkenyl or alkynyl substituted with F, Cl, Br or I; R ６２ is R ６３ , R ６４ , R ６５ or R ６６ and R ６３ Is not condensed or R ６３Ａ is a phenyl fused to R ６３Ａ is benzene, heteroarene, cycloalkane, cycloalkene, heterocyclic alkane, or heterocyclic alkene; R ６４ Is not condensed or R ６４Ａ is a heteroaryl fused to ６４Ａ is benzene, heteroarene, cycloalkane, cycloalkene, heterocyclic alkane, or heterocyclic alkene; R ６５ are not condensed or R ６５Ａ is a cycloalkyl, cycloalkenyl, heterocycloalkyl, or heterocycloalkenyl fused to ６５Ａ is benzene, heteroarene, cycloalkane, cycloalkene, heterocyclic alkane, or heterocyclic alkene; R ６６ are each unsubstituted or one, two, or three independently selected R ６７ , OR ６７ , S.R. ６７ , S(O)R ６７ , S.O. ２ R ６７ , C(O)R ６７ , CO(O)R ６７ , O.C.(O.)R ６７ , OC(O)OR ６７ , N.H. ２ , N.H.R. ６７ , N(R ６７ ) ２ , NHC(O)R ６７ , N.R. ６７ C(O)R ６７ , NHS(O) ２ R ６７ , N.R. ６７ S (O) ２ R ６７ , NHC(O)OR ６７ , N.R. ６７ C(O)OR ６７ , NHC(O)NH ２ ,NHC(O)NHR ６７ ,NHC(O)N(R ６７ ) ２ , N.R. ６７ C(O)NHR ６７ , N.R. ６７ C(O)N(R ６７ ) ２ , C(O)NH ２ , C(O)NHR ６７ , C(O)N(R ６７ ) ２ , C(O)NHOH, C(O)NHOR ６７ , C(O)NHSO ２ R ６７ , C(O)NR ６７ SO ２ R ６７ , S.O. ２ NH ２ , S.O. ２ NHR ６７ , S.O. ２ N (R ６７ ) ２ , C(O)H, C(O)OH, C(N)NH ２ , C(N)NHR ６７ , C(N)N(R ６７ ) ２ ,CNOH,CNOCH ３ , OH, (O), CN, N ３ , NO ２ , C.F. ３ , C.F. ２ CF ３ , OCF ３ , OCF ２ CF ３ , alkyl, alkenyl, or alkynyl substituted with F, Cl, Br, or I substituents; R ６７ is alkyl, alkenyl, alkynyl, phenyl, heteroaryl, cycloalkyl, cycloalkenyl, heterocycloalkyl, or heterocycloalkenyl; R ５７Ａ , R ５８ , R ５９ , R ６０ , R ６３ , R ６４ , R ６５ and R ６７ The cyclic moiety represented by is unsubstituted or is substituted with 1 or 2 or 3 or 4 independently selected R ６８ , OR ６８ , S.R. ６８ , S(O)R ６８ , S.O. ２ R ６８ , C(O)R ６８ , CO(O)R ６８ , O.C.(O.)R ６８ , OC(O)OR ６８ , N.H. ２ , N.H.R. ６８ , N(R ６８ ) ２ , NHC(O)R ６８ , N.R. ６８ C(O)R ６８ , NHS(O) ２ R ６８ , N.R. ６８ S (O) ２ R ６８ , NHC(O)OR ６８ , N.R. ６８ C(O)OR ６８ , NHC(O)NH ２ ,NHC(O)NHR ６８ ,NHC(O)N(R ６８ ) ２ , N.R. ６８ C(O)NHR ６８ , N.R. ６８ C(O)N(R ６８ ) ２ , C(O)NH ２ , C(O)NHR ６８ , C(O)N(R ６８ ) ２ , C(O)NHOH, C(O)NHOR ６８ , C(O)NHSO ２ R ６８ , C(O)NR ６８ SO ２ R ６８ , S.O. ２ NH ２ , S.O. ２ NHR ６８ , S.O. ２ N (R ６８ ) ２ , C(O)H, C(O)OH, C(N)NH ２ , C(N)NHR ６８ , C(N)N(R ６８ ) ２ ,CNOH,CNOCH ３ , OH, (O), CN, N ３ , NO ２ , C.F. ３ , C.F. ２ CF ３ , OCF ３ , OCF ２ CF ３ , substituted with F, Cl, Br or I; R ６８ is R ６９ , R ７０ , R ７１ or R ７２ and R ６９ Is not condensed or R ６９Ａ is a phenyl fused to R ６９Ａ is benzene, heteroarene, cycloalkane, cycloalkene, heterocyclic alkane, or heterocyclic alkene; R ７０ is not condensed or R ７０Ａ is a heteroaryl fused to ７０Ａ is benzene, heteroarene, cycloalkane, cycloalkene, heterocyclic alkane, or heterocyclic alkene; R ７１ are uncondensed or R ７１Ａ is a cycloalkyl, cycloalkenyl, heterocycloalkyl, or heterocycloalkenyl fused to ７１Ａ is benzene, heteroarene, cycloalkane, cycloalkene, heterocyclic alkane, or heterocyclic alkene; R ７２ are each unsubstituted or one, two, or three independently selected R ７３ , OR ７３ , S.R. ７３ , S(O)R ７３ , S.O. ２ R ７３ , C(O)R ７３ , CO(O)R ７３ , O.C.(O.)R ７３ , OC(O)OR ７３ , N.H. ２ , N.H.R. ７３ , N(R ７３ ) ２ , NHC(O)R ７３ , N.R. ７３ C(O)R ７３ , NHS(O) ２ R ７３ , N.R. ７３ S (O) ２ R ７３ , NHC(O)OR ７３ , N.R. ７３ C(O)OR ７３ , NHC(O)NH ２ ,NHC(O)NHR ７３ ,NHC(O)N(R ７３ ) ２ , N.R. ７３ C(O)NHR ７３ , N.R. ７３ C(O)N(R ７３ ) ２ , C(O)NH ２ , C(O)NHR ７３ , C(O)N(R ７３ ) ２ , C(O)NHOH, C(O)NHOR ７３ , C(O)NHSO ２ R ７３ , C(O)NR ７３ SO ２ R ７３ , S.O. ２ NH ２ , S.O. ２ NHR ７３ , S.O. ２ N (R ７３ ) ２ , C(O)H, C(O)OH, C(N)NH ２ , C(N)NHR ７３ , C(N)N(R ７３ ) ２ ,CNOH,CNOCH ３ , OH, (O), CN, N ３ , NO ２ , C.F. ３ , C.F. ２ CF ３ , OCF ３ , OCF ２ CF ３ , alkyl, alkenyl or alkynyl substituted with F, Cl, Br or I; R ７３ is alkyl, alkenyl, alkynyl, phenyl, heteroaryl, cycloalkyl, cycloalkenyl, heterocycloalkyl, or heterocycloalkenyl; and R ６９ , R ７０ and R ７１ is unsubstituted or is substituted with 1 or 2 or 3 or 4 independently selected NH ２ , C(O)NH ２ ,C(O)NHOH,SO ２ NH ２ , C.F. ３ , C.F. ２ CF ３ , C(O)H, C(O)OH, C(N)NH ２ , OH, (O), CN, N ３ , NO ２ , C.F. ３ , C.F. ２ CF ３ , OCF ３ , OCF ２ CF ３ , substituted with F, Cl, Br or I.

3. G １ is H; A １ is N or C (A ２ ) and A ２ is H The compound of claim 1.

4. G １ is H; A １ is N or C (A ２ ) and A ２ is H; and B １ NHR １ is The compound of claim 1.

5. G １ is H; A １ is N or C (A ２ ) and A ２ is H; B １ NHR １ and D １ is H The compound of claim 1.

6. G １ is H; A １ is N or C (A ２ ) and A ２ is H; B １ NHR １ and D １ is H; and E １ is H The compound of claim 1.

7. G １ is H; A １ is N or C (A ２ ) and A ２ is H; B １ NHR １ and D １ is H; E １ is H; and Y １ But NO ２ is The compound of claim 1.

8. The compound is 4-{4-[(4'-chloro-1,1'-biphenyl-2-yl)methyl]piperazin-1-yl}-N-({3-nitro-4-[(tetrahydro-2H-pyran-4-ylmethyl)amino]phenyl}sulfonyl)-2-(1H-pyrrolo[2,3-b]pyridin-5-yloxy)benzamide; 4-{4-[(4'-chloro-1,1'-biphenyl-2-yl)methyl]piperazin-1-yl}-N-({4-[(3-morpholin-4-ylpropyl)amino]-3-nitrophenyl}sulfonyl)-2-(1H-pyrrolo[2,3-b]pyridin-5-yloxy)benzamide; 4-(4-{[2-(4-chlorophenyl)-4,4-dimethylcyclohex-1-en-1-yl]methyl}piperazin-1-yl)-N-({3-nitro-4-[(1-tetrahydro-2H-pyran-4-ylpiperidin-4-yl)amino]phenyl}sulfonyl)-2-(1H-pyrrolo[2,3-b]pyridin-5-yloxy)benzamide; 4-(4-{[2-(4-chlorophenyl)-4,4-dimethylcyclohex-1-en-1-yl]methyl}piperazin-1-yl)-N-({4-[(1-methylpiperidin-4-yl)amino]-3-nitrophenyl}sulfonyl)-2-(1H-pyrrolo[2,3-b]pyridin-5-yloxy)benzamide; 4-(4-{[2-(4-chlorophenyl)-4,4-dimethylcyclohex-1-en-1-yl]methyl}piperazin-1-yl)-N-({3-nitro-4-[(tetrahydro-2H-pyran-4-ylmethyl)amino]phenyl}sulfonyl)-2-(1H-pyrrolo[2,3-b]pyridin-5-yloxy)benzamide; 4-(4-{[2-(4-chlorophenyl)-4,4-dimethylcyclohex-1-en-1-yl]methyl}piperazin-1-yl)-N-({4-[(4-methylpiperazin-1-yl)amino]-3-nitrophenyl}sulfonyl)-2-(1H-pyrrolo[2,3-b]pyridin-5-yloxy)benzamide; trans-4-(4-{[2-(4-chlorophenyl)-4,4-dimethylcyclohex-1-en-1-yl]methyl}piperazin-1-yl)-N-({4-[(4-morpholin-4-ylcyclohexyl)amino]-3-nitrophenyl}sulfonyl)-2-(1H-pyrrolo[2,3-b]pyridin-5-yloxy)benzamide; 4-(4-{[2-(4-chlorophenyl)-4,4-dimethylcyclohex-1-en-1-yl]methyl}piperazin-1-yl)-N-({4-[(2-methoxyethyl)amino]-3-nitrophenyl}sulfonyl)-2-(1H-pyrrolo[2,3-b]pyridin-5-yloxy)benzamide; 4-(4-{[2-(4-chlorophenyl)-4,4-dimethylcyclohex-1-en-1-yl]methyl}piperazin-1-yl)-N-[(3-nitro-4-{[(3S)-tetrahydro-2H-pyran-3-ylmethyl]amino}phenyl)sulfonyl]-2-(1H-pyrrolo[2,3-b]pyridin-5-yloxy)benzamide; 4-(4-{[2-(4-chlorophenyl)-4,4-dimethylcyclohex-1-en-1-yl]methyl}piperazin-1-yl)-N-{[4-(1,4-dioxan-2-ylmethoxy)-3-nitrophenyl]sulfonyl}-2-(1H-pyrrolo[2,3b]pyridin-5-yloxy)benzamide; 4-(4-{[2-(4-chlorophenyl)-4,4-dimethylcyclohex-1-en-1-yl]methyl}piperazin-1-yl)-N-[(3-nitro-4-{[(3R)-tetrahydro-2H-pyran-3-ylmethyl]amino}phenyl)sulfonyl]-2-(1H-pyrrolo[2,3-b]pyridin-5-yloxy)benzamide; 4-(4-{[2-(4-chlorophenyl)-4,4-dimethylcyclohex-1-en-1-yl]methyl}piperazin-1-yl)-N-(2-naphthylsulfonyl)-2-(1H-pyrrolo[2,3-b]pyridin-5-yloxy)benzamide; 4-(4-{[4-(4-chlorophenyl)-6,6-dimethyl-5,6-dihydro-2H-pyran-3-yl]methyl}piperazin-1-yl)-N-({3-nitro-4-[(tetrahydro-2H-pyran-4-ylmethyl)amino]phenyl}sulfonyl)-2-(1H-pyrrolo[2,3-b]pyridin-5-yloxy)benzamide; 4-(4-{[2-(4-chlorophenyl)-4,4-dimethylcyclohex-1-en-1-yl]methyl}piperazin-1-yl)-N-({4-[(2-methoxyethyl)amino]-3-[(trifluoromethyl)sulfonyl]phenyl}sulfonyl)-2-(1H-pyrrolo[2,3-b]pyridin-5-yloxy)benzamide; 4-(4-{[2-(4-chlorophenyl)-4,4-dimethylcyclohex-1-en-1-yl]methyl}piperazin-1-yl)-2-(1H-pyrrolo[2,3-b]pyridin-5-yloxy)-N-({4-[(tetrahydro-2H-pyran-4-ylmethyl)amino]-3-[(trifluoromethyl)sulfonyl]phenyl}sulfonyl)benzamide; 4-(4-{[2-(4-chlorophenyl)-4,4-dimethylcyclohex-1-en-1-yl]methyl}piperazin-1-yl)-N-{[3-nitro-4-(tetrahydro-2H-pyran-4-ylmethoxy)phenyl]sulfonyl}-2-(1H-pyrrolo[2,3-b]pyridin-5-yloxy)benzamide; 4-(4-{[2-(4-chlorophenyl)-4,4-dimethylcyclohex-1-en-1-yl]methyl}piperazin-1-yl)-N-({4-[(1,4-dioxan-2-ylmethyl)amino]-3-nitrophenyl}sulfonyl)-2-(1H-pyrrolo[2,3-b]pyridin-5-yloxy)benzamide; 4-(4-{[2-(4-chlorophenyl)-4,4-dimethylcyclohex-1-en-1-yl]methyl}piperazin-1-yl)-N-({3-nitro-4-[(2,2,2-trifluoroethyl)amino]phenyl}sulfonyl)-2-(1H-pyrrolo[2,3-b]pyridin-5-yloxy)benzamide; 4-(4-{[2-(4-chlorophenyl)-4,4-dimethylcyclohex-1-en-1-yl]methyl}piperazin-1-yl)-N-({3-nitro-4-[(3,3,3-trifluoropropyl)amino]phenyl}sulfonyl)-2-(1H-pyrrolo[2,3-b]pyridin-5-yloxy)benzamide; 4-(4-{[2-(4-chlorophenyl)-4,4-dimethylcyclohex-1-en-1-yl]methyl}piperazin-1-yl)-N-({4-[(2S)-1,4-dioxan-2-ylmethoxy]-3-nitrophenyl}sulfonyl)-2-(1H-pyrrolo[2,3-b]pyridin-5-yloxy)benzamide; cis-4-(4-{[2-(4-chlorophenyl)-4,4-dimethylcyclohex-1-en-1-yl]methyl}piperazin-1-yl)-N-[(4-{[(4-methoxycyclohexyl)methyl]amino}-3-nitrophenyl)sulfonyl]-2-(1H-pyrrolo[2,3-b]pyridin-5-yloxy)benzamide; 4-(4-{[2-(4-chlorophenyl)-4,4-dimethylcyclohex-1-en-1-yl]methyl}piperazin-1-yl)-N-({4-[(2R)-1,4-dioxan-2-ylmethoxy]-3-nitrophenyl}sulfonyl)-2-(1H-pyrrolo[2,3-b]pyridin-5-yloxy)benzamide; 4-(4-{[4-(4-chlorophenyl)-6,6-dimethyl-5,6-dihydro-2H-pyran-3-yl]methyl}piperazin-1-yl)-N-({4-[(1,4-dioxan-2-ylmethyl)amino]-3-nitrophenyl}sulfonyl)-2-(1H-pyrrolo[2,3-b]pyridin-5-yloxy)benzamide; 4-(4-{[4-(4-chlorophenyl)-6,6-dimethyl-5,6-dihydro-2H-pyran-3-yl]methyl}piperazin-1-yl)-N-{[4-(1,4-dioxan-2-ylmethoxy)-3-nitrophenyl]sulfonyl}-2-(1H-pyrrolo[2,3-b]pyridin-5-yloxy)benzamide; trans-4-(4-{[4-(4-chlorophenyl)-6,6-dimethyl-5,6-dihydro-2H-pyran-3-yl]methyl}piperazin-1-yl)-N-({4-[(4-morpholin-4-ylcyclohexyl)amino]-3-nitrophenyl}sulfonyl)-2-(1H-pyrrolo[2,3-b]pyridin-5-yloxy)benzamide; trans-4-(4-{[2-(4-chlorophenyl)-4,4-dimethylcyclohex-1-en-1-yl]methyl}piperazin-1-yl)-N-[(4-{[(4-methoxycyclohexyl)methyl]amino}-3-nitrophenyl)sulfonyl]-2-(1H-pyrrolo[2,3-b]pyridin-5-yloxy)benzamide; 4-(4-{[4-(4-chlorophenyl)-6,6-dimethyl-5,6-dihydro-2H-pyran-3-yl]methyl}piperazin-1-yl)-N-{[5-cyano-6-(tetrahydro-2H-pyran-4-ylmethoxy)pyridin-3-yl]sulfonyl}-2-(1H-pyrrolo[2,3-b]pyridin-5-yloxy)benzamide; 4-(4-{[2-(4-chlorophenyl)-4,4-dimethylcyclohex-1-en-1-yl]methyl}piperazin-1-yl)-N-{[5-cyano-6-(tetrahydro-2H-pyran-4-ylmethoxy)pyridin-3-yl]sulfonyl}-2-(1H-pyrrolo[2,3-b]pyridin-5-yloxy)benzamide; 4-(4-{[2-(4-chlorophenyl)-4,4-dimethylcyclohex-1-en-1-yl]methyl}piperazin-1-yl)-N-({4-[(4-fluorotetrahydro-2H-pyran-4-yl)methoxy]-3-nitrophenyl}sulfonyl)-2-(1H-pyrrolo[2,3-b]pyridin-5-yloxy)benzamide; N-{[3-(aminocarbonyl)-4-(tetrahydro-2H-pyran-4-ylmethoxy)phenyl]sulfonyl}-4-(4-{[2-(4-chlorophenyl)-4,4-dimethylcyclohex-1-en-1-yl]methyl}piperazin-1-yl)-2-(1H-pyrrolo[2,3-b]pyridin-5-yloxy)benzamide; cis-4-(4-{[2-(4-chlorophenyl)-4,4-dimethylcyclohex-1-en-1-yl]methyl}piperazin-1-yl)-N-({4-[(4-morpholin-4-ylcyclohexyl)amino]-3-nitrophenyl}sulfonyl)-2-(1H-pyrrolo[2,3-b]pyridin-5-yloxy)benzamide; 4-(4-{[2-(4-chlorophenyl)-4,4-dimethylcyclohex-1-en-1-yl]methyl}piperazin-1-yl)-N-{[5-chloro-6-(tetrahydro-2H-pyran-4-ylmethoxy)pyridin-3-yl]sulfonyl}-2-(1H-pyrrolo[2,3-b]pyridin-5-yloxy)benzamide; 4-(4-{[4-(4-chlorophenyl)-6,6-dimethyl-5,6-dihydro-2H-pyran-3-yl]methyl}piperazin-1-yl)-N-{[5-chloro-6-(tetrahydro-2H-pyran-4-ylmethoxy)pyridin-3-yl]sulfonyl}-2-(1H-pyrrolo[2,3-b]pyridin-5-yloxy)benzamide; 4-(4-{[4-(4-chlorophenyl)-6,6-dimethyl-5,6-dihydro-2H-pyran-3-yl]methyl}piperazin-1-yl)-2-(1H-pyrrolo[2,3-b]pyridin-5-yloxy)-N-{[4-[(tetrahydro-2H-pyran-4-ylmethyl)amino]-3-(trifluoromethyl)phenyl]sulfonyl}benzamide; 4-(4-{[4-(4-chlorophenyl)-6,6-dimethyl-5,6-dihydro-2H-pyran-3-yl]methyl}piperazin-1-yl)-2-(1H-pyrrolo[2,3-b]pyridin-5-yloxy)-N-({4-[(tetrahydro-2H-pyran-4-ylmethyl)amino]-3-[(trifluoromethyl)sulfonyl]phenyl}sulfonyl)benzamide; trans-4-(4-{[4-(4-chlorophenyl)-6,6-dimethyl-5,6-dihydro-2H-pyran-3-yl]methyl}piperazin-1-yl)-N-({4-[(4-morpholin-4-ylcyclohexyl)amino]-3-[(trifluoromethyl)sulfonyl]phenyl}sulfonyl)-2-(1H-pyrrolo[2,3-b]pyridin-5-yloxy)benzamide; 4-(4-{[4-(4-chlorophenyl)-6,6-dimethyl-5,6-dihydro-2H-pyran-3-yl]methyl}piperazin-1-yl)-N-({4-[(1-methylpiperidin-4-yl)amino]-3-[(trifluoromethyl)sulfonyl]phenyl}sulfonyl)-2-(1H-pyrrolo[2,3-b]pyridin-5-yloxy)benzamide; 5-({[4-(4-{[2-(4-chlorophenyl)-4,4-dimethylcyclohex-1-en-1-yl]methyl}piperazin-1-yl)-2-(1H-pyrrolo[2,3-b]pyridin-5-yloxy)benzoyl]amino}sulfonyl)-2-(tetrahydro-2H-pyran-4-ylmethoxy)nicotinamide; N-({5-bromo-6-[(1-methylpiperidin-4-yl)methoxy]pyridin-3-yl}sulfonyl)-4-(4-{[2-(4-chlorophenyl)-4,4-dimethylcyclohex-1-en-1-yl]methyl}piperazin-1-yl)-2-(1H-pyrrolo[2,3-b]pyridin-5-yloxy)benzamide; 4-(4-{[2-(4-chlorophenyl)-4,4-dimethylcyclohex-1-en-1-yl]methyl}piperazin-1-yl)-N-({4-[(1-methylpiperidin-4-yl)methoxy]-3-nitrophenyl}sulfonyl)-2-(1H-pyrrolo[2,3-b]pyridin-5-yloxy)benzamide; 4-(4-{[2-(4-chlorophenyl)-4,4-dimethylcyclohex-1-en-1-yl]methyl}piperazin-1-yl)-N-{[5-cyano-6-(1,4-dioxan-2-ylmethoxy)pyridin-3-yl]sulfonyl}-2-(1H-pyrrolo[2,3-b]pyridin-5-yloxy)benzamide; N-{[5-bromo-6-(1,4-dioxan-2-ylmethoxy)pyridin-3-yl]sulfonyl}-4-(4-{[2-(4-chlorophenyl)-4,4-dimethylcyclohex-1-en-1-yl]methyl}piperazin-1-yl)-2-(1H-pyrrolo[2,3-b]pyridin-5-yloxy)benzamide; 4-(4-{[2-(4-chlorophenyl)-4,4-dimethylcyclohex-1-en-1-yl]methyl}piperazin-1-yl)-N-({4-[(2,2-dimethyltetrahydro-2H-pyran-4-yl)methoxy]-3-nitrophenyl}sulfonyl)-2-(1H-pyrrolo[2,3-b]pyridin-5-yloxy)benzamide; N-({3-chloro-5-cyano-4-[(tetrahydro-2H-pyran-4-ylmethyl)amino]phenyl}sulfonyl)-4-(4-{[2-(4-chlorophenyl)-4,4-dimethylcyclohex-1-en-1-yl]methyl}piperazin-1-yl)-2-(1H-pyrrolo[2,3-b]pyridin-5-yloxy)benzamide; N-({4-[(1-acetylpiperidin-4-yl)amino]-3-nitrophenyl}sulfonyl)-4-(4-{[2-(4-chlorophenyl)-4,4-dimethylcyclohex-1-en-1-yl]methyl}piperazin-1-yl)-2-(1H-pyrrolo[2,3-b]pyridin-5-yloxy)benzamide; N-({2-chloro-5-fluoro-4-[(tetrahydro-2H-pyran-4-ylmethyl)amino]phenyl}sulfonyl)-4-(4-{[2-(4-chlorophenyl)-4,4-dimethylcyclohex-1-en-1-yl]methyl}piperazin-1-yl)-2-(1H-pyrrolo[2,3-b]pyridin-5-yloxy)benzamide; 4-(4-{[2-(4-chlorophenyl)-4,4-dimethylcyclohex-1-en-1-yl]methyl}piperazin-1-yl)-N-({4-[(3-morpholin-4-ylpropyl)amino]-3-nitrophenyl}sulfonyl)-2-(1H-pyrrolo[2,3-b]pyridin-5-yloxy)benzamide; 4-(4-{[2-(4-chlorophenyl)-4,4-dimethylcyclohex-1-en-1-yl]methyl}piperazin-1-yl)-N-({5-cyano-6-[(4-fluorotetrahydro-2H-pyran-4-yl)methoxy]pyridin-3-yl}sulfonyl)-2-(1H-pyrrolo[2,3-b]pyridin-5-yloxy)benzamide; 4-(4-{[2-(4-chlorophenyl)-4,4-dimethylcyclohex-1-en-1-yl]methyl}piperazin-1-yl)-N-{[5-cyano-6-(2-morpholin-4-ylethoxy)pyridin-3-yl]sulfonyl}-2-(1H-pyrrolo[2,3-b]pyridin-5-yloxy)benzamide; N-[(3-chloro-4-{[2-(2-methoxyethoxy)ethyl]sulfonyl}phenyl)sulfonyl]-4-(4-{[2-(4-chlorophenyl)-4,4-dimethylcyclohex-1-en-1-yl]methyl}piperazin-1-yl)-2-(1H-pyrrolo[2,3-b]pyridin-5-yloxy)benzamide; 4-(4-{[2-(4-chlorophenyl)-4,4-dimethylcyclohex-1-en-1-yl]methyl}piperazin-1-yl)-N-[(4-{[2-(2-methoxyethoxy)ethyl]sulfonyl}-3-nitrophenyl)sulfonyl]-2-(1H-pyrrolo[2,3-b]pyridin-5-yloxy)benzamide; trans-4-(4-{[2-(4-chlorophenyl)-4,4-dimethylcyclohex-1-en-1-yl]methyl}piperazin-1-yl)-N-({4-[(4-morpholin-4-ylcyclohexyl)oxy]-3-nitrophenyl}sulfonyl)-2-(1H-pyrrolo[2,3-b]pyridin-5-yloxy)benzamide; N-({5-bromo-6-[(1-tetrahydro-2H-pyran-4-ylpiperidin-4-yl)amino]pyridin-3-yl}sulfonyl)-4-(4-{[2-(4-chlorophenyl)-4,4-dimethylcyclohex-1-en-1-yl]methyl}piperazin-1-yl)-2-(1H-pyrrolo[2,3-b]pyridin-5-yloxy)benzamide; 4-(4-{[2-(4-chlorophenyl)-4,4-dimethylcyclohex-1-en-1-yl]methyl}piperazin-1-yl)-N-({4-[(2-cyanoethyl)amino]-3-nitrophenyl}sulfonyl)-2-(1H-pyrrolo[2,3-b]pyridin-5-yloxy)benzamide; cis-4-(4-{[4-(4-chlorophenyl)-6,6-dimethyl-5,6-dihydro-2H-pyran-3-yl]methyl}piperazin-1-yl)-N-({4-[(4-morpholin-4-ylcyclohexyl)amino]-3-nitrophenyl}sulfonyl)-2-(1H-pyrrolo[2,3-b]pyridin-5-yloxy)benzamide; trans-N-{[4-({4-[bis(cyclopropylmethyl)amino]cyclohexyl}amino)-3-nitrophenyl]sulfonyl}-4-(4-{[2-(4-chlorophenyl)-4,4-dimethylcyclohex-1-en-1-yl]methyl}piperazin-1-yl)-2-(1H-pyrrolo[2,3-b]pyridin-5-yloxy)benzamide; 4-(4-{[2-(4-chlorophenyl)-4,4-dimethylcyclohex-1-en-1-yl]methyl}piperazin-1-yl)-N-[(4-{[(1-methylpiperidin-4-yl)methyl]amino}-3-nitrophenyl)sulfonyl]-2-(1H-pyrrolo[2,3-b]pyridin-5-yloxy)benzamide; 4-(4-{[2-(4-chlorophenyl)-4,4-dimethylcyclohex-1-en-1-yl]methyl}piperazin-1-yl)-N-({4-[(morpholin-3-ylmethyl)amino]-3-nitrophenyl}sulfonyl)-2-(1H-pyrrolo[2,3-b]pyridin-5-yloxy)benzamide; 4-(4-{[4-(4-chlorophenyl)-6,6-dimethyl-5,6-dihydro-2H-pyran-3-yl]methyl}piperazin-1-yl)-N-({4-[(4-methylpiperazin-1-yl)amino]-3-nitrophenyl}sulfonyl)-2-(1H-pyrrolo[2,3-b]pyridin-5-yloxy)benzamide; 4-(4-{[2-(4-chlorophenyl)-4,4-dimethylcyclohex-1-en-1-yl]methyl}piperazin-1-yl)-N-({4-[(4-morpholin-4-ylbut-2-ynyl)oxy]-3-nitrophenyl}sulfonyl)-2-(1H-pyrrolo[2,3-b]pyridin-5-yloxy)benzamide; 4-(4-{[2-(4-chlorophenyl)-4,4-dimethylcyclohex-1-en-1-yl]methyl}piperazin-1-yl)-N-{[5-ethynyl-6-(tetrahydro-2H-pyran-4-ylmethoxy)pyridin-3-yl]sulfonyl}-2-(1H-pyrrolo[2,3-b]pyridin-5-yloxy)benzamide; 4-(4-{[2-(4-chlorophenyl)-4,4-dimethylcyclohex-1-en-1-yl]methyl}piperazin-1-yl)-N-[(4-oxo-3,4-dihydroquinazolin-6-yl)sulfonyl]-2-(1H-pyrrolo[2,3-b]pyridin-5-yloxy)benzamide; trans-4-(4-{[8-(4-chlorophenyl)spiro[4.5]dec-7-en-7-yl]methyl}piperazin-1-yl)-N-({4-[(4-morpholin-4-ylcyclohexyl)amino]-3-nitrophenyl}sulfonyl)-2-(1H-pyrrolo[2,3-b]pyridin-5-yloxy)benzamide; cis-4-(4-{[4-(4-chlorophenyl)-6,6-dimethyl-5,6-dihydro-2H-pyran-3-yl]methyl}piperazin-1-yl)-N-[(4-{[(4-methoxycyclohexyl)methyl]amino}-3-nitrophenyl)sulfonyl]-2-(1H-pyrrolo[2,3-b]pyridin-5-yloxy)benzamide; 4-(4-{[8-(4-chlorophenyl)spiro[4.5]dec-7-en-7-yl]methyl}piperazin-1-yl)-N-({4-[(4-fluorotetrahydro-2H-pyran-4-yl)methoxy]-3-nitrophenyl}sulfonyl)-2-(1H-pyrrolo[2,3-b]pyridin-5-yloxy)benzamide; trans-4-(4-{[8-(4-chlorophenyl)spiro[4.5]dec-7-en-7-yl]methyl}piperazin-1-yl)-N-[(4-{[(4-methoxycyclohexyl)methyl]amino}-3-nitrophenyl)sulfonyl]-2-(1H-pyrrolo[2,3-b]pyridin-5-yloxy)benzamide; 4-(4-{[2-(4-chlorophenyl)-5,5-dimethylcyclohex-1-en-1-yl]methyl}piperazin-1-yl)-N-({3-nitro-4-[(tetrahydro-2H-pyran-4-ylmethyl)amino]phenyl}sulfonyl)-2-(1H-pyrrolo[2,3-b]pyridin-5-yloxy)benzamide; 4-(4-{[2-(4-chlorophenyl)-5,5-dimethylcyclohex-1-en-1-yl]methyl}piperazin-1-yl)-N-{[5-cyano-6-(tetrahydro-2H-pyran-4-ylmethoxy)pyridin-3-yl]sulfonyl}-2-(1H-pyrrolo[2,3-b]pyridin-5-yloxy)benzamide; tert-butyl 3-{[4-({[4-(4-{[2-(4-chlorophenyl)-4,4-dimethylcyclohex-1-en-1-yl]methyl}piperazin-1-yl)-2-(1H-pyrrolo[2,3-b]pyridin-5-yloxy)benzoyl]amino}sulfonyl)-2-nitrophenoxy]methyl}morpholine-4-carboxylate; 4-(4-{[2-(4-chlorophenyl)-4,4-dimethylcyclohex-1-en-1-yl]methyl}piperazin-1-yl)-N-{[4-(morpholin-3-ylmethoxy)-3-nitrophenyl]sulfonyl}-2-(1H-pyrrolo[2,3-b]pyridin-5-yloxy)benzamide; 4-(4-{[8-(4-chlorophenyl)spiro[4.5]dec-7-en-7-yl]methyl}piperazin-1-yl)-N-({3-nitro-4-[(tetrahydro-2H-pyran-4-ylmethyl)amino]phenyl}sulfonyl)-2-(1H-pyrrolo[2,3-b]pyridin-5-yloxy)benzamide; 4-(4-{[2-(4-chlorophenyl)-4,4-dimethylcyclohex-1-en-1-yl]methyl}piperazin-1-yl)-N-[(4-{[1-(methylsulfonyl)piperidin-4-yl]amino}-3-nitrophenyl)sulfonyl]-2-(1H-pyrrolo[2,3-b]pyridin-5-yloxy)benzamide; 4-(4-{[2-(4-chlorophenyl)-4,4-dimethylcyclohex-1-en-1-yl]methyl}piperazin-1-yl)-N-({4-[(1,1-dioxidetetrahydro-2H-thiopyran-4-yl)amino]-3-nitrophenyl}sulfonyl)-2-(1H-pyrrolo[2,3-b]pyridin-5-yloxy)benzamide; N-[(4-chloro-3-nitrophenyl)sulfonyl]-4-(4-{[2-(4-chlorophenyl)-4,4-dimethylcyclohex-1-en-1-yl]methyl}piperazin-1-yl)-2-(1H-pyrrolo[2,3-b]pyridin-5-yloxy)benzamide; 4-(4-{[2-(4-chlorophenyl)-4,4-dimethylcyclohex-1-en-1-yl]methyl}piperazin-1-yl)-N-[(3-nitro-4-{[1-(2,2,2-trifluoroethyl)piperidin-4-yl]amino}phenyl)sulfonyl]-2-(1H-pyrrolo[2,3-b]pyridin-5-yloxy)benzamide; 4-(4-{[2-(4-chlorophenyl)-4,4-dimethylcyclohex-1-en-1-yl]methyl}piperazin-1-yl)-N-({5-cyano-6-[(1-tetrahydro-2H-pyran-4-ylpiperidin-4-yl)oxy]pyridin-3-yl}sulfonyl)-2-(1H-pyrrolo[2,3-b]pyridin-5-yloxy)benzamide; 4-(4-{[2-(4-chlorophenyl)-4,4-dimethylcyclohex-1-en-1-yl]methyl}piperazin-1-yl)-N-{[5-isopropyl-6-(tetrahydro-2H-pyran-4-ylmethoxy)pyridin-3-yl]sulfonyl}-2-(1H-pyrrolo[2,3-b]pyridin-5-yloxy)benzamide; N-({3-chloro-5-fluoro-4-[(tetrahydro-2H-pyran-4-ylmethyl)amino]phenyl}sulfonyl)-4-(4-{[2-(4-chlorophenyl)-4,4-dimethylcyclohex-1-en-1-yl]methyl}piperazin-1-yl)-2-(1H-pyrrolo[2,3-b]pyridin-5-yloxy)benzamide; and therapeutically acceptable salts and metabolites thereof; 4-(4-{[2-(4-chlorophenyl)-4,4-dimethylcyclohex-1-en-1-yl]methyl}piperazin-1-yl)-N-{[4-({1-[2-fluoro-1-(fluoromethyl)ethyl]piperidin-4-yl}amino)-3-nitrophenyl]sulfonyl}-2-(1H-pyrrolo[2,3-b]pyridin-5-yloxy)benzamide; N-({5-chloro-6-[(4-fluorotetrahydro-2H-pyran-4-yl)methoxy]pyridin-3-yl}sulfonyl)-4-(4-{[2-(4-chlorophenyl)-4,4-dimethylcyclohex-1-en-1-yl]methyl}piperazin-1-yl)-2-(1H-pyrrolo[2,3-b]pyridin-5-yloxy)benzamide; 4-(4-{[2-(4-chlorophenyl)-4,4-dimethylcyclohex-1-en-1-yl]methyl}piperazin-1-yl)-N-[(4-{[1-(2,2-difluoroethyl)piperidin-4-yl]amino}-3-nitrophenyl)sulfonyl]-2-(1H-pyrrolo[2,3-b]pyridin-5-yloxy)benzamide; 4-(4-{[2-(4-chlorophenyl)-4,4-dimethylcyclohex-1-en-1-yl]methyl}piperazin-1-yl)-N-({4-[(1-cyclopropylpiperidin-4-yl)amino]-3-nitrophenyl}sulfonyl)-2-(1H-pyrrolo[2,3-b]pyridin-5-yloxy)benzamide; 4-(4-{[2-(4-chlorophenyl)-4,4-dimethylcyclohex-1-en-1-yl]methyl}piperazin-1-yl)-N-[(4-{[(1-morpholin-4-ylcyclohexyl)methyl]amino}-3-nitrophenyl)sulfonyl]-2-(1H-pyrrolo[2,3-b]pyridin-5-yloxy)benzamide; trans-4-(4-{[2-(4-chlorophenyl)-4,4-dimethylcyclohex-1-en-1-yl]methyl}piperazin-1-yl)-N-[(4-{[4-(dicyclopropylamino)cyclohexyl]amino}-3-nitrophenyl)sulfonyl]-2-(1H-pyrrolo[2,3-b]pyridin-5-yloxy)benzamide; 4-(4-{[2-(4-chlorophenyl)-6,6-dimethylcyclohex-1-en-1-yl]methyl}piperazin-1-yl)-N-({3-nitro-4-[(tetrahydro-2H-pyran-4-ylmethyl)amino]phenyl}sulfonyl)-2-(1H-pyrrolo[2,3-b]pyridin-5-yloxy)benzamide; N-({5-bromo-6-[(4-ethylmorpholin-3-yl)methoxy]pyridin-3-yl}sulfonyl)-4-(4-{[2-(4-chlorophenyl)-4,4-dimethylcyclohex-1-en-1-yl]methyl}piperazin-1-yl)-2-(1H-pyrrolo[2,3-b]pyridin-5-yloxy)benzamide; 4-(4-{[2-(4-chlorophenyl)-4,4-dimethylcyclohex-1-en-1-yl]methyl}piperazin-1-yl)-N-({4-[(4-ethylmorpholin-3-yl)methoxy]-3-nitrophenyl}sulfonyl)-2-(1H-pyrrolo[2,3-b]pyridin-5-yloxy)benzamide; 4-(4-{[2-(4-chlorophenyl)-4,4-dimethylcyclohex-1-en-1-yl]methyl}piperazin-1-yl)-N-({3-nitro-4-[(4-tetrahydro-2H-pyran-4-ylmorpholin-3-yl)methoxy]phenyl}sulfonyl)-2-(1H-pyrrolo[2,3-b]pyridin-5-yloxy)benzamide; 4-(4-{[2-(4-chlorophenyl)-4,4-dimethylcyclohex-1-en-1-yl]methyl}piperazin-1-yl)-N-[(3-nitro-4-{[(3S)-1-tetrahydro-2H-pyran-4-ylpiperidin-3-yl]amino}phenyl)sulfonyl]-2-(1H-pyrrolo[2,3-b]pyridin-5-yloxy)benzamide; 4-(4-{[2-(4-chlorophenyl)-4,4-dimethylcyclohex-1-en-1-yl]methyl}piperazin-1-yl)-N-({5-cyano-6-[(tetrahydro-2H-pyran-4-ylmethyl)amino]pyridin-3-yl}sulfonyl)-2-(1H-pyrrolo[2,3-b]pyridin-5-yloxy)benzamide; 4-(4-{[2-(4-chlorophenyl)-4,4-dimethylcyclohex-1-en-1-yl]methyl}piperazin-1-yl)-N-({4-[(1,1-dioxidethiomorpholin-4-yl)amino]-3-nitrophenyl}sulfonyl)-2-(1H-pyrrolo[2,3-b]pyridin-5-yloxy)benzamide; N-[(4-{[(4-aminotetrahydro-2H-pyran-4-yl)methyl]amino}-3-nitrophenyl)sulfonyl]-4-(4-{[2-(4-chlorophenyl)-4,4-dimethylcyclohex-1-en-1-yl]methyl}piperazin-1-yl)-2-(1H-pyrrolo[2,3-b]pyridin-5-yloxy)benzamide; trans-4-(4-{[2-(4-chlorophenyl)-4,4-dimethylcyclohex-1-en-1-yl]methyl}piperazin-1-yl)-N-({5-cyano-6-[(4-morpholin-4-ylcyclohexyl)amino]pyridin-3-yl}sulfonyl)-2-(1H-pyrrolo[2,3-b]pyridin-5-yloxy)benzamide; 4-(4-{[2-(4-chlorophenyl)-4,4-dimethylcyclohex-1-en-1-yl]methyl}piperazin-1-yl)-N-({3-cyano-4-[(tetrahydro-2H-pyran-4-ylmethyl)amino]phenyl}sulfonyl)-2-(1H-pyrrolo[2,3-b]pyridin-5-yloxy)benzamide; 4-(4-{[2-(4-chlorophenyl)-4,4-dimethylcyclohex-1-en-1-yl]methyl}piperazin-1-yl)-N-[(4-{[(1S,3R)-3-morpholin-4-ylcyclopentyl]amino}-3-nitrophenyl)sulfonyl]-2-(1H-pyrrolo[2,3-b]pyridin-5-yloxy)benzamide; 4-(4-{[2-(4-chlorophenyl)-4,4-dimethylcyclohex-1-en-1-yl]methyl}piperazin-1-yl)-N-[(4-{[(1R,3S)-3-morpholin-4-ylcyclopentyl]amino}-3-nitrophenyl)sulfonyl]-2-(1H-pyrrolo[2,3-b]pyridin-5-yloxy)benzamide; 4-(4-{[2-(4-chlorophenyl)-4,4-dimethylcyclohex-1-en-1-yl]methyl}piperazin-1-yl)-N-({4-[(morpholin-2-ylmethyl)amino]-3-nitrophenyl}sulfonyl)-2-(1H-pyrrolo[2,3-b]pyridin-5-yloxy)benzamide; 4-(4-{[2-(4-chlorophenyl)-4,4-dimethylcyclohex-1-en-1-yl]methyl}piperazin-1-yl)-N-({3-nitro-4-[(tetrahydrofuran-3-ylmethyl)amino]phenyl}sulfonyl)-2-(1H-pyrrolo[2,3-b]pyridin-5-yloxy)benzamide; 4-(4-{[2-(4-chlorophenyl)-4,4-dimethylcyclohex-1-en-1-yl]methyl}piperazin-1-yl)-N-{[4-({1-[cis-3-fluorotetrahydro-2H-pyran-4-yl]piperidin-4-yl}amino)-3-nitrophenyl]sulfonyl}-2-(1H-pyrrolo[2,3-b]pyridin-5-yloxy)benzamide; 4-(4-{[2-(4-chlorophenyl)-4,4-dimethylcyclohex-1-en-1-yl]methyl}piperazin-1-yl)-N-({3-nitro-4-[(1-tetrahydro-2H-pyran-4-ylazetidin-3-yl)amino]phenyl}sulfonyl)-2-(1H-pyrrolo[2,3-b]pyridin-5-yloxy)benzamide; 4-(4-{[2-(4-chlorophenyl)-4,4-dimethylcyclohex-1-en-1-yl]methyl}piperazin-1-yl)-N-({3-nitro-4-[(1-tetrahydrofuran-3-ylazetidin-3-yl)amino]phenyl}sulfonyl)-2-(1H-pyrrolo[2,3-b]pyridin-5-yloxy)benzamide; 4-(4-{[2-(4-chlorophenyl)-4,4-dimethylcyclohex-1-en-1-yl]methyl}piperazin-1-yl)-N-{[3-nitro-4-({[(3R)-1-tetrahydro-2H-pyran-4-ylpyrrolidin-3-yl]methyl}amino)phenyl]sulfonyl}-2-(1H-pyrrolo[2,3-b]pyridin-5-yloxy)benzamide; 4-(4-{[2-(4-chlorophenyl)-5,5-dimethylcyclohex-1-en-1-yl]methyl}piperazin-1-yl)-N-({4- [(4-fluorotetrahydro-2H-pyran-4-yl)methoxy]-3-nitrophenyl}sulfonyl)-2-(1H-pyrrolo[2,3-b]pyridin-5-yloxy)benzamide; 2-(1H-pyrrolo[2,3-b]pyridin-5-yloxy)-4-(4-((2-(4-chlorophenyl)-4,4-dimethylcyclohex-1-enyl)methyl)piperazin-1-yl)-N-(4-((trans-4-hydroxycyclohexyl)methoxy)-3-nitrophenylsulfonyl)benzamide; 2-(1H-pyrrolo[2,3-b]pyridin-5-yloxy)-4-(4-((2-(4-chlorophenyl)-4,4-dimethylcyclohex-1-enyl)methyl)piperazin-1-yl)-N-(4-((cis-4-methoxycyclohexyl)methoxy)-3-nitrophenylsulfonyl)benzamide; cis-4-(4-{[2-(4-chlorophenyl)-4,4-dimethylcyclohex-1-en-1-yl]methyl}piperazin-1-yl)-N-[(4-{[4-(cyclopropylamino)cyclohexyl]amino}-3-nitrophenyl)sulfonyl]-2-(1H-pyrrolo[2,3-b]pyridin-5-yloxy)benzamide; trans-4-(4-{[2-(4-chlorophenyl)-4,4-dimethylcyclohex-1-en-1-yl]methyl}piperazin-1-yl)-N-[(3-nitro-4-{[4-(tetrahydro-2H-pyran-4-ylamino)cyclohexyl]amino}phenyl)sulfonyl]-2-(1H-pyrrolo[2,3-b]pyridin-5-yloxy)benzamide; trans-N-({5-bromo-6-[(4-morpholin-4-ylcyclohexyl)oxy]pyridin-3-yl}sulfonyl)-4-(4-{[2-(4-chlorophenyl)-4,4-dimethylcyclohex-1-en-1-yl]methyl}piperazin-1-yl)-2-(1H-pyrrolo[2,3-b]pyridin-5-yloxy)benzamide; trans-4-(4-{[2-(4-chlorophenyl)-4,4-dimethylcyclohex-1-en-1-yl]methyl}piperazin-1-yl)-N-({4-[(4-methoxycyclohexyl)methoxy]-3-nitrophenyl}sulfonyl)-2-(1H-pyrrolo[2,3-b]pyridin-5-yloxy)benzamide; tert-butyl 4-{[4-({[4-(4-{[2-(4-chlorophenyl)-4,4-dimethylcyclohex-1-en-1-yl]methyl}piperazin-1-yl)-2-(1H-pyrrolo[2,3-b]pyridin-5-yloxy)benzoyl]amino}sulfonyl)-2-nitrophenoxy]methyl}-4-fluoropiperidine-1-carboxylate; 4-(4-{[2-(4-chlorophenyl)-4,4-dimethylcyclohex-1-en-1-yl]methyl}piperazin-1-yl)-N-({4-[(4-fluoropiperidin-4-yl)methoxy]-3-nitrophenyl}sulfonyl)-2-(1H-pyrrolo[2,3-b]pyridin-5-yloxy)benzamide; trans-4-(4-{[2-(4-chlorophenyl)-4,4-dimethylcyclohex-1-en-1-yl]methyl}piperazin-1-yl)-N-[(3-nitro-4-{[4-(4-tetrahydro-2H-pyran-4-ylpiperazin-1-yl)cyclohexyl]amino}phenyl)sulfonyl]-2-(1H-pyrrolo[2,3-b]pyridin-5-yloxy)benzamide; 4-(4-{[2-(4-chlorophenyl)-4,4-dimethylcyclohex-1-en-1-yl]methyl}piperazin-1-yl)-N-{[4-({1-[2-fluoro-1-(fluoromethyl)ethyl]piperidin-4-yl}methoxy)-3-nitrophenyl]sulfonyl}-2-(1H-pyrrolo[2,3-b]pyridin-5-yloxy)benzamide; 4-(4-{[2-(4-chlorophenyl)-4,4-dimethylcyclohex-1-en-1-yl]methyl}piperazin-1-yl)-N-[(3-nitro-4-{[(3R)-1-tetrahydro-2H-pyran-4-ylpyrrolidin-3-yl]amino}phenyl)sulfonyl]-2-(1H-pyrrolo[2,3-b]pyridin-5-yloxy)benzamide; 4-(4-{[2-(4-chlorophenyl)-4,4-dimethylcyclohex-1-en-1-yl]methyl}piperazin-1-yl)-N-[(4-{[(3R)-1-(2,2-dimethyltetrahydro-2H-pyran-4-yl)pyrrolidin-3-yl]amino}-3-nitrophenyl)sulfonyl]-2-(1H-pyrrolo[2,3-b]pyridin-5-yloxy)benzamide; 4-(4-{[2-(4-chlorophenyl)-4,4-dimethylcyclohex-1-en-1-yl]methyl}piperazin-1-yl)-N-[(3-nitro-4-{[(3S)-1-tetrahydro-2H-pyran-4-ylpyrrolidin-3-yl]amino}phenyl)sulfonyl]-2-(1H-pyrrolo[2,3-b]pyridin-5-yloxy)benzamide; 4-(4-{[2-(4-chlorophenyl)-4,4-dimethylcyclohex-1-en-1-yl]methyl}piperazin-1-yl)-N-[(4-{[(3S)-1-(2,2-dimethyltetrahydro-2H-pyran-4-yl)pyrrolidin-3-yl]amino}-3-nitrophenyl)sulfonyl]-2-(1H-pyrrolo[2,3-b]pyridin-5-yloxy)benzamide; 4-(4-{[2-(4-chlorophenyl)-4,4-dimethylcyclohex-1-en-1-yl]methyl}piperazin-1-yl)-N-[(4-{[(4-methylmorpholin-2-yl)methyl]amino}-3-nitrophenyl)sulfonyl]-2-(1H-pyrrolo[2,3-b]pyridin-5-yloxy)benzamide; 4-(4-{[2-(4-chlorophenyl)-4,4-dimethylcyclohex-1-en-1-yl]methyl}piperazin-1-yl)-N-{[4-({[4-(2-methoxyethyl)morpholin-2-yl]methyl}amino)-3-nitrophenyl]sulfonyl}-2-(1H-pyrrolo[2,3-b]pyridin-5-yloxy)benzamide; N-[(4-{[(4-acetylmorpholin-2-yl)methyl]amino}-3-nitrophenyl)sulfonyl]-4-(4-{[2-(4-chlorophenyl)-4,4-dimethylcyclohex-1-en-1-yl]methyl}piperazin-1-yl)-2-(1H-pyrrolo[2,3-b]pyridin-5-yloxy)benzamide; 4-(4-{[2-(4-chlorophenyl)-4,4-dimethylcyclohex-1-en-1-yl]methyl}piperazin-1-yl)-N-[(4-{[trans-4-(fluoromethyl)-1-oxetan-3-ylpyrrolidin-3-yl]methoxy}-3-nitrophenyl)sulfonyl]-2-(1H-pyrrolo[2,3-b]pyridin-5-yloxy)benzamide; 4-(4-{[2-(4-chlorophenyl)-4,4-dimethylcyclohex-1-en-1-yl]methyl}piperazin-1-yl)-N-[(4-{[(4-fluorotetrahydro-2H-pyran-4-yl)methyl]amino}-3-nitrophenyl)sulfonyl]-2-(1H-pyrrolo[2,3-b]pyridin-5-yloxy)benzamide; 4-(4-{[2-(4-chlorophenyl)-4,4-dimethylcyclohex-1-en-1-yl]methyl}piperazin-1-yl)-N-({3-nitro-4-[(1-oxetan-3-ylpiperidin-4-yl)amino]phenyl}sulfonyl)-2-(1H-pyrrolo[2,3-b]pyridin-5-yloxy)benzamide; 4-(4-{[2-(4-chlorophenyl)-4,4-dimethylcyclohex-1-en-1-yl]methyl}piperazin-1-yl)-N-({4-[(1-cyclobutylpiperidin-4-yl)amino]-3-nitrophenyl}sulfonyl)-2-(1H-pyrrolo[2,3-b]pyridin-5-yloxy)benzamide; 4-(4-{[2-(4-chlorophenyl)-4,4-dimethylcyclohex-1-en-1-yl]methyl}piperazin-1-yl)-N-[(4-{[1-(2,2-dimethyltetrahydro-2H-pyran-4-yl)piperidin-4-yl]amino}-3-nitrophenyl)sulfonyl]-2-(1H-pyrrolo[2,3-b]pyridin-5-yloxy)benzamide; 4-(4-{[2-(4-chlorophenyl)-4,4-dimethylcyclohex-1-en-1-yl]methyl}piperazin-1-yl)-N-[(4-{[(3S)-1-cyclopropylpyrrolidin-3-yl]amino}-3-nitrophenyl)sulfonyl]-2-(1H-pyrrolo[2,3-b]pyridin-5-yloxy)benzamide; 4-(4-{[2-(4-chlorophenyl)-4,4-dimethylcyclohex-1-en-1-yl]methyl}piperazin-1-yl)-N-({3-nitro-4-[(1-tetrahydrofuran-3-ylpiperidin-4-yl)amino]phenyl}sulfonyl)-2-(1H-pyrrolo[2,3-b]pyridin-5-yloxy)benzamide; 4-(4-{[2-(4-chlorophenyl)-4,4-dimethylcyclohex-1-en-1-yl]methyl}piperazin-1-yl)-N-[(4-{[(3R)-1-cyclopropylpyrrolidin-3-yl]amino}-3-nitrophenyl)sulfonyl]-2-(1H-pyrrolo[2,3-b]pyridin-5-yloxy)benzamide; 4-(4-{[2-(4-chlorophenyl)-4,4-dimethylcyclohex-1-en-1-yl]methyl}piperazin-1-yl)-N-{[3-nitro-4-({[(3S)-1-tetrahydro-2H-pyran-4-ylpyrrolidin-3-yl]methyl}amino)phenyl]sulfonyl}-2-(1H-pyrrolo[2,3-b]pyridin-5-yloxy)benzamide; 4-(4-{[2-(4-chlorophenyl)-4,4-dimethylcyclohex-1-en-1-yl]methyl}piperazin-1-yl)-N-({4-[(3-hydroxy-2,2-dimethylpropyl)amino]-3-nitrophenyl}sulfonyl)-2-(1H-pyrrolo[2,3-b]pyridin-5-yloxy)benzamide; 4-(4-{[2-(4-chlorophenyl)-4,4-dimethylcyclohex-1-en-1-yl]methyl}piperazin-1-yl)-N-{[4-({[1-(methylsulfonyl)piperidin-3-yl]methyl}amino)-3-nitrophenyl]sulfonyl}-2-(1H-pyrrolo[2,3-b]pyridin-5-yloxy)benzamide; N-[(4-{[(1-acetylpiperidin-3-yl)methyl]amino}-3-nitrophenyl)sulfonyl]-4-(4-{[2-(4-chlorophenyl)-4,4-dimethylcyclohex-1-en-1-yl]methyl}piperazin-1-yl)-2-(1H-pyrrolo[2,3-b]pyridin-5-yloxy)benzamide; 4-(4-{[2-(4-chlorophenyl)-4,4-dimethylcyclohex-1-en-1-yl]methyl}piperazin-1-yl)-N-[(4-{[(3R)-1-(methylsulfonyl)pyrrolidin-3-yl]amino}-3-nitrophenyl)sulfonyl]-2-(1H-pyrrolo[2,3-b]pyridin-5-yloxy)benzamide; 4-(4-{[2-(4-chlorophenyl)-3,3-dimethylcyclohex-1-en-1-yl]methyl}piperazin-1-yl)-N-({3-nitro-4-[(tetrahydro-2H-pyran-4-ylmethyl)amino]phenyl}sulfonyl)-2-(1H-pyrrolo[2,3-b]pyridin-5-yloxy)benzamide; 4-(4-{[2-(4-chlorophenyl)-4,4-dimethylcyclohex-1-en-1-yl]methyl}piperazin-1-yl)-N-{[4-({1-[2-fluoro-1-(fluoromethyl)ethyl]azetidin-3-yl}amino)-3-nitrophenyl]sulfonyl}-2-(1H-pyrrolo[2,3-b]pyridin-5-yloxy)benzamide; 4-(4-{[2-(4-chlorophenyl)-4,4-dimethylcyclohex-1-en-1-yl]methyl}piperazin-1-yl)-N-{[4-({[1-(methylsulfonyl)pyrrolidin-3-yl]methyl}amino)-3-nitrophenyl]sulfonyl}-2-(1H-pyrrolo[2,3-b]pyridin-5-yloxy)benzamide; N-[(4-{[(1-acetylpyrrolidin-3-yl)methyl]amino}-3-nitrophenyl)sulfonyl]-4-(4-{[2-(4-chlorophenyl)-4,4-dimethylcyclohex-1-en-1-yl]methyl}piperazin-1-yl)-2-(1H-pyrrolo[2,3-b]pyridin-5-yloxy)benzamide; N-[(4-{[(3R)-1-acetylpyrrolidin-3-yl]amino}-3-nitrophenyl)sulfonyl]-4-(4-{[2-(4-chlorophenyl)-4,4-dimethylcyclohex-1-en-1-yl]methyl}piperazin-1-yl)-2-(1H-pyrrolo[2,3-b]pyridin-5-yloxy)benzamide; 4-(4-{[2-(4-chlorophenyl)-4,4-dimethylcyclohex-1-en-1-yl]methyl}piperazin-1-yl)-N-({4-[(3-methoxy-2,2-dimethylpropyl)amino]-3-nitrophenyl}sulfonyl)-2-(1H-pyrrolo[2,3-b]pyridin-5-yloxy)benzamide; 4-(4-{[2-(4-chlorophenyl)-4,4-dimethylcyclohex-1-en-1-yl]methyl}piperazin-1-yl)-N-{[4-({[(1R,3R)-3-hydroxycyclopentyl]methyl}amino)-3-nitrophenyl]sulfonyl}-2-(1H-pyrrolo[2,3-b]pyridin-5-yloxy)benzamide; 4-(4-{[2-(4-chlorophenyl)-4,4-dimethylcyclohex-1-en-1-yl]methyl}piperazin-1-yl)-N-{[4-({[(1S,3S)-3-hydroxycyclopentyl]methyl}amino)-3-nitrophenyl]sulfonyl}-2-(1H-pyrrolo[2,3-b]pyridin-5-yloxy)benzamide; 4-(4-{[2-(4-chlorophenyl)-4,4-dimethylcyclohex-1-en-1-yl]methyl}piperazin-1-yl)-N-{[4-({[(1S,3R)-3-hydroxycyclopentyl]methyl}amino)-3-nitrophenyl]sulfonyl}-2-(1H-pyrrolo[2,3-b]pyridin-5-yloxy)benzamide; 4-(4-{[2-(4-chlorophenyl)-4,4-dimethylcyclohex-1-en-1-yl]methyl}piperazin-1-yl)-N-{[4-({[(1R,3S)-3-hydroxycyclopentyl]methyl}amino)-3-nitrophenyl]sulfonyl}-2-(1H-pyrrolo[2,3-b]pyridin-5-yloxy)benzamide; 4-(4-{[2-(4-chlorophenyl)-4,4-dimethylcyclohex-1-en-1-yl]methyl}piperazin-1-yl)-N-[(3-nitro-4-{[(3S)-2-oxopiperidin-3-yl]amino}phenyl)sulfonyl]-2-(1H-pyrrolo[2,3-b]pyridin-5-yloxy)benzamide; 4-(4-{[2-(4-chlorophenyl)-4,4-dimethylcyclohex-1-en-1-yl]methyl}piperazin-1-yl)-N-({4-[({1-[2-fluoro-1-(fluoromethyl)ethyl]azetidin-3-yl}methyl)amino]-3-nitrophenyl}sulfonyl)-2-(1H-pyrrolo[2,3-b]pyridin-5-yloxy)benzamide; 4-(4-{[2-(4-chlorophenyl)-4,4-dimethylcyclohex-1-en-1-yl]methyl}piperazin-1-yl)-N-[(3-nitro-4-{[(1-oxetan-3-ylazetidin-3-yl)methyl]amino}phenyl)sulfonyl]-2-(1H-pyrrolo[2,3-b]pyridin-5-yloxy)benzamide; 4-(4-{[2-(4-chlorophenyl)-4,4-dimethylcyclohex-1-en-1-yl]methyl}piperazin-1-yl)-N-[(3-nitro-4-{[(1-oxetan-3-ylpiperidin-4-yl)methyl]amino}phenyl)sulfonyl]-2-(1H-pyrrolo[2,3-b]pyridin-5-yloxy)benzamide; 4-(4-{[2-(4-chlorophenyl)-4,4-dimethylcyclohex-1-en-1-yl]methyl}piperazin-1-yl)-N-[(4-{[(1-cyclopropylpiperidin-4-yl)methyl]amino}-3-nitrophenyl)sulfonyl]-2-(1H-pyrrolo[2,3-b]pyridin-5-yloxy)benzamide; 4-(4-{[2-(4-chlorophenyl)-4,4-dimethylcyclohex-1-en-1-yl]methyl}piperazin-1-yl)-N-{[4-({[4-(2-fluoroethyl)morpholin-2-yl]methyl}amino)-3-nitrophenyl]sulfonyl}-2-(1H-pyrrolo[2,3-b]pyridin-5-yloxy)benzamide; 4-(4-{[2-(4-chlorophenyl)-4,4-dimethylcyclohex-1-en-1-yl]methyl}piperazin-1-yl)-N-{[4-({[4-(2,2-difluoroethyl)morpholin-2-yl]methyl}amino)-3-nitrophenyl]sulfonyl}-2-(1H-pyrrolo[2,3-b]pyridin-5-yloxy)benzamide; 4-(4-{[2-(4-chlorophenyl)-4,4-dimethylcyclohex-1-en-1-yl]methyl}piperazin-1-yl)-N-({4-[(4-fluoro-1-oxetan-3-ylpiperidin-4-yl)methoxy]-3-nitrophenyl}sulfonyl)-2-(1H-pyrrolo[2,3-b]pyridin-5-yloxy)benzamide; 4-(4-{[2-(4-chlorophenyl)-4,4-dimethylcyclohex-1-en-1-yl]methyl}piperazin-1-yl)-N-[(4-{[(2S)-4,4-difluoro-1-oxetan-3-ylpyrrolidin-2-yl]methoxy}-3-nitrophenyl)sulfonyl]-2-(1H-pyrrolo[2,3-b]pyridin-5-yloxy)benzamide; 4-(4-{[2-(4-chlorophenyl)-4,4-dimethylcyclohex-1-en-1-yl]methyl}piperazin-1-yl)-N-[(3-nitro-4-{[(4-tetrahydro-2H-pyran-4-ylmorpholin-3-yl)methyl]amino}phenyl)sulfonyl]-2-(1H-pyrrolo[2,3-b]pyridin-5-yloxy)benzamide; 4-(4-{[2-(4-chlorophenyl)-4,4-dimethylcyclohex-1-en-1-yl]methyl}piperazin-1-yl)-N-[(4-{[(4-cyclobutylmorpholin-3-yl)methyl]amino}-3-nitrophenyl)sulfonyl]-2-(1H-pyrrolo[2,3-b]pyridin-5-yloxy)benzamide; 4-(4-{[2-(4-chlorophenyl)-4,4-dimethylcyclohex-1-en-1-yl]methyl}piperazin-1-yl)-N-[(3-nitro-4-{[(4-tetrahydrofuran-3-ylmorpholin-3-yl)methyl]amino}phenyl)sulfonyl]-2-(1H-pyrrolo[2,3-b]pyridin-5-yloxy)benzamide; 4-(4-{[2-(4-chlorophenyl)-4,4-dimethylcyclohex-1-en-1-yl]methyl}piperazin-1-yl)-N-({4-[({1-[2-fluoro-1-(fluoromethyl)ethyl]piperidin-4-yl}methyl)amino]-3-nitrophenyl}sulfonyl)-2-(1H-pyrrolo[2,3-b]pyridin-5-yloxy)benzamide; 4-(4-{[2-(4-chlorophenyl)-4,4-dimethylcyclohex-1-en-1-yl]methyl}piperazin-1-yl)-N-({4-[(1-cyclopropyl-4-fluoropiperidin-4-yl)methoxy]-3-nitrophenyl}sulfonyl)-2-(1H-pyrrolo[2,3-b]pyridin-5-yloxy)benzamide; 4-(4-{[2-(4-chlorophenyl)-4,4-dimethylcyclohex-1-en-1-yl]methyl}piperazin-1-yl)-N-({4-[(4-methoxybenzyl)amino]-3-nitrophenyl}sulfonyl)-2-(1H-pyrrolo[2,3-b]pyridin-5-yloxy)benzamide; 4-(4-{[2-(4-chlorophenyl)-4,4-dimethylcyclohex-1-en-1-yl]methyl}piperazin-1-yl)-N-[(3-nitro-4-{[3-(trifluoromethoxy)benzyl]amino}phenyl)sulfonyl]-2-(1H-pyrrolo[2,3-b]pyridin-5-yloxy)benzamide; 4-(4-{[2-(4-chlorophenyl)-4,4-dimethylcyclohex-1-en-1-yl]methyl}piperazin-1-yl)-N-({4-[(3-methoxybenzyl)amino]-3-nitrophenyl}sulfonyl)-2-(1H-pyrrolo[2,3-b]pyridin-5-yloxy)benzamide; 4-(4-{[2-(4-chlorophenyl)-4,4-dimethylcyclohex-1-en-1-yl]methyl}piperazin-1-yl)-N-[(4-{[4-(difluoromethoxy)benzyl]amino}-3-nitrophenyl)sulfonyl]-2-(1H-pyrrolo[2,3-b]pyridin-5-yloxy)benzamide; 4-(4-{[2-(4-chlorophenyl)-4,4-dimethylcyclohex-1-en-1-yl]methyl}piperazin-1-yl)-N-{[4-(1,4-dioxaspiro[4.5]dec-8-ylamino)-3-nitrophenyl]sulfonyl}-2-(1H-pyrrolo[2,3-b]pyridin-5-yloxy)benzamide; trans-N-[(4-{[4-(acetylamino)cyclohexyl]amino}-3-nitrophenyl)sulfonyl]-4-(4-{[2-(4-chlorophenyl)-4,4-dimethylcyclohex-1-en-1-yl]methyl}piperazin-1-yl)-2-(1H-pyrrolo[2,3-b]pyridin-5-yloxy)benzamide; 4-(4-{[2-(4-chlorophenyl)-4,4-dimethylcyclohex-1-en-1-yl]methyl}piperazin-1-yl)-N-[(4-{[(3R)-1-(2,2-difluoroethyl)pyrrolidin-3-yl]amino}-3-nitrophenyl)sulfonyl]-2-(1H-pyrrolo[2,3-b]pyridin-5-yloxy)benzamide; 4-(4-{[2-(4-chlorophenyl)-4,4-dimethylcyclohex-1-en-1-yl]methyl}piperazin-1-yl)-N-[(4-{[(3S)-1-(2-fluoroethyl)pyrrolidin-3-yl]amino}-3-nitrophenyl)sulfonyl]-2-(1H-pyrrolo[2,3-b]pyridin-5-yloxy)benzamide; 4-(4-{[2-(4-chlorophenyl)-4,4-dimethylcyclohex-1-en-1-yl]methyl}piperazin-1-yl)-N-[(4-{[(3S)-1-(2,2-difluoroethyl)pyrrolidin-3-yl]amino}-3-nitrophenyl)sulfonyl]-2-(1H-pyrrolo[2,3-b]pyridin-5-yloxy)benzamide; 4-(4-{[2-(4-chlorophenyl)-4,4-dimethylcyclohex-1-en-1-yl]methyl}piperazin-1-yl)-N-[(4-{[(3R)-1-(2-fluoroethyl)pyrrolidin-3-yl]amino}-3-nitrophenyl)sulfonyl]-2-(1H-pyrrolo[2,3-b]pyridin-5-yloxy)benzamide; 4-(4-{[2-(4-chlorophenyl)-4,4-dimethylcyclohex-1-en-1-yl]methyl}piperazin-1-yl)-N-[(3-nitro-4-{[(3S)-1-oxetan-3-ylpyrrolidin-3-yl]methoxy}phenyl)sulfonyl]-2-(1H-pyrrolo[2,3-b]pyridin-5-yloxy)benzamide; 4-(4-{[2-(4-chlorophenyl)-4,4-dimethylcyclohex-1-en-1-yl]methyl}piperazin-1-yl)-N-({4-[(4-hydroxybenzyl)amino]-3-nitrophenyl}sulfonyl)-2-(1H-pyrrolo[2,3-b]pyridin-5-yloxy)benzamide; 4-(4-{[2-(4-chlorophenyl)-4,4-dimethylcyclohex-1-en-1-yl]methyl}piperazin-1-yl)-N-({4-[(3-hydroxybenzyl)amino]-3-nitrophenyl}sulfonyl)-2-(1H-pyrrolo[2,3-b]pyridin-5-yloxy)benzamide; 4-(4-{[2-(4-chlorophenyl)-4,4-dimethylcyclohex-1-en-1-yl]methyl}piperazin-1-yl)-N-[(4-{[3-(difluoromethoxy)benzyl]amino}-3-nitrophenyl)sulfonyl]-2-(1H-pyrrolo[2,3-b]pyridin-5-yloxy)benzamide; 4-(4-{[2-(4-chlorophenyl)-4,4-dimethylcyclohex-1-en-1-yl]methyl}piperazin-1-yl)-N-{[4-({[cis-3-morpholin-4-ylcyclopentyl]methyl}amino)-3-nitrophenyl]sulfonyl}-2-(1H-pyrrolo[2,3-b]pyridin-5-yloxy)benzamide; trans-4-(4-{[2-(4-chlorophenyl)-4,4-dimethylcyclohex-1-en-1-yl]methyl}piperazin-1-yl)-N-{[4-({4-[(methylsulfonyl)amino]cyclohexyl}amino)-3-nitrophenyl]sulfonyl}-2-(1H-pyrrolo[2,3-b]pyridin-5-yloxy)benzamide; 4-(4-{[2-(4-chlorophenyl)-4,4-dimethylcyclohex-1-en-1-yl]methyl}piperazin-1-yl)-N-({4-[(1-cyclopropylpiperidin-4-yl)amino]-3-[(trifluoromethyl)sulfonyl]phenyl}sulfonyl)-2-(1H-pyrrolo[2,3-b]pyridin-5-yloxy)benzamide; 4-(4-{[2-(4-chlorophenyl)-4,4-dimethylcyclohex-1-en-1-yl]methyl}piperazin-1-yl)-N-({3-nitro-4-[(1-oxetan-3-ylpiperidin-4-yl)methoxy]phenyl}sulfonyl)-2-(1H-pyrrolo[2,3-b]pyridin-5-yloxy)benzamide; 4-(4-{[2-(4-chlorophenyl)-4,4-dimethylcyclohex-1-en-1-yl]methyl}piperazin-1-yl)-N-({4-[(4-fluoro-1-tetrahydro-2H-pyran-4-ylpiperidin-4-yl)methoxy]-3-nitrophenyl}sulfonyl)-2-(1H-pyrrolo[2,3-b]pyridin-5-yloxy)benzamide; 4-(4-{[2-(4-chlorophenyl)-4,4-dimethylcyclohex-1-en-1-yl]methyl}piperazin-1-yl)-N-({4-[(4-fluoro-1-tetrahydrofuran-3-ylpiperidin-4-yl)methoxy]-3-nitrophenyl}sulfonyl)-2-(1H-pyrrolo[2,3-b]pyridin-5-yloxy)benzamide; 4-(4-{[2-(4-chlorophenyl)-4,4-dimethylcyclohex-1-en-1-yl]methyl}piperazin-1-yl)-N-[(4-{[4-fluoro-1-(methylsulfonyl)piperidin-4-yl]methoxy}-3-nitrophenyl)sulfonyl]-2-(1H-pyrrolo[2,3-b]pyridin-5-yloxy)benzamide; 4-(4-{[2-(4-chlorophenyl)-4,4-dimethylcyclohex-1-en-1-yl]methyl}piperazin-1-yl)-N-{[3-nitro-4-({[(3R)-1-oxetan-3-ylpyrrolidin-3-yl]methyl}amino)phenyl]sulfonyl}-2-(1H-pyrrolo[2,3-b]pyridin-5-yloxy)benzamide; trans-4-(4-{[2-(4-chlorophenyl)-4,4-dimethylcyclohex-1-en-1-yl]methyl}piperazin-1-yl)-N-({4-[(4-hydroxycyclohexyl)methoxy]-3-nitrophenyl}sulfonyl)-2-(1H-pyrrolo[2,3-b]pyridin-5-yloxy)benzamide; 4-(4-{[2-(4-chlorophenyl)-4,4-dimethylcyclohex-1-en-1-yl]methyl}piperazin-1-yl)-N-{[4-({4-[3-(dimethylamino)propoxy]benzyl}amino)-3-nitrophenyl]sulfonyl}-2-(1H-pyrrolo[2,3-b]pyridin-5-yloxy)benzamide; 4-(4-{[2-(4-chlorophenyl)-4,4-dimethylcyclohex-1-en-1-yl]methyl}piperazin-1-yl)-N-[(4-{[4-(2-morpholin-4-ylethoxy)benzyl]amino}-3-nitrophenyl)sulfonyl]-2-(1H-pyrrolo[2,3-b]pyridin-5-yloxy)benzamide; 4-(4-{[2-(4-chlorophenyl)-4,4-dimethylcyclohex-1-en-1-yl]methyl}piperazin-1-yl)-N-{[4-({[(E)-4-hydroxy-1-adamantyl]methyl}amino)-3-nitrophenyl]sulfonyl}-2-(1H-pyrrolo[2,3-b]pyridin-5-yloxy)benzamide; 4-(4-{[2-(4-chlorophenyl)-4,4-dimethylcyclohex-1-en-1-yl]methyl}piperazin-1-yl)-N-{[4-({[(Z)-4-hydroxy-1-adamantyl]methyl}amino)-3-nitrophenyl]sulfonyl}-2-(1H-pyrrolo[2,3-b]pyridin-5-yloxy)benzamide; N-({4-[(1S,4S)-bicyclo[2.2.1]hept-5-en-2-ylmethoxy]-3-nitrophenyl}sulfonyl)-4-(4-{[2-(4-chlorophenyl)-4,4-dimethylcyclohex-1-en-1-yl]methyl}piperazin-1-yl)-2-(1H-pyrrolo[2,3-b]pyridin-5-yloxy)benzamide; 4-(4-{[2-(4-chlorophenyl)-4,4-dimethylcyclohex-1-en-1-yl]methyl}piperazin-1-yl)-N-({4-[(1-methyl-5-oxopyrrolidin-3-yl)amino]-3-nitrophenyl}sulfonyl)-2-(1H-pyrrolo[2,3-b]pyridin-5-yloxy)benzamide; 4-(4-{[2-(4-chlorophenyl)-4,4-dimethylcyclohex-1-en-1-yl]methyl}piperazin-1-yl)-N-[(4-{[(1R,4R,5R,6S)-5,6-dihydroxybicyclo[2.2.1]hept-2-yl]methoxy}-3-nitrophenyl)sulfonyl]-2-(1H-pyrrolo[2,3-b]pyridin-5-yloxy)benzamide; 4-(4-{[2-(4-chlorophenyl)-4,4-dimethylcyclohex-1-en-1-yl]methyl}piperazin-1-yl)-N-[(4-{[(1R,4R,5S,6R)-5,6-dihydroxybicyclo[2.2.1]hept-2-yl]methoxy}-3-nitrophenyl)sulfonyl]-2-(1H-pyrrolo[2,3-b]pyridin-5-yloxy)benzamide; 4-(4-{[2-(4-chlorophenyl)-4,4-dimethylcyclohex-1-en-1-yl]methyl}piperazin-1-yl)-N-({3-nitro-4-[(3-oxocyclohexyl)methoxy]phenyl}sulfonyl)-2-(1H-pyrrolo[2,3-b]pyridin-5-yloxy)benzamide; 4-(4-{[2-(4-chlorophenyl)-5,5-dimethylcyclohexa-1,3-dien-1-yl]methyl}piperazin-1-yl)-N-({3-nitro-4-[(tetrahydro-2H-pyran-4-ylmethyl)amino]phenyl}sulfonyl)-2-(1H-pyrrolo[2,3-b]pyridin-5-yloxy)benzamide; 4-(4-{[2-(4-chlorophenyl)-4,4-dimethylcyclohex-1-en-1-yl]methyl}piperazin-1-yl)-N-{[4-({(3R)-1-[2-fluoro-1-(fluoromethyl)ethyl]pyrrolidin-3-yl}amino)-3-nitrophenyl]sulfonyl}-2-(1H-pyrrolo[2,3-b]pyridin-5-yloxy)benzamide; 4-(4-{[2-(4-chlorophenyl)-4,4-dimethylcyclohex-1-en-1-yl]methyl}piperazin-1-yl)-N-{[6-[(4-fluorotetrahydro-2H-pyran-4-yl)methoxy]-5-(trifluoromethyl)pyridin-3-yl]sulfonyl}-2-(1H-pyrrolo[2,3-b]pyridin-5-yloxy)benzamide; 4-(4-{[2-(4-chlorophenyl)-4,4-dimethylcyclohex-1-en-1-yl]methyl}piperazin-1-yl)-N-{[3-nitro-4-({[(3S)-1-oxetan-3-ylpyrrolidin-3-yl]methyl}amino)phenyl]sulfonyl}-2-(1H-pyrrolo[2,3-b]pyridin-5-yloxy)benzamide; trans-N-({5-chloro-6-[(4-methoxycyclohexyl)methoxy]pyridin-3-yl}sulfonyl)-4-(4-{[2-(4-chlorophenyl)-4,4-dimethylcyclohex-1-en-1-yl]methyl}piperazin-1-yl)-2-(1H-pyrrolo[2,3-b]pyridin-5-yloxy)benzamide; cis-N-({5-chloro-6-[(4-methoxycyclohexyl)methoxy]pyridin-3-yl}sulfonyl)-4-(4-{[2-(4-chlorophenyl)-4,4-dimethylcyclohex-1-en-1-yl]methyl}piperazin-1-yl)-2-(1H-pyrrolo[2,3-b]pyridin-5-yloxy)benzamide; 4-(4-{[2-(4-chlorophenyl)-4,4-dimethylcyclohex-1-en-1-yl]methyl}piperazin-1-yl)-N-[(3-nitro-4-{[(3S)-1-oxetan-3-ylpyrrolidin-3-yl]amino}phenyl)sulfonyl]-2-(1H-pyrrolo[2,3-b]pyridin-5-yloxy)benzamide; 4-(4-{[2-(4-chlorophenyl)-4,4-dimethylcyclohex-1-en-1-yl]methyl}piperazin-1-yl)-N-({4-[({4-[2-(2-methoxyethoxy)ethyl]morpholin-2-yl}methyl)amino]-3-nitrophenyl}sulfonyl)-2-(1H-pyrrolo[2,3-b]pyridin-5-yloxy)benzamide; 4-(4-{[2-(4-chlorophenyl)-4,4-dimethylcyclohex-1-en-1-yl]methyl}piperazin-1-yl)-N-{[4-({[4-(cyanomethyl)morpholin-2-yl]methyl}amino)-3-nitrophenyl]sulfonyl}-2-(1H-pyrrolo[2,3-b]pyridin-5-yloxy)benzamide; 4-(4-{[2-(4-chlorophenyl)-4,4-dimethylcyclohex-1-en-1-yl]methyl}piperazin-1-yl)-N-{[4-({[4-(N,N-dimethylglycyl)morpholin-2-yl]methyl}amino)-3-nitrophenyl]sulfonyl}-2-(1H-pyrrolo[2,3-b]pyridin-5-yloxy)benzamide; (2-{[(4-{[4-(4-{[2-(4-chlorophenyl)-4,4-dimethylcyclohex-1-en-1-yl]methyl}piperazin-1-yl)-2-(1H-pyrrolo[2,3-b]pyridin-5-yloxy)benzoyl]sulfamoyl}-2-nitrophenyl)amino]methyl}morpholin-4-yl)acetic acid; 4-(4-{[2-(4-chlorophenyl)-4,4-dimethylcyclohex-1-en-1-yl]methyl}piperazin-1-yl)-N-{[3-nitro-4-({[4-(oxetan-3-yl)morpholin-2-yl]methyl}amino)phenyl]sulfonyl}-2-(1H-pyrrolo[2,3-b]pyridin-5-yloxy)benzamide; 4-(4-{[2-(4-chlorophenyl)-4,4-dimethylcyclohex-1-en-1-yl]methyl}piperazin-1-yl)-N-[(4-{[(4-cyclopropylmorpholin-2-yl)methyl]amino}-3-nitrophenyl)sulfonyl]-2-(1H-pyrrolo[2,3-b]pyridin-5-yloxy)benzamide; 4-(4-{[2-(4-chlorophenyl)-4,4-dimethylcyclohex-1-en-1-yl]methyl}piperazin-1-yl)-N-{[5-(methylsulfonyl)-6-(tetrahydro-2H-pyran-4-ylmethoxy)pyridin-3-yl]sulfonyl}-2-(1H-pyrrolo[2,3-b]pyridin-5-yloxy)benzamide; 4-(4-{[2-(4-chlorophenyl)-4,4-dimethylcyclohex-1-en-1-yl]methyl}piperazin-1-yl)-N-({4-[(4-fluorotetrahydro-2H-pyran-4-yl)methoxy]-3-[(trifluoromethyl)sulfonyl]phenyl}sulfonyl)-2-(1H-pyrrolo[2,3-b]pyridin-5-yloxy)benzamide; 4-(4-{[2-(4-chlorophenyl)-4,4-dimethylcyclohex-1-en-1-yl]methyl}piperazin-1-yl)-N-({4-[(4-methyltetrahydro-2H-pyran-4-yl)methoxy]-3-nitrophenyl}sulfonyl)-2-(1H-pyrrolo[2,3-b]pyridin-5-yloxy)benzamide; Ethyl 4-(4-{[4-(4-{[2-(4-chlorophenyl)-4,4-dimethylcyclohex-1-en-1-yl]methyl}piperazin-1-yl)-2-(1H-pyrrolo[2,3-b]pyridin-5-yloxy)benzoyl]sulfamoyl}-2-nitrophenyl)piperazine-1-carboxylate; 4-(4-{[2-(4-chlorophenyl)-4,4-dimethylcyclohex-1-en-1-yl]methyl}piperazin-1-yl)-N-({4-[4-(morpholin-4-yl)piperidin-1-yl]-3-nitrophenyl}sulfonyl)-2-(1H-pyrrolo[2,3-b]pyridin-5-yloxy)benzamide; 4-(4-{[2-(4-chlorophenyl)-4,4-dimethylcyclohex-1-en-1-yl]methyl}piperazin-1-yl)-N-[(3-nitro-4-{[(3R)-1-(oxetan-3-yl)pyrrolidin-3-yl]amino}phenyl)sulfonyl]-2-(1H-pyrrolo[2,3-b]pyridin-5-yloxy)benzamide; 4-(4-{[2-(4-chlorophenyl)-4,4-dimethylcyclohex-1-en-1-yl]methyl}piperazin-1-yl)-N-[(4-{[(3R)-1-(1,3-difluoropropan-2-yl)pyrrolidin-3-yl]amino}-3-[(trifluoromethyl)sulfonyl]phenyl)sulfonyl]-2-(1H-pyrrolo[2,3-b]pyridin-5-yloxy)benzamide; 4-(4-{[2-(4-chlorophenyl)-4,4-dimethylcyclohex-1-en-1-yl]methyl}piperazin-1-yl)-N-({4-[(1-isopropylpiperidin-4-yl)amino]-3-nitrophenyl}sulfonyl)-2-(1H-pyrrolo[2,3-b]pyridin-5-yloxy)benzamide; N-({4-[(1-tert-butylpiperidin-4-yl)amino]-3-nitrophenyl}sulfonyl)-4-(4-{[2-(4-chlorophenyl)-4,4-dimethylcyclohex-1-en-1-yl]methyl}piperazin-1-yl)-2-(1H-pyrrolo[2,3-b]pyridin-5-yloxy)benzamide; 4-(4-{[2-(4-chlorophenyl)-4,4-dimethylcyclohex-1-en-1-yl]methyl}piperazin-1-yl)-N-{[4-({[1-(2-methoxyethyl)piperidin-3-yl]methyl}amino)-3-nitrophenyl]sulfonyl}-2-(1H-pyrrolo[2,3-b]pyridin-5-yloxy)benzamide; 4-(4-{[2-(4-chlorophenyl)-4,4-dimethylcyclohex-1-en-1-yl]methyl}piperazin-1-yl)-N-{[4-({[1-(cyanomethyl)piperidin-3-yl]methyl}amino)-3-nitrophenyl]sulfonyl}-2-(1H-pyrrolo[2,3-b]pyridin-5-yloxy)benzamide; 4-(4-{[2-(4-chlorophenyl)-4,4-dimethylcyclohex-1-en-1-yl]methyl}piperazin-1-yl)-N-({4-[(4-fluoro-1-methylpiperidin-4-yl)methoxy]-3-[(trifluoromethyl)sulfonyl]phenyl}sulfonyl)-2-(1H-pyrrolo[2,3-b]pyridin-5-yloxy)benzamide; N-[(5-chloro-6-{[(3R)-1-(1,3-difluoropropan-2-yl)pyrrolidin-3-yl]amino}pyridin-3-yl)sulfonyl]-4-(4-{[2-(4-chlorophenyl)-4,4-dimethylcyclohex-1-en-1-yl]methyl}piperazin-1-yl)-2-(1H-pyrrolo[2,3-b]pyridin-5-yloxy)benzamide; tert-butyl 4-[(4-{[4-(4-{[2-(4-chlorophenyl)-4,4-dimethylcyclohex-1-en-1-yl]methyl}piperazin-1-yl)-2-(1H-pyrrolo[2,3-b]pyridin-5-yloxy)benzoyl]sulfamoyl}-2-nitrophenyl)amino]piperazine-1-carboxylate; 4-(4-{[2-(4-chlorophenyl)-4,4-dimethylcyclohex-1-en-1-yl]methyl}piperazin-1-yl)-N-({3-(pentafluoro-λ ６ -sulfanyl)-4-[(tetrahydro-2H-pyran-4-ylmethyl)amino]phenyl}sulfonyl)-2-(1H-pyrrolo[2,3-b]pyridin-5-yloxy)benzamide; 4-(4-{[2-(4-chlorophenyl)-4,4-dimethylcyclohex-1-en-1-yl]methyl}piperazin-1-yl)-N-({4-[(4-methoxytetrahydro-2H-pyran-4-yl)methoxy]-3-nitrophenyl}sulfonyl)-2-(1H-pyrrolo[2,3-b]pyridin-5-yloxy)benzamide; 4-(4-{[2-(4-chlorophenyl)-4,4-dimethylcyclohex-1-en-1-yl]methyl}piperazin-1-yl)-N-[(4-{[(3R)-1-(1,3-difluoropropan-2-yl)pyrrolidin-3-yl]oxy}-3-nitrophenyl)sulfonyl]-2-(1H-pyrrolo[2,3-b]pyridin-5-yloxy)benzamide; 4-(4-{[2-(4-chlorophenyl)-4,4-dimethylcyclohex-1-en-1-yl]methyl}piperazin-1-yl)-N-[(3-nitro-4-{[4-(oxetan-3-yl)piperazin-1-yl]amino}phenyl)sulfonyl]-2-(1H-pyrrolo[2,3-b]pyridin-5-yloxy)benzamide; 4-(4-{[2-(4-chlorophenyl)-4,4-dimethylcyclohex-1-en-1-yl]methyl}piperazin-1-yl)-N-[(3-nitro-4-{[4-(tetrahydro-2H-pyran-4-yl)piperazin-1-yl]amino}phenyl)sulfonyl]-2-(1H-pyrrolo[2,3-b]pyridin-5-yloxy)benzamide; 4-(4-{[2-(4-chlorophenyl)-4,4-dimethylcyclohex-1-en-1-yl]methyl}piperazin-1-yl)-N-({3-nitro-4-[(3R)-tetrahydrofuran-3-ylamino]phenyl}sulfonyl)-2-(1H-pyrrolo[2,3-b]pyridin-5-yloxy)benzamide; 4-(4-{[2-(4-chlorophenyl)-4,4-dimethylcyclohex-1-en-1-yl]methyl}piperazin-1-yl)-N-[(4-{[(4,4-difluorocyclohexyl)methyl]amino}-3-nitrophenyl)sulfonyl]-2-(1H-pyrrolo[2,3-b]pyridin-5-yloxy)benzamide; N-({4-[(1-tert-butylpiperidin-4-yl)amino]-3-[(trifluoromethyl)sulfonyl]phenyl}sulfonyl)-4-(4-{[2-(4-chlorophenyl)-4,4-dimethylcyclohex-1-en-1-yl]methyl}piperazin-1-yl)-2-(1H-pyrrolo[2,3-b]pyridin-5-yloxy)benzamide; 4-(4-{[2-(4-chlorophenyl)-4,4-dimethylcyclohex-1-en-1-yl]methyl}piperazin-1-yl)-N-({4-({[4-(oxetan-3-yl)morpholin-2-yl]methyl}amino)-3-[(trifluoromethyl)sulfonyl]phenyl}sulfonyl)-2-(1H-pyrrolo[2,3-b]pyridin-5-yloxy)benzamide; N-[(5-chloro-6-{[(4-fluorotetrahydro-2H-pyran-4-yl)methyl]amino}pyridin-3-yl)sulfonyl]-4-(4-{[2-(4-chlorophenyl)-4,4-dimethylcyclohex-1-en-1-yl]methyl}piperazin-1-yl)-2-(1H-pyrrolo[2,3-b]pyridin-5-yloxy)benzamide; N-({5-chloro-6-[(1-cyclopropylpiperidin-4-yl)amino]pyridin-3-yl}sulfonyl)-4-(4-{[2-(4-chlorophenyl)-4,4-dimethylcyclohex-1-en-1-yl]methyl}piperazin-1-yl)-2-(1H-pyrrolo[2,3-b]pyridin-5-yloxy)benzamide; N-[(5-chloro-6-{[(2S)-4-(cyanomethyl)morpholin-2-yl]methoxy}pyridin-3-yl)sulfonyl]-4-(4-{[2-(4-chlorophenyl)-4,4-dimethylcyclohex-1-en-1-yl]methyl}piperazin-1-yl)-2-(1H-pyrrolo[2,3-b]pyridin-5-yloxy)benzamide; N-[(5-chloro-6-{[(2S)-4-(N,N-dimethylglycyl)morpholin-2-yl]methoxy}pyridin-3-yl)sulfonyl]-4-(4-{[2-(4-chlorophenyl)-4,4-dimethylcyclohex-1-en-1-yl]methyl}piperazin-1-yl)-2-(1H-pyrrolo[2,3-b]pyridin-5-yloxy)benzamide; N-[(5-chloro-6-{[(2R)-4-(cyanomethyl)morpholin-2-yl]methoxy}pyridin-3-yl)sulfonyl]-4-(4-{[2-(4-chlorophenyl)-4,4-dimethylcyclohex-1-en-1-yl]methyl}piperazin-1-yl)-2-(1H-pyrrolo[2,3-b]pyridin-5-yloxy)benzamide; N-[(5-chloro-6-{[(2R)-4-(N,N-dimethylglycyl)morpholin-2-yl]methoxy}pyridin-3-yl)sulfonyl]-4-(4-{[2-(4-chlorophenyl)-4,4-dimethylcyclohex-1-en-1-yl]methyl}piperazin-1-yl)-2-(1H-pyrrolo[2,3-b]pyridin-5-yloxy)benzamide; 4-(4-{[2-(4-chlorophenyl)-4,4-dimethylcyclohex-1-en-1-yl]methyl}piperazin-1-yl)-N-({5-fluoro-6-[(4-fluorotetrahydro-2H-pyran-4-yl)methoxy]pyridin-3-yl}sulfonyl)-2-(1H-pyrrolo[2,3-b]pyridin-5-yloxy)benzamide; N-({5-chloro-6-[3-hydroxy-2-(hydroxymethyl)-2-methylpropoxy]pyridin-3-yl}sulfonyl)-4-(4-{[2-(4-chlorophenyl)-4,4-dimethylcyclohex-1-en-1-yl]methyl}piperazin-1-yl)-2-(1H-pyrrolo[2,3-b]pyridin-5-yloxy)benzamide; 4-(4-{[2-(4-chlorophenyl)-4,4-dimethylcyclohex-1-en-1-yl]methyl}piperazin-1-yl)-N-({6-[(4-fluorotetrahydro-2H-pyran-4-yl)methoxy]pyridin-3-yl}sulfonyl)-2-(1H-pyrrolo[2,3-b]pyridin-5-yloxy)benzamide; 4-(4-{[2-(4-chlorophenyl)-4,4-dimethylcyclohex-1-en-1-yl]methyl}piperazin-1-yl)-N-{[4-({[4-(1,3-difluoropropan-2-yl)morpholin-2-yl]methyl}amino)-3-nitrophenyl]sulfonyl}-2-(1H-pyrrolo[2,3-b]pyridin-5-yloxy)benzamide; N-[(5-chloro-6-{[1-(cyanomethyl)piperidin-4-yl]methoxy}pyridin-3-yl)sulfonyl]-4-(4-{[2-(4-chlorophenyl)-4,4-dimethylcyclohex-1-en-1-yl]methyl}piperazin-1-yl)-2-(1H-pyrrolo[2,3-b]pyridin-5-yloxy)benzamide; 4-(4-{[2-(4-chlorophenyl)-4,4-dimethylcyclohex-1-en-1-yl]methyl}piperazin-1-yl)-N-{[4-({(3R)-1-[2-(2-methoxyethoxy)ethyl]pyrrolidin-3-yl}amino)-3-nitrophenyl]sulfonyl}-2-(1H-pyrrolo[2,3-b]pyridin-5-yloxy)benzamide; 4-(4-{[2-(4-chlorophenyl)-4,4-dimethylcyclohex-1-en-1-yl]methyl}piperazin-1-yl)-N-[(4-{[(3R)-1-(N,N-dimethylglycyl)pyrrolidin-3-yl]amino}-3-nitrophenyl)sulfonyl]-2-(1H-pyrrolo[2,3-b]pyridin-5-yloxy)benzamide; 4-(4-{[2-(4-chlorophenyl)-4,4-dimethylcyclohex-1-en-1-yl]methyl}piperazin-1-yl)-N-[(3-nitro-4-{[1-(oxetan-3-yl)azetidin-3-yl]amino}phenyl)sulfonyl]-2-(1H-pyrrolo[2,3-b]pyridin-5-yloxy)benzamide; N-[(5-chloro-6-{[1-(cyanomethyl)-4-fluoropiperidin-4-yl]methoxy}pyridin-3-yl)sulfonyl]-4-(4-{[2-(4-chlorophenyl)-4,4-dimethylcyclohex-1-en-1-yl]methyl}piperazin-1-yl)-2-(1H-pyrrolo[2,3-b]pyridin-5-yloxy)benzamide; 4-(4-{[2-(4-chlorophenyl)-4,4-dimethylcyclohex-1-en-1-yl]methyl}piperazin-1-yl)-N-{[4-({[(2R)-4-(N,N-dimethylglycyl)morpholin-2-yl]methyl}amino)-3-nitrophenyl]sulfonyl}-2-(1H-pyrrolo[2,3-b]pyridin-5-yloxy)benzamide; 4-(4-{[2-(4-chlorophenyl)-4,4-dimethylcyclohex-1-en-1-yl]methyl}piperazin-1-yl)-N-{[4-({[(2S)-4-(N,N-dimethylglycyl)morpholin-2-yl]methyl}amino)-3-nitrophenyl]sulfonyl}-2-(1H-pyrrolo[2,3-b]pyridin-5-yloxy)benzamide; N-[(5-chloro-6-{[1-(N,N-dimethylglycyl)piperidin-4-yl]methoxy}pyridin-3-yl)sulfonyl]-4-(4-{[2-(4-chlorophenyl)-4,4-dimethylcyclohex-1-en-1-yl]methyl}piperazin-1-yl)-2-(1H-pyrrolo[2,3-b]pyridin-5-yloxy)benzamide; N-[(5-chloro-6-{[(3R)-1-(2,2-difluoroethyl)pyrrolidin-3-yl]oxy}pyridin-3-yl)sulfonyl]-4-(4-{[2-(4-chlorophenyl)-4,4-dimethylcyclohex-1-en-1-yl]methyl}piperazin-1-yl)-2-(1H-pyrrolo[2,3-b]pyridin-5-yloxy)benzamide; 4-(4-{[2-(4-chlorophenyl)-4,4-dimethylcyclohex-1-en-1-yl]methyl}piperazin-1-yl)-N-[(4-{[(3R)-1-(cyanomethyl)pyrrolidin-3-yl]amino}-3-nitrophenyl)sulfonyl]-2-(1H-pyrrolo[2,3-b]pyridin-5-yloxy)benzamide; 4-{4-[(4'-chlorobiphenyl-2-yl)methyl]-4-methoxypiperidin-1-yl}-N-({5-chloro-6-[(4-fluorotetrahydro-2H-pyran-4-yl)methoxy]pyridin-3-yl}sulfonyl)-2-(1H-pyrrolo[2,3-b]pyridin-5-yloxy)benzamide; 4-{4-[(4'-chlorobiphenyl-2-yl)methyl]-4-methoxypiperidin-1-yl}-N-({3-nitro-4-[(tetrahydro-2H-pyran-4-ylmethyl)amino]phenyl}sulfonyl)-2-(1H-pyrrolo[2,3-b]pyridin-5-yloxy)benzamide; 4-(4-{[9-(4-chlorophenyl)-3-(1,3-difluoropropan-2-yl)-3-azaspiro[5.5]undec-8-en-8-yl]methyl}piperazin-1-yl)-N-({3-nitro-4-[(tetrahydro-2H-pyran-4-ylmethyl)amino]phenyl}sulfonyl)-2-(1H-pyrrolo[2,3-b]pyridin-5-yloxy)benzamide; 4-(4-{[9-(4-chlorophenyl)-3-isopropyl-3-azaspiro[5.5]undec-8-en-8-yl]methyl}piperazin-1-yl)-N-({3-nitro-4-[(tetrahydro-2H-pyran-4-ylmethyl)amino]phenyl}sulfonyl)-2-(1H-pyrrolo[2,3-b]pyridin-5-yloxy)benzamide; 4-(4-{[9-(4-chlorophenyl)-3-(1,3-difluoropropan-2-yl)-3-azaspiro[5.5]undec-8-en-8-yl]methyl}piperazin-1-yl)-N-{[5-chloro-6-(tetrahydro-2H-pyran-4-ylmethoxy)pyridin-3-yl]sulfonyl}-2-(1H-pyrrolo[2,3-b]pyridin-5-yloxy)benzamide; 4-(4-{[9-(4-chlorophenyl)-3-isopropyl-3-azaspiro[5.5]undec-8-en-8-yl]methyl}piperazin-1-yl)-N-{[5-chloro-6-(tetrahydro-2H-pyran-4-ylmethoxy)pyridin-3-yl]sulfonyl}-2-(1H-pyrrolo[2,3-b]pyridin-5-yloxy)benzamide; N-({5-chloro-6-[(4-fluoro-1-methylpiperidin-4-yl)methoxy]pyridin-3-yl}sulfonyl)-4-(4-{[2-(4-chlorophenyl)-4,4-dimethylcyclohex-1-en-1-yl]methyl}piperazin-1-yl)-2-(1H-pyrrolo[2,3-b]pyridin-5-yloxy)benzamide; N-[(5-chloro-6-{[1-(N,N-dimethylglycyl)-4-fluoropiperidin-4-yl]methoxy}pyridin-3-yl)sulfonyl]-4-(4-{[2-(4-chlorophenyl)-4,4-dimethylcyclohex-1-en-1-yl]methyl}piperazin-1-yl)-2-(1H-pyrrolo[2,3-b]pyridin-5-yloxy)benzamide; 4-{4-[(4'-chlorobiphenyl-2-yl)methyl]-4-fluoropiperidin-1-yl}-N-({3-nitro-4-[(tetrahydro-2H-pyran-4-ylmethyl)amino]phenyl}sulfonyl)-2-(1H-pyrrolo[2,3-b]pyridin-5-yloxy)benzamide; 4-{4-[(4'-chlorobiphenyl-2-yl)methyl]-4-fluoropiperidin-1-yl}-N-({5-chloro-6-[(4-fluorotetrahydro-2H-pyran-4-yl)methoxy]pyridin-3-yl}sulfonyl)-2-(1H-pyrrolo[2,3-b]pyridin-5-yloxy)benzamide; 4-(4-{[9-(4-chlorophenyl)-3-isopropyl-3-azaspiro[5.5]undec-8-en-8-yl]methyl}piperazin-1-yl)-2-(1H-pyrrolo[2,3-b]pyridin-5-yloxy)-N-({4-[(tetrahydro-2H-pyran-4-ylmethyl)amino]-3-(trifluoromethyl)phenyl}sulfonyl)benzamide; N-[(5-chloro-6-{[(3R)-1-(1,3-difluoropropan-2-yl)pyrrolidin-3-yl]oxy}pyridin-3-yl)sulfonyl]-4-(4-{[2-(4-chlorophenyl)-4,4-dimethylcyclohex-1-en-1-yl]methyl}piperazin-1-yl)-2-(1H-pyrrolo[2,3-b]pyridin-5-yloxy)benzamide; 4-(4-{[2-(4-chlorophenyl)-4,4-dimethylcyclohex-1-en-1-yl]methyl}piperazin-1-yl)-N-({3-nitro-4-[2-(tetrahydrofuran-3-yloxy)ethoxy]phenyl}sulfonyl)-2-(1H-pyrrolo[2,3-b]pyridin-5-yloxy)benzamide; 4-(4-{[2-(4-chlorophenyl)-4,4-dimethylcyclohex-1-en-1-yl]methyl}piperazin-1-yl)-N-[(4-{[(trans-4-cyanocyclohexyl)methyl]amino}-3-nitrophenyl)sulfonyl]-2-(1H-pyrrolo[2,3-b]pyridin-5-yloxy)benzamide; N-[(5-chloro-6-{[4-fluoro-1-(oxetan-3-yl)piperidin-4-yl]methoxy}pyridin-3-yl)sulfonyl]-4-(4-{[2-(4-chlorophenyl)-4,4-dimethylcyclohex-1-en-1-yl]methyl}piperazin-1-yl)-2-(1H-pyrrolo[2,3-b]pyridin-5-yloxy)benzamide; 4-(4-{[2-(4-chlorophenyl)-4,4-dimethylcyclohex-1-en-1-yl]methyl}piperazin-1-yl)-N-({5-cyano-6-[2-(tetrahydro-2H-pyran-4-yl)ethoxy]pyridin-3-yl}sulfonyl)-2-(1H-pyrrolo[2,3-b]pyridin-5-yloxy)benzamide; 4-(4-{[2-(4-chlorophenyl)-4,4-dimethylcyclohex-1-en-1-yl]methyl}piperazin-1-yl)-N-{[4-(3-furylmethoxy)-3-nitrophenyl]sulfonyl}-2-(1H-pyrrolo[2,3-b]pyridin-5-yloxy)benzamide; N-[(5-chloro-6-{[(3R)-1-(1,3-difluoropropan-2-yl)pyrrolidin-3-yl]methoxy}pyridin-3-yl)sulfonyl]-4-(4-{[2-(4-chlorophenyl)-4,4-dimethylcyclohex-1-en-1-yl]methyl}piperazin-1-yl)-2-(1H-pyrrolo[2,3-b]pyridin-5-yloxy)benzamide; N-[(5-chloro-6-{[(3R)-1-(2,2-difluoroethyl)pyrrolidin-3-yl]methoxy}pyridin-3-yl)sulfonyl]-4-(4-{[2-(4-chlorophenyl)-4,4-dimethylcyclohex-1-en-1-yl]methyl}piperazin-1-yl)-2-(1H-pyrrolo[2,3-b]pyridin-5-yloxy)benzamide; N-[(5-chloro-6-{[1-(1,3-difluoropropan-2-yl)-4-fluoropiperidin-4-yl]methoxy}pyridin-3-yl)sulfonyl]-4-(4-{[2-(4-chlorophenyl)-4,4-dimethylcyclohex-1-en-1-yl]methyl}piperazin-1-yl)-2-(1H-pyrrolo[2,3-b]pyridin-5-yloxy)benzamide; N-({3-chloro-4-[(4-fluoro-1-methylpiperidin-4-yl)methoxy]phenyl}sulfonyl)-4-(4-{[2-(4-chlorophenyl)-4,4-dimethylcyclohex-1-en-1-yl]methyl}piperazin-1-yl)-2-(1H-pyrrolo[2,3-b]pyridin-5-yloxy)benzamide; 4-(4-{[2-(4-chlorophenyl)-4,4-dimethylcyclohex-1-en-1-yl]methyl}piperazin-1-yl)-N-{[3-cyano-4-(tetrahydro-2H-pyran-4-ylmethoxy)phenyl]sulfonyl}-2-(1H-pyrrolo[2,3-b]pyridin-5-yloxy)benzamide; N-[(5-chloro-6-{[1-(2,2-difluoroethyl)-4-fluoropiperidin-4-yl]methoxy}pyridin-3-yl)sulfonyl]-4-(4-{[2-(4-chlorophenyl)-4,4-dimethylcyclohex-1-en-1-yl]methyl}piperazin-1-yl)-2-(1H-pyrrolo[2,3-b]pyridin-5-yloxy)benzamide; N-({3-chloro-4-[(4-fluorotetrahydro-2H-pyran-4-yl)methoxy]phenyl}sulfonyl)-4-(4-{[2-(4-chlorophenyl)-4,4-dimethylcyclohex-1-en-1-yl]methyl}piperazin-1-yl)-2-(1H-pyrrolo[2,3-b]pyridin-5-yloxy)benzamide; N-({5-chloro-6-[(4,4-difluorocyclohexyl)methoxy]pyridin-3-yl}sulfonyl)-4-(4-{[2-(4-chlorophenyl)-4,4-dimethylcyclohex-1-en-1-yl]methyl}piperazin-1-yl)-2-(1H-pyrrolo[2,3-b]pyridin-5-yloxy)benzamide; 4-(4-{[2-(4-chlorophenyl)-4,4-dimethylcyclohex-1-en-1-yl]methyl}piperazin-1-yl)-N-{[6-{[1-(1,3-difluoropropan-2-yl)-4-fluoropiperidin-4-yl]methoxy}-5-(trifluoromethyl)pyridin-3-yl]sulfonyl}-2-(1H-pyrrolo[2,3-b]pyridin-5-yloxy)benzamide; 4-(4-{[2-(4-chlorophenyl)-4,4-dimethylcyclohex-1-en-1-yl]methyl}piperazin-1-yl)-N-({5-chloro-6-[2-(tetrahydrofuran-2-yl)ethoxy]pyridin-3-yl}sulfonyl)-2-(1H-pyrrolo[2,3-b]pyridin-5-yloxy)benzamide; 4-(4-{[2-(4-chlorophenyl)-4,4-dimethylcyclohex-1-en-1-yl]methyl}-3-methylpiperazin-1-yl)-N-({3-nitro-4-[(tetrahydro-2H-pyran-4-ylmethyl)amino]phenyl}sulfonyl)-2-(1H-pyrrolo[2,3-b]pyridin-5-yloxy)benzamide; 4-(4-{[2-(4-chlorophenyl)-4,4-dimethylcyclohex-1-en-1-yl]methyl}piperazin-1-yl)-N-[(4-{[3-(cyclopropylamino)propyl]amino}-3-nitrophenyl)sulfonyl]-2-(1H-pyrrolo[2,3-b]pyridin-5-yloxy)benzamide; N-{[5-chloro-6-(2-methoxyethoxy)pyridin-3-yl]sulfonyl}-4-(4-{[2-(4-chlorophenyl)-4,4-dimethylcyclohex-1-en-1-yl]methyl}piperazin-1-yl)-2-(1H-pyrrolo[2,3-b]pyridin-5-yloxy)benzamide; 4-(4-{[2-(4-chlorophenyl)-4,4-dimethylcyclohex-1-en-1-yl]methyl}piperazin-1-yl)-N-{[5-fluoro-6-(tetrahydro-2H-pyran-4-ylmethoxy)pyridin-3-yl]sulfonyl}-2-(1H-pyrrolo[2,3-b]pyridin-5-yloxy)benzamide; N-[(3-chloro-4-{[1-(methoxyacetyl)piperidin-4-yl]methoxy}phenyl)sulfonyl]-4-(4-{[2-(4-chlorophenyl)-4,4-dimethylcyclohex-1-en-1-yl]methyl}piperazin-1-yl)-2-(1H-pyrrolo[2,3-b]pyridin-5-yloxy)benzamide; N-[(3-chloro-4-{[1-(N,N-dimethylglycyl)piperidin-4-yl]methoxy}phenyl)sulfonyl]-4-(4-{[2-(4-chlorophenyl)-4,4-dimethylcyclohex-1-en-1-yl]methyl}piperazin-1-yl)-2-(1H-pyrrolo[2,3-b]pyridin-5-yloxy)benzamide; trans-4-(4-{[2-(4-chlorophenyl)-4,4-dimethylcyclohexyl]methyl}piperidin-1-yl)-N-({3-nitro-4-[(tetrahydro-2H-pyran-4-ylmethyl)amino]phenyl}sulfonyl)-2-(1H-pyrrolo[2,3-b]pyridin-5-yloxy)benzamide; 4-(4-{[2-(4-chlorophenyl)-4,4-dimethylcyclohex-1-en-1-yl]methyl}piperazin-1-yl)-2-(1H-pyrrolo[2,3-b]pyridin-5-yloxy)-N-{[6-(tetrahydro-2H-pyran-4-ylmethoxy)-5-(trifluoromethyl)pyridin-3-yl]sulfonyl}benzamide; N-({5-chloro-6-[(trans-4-hydroxycyclohexyl)methoxy]pyridin-3-yl}sulfonyl)-4-(4-{[2-(4-chlorophenyl)-4,4-dimethylcyclohex-1-en-1-yl]methyl}piperazin-1-yl)-2-(1H-pyrrolo[2,3-b]pyridin-5-yloxy)benzamide; 4-(4-{[2-(4-chlorophenyl)-4,4-dimethylcyclohex-1-en-1-yl]methyl}piperazin-1-yl)-N-({3-cyano-4-[(4-fluorotetrahydro-2H-pyran-4-yl)methoxy]phenyl}sulfonyl)-2-(1H-pyrrolo[2,3-b]pyridin-5-yloxy)benzamide; 4-(4-{[2-(4-chlorophenyl)-4,4-dimethylcyclohex-1-en-1-yl]methyl}piperazin-1-yl)-N-({6-[(trans-4-methoxycyclohexyl)methoxy]-5-(trifluoromethyl)pyridin-3-yl}sulfonyl)-2-(1H-pyrrolo[2,3-b]pyridin-5-yloxy)benzamide; 4-(4-{[2-(4-chlorophenyl)-4,4-dimethylcyclohex-1-en-1-yl]methyl}piperazin-1-yl)-N-({6-[(cis-4-methoxycyclohexyl)methoxy]-5-(trifluoromethyl)pyridin-3-yl}sulfonyl)-2-(1H-pyrrolo[2,3-b]pyridin-5-yloxy)benzamide; N-({5-chloro-6-[(4,4-difluoro-1-hydroxycyclohexyl)methoxy]pyridin-3-yl}sulfonyl)-4-(4-{[2-(4-chlorophenyl)-4,4-dimethylcyclohex-1-en-1-yl]methyl}piperidin-1-yl)-2-(1H-pyrrolo[2,3-b]pyridin-5-yloxy)benzamide; N-[(3-chloro-4-{[trans-4-(morpholin-4-yl)cyclohexyl]methoxy}phenyl)sulfonyl]-4-(4-{[2-(4-chlorophenyl)-4,4-dimethylcyclohex-1-en-1-yl]methyl}piperazin-1-yl)-2-(1H-pyrrolo[2,3-b]pyridin-5-yloxy)benzamide; 4-(4-{[2-(4-chlorophenyl)-4,4-dimethylcyclohex-1-en-1-yl]methyl}piperazin-1-yl)-N-{[4-({3-[cyclopropyl(1,3-thiazol-5-ylmethyl)amino]propyl}amino)-3-nitrophenyl]sulfonyl}-2-(1H-pyrrolo[2,3-b]pyridin-5-yloxy)benzamide; N-({3-chloro-4-[(trans-4-hydroxycyclohexyl)methoxy]phenyl}sulfonyl)-4-(4-{[2-(4-chlorophenyl)-4,4-dimethylcyclohex-1-en-1-yl]methyl}piperazin-1-yl)-2-(1H-pyrrolo[2,3-b]pyridin-5-yloxy)benzamide; 4-(4-{[2-(4-chlorophenyl)-4,4-dimethylcyclohex-1-en-1-yl]methyl}piperazin-1-yl)-N-({3-chloro-4-[(tetrahydro-2H-pyran-4-ylmethyl)amino]phenyl}sulfonyl)-2-(1H-pyrrolo[2,3-b]pyridin-5-yloxy)benzamide; 4-(4-{[2-(4-chlorophenyl)-4,4-dimethylcyclohex-1-en-1-yl]methyl}piperazin-1-yl)-N-({4-[(4-fluorotetrahydro-2H-pyran-4-yl)methoxy]-3-(trifluoromethyl)phenyl}sulfonyl)-2-(1H-pyrrolo[2,3-b]pyridin-5-yloxy)benzamide; 4-(4-{[2-(4-chlorophenyl)-4,4-dimethylcyclohex-1-en-1-yl]methyl}piperazin-1-yl)-N-{[4-({3-[cyclopropyl(2,2,2-trifluoroethyl)amino]propyl}amino)-3-nitrophenyl]sulfonyl}-2-(1H-pyrrolo[2,3-b]pyridin-5-yloxy)benzamide; N-[(3-chloro-4-{[1-(oxetan-3-yl)piperidin-4-yl]methoxy}phenyl)sulfonyl]-4-(4-{[2-(4-chlorophenyl)-4,4-dimethylcyclohex-1-en-1-yl]methyl}piperazin-1-yl)-2-(1H-pyrrolo[2,3-b]pyridin-5-yloxy)benzamide; 4-(4-{[2-(4-chlorophenyl)-4,4-dimethylcyclohex-1-en-1-yl]methyl}piperazin-1-yl)-N-({3,5-difluoro-4-[(4-fluorotetrahydro-2H-pyran-4-yl)methoxy]phenyl}sulfonyl)-2-(1H-pyrrolo[2,3-b]pyridin-5-yloxy)benzamide; 4-(4-{[2-(4-chlorophenyl)-4,4-dimethylcyclohex-1-en-1-yl]methyl}piperazin-1-yl)-N-{[4-({3-[cyclopropyl(oxetan-3-yl)amino]propyl}amino)-3-nitrophenyl]sulfonyl}-2-(1H-pyrrolo[2,3-b]pyridin-5-yloxy)benzamide; N-[(3-chloro-4-{[1-(1-methyl-L-prolyl)piperidin-4-yl]methoxy}phenyl)sulfonyl]-4-(4-{[2-(4-chlorophenyl)-4,4-dimethylcyclohex-1-en-1-yl]methyl}piperazin-1-yl)-2-(1H-pyrrolo[2,3-b]pyridin-5-yloxy)benzamide; 4-(4-{[2-(4-chlorophenyl)-4,4-dimethylcyclohex-1-en-1-yl]methyl}piperazin-1-yl)-N-({3,4-difluoro-5-[(4-fluorotetrahydro-2H-pyran-4-yl)methoxy]phenyl}sulfonyl)-2-(1H-pyrrolo[2,3-b]pyridin-5-yloxy)benzamide; N-[(5-chloro-6-{[(2S)-4-cyclopropylmorpholin-2-yl]methoxy}pyridin-3-yl)sulfonyl]-4-(4-{[2-(4-chlorophenyl)-4,4-dimethylcyclohex-1-en-1-yl]methyl}piperazin-1-yl)-2-(1H-pyrrolo[2,3-b]pyridin-5-yloxy)benzamide; 4-(4-{[2-(4-chlorophenyl)-4,4-dimethylcyclohex-1-en-1-yl]methyl}piperidin-1-yl)-N-({3-nitro-4-[(tetrahydro-2H-pyran-4-ylmethyl)amino]phenyl}sulfonyl)-2-(1H-pyrrolo[2,3-b]pyridin-5-yloxy)benzamide; 4-(4-{[2-(4-chlorophenyl)-4,4-dimethylcyclohex-1-en-1-yl]methyl}piperidin-1-yl)-N-{[3-chloro-4-(tetrahydro-2H-pyran-4-ylmethoxy)phenyl]sulfonyl}-2-(1H-pyrrolo[2,3-b]pyridin-5-yloxy)benzamide; 2-{[(4-{[4-(4-{[2-(4-chlorophenyl)-4,4-dimethylcyclohex-1-en-1-yl]methyl}piperazin-1-yl)-2-(1H-pyrrolo[2,3-b]pyridin-5-yloxy)benzoyl]sulfamoyl}-2-nitrophenyl)amino]methyl}morpholine-4-carboxylate; 2-{[(4-{[4-(4-{[2-(4-chlorophenyl)-4,4-dimethylcyclohex-1-en-1-yl]methyl}piperazin-1-yl)-2-(1H-pyrrolo[2,3-b]pyridin-5-yloxy)benzoyl]sulfamoyl}-2-nitrophenyl)amino]methyl}-N-ethyl-N-methylmorpholine-4-carboxamide; 4-(4-{[2-(4-chlorophenyl)-4,4-dimethylcyclohex-1-en-1-yl]methyl}piperazin-1-yl)-N-{[4-({[4-(methylsulfonyl)morpholin-2-yl]methyl}amino)-3-nitrophenyl]sulfonyl}-2-(1H-pyrrolo[2,3-b]pyridin-5-yloxy)benzamide; 4-(4-{[2-(4-chlorophenyl)-4,4-dimethylcyclohex-1-en-1-yl]methyl}piperazin-1-yl)-N-{[4-({3-[cyclobutyl(cyclopropyl)amino]propyl}amino)-3-nitrophenyl]sulfonyl}-2-(1H-pyrrolo[2,3-b]pyridin-5-yloxy)benzamide; 4-(4-{[2-(4-chlorophenyl)-5,5-difluorocyclohex-1-en-1-yl]methyl}piperazin-1-yl)-N-({3-nitro-4-[(tetrahydro-2H-pyran-4-ylmethyl)amino]phenyl}sulfonyl)-2-(1H-pyrrolo[2,3-b]pyridin-5-yloxy)benzamide; N-[(3-chloro-4-{[4-fluoro-1-(oxetan-3-yl)piperidin-4-yl]methoxy}phenyl)sulfonyl]-4-(4-{[2-(4-chlorophenyl)-4,4-dimethylcyclohex-1-en-1-yl]methyl}piperazin-1-yl)-2-(1H-pyrrolo[2,3-b]pyridin-5-yloxy)benzamide; 4-(4-{[2-(4-chlorophenyl)-4,4-dimethylcyclohex-1-en-1-yl]methyl}piperazin-1-yl)-N-{[3-chloro-4-(tetrahydrofuran-3-ylmethoxy)phenyl]sulfonyl}-2-(1H-pyrrolo[2,3-b]pyridin-5-yloxy)benzamide; 4-(4-{[2-(4-chlorophenyl)-5,5-difluorocyclohex-1-en-1-yl]methyl}piperazin-1-yl)-N-[(4-{[(trans-4-hydroxycyclohexyl)methyl]amino}-3-nitrophenyl)sulfonyl]-2-(1H-pyrrolo[2,3-b]pyridin-5-yloxy)benzamide; N-({3-chloro-4-[(4-fluorotetrahydro-2H-pyran-4-yl)methoxy]phenyl}sulfonyl)-4-(4-{[9-(4-chlorophenyl)-3-(oxetan-3-yl)-3-azaspiro[5.5]undec-8-en-8-yl]methyl}piperazin-1-yl)-2-(1H-pyrrolo[2,3-b]pyridin-5-yloxy)benzamide; 4-(4-{[2-(4-chlorophenyl)-4,4-dimethylcyclohex-1-en-1-yl]methyl}piperazin-1-yl)-N-{[4-({[(2R)-4-cyclopropylmorpholin-2-yl]methyl}amino)-3-nitrophenyl]sulfonyl}-2-(1H-pyrrolo[2,3-b]pyridin-5-yloxy)benzamide; 4-(4-{[2-(4-chlorophenyl)-4,4-dimethylcyclohex-1-en-1-yl]methyl}piperazin-1-yl)-N-{[4-({[(2S)-4-cyclopropylmorpholin-2-yl]methyl}amino)-3-nitrophenyl]sulfonyl}-2-(1H-pyrrolo[2,3-b]pyridin-5-yloxy)benzamide; 4-(4-{[5-(4-chlorophenyl)spiro[2.5]oct-5-en-6-yl]methyl}piperazin-1-yl)-N-({3-nitro-4-[(tetrahydro-2H-pyran-4-ylmethyl)amino]phenyl}sulfonyl)-2-(1H-pyrrolo[2,3-b]pyridin-5-yloxy)benzamide; N-{[5-chloro-6-({4-[cyclopropyl(oxetan-3-yl)amino]cyclohexyl}methoxy)pyridin-3-yl]sulfonyl}-4-(4-{[2-(4-chlorophenyl)-4,4-dimethylcyclohex-1-en-1-yl]methyl}piperazin-1-yl)-2-(1H-pyrrolo[2,3-b]pyridin-5-yloxy)benzamide; 4-(4-{[5-(4-chlorophenyl)spiro[2.5]oct-5-en-6-yl]methyl}piperazin-1-yl)-N-[(4-{[(4-cyclopropylmorpholin-2-yl)methyl]amino}-3-nitrophenyl)sulfonyl]-2-(1H-pyrrolo[2,3-b]pyridin-5-yloxy)benzamide; N-({3-chloro-4-[(4-cyclopropylmorpholin-2-yl)methoxy]phenyl}sulfonyl)-4-(4-{[2-(4-chlorophenyl)-4,4-dimethylcyclohex-1-en-1-yl]methyl}piperazin-1-yl)-2-(1H-pyrrolo[2,3-b]pyridin-5-yloxy)benzamide; N-[(3-chloro-4-{[(4-cyclopropylmorpholin-2-yl)methyl]amino}phenyl)sulfonyl]-4-(4-{[2-(4-chlorophenyl)-4,4-dimethylcyclohex-1-en-1-yl]methyl}piperazin-1-yl)-2-(1H-pyrrolo[2,3-b]pyridin-5-yloxy)benzamide; 2-{[(2-chloro-4-{[4-(4-{[2-(4-chlorophenyl)-4,4-dimethylcyclohex-1-en-1-yl]methyl}piperazin-1-yl)-2-(1H-pyrrolo[2,3-b]pyridin-5-yloxy)benzoyl]sulfamoyl}phenyl)amino]methyl}-N-ethyl-N-methylmorpholine-4-carboxamide; (2S)-2-{[(3-chloro-5-{[4-(4-{[2-(4-chlorophenyl)-4,4-dimethylcyclohex-1-en-1-yl]methyl}piperazin-1-yl)-2-(1H-pyrrolo[2,3-b]pyridin-5-yloxy)benzoyl]sulfamoyl}pyridin-2-yl)oxy]methyl}-N-ethyl-N-methylmorpholine-4-carboxamide; N-[(5-chloro-6-{[(4-cyclopropylmorpholin-2-yl)methyl]amino}pyridin-3-yl)sulfonyl]-4-(4-{[2-(4-chlorophenyl)-4,4-dimethylcyclohex-1-en-1-yl]methyl}piperazin-1-yl)-2-(1H-pyrrolo[2,3-b]pyridin-5-yloxy)benzamide; 2-{[(3-chloro-5-{[4-(4-{[2-(4-chlorophenyl)-4,4-dimethylcyclohex-1-en-1-yl]methyl}piperazin-1-yl)-2-(1H-pyrrolo[2,3-b]pyridin-5-yloxy)benzoyl]sulfamoyl}pyridin-2-yl)amino]methyl}-N-ethyl-N-methylmorpholine-4-carboxamide; 4-(4-{[2-(4-chlorophenyl)-4,4-dimethylcyclohex-1-en-1-yl]methyl}piperazin-1-yl)-N-[(4-{[(trans-4-hydroxy-4-methylcyclohexyl)methyl]amino}-3-nitrophenyl)sulfonyl]-2-(1H-pyrrolo[2,3-b]pyridin-5-yloxy)benzamide; 4-(4-{[2-(4-chlorophenyl)-4,4-dimethylcyclohex-1-en-1-yl]methyl}piperazin-1-yl)-N-[(4-{[(cis-4-hydroxy-4-methylcyclohexyl)methyl]amino}-3-nitrophenyl)sulfonyl]-2-(1H-pyrrolo[2,3-b]pyridin-5-yloxy)benzamide; N-[(5-chloro-6-{[(1R,2R,4R,5R)-5-hydroxy-5-methylbicyclo[2.2.1]hept-2-yl]methoxy}pyridin-3-yl)sulfonyl]-4-(4-{[2-(4-chlorophenyl)-4,4-dimethylcyclohex-1-en-1-yl]methyl}piperazin-1-yl)-2-(1H-pyrrolo[2,3-b]pyridin-5-yloxy)benzamide; 4-(4-{[2-(4-chlorophenyl)-4,4-dimethylcyclohex-1-en-1-yl]methyl}piperazin-1-yl)-N-{[4-({4-[(2-cyanoethyl)(cyclopropyl)amino]cyclohexyl}amino)-3-nitrophenyl]sulfonyl}-2-(1H-pyrrolo[2,3-b]pyridin-5-yloxy)benzamide; N-({5-chloro-6-[(trans-4-hydroxy-4-methylcyclohexyl)methoxy]pyridin-3-yl}sulfonyl)-4-(4-{[5-(4-chlorophenyl)spiro[2.5]oct-5-en-6-yl]methyl}piperazin-1-yl)-2-(1H-pyrrolo[2,3-b]pyridin-5-yloxy)benzamide; 4-(4-{[2-(4-chlorophenyl)-4,4-dimethylcyclohex-1-en-1-yl]methyl}piperazin-1-yl)-N-{[5-chloro-6-(5,6,7,8-tetrahydroimidazo[1,2-a]pyridin-6-ylmethoxy)pyridin-3-yl]sulfonyl}-2-(1H-pyrrolo[2,3-b]pyridin-5-yloxy)benzamide; N-[(5-chloro-6-{[(1R,2S,4R,5R)-5-hydroxy-5-methylbicyclo[2.2.1]hept-2-yl]methoxy}pyridin-3-yl)sulfonyl]-4-(4-{[2-(4-chlorophenyl)-4,4-dimethylcyclohex-1-en-1-yl]methyl}piperazin-1-yl)-2-(1H-pyrrolo[2,3-b]pyridin-5-yloxy)benzamide; 4-(4-{[2-(4-chlorophenyl)-4,4-dimethylcyclohex-1-en-1-yl]methyl}piperazin-1-yl)-N-({4-[(cis-4-hydroxy-4-methylcyclohexyl)methoxy]-3-nitrophenyl}sulfonyl)-2-(1H-pyrrolo[2,3-b]pyridin-5-yloxy)benzamide; N-[(5-chloro-6-{[4-fluoro-1-(oxetan-3-yl)piperidin-4-yl]methoxy}pyridin-3-yl)sulfonyl]-4-(4-{[5-(4-chlorophenyl)spiro[2.5]oct-5-en-6-yl]methyl}piperazin-1-yl)-2-(1H-pyrrolo[2,3-b]pyridin-5-yloxy)benzamide; 4-(4-{[2-(4-chlorophenyl)-4,4-dimethylcyclohex-1-en-1-yl]methyl}piperazin-1-yl)-N-[(4-{[4-(3,3-difluoropyrrolidin-1-yl)cyclohexyl]amino}-3-nitrophenyl)sulfonyl]-2-(1H-pyrrolo[2,3-b]pyridin-5-yloxy)benzamide; N-({5-chloro-6-[(trans-4-hydroxy-4-methylcyclohexyl)methoxy]pyridin-3-yl}sulfonyl)-4-(4-{[2-(4-chlorophenyl)-4,4-dimethylcyclohex-1-en-1-yl]methyl}piperazin-1-yl)-2-(1H-pyrrolo[2,3-b]pyridin-5-yloxy)benzamide; N-({5-chloro-6-[(cis-4-hydroxy-4-methylcyclohexyl)methoxy]pyridin-3-yl}sulfonyl)-4-(4-{[2-(4-chlorophenyl)-4,4-dimethylcyclohex-1-en-1-yl]methyl}piperazin-1-yl)-2-(1H-pyrrolo[2,3-b]pyridin-5-yloxy)benzamide; 4-(4-{[2-(4-chlorophenyl)-4,4-dimethylcyclohex-1-en-1-yl]methyl}piperazin-1-yl)-N-{[4-({4-[(2,2-difluorocyclopropyl)amino]cyclohexyl}amino)-3-nitrophenyl]sulfonyl}-2-(1H-pyrrolo[2,3-b]pyridin-5-yloxy)benzamide; N-({5-chloro-6-[(cis-1-fluoro-4-hydroxycyclohexyl)methoxy]pyridin-3-yl}sulfonyl)-4-(4-{[2-(4-chlorophenyl)-4,4-dimethylcyclohex-1-en-1-yl]methyl}piperazin-1-yl)-2-(1H-pyrrolo[2,3-b]pyridin-5-yloxy)benzamide; 4-(4-{[2-(4-chlorophenyl)-4,4-dimethylcyclohex-1-en-1-yl]methyl}piperazin-1-yl)-N-{[3-nitro-4-(2-oxaspiro[3.5]non-7-ylmethoxy)phenyl]sulfonyl}-2-(1H-pyrrolo[2,3-b]pyridin-5-yloxy)benzamide; 4-(4-{[2-(4-chlorophenyl)-4,4-dimethylcyclohex-1-en-1-yl]methyl}piperazin-1-yl)-N-({4-[(trans-4-hydroxy-4-methylcyclohexyl)methoxy]-3-nitrophenyl}sulfonyl)-2-(1H-pyrrolo[2,3-b]pyridin-5-yloxy)benzamide; 4-(4-{[2-(4-chlorophenyl)-5,5-bis(fluoromethyl)cyclohex-1-en-1-yl]methyl}piperazin-1-yl)-N-({3-nitro-4-[(tetrahydro-2H-pyran-4-ylmethyl)amino]phenyl}sulfonyl)-2-(1H-pyrrolo[2,3-b]pyridin-5-yloxy)benzamide; 4-(4-{[2-(4-chlorophenyl)-4,4-dimethylcyclohex-1-en-1-yl]methyl}piperazin-1-yl)-N-({4-[(4-cyclopropylmorpholin-2-yl)methoxy]-3-nitrophenyl}sulfonyl)-2-(1H-pyrrolo[2,3-b]pyridin-5-yloxy)benzamide; N-({5-chloro-6-[(trans-1-fluoro-4-hydroxy-4-methylcyclohexyl)methoxy]pyridin-3-yl}sulfonyl)-4-(4-{[2-(4-chlorophenyl)-4,4-dimethylcyclohex-1-en-1-yl]methyl}piperazin-1-yl)-2-(1H-pyrrolo[2,3-b]pyridin-5-yloxy)benzamide; N-({5-chloro-6-[(cis-1-fluoro-4-hydroxy-4-methylcyclohexyl)methoxy]pyridin-3-yl}sulfonyl)-4-(4-{[2-(4-chlorophenyl)-4,4-dimethylcyclohex-1-en-1-yl]methyl}piperazin-1-yl)-2-(1H-pyrrolo[2,3-b]pyridin-5-yloxy)benzamide; 4-(4-{[2-(4-chlorophenyl)-4,4-dimethylcyclohex-1-en-1-yl]methyl}piperazin-1-yl)-N-[(3-cyano-4-{[4-fluoro-1-(oxetan-3-yl)piperidin-4-yl]methoxy}phenyl)sulfonyl]-2-(1H-pyrrolo[2,3-b]pyridin-5-yloxy)benzamide; 4-(4-{[2-(4-chlorophenyl)-4,4-dimethylcyclohex-1-en-1-yl]methyl}piperazin-1-yl)-N-[(4-{[(trans-4-ethyl-4-hydroxycyclohexyl)methyl]amino}-3-nitrophenyl)sulfonyl]-2-(1H-pyrrolo[2,3-b]pyridin-5-yloxy)benzamide; 4-(4-{[2-(4-chlorophenyl)-4,4-dimethylcyclohex-1-en-1-yl]methyl}piperazin-1-yl)-N-[(4-{[(cis-4-ethyl-4-hydroxycyclohexyl)methyl]amino}-3-nitrophenyl)sulfonyl]-2-(1H-pyrrolo[2,3-b]pyridin-5-yloxy)benzamide; 4-(4-{[2-(4-chlorophenyl)-5-(methoxymethyl)-5-methylcyclohex-1-en-1-yl]methyl}piperazin-1-yl)-N-({3-nitro-4-[(tetrahydro-2H-pyran-4-ylmethyl)amino]phenyl}sulfonyl)-2-(1H-pyrrolo[2,3-b]pyridin-5-yloxy)benzamide; 4-(4-{[2-(4-chlorophenyl)-4,4-dimethylcyclohex-1-en-1-yl]methyl}piperazin-1-yl)-N-{[3-nitro-4-({[(2S)-4-(oxetan-3-yl)morpholin-2-yl]methyl}amino)phenyl]sulfonyl}-2-(1H-pyrrolo[2,3-b]pyridin-5-yloxy)benzamide; N-({3-chloro-4-[(trans-4-hydroxy-4-methylcyclohexyl)methoxy]phenyl}sulfonyl)-4-(4-{[2-(4-chlorophenyl)-4,4-dimethylcyclohex-1-en-1-yl]methyl}piperazin-1-yl)-2-(1H-pyrrolo[2,3-b]pyridin-5-yloxy)benzamide; 4-(4-{[2-(4-chlorophenyl)-4,4-dimethylcyclohex-1-en-1-yl]methyl}piperazin-1-yl)-N-{[4-({4-[(2-cyanoethyl)(cyclopropyl)amino]-1-fluorocyclohexyl}methoxy)-3-nitrophenyl]sulfonyl}-2-(1H-pyrrolo[2,3-b]pyridin-5-yloxy)benzamide; 4-(4-{[2-(4-chlorophenyl)-4,4-dimethylcyclohex-1-en-1-yl]methyl}piperazin-1-yl)-N-({5-nitro-6-[(tetrahydro-2H-pyran-4-ylmethyl)amino]pyridin-3-yl}sulfonyl)-2-(1H-pyrrolo[2,3-b]pyridin-5-yloxy)benzamide; 4-(4-{[2-(4-chlorophenyl)-4,4-dimethylcyclohex-1-en-1-yl]methyl}piperazin-1-yl)-N-({3-nitro-4-[(2-oxaspiro[3.5]non-7-ylmethyl)amino]phenyl}sulfonyl)-2-(1H-pyrrolo[2,3-b]pyridin-5-yloxy)benzamide; 4-(4-{[2-(4-chlorophenyl)-4,4-dimethylcyclohex-1-en-1-yl]methyl}piperazin-1-yl)-N-[(4-{[(4-cyano-4-methylcyclohexyl)methyl]amino}-3-nitrophenyl)sulfonyl]-2-(1H-pyrrolo[2,3-b]pyridin-5-yloxy)benzamide; Pivalic acid {[4-(4-{[2-(4-chlorophenyl)-4,4-dimethylcyclohex-1-en-1-yl]methyl}piperazin-1-yl)-2-(1H-pyrrolo[2,3-b]pyridin-5-yloxy)benzoyl]({4-[(4-fluorotetrahydro-2H-pyran-4-yl)methoxy]-3-nitrophenyl}sulfonyl)amino}methyl; butyric acid {[4-(4-{[2-(4-chlorophenyl)-4,4-dimethylcyclohex-1-en-1-yl]methyl}piperazin-1-yl)-2-(1H-pyrrolo[2,3-b]pyridin-5-yloxy)benzoyl]({4-[(4-fluorotetrahydro-2H-pyran-4-yl)methoxy]-3-nitrophenyl}sulfonyl)amino}methyl; 4-(4-{[2-(4-chlorophenyl)-4,4-dimethylcyclohex-1-en-1-yl]methyl}piperazin-1-yl)-2-(1H-pyrrolo[2,3-b]pyridin-5-yloxy)-N-{[3-(tetrahydro-2H-pyran-4-ylmethyl)-3H-[1,2,3]triazolo[4,5-b]pyridin-6-yl]sulfonyl}benzamide; 4-(4-{[2-(4-chlorophenyl)-4,4-dimethylcyclohex-1-en-1-yl]methyl}piperazin-1-yl)-N-[(6-{[(trans-4-hydroxy-4-methylcyclohexyl)methyl]amino}-5-nitropyridin-3-yl)sulfonyl]-2-(1H-pyrrolo[2,3-b]pyridin-5-yloxy)benzamide; 4-(4-{[2-(4-chlorophenyl)-4,4-dimethylcyclohex-1-en-1-yl]methyl}piperazin-1-yl)-N-[(5-cyano-6-{[4-fluoro-1-(oxetan-3-yl)piperidin-4-yl]methoxy}pyridin-3-yl)sulfonyl]-2-(1H-pyrrolo[2,3-b]pyridin-5-yloxy)benzamide; N-(4-{[4-(4-{[2-(4-chlorophenyl)-4,4-dimethylcyclohex-1-en-1-yl]methyl}piperazin-1-yl)-2-(1H-pyrrolo[2,3-b]pyridin-5-yloxy)benzoyl]sulfamoyl}-2-nitrophenyl)morpholine-4-carboxamide; 4-(4-{[2-(4-chlorophenyl)-4,4-dimethylcyclohex-1-en-1-yl]methyl}piperazin-1-yl)-N-{[4-({[4-(methoxymethyl)cyclohexyl]methyl}amino)-3-nitrophenyl]sulfonyl}-2-(1H-pyrrolo[2,3-b]pyridin-5-yloxy)benzamide; 4-(4-{[2-(4-chlorophenyl)-4,4-dimethylcyclohex-1-en-1-yl]methyl}piperazin-1-yl)-N-[(5-chloro-6-{[1-(1,3-thiazol-2-yl)piperidin-4-yl]methoxy}pyridin-3-yl)sulfonyl]-2-(1H-pyrrolo[2,3-b]pyridin-5-yloxy)benzamide; 4-(4-{[2-(4-chlorophenyl)-4,4-dimethylcyclohex-1-en-1-yl]methyl}piperazin-1-yl)-N-[(6-{[(cis-4-hydroxy-4-methylcyclohexyl)methyl]amino}-5-nitropyridin-3-yl)sulfonyl]-2-(1H-pyrrolo[2,3-b]pyridin-5-yloxy)benzamide; 4-(4-{[2-(4-chlorophenyl)-5-methoxy-5-methylcyclohex-1-en-1-yl]methyl}piperazin-1-yl)-N-[(4-{[(trans-4-hydroxy-4-methylcyclohexyl)methyl]amino}-3-nitrophenyl)sulfonyl]-2-(1H-pyrrolo[2,3-b]pyridin-5-yloxy)benzamide; 4-(4-{[2-(4-chlorophenyl)-5-methoxy-5-methylcyclohex-1-en-1-yl]methyl}piperazin-1-yl)-N-({3-nitro-4-[(tetrahydro-2H-pyran-4-ylmethyl)amino]phenyl}sulfonyl)-2-(1H-pyrrolo[2,3-b]pyridin-5-yloxy)benzamide; and therapeutically acceptable salts and metabolites thereof 3. The compound of claim 1 or claim 2 selected from:

9. The compound 4-(4-{[2-(4-chlorophenyl)-4,4-dimethylcyclohex-1-en-1-yl]methyl}piperazin-1-yl)-N-({3-nitro-4-[(tetrahydro-2H-pyran-4-ylmethyl)amino]phenyl}sulfonyl)-2-(1H-pyrrolo[2,3-b]pyridin-5-yloxy)benzamide or a pharmaceutically acceptable salt thereof.

10. The compound trans-4-(4-{[2-(4-chlorophenyl)-4,4-dimethylcyclohex-1-en-1-yl]methyl}piperazin-1-yl)-N-({4-[(4-morpholin-4-ylcyclohexyl)amino]-3-nitrophenyl}sulfonyl)-2-(1H-pyrrolo[2,3-b]pyridin-5-yloxy)benzamide or a pharmaceutically acceptable salt thereof.

11. The compound cis-4-(4-{[2-(4-chlorophenyl)-4,4-dimethylcyclohex-1-en-1-yl]methyl}piperazin-1-yl)-N-[(4-{[(4-methoxycyclohexyl)methyl]amino}-3-nitrophenyl)sulfonyl]-2-(1H-pyrrolo[2,3-b]pyridin-5-yloxy)benzamide or a pharmaceutically acceptable salt thereof.

12. The compound trans-4-(4-{[2-(4-chlorophenyl)-4,4-dimethylcyclohex-1-en-1-yl]methyl}piperazin-1-yl)-N-[(4-{[(4-methoxycyclohexyl)methyl]amino}-3-nitrophenyl)sulfonyl]-2-(1H-pyrrolo[2,3-b]pyridin-5-yloxy)benzamide or a pharmaceutically acceptable salt thereof.

13. The compound 4-(4-{[2-(4-chlorophenyl)-4,4-dimethylcyclohex-1-en-1-yl]methyl}piperazin-1-yl)-N-({4-[(4-fluorotetrahydro-2H-pyran-4-yl)methoxy]-3-nitrophenyl}sulfonyl)-2-(1H-pyrrolo[2,3-b]pyridin-5-yloxy)benzamide or a pharmaceutically acceptable salt thereof.

14. The compound 4-(4-{[2-(4-chlorophenyl)-4,4-dimethylcyclohex-1-en-1-yl]methyl}piperazin-1-yl)-N-[(4-{[(trans-4-hydroxy-4-methylcyclohexyl)methyl]amino}-3-nitrophenyl)sulfonyl]-2-(1H-pyrrolo[2,3-b]pyridin-5-yloxy)benzamide or a pharmaceutically acceptable salt thereof.

15. The compound 4-(4-{[2-(4-chlorophenyl)-4,4-dimethylcyclohex-1-en-1-yl]methyl}piperazin-1-yl)-N-[(4-{[(cis-4-hydroxy-4-methylcyclohexyl)methyl]amino}-3-nitrophenyl)sulfonyl]-2-(1H-pyrrolo[2,3-b]pyridin-5-yloxy)benzamide or a pharmaceutically acceptable salt thereof.

16. The compound N-[(5-chloro-6-{[4-fluoro-1-(oxetan-3-yl)piperidin-4-yl]methoxy}pyridin-3-yl)sulfonyl]-4-(4-{[2-(4-chlorophenyl)-4,4-dimethylcyclohex-1-en-1-yl]methyl}piperazin-1-yl)-2-(1H-pyrrolo[2,3-b]pyridin-5-yloxy)benzamide or a pharmaceutically acceptable salt thereof.

17. The compound N-({5-bromo-6-[(1-tetrahydro-2H-pyran-4-ylpiperidin-4-yl)amino]pyridin-3-yl}sulfonyl)-4-(4-{[2-(4-chlorophenyl)-4,4-dimethylcyclohex-1-en-1-yl]methyl}piperazin-1-yl)-2-(1H-pyrrolo[2,3-b]pyridin-5-yloxy)benzamide; or a pharmaceutically acceptable salt thereof.

18. The compound 4-(4-{[2-(4-chlorophenyl)-4,4-dimethylcyclohex-1-en-1-yl]methyl}piperazin-1-yl)-N-[(4-{[(3R)-1-(methylsulfonyl)pyrrolidin-3-yl]amino}-3-nitrophenyl)sulfonyl]-2-(1H-pyrrolo[2,3-b]pyridin-5-yloxy)benzamide; or a pharmaceutically acceptable salt thereof.

19. The compound 4-(4-{[2-(4-chlorophenyl)-4,4-dimethylcyclohex-1-en-1-yl]methyl}piperazin-1-yl)-N-{[4-({3-[cyclopropyl(oxetan-3-yl)amino]propyl}amino)-3-nitrophenyl]sulfonyl}-2-(1H-pyrrolo[2,3-b]pyridin-5-yloxy)benzamide; or a pharmaceutically acceptable salt thereof.

20. The compound 4-(4-{[2-(4-chlorophenyl)-5-methoxy-5-methylcyclohex-1-en-1-yl]methyl}piperazin-1-yl)-N-({3-nitro-4-[(tetrahydro-2H-pyran-4-ylmethyl)amino]phenyl}sulfonyl)-2-(1H-pyrrolo[2,3-b]pyridin-5-yloxy)benzamide; or a pharmaceutically acceptable salt thereof.

21. The compound is 4-(4-{[2-(4-chlorophenyl)-4,4-dimethylcyclohex-1-en-1-yl]methyl}piperazin-1-yl)-N-[(4-{[(trans-4-hydroxy-4-methylcyclohexyl)methyl]amino}-3-nitrophenyl)sulfonyl]-2-(1H-pyrrolo[2,3-b]pyridin-5-yloxy)benzamide; 4-(4-{[2-(4-chlorophenyl)-4,4-dimethylcyclohex-1-en-1-yl]methyl}piperazin-1-yl)-N-[(4-{[(3R)-1-(methylsulfonyl)pyrrolidin-3-yl]amino}-3-nitrophenyl)sulfonyl]-2-(1H-pyrrolo[2,3-b]pyridin-5-yloxy)benzamide; 4-(4-{[2-(4-chlorophenyl)-4,4-dimethylcyclohex-1-en-1-yl]methyl}piperazin-1-yl)-N-{[4-({3-[cyclopropyl(oxetan-3-yl)amino]propyl}amino)-3-nitrophenyl]sulfonyl}-2-(1H-pyrrolo[2,3-b]pyridin-5-yloxy)benzamide; 3. The compound of claim 1 or claim 2, selected from: or a pharmaceutically acceptable salt thereof.

22. The compound is N-[(5-chloro-6-{[1-(cyanomethyl)piperidin-4-yl]methoxy}pyridin-3-yl)sulfonyl]-4-(4-{[2-(4-chlorophenyl)-4,4-dimethylcyclohex-1-en-1-yl]methyl}piperazin-1-yl)-2-(1H-pyrrolo[2,3-b]pyridin-5-yloxy)benzamide; 4-(4-{[2-(4-chlorophenyl)-4,4-dimethylcyclohex-1-en-1-yl]methyl}piperazin-1-yl)-N-{[4-({3-[cyclopropyl(oxetan-3-yl)amino]propyl}amino)-3-nitrophenyl]sulfonyl}-2-(1H-pyrrolo[2,3-b]pyridin-5-yloxy)benzamide; 3. The compound of claim 1 or claim 2, selected from: or a pharmaceutically acceptable salt thereof.

23. The compound is 4-(4-{[2-(4-chlorophenyl)-4,4-dimethylcyclohex-1-en-1-yl]methyl}piperazin-1-yl)-N-[(4-{[(trans-4-hydroxy-4-methylcyclohexyl)methyl]amino}-3-nitrophenyl)sulfonyl]-2-(1H-pyrrolo[2,3-b]pyridin-5-yloxy)benzamide; 4-(4-{[2-(4-chlorophenyl)-4,4-dimethylcyclohex-1-en-1-yl]methyl}piperazin-1-yl)-N-[(4-{[(cis-4-hydroxy-4-methylcyclohexyl)methyl]amino}-3-nitrophenyl)sulfonyl]-2-(1H-pyrrolo[2,3-b]pyridin-5-yloxy)benzamide 3. The compound of claim 1 or claim 2, selected from: or a pharmaceutically acceptable salt thereof.

24. The compound 4-(4-{[2-(4-chlorophenyl)-4,4-dimethylcyclohex-1-en-1-yl]methyl}piperazin-1-yl)-N-{[4-({3-[cyclopropyl(oxetan-3-yl)amino]propyl}amino)-3-nitrophenyl]sulfonyl}-2-(1H-pyrrolo[2,3-b]pyridin-5-yloxy)benzamide; or a pharmaceutically acceptable salt thereof.

25. The compound is 4-(4-{[2-(4-chlorophenyl)-4,4-dimethylcyclohex-1-en-1-yl]methyl}piperazin-1-yl)-N-{[3-nitro-4-({[(3R)-1-tetrahydro-2H-pyran-4-ylpyrrolidin-3-yl]methyl}amino)phenyl]sulfonyl}-2-(1H-pyrrolo[2,3-b]pyridin-5-yloxy)benzamide; 3. The compound of claim 1 or claim 2, selected from 4-(4-{[2-(4-chlorophenyl)-4,4-dimethylcyclohex-1-en-1-yl]methyl}piperazin-1-yl)-N-[(4-{[(4-methylmorpholin-2-yl)methyl]amino}-3-nitrophenyl)sulfonyl]-2-(1H-pyrrolo[2,3-b]pyridin-5-yloxy)benzamide; or a pharmaceutically acceptable salt thereof.

26. The compound is 4-(4-{[2-(4-chlorophenyl)-4,4-dimethylcyclohex-1-en-1-yl]methyl}piperazin-1-yl)-N-[(3-nitro-4-{[(3S)-tetrahydro-2H-pyran-3-ylmethyl]amino}phenyl)sulfonyl]-2-(1H-pyrrolo[2,3-b]pyridin-5-yloxy)benzamide; 4-(4-{[2-(4-chlorophenyl)-4,4-dimethylcyclohex-1-en-1-yl]methyl}piperazin-1-yl)-N-{[4-(1,4-dioxan-2-ylmethoxy)-3-nitrophenyl]sulfonyl}-2-(1H-pyrrolo[2,3-b]pyridin-5-yloxy)benzamide; N-({5-bromo-6-[(1-tetrahydro-2H-pyran-4-ylpiperidin-4-yl)amino]pyridin-3-yl}sulfonyl)-4-(4-{[2-(4-chlorophenyl)-4,4-dimethylcyclohex-1-en-1-yl]methyl}piperazin-1-yl)-2-(1H-pyrrolo[2,3-b]pyridin-5-yloxy)benzamide; N-[(4-{[(4-aminotetrahydro-2H-pyran-4-yl)methyl]amino}-3-nitrophenyl)sulfonyl]-4-(4-{[2-(4-chlorophenyl)-4,4-dimethylcyclohex-1-en-1-yl]methyl}piperazin-1-yl)-2-(1H-pyrrolo[2,3-b]pyridin-5-yloxy)benzamide; 4-(4-{[2-(4-chlorophenyl)-4,4-dimethylcyclohex-1-en-1-yl]methyl}piperazin-1-yl)-N-{[3-nitro-4-({[(3R)-1-tetrahydro-2H-pyran-4-ylpyrrolidin-3-yl]methyl}amino)phenyl]sulfonyl}-2-(1H-pyrrolo[2,3-b]pyridin-5-yloxy)benzamide; 4-(4-{[2-(4-chlorophenyl)-4,4-dimethylcyclohex-1-en-1-yl]methyl}piperazin-1-yl)-N-[(4-{[(4-methylmorpholin-2-yl)methyl]amino}-3-nitrophenyl)sulfonyl]-2-(1H-pyrrolo[2,3-b]pyridin-5-yloxy)benzamide; 4-(4-{[2-(4-chlorophenyl)-4,4-dimethylcyclohex-1-en-1-yl]methyl}piperazin-1-yl)-N-[(4-{[(3R)-1-(methylsulfonyl)pyrrolidin-3-yl]amino}-3-nitrophenyl)sulfonyl]-2-(1H-pyrrolo[2,3-b]pyridin-5-yloxy)benzamide; 4-(4-{[2-(4-chlorophenyl)-4,4-dimethylcyclohex-1-en-1-yl]methyl}piperazin-1-yl)-N-({4-[(4-methoxytetrahydro-2H-pyran-4-yl)methoxy]-3-nitrophenyl}sulfonyl)-2-(1H-pyrrolo[2,3-b]pyridin-5-yloxy)benzamide; N-[(5-chloro-6-{[1-(cyanomethyl)piperidin-4-yl]methoxy}pyridin-3-yl)sulfonyl]-4-(4-{[2-(4-chlorophenyl)-4,4-dimethylcyclohex-1-en-1-yl]methyl}piperazin-1-yl)-2-(1H-pyrrolo[2,3-b]pyridin-5-yloxy)benzamide; 4-(4-{[2-(4-chlorophenyl)-4,4-dimethylcyclohex-1-en-1-yl]methyl}piperazin-1-yl)-N-{[4-({3-[cyclopropyl(oxetan-3-yl)amino]propyl}amino)-3-nitrophenyl]sulfonyl}-2-(1H-pyrrolo[2,3-b]pyridin-5-yloxy)benzamide; N-[(5-chloro-6-{[(1R,2S,4R,5R)-5-hydroxy-5-methylbicyclo[2.2.1]hept-2-yl]methoxy}pyridin-3-yl)sulfonyl]-4-(4-{[2-(4-chlorophenyl)-4,4-dimethylcyclohex-1-en-1-yl]methyl}piperazin-1-yl)-2-(1H-pyrrolo[2,3-b]pyridin-5-yloxy)benzamide; 4-(4-{[2-(4-chlorophenyl)-4,4-dimethylcyclohex-1-en-1-yl]methyl}piperazin-1-yl)-N-[(6-{[(cis-4-hydroxy-4-methylcyclohexyl)methyl]amino}-5-nitropyridin-3-yl)sulfonyl]-2-(1H-pyrrolo[2,3-b]pyridin-5-yloxy)benzamide; 4-(4-{[2-(4-chlorophenyl)-5-methoxy-5-methylcyclohex-1-en-1-yl]methyl}piperazin-1-yl)-N-({3-nitro-4-[(tetrahydro-2H-pyran-4-ylmethyl)amino]phenyl}sulfonyl)-2-(1H-pyrrolo[2,3-b]pyridin-5-yloxy)benzamide; or a pharmaceutically acceptable salt thereof 3. The compound of claim 1 or claim 2 selected from:

27. The compound N-[(5-chloro-6-{[1-(cyanomethyl)piperidin-4-yl]methoxy}pyridin-3-yl)sulfonyl]-4-(4-{[2-(4-chlorophenyl)-4,4-dimethylcyclohex-1-en-1-yl]methyl}piperazin-1-yl)-2-(1H-pyrrolo[2,3-b]pyridin-5-yloxy)benzamide; or a pharmaceutically acceptable salt thereof.

28. The compound is N-[(4-{[(4-aminotetrahydro-2H-pyran-4-yl)methyl]amino}-3-nitrophenyl)sulfonyl]-4-(4-{[2-(4-chlorophenyl)-4,4-dimethylcyclohex-1-en-1-yl]methyl}piperazin-1-yl)-2-(1H-pyrrolo[2,3-b]pyridin-5-yloxy)benzamide; 4-(4-{[2-(4-chlorophenyl)-4,4-dimethylcyclohex-1-en-1-yl]methyl}piperazin-1-yl)-N-({4-[(4-methoxytetrahydro-2H-pyran-4-yl)methoxy]-3-nitrophenyl}sulfonyl)-2-(1H-pyrrolo[2,3-b]pyridin-5-yloxy)benzamide; or a pharmaceutically acceptable salt thereof 3. The compound of claim 1 or claim 2 selected from:

29. The compound 4-(4-{[2-(4-chlorophenyl)-4,4-dimethylcyclohex-1-en-1-yl]methyl}piperazin-1-yl)-N-({4-[(4-methoxytetrahydro-2H-pyran-4-yl)methoxy]-3-nitrophenyl}sulfonyl)-2-(1H-pyrrolo[2,3-b]pyridin-5-yloxy)benzamide or a pharmaceutically acceptable salt thereof.

30. A composition for treating bladder cancer, brain cancer, breast cancer, bone marrow cancer, cervical cancer, chronic lymphocytic leukemia, colorectal cancer, esophageal cancer, hepatocellular carcinoma, lymphoblastic leukemia, follicular lymphoma, lymphoid malignancies of T-cell or B-cell origin, melanoma, myeloid leukemia, myeloma, oral cancer, ovarian cancer, non-small cell lung cancer, chronic lymphocytic leukemia, myeloma, prostate cancer, small cell lung cancer or splenic cancer, comprising an excipient and a therapeutically effective amount of a compound of claim 1 or claim 2.

31. A method of treating bladder cancer, brain cancer, breast cancer, bone marrow cancer, cervical cancer, chronic lymphocytic leukemia, colorectal cancer, esophageal cancer, hepatocellular carcinoma, lymphoblastic leukemia, follicular lymphoma, lymphoid malignancies of T-cell or B-cell origin, melanoma, myeloid leukemia, myeloma, oral cancer, ovarian cancer, non-small cell lung cancer, chronic lymphocytic leukemia, myeloma, prostate cancer, small cell lung cancer, or splenic cancer in a patient, comprising administering to the patient a therapeutically effective amount of a compound of claim 1 or claim 2.

32. 10. A method of treating bladder cancer, brain cancer, breast cancer, bone marrow cancer, cervical cancer, chronic lymphocytic leukemia, colorectal cancer, esophageal cancer, hepatocellular carcinoma, lymphoblastic leukemia, follicular lymphoma, lymphoid malignancies of T-cell or B-cell origin, melanoma, myeloid leukemia, myeloma, oral cancer, ovarian cancer, non-small cell lung cancer, chronic lymphocytic leukemia, myeloma, prostate cancer, small cell lung cancer, or splenic cancer in a patient, comprising administering to the patient a therapeutically effective amount of a compound of claim 1 or claim 2 and therapeutically effective amounts of one or more additional therapeutic agents.

Images