Process for the synthesis of quinazoline compounds

Abstract

To provide a method for synthesizing a compound useful for treating cancer.SOLUTION: Contacting a compound of formula (II) with an organomagnesium compound, transferring the obtained compound to a continuous stirred tank reactor (CSTR) containing a zinc compound, and contacting the thereby obtained compound with a compound of formula (III), a transition metal catalyst precursor and a chiral ligand to obtain the target compound.SELECTED DRAWING: None

Description

[Technical Field]

[0001] CROSS-REFERENCE TO RELATED APPLICATIONS This application claims the benefit of U.S. Provisional Patent Application No. 63 / 307,529, filed February 7, 2022, which is incorporated herein by reference in its entirety for all purposes.

[0002] Provided herein are methods for synthesizing compounds useful in the treatment of cancer, comprising a quinazolinyl core moiety and at least one stereoisomeric or atropisomeric moiety. [Background technology]

[0003] The configuration of the biaryl axis often plays an important role in the pharmacological properties of biologically active compounds and is a fundamental basis for useful reagents and catalysts in asymmetric synthesis. Highly atroposelective cross-coupling, particularly of heterocycles for the synthesis of biheteroaryls, remains a challenging and unsolved problem. Furthermore, scaling up such processes to commercial / industrial scale often introduces unforeseen and unexpected process and synthetic difficulties. The present disclosure provides an improved method for the nonselective synthesis of aminopyridinyl-quinazolinyl compounds via the Negishi coupling utilizing chiral ligands such as chiraphites.

[0004] Thus, there is an urgent need for methods that allow efficient and effective scale-up for the synthesis of compounds such as those described herein. Summary of the Invention

[0005] Solutions to the above problems and other problems in the art are provided herein.

[0006] In a first aspect, provided herein is a method for synthesizing a compound of formula (I) described herein, the method comprising the steps of: (a) contacting a compound of formula (II) described herein with an organomagnesium compound, thereby forming a compound of formula (IIa) described herein; (b) transferring the compound of formula (IIa) of step (a) to a continuous stirred tank reactor (CSTR) containing a zinc compound, thereby synthesizing a compound of formula (IIb) described herein; and contacting compound (IIb) of step (b) with a compound of formula (III) described herein, a transition metal catalyst precursor described herein, and a chiral ligand described herein, thereby synthesizing a compound of formula (I).

[0007] In one embodiment, the compound of formula (II) is prepared according to method P2 described herein.

[0008] In one embodiment, the compound of formula (III) is prepared according to method P4 described herein.

[0009] In one embodiment of the methods described herein, Formula (I) comprises a compound of Formula (Ia), (Ib), (Ic), or (Id) as described herein.

[0010] In one embodiment of the methods described herein, Formula (I) comprises a compound of Formula (1) described herein.

[0011] In another aspect, there is provided a method (P5) for synthesizing a compound of formula (2) described herein, the method comprising: (a) contacting a compound of formula (4a) described herein with i-PrMgCl, followed by contacting with hydroxylamine, thereby synthesizing a compound of formula (4c) described herein; (b) contacting a compound of formula (4c) described herein with TFAA and triethylamine in acetonitrile, followed by contacting with ammonia, thereby synthesizing a compound of formula (4e) described herein; or (c) contacting a compound of formula (4e) described herein with a chlorinating agent, thereby synthesizing a compound of formula (4) described herein. Provided herein are methods for synthesizing a compound of formula (2) described herein, comprising the steps of: synthesizing a compound of formula (5); contacting a compound of formula (4) described herein with CO in the presence of DBU, thereby synthesizing a compound of formula (5); contacting a compound of formula (5) described herein with POCl and DIPEA, followed by tert-butyl (S)-3-methylpiperazine-1-carboxylate in DIPEA, thereby synthesizing a compound of formula (5b); and contacting a compound of formula (5b) described herein with KF, DABCO, and MsOH, thereby forming a compound of formula (2) described herein.

[0012] In another aspect, there is provided a process (P7) for synthesizing a compound of formula (G) as described herein, or a tautomer, stereoisomer, atropisomer, or pharmaceutically acceptable salt thereof, comprising reacting a compound of formula (I), or a solvate, tautomer, stereoisomer, atropisomer, or salt thereof, with X as described herein in the presence of a base as described herein and an activating agent as described herein. A and optionally contacting a compound of formula (G1) with a moiety comprising a PG group and optionally R 1and contacting the compound of step (b) with a compound of formula (VII) described herein in the presence of an activating agent, as described herein, followed by contacting with a base, as described herein, thereby producing a compound of formula (G), or a tautomer, stereoisomer, atropisomer, or pharmaceutically acceptable salt thereof.

[0013] Further, a method (P8) for synthesizing a compound of formula (1) described herein, or a pharmaceutically acceptable salt thereof, includes the steps of contacting a pre-cooled solution containing a compound of formula (2) described herein, or a salt thereof, with a pre-cooled solution containing i-PrMgCl·LiCl using a flow rate that provides a residence time for Mg-Br exchange of about 15 to 150 seconds, thereby synthesizing a compound of formula (2a) described herein; a) transferring the compound of formula (a) and maintaining a constant residence time of about 3 to 7 minutes at about -20°C to 20°C, thereby synthesizing a compound of formula (2b) described herein; b) contacting the compound of formula (2b) with NaTFA and a compound of formula (3) described herein; c) contacting the mixture of step (c) or a salt thereof with a Pd or Ni catalyst precursor and a chiral ligand, thereby synthesizing a compound of formula (11) described herein, or a solvate or salt thereof; A (In the formula, X A is an expression TIFF2026016384000001.tif13170) and a base as described herein, thereby synthesizing a compound of formula (1b) as described herein, or a solvate or pharmaceutically acceptable salt thereof; contacting a compound of formula (1b) with MsOH in an acid, thereby synthesizing a compound of formula (1a) as described herein, or a solvate or pharmaceutically acceptable salt thereof; and a compound of formula (1a) or a solvate or pharmaceutically acceptable salt thereof. Provided herein is a method for synthesizing a compound of formula (1) described herein, or a pharmaceutically acceptable salt thereof, comprising contacting TIFF2026016384000002.tif18170 in the presence of an activating agent, followed by contacting with a base, thereby producing a compound of formula (1), or a pharmaceutically acceptable salt thereof.

[0014] The present embodiments can be more fully understood by reference to the detailed description and examples, which are intended to exemplify non-limiting embodiments. [Brief explanation of the drawings]

[0015] [Figure 1] FIG. 1 shows an exemplary hardware setup for the continuous flow reaction described herein. DETAILED DESCRIPTION OF THE INVENTION

[0016] Unless otherwise defined, all technical and scientific terms used herein have the same meaning as those generally understood by those skilled in the art.For example, see Singleton et al.DICTIONARY OF MICROBIOLOGY AND MOLECULAR BIOLOGY 2nd ed., J.Wiley&Sons (New York, NY 1994); Sambrook et al.MOLECULAR CLONING, A LABORATORY MANUAL, Cold Springs Harbor Press (Cold Springs Harbor, NY 1989).In carrying out the present invention, any method, device and material similar or equivalent to those described herein can be used.

[0017] The following definitions are provided to facilitate understanding of certain terms used frequently herein and are not meant to limit the scope of the present disclosure. All references mentioned herein are incorporated by reference in their entirety.

[0018] As used herein, unless otherwise specified, the terms "about" and "approximately," when referring to a dose, amount, or weight percent of a component of a composition or dosage form, mean a dose, amount, or weight percent that would be recognized by one of ordinary skill in the art to provide an equivalent pharmacological effect to that obtained from the specified dose, amount, or weight percent. The equivalent dose, amount, or weight percent may be within 30%, 20%, 15%, 10%, 5%, 1%, or less of the specified dose, amount, or weight percent.

[0019] The term "residence time" refers to the residence time distribution (RTD) of a continuous flow system, which is a probability distribution function that describes the amount of time a molecule or compound can spend within a reactor setup.

[0020] The terms "halogen" and "halo" are used interchangeably herein and refer to F, Cl, Br, or I.

[0021] The term "alkyl" refers to a saturated straight- or branched-chain monovalent hydrocarbon group. In one example, an alkyl group has 1 to 18 carbon atoms (C 1-18 In other examples, the alkyl group is C 1-12 , C 1-10 , C 1-8 , C 1-6 , C 1-5 , C 1-4 , or C 1-3 Examples of alkyl groups are methyl (Me, -CH3), ethyl (Et, -CH2CH3), 1-propyl (n-Pr, n-propyl, -CH2CH2CH3), 2-propyl (i-Pr, i-propyl, -CH(CH3)2), 1-butyl (n-Bu, n-butyl, -CH2CH2CH2CH3), 2-methyl-1-propyl (i-Bu, i-butyl, -CH2CH(CH3)2), 2-butyl (s-Bu, s-butyl, -CH(C H3)CH2CH3), 2-methyl-2-propyl (t-Bu, t-butyl, -C(CH3)3), 1-pentyl (n-pentyl, -CH2CH2CH2CH2CH3), 2-pentyl (-CH(CH3)CH2CH2CH3), 3-pentyl (-CH(CH2CH3)2), 2-methyl-2-butyl (-C(CH3)2CH2CH3), 3-methyl-2-butyl (-CH(CH3)CH(CH3)2), 3-methyl-1-butyl ( -CH2CH2CH(CH3)2), 2-methyl-1-butyl (-CH2CH(CH3)CH2CH3), 1-hexyl (-CH2CH2CH2CH2CH2CH2CH3), 2-hexyl (-CH(CH3)CH2CH2CH2CH2CH3), 3-hexyl (-CH(CH2CH3)(CH2CH2CH3)), 2-methyl-2-pentyl (-C(CH3)2CH2CH2CH3), 3-methyl-2-pentyl (-CH(CH3)CH(CH 3)CH2CH3), 4-methyl-2-pentyl (-CH(CH3)CH2CH(CH3)2), 3-methyl-3-pentyl (-C(CH3)(CH2CH3)2), 2-methyl-3-pentyl (-CH(CH2CH3)CH(CH3)2), 2,3-dimethyl-2-butyl (-C(CH3)2CH(CH3)2), 3,3-dimethyl-2-butyl (-CH(CH3)C(CH3)3, 1-heptyl, and 1-octyl.

[0022] The term "haloalkyl" refers to an alkyl chain in which one or more hydrogens have been replaced by halogen. Examples of haloalkyl include trifluoromethyl, difluoromethyl, and fluoromethyl. "Fluoroalkyl" refers to an alkyl chain in which one or more hydrogens have been replaced by F.

[0023] The term "amino" means --NH.sub.2.

[0024] The terms "cyano" and "nitrile" are used interchangeably herein to refer to -C≡N or -CN.

[0025] The term "cyanoalkyl" means an alkyl substituted with one cyano substituent.

[0026] The term "hydroxy" means --OH.

[0027] "Fused" means any cyclic structure described herein that shares one or more atoms (e.g., carbon or nitrogen atoms) with an existing cyclic structure in the compounds of the invention.

[0028] As used herein, "halogenating agent" refers to any reagent that adds one or more halogens to a compound described herein. As used herein, "chlorinating agent" refers to any reagent that adds one or more chlorine (Cl) atoms to a compound described herein. In one embodiment, the chlorinating agent is NCS or DCH as described herein. As used herein, "brominating" or "iodinating" agent refers to any reagent that adds one or more bromine (Br) or iodine (I) atoms, respectively, to a compound described herein.

[0029] As used herein, "haloalkylating agent" refers to any reagent that adds one or more haloalkyl groups (e.g., CF) to a compound described herein. "Fluoroalkylating agent" refers to a reagent that adds one or more fluoroalkyl groups to a compound described herein.

[0030] An "organomagnesium compound" is an organometallic compound in which the metal is magnesium.

[0031] The compounds of the present invention may contain one or more chiral carbon atoms. Therefore, the compounds may exist as diastereomers, enantiomers, or mixtures thereof. The synthesis of the compounds may use racemates, diastereomers, or enantiomers as starting materials or intermediates. A mixture of specific diastereomeric compounds may be separated or enriched into one or more specific diastereomers by chromatographic or crystallization methods. Similarly, enantiomeric mixtures may be separated or enantiomerically enriched using the same techniques, or other techniques known in the art. Each asymmetric carbon or nitrogen atom may exist in either the R or S configuration, and both of these configurations are within the scope of the present invention.

[0032] In the structures depicted herein, when the stereochemistry of any particular chiral atom is not specified, all stereoisomers are contemplated and included as compounds of the present invention. When stereochemistry is specified by a solid wedge or dashed line representing a particular configuration, that stereoisomer is so specified and defined. Unless otherwise indicated, when a solid wedge or dashed line is used, relative stereochemistry is intended.

[0033] The term "stereoisomers" means compounds that have identical chemical constitution, but differ with regard to the arrangement of the atoms or groups in space. Stereoisomers include diastereomers, enantiomers, atropisomers, conformers, etc.

[0034] The term "chiral" refers to molecules that possess the property of being non-superimposable on their mirror image partners, while the term "achiral" refers to molecules that are superimposable on their mirror image partners.

[0035] The term "diastereomer" refers to a stereoisomer with two or more chiral centers and whose molecules are not mirror images of one another. Diastereomers have different physical properties, such as melting points, boiling points, spectroscopic properties, or biological activity. Mixtures of diastereomers may separate under high-resolution analytical procedures such as electrophoresis and chromatography such as HPLC.

[0036] The term "enantiomers" refers to two stereoisomers of a compound which are non-superimposable mirror images of one another.

[0037] "Atropisomers" are stereoisomers resulting from sterically hindered rotation about a single bond or axis, where the energy difference due to steric strain or other factors creates a barrier to rotation high enough to allow isolation of individual conformers.

[0038] Stereochemical definitions and conventions used herein generally follow S.P. Parker, Ed., McGraw-Hill Dictionary of Chemical Terms (1984), McGraw-Hill Book Company, New York, and Eliel, E. and Wilen, S., "Stereochemistry of Organic Compounds," John Wiley & Sons, Inc., New York, 1994. Many organic compounds exist in optically active forms, i.e., they have the ability to rotate the plane of plane-polarized light. In describing optically active compounds, the prefixes D and L, or R and S, are used to denote the absolute configuration of the molecule about its chiral center(s). The prefixes d and l, or (+) and (-), are used to denote the sign of rotation of plane-polarized light by the compound, with (-) or l meaning that the compound is levorotatory. Compounds with the prefix (+) or d are dextrorotatory. For a given chemical structure, these stereoisomers are identical except that they are mirror images of each other. A specific stereoisomer may also be referred to as an enantiomer, and a mixture of such isomers is often called an enantiomeric mixture. A 50:50 mixture of enantiomers is called a racemic mixture or racemate, which may occur where there has been no stereoselection or stereospecificity in a chemical reaction or process. The terms "racemic mixture" and "racemate" refer to an equimolar mixture of two enantiomeric species, devoid of optical activity.

[0039] The term "tautomer" or "tautomeric form" means structural isomers with different energies that are interconvertible via a low energy barrier. For example, proton tautomers (also known as prototropic tautomers) include interconversions via migration of a proton, such as keto-enol and imine-enamine isomerizations. Valence tautomers include interconversions via reorganization of some of the bonding electrons.

[0040] As used herein, the term "amino-protecting group" refers to a derivative of a group commonly used to block or protect an amino group, while the reaction is carried out at another functional group in the compound. Examples of such protecting groups include carbamates, amides, alkyl and aryl groups, and imines, as well as many N-heteroatom derivatives that can be removed to regenerate the desired amine group. Specific amino-protecting groups are PMB (p-methoxybenzyl), Boc (tert-butyloxycarbonyl), Fmoc (9-fluorenylmethyloxycarbonyl), Cbz (carbobenzyloxy), Ac (acetyl), trifluoroacetyl, phthalimide, Bn (benzyl), Tr (triphenylmethyl or trityl), benzylidenyl, p-toluenesulfonyl, or DMB (dimethoxybenzyl). In some embodiments, the amino-protecting group may result from cyclization of a group attached to the amino group, but may be a group used to block or protect the amino group that can be subsequently removed or replaced. Such examples include 1,3,5-dioxazinane, 2,4-dimethyl-1,3,5-dioxazinane, 2,2,5,5-tetramethyl-1,2,5-azadisilolidine, and isoindoline-1,3-dione. Further exemplary amino protecting groups are described in T.W. Greene and P.G.M.Wuts, "Protecting Groups in Organic Synthesis, Vol. 3 版 , John Wiley & Sons, Inc., 1999. The term "protected amino" means an amino group substituted with one of the amino-protecting groups described above.

[0041] The term "leaving group" refers to a portion of a first reactant in a chemical reaction that is displaced from that first reactant. Examples of leaving groups include, but are not limited to, halogen atoms, alkoxy, and sulfonyloxy groups. Exemplary sulfonyloxy groups include, but are not limited to, alkylsulfonyloxy groups (e.g., methylsulfonyloxy (mesylate group) and trifluoromethylsulfonyloxy (triflate group)), and arylsulfonyloxy groups (e.g., p-toluenesulfonyloxy (tosylate group) and p-nitrosulfonyloxy (nosylate group)).

[0042] The terms "inhibit" and "reduce / diminish," or any variation of these terms, include any measurable reduction / decrease or complete inhibition to achieve a desired result. For example, there may be a decrease in activity compared to normal of about, up to about, or at least about 5%, 10%, 15%, 20%, 25%, 30%, 35%, 40%, 45%, 50%, 55%, 60%, 65%, 70%, 75%, 80%, 85%, 90%, 95%, 99%, or more, or any variable of these ranges.

[0043] The terms "antagonist" and "inhibitor" are used interchangeably to refer to compounds capable of inhibiting the biological function of a target protein, whether by inhibiting the activity or expression of a protein such as K-Ras, H-Ras, or N-Ras G12C. Thus, the terms "antagonist" and "inhibitor" are defined in the context of the biological role of the target protein. While preferred antagonists herein specifically interact with (e.g., bind to) the target, compounds that inhibit the biological activity of a target protein by interacting with other elements of a signal transduction pathway of which the target protein is a component are also specifically included within this definition. A preferred biological activity inhibited by an antagonist is associated with tumor progression, growth, or spread.

[0044] As used herein, the term "agonist" refers to a compound that has the ability to initiate or enhance the biological function of a target protein, whether by inhibiting the activity or expression of the target protein. Thus, the term "agonist" is defined in the context of the biological role of the target polypeptide. While preferred agonists herein specifically interact with the target (e.g., bind to the target), compounds that initiate or enhance the biological activity of the target polypeptide by interacting with other elements of the signal transduction pathway of which the target polypeptide is a component are also specifically included within this definition.

[0045] The terms "cancer," "cancerous," "neoplasm," and "tumor," as well as related terms, refer to or describe a physiological condition in mammals that is typically characterized by unregulated cell growth. A "tumor" contains one or more cancerous cells. Examples of cancers include carcinoma, blastoma, sarcoma, seminoma, glioblastoma, melanoma, leukemia, and myeloid or lymphoid malignancies. More specific examples of such cancers include squamous cell carcinomas (e.g., epithelial squamous cell carcinoma) and lung cancers (such as small cell lung cancer, non-small cell lung cancer ("NSCLC"), lung adenocarcinoma, and lung squamous cell carcinoma). Other cancers include skin cancer, keratoacanthoma, follicular carcinoma, hairy cell leukemia, oral cavity cancer, pharyngeal (mouth) cancer, lip cancer, tongue cancer, mouth cancer, salivary gland cancer, esophageal cancer, laryngeal cancer, hepatocellular carcinoma, gastric cancer, stomach cancer, gastrointestinal cancer, small intestine cancer, colon cancer, pancreatic cancer, cervical cancer, ovarian cancer, liver cancer, bladder cancer, liver cancer, breast cancer, colon cancer, rectal cancer, colorectal cancer, genitourinary cancer, biliary tract cancer, thyroid cancer, papillary cancer, liver cancer, uterine cancer, uterine cancer, salivary gland cancer, kidney or renal cancer, prostate cancer, testicular cancer, vulvar cancer, peritoneal cancer, anal cancer, penile cancer, bone cancer, multiple myeloma, B-cell lymphoma, diffuse large B-cell lymphoma (DLBCL), central nervous system, brain cancer, head and neck cancer, Hodgkin's disease, and related metastases. Examples of neoplastic disorders include myeloproliferative disorders such as polycythemia vera, essential thrombocytosis, myelofibroses such as primary myelofibrosis, and chronic myelogenous leukemia (CML).

[0046] A "chemotherapeutic agent" is an agent useful for treating a given disorder, such as cancer or an inflammatory disorder. Examples of chemotherapeutic agents are known in the art, and include, for example, those disclosed in U.S. Patent Application Publication No. 2010 / 0048557, which is incorporated herein by reference. Additionally, chemotherapeutic agents include any pharmaceutically acceptable salt, acid, or derivative of a chemotherapeutic agent, and combinations of two or more thereof.

[0047] The term "treatment" refers to a clinical intervention designed to alter the natural course of the patient or cells being treated during the course of clinical disease. Desirable effects of treatment include reducing the rate of disease progression, ameliorating or alleviating the disease state, and ameliorating or improving prognosis. For example, a patient is successfully "treated" if one or more symptoms associated with breast cancer described herein are alleviated or eliminated, including, but not limited to, reducing (or destroying) the proliferation of cancer cells, reducing symptoms caused by the disease, improving the quality of life of those suffering from the disease, reducing the dose of other drugs required to treat the disease, and / or extending the patient's survival.

[0048] The term "delaying progression" of a disease refers to postponing, preventing, slowing, retarding, stabilizing, and / or postponing the development of breast cancer as described herein. This delay can be of varying lengths of time depending on the history of the cancer and / or the patient being treated. As will be appreciated by those skilled in the art, a sufficient or significant delay can, in effect, encompass prevention, in that the patient does not develop cancer.

[0049] An "effective amount" is at least the minimum amount required to effect a measurable improvement or prevention of breast cancer as described herein. The effective amount herein may vary depending on factors such as the patient's disease state, age, sex, and weight, as well as the ability of the agent to elicit a desired response in the patient. An effective amount is also one in which the therapeutically beneficial effects outweigh any toxic or adverse effects of the treatment. Beneficial or desired results include elimination or reduction of risk, alleviation of severity, delay in onset of the disease (including biochemical, histological, and / or behavioral symptoms of the disease, its complications, and intermediate pathological phenotypes manifesting during the development of the disease), reduction of one or more symptoms attributable to the disease, improvement in the quality of life of those suffering from the disease, reduction in the dose of other drugs required to treat the disease, enhancement of the effect of another drug by targeting or otherwise, delay in disease progression, and / or prolongation of survival, etc. In some embodiments, an effective amount of a drug may be effective in reducing the number of cancer cells; shrinking tumor size; inhibiting (i.e., slowing or stopping) cancer cell invasion into peripheral organs; inhibiting (i.e., slowing or stopping) tumor metastasis; inhibiting (i.e., slowing or stopping) tumor growth; and / or alleviating one or more symptoms associated with a disorder. An effective amount may be administered in one or more administrations. An effective amount of a drug, compound, pharmaceutical composition, or combination therapy described herein may be an amount sufficient to directly or indirectly achieve therapeutic treatment. As clinically understood, an effective amount of a drug, compound, or pharmaceutical composition may or may not be achieved in combination with another drug, compound, or pharmaceutical composition or combination therapy. Thus, an "effective amount" may be considered in the context of administering one or more therapeutic agents, and a single agent may be considered to be administered in an effective amount if, in combination with one or more other agents, a desired result is obtained or achieved.

[0050] It is specifically contemplated that any limitation discussed with respect to one embodiment of the invention may also apply to any other embodiment of the invention. Furthermore, any compound or composition of the invention may be used in any method of the invention, and any method of the invention may be used to produce or utilize any compound or composition of the invention.

[0051] Throughout this application, the term "about" is used to indicate that a value includes the standard deviation of error for the device or method being employed to measure the value.

[0052] Formula (I): Provided herein are methods for synthesizing a compound of TIFF2026016384000003.tif52170, or a solvate, tautomer, stereoisomer, atropisomer, or salt thereof.

[0053] In one embodiment, a compound of formula (I): TIFF2026016384000004.tif52170(in the formula, 1 and X 3 are each independently hydrogen or halogen; R 1 is hydrogen or PG 1 and; Each R 2 are independently selected from halogen, cyano, and unsubstituted C 1-6 Alkyl, unsubstituted C 1-6 Cyanoalkyl, or unsubstituted C 1-6 is haloalkyl; R 3 is hydrogen, halogen, R 3A -substituted or unsubstituted C 1-3 Alkyl, R 3A -substituted or unsubstituted C 1-3 Haloalkyl, or R 3A -substituted or unsubstituted cyclopropyl; R 3A is halogen, OH, CN, unsubstituted C 1-3 Alkyl or unsubstituted C 1-3 is haloalkyl; R 4 is R 4A -substituted or unsubstituted C 1-3 is haloalkyl; R 4A is the unsubstituted C 1-3 is alkyl; n is 1 or 2; each PG is independently an amino protecting group; PG 1 is an amino protecting group), or a solvate, tautomer, stereoisomer, atropisomer or salt thereof, comprising: This method is (a) Formula (II) TIFF2026016384000005.tif43170(in the formula, 2 is a halogen) with an organomagnesium compound, thereby forming a compound of formula (IIa): forming a compound of formula TIFF2026016384000006.tif47170 (IIa); (b) transferring the compound of formula (IIa) from step (a) to a continuous stirred tank reactor (CSTR) containing a zinc compound, thereby producing a compound of formula (IIb): TIFF2026016384000007.tif45170 (wherein m is 0, 1, or 2; p is 1, 2 or 3; X 2 is a halogen or OPiv; (c) reacting compound (IIb) of step (b) with a compound of formula (III) TIFF2026016384000008.tif27170(in the formula, 4 is a halogen), There is provided a process (P1) for synthesizing a compound of formula (I), or a solvate, tautomer, stereoisomer, atropisomer, or salt thereof, comprising contacting a transition metal catalyst precursor, and a chiral ligand, thereby synthesizing the compound of formula (I).

[0054] In one embodiment, X1 is a halogen. In one such embodiment, X 1 is F or Cl. In one embodiment, X 3 is a halogen. In one such embodiment, X 3 is F or Cl. In another embodiment, X 1 and X 3 are each independently a halogen. In one such embodiment, X 1 is F and X 3 is a halogen. In one such embodiment, X 3 is Cl and X 1 is a halogen. In one such embodiment, X 1 is F and X 3 is Cl.

[0055] In one embodiment, the compound of formula (IIb) is: TIFF2026016384000009.tif48170(in the formula, 1 , X 2 , X 3 , R 1 , R 2 and n is as defined herein).

[0056] In one embodiment, X 2 is Cl, Br or OPiv. In one embodiment, X 2 is Cl or Br. In one embodiment, X 2 is Br. In one embodiment, X 2 is Cl.

[0057] In one embodiment of the compound of Formula (IIb), X 2 is Cl, m is 1 or 2, and p is 1. In one embodiment of the compound of Formula (IIb), X 2 is Cl, m is 1 or 2, and p is 2. In one embodiment of the compound of Formula (IIb), X 2 is Cl, m is 1 or 2, and p is 3.

[0058] In one embodiment of the compound of Formula (IIb), X2 is Cl, m is 0, and p is 2. In one embodiment of the compound of Formula (IIb), X 2 is Cl, m is 0, and p is 3.

[0059] In one embodiment of the compound of Formula (IIb), X 2 is Cl, m is 1, and p is 1. In one embodiment of the compound of Formula (IIb), X 2 is Cl, m is 1 and p is 2. In one embodiment of the compound of Formula (IIb), X 2 is Cl, m is 1, and p is 3.

[0060] In one embodiment of the compound of Formula (IIb), X 2 is Cl, m is 2, and p is 1. In one embodiment of the compound of Formula (IIb), X 2 is Cl, m is 2, and p is 2. In one embodiment of the compound of Formula (IIb), X 2 is Cl, m is 2, and p is 3.

[0061] In one embodiment of the compound of Formula (IIb), X 2 is Br, m is 1 or 2, and p is 1. In one embodiment of the compound of formula (IIb), X 2 is Br, m is 1 or 2, and p is 2. In one embodiment of the compound of formula (IIb), X 2 is Br, m is 1 or 2, and p is 3.

[0062] In one embodiment of the compound of Formula (IIb), X 2 is Br, m is 0, and p is 2. In one embodiment of the compound of Formula (IIb), X 2 is Br, m is 0, and p is 3.

[0063] In one embodiment of the compound of Formula (IIb), X 2 is Br, m is 1, and p is 1. In one embodiment of the compound of Formula (IIb), X 2is Br, m is 1, and p is 2. In one embodiment of the compound of Formula (IIb), X 2 is Cl, m is 1, and p is 3.

[0064] In one embodiment of the compound of Formula (IIb), X 2 is Br, m is 2, and p is 1. In one embodiment of the compound of Formula (IIb), X 2 is Br, m is 2, and p is 2. In one embodiment of the compound of Formula (IIb), X 2 is Br, m is 2, and p is 3.

[0065] In one embodiment of the compound of Formula (IIb), X 2 is OPiv, m is 1 or 2, and p is 1. In one embodiment of the compound of formula (IIb), X 2 is OPiv, m is 1 or 2, and p is 2. In one embodiment of the compound of formula (IIb), X 2 is OPiv, m is 1 or 2, and p is 3.

[0066] In one embodiment of the compound of Formula (IIb), X 2 is OPiv, m is 0 and p is 2. In one embodiment of the compound of formula (IIb), X 2 is OPiv, m is 0, and p is 3.

[0067] In one embodiment of the compound of Formula (IIb), X 2 is OPiv, m is 1 and p is 1. In one embodiment of the compound of formula (IIb), X 2 is OPiv, m is 1 and p is 2. In one embodiment of the compound of formula (IIb), X 2 is OPiv, m is 1, and p is 3.

[0068] In one embodiment of the compound of Formula (IIb), X 2 is OPiv, m is 2, and p is 1. In one embodiment of the compound of formula (IIb), X 2is OPiv, m is 2, and p is 2. In one embodiment of the compound of formula (IIb), X 2 is OPiv, m is 2, and p is 3.

[0069] In another embodiment, the compound of formula (IIb) has the formula: TIFF2026016384000010.tif43170, where p and m are as described herein. In one embodiment, when the zinc compound contains Cl, X 2 is Cl. In one embodiment, when the zinc compound comprises OPiv, X 2 is OPiv. In one embodiment, compound 2b is 2 , m, and p are different. In one embodiment, compound 2b comprises at least two or three different species. In one such embodiment, such species can be interconverted.

[0070] In one embodiment, R 1 is PG 1 and PG 1 In one such embodiment, PG 1 is Ac (acetyl), trifluoroacetyl, Bn (benzyl), Tr (triphenylmethyl or trityl), benzylidenyl, p-toluenesulfonyl, PMB (p-methoxybenzyl), Boc (tert-butyloxycarbonyl), Fmoc (9-fluorenylmethyloxycarbonyl), or Cbz (carbobenzyloxy). In one embodiment, PG 1 is an acid-labile amino protecting group. In one embodiment, PG 1 is tert-butyloxycarbonyl (Boc).

[0071] In one embodiment, each R 2 is independently halogen or cyano. In another such embodiment, each R 2 are independently unsubstituted C 1-6 Alkyl, unsubstituted C 1-6 Cyanoalkyl, or unsubstituted C 1-6haloalkyl. In one embodiment, each R 2 are independently unsubstituted C 1-3 In one such embodiment, each R 2 is independently methyl or ethyl. In one embodiment, each R 2 is independently methyl. In one such embodiment, R 2 is methyl and n is 1. In one such embodiment, each R 2 is independently methyl or ethyl, and n is 1. In another embodiment, each R 2 are independently unsubstituted C 1-3 Cyanoalkyl or unsubstituted C 1-3 In one such embodiment, the unsubstituted C 1-6 Cyanoalkyl, or unsubstituted C 1-6 haloalkylCHF, CHF, CF, CHCHF, CHCHF, CHCF, CHCN, or CHCHCN. In one such embodiment, unsubstituted C 1-6 Cyanoalkyl or unsubstituted C 1-6 haloalkylCHF, CHF, CF, CHCHF, CHCHF, CHCF, CHCN, or CHCHCN, where n is 1. In one embodiment, R 2 is the unsubstituted C 1-6 Alkyl or unsubstituted C 1-6 It is a cyanoalkyl.

[0072] In one embodiment, R 3 is hydrogen, halogen, or R 3A -substituted or unsubstituted C 1-3 In one embodiment, R 3 is R 3A -substituted or unsubstituted C 1-3 Haloalkyl, or R 3A In one embodiment, R 3 is hydrogen or R 3A Substituted or unsubstituted C 1-3 In one embodiment, R 3 is hydrogen or methyl. In one embodiment, R3 is methyl. In one embodiment, R 3 is hydrogen and R 4 is CF3. In another embodiment, R 3 is methyl and R 4 is CF3.

[0073] In one embodiment, R 4 is CF3, CHF2 or CH2F.

[0074] In one embodiment, each PG is independently a protecting group selected from the group consisting of Ac (acetyl), trifluoroacetyl, phthalimide, Bn (benzyl), Tr (triphenylmethyl or trityl), benzylidenyl, p-toluenesulfonyl, DMB (dimethoxybenzyl), PMB (p-methoxybenzyl), Boc (tert-butyloxycarbonyl), Fmoc (9-fluorenylmethyloxycarbonyl), or Cbz (carbobenzyloxy). In one embodiment, each PG is the same. When each PG is the same, in one such embodiment, each PG is PMB.

[0075] The organomagnesium compound can be, for example, a Grignard reagent. In one embodiment, the organomagnesium compound is selected from the group consisting of isopropylmagnesium chloride, isopropylmagnesium bromide, isopropylmagnesium iodide, isopropylmagnesium chloride lithium chloride complex, sec-butylmagnesium chloride, lithium tri-n-butylmagnesiate, lithium triisopropylmagnesiate, and lithium (isopropyl)(di-n-butyl)magnesiate. In one embodiment, the organomagnesium compound of the methods described herein is i-PrMgCl·LiCl.

[0076] In the methods described herein, the Zn compound is selected from the group consisting of ZnCl, ZnBr, ZnI, Zn(TFA), Zn(OAc), and Zn(OPiv), including LiCl or LiTFA salts. In one embodiment, the Zn compound is ZnCl, ZnBr, or ZnI. In one embodiment, the Zn compound is ZnCl, ZnBr, or Zn(OPiv). In one embodiment, the Zn compound is ZnCl or Zn(OPiv). In one embodiment, the Zn compound is ZnCl. In one embodiment, the Zn compound is ZnCl·LiCl. In one embodiment, the Zn compound is Zn(OPiv). In one embodiment, the Zn compound is a salt, Zn(OPiv)·LiCl.

[0077] In one embodiment, the transition metal catalyst precursor is a Pd or Ni catalyst precursor. In one embodiment, the transition metal catalyst precursor is a Pd or Ni catalyst precursor, and is selected from Pd(OAc), PdCl, PdCl(MeCN), Pd(benzonitrile), and Pd(OAc). 2、 and selected from the group consisting of Pd(dba)2, Pd2(dba)3, Pd(PPh3)4, Pd(PCy3)2, Pd(PtBu3)2, Pd(TFA)2, [Pd(allyl)Cl]2, [Pd(cinnamyl)Cl]2, [PdCl(crotyl)]2, PdCl(η5-cyclopentadienyl), [(η3-allyl)(η5-cyclopentadienyl)palladium(II)], [Ni(η5-cyclopentadienyl)(allyl)], [bis(1,5-cyclooctadiene)nickel(0)], NiCl2, NiBr2, Ni(OAc)2, and nickel(II) acetylacetonate.

[0078] In one such embodiment of the method (P1) described herein, the Pd or Ni catalyst precursor is a Pd catalyst precursor. In one embodiment, the Pd catalyst precursor is Pd(OAc) 2 , PdCl 2 , PdCl 2 (MeCN) 2 , Pd(dba) 2 , Pd(dba) 3 , Pd(TFA) 2 , [Pd(allyl)Cl] 2 , [Pd(cinnamyl)Cl] 2 , [PdCl(crotyl)] 2 , PdCl(η-cyclopentadienyl), or [(η-allyl)(η-cyclopentadienyl)palladium(II)]. In another embodiment of the method (P1) described herein, the Pd catalyst precursor is Pd(OAc) 2 or PdCl 2 . In another embodiment of method (P1) described herein, the Pd catalyst precursor is [PdCl(crotyl)], PdCl(η-cyclopentadienyl), PdCl(MeCN), Pd(dba), Pd(dba), or Pd(TFA). In another embodiment of method (P1) described herein, the Pd catalyst precursor is [Pd(allyl)Cl], [Pd(cinnamyl)Cl], or (η-allyl)(η-cyclopentadienyl)palladium(II). In one embodiment, the Pd catalyst precursor is [Pd(allyl)Cl] or [Pd(cinnamyl)Cl]. In one embodiment, the Pd catalyst precursor is [Pd(cinnamyl)Cl].

[0079] In another embodiment of method (P1) described herein, the Pd or Ni catalyst precursor is a Ni catalyst precursor. In one embodiment, the Ni catalyst precursor is NiCp(allyl), bis(1,5-cyclooctadiene)nickel(0), NiCl, NiBr, Ni(OAc), or nickel(II) acetylacetonate. In one embodiment, the Ni catalyst precursor is NiCl, NiBr, or Ni(OAc). In another embodiment, the Ni catalyst precursor is NiCp(allyl), bis(1,5-cyclooctadiene)nickel(0), or nickel(II) acetylacetonate.

[0080] In one embodiment of method (P1) described herein, a Pd precursor described herein and a chiral ligand described herein are contacted to form a Pd-ligand complex in situ. In another embodiment, a Pd precursor described herein is treated with a chiral ligand described herein to form a Pd-ligand complex, which may be isolated prior to use in the methods described herein. In one embodiment, the Pd catalyst precursor is [Pd(cinnamyl)Cl]2 and the zinc compound is ZnCl2 or Zn(OPiv)2.

[0081] In one embodiment, the chiral ligand has the formula: TIFF2026016384000011.tif47170 (in the formula, Y is O or NR 7 and; R 7 and R 8 are independently unsubstituted C 1-6 It is a compound of the formula (wherein the alkyl is alkyl).

[0082] In one embodiment of the compound of formula L1, R 7 and R 8 In one such embodiment, R 7 and R 8 are each independently methyl, ethyl, or phenyl. 7 and R 8 are each methyl (e.g., (R,R)-chiraphite). In one embodiment, R 7 and R 8 are each ethyl. In one embodiment of the methods described herein, the chiral ligand is (R,R)-chiraphite.

[0083] In one embodiment of Process (P1) described herein, step (a) is carried out using a pre-cooled solution comprising a compound of Formula (II) described herein and an organomagnesium compound described herein, respectively. In one such embodiment, the pre-cooling temperature is about -30°C to about 20°C; -30°C to about 15°C; -30°C to about 10°C; -30°C to about 5°C; -30°C to about 0°C; -25°C to about 20°C; -25°C to about 15°C; -25°C to about 10°C; -25°C to about 5°C; -25°C to about 0°C; -20°C to about 20°C; -20°C to about 15°C; -20°C to about 10°C; -20°C to about 5°C; or -20°C to about 0°C. In one embodiment, the compound of Formula (IIb) is isolated (and optionally stored) prior to step (b). In one such embodiment, the compound of formula (IIa) is stable for at least 1, 2, 3, 4, 5, or 6 weeks.

[0084] In one embodiment, the organomagnesium compound described herein has a magnesium ion concentration of about 0.9 to 1.50; 0.9 to 1.45; 0.9 to 1.40; 0.9 to 1.35; 0.9 to 1.30; 0.9 to 1.25; 0.9 to 1.20; 0.9 to 1.15; 0.9 to 1.10; 0.9 to 1.05; 0.9 to 1.02; 0.9 to 1.00; 0.95 to 1.50; 0.95 to 1.45; 0.95 to 1.40; 0.95 to 1.35; 0.95 to 1.30; 0.9 Present in molar equivalents of 5 to 1.25; 0.95 to 1.20; 0.95 to 1.15; 0.95 to 1.10; 0.95 to 1.08; 0.95 to 1.05; 0.95 to 1.03; 0.95 to 1.02; 0.95 to 1.01; 0.95 to 1.00; 1.00 to 1.15; 1.00 to 1.12; 1.00 to 1.11; 1.00 to 1.10; 1.00 to 1.09; 1.00 to 1.08; 1.00 to 1.07; 1.00 to 1.06; 1.00 to 1.05; 1.00 to 1.03; or 1.00 to 1.02.

[0085] In one embodiment of method (P1) described herein, step (b) is carried out at about -30°C to about 20°C; -30°C to about 15°C; -30°C to about 10°C; -30°C to about 5°C; -30°C to about 0°C; -25°C to about 20°C; -25°C to about 15°C; -25°C to about 10°C; -25°C to about 5°C; -25°C to about 0°C; -20°C to about 20°C; -20°C to about 15°C; -20°C to about 10°C; -20°C to about 5°C; or -20°C to about 0°C. In one embodiment of method (P1) described herein, step (b) is carried out at about -30°C, -25°C, -20°C, -15°C, -10°C, -5°C, 0°C, 5°C, or 10°C. In one such embodiment, step (b) is carried out at a temperature of about -5°C, 0°C or 5°C.

[0086] In one embodiment, the Zn compound described herein is present in an amount of about 0.3-1.50, 0.3-1.45, 0.3-1.40, 0.3-1.35; 0.3-1.30; 0.3-1.25; 0.3-1.20; 0.3-1.15; 0.3-1.10; 0.3-1.05; 0.3-1.02; 0.3-1.00; 0.3-0.95, 0.3-0.90, 0.3-0.8, 0.3-0.75, or 0.3-0.6 molar equivalents relative to the compound of Formula (IIa) in step (a) of method (P1). In one embodiment, the Zn compound described herein is present in an amount of about 0.4-1.50, 0.4-1.45, 0.4-1.40, 0.4-1.35; 0.4-1.30; 0.4-1.25; 0.4-1.20; 0.4-1.15; 0.4-1.10; 0.4-1.05; 0.4-1.02; 0.4-1.00; 0.4-0.95, or 0.4-0.90 molar equivalents relative to the compound of Formula (IIa) in step (a) of method (P1).

[0087] In one embodiment, the Zn compound described herein is present in an amount of about 0.6-1.75, 0.6-1.70, 0.6-1.65, 0.6-1.60, 0.6-1.55, 0.6-1.50, 0.6-1.45, 0.6-1.40, 0.6-1.35; 0.6-1.30; 0.6-1.25; 0.6-1.20; 0.6-1.15; 0.6-1.10; 0.6-1.05; 0.6-1.02; 0.6-1.00; 0.6-0.95, or 0.6-0.90 molar equivalents relative to the compound of Formula (IIa) in step (a) of method (P1). In one embodiment, the Zn compound described herein is present in an amount of about 0.3-0.6, 0.6-0.9, or 0.9-1.5 molar equivalents relative to the compound of Formula (IIa) in step (a) of process (P1). In one embodiment, the Zn compound described herein is present in an amount of about 0.3-0.6 or 0.6-0.9 molar equivalents relative to the compound of Formula (IIa) in step (a) of process (P1).

[0088] In one embodiment, the Zn compound described herein is present in an amount of 0.95 to 1.50; 0.95 to 1.45; 0.95 to 1.40; 0.95 to 1.35; 0.95 to 1.30; 0.95 to 1.25; 0.95 to 1.20; 0.95 to 1.15; 0.95 to 1.10; 0.95 to 1.08; 0.95 to 1.05; 0.95 to 1.08; 0.95 to 1.05; 0.95 to 1.15; 0.95 to 1.20; 0.95 to 1.30; 0.95 to 1.40; 0.95 to 1.40; 0.95 to 1.30; 0.95 to 1.30; 0.95 to 1.40; 0.95 to 1.40; 0.95 to 1.50; 0.95 to 1.30; 0.95 to 1.30; 0.95 to 1.20; 0.95 to 1.15; 0.95 to 1.10; 0.95 to 1.08; 0.95 to 1.05 ...05; 0.95 to 1.05; 0.95 to 1.05; 0.95 to 1.05; 0.95 to 1.05; 0. Present in molar equivalents of 0.95 to 1.03; 0.95 to 1.02; 0.95 to 1.01; 0.95 to 1.00; 1.00 to 1.15; 1.00 to 1.12; 1.00 to 1.11; 1.00 to 1.10; 1.00 to 1.09; 1.00 to 1.08; 1.00 to 1.07; 1.00 to 1.06; 1.00 to 1.05; 1.00 to 1.03; or 1.00 to 1.02.

[0089] In one embodiment, the Zn compound described herein is present in an amount of about 0.9 to 1.75, 0.9 to 1.70, 0.9 to 1.65, 0.9 to 1.60, 0.9 to 1.55, 0.9 to 1.50, 0.9 to 1.45, 0.9 to 1.40, 0.9 to 1.35; 0.9 to 1.30; 0.9 to 1.25; 0.9 to 1.20; 0.9 to 1.15; 0.9 to 1.10; 0.9 to 1.05; 0.9 to 1.02; 0.9 to 1.00; 0.95 to 1.50; 0.95 to 1.45; 0.95 to 1.40; 0.95 ~1.35; 0.95-1.30; 0.95-1.25; 0.95-1.20; 0.95-1.15; 0.95-1.10; 0.95-1.08; 0.95-1.05; 0.95-1.03; 0.95-1.02; 0.95-1.01; 0.95-1.00; 1.00-1.15; 1.00-1.12; 1.00-1.11; 1.00-1.10; 1.00-1.09; 1.00-1.08; 1.00-1.07; 1.00-1.06; 1.00-1.05; 1.00-1.03; or 1.00-1.02 molar equivalents. In one embodiment, the compound of Formula (IIb) is stable in solution under inert conditions for at least 1, 2, 3, 4, 5, or 6 weeks.

[0090] In one embodiment, the compound of formula (III) described herein has a molar ratio of about 0.9 to 1.50; 0.9 to 1.45; 0.9 to 1.40; 0.9 to 1.35; 0.9 to 1.30; 0.9 to 1.25; 0.9 to 1.20; 0.9 to 1.15; 0.9 to 1.10; 0.9 to 1.05; 0.9 to 1.02; 0.9 to 1.00; 0.95 to 1.50; 0.95 to 1.45; 0.95 to 1.40; 0.95 to 1.35; 0.95 to 1.30; 0.95 In one embodiment, the compound is present in an amount of from about 1.25; 0.95 to about 1.20; 0.95 to about 1.15; 0.95 to about 1.10; 0.95 to about 1.08; 0.95 to about 1.05; 0.95 to about 1.03; 0.95 to about 1.02; 0.95 to about 1.01; 0.95 to about 1.00; 1.00 to about 1.15; 1.00 to about 1.12; 1.00 to about 1.11; 1.00 to about 1.10; 1.00 to about 1.09; 1.00 to about 1.08; 1.00 to about 1.07; 1.00 to about 1.06; 1.00 to about 1.05; 1.00 to about 1.03; or 1.00 to about 1.02.

[0091] In one embodiment, the compound of formula (II) is (a) In the presence of a base, CO2 reacts with a compound of formula (IV) Compound (V) of TIFF2026016384000012.tif22170 cyclization to compound TIFF2026016384000013.tif23170; (b) contacting the compound of formula (V) with a chlorinating agent, thereby forming a compound of formula (Va) To synthesize the compound TIFF2026016384000014.tif24170; (c) reacting the compound of step (b) with a compound of formula (I) in the presence of a base; TIFF2026016384000015.tif24170, thereby contacting a piperazinyl moiety having formula (Vb) synthesizing the compound TIFF2026016384000016.tif42170; and (d) contacting the compound of step (c) with a fluorinating agent in the presence of a base, thereby synthesizing a compound of formula (II). It is prepared by a method (P2) comprising:

[0092] In one embodiment of method (P2), the base is 1,8-diazabicyclo[5.4.0]undec-7-ene (DBU). In another embodiment, the base is DBN (1,5-diazabicyclo[4.3.0]non-5-ene), MTBD (7-methyl-1,5,7 triazabicyclo(4.4.0)dec-5-ene), or TBD (1,5,7 triazabicyclo(4.4.0)dec-5-ene). In another embodiment, the base is a carbonate base, such as Na2CO3, K2CO3, or Cs2CO3, and the reaction solvent is water, or it can function in water as a solvent.

[0093] In one embodiment of process (P2), the chlorinating agent in step (b) is POCl, PCl, PCl, or SOCl. In one such embodiment, the chlorinating agent in step (b) is POCl.

[0094] In one embodiment of method (P2), the base in step (c) is N-ethylmorpholine (NEM), triethylamine (TEA), tri(n-propyl)amine (TPA), N,N-diisopropylethylamine (DIPEA), N-methylmorpholine (NMM), N-methylimidazole (NMI), DBU, tri(n-butyl)amine, pyridine, 2,6-lutidine, or 2,4,6-collidine. In one embodiment, the base in step (c) is DIPEA. In one embodiment, the base in step (c) is N-ethylmorpholine (NEM), triethylamine (TEA), or tri(n-propyl)amine (TPA). In one embodiment, the base in step (c) is N-methylmorpholine (NMM), N-methylimidazole (NMI), DBU, or tri(n-butyl)amine. In one embodiment, the base in step (c) is pyridine, 2,6-lutidine, or 2,4,6-collidine.

[0095] In another embodiment of Method (P2), the fluorinating agent in step (d) is KF. In another embodiment of Method (P2), the fluorinating agent in step (d) is CsF or NaF. In another embodiment of Method (P2), the base is DABCO (1,4-diazabicyclo[2.2.2]octane). In one such embodiment, DABCO is present in a catalytic amount. In another such embodiment, step (d) of Method (P2) further comprises MsOH as an additive.

[0096] Compound (IV) of method (P2) may be synthesized according to method (P3) described herein, wherein the compound of formula (IV) is (a) Formula (IVa) TIFF2026016384000017.tif18170 is contacted with i-PrMgCl, thereby forming a compound of formula (IVb) To synthesize the compound TIFF2026016384000018.tif19170; (b) contacting the compound of step (a) with hydroxylamine (NHOH), thereby forming a compound of formula (IVc): To synthesize the compound TIFF2026016384000019.tif27170; (c) contacting the compound of step (b) with a base and a dehydrating agent as described herein in acetonitrile, thereby obtaining a compound of formula (IVd): a step of synthesizing the compound of TIFF2026016384000020.tif19170; (d) contacting the compound of step (c) with ammonia, thereby forming a compound of formula (IVe): synthesizing the compound TIFF2026016384000021.tif19170; and (e) contacting the compound of step (d) with a halogenating agent, thereby synthesizing a compound of formula (IV). In one embodiment, the halogenating agent is a chlorinating agent, and X 3 is Cl.

[0097] In one embodiment of method (P3), the base in step (c) is a tertiary amine. In one embodiment, the base in step (c) is N-ethylmorpholine (NEM), triethylamine (TEA), tri(n-propyl)amine (TPA), N,N-diisopropylethylamine (DIPEA), N-methylmorpholine (NMM), N-methylimidazole (NMI), 1,8-diazabicyclo[5.4.0]undec-7-ene (DBU), or tri(n-butyl)amine. In one such embodiment, the base is triethylamine. In another embodiment of method (P3), the base in step (c) is pyridine or DBU. In another embodiment of method (P3), the base in step (c) is an inorganic base, such as KCO, NaOAc, NaOH, or KOH, which can potentially be used.

[0098] In one embodiment of method (P3), the dehydrating agent in step (c) is trifluoroacetic anhydride (TFAA), acetic anhydride (AcO), methanesulfonic anhydride (MsO), p-toluenesulfonic anhydride (TsO), trifluoromethanesulfonic anhydride (TfO), propanephosphonic anhydride (T3P), methanesulfonyl chloride (MsCl), toluenesulfonyl chloride (TsCl), SOCl, POCl, or carbonyldiimidazole (CDI). In one such embodiment, the dehydrating agent is trifluoroacetic anhydride (TFAA) or acetic anhydride (AcO). In one such embodiment, the dehydrating agent in step (c) is trifluoroacetic anhydride (TFAA), acetic anhydride (AcO), methanesulfonic anhydride (MsO), p-toluenesulfonic anhydride (TsO), trifluoromethanesulfonic anhydride (TfO), or propanephosphonic anhydride (T3P). In another such embodiment, the dehydrating agent in step (c) is trifluoroacetic anhydride (TFAA), acetic anhydride (AcO), or trifluoromethanesulfonic anhydride (TfO). In another such embodiment, the dehydrating agent is trifluoroacetic anhydride (TFAA).

[0099] In one embodiment of method (P3), the halogenating agent in step (e) is 1,3-dichloro-5,5-dimethylhydantoin (DCDMH or DCH), SO2Cl2, TCCA (trichloroisocyanuric acid), N-chlorosaccharin, or N-chlorosuccinimide (NCS). In one such embodiment, the halogenating agent is NCS. In one embodiment of method (P3), step (e) further comprises a substoichiometric amount of an acid. In one such embodiment, the acid is HCl.

[0100] In one embodiment of method (P1), the compound of formula (III) is (a)X 6 Formula (VIa) in which is Cl or I TIFF2026016384000022.tif22170 is contacted with a halogenating agent to form a compound of formula (VIb) To form compounds of TIFF2026016384000023.tif22170; (b) brominating a compound of formula (VIb) to form a compound of formula (VI) forming a compound of TIFF2026016384000024.tif19170; and (c) contacting the compound of formula (VI) with a compound having the formula NH(PG)2, thereby producing a compound of formula (III). It is prepared by a method (P4) comprising:

[0101] In one embodiment of method (P4), each X 6 In one embodiment of method (P4), each X 6 is Cl. In one embodiment of process (P4), the halogenating agent in step (a) is SF4 in HF.

[0102] In one embodiment of method (P4), the bromination in step (b) is carried out using HBr in an acid. In one such embodiment, the acid is acetic acid. In another such embodiment, the acid is trifluoroacetic acid.

[0103] In one embodiment of the methods described herein, the compound of formula (III) has the formula: I have TIFF2026016384000025.tif25170.

[0104] In one such embodiment, the compound of formula (III) has the formula: TIFF2026016384000026.tif23170(3). Compound (3) can be synthesized according to the methods described herein (e.g., method (P4)).

[0105] In one such embodiment of method (P1), the compound of formula (III) has formula (3), and the compound of formula (3) is (a) Equation (6a) TIFF2026016384000027.tif19170 is contacted with SF4 and HF, thereby forming a compound of formula (6b) To synthesize the compound TIFF2026016384000028.tif19170; (b) contacting a compound of formula (6b) with HBr in AcOH to form a compound of formula (6): To form compounds of TIFF2026016384000029.tif18170; (c) contacting the compound of formula (6) with NH(PMB) 2 , triethylamine and N-butylpyrrolidinone (NBP), thereby synthesizing the compound of formula (3); It is synthesized by method (P6), which includes

[0106] In one embodiment, the compound of formula (I) has the formula: I have TIFF2026016384000030.tif99170.

[0107] In one embodiment of the compounds of Formula (Ia), (Ib), (Ic) and (Id), R 2 In one embodiment of the compounds of Formula (Ia), (Ib), (Ic) and (Id), X 3 In one such embodiment, X is halo. 3 is Cl.

[0108] In one embodiment, the compound of formula (I) has the formula: TIFF2026016384000031.tif47170(Ie) (where X 3 is a halo).

[0109] In one embodiment, the compound of formula (I) has the formula: It has TIFF2026016384000032.tif47170(11).

[0110] Furthermore, equation (2): Methods for synthesizing the compound of TIFF2026016384000033.tif38170(2) are provided herein.

[0111] In one embodiment, there is provided a method (P5) for synthesizing a compound of formula (2), comprising: (a) Equation (4a) The compound of formula (4c) is contacted with i-PrMgCl and subsequently with hydroxylamine (NHOH), thereby forming a compound of formula (4c) a step of synthesizing the compound of TIFF2026016384000035.tif27170; (b) contacting a compound of formula (4c) with TFAA and triethylamine in acetonitrile, followed by contact with ammonia, thereby producing a compound of formula (4e): a step of synthesizing the compound of TIFF2026016384000036.tif19170; (c) contacting the compound of (4e) with a chlorinating agent, thereby forming a compound of formula (4) A process for synthesizing the compound of TIFF2026016384000037.tif19170; (d) contacting compound (4) with CO in the presence of 1,8-diazabicyclo[5.4.0]undec-7-ene (DBU), thereby forming a compound of formula (5): a step of synthesizing the compound of TIFF2026016384000038.tif23170; (e) contacting the compound of formula (5) with POCl3 and DIPEA, followed by contacting with tert-butyl (S)-3-methylpiperazine-1-carboxylate, thereby obtaining the compound of formula (5b) synthesizing the compound of TIFF2026016384000039.tif38170; and (f) contacting the compound of (5b) with KF, 1,4-diazabicyclo[2.2.2]octane (DABCO) and MsOH, thereby forming the compound of formula (2).

[0112] In one embodiment, step (a) of process (P5) is carried out in DMF as solvent.

[0113] In another embodiment, method (P1) comprises the step of preparing a compound of formula (G) by method (P7): TIFF2026016384000040.tif52170(in formula:X A teeth, TIFF2026016384000041.tif233170), or a tautomer, solvate, or pharmaceutically acceptable salt thereof; This method is (a) reacting a compound of formula (I) synthesized as described herein, or a solvate, tautomer, stereoisomer, atropisomer, or salt thereof, with X in the presence of a base and an activating agent. A with a moiety comprising: TIFF2026016384000042.tif53170(b) A compound of formula (G1) from which a PG group and optionally R 1 and removing; and (c) reacting the compound of step (b) with R 5 is unsubstituted C 1-6 Formula (VII) which is alkyl or phenyl TIFF2026016384000043.tif17170, followed by contacting with a base, thereby producing a compound of Formula (G), or a tautomer, stereoisomer, atropisomer, or pharmaceutically acceptable salt thereof. 5 is phenyl. In one embodiment, R 5 is methyl, ethyl, propyl or t-butyl.

[0114] In one embodiment, the compound of formula (VII) has the formula It has TIFF2026016384000044.tif18170(7).

[0115] In one embodiment, X A teeth, The file is TIFF2026016384000045.tif131170.

[0116] In one embodiment, X A teeth, The file is TIFF2026016384000046.tif97170.

[0117] In one embodiment, X A teeth TIFF2026016384000047.tif14170. In one such embodiment, X A teeth The file is TIFF2026016384000048.tif13170.

[0118] Formula (1): TIFF2026016384000049.tif52170, or a pharmaceutically acceptable salt thereof (P8), the method comprising: (a) Formula (2) A pre-cooled solution containing the compound of formula (2a) or a salt thereof is contacted with a pre-cooled solution containing i-PrMgCl·LiCl using a flow rate that provides a residence time of about 15-150 seconds for Mg-Br exchange, thereby forming a compound of formula (2a); A step of synthesizing the compound of TIFF2026016384000051.tif43170(2a); (b) transferring the compound of formula (2a) from step (a) to a continuous stirred tank reactor (CSTR) containing a pre-cooled solution of ZnCl or Zn(OPiv) and maintaining a constant residence time of about 3 to 7 minutes at about -20°C to 20°C to obtain the compound of formula (2b); a step of synthesizing the compound of TIFF2026016384000052.tif42170(2b); (c) Reacting the compound of formula (2b) with NaTFA and a compound of formula (3) contacting the compound of claim 1 with a compound of claim 1; (d) contacting the mixture of step (c) or a salt thereof with a Pd or Ni catalyst precursor and a chiral ligand, thereby forming a compound of formula (11): synthesizing a compound of TIFF2026016384000054.tif48170, or a solvate or salt thereof; (e) reacting a compound of formula (11) or a solvate or salt thereof with a compound of formula HO-X A (In the formula, X A is an expression TIFF2026016384000055.tif13170) and a base, thereby forming a compound of formula (1b); TIFF2026016384000056.tif43170, or a solvate or pharmaceutically acceptable salt thereof; (f) contacting a compound of formula (1b) with MsOH in an acid, thereby producing a compound of formula (1a); TIFF2026016384000057.tif39170, or a solvate or pharmaceutically acceptable salt thereof; and (g) reacting a compound of formula (1a) or a solvate or a pharmaceutically acceptable salt thereof in the presence of an activating agent, TIFF2026016384000058.tif18170, followed by contacting with a base, thereby producing a compound of formula (1), or a pharmaceutically acceptable salt thereof. Further provided herein is a method (P8) comprising:

[0119] In one embodiment, the residence time for step (a) of method (P8) is about 15 to 45 seconds, 15 to 60 seconds, 15 to 90 seconds, 15 to 100 seconds, or 15 to 120 seconds. In one embodiment, the residence time for step (a) of method (P8) is about 30 to 45 seconds, 30 to 60 seconds, 30 to 90 seconds, 30 to 120 seconds, or 30 to 150 seconds. In yet another embodiment, the residence time for step (a) of method (P8) is about 15 to 45 seconds or 60 to 90 seconds. In one embodiment, the residence time for step (a) of method (P8) is about 15 to 45 seconds. In one embodiment, the residence time for step (a) of method (P8) is about 60 to 90 seconds. In one embodiment, the residence time for step (a) of method (P8) is about 60 to 150 seconds. In one embodiment, the residence time in step (a) of method (P8) is about 90 to 150 seconds.

[0120] In one embodiment of the method of (P8), the pre-cooled solution of ZnCl or Zn(OPiv) further comprises LiCl. In one such embodiment, the pre-cooled solution comprises Zn(OPiv)·LiCl.

[0121] In one embodiment of method (P8), compound 2b is as described herein. In one such embodiment, p is 1, m is 1, and X 2 is a halogen (e.g., Cl or Br). In another such embodiment, compound 2b has X 2 In one embodiment, compound 2b contains at least two or three different species. In one such embodiment, the number of species depends on the number of equivalents of zinc compound used. In one such embodiment, more equivalents of zinc compound compared to compound 2a results in more species. In one embodiment, the species can be interconverted without affecting the kinetics of the subsequent reaction. In one embodiment, the species is X as Br only when m is 1. 2 Includes.

[0122] In one embodiment, the compound of formula (2) is prepared according to method (P5) as described herein. In one embodiment, the compound of formula (3) is prepared according to method (P6).

[0123] Formula (1): TIFF2026016384000059.tif52170, or a pharmaceutically acceptable salt thereof (P8), the method comprising: (a) Formula (2) contacting a pre-cooled solution containing the compound of formula TIFF2026016384000060.tif40170, or a salt thereof, with a pre-cooled solution containing i-PrMgCl·LiCl using a flow rate that provides a residence time for Mg-Br exchange of about 15 to 150 seconds; (b) transferring the mixture of step (a) to a continuous stirred tank reactor (CSTR) containing a pre-cooled solution of ZnCl or Zn(OPiv) and maintaining a constant residence time of about 3 to 7 minutes at about -20°C to 20°C; (c) adding the mixture of step (b) to NaTFA and a compound of formula (3) contacting the compound of claim 1 with a compound of claim 1; (d) contacting the mixture of step (c) or a salt thereof with a Pd or Ni catalyst precursor and a chiral ligand, thereby forming a compound of formula (11): synthesizing a compound of TIFF2026016384000062.tif48170, or a solvate or salt thereof; (e) reacting a compound of formula (11) or a solvate or salt thereof with a compound of formula HO-X A (In the formula, X A is an expression TIFF2026016384000063.tif13170) and a base, thereby forming a compound of formula (1b); TIFF2026016384000064.tif43170, or a solvate or pharmaceutically acceptable salt thereof; (f) contacting a compound of formula (1b) with MsOH in an acid, thereby producing a compound of formula (1a); TIFF2026016384000065.tif39170, or a solvate or pharmaceutically acceptable salt thereof; and (g) reacting a compound of formula (1a) or a solvate or a pharmaceutically acceptable salt thereof in the presence of an activating agent, Further provided herein is a method (P9) comprising contacting a compound of formula (1) with TIFF2026016384000066.tif18170, followed by contacting with a base, thereby producing a compound of formula (1), or a pharmaceutically acceptable salt thereof.

[0124] In one embodiment, the residence time for step (a) of method (P9) is about 15 to 45 seconds, 15 to 60 seconds, 15 to 90 seconds, 15 to 100 seconds, or 15 to 120 seconds. In one embodiment, the residence time for step (a) of method (P9) is about 30 to 45 seconds, 30 to 60 seconds, 30 to 90 seconds, 30 to 120 seconds, or 30 to 150 seconds. In yet another embodiment, the residence time for step (a) of method (P9) is about 15 to 45 seconds or 60 to 90 seconds. In one embodiment, the residence time for step (a) of method (P9) is about 15 to 45 seconds. In one embodiment, the residence time for step (a) of method (P9) is about 60 to 90 seconds. In one embodiment, the residence time for step (a) of method (P9) is about 60 to 150 seconds. In one embodiment, the residence time in step (a) of method (P9) is about 90 to 150 seconds.

[0125] In one embodiment of method (P9), the pre-cooled solution of ZnCl or Zn(OPiv) further comprises LiCl. In one such embodiment, the pre-cooled solution comprises Zn(OPiv)·LiCl. In one such embodiment, the pre-cooled solution comprises Zn(OPiv)·LiCl, and the residence time in step (a) of method (P9) is about 60-90 seconds or about 60-150 seconds.

[0126] In one embodiment, the compound of formula (2) is prepared according to method (P5) as described herein. In one embodiment, the compound of formula (3) is prepared according to method (P6).

[0127] As used herein, "continuous flow" refers to chemical reactions conducted in a continuous flow rather than batch production. In such cases, pumps move fluids through a flow system where they come into contact with each other and a reaction occurs. In some embodiments, a microreactor is used. In some embodiments, a tubular or plug flow reactor (PFR) is used. In other embodiments, a continuous stirred tank reactor (CSTR) is used. In such embodiments, the reactor may be cooled prior to the transfer of reagents or reactants therein. The continuous flow reactions described herein eliminate the need for low temperatures (e.g., -78°C) typically used for such reactions. Eliminating the need for such low temperatures increases reaction efficiency and allows for more robust scale-up to commercial-scale product quantities. Furthermore, the continuous flow reactions described herein improve the process's robustness and controllability of reaction conditions. The methods described herein result in better purity of the synthesized intermediates and compounds and reduce the time required for the reaction and production of compound (1).

[0128] Methods for treating cancer Compound 1, or a pharmaceutically acceptable salt thereof, inhibits KRas G12C It can be administered to patients in an effective amount (for example, the amount described herein) to treat mutation-mediated cancer.In one such embodiment, the cancer is a solid tumor (for example, lung cancer, CRC, or pancreatic cancer).It should be understood that the methods described herein also include treatment with a pharmaceutical composition as described herein, comprising compound 1 as described herein or a pharmaceutically acceptable salt thereof.

[0129] In one embodiment, KRas G12C A method of treating mutation-mediated lung cancer in a patient having such cancer, comprising administering to the patient having the cancer an effective amount of Compound 1 or a pharmaceutically acceptable salt thereof.

[0130] In such embodiments, the lung cancer is KRas G12CThe lung cancer is a non-small cell lung cancer (NSCLC) containing a mutation. In another embodiment, the lung cancer is an adenocarcinoma, a squamous cell lung cancer, or a large cell lung cancer. In one such embodiment, the cancer is a lung adenocarcinoma. In another such embodiment, the lung cancer is a small cell lung cancer. In another embodiment, the lung cancer is a small cell lung carcinoma. In yet another embodiment, the lung cancer is an adenocarcinoma, a carcinoid tumor, or an undifferentiated carcinoma. The lung cancer can be stage I or stage II lung cancer. In one embodiment, the lung cancer is stage III or stage IV lung cancer.

[0131] Further provided herein is the use of Compound 1, or a pharmaceutically acceptable salt thereof (UL1), for the treatment of lung cancer as described herein.

[0132] KRas G12C Also provided herein is a method of treating mutation-mediated colorectal cancer in a patient having such cancer, comprising administering to the patient having cancer an effective amount of Compound 1, or a pharmaceutically acceptable salt thereof.

[0133] Further provided herein is the use of Compound 1, as described herein, or a pharmaceutically acceptable salt thereof (UC1), for treating colorectal cancer as described herein.

[0134] KRas G12C Further provided herein is a method of treating mutation-mediated pancreatic cancer in a patient having such cancer, comprising administering to the patient having the cancer an effective amount of Compound 1, as described herein, or a pharmaceutically acceptable salt thereof.

[0135] Further provided herein is the use of Compound 1, or a pharmaceutically acceptable salt thereof, as described herein (UP1), for the treatment of pancreatic cancer as described herein.

[0136] KRas G12CFurther provided herein are methods of treating tumor-independent cancers comprising a mutation in a patient having such cancer. In one such embodiment, the method comprises treating a tumor-independent cancer comprising a mutation in KRas G12C 1. A method of treating a tumor-independent cancer comprising: (a) KRas in samples taken from patients diagnosed with suspected cancer G12C Determining the absence or presence of a mutation; and (b) treating tumor-independent cancer in a patient having such cancer by administering to the patient an effective amount of Compound 1 as described herein or a pharmaceutically acceptable salt thereof.

[0137] Further provided herein is the use of Compound 1, or a pharmaceutically acceptable salt thereof (UA1), as described herein, for treating a tumor-independent cancer as described herein.

[0138] In one embodiment of the methods and uses described herein, Compound 1 or a pharmaceutically acceptable salt thereof is administered as a fixed dose QD. In one embodiment, administration is oral (PO) and Compound 1 or a pharmaceutically acceptable salt thereof is formulated as a tablet or capsule. In one embodiment, Compound 1 or a pharmaceutically acceptable salt thereof is administered in an amount of 5 mg to 600 mg, 5 mg to 500 mg, 5 mg to 400 mg, 5 mg to 300 mg, 5 mg to 250 mg, 5 mg to 200 mg, 5 mg to 150 mg, 5 mg to 100 mg, 5 mg to 50 mg, 5 mg to 25 mg, 25 mg to 600 mg, 25 mg to 500 mg, 25 mg to 4 ... In another embodiment, Compound 1 or a pharmaceutically acceptable salt thereof is administered QD in an amount of about 5 mg, 25 mg, 50 mg, 100 mg, 150 mg, 200 mg, 25 mg, 300 mg, 400 mg, or 500 mg.

[0139] Embodiments: Some exemplary embodiments of the present invention are provided below.

[0140] Embodiment 1. Formula (I); TIFF2026016384000067.tif52170(in the formula, 1 and X 3 are each independently hydrogen or halogen; R 1 is hydrogen or PG 1 and; Each R 2 are independently selected from halogen, cyano, and unsubstituted C 1-6 Alkyl, unsubstituted C 1-6 Cyanoalkyl, or unsubstituted C 1-6 is haloalkyl; R 3 is hydrogen, halogen, R 3A -substituted or unsubstituted C 1-3 Alkyl, R 3A -substituted or unsubstituted C 1-3 Haloalkyl, or R 3A -substituted or unsubstituted cyclopropyl; R 3A is halogen, OH, CN, unsubstituted C 1-3 Alkyl or unsubstituted C 1-3 is haloalkyl; R 4 is R 4A -substituted or unsubstituted C 1-3 is haloalkyl; R 4A is the unsubstituted C 1-3 is alkyl; n is 1 or 2; each PG is independently an amino protecting group; PG 1 is an amino protecting group), or a solvate, tautomer, stereoisomer, atropisomer or salt thereof, comprising: This method is (a) Formula (II) TIFF2026016384000068.tif43170(in the formula, 2 is a halogen) with an organomagnesium compound, thereby forming a compound of formula (IIa): forming a compound of formula TIFF2026016384000069.tif47170 (IIa); (b) transferring the compound of formula (IIa) from step (a) to a continuous stirred tank reactor (CSTR) containing a zinc compound, thereby producing a compound of formula (IIb): TIFF2026016384000070.tif45170 (wherein m is 0, 1, or 2; p is 1, 2 or 3; X 2 is a halogen or OPiv; (c) reacting compound (IIb) of step (b) with a compound of formula (III) TIFF2026016384000071.tif26170(in the formula, 4 is a halogen), 1. A method for synthesizing a compound of formula (I), or a solvate, tautomer, stereoisomer, atropisomer, or salt thereof, comprising the step of contacting a transition metal catalyst precursor with a chiral ligand, thereby synthesizing the compound of formula (I).

[0141] Embodiment 2.X 2 2. The method of embodiment 1, wherein is Br, Cl or OPiv.

[0142] Embodiment 3. A compound of formula (II): (a) In the presence of a base, CO2 reacts with a compound of formula (IV) Compound (V) of TIFF2026016384000072.tif22170 cyclization to compound TIFF2026016384000073.tif24170; (b) contacting the compound of formula (V) with a chlorinating agent, thereby forming a compound of formula (Va) To synthesize the compound TIFF2026016384000074.tif24170; (c) reacting the compound of step (b) with a compound of formula (I) in the presence of a base; TIFF2026016384000075.tif24170, thereby contacting a piperazinyl moiety having formula (Vb) synthesizing the compound TIFF2026016384000076.tif42170; and (d) contacting the compound of step (c) with a fluorinating agent in the presence of a base, thereby synthesizing a compound of formula (II). 3. The method of claim 1 or 2, wherein the compound is prepared by a method (P2) comprising:

[0143] Embodiment 4. The method of embodiment 3, wherein the base in step (a) is DBU.

[0144] Embodiment 5. The method of embodiment 3, wherein the chlorinating agent in step (b) is POCl3.

[0145] Embodiment 6. The method of embodiment 3, wherein the base in step (c) is DIPEA.

[0146] Embodiment 7. The method of embodiment 3, wherein the fluorinating agent in step (d) is KF.

[0147] Embodiment 8. A compound of formula (IV) is: (a) Formula (IVa) TIFF2026016384000077.tif23170 is contacted with i-PrMgCl, thereby forming a compound of formula (IVb) To synthesize the compound TIFF2026016384000078.tif19170; (b) contacting the compound of step (a) with hydroxylamine, thereby forming a compound of formula (IVc) To synthesize the compound TIFF2026016384000079.tif27170; (c) contacting the compound of step (b) with a base and a dehydrating agent in acetonitrile, thereby obtaining a compound of formula (IVd) To synthesize the compound TIFF2026016384000080.tif19170; (d) contacting the compound of step (c) with ammonia, thereby forming a compound of formula (IVe): synthesizing the compound TIFF2026016384000081.tif19170; and (e) contacting the compound of step (d) with a chlorinating agent, thereby synthesizing a compound of formula (IV). 8. The method of any one of embodiments 3 to 7, wherein the compound is prepared by a method (P3) comprising:

[0148] Embodiment 9. A compound of formula (III) is: (a) (where X 6 is Cl or I) TIFF2026016384000082.tif22170 with a halogenating agent to form a compound of formula (VIb) To form compounds of TIFF2026016384000083.tif22170; (b) brominating a compound of formula (VIb) to form a compound of formula (VI) forming a compound of TIFF2026016384000084.tif22170; and (c) contacting the compound of formula (VI) with a compound having the formula NH(PG)2, thereby producing a compound of formula (III). 2. The method of embodiment 1, wherein the compound is prepared by a method (P4) comprising:

[0149] Embodiment 10.X 6 10. The method of embodiment 9, wherein is Cl.

[0150] Embodiment 11. The method of embodiment 9, wherein the halogenating agent is SF4 in HF.

[0151] Embodiment 12. The method of embodiment 9, wherein the bromination is carried out using HBr in acid.

[0152] Embodiment 13. A compound of formula (III) is: The method of any one of embodiments 9 to 12, having TIFF2026016384000085.tif24170.

[0153] Embodiment 14.X 1 14. The method of any one of embodiments 1 to 13, wherein is a halogen.

[0154] Embodiment 15.X 1 14. The method of any one of embodiments 1-13, wherein is F or Cl.

[0155] Embodiment 16.X 3 14. The method of any one of embodiments 1 to 13, wherein is a halogen.

[0156] Embodiment 17.X 3 14. The method of any one of embodiments 1-13, wherein is F or Cl.

[0157] Embodiment 18.R 1 is PG 1 18. The method of any one of embodiments 1 to 17, wherein

[0158] Embodiment 19.PG 1 19. The method of any one of embodiments 1-18, wherein is Ac (acetyl), trifluoroacetyl, Bn (benzyl), Tr (triphenylmethyl or trityl), benzylidenyl, p-toluenesulfonyl, PMB (p-methoxybenzyl), Boc (tert-butyloxycarbonyl), Fmoc (9-fluorenylmethyloxycarbonyl), or Cbz (carbobenzyloxy).

[0159] Embodiment 20.R 1 20. The method of any one of embodiments 1-19, wherein is Boc (tert-butyloxycarbonyl).

[0160] Embodiment 21.R 2 is unsubstituted C 1-6 Alkyl or unsubstituted C 1-6 21. The method of any one of embodiments 1 to 20, wherein the alkyl is cyanoalkyl.

[0161] Embodiment 22.R2 22. The method of any one of embodiments 1-21, wherein is methyl.

[0162] Embodiment 23.R 3 is hydrogen or R 3A -substituted or unsubstituted C 1-3 23. The method of any one of embodiments 1 to 22, wherein the alkyl is alkyl.

[0163] Embodiment 24.R 3 24. The method of any one of embodiments 1-23, wherein is methyl.

[0164] Embodiment 25.R 4 25. The method of any one of embodiments 1-24, wherein is CF3, CHF2, or CH2F.

[0165] Embodiment 26.R 3 is methyl and R 4 26. The method of any one of embodiments 1-25, wherein is CF3.

[0166] Embodiment 27. The method of any one of embodiments 1 to 26, wherein each PG is independently a protecting group selected from the group consisting of Ac (acetyl), trifluoroacetyl, phthalimide, Bn (benzyl), Tr (triphenylmethyl or trityl), benzylidenyl, p-toluenesulfonyl, DMB (dimethoxybenzyl), PMB (p-methoxybenzyl), Boc (tert-butyloxycarbonyl), Fmoc (9-fluorenylmethyloxycarbonyl), or Cbz (carbobenzyloxy).

[0167] Embodiment 28. The method of embodiment 27, wherein each PG is p-methoxybenzyl.

[0168] Embodiment 29. The method of any one of embodiments 1 to 28, wherein the organomagnesium compound is selected from the group consisting of isopropyl magnesium chloride, isopropyl magnesium bromide, isopropyl magnesium iodide, isopropyl magnesium chloride lithium chloride complex, sec-butyl magnesium chloride, lithium tri-n-butyl magnesiate, lithium triisopropyl magnesiate, and lithium (isopropyl)(di-n-butyl)magnesiate.

[0169] Embodiment 30. The method of embodiment 29, wherein the organomagnesium compound is i-PrMgCl·LiCl.

[0170] Embodiment 31. The method of any one of embodiments 1 to 30, wherein the zinc compound is selected from the group consisting of ZnCl2, ZnBr2, ZnI2, Zn(TFA)2, Zn(OAc)2, and Zn(OPiv)2.

[0171] Embodiment 32. The method of embodiment 31, wherein the zinc compound is Zn(OPiv)2·LiCl.

[0172] Embodiment 33. The transition metal catalyst precursor is a Pd or Ni catalyst precursor, and is selected from the group consisting of Pd(OAc)2, PdCl2, PdCl2(MeCN)2, and Pd(benzonitrile)2Cl. 2、 32. The method of any one of embodiments 1-31, wherein the compound is selected from the group consisting of Pd(dba)2, Pd2(dba)3, Pd(PPh3)4, Pd(PCy3)2, Pd(PtBu3)2, Pd(TFA)2, [Pd(allyl)Cl]2, [Pd(cinnamyl)Cl]2, [PdCl(crotyl)]2, PdCl(η5-cyclopentadienyl), [(η3-allyl)(η5-cyclopentadienyl)palladium(II)], [Ni(η5-cyclopentadienyl)(allyl)], [bis(1,5-cyclooctadiene)nickel(0)], NiCl2, NiBr2, Ni(OAc)2, and nickel(II) acetylacetonate.

[0173] Embodiment 34. The chiral ligand is TIFF2026016384000086.tif46170(in the formula, Y is O or NR 7 and; R 7 and R 8 are independently unsubstituted C 1-6 33. The method of any one of embodiments 1-32, wherein R is alkyl.

[0174] Embodiment 35.R 7 and R 8 34. The method of embodiment 33, wherein

[0175] Embodiment 36.R 7 and R 8 is each independently methyl, ethyl, or phenyl.

[0176] Embodiment 37. The method of any one of embodiments 1 to 33, wherein the chiral ligand is an (R,R)-chiraphite ligand.

[0177] Embodiment 38. The method of any one of embodiments 1 to 34, wherein the zinc compound is Zn(OPiv)2·LiCl, the Pd catalyst precursor is [Pd(cinnamyl)Cl]2, and the chiral ligand is an (R,R)-chiraphite ligand.

[0178] Embodiment 39. The compound of formula (I) has the formula: 2. The method of embodiment 1, having TIFF2026016384000087.tif100170.

[0179] Embodiment 40. The compound of formula (I) has the formula: TIFF2026016384000088.tif48170(in the formula, 3 10. The method of claim 1, wherein

[0180] Embodiment 41. The compound of formula (I) has the formula: 2. The method of embodiment 1, having TIFF2026016384000089.tif46170(11).

[0181] Embodiment 42. Formula (2) TIFF2026016384000090.tif38170(2) A method (P5) for synthesizing a compound of the formula: This method is (a) Equation (4a) The compound of formula (4c) is contacted with i-PrMgCl and subsequently with hydroxylamine, thereby forming a compound of formula (4c) a step of synthesizing the compound of TIFF2026016384000092.tif27170; (b) contacting a compound of formula (4c) with TFAA and triethylamine in acetonitrile, followed by contact with ammonia, thereby producing a compound of formula (4e): a step of synthesizing the compound of TIFF2026016384000093.tif19170; (c) contacting the compound of (4e) with a chlorinating agent, thereby forming a compound of formula (4) a step of synthesizing the compound of TIFF2026016384000094.tif19170; (d) contacting compound (4) with CO2 in the presence of DBU, thereby forming a compound of formula (5): a step of synthesizing the compound of TIFF2026016384000095.tif23170; (e) contacting a compound of formula (5) with POCl3 and DIPEA, followed by contacting with tert-butyl (S)-3-methylpiperazine-1-carboxylate in DIPEA, thereby forming a compound of formula (5b): synthesizing the compound of TIFF2026016384000096.tif38170; and (f) A method (P5) comprising contacting a compound of (5b) with KF, DABCO and MsOH, thereby forming a compound of formula (2).

[0182] Embodiment 43. The compound of formula (III) has the formula: TIFF2026016384000097.tif19170(3); The compound of formula (3) (a) Equation (6a) TIFF2026016384000098.tif19170 is contacted with SF4 and HF, thereby forming a compound of formula (6b) To synthesize the compound TIFF2026016384000099.tif19170; (b) contacting a compound of formula (6b) with HBr in AcOH to form a compound of formula (6): To form compounds of TIFF2026016384000100.tif19170; (c) contacting the compound of formula (6) with (PMB)2NH, triethylamine and NBP, thereby synthesizing the compound of formula (III). 2. The method of embodiment 1, wherein the compound is synthesized by method (P6), comprising:

[0183] Embodiment 44. A compound represented by formula (G) by method (P7) TIFF2026016384000101.tif52170(in formula:X A teeth, TIFF2026016384000102.tif234170), or a tautomer, stereoisomer, atropisomer, or pharmaceutically acceptable salt thereof, wherein: This method is (a) reacting a compound of formula (I), or a solvate, tautomer, stereoisomer, atropisomer, or salt thereof, with X in the presence of a base and an activating agent; A with a moiety comprising: TIFF2026016384000103.tif53170(b) A compound of formula (G1) from which a PG group and optionally R 1 and removing; and (c) reacting the compound of step (b) with the compound of formula (VII) in the presence of an activating agent TIFF2026016384000104.tif17170, followed by contacting with a base, thereby producing a compound of formula (G), or a tautomer, stereoisomer, atropisomer, or pharmaceutically acceptable salt thereof. A method comprising:

[0184] Embodiment 45. Formula: (1) TIFF2026016384000105.tif52170, or a pharmaceutically acceptable salt thereof (P8), the method comprising: (a) Formula (2) contacting a pre-cooled solution containing the compound of formula TIFF2026016384000106.tif40170, or a salt thereof, with a pre-cooled solution containing i-PrMgCl·LiCl using a flow rate that provides a residence time for Mg-Br exchange of about 15 to 150 seconds; (b) transferring the mixture of step (a) to a continuous stirred tank reactor (CSTR) containing a pre-cooled solution of ZnCl or Zn(OPiv) and maintaining a constant residence time of about 3 to 7 minutes at about -20°C to 20°C; (c) adding the mixture of step (b) to NaTFA and a compound of formula (3) contacting the compound of claim 1 with a compound of claim 1; (d) contacting the mixture of step (c) or a salt thereof with a Pd or Ni catalyst precursor and a chiral ligand, thereby forming a compound of formula (11): synthesizing a compound of TIFF2026016384000108.tif48170, or a solvate or salt thereof; (e) reacting a compound of formula (11) or a solvate or salt thereof with a compound of formula HO-X A (In the formula, X A is an expression TIFF2026016384000109.tif13170) and a base, thereby forming a compound of formula (1b); synthesizing a compound of formula TIFF2026016384000110.tif43170, or a solvate or pharmaceutically acceptable salt thereof; (f) contacting a compound of formula (1b) with MsOH in an acid, thereby producing a compound of formula (1a); TIFF2026016384000111.tif39170, or a solvate or pharmaceutically acceptable salt thereof; and (g) reacting a compound of formula (1a) or a solvate or a pharmaceutically acceptable salt thereof in the presence of an activating agent, TIFF2026016384000112.tif18170, followed by contacting with a base, thereby producing a compound of formula (1), or a pharmaceutically acceptable salt thereof (P9).

[0185] Embodiment 46. The method of embodiment 45, wherein the acid in step (f) is AcOH, trifluoroacetic acid, chlorosulfonic acid, sulfuric acid, HCl, HBr, p-toluenesulfonic acid, or trifluoromethanesulfonic acid.

[0186] Embodiment 47. The method of embodiment 45, wherein compound (2) is synthesized according to the method of embodiment 42.

[0187] Embodiment 48. The method of embodiment 45, wherein the pre-cooled solution of step (b) comprises Zn(OPiv)2·LiCl.

[0188] Working Example: The following examples are offered by way of illustration and not by way of limitation.

[0189] Example 1: Compound 2: tert-butyl (S)-4-(7-bromo-6-chloro-2,8-difluoroquinazolin-4-yl)-3-methylpiperazine-1-carboxylate TIFF2026016384000113.tif111170

[0190] Process 1

[0191] To a solution of 1,4-dibromo-2,3-difluorobenzene (100 g) in THF (200 mL) was added isopropylmagnesium bromide (1.1 equiv., 2 M in THF) over at least 2 h at 0 °C. After stirring for 30 min, DMF (2.0 equiv.) was added over at least 3 h. After aging for 1 h (IPC conversion >97.5% a / a), the mixture was added in one portion to a cooled solution (0 °C) of citric acid (1.2 equiv.) in water (1 Veq.). The mixture was warmed to 45 °C, and the aqueous phase was separated.

[0192] Process 2

[0193] To the organic phase containing 4b, hydroxylamine (1.05 equiv., 50% wt. in water) was added over at least 1 h at 45 °C. After stirring for 30 min (IPC conversion >98.8% a / a), brine (100 mL) was added at the same temperature. The aqueous phase was separated, and the organic phase was concentrated to a total volume of 200 mL by vacuum distillation. The vacuum distillation was then carried out under constant volume by feeding acetic acid (200 mL). After adjusting the solution to 70 °C, water (100 mL) was added over at least 30 min and seeded. The resulting suspension was cooled to 20 °C, followed by the addition of water (100 mL). The precipitate was filtered, the filter cake was washed with ACN / water (1:2), and the wet product was dried under reduced pressure to give 77.6 g of 4c (89% o.th.). 1 H NMR(400 MHz,DMSO-d6)δ [ppm]=11.89(s,1H),8.19(s,1H),7.56-7.46(m,2H).

[0194] Steps 3 and 4

[0195] To a suspension of 4c (100 g) in ACN (200 mL) was added triethylamine (2.2 equiv.) at 20 °C. To the resulting solution, TFAA (1.1 equiv.) was added over at least 2.5 h. After the addition was complete, the reaction mixture was stirred for 30 min (IPC conversion >99.8% a / a). The solution containing 4d was placed in an autoclave, and ammonia (6.8 equiv., 25% wt. in water) was added in one portion. The vessel was sealed and heated at 120 °C for at least 6 h (IPC conversion >99.0% a / a). The mixture was adjusted to 90 °C and then cooled to 50 °C over at least 3 h. Water (220 mL) was then added over at least 1 h. The suspension was then further cooled to 20 °C and aged for 1 h. The precipitate was filtered, and the filter cake was washed with ACN / water (1:2). The wet product was dried under vacuum to give 75.6 g of 4e (83% o.th.). 1 H NMR(400 MHz,DMSO-d6)δ [ppm]=7.23(br d,J=8.4 Hz,1H),6.86(dd,J=8.4,6.1 Hz,1H),6.49(bs,2H).

[0196] Step 5:

[0197] To a solution of 4e (100 g) in DMF (500 mL) was added HCl in dioxane (4.0 M, 0.25 equiv.) at 0 °C. The solution was cooled to -5 °C, and NCS (1.15 equiv.) was added portionwise while maintaining the temperature below 2 °C (target -5 °C). After the addition was complete, the reaction mixture was stirred at -5 °C for 1.5 h (IPC). n-PrOH (100 mL) was then added at 0 °C to initiate precipitation of the product (visual IPC for the suspension). After stirring for at least 30 min, water (250 mL) was added at 0-5 °C over at least 1.5 h. The suspension was filtered, and the filter cake was washed twice with ACN / water (1:2) (100 mL). The wet product was dried in a vacuum oven at 60 °C to give 102.8 g of 4 (89% o.th.). 1 H NMR(400 MHz,DMSO-d6)δ [ppm]=7.67(d,J=2.1 Hz,1H),6.49(bs,2H).

[0198] Alternative Step 5: TIFF2026016384000114.tif35170

[0199] To a solution of 4e (100 g) in DMF (700 mL) was added HCl in dioxane (4.0 M, 0.25 equiv.) at 40 °C. The solution was cooled to -5 °C, and 1,3-dichloro-5,5-dimethylhydantoin (DCH) (0.60 equiv.) was added portionwise. After the addition was complete, the reaction temperature was adjusted to -10 to 0 °C and stirred for an additional 1.5 h. n-PrOH (140 mL) and water (350 mL) were then added at -5 to 5 °C to initiate precipitation of the product (visual IPC of the suspension). After stirring for at least 30 min at -5 to 5 °C, the suspension was filtered, and the filter cake was washed twice with ACN / water (1:2) (2 × 100 mL). The wet product was dried in a vacuum oven at 60 °C to give 97.5 g of 4 (84% o.th.). 1 H NMR(400 MHz,DMSO-d6)δ [ppm]=7.67(d,J=2.1 Hz,1H),6.49(bs,2H).

[0200] Step 6:

[0201] A suspension of 4 (50 g) in DMSO (150 mL) was stirred at 25°C under a CO atmosphere for 15 min, after which DBU (33.6 g) was added. After stirring at 25°C for 1 h, the reaction was heated to 70°C and stirred for an additional 6 h (IPC: 4 < 1.0% a / a). Acetic acid (14.4 g) was then added over at least 1 h. The mixture was stirred at 70°C for at least 1 h, after which water (50 mL) was added over at least 2 h. The resulting suspension was aged at 70°C for 3 h, then cooled to 25°C over at least 3 h and stirred at that temperature for an additional 1 h. The suspension was filtered and washed with DMSO / water (3:1, 50 mL) and IPA / water (1:1, 50 mL). The filter cake was suspended in IPA / water (1:2, 200 mL), stirred for at least 30 min, filtered, washed with IPA / water (1:1, 20 mL), and dried in a vacuum oven at 60 °C to give 55.0 g of 5 (93.5% o.th.). 1 H NMR(400 MHz,DMSO-d6)δ [ppm]=11.64(s,1H),11.60(s,1H),7.84(d,J=1.8 Hz,1H).

[0202] Step 7:

[0203] To a suspension of 5 (50 g) in toluene (300 mL) was added POCl (130.6 g) at 25 °C. After stirring the mixture for 30 min, DIPEA (49.5 g) was added over at least 2 h. The reaction mixture was warmed to 35 °C and stirred for 30 min. To the resulting solution, water (0.77 g) was added in one portion. The reaction mixture was heated to 70 °C, stirred for at least 2 h, and then cooled to 25 °C (IPC: 5a > 97.0% a / a). The reaction mixture was added to water (400 mL) over at least 1 h at 25 °C. After the addition was complete, the biphasic mixture was stirred for at least 30 min and then filtered through Harborlite 800 (10.3 g). The filter cake was rinsed with toluene (25 mL), and the phases were separated. The organic phase was washed with brine (20% w / w in water, 100 mL) and reduced to 160 mL by vacuum distillation.

[0204] Step 8:

[0205] The solution from step 7 was then telescoped and cooled to 25°C, and (S)-1-Boc-3-methylpiperazine (34.1 g) was added in five portions over at least 1 hour. After stirring for 30 minutes, DIPEA (24.2 g) was added within 1 hour, and the resulting suspension was stirred for 30 minutes (IPC: 5a<0.4%-a / a). The mixture was heated to 40°C and stirred for 1 hour, after which heptane was added over at least 1 hour. After stirring at 40°C for an additional 1 hour, the suspension was cooled to 25°C over at least 1 hour and aged for at least 2 hours. The suspension was filtered and washed with heptane / toluene (2:1, 50 mL). The filter cake was suspended in IPA / water (2:1, 200 mL), stirred for at least 30 minutes, filtered, washed twice with IPA / water (2:1, 100 mL), and dried in a vacuum oven at 45°C to give 74.1 g of 5b (88% o.th.). 1 H NMR (400 MHz, chloroform-d) δ [ppm] = 7.69 (d, J = 2.0 Hz, 1H), 4.74-4.65 (m, 1H), 4.30-3.85 (m, 3H), 3.68-3.56 (m, 1H), 3.33-2.97 (m, 2H), 1.48 (s, 9H), 1.45 (d, J = 6.7 Hz, 3H).

[0206] Step 9:

[0207] To a stirred suspension of 5b (20 g) in DMSO (100 mL) was added potassium fluoride (3.1 g, 1.3 equiv.), DABCO (0.18 g, 0.04 equiv.), and methanesulfonic acid (0.11 mL, 0.04 equiv.) at room temperature. The mixture was heated to 65 °C and stirred for at least 3 h. After complete conversion (IPC: 5b < 0.1% a / a), the mixture was cooled to 50 °C and stirred at the same temperature for at least 1 h (product precipitation occurred). The suspension was then cooled to 20 °C over at least 3 h, after which 40 mL of ACN / water (1:2) was added over at least 1 h. After stirring for 30 min, the precipitate was filtered and washed with 20 mL of ACN / water (1:1). The filter cake was suspended in 60 mL of ACN / water (1:2), stirred for at least 30 min, filtered, washed with 20 mL of ACN / water (1:2), and dried in a vacuum oven at 60 °C to give 17.9 g of 2 (95% o.th.). 1 H NMR(400 MHz,chloroform-d)δ [ppm]=7.76(d,J=1.9 Hz,1H),4.77-4.70(m,1H),4.28-4.22(m,1H),4.18-3.85(m,2H),3.66(dd,J=13.0,3.1 Hz,1H),3.34-3.00(m,2H),1.51(s,9H),1.49(d,J=6.9 Hz,3H).

[0208] Example 2: Continuous flow processing of compound (2b) TIFF2026016384000115.tif71170

[0209] Feed preparation

[0210] Feed 1: 273 g of 2 was dissolved in 1166 g of THF to give a 1500 mL solution (0.38 M) with a density of 0.96. Feed 2: i-PrMgCl·LiCl was used as a 1.20 M solution in THF (assay corrected for CoA). ZnCl2 was used as a 2.00 M (25.8 wt%) solution in 2-MeTHF (assay corrected for CoA).

[0211] The setup of the system described above is shown in Figure 1.

[0212] All pumps and transfer lines were purged with the corresponding feeds. Feed 1 containing compound 2 (1.00 equiv.) and Feed 2 containing i-PrMgCl⋅LiCl (1.05 equiv.) were pre-cooled and continuously charged into a suitable flow reactor at a jacket temperature (JT) of -20 to 0 °C. The flow rates of the two feeds were adjusted to provide a residence time of approximately 30 s for the Mg-Br exchange.

[0213] The effluent reaction mixture (compound 2a) was introduced into a continuous stirred tank reactor (CSTR), and a solution of ZnCl was added (1.15 equiv.) simultaneously, maintaining a constant residence time of approximately 5 min. The temperature was kept constant at an internal temperature (IT) of -10 °C.

[0214] Compound 2b was collected in a receiving tank at an IT of 0–25° C. Compound 2b was found to be stable at −20–25° C. for several weeks.

[0215] Example 2a: TIFF2026016384000116.tif64170

[0216] Feed preparation

[0217] Feed 1: 117 g of 2 was dissolved in 783 g of THF to give 959.5 mL of a 0.25 M solution with a density of 0.94. Feed 2: i-PrMgCl·LiCl was used as a 1.20 M solution in THF (assay corrected for CoA). Zn(OPiv)2·LiCl was used as a 0.67 M (20.0 wt%) solution in 2-MeTHF (assay corrected for CoA).

[0218] The setup of the system described above is shown in Figure 1.

[0219] All pumps and transfer lines were purged with the corresponding feeds. Feed 1, containing compound 2 (1.00 equiv.), and Feed 2, containing i-PrMgCl⋅LiCl (1.15 equiv.), were pre-cooled and continuously charged into a suitable flow reactor at a jacket temperature (JT) of -20 to 0 °C. The flow rates of the two feeds were adjusted to provide a residence time of approximately 45 s for the Mg-Br exchange.

[0220] The outflowing reaction mixture (compound 2a) was introduced into a continuous stirred tank reactor (CSTR), and a solution of Zn(OPiv) LiCl (0.75 equiv.) was added simultaneously while maintaining a constant residence time of approximately 5 min. The internal temperature (IT) was kept constant between -5 and 5 °C.

[0221] Compound 2b was collected in a receiving tank at an IT of 0-30° C. Compound 2b was found to be stable at −20-30° C. for several weeks.

[0222] Five different experiments were carried out, varying the equivalents of ZnCl2 and compound 2a from 0.33, 0.50, 0.75, and 1.00 to 1.50. 19 F NMR showed the presence of three different species / compounds at different levels depending on the equivalent amount of ZnCl used. 2D NOESY showed that these species could be interconverted without significantly affecting the kinetics of the resulting ZnCl.

[0223] Des-bromo-compound 2a is found as a separate compound present in the spectrum and originates from a proton quenching reaction due to residual moisture in the NMR solvent.

[0224] Example 3: TIFF2026016384000117.tif72170

[0225] Compound 2b was added in a suspension (32 mmol, 1.1 equiv.) to a first reactor under an argon atmosphere with a jacket temperature (TJ) of 10 °C. NaTFA (11.8 g, 86.8 mmol, 3.00 equiv.) was added in three portions over 30 min. The resulting suspension was heated (1 °C / min.) to an internal temperature (IT) of 50 °C over 40 min. In a second reactor under an argon atmosphere, compound 3 (14.4 g, 29.0 mmol, 1.00 equiv.) was added, and the reactor was purged with argon for 10 min. Degassed THF (26 mL) was added, and after stirring for 10 min, a solution was obtained. The solution was transferred to the first reactor via a pump over 5 min. Then, a solution of palladium (π-cinnamyl) chloride dimer (75.1 mg, 0.005 equiv.) and (R,R)-chiraphite (279.8 mg, 0.011 equiv.) in THF (8.0 mL) was transferred to the first reactor via syringe. The resulting solution was stirred at 50° C. IT until complete conversion was achieved (typically 15 h). The reaction mixture was cooled to room temperature (rt).

[0226] A tribasic aqueous solution of sodium citrate (20% w / w, 110 g) and toluene (72 mL) were added to a third reactor under an argon atmosphere at a temperature of 20°C. The reaction mixture in the second reactor was then transferred to the third reactor over 10 minutes. The biphasic mixture was stirred for 15 minutes, and then the lower aqueous layer was discharged from the third reactor. A tribasic aqueous solution of sodium citrate (20% w / w, 110 g) was then added to the third reactor. The biphasic mixture was stirred for 15 minutes, and then the lower aqueous layer was discharged from the third reactor. Aqueous sodium chloride solution (10% w / w, 36.5 g) was then added to the third reactor. The biphasic mixture was stirred for 15 minutes, and then the lower aqueous layer was discharged from the third reactor. The organic layer was concentrated under reduced pressure at a temperature of 50°C to a volume of approximately 140 mL. The toluene layer was then distilled under reduced pressure to a constant volume (typically replacing 64 g of toluene). The resulting solution was pumped over a heated charcoal filter over 45-60 minutes into a fourth reactor under an argon atmosphere. The third reactor and filter were rinsed with toluene (50 mL) and added to the fourth reactor. The resulting solution was concentrated under reduced pressure at 50°C to a volume of approximately 75 mL.

[0227] The solution was cooled to IT 20°C, and n-heptane (14 mL) was added over 10 min to seed. The suspension was aged for 1 h, and n-heptane (160 mL) was added over 2 h. The suspension was further stirred overnight. The crystals were filtered off, washed with a toluene / n-heptane solution (1:1 v / v), and dried under reduced pressure for 1 h to give the crude product (24.0 g) as a solid. The crude product (24.0 g) was suspended in toluene (100 mL). The suspension was stirred at TJ 50°C until a solution was obtained. The solution was concentrated under reduced pressure to a volume of approximately 70 mL. The solution was cooled to IT 20°C, and n-heptane (9 mL) was added over 10 min to seed. The suspension was aged for 1 h, and n-heptane (94 mL) was added over 2 h. The suspension was further stirred overnight. The crystals were filtered off, washed with a toluene / n-heptane solution (1:1 v / v), and dried under reduced pressure to a constant weight. The title compound was isolated as crystals in a yield of 57% (15.2 g).

[0228] Example 3a: TIFF2026016384000118.tif67170

[0229] NaTFA (15.5 g, 114.3 mmol, 3.00 equiv.) was charged to a first reactor under an argon atmosphere with a jacket temperature (TJ) of 20 °C. A solution of compound 2b in THF and 2-Me-THF (41.9 mmol, 1.10 equiv., 230 g) was added. The resulting suspension was heated to an internal temperature (IT) of 50 °C over 40 min (1 °C / min). In a second reactor under an argon atmosphere, compound 3 (18.9 g, 38.1 mmol, 1.00 equiv.) was added, and the reactor was purged with argon for 10 min. Degassed THF (30.5 g) was added, and after stirring for 10 min, a solution was obtained. The solution was transferred to the first reactor via a pump over 5 min. THF (8.9 g) was used to rinse the lines. Then, a solution of palladium (π-cinnamyl) chloride dimer (148 mg, 0.0075 equiv.) and (R,R)-chiraphite (551, 0.0165 equiv.) in THF (11.6 g) was transferred via syringe to the first reactor. The resulting solution was stirred at 50°C until complete conversion was achieved (typically 10 h). The reaction mixture was cooled to room temperature (rt).

[0230] A tribasic aqueous solution of sodium citrate (20% w / w, 150 g) and toluene (82.4 g) were added to a third reactor under an argon atmosphere at a temperature of 20°C. The reaction mixture in the second reactor was then transferred to the third reactor over 10 minutes. The biphasic mixture was stirred for 15 minutes, and then the lower aqueous layer was discharged from the third reactor. Aqueous solutions of tribasic sodium citrate and sodium carbonate (20% and 5% w / w, respectively, 150 g) were then added to the third reactor. The biphasic mixture was stirred for 15 minutes, and then the lower aqueous layer was discharged from the third reactor. Aqueous sodium chloride solution (10% w / w, 50.1 g) was then added to the third reactor. The biphasic mixture was stirred for 15 minutes, and then the lower aqueous layer was discharged from the third reactor. The organic layer was concentrated under reduced pressure at a temperature of 50°C to a volume of approximately 140 mL. The toluene layer was then vacuum distilled at constant volume (typically replacing 120 g of toluene) until the desired solvent composition was obtained. The resulting solution was pumped over a heated charcoal filter into a fourth reactor under an argon atmosphere over 45-60 minutes. The third reactor and filter were rinsed with toluene (32.7 g) and added to the fourth reactor. The resulting solution was concentrated under reduced pressure at 50°C to a volume of approximately 140 mL.

[0231] The solution was cooled to 20°C and n-heptane (12.9 g) was added over 10 min to seed. The suspension was aged for 2 h, and n-heptane (81 g) was added over 2 h. The suspension was cooled to 0°C over 2 h and stirred overnight. The crystals were filtered off, washed with a toluene / n-heptane solution (1:1 v / v), and dried under reduced pressure to constant weight. The title compound was isolated as crystals in 81.4% yield (28.7 g, 88% assay).

[0232] Example 4: Compound 3: 2,6-dichloro-4-methyl-5-(trifluoromethyl)pyridine

[0233] Step 1: TIFF2026016384000119.tif22170

[0234] 2,6-Dichloro-4-methyl-pyridine-3-carboxylic acid (1.0 equiv., 22 kg) was charged to an autoclave at ambient temperature. The autoclave was cooled to -20 °C and charged with HF (1.37 rel. wt.), then further cooled to -78 °C and charged with SF (2.5 equiv.). The autoclave was sealed and the reaction mixture was allowed to warm to ambient temperature, then slowly heated to 70-80 °C and stirred at the same temperature.

[0235] After completion, the volatiles were removed by sparging with nitrogen through a scrubber, and then MTBE (5 rel. vol.) was added. The reaction mass was slowly added to ice-cold demineralized (DM) water (5 rel. vol.) and then basified (pH 8-9) by adding 25% aqueous potassium carbonate (approx. 8 rel. vol.) below 10°C. The reaction mass was filtered through a Celite pad, washed with MTBE (2.5 rel. vol.), and the layers were separated. The aqueous layer was extracted with MTBE (2.5 rel. vol.). The combined organic layers were washed with DM water (2 x 2.5 rel. vol.) and concentrated below 30°C. The organic layers were concentrated under reduced pressure below 30°C, then methanol (1.0 rel. vol.) was charged and again distilled to a thick slurry.

[0236] Methanol (4.0 rel vol) followed by activated carbon Norit CG1 (10% w / w) was added to the slurry at 20-30°C and stirred for 60 min at the same temperature. The reaction mass was filtered through a bed of celite and washed with methanol (1.5 rel vol).

[0237] The product was purified as follows: To a solution of the product in MeOH, DM water (1.3 rel. vol.) was added at 20-30°C for 60 min (approx. 4.5 ml / min), followed by stirring at the same temperature for 20 min. The pure product was seeded into the above solution and stirred at 20-30°C for 20 min. The solution was slowly cooled to -4 to 2°C over 4 h. 0.7 + 0.5 + 0.5 rel. vol. (i.e., a total of 1.7 rel. vol.) DM water was added at -4 to 2°C for 30 min (approx. 6 ml / min) (a sample of the aqueous supernatant was checked for solid precipitation after each addition of each lot), followed by stirring at the same temperature for 3 h. The resulting solid was filtered and washed with chilled DM water.

[0238] Step 2: 2,6-Dibromo-4-methyl-3-(trifluoromethyl)pyridine TIFF2026016384000120.tif36170

[0239] 2,6-Dichloro-4-methyl-5-(trifluoromethyl)pyridine (5.00 kg, 1.00×, 1.00 equiv.) and hydrobromic acid in acetic acid (21.0 kg) were added to a 3000 L-GL reactor. The reactor was adjusted to 110-120°C, and hydrobromic acid in acetic acid (56.8 kg) was added to the reactor in several portions over 20 hours. The mixture was adjusted to 35-45°C. The mixture was stirred, and nitrogen was bubbled through at 35-45°C for 1-2 hours. The reactor temperature was adjusted to 110-120°C, and hydrobromic acid in acetic acid (7.0 kg) was added to the reactor. The mixture was adjusted to 35-45°C. Process water (72 kg) and MTBE (43 kg) were added to the reactor at 15-25°C, and the mixture was stirred for 0.5-1.5 hours. The organic layer was separated and the aqueous layer was extracted with MTBE (12 kg). All organic layers were combined and adjusted to 0-10°C. The organic layer was then washed with 30% NaOH solution (68 kg) to adjust the pH of the mixture to 7-8. Water (10 kg) was added. The organic layer was separated and washed with 2% NaHCO3 aqueous solution (38 kg) and process water (12 kg). The organic layer was recycled through F909 with molecular sieves (6 kg) for 3-5 hours to remove water. After drying, the molecular sieves were washed with MTBE (20 kg). The organic solution was concentrated 2-3 times under reduced pressure below 50°C, and NBP (33 kg) was added. The mixture was concentrated under reduced pressure below 50°C to remove MTBE (<0.2%, SEPC: <2.0%). 6.16 kg of product (purity 99.0% A%) was obtained as an NBP solution in 90.1% yield.

[0240] Step 3: 6-bromo-N,N-bis(4-methoxybenzyl)-4-methyl-5-(trifluoromethyl)pyridin-2-amine

[0241] 2,6-Dibromo-4-methyl-3-(trifluoromethyl)pyridine (NBP) solution (6.16 kg, 1.00×, 1.0 equiv.) (assay corrected) was added to the reactor. (PMB)2NH (7.7 kg, 1.5 equiv.) and TEA (4.0 kg, 2.0 equiv.) were added to the reactor by pump addition. The reactor was adjusted to 70-75°C, stirred for 24 hours, and then adjusted to 45-55°C. The reactor was adjusted to 70-75°C, stirred for 8 hours, and then adjusted to 45-55°C. The mixture was adjusted to 45-55°C, and 20% aqueous citric acid solution (68.0 kg) was added to the reactor over 2-3 hours. The mixture was conditioned at 15-25°C for 1-2 hours, and the wet cake was isolated by centrifugation and rinsed with process water (30 kg) and methanol (11 kg) to yield 7.15 kg of wet cake. After drying under vacuum at 20-30°C for 20 hours, 7.15 kg of crude product was obtained.

[0242] Step 4: TIFF2026016384000121.tif23170

[0243] Crude 6-bromo-N,N-bis(4-methoxybenzyl)-4-methyl-5-(trifluoromethyl)pyridin-2-amine (7.15 kg, 1.00x) from step 2 and THF (31.15 kg) were added to the reactor. The mixture was decolorized with CUNO at 15-25 °C until a pale yellow color was obtained. The mixture was concentrated under reduced pressure at less than 40 °C to approximately 8.6 L. Methanol (6.79 kg) was added to the reactor. The reactor was adjusted to 45-55 °C, and then methanol (23.70 kg) and crystal seeds (71.5 g) were added to the reactor and stirred for 1 hour. Methanol (11.30 kg) was added to the reactor over 4 hours and stirred for 0.5 hours. The reactor was adjusted to 0°C over 2 hours, stirred for 18 hours, and the wet cake was isolated by filter and rinsed successively with methanol (11.30 kg) and heptane (4.86 kg). After drying under reduced pressure at 45°C for 18 hours, 6.75 kg of dry crude product was obtained.

[0244] 6.75 kg of the dried crude product from above and heptane (20.4 kg) were added to a reactor. The suspension was adjusted to 50°C and stirred at 50°C for 2 hours, then cooled to 0°C over 1 hour and stirred at 0°C for 16 hours. The suspension was filtered and rinsed with heptane (9.18 kg) to obtain a wet cake. The wet cake was dried in a single cone under reduced pressure at 50-55°C for 26 hours to obtain 6.2 kg of pure product.

[0245] Example 5: TIFF2026016384000122.tif42170

[0246] A solution of tert-butyl (3S)-4-[7-[6-[bis[(4-methoxyphenyl)methyl]amino]-4-methyl-3-(trifluoromethyl)-2-pyridyl]-6-chloro-2,8-difluoro-quinazolin-4-yl]-3-methyl-piperazine-1-carboxylate (50.0 g, 53.7 mmol, 1.00 equivalents, 87.3% assay) and [(2S)-1-methylpyrrolidin-2-yl]methanol (7.44 g, 64.6 mmol, 1.20 equivalents) in 2-Me-THF (320 g) was concentrated under reduced pressure (235 mbar) to 250 mL of solution. The solution was cooled to -10 ° C. Sodium tert-pentoxide (NaOt-Am) (24.8 g, 64.6 mmol, 1.30 equiv., 31% w / w) as a solution in toluene was then charged over 10–60 min. The reaction mixture was stirred at 0 °C until complete conversion was achieved (typically 1 h). The reaction mixture was then quenched with a stirred biphasic mixture of potassium carbonate (200 g, 10% w / w solution), N-acetyl-L-cysteine ​​(24 g, 16% w / w aqueous solution), and 2-Me-THF (107 g), maintaining the internal temperature at 15–30 °C. The biphasic mixture was stirred at 25 °C for 1–2 h, and the layers were separated. The organic layer was further washed with potassium carbonate (100 g, 10% w / w aqueous solution), and then the organic layer was concentrated under reduced pressure (235 mbar) to 250 mL of solution, cooled to 20–40 °C, and polish-filtered. The filtrate was further concentrated under reduced pressure (235 mbar) to a 175 mL solution. 1-PrOH (100 g) was added, and continuous exchange of 2-Me-THF with 1-PrOH was performed under reduced pressure (150-60 mbar). Water (100 g) was then added at 50 °C, and the solution was seeded at this temperature. The resulting mixture was further stirred at this temperature for at least 2 h, and water (100 g) was added over at least 2 h. The crystal slurry was cooled to 20 °C over at least 3 h and further stirred at this temperature for at least 5 h. The crystals were filtered off, washed with a 1-PrOH / water solution, and dried under reduced pressure to constant weight. The title compound was isolated as crystals in 96% yield (47.5 g). 11H NMR (600 MHz, DMSO-d6) δ ppm 7.82 (s, 1 H), 7.16 (d, J = 8.7 Hz, 4 H), 6.87 (br d, J = 8.3 Hz, 4 H), 6.82 (s, 1 H), 4.62 - 4.89 (m, 3 H), 4.56 (br d, J = 15.6 Hz, 2 H), 4.39 (dd, J = 10.7, 4.7 Hz, 1 H), 4.12 - 4.25 (m, 1 H), 4.05 (br d, J = 13.4 Hz, 1 H), 3.89 - 4.00 (m, 1 H), 3.76 - 3.84 (m, 1 H), 3.51 - 3.67 (m, 1 H), 2.88 - 3.18 (m, 2 H), 2.55 - 2.84 (m, 1 H), 2.27 - 2.43 (m, 5 H), 2.07 - 2.31 (m, 1 H), 1.85 - 2.00 (m, 1 H), 1.68 (br dd, J = 13.3, 7.9 Hz, 3 H), 1.42 (s, 9 H), 1.28 (br d, J = 6.6 Hz, 3 H) ppm. HR-MS (ESI): Calculated value C47H54ClF4N7O5 907.3811; Measured value: 907.3808.

[0247] Example 6: TIFF2026016384000123.tif44170

[0248] To a mixture of acetic acid (46.2 g), methanesulfonic acid (52.9 g), and toluene (34.7 g) at 40° C. was added a solution of tert-butyl (3S)-4-[7-[6-[bis[(4-methoxyphenyl)methyl]amino]-4-methyl-3-(trifluoromethyl)-2-pyridyl]-6-chloro-8-fluoro-2-[[(2S)-1-methylpyrrolidin-2-yl]methoxy]quinazolin-4-yl]-3-methyl-piperazine-1-carboxylate (20.0 g, 22.0 mmol) in toluene (86.7 g) over at least 15 minutes. The reaction mixture was then heated to 52° C. until complete conversion was achieved (typically 2 hours). The reaction mixture was then cooled to 25° C., and the layers were separated. The acidic layer was quenched slowly (typically over 1 h) at 40–55 °C with a mixture of aqueous sodium hydroxide (211.5 g, 28% w / w), water (80.0 g), and toluene (121.4 g). Once the quench was complete, acetic acid (10.0 g) was added to rinse the lines. The biphasic mixture was warmed to 50 °C, and the layers were separated. The organic layer was washed twice with aqueous sodium hydroxide (2 × 90.0 g, 0.1 N solution). The toluene layer was then vacuum distilled at constant volume (90 mbar; typically, 69 g of toluene was exchanged). After polish filtration, the resulting toluene solution was concentrated under reduced pressure (90 mbar) to a 94 mL solution, which was then warmed to 60 °C. n-Heptane (34.6 g) was then added over at least 30 min, and the solution was seeded at this temperature. The resulting mixture was further stirred at this temperature for at least 1 hour, and the crystal slurry was cooled to 0°C over at least 4 hours and further stirred at this temperature for at least 1 hour. The crystals were filtered off, washed with a toluene / n-heptane solution (1:1 v / v), and dried under reduced pressure to constant weight. The title compound was isolated as crystals in 89% yield (11.7 g). 1H NMR(600 MHz, DMSO-d6)δ ppm 7.74(d,J=0.9 Hz,1 H),6.84(s,2 H),6.49(s,1 H),4.54-4.65(m,1 H),4.38(dd,J=10.8,4.6 Hz,1 H),4.14(dd,J=10.7,6.5 Hz,1 H),3.96(br d,J=13.1 Hz,1 H),3.47-3.57(m,1 H),2.89-3.00(m,3 H),2.73-2.82(m,2 H),2.55-2.60(m,1 H),2.32-2.40(m,7 H),2.12-2.20(m,1 1.94 (dd, J=11.9, 7.6 Hz, 1 H), 1.67 (br d, J=8.3 Hz, 3 H), 1.40 (d, J=6.9 Hz, 3 H) ppm. HR-MS (ESI): Calculated value C26H30ClF4N7O 567.2136; Measured value: 567.2141.

[0249] Example 7: TIFF2026016384000124.tif105170

[0250] A solution of 3-(phenylsulfonyl)propionic acid (22.9 g, 106 mmol, 1.33 equiv.) and N-methylmorpholine (13.4 g, 133 mmol, 1.65 equiv.) in acetonitrile (180.7 g) was cooled to −10° C. Pivaloyl chloride (11.8 g, 97.9 mmol, 1.22 equiv.) was added over 30 minutes. The reaction mixture was further stirred at this temperature for 1 hour. Then, a solution of compound 1e (50.0 g, 80.4 mmol, 1.00 equiv.) in acetonitrile (176.9 g) was added to the cold reaction mixture over 1 hour and further stirred at −10° C. until complete conversion to the sulfone intermediate was achieved (typically 1 hour). The reaction mixture was warmed to 15°C and quenched by the addition of water (50.4 g), followed by aqueous sodium hydroxide (68.9 g, 483 mmol, 6.0 equiv., 28% w / w solution). Stirring was continued until complete conversion was achieved (typically 15 h), the mixture was seeded, and water (900 g) was then added over at least 2 h. The crystalline slurry was further stirred at this temperature for at least 42 h, and the crystals were filtered off, washed with a solution of acetonitrile / water (3:7 v / v), washed with water, and then dried under reduced pressure to constant weight. The title compound was isolated as crystals in 91% yield (45.6 g). 1H NMR(600 MHz,DMSO-d6)δ 7.82(s,1 H),6.73-6.98(m,3 H),6.50(s,1 H),6.10-6.28(m,1 H),5.68-5.81(m,1 H),4.66-4.85(m,1 H),4.32-4.46(m,1 H),4.25(br d,J=13.5 Hz,1 H),4.06-4.21(m,2 H),3.98(br d,J=13.4 Hz,1 H),3.38-3.76(m,2 H),2.91-3.27(m,2 H),2.53-2.68(m,1 H),2.37(br d,J=1.4 Hz,6 H), 2.11-2.26 (m, 1 H), 1.87-2.00 (m, 1 H), 1.56-1.79 (m, 3 H), 1.27 (br dd, J = 11.7, 6.7 Hz, 3 H) ppm. HR-MS (ESI): calculated for C29H32ClF4N7O2 621.2242; found: 621.2257.

[0251] Example 7a TIFF2026016384000125.tif166170

[0252] N-methylmorpholine (10.67 g, 1.65 equiv.) was added to a solution of 3-(phenylsulfonyl)propionic acid (18.91 g, 1.38 equiv.) in 2-Me-THF (136.6 g) at 20 °C. Pivaloyl chloride (9.56 g, 1.24 equiv.) was added over 30 min while maintaining the internal temperature between -20 and 0 °C. The reaction mixture was further stirred at this temperature for 1 h. Then, a solution of compound 1a (40.0 g, 1.00 equiv., 90.8% assay) and N-methylmorpholine (6.47 g, 1.00 equiv.) in 2-Me-THF (136.6 g) was added to the cold reaction mixture over 1 h and further stirred at -10 °C until complete conversion to the sulfone intermediate was achieved (typically 1 h). The reaction mixture was filtered and quenched by the addition of aqueous sodium hydroxide (31.2 g, 3.40 equiv., 28% w / w solution), followed by the addition of tetrabutylammonium chloride hydrate (3.55 g, 0.19 equiv.) and water (17.2 g) at 0–25°C. The reaction mixture was stirred at 20–30°C until complete conversion to compound 1 was achieved (typically 2.5 h), and aqueous sodium chloride (46.0 g, 20% w / w solution) was added. The layers were separated. The organic layer was washed successively with aqueous sodium bicarbonate (82.4 g, 5% w / w) and sodium chloride (82.4 g, 5% w / w). The organic layer was then concentrated under reduced pressure to a volume of 200 mL, and 2-Me-THF was exchanged until the desired water content was achieved, then cooled to 20°C. After polish filtration, the resulting 2-Me-THF solution was concentrated under reduced pressure to a 100 mL solution. 2-BuOH (307.9 g) was added at 35-45 °C, and adipic acid (10.28 g, 1.10 equiv.) was added at this temperature to give a solution. The solution was seeded at 30-40 °C and aged at this temperature for an additional 1.5 h. n-Heptane (161.4 g) was added to the crystal slurry over 30 min at 30-40 °C. The crystallization mixture was further aged at this temperature for at least 2 h and then cooled to 0 °C over at least 6 h. After aging at least 6 h at 0 °C, the crystals were filtered off, washed with a 2-BuOH / n-heptane solution (1:1 v / v), and dried under reduced pressure to constant weight. The title compound was isolated as crystals in 93% yield (45.2 g). 11H NMR (600 MHz, DMSO-d6) δ 7.77 (s, 1H), 6.81 (s, 2H), 6.76 (dd, J = 16.8, 10.6 Hz, 1H), 6.45 (s, 1H), 6.18 - 6.10 (m, 1H), 5.70 (dd, J = 10.4, 2.3 Hz, 1H), 4.75 - 4.66 (m, 1H), 4.38 - 4.30 (m, 2H), 4.25 - 3.89 (m, 4H), 3.61 (dq, J = 21.3, 12.4, 10.9 Hz, 2H), 3.20 (dd, J = 13.4, 3.8 Hz, 1H), 3.00 (td, J = 12.6, 3.7 Hz, 1H), 2.91 (ddd, J = 9.0, 6.0, 2.8 Hz, 1H), 2.59 - 2.51 (m, 1H), 2.32 (d, J = 6.2 Hz, 6H), 2.15 (td, J = 8.6, 7.7, 4.7 Hz, 5H), 1.94 - 1.85 (m, 1H), 1.61 (dddd, J = 20.8, 12.3, 8.0, 4.1 Hz, 3H), 1.45 (h, J = 3.4 Hz, 4H), 1.22 (dd, J = 12.4, 6.6 Hz, 3H); 13 C{<000​​​​​​​​​​​​​​Pivaloyl chloride (9.56 g, 1.24 equiv.) was added to a solution of 3-(phenylsulfonyl)propionic acid (18.91 g, 1.38 equiv.) in 2-Me-THF (136.6 g) at −20 to 0° C. N-methylmorpholine (10.67 g, 1.65 equiv.) was added slowly while maintaining the internal temperature at −20 to 0° C. The reaction mixture was further stirred at this temperature for 1 h. Then, a solution of compound 1a (40.0 g, 1.00 equiv., 90.8% assay) and N-methylmorpholine (6.47 g, 1.00 equiv.) in 2-Me-THF (136.6 g) was added to the cold reaction mixture over 1 h and further stirred at −10° C. until complete conversion to the sulfone intermediate was achieved (typically 1 h). The reaction mixture was filtered and quenched by the addition of aqueous sodium hydroxide (31.2 g, 3.40 equiv., 28% w / w solution), followed by the addition of tetrabutylammonium chloride hydrate (18.2 g, 0.94 equiv.) and water (17.2 g) at 0–25°C. The reaction mixture was stirred at 20–30°C until complete conversion to compound 1 was achieved (typically 1 h), and aqueous sodium chloride (46.0 g, 20% w / w solution) was added. The layers were separated. The organic layer was washed successively with aqueous sodium bicarbonate (82.4 g, 5% w / w) and sodium chloride (82.4 g, 5% w / w). The organic layer was then concentrated under reduced pressure to a volume of 200 mL, and 2-Me-THF was exchanged until the desired water content was achieved, then cooled to 20°C. After polish filtration, the resulting 2-Me-THF solution was concentrated under reduced pressure to a 100 mL solution. 2-BuOH (307.9 g) was added at 35-45 °C, and adipic acid (10.28 g, 1.10 equiv.) was added at this temperature to give a solution. The solution was seeded at 30-40 °C and aged at this temperature for an additional 1.5 h. n-Heptane (161.4 g) was added to the crystal slurry over 30 min at 30-40 °C. The crystallization mixture was further aged at this temperature for at least 2 h and then cooled to 0 °C over at least 6 h. After aging at least 6 h at 0 °C, the crystals were filtered off, washed with a 2-BuOH / n-heptane solution (1:1 v / v), and dried under reduced pressure to constant weight. The title compound was isolated as crystals in 85% yield (42.7 g). 11H NMR (600 MHz, DMSO-d6) δ 7.77 (s, 1H), 6.81 (s, 2H), 6.76 (dd, J = 16.8, 10.6 Hz, 1H), 6.45 (s, 1H), 6.18 - 6.10 (m, 1H), 5.70 (dd, J = 10.4, 2.3 Hz, 1H), 4.75 - 4.66 (m, 1H), 4.38 - 4.30 (m, 2H), 4.25 - 3.89 (m, 4H), 3.61 (dq, J = 21.3, 12.4, 10.9 Hz, 2H), 3.20 (dd, J = 13.4, 3.8 Hz, 1H), 3.00 (td, J = 12.6, 3.7 Hz, 1H), 2.91 (ddd, J = 9.0, 6.0, 2.8 Hz, 1H), 2.59 - 2.51 (m, 1H), 2.32 (d, J = 6.2 Hz, 6H), 2.15 (td, J = 8.6, 7.7, 4.7 Hz, 5H), 1.94 - 1.85 (m, 1H), 1.61 (dddd, J = 20.8, 12.3, 8.0, 4.1 Hz, 3H), 1.45 (h, J = 3.4 Hz, 4H), 1.22 (dd, J = 12.4, 6.6 Hz, 3H); 13 C{ 1 H, 19 F} NMR (151 MHz, DMSO-d6) δ 174.9, 165.5, 164.8, 162.2, 161.4, 153.2, 148.8, 147.7, 143.0, 131.1, 128.5, 128.4, 128.3, 128.2, 125.6, 125.3, 121.0, 114.7, 112.2, 110.5, 69.8, 63.9, 57.4, 52.5, 52.4, 49.4, 45.9, 45.2, 44.9, 44.3, 42.0, 41.7, 40.6, 34.0, 29.1, 24.6, 23.1, 20.3, 15.9, 15.3; 19 19F NMR (565 MHz, DMSO-d6) δ -53.5, -125.9.

[0255] <​​​​​​A 25 L reactor equipped with an active nitrogen line, overhead stirring, and a temperature probe was combined with Compound 1 (2.32 kg, 3.53 mol) and polish-filtered 2-butanone (17.42 L, 7.5 L / kg). A separate 5 L glass bottle was charged with adipic acid (0.46 kg, 3.17 mol, 0.9 equiv.) and polish-filtered 2-butanone (1.16 L, 0.5 L / kg). The reactor was then heated to 50°C ± 10°C. Once the desired internal temperature target of >45°C was reached, the adipic acid slurry in 2-butanone was charged to the reactor via vacuum. Compound B seed crystals (0.02 kg, 1 wt%) were charged to the 5 L glass bottle, followed by polish-filtered butanone (2.32 L, 1.0 L / kg). Again, the slurry was charged to the reactor via vacuum. Finally, the 5 L glass bottle was rinsed with polished filtered 2-butanone (1.16 L, 0.5 L / kg) and then vacuumed and charged to the reactor. The reactor contents were aged for a minimum of 1 hour, cooled to 0°C over a minimum of 2 hours, and then aged overnight (15 hours) at 0°C. The contents were transferred to a pre-cooled filter dryer at 0°C. In parallel, polished filtered 2-butanone (9.29 L, 4.0 L / kg) was charged to the reactor at 0°C and then stirred for 30 minutes. The material in the filter dryer was then filtered, and the resulting cake was washed with chilled 2-butanone. After drying for a minimum of 8 hours using vacuum and a nitrogen sweep, the contents of the filter dryer were discharged to yield Compound 1 adipate (2.137 kg, 77%) as a solid. 11H NMR (600 MHz, DMSO-d6) δ 7.77 (s, 1H), 6.81 (s, 2H), 6.76 (dd, J = 16.8, 10.6 Hz, 1H), 6.45 (s, 1H), 6.18 - 6.10 (m, 1H), 5.70 (dd, J = 10.4, 2.3 Hz, 1H), 4.75 - 4.66 (m, 1H), 4.38 - 4.30 (m, 2H), 4.25 - 3.89 (m, 4H), 3.61 (dq, J = 21.3, 12.4, 10.9 Hz, 2H), 3.20 (dd, J = 13.4, 3.8 Hz, 1H), 3.00 (td, J = 12.6, 3.7 Hz, 1H), 2.91 (ddd, J = 9.0, 6.0, 2.8 Hz, 1H), 2.59 - 2.51 (m, 1H), 2.32 (d, J = 6.2 Hz, 6H), 2.15 (td, J = 8.6, 7.7, 4.7 Hz, 5H), 1.94 - 1.85 (m, 1H), 1.61 (dddd, J = 20.8, 12.3, 8.0, 4.1 Hz, 3H), 1.45 (h, J = 3.4 Hz, 4H), 1.22 (dd, J = 12.4, 6.6 Hz, 3H); 13 C{ 1 H, 19 F} NMR (151 MHz, DMSO-d6) δ 174.9, 165.5, 164.8, 162.2, 161.4, 153.2, 148.8, 147.7, 143.0, 131.1, 128.5, 128.4, 128.3, 128.2, 125.6, 125.3, 121.0, 114.7, 112.2, 110.5, 69.8, 63.9, 57.4, 52.5, 52.4, 49.4, 45.9, 45.2, 44.9, 44.3, 42.0, 41.7, 40.6, 34.0, 29.1, 24.6, 23.1, 20.3, 15.9, 15.3; 19 19F NMR (565 MHz, DMSO-d6) δ -53.5, -125.9.

[0257] Example 9: TIFF2026016384000128.tif54170

[0258] Compound 1 (1 molar equivalent) and adipic acid (1 molar equivalent) were suspended in 2-butanol and 2-methyltetrahydrofuran and heated to approximately 70°C to dissolve. The polished filtered solution was cooled to approximately 25°C. Jet-milled Compound B material was used for seeding. Seed material Compound 1 adipate was suspended in 2-butanol / n-heptane. This suspension was used to seed the solution at approximately 25°C. The seeding equipment was rinsed with n-heptane, which was then added to the seed suspension. n-heptane was added at approximately 25°C within 15-30 minutes. The suspension was stirred at approximately 25°C for approximately 3 hours. The suspension was cooled to approximately 0°C and stirred for at least 5 hours. The solid was isolated by solid / liquid separation and rinsed with a mixture of 2-butanol / n-heptane, followed by n-heptane. The solid was dried under reduced pressure at approximately 40°C to obtain a powder in 88-95% yield.

[0259] In another procedure, compound 1 (1 molar equivalent) and adipic acid (1 molar equivalent or excess) were suspended in 2-butanol and 2-methyltetrahydrofuran and heated to approximately 70 °C to dissolve. The polished, filtered solution was cooled to the seeding temperature (approximately 25 °C). For seeding, the adipate salt of compound 1 was used without pretreatment or after impact milling, jet milling, or wet milling. The seeding material, the adipic acid salt of compound 1, was suspended in a solvent (n-heptane, a 2-butanol / n-heptane mixture, or 2-butanol). This suspension was used for seeding at the seeding temperature. The seeding equipment was rinsed with a solvent (n-heptane, a 2-butanol / n-heptane mixture, or 2-butanol), which was then added to the seed suspension. The n-heptane was added at the seeding temperature or a lower temperature (typically at approximately 25 °C) for approximately 15 to 30 minutes. The suspension was stirred at the n-heptane addition temperature for at least 3 hours. The suspension was cooled to approximately 0 °C and stirred for at least 5 hours. The solid was isolated by solid / liquid separation and rinsed with a mixture of 2-butanol / n-heptane, followed by n-heptane. The solid was dried under reduced pressure at approximately 40 °C to obtain a powder in 88-95% yield.

[0260] Example 10:

[0261] The adipate salt of compound 1 was heated to approximately 67°C and dissolved in 2-butanol and 2-methyltetrahydrofuran. The polished filtered solution was cooled to the seeding temperature (approximately 45°C). For seeding, wet-milled adipic acid compound 1 was used. The adipate salt of compound 1 was wet-milled in a solvent (n-heptane or a 2-butanol / n-heptane mixture). This suspension was used for seeding at the seeding temperature. The seeding equipment was rinsed with a solvent (n-heptane or a 2-butanol / n-heptane mixture, respectively), and then added to the seed suspension. Pre-cooled n-heptane (approximately 0°C) was added over a period of approximately 15 to 30 minutes. The cooled suspension was stirred at a temperature of approximately 25°C for at least 3 hours. The suspension was cooled to approximately 0°C and stirred for at least 2 hours. The solid was isolated by solid / liquid separation and rinsed with n-heptane or a mixture of 2-butanol / n-heptane, followed by n-heptane. The solid was dried under reduced pressure at approximately 40 °C, with yields ranging from 85 to 95%.

[0262] All technical and scientific terms used herein have the same meaning. Efforts have been made to ensure accuracy with respect to numbers used (e.g., amounts, temperatures, etc.), but some experimental error and deviation should be accounted for.

[0263] Throughout this specification and claims, the words "comprise," "comprises," and "comprising" are used in their non-exclusive sense, unless the context otherwise requires. It is understood that the embodiments described herein include embodiments "consisting of" and / or "consisting essentially of."

[0264] Where a range of values ​​is provided, unless the context clearly dictates otherwise, it is understood that each intervening value, to the tenth of the unit of the lower limit, between the upper and lower limit of that range and any other stated or intervening value in that stated range is encompassed herein. The upper and lower limits of these smaller ranges that may be independently included in smaller ranges are also encompassed herein, subject to any specifically excluded limit in the stated range. Where one or both of the limits is included in the stated range, ranges excluding either or both of those included limits are also included herein.

[0265] Many modifications and other embodiments of the inventions described herein will come to mind to one skilled in the art to which these inventions pertain having the benefit of the teachings presented in the foregoing descriptions and the associated drawings. It is to be understood, therefore, that the invention is not to be limited to the specific embodiments disclosed, and that modifications and other embodiments are intended to be included within the scope of the appended claims. Although specific terms are employed herein, they are used in a generic and descriptive sense only and not for purposes of limitation.

Claims

1. Formula (I); (In the formula, X １ and X ３ are each independently hydrogen or halogen; R １ is hydrogen or PG １ and Each R ２ are independently selected from halogen, cyano, unsubstituted C １－６ Alkyl, unsubstituted C １－６ cyanoalkyl, or unsubstituted C １－６ haloalkyl; R ３ is hydrogen, halogen, R ３Ａ -substituted or unsubstituted C １－３ Alkyl, R ３Ａ -substituted or unsubstituted C １－３ haloalkyl, or R ３Ａ - substituted or unsubstituted cyclopropyl; R ３Ａ is halogen, OH, CN, unsubstituted C １－３ Alkyl or unsubstituted C １－３ haloalkyl; R ４ is R ４Ａ -substituted or unsubstituted C １－３ haloalkyl; R ４Ａ is unsubstituted C １－３ is alkyl; n is 1 or 2; each PG is independently an amino protecting group; PG １ is an amino protecting group), or a solvate, tautomer, stereoisomer, atropisomer or salt thereof, comprising: The method comprises: (a) Formula (II) (In the formula, X ２ is a halogen) with an organomagnesium compound, thereby forming a compound of formula (IIa): forming a compound of formula (IIa), (b) transferring said compound of formula (IIa) of step (a) to a continuous stirred tank reactor (CSTR) containing a zinc compound, thereby producing a compound of formula (IIb): wherein m is 0, 1 or 2; p is 1, 2 or 3; X ２ is a halogen or OPiv; and (c) reacting the compound (IIb) of step (b) with a compound of formula (III) (In the formula, X ４ is a halogen, 1. A method comprising contacting a transition metal catalyst precursor with a chiral ligand, thereby synthesizing a compound of formula (I).

2. X ２ 2. The method of claim 1, wherein is Br, Cl, or OPiv.

3. wherein said compound of formula (II) (a) In the presence of a base, CO ２ Formula (IV) The compound (V) cyclizing to a compound of formula (I); (b) contacting said compound of formula (V) with a chlorinating agent, thereby forming a compound of formula (Va): synthesizing a compound of formula (I); (c) reacting the compound of step (b) with a compound of formula and contacting the piperazinyl moiety with a compound having the formula (Vb): synthesizing a compound of formula (I); and (d) contacting the compound of step (c) with a fluorinating agent in the presence of a base, thereby synthesizing a compound of formula (II).

3. The method according to claim 1 or 2, wherein the compound is prepared by a method (P2) comprising:

4. 4. The method of claim 3, wherein the base in step (a) is DBU.

5. The chlorinating agent in step (b) is POCl ３ The method of claim 3, wherein

6. 4. The method of claim 3, wherein the base in step (c) is DIPEA.

7. 4. The method of claim 3, wherein the fluorinating agent in step (d) is KF.

8. wherein said compound of formula (IV) (a) Formula (IVa) contacting a compound of formula (IVb) with i-PrMgCl, thereby forming a compound of formula (IVb) synthesizing a compound of formula (I); (b) contacting the compound of step (a) with hydroxylamine, thereby forming a compound of formula (IVc): synthesizing a compound of formula (I); (c) contacting the compound of step (b) with a base and a dehydrating agent in acetonitrile, thereby producing a compound of formula (IVd): synthesizing a compound of formula (I); (d) contacting the compound of step (c) with ammonia, thereby forming a compound of formula (IVe) synthesizing a compound of formula (I); and (e) contacting the compound of step (d) with a chlorinating agent, thereby synthesizing a compound of formula (IV). The method according to any one of claims 3 to 7, wherein the compound is prepared by a method (P3) comprising:

9. wherein said compound of formula (III) (a) (wherein, X ６ is Cl or I), with a halogenating agent to form a compound of formula (VIb) forming a compound of (b) brominating said compound of formula (VIb) to form a compound of formula (VI): forming a compound of the formula: (c) reacting said compound of formula (VI) with a compound of formula NH(PG) ２ with a compound having the formula (III) 2. The method of claim 1, wherein the compound is prepared by a method (P4) comprising:

10. X ６ 10. The method of claim 9, wherein is Cl.

11. The halogenating agent is SF in HF ４ The method of claim 9, wherein

12. 10. The method of claim 9, wherein the bromination is carried out using HBr in acid.

13. The compound of formula (III) has the formula: The method according to any one of claims 9 to 12, comprising:

14. X １ The method of any one of claims 1 to 13, wherein is a halogen.

15. X １ The method of any one of claims 1 to 13, wherein is F or Cl.

16. X ３ The method of any one of claims 1 to 13, wherein is a halogen.

17. X ３ The method of any one of claims 1 to 13, wherein is F or Cl.

18. R １ is PG １ The method according to any one of claims 1 to 17, wherein

19. PG １ is Ac (acetyl), trifluoroacetyl, Bn (benzyl), Tr (triphenylmethyl or trityl), benzylidenyl, p-toluenesulfonyl, PMB (p-methoxybenzyl), Boc (tert-butyloxycarbonyl), Fmoc (9-fluorenylmethyloxycarbonyl), or Cbz (carbobenzyloxy).

20. R １ The method according to any one of claims 1 to 19, wherein is Boc (tert-butyloxycarbonyl).

21. R ２ is unsubstituted C １－６ Alkyl or unsubstituted C １－６ 21. The method of any one of claims 1 to 20, wherein the alkyl group is cyanoalkyl.

22. R ２ The method of any one of claims 1 to 21, wherein is methyl.

23. R ３ is hydrogen or R ３Ａ -substituted or unsubstituted C １－３ The method of any one of claims 1 to 22, wherein the alkyl is alkyl.

24. R ３ The method of any one of claims 1 to 23, wherein is methyl.

25. R ４ But CF ３ , CHF ２ , or C.H. ２ The method according to any one of claims 1 to 24, wherein F.

26. R ３ is methyl, and R ４ is CF ３ The method according to any one of claims 1 to 25, wherein

27. 27. The method of any one of claims 1 to 26, wherein each PG is independently a protecting group selected from the group consisting of Ac (acetyl), trifluoroacetyl, phthalimide, Bn (benzyl), Tr (triphenylmethyl or trityl), benzylidenyl, p-toluenesulfonyl, DMB (dimethoxybenzyl), PMB (p-methoxybenzyl), Boc (tert-butyloxycarbonyl), Fmoc (9-fluorenylmethyloxycarbonyl), or Cbz (carbobenzyloxy).

28. 28. The method of claim 27, wherein each PG is p-methoxybenzyl.

29. 29. The method of any one of claims 1 to 28, wherein the organomagnesium compound is selected from the group consisting of isopropyl magnesium chloride, isopropyl magnesium bromide, isopropyl magnesium iodide, isopropyl magnesium chloride lithium chloride complex, sec-butyl magnesium chloride, lithium tri-n-butyl magnesiate, lithium triisopropyl magnesiate, and lithium (isopropyl)(di-n-butyl)magnesiate.

30. 30. The method of claim 29, wherein the organomagnesium compound is i-PrMgCl.LiCl.

31. The zinc compound is ZnCl ２ , ZnBr ２ , ZnI ２ , Zn(TFA) ２ , Zn(OAc) ２ , and Zn(OPiv) ２ The method of any one of claims 1 to 30, selected from the group consisting of:

32. The zinc compound is Zn(OPiv). ２ The method of claim 31, wherein the base is LiCl.

33. The transition metal catalyst precursor is a Pd or Ni catalyst precursor, and Pd(OAc) ２ , PdCl ２ , PdCl ２ (MeCN) ２ , Pd(benzonitrile) ２ Cl ２ , Pd(dba) ２ , Pd ２ (dba) ３ , Pd(PPh ３ ) ４ , Pd(PCy ３ ) ２ , Pd(PtBu ３ ) ２ , Pd(TFA) ２ , [Pd(allyl)Cl] ２ [Pd(cinnamyl)Cl] ２ , [PdCl(crotyl)] ２ , PdCl(η5-cyclopentadienyl), [(η3-allyl)(η5-cyclopentadienyl)palladium(II)], [Ni(η5-cyclopentadienyl)(allyl)], [bis(1,5-cyclooctadiene)nickel(0)], NiCl ２ , NiBr ２ , Ni(OAc) ２ 32. The method of any one of claims 1 to 31, wherein the cation is selected from the group consisting of:

34. The chiral ligand is (In the formula, Y is O or NR ７ and R ７ and R ８ are independently unsubstituted C １－６ The method of any one of claims 1 to 32, wherein the aryl group is alkyl.

35. R ７ and R ８ 35. The method of claim 34, wherein

36. R ７ and R ８ 35. The method of claim 34, wherein each is independently methyl, ethyl, or phenyl.

37. 35. The method of any one of claims 1 to 34, wherein the chiral ligand is an (R,R)-chiraphite ligand.

38. The zinc compound is Zn(OPiv). ２ LiCl, and the Pd catalyst precursor is [Pd(cinnamyl)Cl] ２ and the chiral ligand is an (R,R)-chiraphite ligand.

39. The compound of formula (I) has the formula:

2. The method of claim 1, comprising:

40. The compound of formula (I) has the formula: (Ie) (wherein X ３ 10. The method of claim 1 , wherein

41. The compound of formula (I) has the formula:

10. The method of claim 1, comprising: (11).

42. Formula (2) A method (P5) for synthesizing the compound of (2), comprising: The method comprises: (a) Formula (4a) is contacted with i-PrMgCl and subsequently with hydroxylamine, thereby forming a compound of formula (4c) synthesizing a compound of formula (I); (b) contacting the compound of formula (4c) with TFAA and triethylamine in acetonitrile, followed by contact with ammonia, thereby producing a compound of formula (4e): synthesizing a compound of formula (I); (c) contacting said compound of formula (4e) with a chlorinating agent, thereby forming a compound of formula (4): synthesizing a compound of formula (I); (d) reacting the compound (4) with CO in the presence of DBU ２ and contacting the compound of formula (5) with synthesizing a compound of formula (I); (e) reacting the compound of formula (5) with POCl ３ and DIPEA, followed by contact with tert-butyl (S)-3-methylpiperazine-1-carboxylate in DIPEA, thereby producing a compound of formula (5b): synthesizing a compound of formula (I); and (f) contacting the compound of (5b) with KF, DABCO and MsOH, thereby forming a compound of formula (2). A method (P5) comprising:

43. The compound of formula (III) has the formula: (3) The compound of formula (3) (a) Formula (6a) The compound ４ and HF, thereby forming a compound of formula (6b) synthesizing a compound of formula (I); (b) contacting the compound of formula (6b) with HBr in AcOH to form a compound of formula (6): forming a compound of (c) reacting the compound of formula (6) with (PMB) ２ NH, triethylamine and NBP, thereby synthesizing a compound of formula (III). The method according to claim 1, wherein the compound is synthesized by method (P6), which comprises:

44. Formula (G) by method (P7) (In the formula, X Ａ teeth, 10. The method of claim 1, further comprising synthesizing a compound of formula (I) selected from the group consisting of: The method comprises: (a) reacting the compound of formula (I), or a solvate, tautomer, stereoisomer, atropisomer or salt thereof, with X Ａ with a moiety comprising: (b) obtaining a PG group and optionally an R group from said compound of formula (G1) １ and (c) reacting the compound of step (b) with the compound of formula (VII) in the presence of an activating agent followed by contacting with a base, thereby producing a compound of formula (G), or a tautomer, stereoisomer, atropisomer, or pharmaceutically acceptable salt thereof. A method comprising:

45. Formula: (1) or a pharmaceutically acceptable salt thereof (P9), said method comprising: (a) Formula (2) or a salt thereof with a pre-cooled solution containing i-PrMgCl.LiCl using a flow rate that provides a residence time for the Mg—Br exchange of about 15 to 150 seconds; (b) ZnCl ２ or Zn(OPiv) ２ transferring the mixture of step (a) to a continuous stirred tank reactor (CSTR) containing a pre-cooled solution of (c) reacting the mixture of step (b) with NaTFA and a compound represented by formula (3) with a compound of formula (I); (d) contacting the mixture of step (c) or a salt thereof with a Pd or Ni catalyst precursor and a chiral ligand, thereby forming a compound of formula (11): or a solvate or salt thereof, (e) reacting the compound of formula (11), or a solvate or salt thereof, with a compound of formula HO-X Ａ (In the formula, X Ａ is an expression and a base, whereby the compound has the formula (1b); or a solvate or a pharmaceutically acceptable salt thereof; (f) contacting said compound of formula (1b) with MsOH in acid, thereby forming a compound of formula (1a); or a solvate or pharmaceutically acceptable salt thereof; and (g) reacting the compound of formula (1a) or a solvate or a pharmaceutically acceptable salt thereof in the presence of an activating agent. and subsequently contacting with a base, thereby producing a compound of formula (1), or a pharmaceutically acceptable salt thereof (P9).

46. 46. ​​The method of claim 45, wherein the acid in step (f) is AcOH, trifluoroacetic acid, chlorosulfonic acid, sulfuric acid, HCl, HBr, p-toluenesulfonic acid, or trifluoromethanesulfonic acid.

47. 46. ​​The method of claim 45, wherein compound (2) is synthesized according to the method of claim 42.

48. The pre-cooled solution of step (b) contains Zn(OPiv). ２ 46. ​​The method of claim 45, comprising LiCl.

Images