Information processing system, information processing method, and program

Abstract

To objectively determine an execution degree of an intervention plan related to a living activity of a user.SOLUTION: The information processing system includes a control unit. The controller acquires first plan information indicating a first plan of a predetermined intervention relating to a living activity of a user, acquires a change index indicating a change in an expression level of a variable gene before and after the intervention according to the first plan of the user, the variable gene having an expression level that changes due to the intervention, and determines an execution level of the first plan based on the first plan information and the change index.SELECTED DRAWING: Figure 8

Description

[Technical Field]

[0001] The present invention relates to an information processing system, an information processing method, and a program for determining the degree of implementation of an intervention related to a user's lifestyle behavior, such as improving dietary habits or increasing the amount of exercise. [Background technology]

[0002] There have been systems for supporting users in improving their health. For example, Patent Document 1 below discloses a system in which a user is asked questions about their physical condition, dietary information, lifestyle information, needs information, etc. using a medical questionnaire or questionnaire, and further a physical fitness test is conducted, and a health improvement program including two types of endurance training and muscle strength training that are individually suited to the user's physical condition, dietary status, and lifestyle status is created in accordance with the user's needs. The user performs the health improvement program and reports the amount of activity each time to a center, and the center analyzes and judges the amount of activity and provides advice based on the results. [Prior art documents] [Patent documents]

[0003] [Patent Document 1] Japanese Patent Application Laid-Open No. 2004-54591 Summary of the Invention [Problem to be solved by the invention]

[0004] The technology in Patent Document 1 receives reports from the user about the amount of activity while executing the health promotion program that has been created, and provides advice based on that information, but it is unclear whether the user is actually executing the health promotion program as created.

[0005] An object of the present invention is to provide an information processing system, an information processing method, and a program that are capable of objectively determining the degree of implementation of an intervention plan related to a user's daily activities. [Means for solving the problem]

[0006] An information processing system according to one aspect of the present invention includes a control unit that acquires first plan information indicating a first plan for a predetermined intervention related to a user's daily behavior, acquires a change index indicating a change in expression level of a variable gene before and after the intervention according to the first plan for the user, the change index being used to determine a degree of execution of the first plan based on the first plan information and the change index for the variable gene whose expression level changes as a result of the intervention, and

[0007] An information processing method according to another aspect of the present invention includes: acquiring plan information indicating a predetermined intervention plan for the user's daily living activity; For variable genes whose expression levels change due to the intervention, a change index is obtained that indicates a change in the expression level of the variable genes before and after the intervention according to the user's plan; Determining the degree of execution of the plan based on the plan information and the change index.

[0008] According to yet another aspect of the present invention, there is provided a program for executing the program on an information processing device, acquiring plan information indicating a predetermined intervention plan for the user's daily living activity; For variable genes whose expression levels change due to the intervention, a step of obtaining a change index indicating a change in the expression level of the variable genes before and after the intervention according to the user's plan; and determining the degree of execution of the plan based on the plan information and the change index. [Effects of the Invention]

[0009] According to an information processing system according to an embodiment of the present invention, it is possible to objectively determine the degree of implementation of an intervention plan for a user's daily activities. However, this effect does not limit the present invention. [Brief explanation of the drawings]

[0010] [Figure 1]1 is a diagram showing a configuration of a diet information providing system according to an embodiment of the present invention. [Figure 2] 1 is a diagram showing a hardware configuration of a diet information providing server according to an embodiment of the present invention. [Figure 3] 2 is a diagram showing the configuration of a database included in a diet information providing server according to one embodiment of the present invention. FIG. [Figure 4] 1 is a table showing a list of genes whose expression levels increase before and after intervention, among variable genes used by a diet information providing server according to one embodiment of the present invention to determine the degree of implementation of a dietary intervention plan. [Figure 5] 1 is a table showing a list of genes whose expression levels decrease before and after intervention, among variable genes used by a diet information providing server according to one embodiment of the present invention to determine the degree of implementation of a dietary intervention plan. [Figure 6] 10 is a table showing a list of genes whose expression levels increase before and after an exercise intervention, among variable genes used by a diet information providing server according to one embodiment of the present invention to determine the degree of implementation of an exercise intervention plan. [Figure 7] 10 is a table showing a list of genes whose expression levels decrease before and after an exercise intervention, among variable genes used by a diet information providing server according to one embodiment of the present invention to determine the degree of implementation of an exercise intervention plan. [Figure 8] 10 is a flowchart showing the flow of a diet plan proposal process by a diet information providing server according to one embodiment of the present invention. DETAILED DESCRIPTION OF THE INVENTION

[0011] Hereinafter, an embodiment of the present invention will be described with reference to the drawings.

[0012] [System Configuration] As shown in FIG. 1, this system includes a diet information providing server 100 on the Internet 50, a plurality of user terminals 200, and a testing institution terminal 300 owned by a testing institution (including a medical institution).

[0013] The diet information providing server 100 provides a diet plan proposal service for users of user terminals 200. Specifically, the diet information providing server 100 is connected to a plurality of user terminals 200 via the Internet 50, determines the degree of implementation of a first diet plan that involves a predetermined intervention (dietary intervention, exercise intervention, etc.) related to the user's lifestyle behavior, and transmits proposal information proposing a new second diet plan to the user terminal 200 based on the determination result. The degree of implementation of the first diet plan is determined based on a change index that indicates the change before and after the intervention in the expression level of variable genes whose expression levels change specifically between before and after the intervention.

[0014] Here, "dietary intervention" refers to, for example, a registered dietitian providing dietary advice every two weeks for two months to reduce the user's energy intake with the goal of losing 3% of the user's current body weight. However, dietary intervention may also be at least one of the following, and the diet information providing server 100 can set the definition of dietary intervention by appropriately combining these. Eat less (set a daily calorie intake) Reduce snacking or eat healthier snacks Reduce the amount of carbohydrates (staple foods) you consume Reduce fat intake Reduce sugar in drinks Increase your intake of fruits and vegetables Eat meals at regular times -Don't eat late at night (e.g. after 8pm) Limit the time during the day when you can eat (for example, 10 hours) Stop eating when you are 80% full Replace at least one meal a day with a menu designed specifically for dieting (for example, a menu that reduces fat and increases protein, replaces fat with omega-3, and includes carbohydrates with dietary fiber).

[0015] Furthermore, "exercise intervention" refers to, for example, exercise instruction given every two weeks for two months by a fitness instructor to increase energy expenditure with the goal of losing 3% of current body weight. However, exercise intervention may also be at least one of the following, and the diet information providing server 100 can set the definition of exercise intervention by appropriately combining these. Engage in a set number of minutes (e.g., at least 150-300 minutes) of moderate-intensity (3.0-6.0 METs) physical activity per week (e.g., brisk walking, dancing, mowing the lawn). Engage in vigorous-intensity (6.0 METs or greater) physical activity (e.g., running, swimming, stair climbing) for a set period of time (e.g., at least 75-150 minutes) per week. · Perform prescribed strength training (e.g., 15 minutes of multiple strength training such as squats) a prescribed number of times per week (e.g., 3 times) Other activities that involve increasing the intensity and / or duration of daily physical activity or exercise

[0016] Other examples of "prescribed interventions" include sleep interventions, smoking cessation interventions, posture correction interventions, acupressure interventions (e.g., ear acupressure), and breathing interventions.

[0017] Furthermore, the "change index" of the expression level of a fluctuating gene is, for example, the ratio of expression levels before and after intervention (between the start and end of intervention) (expression level ratio), or the amount of change in expression level before and after intervention (fluctuating expression level) or rate of change, but is not limited to these.

[0018] The user terminals 200 (200A, 200B, 200C...) are terminals used by users, such as smartphones, mobile phones, tablet PCs (Personal Computers), notebook PCs, desktop PCs, etc. The user terminals 200 transmit the user's diet plan proposal request information to the diet information providing server 100, receive the diet plan information, and display it on a screen using a browser or the like. An application corresponding to the diet prediction effect information providing service may also be installed in the user terminals 200, and the user terminals 200 may access the diet information providing server 100 using the application to display the diet plan information.

[0019] Furthermore, information regarding the change index can be transmitted to the diet information providing server 100 from a terminal of the testing institution that performed the test regarding the expressed gene or from a user terminal 200 that received information from the testing institution.

[0020] The testing institution terminal 300 is, for example, a smartphone, a mobile phone, a tablet PC, a notebook PC, a desktop PC, or the like, and measures the expression levels of the expressed genes before and after the intervention of the user of the user terminal 200, generates information indicating the change index, and transmits it to the diet information providing server 100. The testing institution terminal 300 may transmit the measured expression level information before and after the intervention directly to the diet information providing server 100, instead of the information indicating the change index.

[0021] [Hardware configuration of diet information server] As shown in FIG. 2, the diet information providing server 100 includes a CPU (Central Processing Unit) 11, a ROM (Read Only Memory) 12, a RAM (Random Access Memory) 13, an input / output interface 15, and a bus 14 connecting these components to one another.

[0022] The CPU 11 accesses the RAM 13 etc. as needed, and performs various arithmetic processing while controlling all blocks of the diet information providing server 100 in an integrated manner. Multiple CPUs 11 may be provided depending on the processing. The ROM 12 is a non-volatile memory in which firmware such as the OS, programs, and various parameters to be executed by the CPU 11 are permanently stored. The RAM 13 is used as a working area for the CPU 11, and temporarily stores the OS, various applications currently being executed, and various data currently being processed.

[0023] The input / output interface 15 is connected to a display unit 16, an operation reception unit 17, a storage unit 18, a communication unit 19, and the like.

[0024] The display unit 16 is a display device that uses, for example, an LCD (Liquid Crystal Display), an OLED (Organic ElectroLuminescence Display), a CRT (Cathode Ray Tube), or the like.

[0025] The operation reception unit 17 is, for example, a pointing device such as a mouse, a keyboard, a touch panel, or other input device. When the operation reception unit 17 is a touch panel, the touch panel can be integrated with the display unit 16.

[0026] The storage unit 18 is a non-volatile memory such as a hard disk drive (HDD), a flash memory (solid state drive (SSD)), or other solid-state memory. The storage unit 18 stores the OS, various applications, and various data.

[0027] As will be described later, particularly in this embodiment, the storage unit 18 has a user information database, an expression amount information database, and a diet plan information database in addition to programs such as applications required for the diet plan proposal process described later.

[0028] The communication unit 19 is, for example, a NIC (Network Interface Card) for Ethernet or various modules for wireless communication such as wireless LAN, and is responsible for communication processing with the user terminal 200.

[0029] Although not shown, the basic hardware configuration of the user terminal 200 is also substantially the same as the hardware configuration of the diet information providing server 100 described above.

[0030] [Database configuration of diet information server]

[0031] 3, the diet information providing server 100 has a user information database 31, an expression amount information database 32, and a diet plan information database 33 in the storage unit 18. Note that each of these databases may be stored in a storage device or server externally connected to the diet information providing server 100, rather than in the storage unit 18.

[0032] The user information database 31 stores general information such as the user's name, age, sex, user ID for identifying the user, occupation, address, email address, as well as physical information such as the user's height, weight, body composition, visceral fat area, waist size, blood pressure, heart rate, body temperature, etc. In addition, information regarding the user's preferences regarding diet and exercise may also be stored.

[0033] Additionally, the user information database 31 may store information on responses to questionnaires given to users. The questionnaires may be about, for example, the user's lifestyle habits, health status, or personality. Questionnaires regarding lifestyle habits include the BDHQ (Brief Self-Administered Diet History Questionnaire), the International Standardized Physical Activity Questionnaire, and the Eating Behavior Questionnaire. Questionnaires regarding health status include the 35-item Diet Questionnaire, the WHO-5 Mental Health Status Questionnaire, the Occupational Stress Brief Questionnaire, the Chalder Fatigue Scale, the Athens Insomnia Scale, and the Self-Efficacy Questionnaire. Questionnaires regarding personality include the Big-five questionnaire.

[0034] The expression level information database 32 stores information about the expression levels of the user's expressed genes measured by the testing institution for each user ID. As described above, the information about the expression levels may be data showing the expression level ratio, the fluctuating expression level, or the rate of change of a specific gene before and after intervention with the diet plan for the user, or data showing the expression levels of each gene before and after intervention.

[0035] The expression level information database 32 also stores information indicating a reference expression level ratio, which will be described later, for each piece of information identifying a variable gene (gene ID). Furthermore, the expression level information database 32 also stores a threshold value for determining whether the expression level ratio measured by the user is sufficiently close to the reference expression level ratio (whether the degree of implementation of the diet plan is as expected). The threshold value is set to, for example, 90% or more of the reference expression level ratio.

[0036] The diet plan information database 33 stores information indicating diet plans created for users of the user terminal 200. Specifically, for diet plans involving dietary intervention, the information includes the menu for each meal, the amount, intake time (frequency), ingredients, and calorie intake. For diet plans involving exercise intervention, the information includes the exercise menu (type of exercise), exercise intensity, duration, frequency, time of execution, and calories burned. As will be described later, multiple diet plans can be proposed to each user, taking into account the degree to which the user is adhering to the plan.

[0037] These databases are used by mutual reference as needed in the diet plan proposal process by the diet information providing server 100, which will be described later.

[0038] [Variable genes] Next, we will explain the variable genes whose expression levels change before and after the above-mentioned intervention.

[0039] The inventors measured the gene expression levels of subjects before and after dietary and exercise interventions and found that there are genes whose expression levels fluctuate specifically before and after dietary intervention (intake restriction fluctuating genes) and genes whose expression levels fluctuate specifically before and after exercise intervention (consumption promotion fluctuating genes).

[0040] An intake restriction-varying gene is at least one gene whose expression level varies with energy intake restriction behavior but does not vary with energy consumption-promoting behavior. The intake restriction-varying gene functions as a marker for determining whether a subject is engaging in energy intake restriction behavior. Furthermore, a "gene whose expression level varies with energy intake restriction behavior but does not vary with energy consumption-promoting behavior" refers to a gene whose expression level or its expression product is shown to increase or decrease statistically significantly in gene expression data before and after an intervention in a subject group in which only energy intake restriction behavior is intervened, and whose expression level or its expression product is shown not to change statistically significantly in gene expression data before and after an intervention in a subject group in which only energy consumption-promoting behavior is intervened.

[0041] The intake restriction fluctuating gene is composed of at least one gene selected from the group consisting of intake restriction increasing genes whose expression levels increase due to energy intake restriction behavior and intake restriction decreasing genes whose expression levels decrease due to energy intake restriction behavior. Specifically, intake restriction increasing genes are genes whose expression levels have been shown to significantly increase before and after intervention based on data from a subject population in which only the above-mentioned energy intake restriction behavior was intervened. Similarly, intake restriction decreasing genes are genes whose expression levels have been shown to significantly decrease before and after intervention based on data from a subject population in which only the above-mentioned energy intake restriction behavior was intervened.

[0042] The gene that increases intake restriction preferably consists of at least one gene selected from the group consisting of 34 genes: KIAA0146, FBXW4, LRP11, TCEA3, ANXA9, SPINK7, DGCR6L, CA13, THOC3, MYL9, RPIA, TPRG1, FAM83H, AGR2, DANCR, FAM108B1, RAB11FIP5, RPL13, TSNARE1, TFAP2A, EPHA2, NDUFA4L2, JMJD8, RASD2, PMM1, SNX21, NCK2, ALOX12B, RAB38, BSCL2, HRAS, CNKSR3, GLE1, and CDKN1C.

[0043] The gene that reduces intake restriction preferably consists of at least one gene selected from the group consisting of 23 genes: CCDC82, LOC646214, TMEM14E, C5orf15, CCNL1, NRARP, LOC145474, IFIH1, RNF2, CRLF2, ITPRIPL2, LOC100303749, PRPF40A, MTSS1, CLNS1A, MEF2A, RB1, ANKRD44, ZNF292, NXF1, ARID4B, ZCRB1, and LPAR6.

[0044] Each of the 57 intake restriction variation genes is a gene that was shown to have a significantly increased or decreased mRNA expression level in the data from a group of subjects who underwent a dietary management instruction program (dietary intervention) and were certified to have complied with the instructions in the program (hereinafter referred to as the "homogeneous dietary intervention group"), and a group of subjects who underwent an instruction program to increase physical activity (exercise intervention) and were certified to have complied with the instructions in the program (hereinafter referred to as the "homogeneous exercise intervention group"), in the data from the homogeneous dietary intervention group before and after the dietary intervention, and to have no significant change in mRNA expression level in the homogeneous exercise intervention group before and after the exercise intervention, and to have a ratio of RNA expression level before and after the dietary intervention that was more than 2-fold or less than 1 / 2. Therefore, each of the 57 intake restriction variation genes can function as a marker for determining the implementation of energy intake restriction behavior equivalent to dietary intervention.

[0045] A consumption-promoting variable gene is at least one gene whose expression level does not change with energy intake restriction behavior, but whose expression level changes with energy consumption-promoting behavior. The consumption-promoting variable gene functions as a marker for determining whether a subject is engaging in energy consumption-promoting behavior. Furthermore, a "gene whose expression level does not change with energy intake restriction behavior, but whose expression level changes with energy consumption-promoting behavior" refers to a gene whose expression level or its expression product shows a statistically significant increase or decrease in gene expression data from a subject group that has been intervened with only energy consumption-promoting behavior, and whose expression level does not show a statistically significant change in gene expression data from a subject group that has been intervened with only energy intake restriction behavior before and after the intervention.

[0046] The consumption promotion variable gene is composed of at least one gene selected from the group consisting of consumption promotion increasing genes whose expression levels increase due to energy consumption promoting behavior and consumption promotion decreasing genes whose expression levels decrease due to energy consumption promoting behavior. Specifically, the consumption promotion increasing genes are genes whose expression levels have been shown to significantly increase before and after the intervention based on data from a subject group in which only the above energy consumption promoting behavior was intervened. Similarly, the consumption promotion decreasing genes are genes whose expression levels have been shown to significantly decrease before and after the intervention based on data from a subject group in which only the above energy consumption promoting behavior was intervened.

[0047] The consumption-promoting gene is preferably at least one gene selected from the group consisting of 41 genes: SCEL, KIAA0284, BARX2, S100A2, KRTAP1-5, CAMK2N1, KRT13, PIP, AIF1L, GBAP1, KRTAP3-3, PRKCZ, EVPL, WBSCR22, ARG1, KRTAP5-10, SEPP1, PLK2, KRT6C, GSDMC, PLEKHG1, CDC42BPG, MAST4, GOLGA7B, CGA, SDR16C5, ARHGAP23, ATP6V0A4, RERE, KLC3, CGN, RAPGEF5, OSBPL1A, MAL, FMN1, CXADR, OCLN, COQ9, NIPAL4, BAIAP2L1, and SH3GL3.

[0048] The consumption-promoting reducing gene preferably comprises at least one gene selected from the group consisting of the following five genes: LOC100506888, OR11H12, LOC349196, USP17L6P, and USP17L5.

[0049] Each of the 46 consumption-promoting variable genes is a gene whose mRNA expression level was significantly increased or decreased in the data before and after exercise intervention in a homogeneous group of exercise-intervention subjects, whose mRNA expression level was not significantly changed in the data before and after dietary intervention in a homogeneous group of dietary intervention subjects, and whose RNA expression level ratio before and after the exercise intervention was more than 2-fold or less than 1 / 2. Therefore, each of the 46 consumption-promoting variable genes can function as a marker for determining whether or not an energy consumption-promoting behavior equivalent to exercise intervention has been performed.

[0050] Furthermore, the expression levels of the intake restriction variable gene and / or consumption promotion variable gene, or their expression products, are preferably derived from a non-invasively collected biological sample such as skin surface lipids (SSL), which allows for easier collection of the biological sample and reduces the burden on the subject compared to using an invasively collected biological sample such as blood.

[0051] As described above, the diet information providing server 100 determines the degree of implementation of the first diet plan involving dietary intervention and / or exercise intervention based on the change index of the expression level of the above-mentioned variable genes before and after the intervention, and based on the determination result, transmits to the user terminal 200 proposal information suggesting a new second diet plan to the user.

[0052] Specifically, if it is determined that the degree of implementation is below a predetermined level, diet suggestion information is generated that proposes a second diet plan with a higher degree of intervention than the first diet plan (a dietary intervention plan that further restricts energy intake or an exercise intervention plan that further promotes energy consumption).

[0053] The predetermined degree as a threshold for the above judgment can be set based on the numerical range that can be taken by the expression level and / or change index of each variable gene or its expression product, or the value or range calculated by substituting the numerical value indicating the expression level and / or its change index into a predetermined mathematical formula.

[0054] More specifically, the specified degree may be calculated as the degree of the expression level ratio of each variable gene actually measured before and after the user's intervention, relative to the average expression level ratio (reference expression level ratio) of each variable gene before and after the intervention at an intermediate point (one month after the intervention) when the goal of the dietary intervention or exercise intervention for a specified period (e.g., two months) (e.g., a 3% reduction in current body weight) is achieved.

[0055] When two or more variable genes are used as assessment markers, the predetermined degree may further include, in addition to the conditions set for each gene, a condition for the number or proportion of intake restriction variable genes that satisfy the condition, or a condition for the number or proportion of consumption promotion variable genes that satisfy the condition.As another example, when two or more genes are used as assessment markers, the predetermined degree may be set as a value or a range thereof calculated by substituting values ​​indicating the expression levels and / or change indexes corresponding to each of the multiple genes into a predetermined mathematical formula.

[0056] The present inventors conducted the following tests to select the above-mentioned variable genes.

[0057] 1) Study participants BMI of 23 kg / m 2 120 adult men (aged 20 to 60 years) who met the eligibility criteria for the study were selected as participants in the dietary intervention group, which will undergo the dietary intervention described below. 113 adult men under the same conditions were selected as participants in the exercise intervention group, which will undergo the exercise intervention described below.

[0058] 2) Collection of lipids on the skin surface Before and after the intervention study described below, skin surface lipids (SSL) containing RNA were collected from the entire face of the study participants using oil blotting film.

[0059] 3) Pre-intervention testing A physical examination was conducted as a pre-intervention test before the intervention test described below. Note that the examination in this test example was conducted with the consent of the test participants.

[0060] Participants were invited to a designated venue for a physical examination, which included height, weight, body composition (fat mass, lean mass, muscle mass, MQP, determined bone mass, total body water (TBW), total body water percentage (TBW%), body fat percentage, SMI (appendicular muscular index), trunk body fat percentage, trunk body fat mass, trunk lean mass, trunk muscle mass, etc.), visceral fat area, abdominal circumference, blood pressure, pulse, and body temperature.

[0061] 4) Implementation of dietary intervention Next, the participants in the dietary intervention group underwent a two-month dietary intervention. Specifically, a registered dietitian provided each participant with dietary advice every two weeks to reduce their energy intake in order to achieve their target weight (a 3% reduction from their current weight). Each participant was instructed to record their daily meals using an application program that allows them to record their dietary intake. In addition, each participant was instructed to measure their daily activity level using a provided activity tracker and not to consciously increase their exercise level. After the two-month dietary intervention, the participants in the dietary intervention group underwent a post-intervention physical examination similar to the pre-intervention examination.

[0062] 5) Selection of subjects for the dietary intervention group Of the 112 participants in the dietary intervention group who completed the two-month dietary intervention, 65 participants who were judged to have achieved adequate dietary management (50% or more of the daily target energy reduction over the entire two-month period) and had not significantly changed their physical activity were selected as a homogeneous group for analysis. Changes in dietary intake were determined using the food records in the application program, and physical activity was determined based on the results of activity measurements.

[0063] 6) Implementation of exercise intervention Meanwhile, the exercise intervention group also underwent a two-month exercise intervention. Specifically, a fitness instructor provided each participant with exercise instruction once every two weeks to increase energy expenditure and achieve a target weight (a 3% reduction from their current weight). Each participant was instructed to keep a daily exercise log (diary) and to measure and record their daily activity using a provided activity monitor. In addition, each participant was instructed to record their daily meal intake using the above-mentioned application program and not to consciously change their diet. After the two-month exercise intervention, the exercise intervention group participants underwent a post-intervention physical examination similar to the pre-intervention examination.

[0064] 7) Selection of subjects for the exercise intervention group Of the 97 participants in the exercise intervention group who completed the two-month exercise intervention, 77 participants who were judged to have achieved a sufficient amount of exercise (more than 50% of the target exercise amount over the entire two months) and not have made any significant changes in their dietary intake were selected as a homogeneous group for analysis. Daily exercise records (diaries) were used primarily to determine exercise intake, with activity measurement results used as secondary evidence. Changes in dietary intake were determined using food records from the above application program.

[0065] 8) RNA preparation and sequencing The oil blotting film was cut to the appropriate size, and RNA was extracted using a tissue lysis reagent. The extracted RNA was reverse-transcribed at 42°C for 90 minutes to synthesize cDNA. A library containing DNA derived from the 20802 gene was prepared from the resulting cDNA by multiplex PCR. The resulting PCR product was purified, followed by buffer reconstitution, primer digestion, adapter ligation, purification, and amplification to prepare a library. The prepared library was loaded onto a chip and sequenced using a sequencer. The gene from which each read sequence originated was determined by genetic mapping of each read sequence to the human genome reference sequence.

[0066] 9) Data preprocessing The read counts of each read obtained by sequencing the subjects' SSL-derived RNA obtained in 8) above were used as expression level data for each RNA, and the normalized count values ​​were used for analysis. In the dietary intervention group, data from 56 subjects in whom 30% or more of all detected gene species were detected were used for the following analysis. In the exercise intervention group, data from 65 subjects in whom 30% or more of all detected gene species were detected were used for the following analysis.

[0067] 10) Extraction of genes whose expression levels change with dietary and / or exercise intervention Using data from subjects in the dietary intervention group that had undergone data preprocessing, genes with statistically significant changes in expression between RNA expression levels before and after dietary intervention were extracted from genes (5987 genes) for which non-missing expression data was available for more than 90% of subjects. These genes were extracted based on an adjusted p-value (threshold < 0.05) that controlled the false discovery rate (FDR) between the two groups (before and after dietary intervention).

[0068] Similarly, using the data of subjects in the exercise intervention group that had undergone data preprocessing, genes whose expression levels showed statistically significant changes between RNA expression levels before and after exercise intervention were extracted from among the genes (6,817 genes) for which non-missing expression data was obtained for more than 90% of subjects.

[0069] As a result, 271 differentially expressed genes were extracted in common from the data of both the dietary intervention group and the exercise intervention group, of which 228 genes showed increased expression after the weight loss intervention compared to before, and 43 genes showed decreased expression after the weight loss intervention compared to before. Furthermore, 822 differentially expressed genes were extracted only from the data of the dietary intervention group, but not from the data of the exercise intervention group, of which 401 genes showed increased expression after the dietary intervention compared to before, and 421 genes showed decreased expression after the dietary intervention compared to before. Furthermore, 298 differentially expressed genes were extracted only from the data of the exercise intervention group, but not from the data of the dietary intervention group, of which 212 genes showed increased expression after the exercise intervention compared to before, and 86 genes showed decreased expression after the exercise intervention compared to before.

[0070] 11) Extraction of genes whose expression changes are specific to dietary and exercise interventions For each gene selected in 10), the ratio of RNA expression level after weight loss intervention to RNA expression level before weight loss intervention (RNA expression level after weight loss intervention / RNA expression level before weight loss intervention) was calculated as the expression level ratio (Fold Change: FC) from the RNA expression level data. Note that the "RNA expression level" for genes with expression changes extracted commonly from the data of the dietary intervention group and the exercise intervention group was taken as the average RNA expression level for all subjects used in the analysis of both groups. The "RNA expression level" for genes with expression changes extracted only from the data of the dietary intervention group was taken as the average RNA expression level for all subjects used in the analysis of the dietary intervention group. The "RNA expression level" for genes with expression changes extracted only from the data of the exercise intervention group was taken as the average RNA expression level for all subjects used in the analysis of the exercise intervention group.

[0071] From the genes selected in 10), genes that satisfied FC>2 or FC<1 / 2 (i.e., genes whose RNA expression levels changed more than two-fold before and after the weight-loss intervention) were extracted. As a result, no genes with expression changes were commonly extracted from the data of the dietary intervention group and the exercise intervention group. Furthermore, 57 genes with expression changes were extracted only from the data of the dietary intervention group, but not from the data of the exercise intervention group. Of these, 34 genes showed increased expression after the intervention compared to before, and 23 genes showed decreased expression after the intervention compared to before. Furthermore, 46 genes with expression changes were extracted only from the data of the exercise intervention group, but not from the data of the dietary intervention group. Of these, 41 genes showed increased expression after the intervention compared to before, and 5 genes showed decreased expression after the intervention compared to before.

[0072] 12) Selection of genes that alter intake restriction Of the genes extracted in 11), genes with expression changes extracted only from the data of the dietary intervention group were designated as intake restriction-varying genes, whose expression levels changed due to energy intake restriction behavior (dietary intervention) but not due to energy consumption-promoting behavior (exercise intervention).Of the intake restriction-varying genes, genes whose expression levels increased due to energy intake restriction behavior (dietary intervention) were designated as intake restriction-increasing genes, and genes whose expression levels decreased due to energy intake restriction behavior (dietary intervention) were designated as intake restriction-decreasing genes.

[0073] The selected genes that increase intake restriction are 34 genes: KIAA0146, FBXW4, LRP11, TCEA3, ANXA9, SPINK7, DGCR6L, CA13, THOC3, MYL9, RPIA, TPRG1, FAM83H, AGR2, DANCR, FAM108B1, RAB11FIP5, RPL13, TSNARE1, TFAP2A, EPHA2, NDUFA4L2, JMJD8, RASD2, PMM1, SNX21, NCK2, ALOX12B, RAB38, BSCL2, HRAS, CNKSR3, GLE1, and CDKN1C.

[0074] The genes that were selected to reduce intake restriction were 23 genes: CCDC82, LOC646214, TMEM14E, C5orf15, CCNL1, NRARP, LOC145474, IFIH1, RNF2, CRLF2, ITPRIPL2, LOC100303749, PRPF40A, MTSS1, CLNS1A, MEF2A, RB1, ANKRD44, ZNF292, NXF1, ARID4B, ZCRB1, and LPAR6.

[0075] 13) Selection of consumption-promoting variable genes Of the genes extracted in 11), genes with expression changes extracted only from the data of the exercise intervention group were designated as consumption-promoting variable genes, whose expression levels change with energy consumption-promoting behavior (exercise intervention) but do not change with energy intake-restricting behavior (dietary intervention).Of the consumption-promoting variable genes, genes whose expression levels increase with energy consumption-promoting behavior (exercise intervention) were designated as consumption-promoting increasing genes, and genes whose expression levels decrease with energy consumption-promoting behavior (exercise intervention) were designated as consumption-promoting decreasing genes.

[0076] The selected genes that promote consumption were SCEL, KIAA0284, BARX2, S100A2, KRTAP1-5, CAMK2N1, KRT13, PIP, AIF1L, GBAP1, KRTAP3-3, PRKCZ, EVPL, WBSCR22, ARG1, KRTAP5-10, SEPP1, PLK2, KRT6C, GSDMC, PLEKHG1, CDC42BPG, MAST4, GOLGA7B, CGA, SDR16C5, ARHGAP23, ATP6V0A4, RERE, KLC3, CGN, RAPGEF5, OSBPL1A, MAL, FMN1, CXADR, OCLN, COQ9, NIPAL4, BAIAP2L1, and SH3GL3.

[0077] The five genes that were selected for reducing consumption promotion were LOC100506888, OR11H12, LOC349196, USP17L6P, and USP17L5.

[0078] 14) Calculation of the expression ratio (FC) For each subject in the dietary intervention group, the expression ratio (FC) of each intake restriction variable gene selected in 12) before and after the dietary intervention was calculated. Similarly, for each subject in the exercise intervention group, the expression ratio (FC) of each consumption promotion variable gene selected in 13) before and after the exercise intervention was calculated.

[0079] 15) Counting the number of subjects From the results of 14), for each gene that increases with intake restriction, the number of subjects with an expression level ratio (FC) value greater than 1 was counted, and for each gene that decreases with intake restriction, the number of subjects with an expression level ratio (FC) value less than 1 was counted. Similarly, from the results of 14), for each gene that increases with consumption promotion, the number of subjects with an expression level ratio (FC) value greater than 1 was counted, and for each gene that decreases with consumption promotion, the number of subjects with an expression level ratio (FC) value less than 1 was counted. An expression level ratio (FC) value greater than 1 means that the expression level has increased due to the weight loss intervention, and an expression level ratio (FC) value less than 1 means that the expression level has decreased due to the weight loss intervention.

[0080] 16) Verification of the accuracy of diet behavior assessment For each gene with elevated intake restriction, the percentage of subjects counted as having an expression level ratio (FC) greater than 1 among all subjects analyzed in the dietary intervention group was calculated as the detection rate (Figure 4). Similarly, for each gene with reduced intake restriction, the percentage of subjects counted as having an expression level ratio (FC) less than 1 among all subjects analyzed in the dietary intervention group was calculated as the detection rate (Figure 5). Similarly, for each gene with elevated consumption promotion, the percentage of subjects counted as having an expression level ratio (FC) greater than 1 among all subjects analyzed in the exercise intervention group was calculated as the detection rate (Figure 6). Similarly, for each gene with reduced consumption promotion, the percentage of subjects counted as having an expression level ratio (FC) less than 1 among all subjects analyzed in the exercise intervention group was calculated as the detection rate (Figure 7). The results are shown in Figures 4 to 7. Note that FC in Figures 4 to 7 is the FC of each gene calculated in 11).

[0081] As described below, the diet information providing server 100 receives information indicating the expression levels of these variable genes before and after intervention, or information indicating the expression level ratio, calculated by the testing institution, from the testing institution terminal 300 or the user terminal 200, and determines the degree of implementation of the diet plan due to the intervention.

[0082] [Operation of diet information server] Next, the operation of the diet information providing server 100 configured as above will be described. The operation is performed by the cooperation of hardware such as the CPU 11 and communication unit 19 of the diet information providing server 100 and software stored in the storage unit 18. For convenience, in the following description, the CPU 11 is the subject of the operation.

[0083] FIG. 8 is a flowchart showing the flow of the process for providing the diet effect prediction information.

[0084] As shown in the figure, first, the CPU 11 determines whether or not a diet plan proposal request has been received from the user terminal 200 (step 81).

[0085] If it is determined that a diet plan proposal request has been received (Yes in step 81), the CPU 11 transmits first diet plan information proposing a first diet plan to the user terminal 200 (step 82). Here, the first diet plan may be a plan (dietary intervention plan or exercise intervention plan) predetermined according to, for example, information about each user (age, sex, weight, height, etc.) stored in the user information database 31. Furthermore, the user may select whether they wish to receive dietary intervention or exercise intervention when making the diet plan proposal request, and the selection information may be transmitted from the user terminal 200 together with the proposal request.

[0086] When requesting a diet plan proposal, the user is assumed to visit a testing institution and undergo testing (measurement of SSL-derived RNA expression levels) for the expression levels of the above-mentioned variable genes before intervention (before implementing the diet plan). The variable genes are determined to be at least one of the genes shown in Figures 4 to 7 above, depending on whether the first diet plan involves dietary intervention (Figures 4 and 5) or exercise intervention (Figures 6 and 7). Note that the test may be conducted by mailing a biological sample (such as sebum) instead of visiting a testing institution.

[0087] The user follows the menu (meals or exercise) included in the first diet plan information, records the details of the meals or exercise using the application as described above, and then, at a predetermined period (e.g., one month) within the period (e.g., two months) specified by the first diet plan information, visits a testing institution to have the expression levels of the variable genes tested (measurement of the expression levels of SSL-derived RNA) after the intervention period (after the diet plan is implemented).

[0088] Next, the CPU 11 determines whether or not expression level ratio data before and after the intervention has been received from the testing institution terminal 300 (step 83). The expression level ratio data includes information (gene ID) for identifying the variable gene whose expression level was measured.

[0089] If it is determined that the expression level ratio data has been received (Yes in step 83), the CPU 11 refers to the expression level information database 32 and determines the degree of implementation of the first diet plan from the received expression level ratio and the reference expression level ratio corresponding to the gene ID (step 84). That is, the CPU 11 calculates the degree of implementation of the first diet plan as the degree of implementation of the first diet plan, based on the received expression level ratio relative to the reference expression level ratio.

[0090] Next, the CPU 11 determines whether the calculated execution degree is equal to or less than a predetermined degree (the threshold value) (step 85).

[0091] If it is determined that the degree of implementation is greater than the predetermined degree (No in step 85), it is considered that the first diet plan is being implemented as planned, and the CPU 11 terminates the process. In this case, the CPU 11 may send a message such as "Progressing according to plan. Let's keep it up" to the user terminal 200 and display it on the application.

[0092] On the other hand, if it is determined that the implementation level is equal to or lower than the predetermined level (Yes in step 85), the CPU 11 generates second diet plan information that proposes a second diet plan with a higher level of intervention than the first diet plan (step 86). The generated second diet plan information is stored in the diet plan information database 33.

[0093] That is, if the first diet plan is a dietary intervention, the CPU 11 generates a second diet plan that, for example, restricts the amount of energy intake from meals more than the first diet plan (for example, by reducing the amount of each meal menu). Also, if the first diet plan is an exercise intervention, the CPU 11 generates a second diet plan that, for example, promotes energy consumption through exercise more than the first diet plan (for example, by increasing the intensity or duration of each exercise menu).

[0094] In this case, the extent to which energy intake is restricted or energy consumption is promoted may be determined according to the degree of implementation calculated above (for example, restricting / promoting by the inverse of the degree of implementation calculated above), or a plan may be set in advance that restricts energy intake by a predetermined amount or promotes energy consumption by a predetermined amount more than the first diet plan.

[0095] Then, the CPU 11 transmits the second diet plan information to the user terminal 200 (step 87). The user follows this second diet plan for the remaining period of the diet implementation period.

[0096] In this example, the diet period is divided into two and the degree of implementation is judged at the end of the first half, but it may also be divided into more periods and further diet plans (a third diet plan, a fourth diet plan, etc.) may be generated depending on the results of the assessment of the degree of implementation at the end of each period.

[0097] As described above, according to this embodiment, the diet information providing server 100 can objectively determine the degree of implementation of the user's diet plan and propose a new diet plan accordingly.

[0098] [Variations] Although the embodiments of the present invention have been described above, the present invention is not limited to the above-described embodiments, and it goes without saying that various modifications can be made within the scope of the gist of the present invention.

[0099] In the above-described embodiment, the first diet plan and the second diet plan are either dietary intervention or exercise intervention. However, the first diet plan and the second diet plan may include both dietary intervention and exercise intervention.

[0100] In this case, when the diet information providing server 100 determines that the degree of implementation of the first diet plan is equal to or less than the predetermined degree, it may generate a second diet plan that implements at least one of reducing energy intake and increasing energy expenditure compared to the first diet plan. That is, compared to the first diet plan, the second diet plan may reduce energy intake and maintain energy expenditure, maintain energy intake and increase energy expenditure, or reduce energy intake and increase energy expenditure. In this case, the amount of reduction in energy intake or the amount of increase in energy expenditure may be determined according to the degree of implementation, as in the above-mentioned embodiment, or may be set to a predetermined amount.

[0101] Furthermore, the second diet plan may be one that reduces energy intake to reduce energy expenditure, or one that increases energy intake to increase energy expenditure, compared to the first diet plan. In this case, the rate of decrease / increase in energy intake and the rate of decrease / increase in energy expenditure may be the same, or the rate of decrease in energy intake may be set to be greater than the rate of decrease in energy expenditure, or the rate of increase in energy expenditure may be set to be greater than the rate of increase in energy intake.

[0102] In the above-described embodiment, the dietary intervention or exercise intervention is implemented to help the user lose weight, but the dietary intervention or exercise intervention may also be implemented for weight gain rather than weight loss. For example, for a user who loses weight despite not wanting to lose weight (such as a sumo wrestler or a user who needs to gain weight for some reason), the diet information providing server 100 may determine the degree of intervention for weight gain from the expression level ratio to determine why the user is losing weight (whether they are not eating enough or exercising too much), and may provide appropriate advice for building a physique (such as eating more or exercising less).

[0103] In the above embodiment, the diet information providing server 100 proposes a first diet plan for the user, but the first diet plan may be created by the user. In this case, the diet information providing server 100 receives the first diet plan information and the expression level ratio data before and after the intervention from the user terminal 200, determines the implementation degree, and if it determines that the implementation degree is below a predetermined level, may send the second diet plan information to the user terminal 200. In this way, the diet plan information providing server 100 allows the user to create their own diet plan, objectively visualize the correctness and implementation rate, and provide a program that can be customized and improved by the user.

[0104] In the above-described embodiment, in the case of dietary intervention, the diet information providing server 100 generates a second diet plan in which the portions of each meal menu are reduced compared to the first diet plan. Alternatively, the diet information providing server 100 may generate information proposing a second diet plan in which the ingredients or dishes are changed from those in the first diet plan. The change in ingredients or dishes may be, for example, a change to a menu with less carbohydrates or fats. In this case, the meals for dietary intervention may be prepared and delivered by a company affiliated with the diet information providing server 100. This allows the diet information providing server 100 to determine whether the meal content is appropriate for the user at that time and deliver more appropriate foods to the user.

[0105] In the above-described embodiment, the diet information providing server 100 generates a second diet plan in the case of exercise intervention, in which the intensity of each exercise menu is increased or the duration is extended compared to the first diet plan. Alternatively, the diet information providing server 100 may generate information proposing a second diet plan in which the type of exercise is changed from the first diet plan. This change in the type of exercise may be, for example, changing anaerobic exercise to aerobic exercise or vice versa.

[0106] In the above-mentioned embodiment, the diet information providing server 100 did not generate the second diet plan when it determined that the implementation degree of the first diet plan was greater than a predetermined degree.Instead, when the diet information providing server 100 determined that the implementation degree of the first diet plan was greater than a predetermined degree, it further determines whether the measured expression amount ratio is greater than the above-mentioned reference expression amount ratio or a threshold value set to a value slightly greater than it, and if it is greater than the threshold value, it is considered that the diet is over-paced, so it may generate information to propose a second diet plan with a lower intervention level than the first diet plan.

[0107] In the above-described embodiment, the diet information providing server 100 determines whether the degree of implementation of the first diet plan is equal to or less than a predetermined degree. Alternatively, the diet information providing server 100 may continuously acquire expression level ratio data for the same user multiple times and determine whether the multiple expression level ratios are maintained constant. This allows the diet information providing server 100 to perform compliance determination regarding whether the user is complying with the dietary intervention or exercise intervention.

[0108] In the above embodiment, the diet information providing server 100 may receive from the user terminal 200 answer information in response to a question asking whether the user has implemented the first diet plan, and determine whether the user has provided a false answer to the answer information based on the answer information and the determination result of the implementation degree. This allows the diet information providing server 100 to evaluate the user's personality (reliability, humanity).

[0109] In the above-described embodiment, the degree of implementation of a diet plan for a general (obese) user is determined, but the present invention can also be applied to other programs, such as a program for determining whether a user is correctly implementing a dietary therapy for treating diabetes when receiving dietary restriction guidance for treating a disease (diabetes). It can also be used to manage nutrition and exercise guidance for day care centers and elderly people (people with dementia), and to diagnose the developmental status of infants and children (whether parents are providing their children with enough food to grow).

[0110] Furthermore, in the field of developing a device that estimates a user's calorie intake or calorie expenditure, the present invention may be applied to evaluate the accuracy of the estimation (without actually measuring the user's calorie intake or calorie expenditure).

[0111] In the above-mentioned embodiment, the diet information providing server 100 judges the execution level by the ratio of the received expression amount ratio to the above-mentioned reference expression amount ratio. Alternatively, the diet information providing server 100 may generate a discrimination model by machine learning to determine whether the execution level is according to the plan (and if not according to the plan, to what stage), based on the expression amount ratio, and use the discrimination model to determine the execution level.

[0112] In the above-described embodiment, the diet information providing server 100 generated the second diet plan based on the expression level ratio without referring to the actual obesity improvement effect of the user's first diet plan. Alternatively, the diet information providing server 100 may generate information proposing the second diet plan by referring to the actual obesity improvement effect of the user (reduction effect of body weight, body fat mass, body fat area, etc.) in addition to the expression level ratio. For example, if the first diet plan is a plan involving only dietary intervention and the expression level ratio indicates that the degree of implementation of the first diet plan is equal to or greater than the predetermined degree, but the user has not actually lost weight, the diet information providing server 100 may generate information proposing a second diet plan that adds exercise intervention to dietary intervention.

[0113] In the above-described embodiments, the intervention was dietary intervention or exercise intervention, but the intervention is not limited to these. For example, the interventions of the present invention also include sleep intervention, smoking cessation intervention, posture correction intervention, acupressure intervention (e.g., ear acupressure), breathing technique intervention, etc. In this case, at least one of the above-described variable genes may be selected for each intervention and selected as a measurement target. Furthermore, in the above-described embodiments, a diet plan based on dietary intervention or exercise intervention was proposed. Alternatively, a lifestyle guidance plan that is more advanced than a diet plan and includes dietary intervention, exercise intervention, and other interventions may be proposed.

[0114] In the above-described embodiment, the diet information providing server 100 receives a diet plan proposal request from the user terminal 200 and transmits diet plan information to the user terminal 200. However, the diet information providing server 100 may receive a diet plan proposal request from a proxy user terminal of a proxy user who acts as a proxy for the user of the user terminal 200 and transmit diet plan information to the proxy user terminal. Here, the proxy user terminal is, for example, a terminal of a business operator (such as a health checkup business operator representative or a gym trainer) that is between the user and the diet information providing server 100, but is not limited to this.

[0115] In the above embodiment, only one diet information providing server 100 is shown, but the processes executed by the diet information providing server 100 may be distributed and executed by a plurality of servers.

[0116] Among the inventions described in the claims of this application, the invention described as an "information processing method" is one in which each step is automatically performed by at least one device such as a computer through software-based information processing, and is not performed by a human using a device such as a computer. In other words, the "information processing method" is an information processing method using computer software, and is not a method in which a human operates a computing tool called a computer. [Explanation of symbols]

[0117] 11...CPU 18...Storage section 19…Communications Department 31...User information database 32...Expression information database 33...Diet plan information database 100...Diet information server 200...User terminal 300...Inspection agency terminal

Claims

1. acquiring first plan information indicating a first plan of a predetermined intervention regarding the user's daily living behavior; For variable genes whose expression levels change due to the intervention, a change index is obtained that indicates a change in the expression level of the variable genes before and after the intervention according to the first plan of the user; Determining the degree of execution of the first plan based on the first plan information and the change index Control Unit An information processing system comprising:

2. The control unit generating proposal information that proposes to the user a second plan for the predetermined intervention that is different from the first plan based on the determination result of the degree of execution of the first plan; Output the generated proposal information The information processing system according to claim 1 .

3. When the control unit determines that the execution degree is equal to or less than a predetermined degree, the control unit generates the proposal information that proposes, as the second plan, a plan with a higher degree of intervention than the first plan. The information processing system according to claim 2 .

4. the predetermined intervention is a dietary intervention or an exercise intervention; The control unit generates the proposal information that proposes, as the second plan, a meal plan that restricts energy intake more than the first plan or an exercise plan that promotes energy consumption more than the first plan. The information processing system according to claim 3 .

5. the predetermined intervention is a dietary intervention and an exercise intervention; The variable genes include intake restriction variable genes whose expression levels are changed by energy intake restriction behavior and whose expression levels are not changed by energy consumption promotion behavior, and consumption promotion variable genes whose expression levels are not changed by the energy intake restriction behavior and whose expression levels are changed by the energy consumption promotion behavior, In the first plan, an energy intake amount in the dietary intervention and an energy expenditure amount in the exercise intervention are set, The control unit generates the proposal information proposing, as the second plan, a plan to execute at least one of increasing or decreasing the energy intake amount and increasing or decreasing the energy consumption amount compared to the first plan. The information processing system according to claim 3 .

6. The control unit receiving the first plan information and information regarding the change index from the user terminal of the user; The generated proposal information is transmitted to the user terminal. The information processing system according to claim 2 .

7. the predetermined intervention is a dietary intervention, and the first plan has information about ingredients or dishes to be consumed by the user; When the control unit determines that the execution degree is equal to or lower than a predetermined degree, the control unit generates the proposal information that proposes, as the second plan, a plan in which the ingredients or the dish are changed from the first plan. The information processing system according to claim 2 .

8. the predetermined intervention is an exercise intervention, and the first plan has information about a type of exercise to be performed by the user; When the control unit determines that the execution degree is equal to or lower than a predetermined degree, the control unit generates the proposal information that proposes, as the second plan, a plan in which the type of exercise is changed from that of the first plan. The information processing system according to claim 2 .

9. When the control unit determines that the execution degree is greater than a predetermined degree, the control unit generates the proposal information that proposes, as the second plan, a plan with a lower degree of intervention than the first plan. The information processing system according to claim 2 .

10. The control unit continuously acquires the change indicators for the same user multiple times and determines whether the multiple change indicators are maintained constant. The information processing system according to claim 1 .

11. The control unit receiving, from the user terminal of the user, answer information in response to a question inquiring whether the user has executed the first plan; Based on the answer information and the determination result of the degree of execution, it is determined whether the user has provided a false answer to the answer information. The information processing system according to claim 1 .

12. acquiring plan information indicating a predetermined intervention plan for the user's daily living activity; For variable genes whose expression levels change due to the intervention, a change index is obtained that indicates a change in the expression level of the variable genes before and after the intervention according to the user's plan; The degree of execution of the plan is determined based on the plan information and the change index. Information processing methods.

13. In the information processing device, acquiring plan information indicating a predetermined intervention plan for the user's daily living activity; For variable genes whose expression levels change due to the intervention, a step of obtaining a change index indicating a change in the expression level of the variable genes before and after the intervention according to the user's plan; determining the degree of execution of the plan based on the plan information and the change index; A program that executes the following.

Images