Composition for skin care

Abstract

The skin care composition provides a skin care composition capable of interacting with enzymes in the stoma output, thereby reducing enzyme activity.SOLUTION: A skin care composition comprising at least 1 wt.% potato protein, a first binder comprising a polar or non-polar polymer or copolymer in an amount of 20 to 70 wt.%, and 20 to 80 wt.% solids.SELECTED DRAWING: None

Description

[Technical Field]

[0001] Skin care compositions capable of reducing enzymatic activity in stomal output are provided. [Background technology]

[0002] Stoma patients often use skin care compositions to treat or prevent peristomal skin damage. The skin care composition may be incorporated into the stoma appliance or may be used as a separate composition, for example in the form of a lotion, cream, or gel.

[0003] Stoma output contains enzymes known to damage skin. These enzymes can be addressed with compositions that interact with the enzymes, thereby reducing their activity. For example, in the process, the enzymes are removed from the mixture by interacting with a compound, so that they cannot cause skin damage.

[0004] The peristomal area is characterized by mechanical stress due to patient movement, as well as sweat and body heat. Furthermore, stoma output provides an environment with high enzyme activity. Skin care compositions should be formulated to address these environmental factors while maintaining good skin care properties. Furthermore, skin care compositions should avoid excessive absorption of water, which can increase the enzyme concentration in the output. Summary of the Invention [Means for solving the problem]

[0005] Thus, there is provided a skin care composition comprising at least 15% by weight of potato protein, a first binder comprising a polar or non-polar polymer or copolymer in an amount of 20-50% by weight, and 20-65% by weight of solids, wherein the total content of potato protein, clay and other solids is in the range 50-75% by weight.

[0006] There is also provided the use of a skin care composition as defined herein in the peristomal environment. A particular use of the skin care composition is for reducing enzymatic activity, in particular trypsin activity, in the stoma output.

[0007] Methods are provided for preventing skin damage and / or maceration.Methods are provided for reducing enzymatic activity in stoma output.

[0008] Also provided is a stoma appliance comprising a skin care composition as defined herein. Also provided is a faceplate for a stoma appliance comprising a skin care composition as defined herein. DETAILED DESCRIPTION OF THE INVENTION

[0009] Thus, in an embodiment, a. at least 1% by weight of potato protein; b. a first binder comprising a polar or non-polar polymer or copolymer in an amount of 20 to 70 wt. %; c. 20 to 65 wt. % of a clay-containing solid; A skin care composition comprising:

[0010] Upon exposure to stoma output or water, the clay is washed out of the skin care composition into the environment where it can interact with enzymes from the stoma output, thereby reducing enzymatic activity.

[0011] The inventors have found that when designing a skin care composition, it is necessary to balance several properties: (a) the texture of the composition; (b) the expansion (swelling) of the composition when it comes into contact with moisture; (c) the release of clay from the composition; and (d) the enzyme activity reducing effect of the composition, all of which are affected by the amount of potato protein and clay in the composition.

[0012] The inventors have found that to obtain an acceptable texture, the total content of potato protein, clay, and other solids should be in the range of 50-75% (w / w): below 50% (w / w) a composition that was too soft and runny was obtained, while above 75% (w / w) a composition that was too hard.

[0013] The inventors further found that a minimum of 20% (w / w) clay was beneficial in achieving the desired enzyme activity reduction. Adding more clay could increase enzyme activity reduction, but this was problematic due to increased swelling of the composition when exposed to moisture. To address this undesirable swelling, the inventors turned to potato protein. It was surprisingly found that adding potato protein made it possible to control the swelling of the composition without compromising the enzyme-reducing activity. Indeed, it was surprisingly found that potato protein not only inhibited the swelling caused by the clay, but also contributed to a slower and more steady release of the clay from the composition, resulting in better control of the enzyme-reducing activity of the composition. In an aspect, the invention relates to a skin care composition comprising at least 15% by weight of potato protein, a first binder comprising a polar or non-polar polymer or copolymer in an amount of 25-50% by weight, and 20-60% by weight of solids comprising clay, wherein the total content of potato protein, clay and other solids is in the range of 50-75% by weight.

[0014] In embodiments, the skin care composition has a texture that allows it to be applied to a stoma appliance, so that it can stay in place without flowing during storage, but at the same time, when exposed to stoma output, it can erode and potato proteins and optional solids can be washed away. In embodiments, the composition has a dough-like texture that allows it to be molded into a desired form, such as a layer or coating, but is still soft enough to follow the movement of the appliance. When using a mixture of powders / particles and one or more binders, it is difficult to avoid syneresis of the resulting composition. Syneresis is a process in which a gel exudes liquid upon contact when left standing, like the separation of whey in cheese making.

[0015] In embodiments, the skin care composition has low expansion when wetted. If the skin care composition is located near the stoma, the large expansion of the composition upon exposure to stoma output may cause undesirable pressure on the stoma. The presence of potato protein in the composition may slow wetting of the composition, thereby increasing the time it takes for the composition to be washed off. Furthermore, when potato protein is present, the swelling of the clay may proceed more slowly.

[0016] The skin care composition is preferably non-adhesive so that it does not interfere with or adhere to other components of the stoma appliance.

[0017] In embodiments, it is desirable to have a composition that is cohesive, has a texture that is resistant to syneresis or can flow during storage, exhibits limited swelling during absorption of stoma output, and still allows the potato protein and clay to be washed away during wear time. Designing a composition with these properties is a delicate balance.

[0018] "Output" refers to the effluent from the stoma, which may be feces and / or urine in a more or less viscous form, possibly accompanied by mucin secreted by the epithelial lining of the digestive tract. In the case of a colostomy, the output may be entirely solid, while an ileostomy may produce a more liquid output. The output may contain digestive fluids with enzymes and other components that may be invasive to the skin and thus cause skin maceration and contact dermatitis. The output may also contain components, such as deposits, that may invasively dissolve and degrade the stoma appliance itself.

[0019] Potato protein, as used herein, refers to proteins obtained from potato tubers (Solanum tuberosum). Potato proteins are extracted from potatoes and fractionated into various molecular weight fractions. The low molecular weight fractions contain potato proteins that can interact with enzymes and reduce their activity. Potato proteins can interact with enzymes, particularly trypsin, an enzyme that is often present in the stoma output, where it can cause skin damage and lead to complications such as redness, itching, and discomfort.

[0020] The skin care composition may comprise 15-60% by weight of potato protein, such as 20-50%, for example 25-40% or 25-35% or 25-45% by weight, for example 30-45% by weight. In an embodiment, potato protein accounts for at least 40% by weight of the total amount of particles in the composition (potato protein, clay and other solids combined).

[0021] Potato proteins exhibit little or no swelling when wet and therefore do not cause swelling / expansion of the skin care composition.

[0022] As used herein, the term "solid" refers to one or more ingredients having solid properties, such as fillers, stabilizers, etc. Skin care compositions contain at least one solid. Solids can help adjust the texture and stability of the composition, as well as affect the composition's ability to erode upon contact with stoma output. In embodiments, the solid comprises a clay. Clays are particulate phyllosilicate materials. Clays may contain charged alumosilicate layers and interlayer cations. Clays may be present in an amount of 20-80% by weight of the composition, such as 20-65% by weight, such as 20-50% by weight, such as 20-40% by weight, or 25-70% by weight, such as 25-70% by weight, preferably 25-60% by weight, more preferably 30-50% by weight. The clay is preferably a smectite clay, preferably selected from the group consisting of montmorillonite, beidellite, nontronite, saponite, and hectorite. The clay may be a hectorite-type smectite clay, preferably Laponite, suitably having CAS number 53320-86-8, CAS number 64060-48-6, or a combination thereof. In chemical terms, the clay is suitably a lithium magnesium sodium silicate or sodium magnesium fluorosilicate.

[0023] Laponite RD belongs to the BYK family of International Cosmetic Ingredient Nomenclature (INCI) names of lithium magnesium sodium silicates, which also includes Laponite XLG and D. The empirical formula of Laponite RD is Na + 0.7 [(Si8Mg 5.5 Li 0.3 )O 20 (OH)4] -0.7 is.

[0024] Laponite XL21 belongs to the INCI family of sodium magnesium fluorosilicates (CAS 64060-48-6). This material contains hydroxyl groups (OH - ) plus fluorine (F -The empirical formula of Laponite XL21 is Na + 0.7 [(Si8Mg 5.5 Li 0.3 )O 20 (OH) 2.5 F 1.5 ] -0.7 is.

[0025] In embodiments, the solids include potato starch, talc, kaolin, florisil, calcium alginate, fumed silica, calcium carbonate, sodium bicarbonate, baking powder, citric acid, gelatin, blanose, microfibers, polymers such as polyacrylates, PVP, PVOH, PVA, polyolefins and copolymers, hi embodiments, the composition comprises 20-80% by weight of potato starch, e.g., 25-60% by weight, or 20-30% by weight, or 40-50% by weight.

[0026] In embodiments, the combined amount of potato protein, clay, and other solids comprises 50-75% by weight of the composition, for example 55-70% by weight. If the total amount of particles is too low, the texture of the composition may be too fluid. If the amount of particles is too high, the texture may be too hard and inflexible.

[0027] In embodiments, the combination of potato protein and clay can achieve low expansion when wetted. This may be due in part to the low expansion of potato protein, but may also be due to the effect that the swelling of the clay is likely delayed in the presence of potato protein, as liquids may penetrate the composition more slowly. Similarly, other solids used in the composition also have low expansion when wetted. If the skin care composition is located near the stoma, the large expansion of the composition upon exposure to stoma output may cause undesirable pressure on the stoma.

[0028] Some solids, such as clay, may also be able to interact with harmful components from the stoma output. Such materials may have the inherent ability to interact with a wide range of compounds and may complement the effect of potato proteins, which more specifically address the enzymes of the stoma output.

[0029] By combining potato protein and clay in a skin care composition, a composition capable of interacting with a wide range of harmful substances from the stoma output is achieved. The clay may be capable of interacting with a wide range of harmful substances, while the potato protein is capable of interacting with enzymes. Enzymes such as trypsin from the stoma output can be quite aggressive when in contact with peristomal skin and can cause skin damage. Furthermore, if clay is used alone to reduce enzyme activity, the presence of the clay can cause significant swelling of the skin care composition. By replacing at least a portion of the clay with potato protein, a composition is provided that has low swelling, good texture, and can reduce the activity of harmful substances in the output.

[0030] In embodiments, the skin care composition comprises a solid having stabilizing properties. The stabilizer may prevent syneresis by stabilizing the texture of the skin care composition.

[0031] In embodiments, the solid comprises a compound that promotes easier and / or faster erosion of the skin care composition. Such a compound may allow for faster or more effective erosion of the potato proteins and clay from the skin care composition. An example of such a compound may be baking powder.

[0032] The skin care composition further comprises at least one binder, which may be a polar and / or non-polar polymer or copolymer and may be present in an amount of 20 to 70% by weight, such as 20 to 50% by weight, for example 25 to 40% by weight.

[0033] In an embodiment, the skin care composition comprises first and second binders that may act in concert to ensure the appropriate texture of the skin care composition and, at the same time, the interaction of the potato protein and the clay when in contact with the stoma output. The skin care composition may be in the form of a powder, a dough or a fluid, depending on the ratio of solids and binders.

[0034] In embodiments, the polar binder comprises a compound that is fluid at room temperature, hi embodiments, the polar binder comprises glycerol, polyglycerol, a polymer or copolymer of ethylene glycol and / or a polymer or copolymer of propylene glycol.

[0035] Including an amount of polar binder in the skin care composition can prevent syneresis of the skin care composition. In an embodiment, the polar binder is present in the skin care composition in an amount of 10 to 70 wt %, for example, 10 to 50 wt %, for example, 20 to 40 wt %.

[0036] In embodiments, the skin care composition includes a non-polar binder that is fluid at room temperature. The non-polar binder may be a polyolefin, such as polybutene, hydrogenated polybutene, liquid isoprene, polyα-olefin, or a wax. The non-polar binder may be present in an amount of 10 to 70% by weight of the composition, such as 20 to 50% by weight, for example, 20 to 40% by weight.

[0037] In embodiments, the composition includes a first non-polar binder having a different molecular weight than the second binder. Having a low molecular weight polymer along with a high molecular weight polymer can prevent syneresis of the skin care composition.

[0038] In one particular embodiment, the skin care composition comprises the following composition: a. 10-50% by weight of potato protein; b. 25 to 50 wt. % of a non-polar binder; c. 35 to 50 wt.% solids Includes; wherein said potato protein, non-polar binder are as defined above. In another particular embodiment, the skin care composition comprises the following composition: a. 20-40% by weight of potato protein; b. 25 to 45 weight percent solids in the form of clay; c. 25 to 40 wt. % of a first non-polar binder; d. 1 to 5 wt. % of a second non-polar binder; Includes; wherein said potato protein, clay, first binder and second binder are as defined above.

[0039] An embodiment provides a skin care composition comprising: 25-45% by weight of potato protein; a first binder comprising a polar or non-polar polymer or copolymer in an amount of 20-50% by weight; and 20-40% by weight of a solid comprising a clay.

[0040] An embodiment provides a skin care composition comprising potato protein and solids in a combined amount of 50-75% by weight in the composition, the composition comprising: 25-45% by weight of potato protein; a first binder comprising a polar or non-polar polymer or copolymer in an amount of 20-50% by weight; and 20-40% by weight of solids comprising clay.

[0041] The skin care composition may have one of the following compositions a-f listed in Table 1.

[0042] [Table 1]

[0043] Also provided is the use of the skin care compositions described herein in the peristomal environment. The skin care compositions are used to reduce enzyme activity, particularly trypsin activity. As described, potato protein and clay particles can be washed out of the skin care composition and interact with the enzymes.

[0044] A method for reducing enzymatic activity in output is provided, comprising providing a skin care composition as defined herein and applying the skin care composition to peristomal skin and / or a stoma wafer, whereby the skin care composition reduces enzymatic activity in stoma output that may come into contact with the composition.

[0045] A method for preventing skin damage and / or maceration is provided, comprising providing a skin care composition as defined herein and applying the skin care composition to peristomal skin and / or a stoma wafer, such that the skin care composition reduces enzymatic activity in any stoma output that may come into contact with the peristomal skin, thereby reducing the invasiveness of the output and preventing skin damage.

[0046] Also provided are ostomy appliances comprising the skin care compositions described herein, as well as ostomy appliance faceplates comprising the skin care compositions described herein. [Example]

[0047] The skin care compositions disclosed in Table 2 below are mixed. The compositions have a dough-like texture, low expansion / swelling, no signs of syneresis, and good cohesion. When exposed to stoma output, a reduction in enzyme activity in the output is achieved.

[0048] [Table 2]

Claims

1. 1. A skin care composition comprising at least 15% by weight of potato protein, a first binder comprising a polar or non-polar polymer or copolymer in an amount of 25-50% by weight, and 20-60% by weight of solids comprising clay, wherein the total content of potato protein, clay and other solids is in the range of 50-75% by weight.

2. 2. The skin care composition of claim 1, wherein the composition comprises 15 to 60% by weight of potato protein, such as 20 to 50%, for example 25 to 40% or 25 to 35% by weight.

3. The skin care composition according to claim 1 or 2, wherein the composition comprises at least one binder in an amount of 20 to 40% by weight of the composition.

4. The skin care composition according to any one of claims 1 to 3, wherein the composition comprises a second binder having a different molecular weight than the first binder.

5. The skin care composition according to any one of claims 1 to 4, wherein the clay is a smectite clay, preferably selected from the group consisting of montmorillonite, beidellite, nontronite, saponite and hectorite.

6. 6. The skin care composition according to any one of claims 1 to 5, wherein the clay is a hectorite-type smectite clay, preferably Laponite, more preferably those having CAS No. 53320-86-8, CAS No. 64060-48-6 or combinations thereof, preferably Laponite RD or Laponite XL21.

7. The skin care composition according to any one of claims 1 to 6, wherein the solid comprises potato starch or talc.

8. Use of the skin care composition according to any one of claims 1 to 7 in the peristomal environment.

9. 9. Use according to claim 8 for reducing enzyme activity, in particular trypsin activity.

10. A stoma appliance comprising the skin care composition according to any one of claims 1 to 7.

11. A base plate for a stoma appliance, comprising the skin care composition according to any one of claims 1 to 7.

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