Anti-pro / latent-myostatin antibodies and uses thereof
Antibodies targeting pro/latent myostatin inhibit its activation, addressing the challenge of muscle atrophy and promoting muscle growth, enhancing muscle mass and strength in therapeutic applications.
JP2026035721APending Publication Date: 2026-03-04SCHOLAR ROCK INC
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Patent Information
- Authority / Receiving Office
- JP · JP
- Patent Type
- Applications
- Current Assignee / Owner
- Filing Date
- 2025-11-27
- Publication Date
- 2026-03-04
AI Technical Summary
Technical Problem
Current technologies lack effective methods to inhibit myostatin signaling, which negatively regulates muscle mass, leading to muscle atrophy and weakness in various conditions.
Method used
Development of antibodies that specifically bind to pro/latent myostatin, inhibiting its activation by proteases and preventing muscle atrophy, thereby promoting muscle growth and strength.
Benefits of technology
The antibodies effectively increase muscle mass and strength by blocking myostatin activation, offering therapeutic benefits for conditions such as muscle atrophy, sarcopenia, and various myopathies.
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Smart Images
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Abstract
To provide antibodies that specifically bind to promyostatin and / or latent myostatin, and uses thereof.SOLUTION: The antibody binds to myostatin and can prevent cleavage of myostatin by a proprotein convertase and / or a tolloid protease. Preventing cleavage of pro-myostatin or latent myostatin may prevent myostatin activation. The antibodies may be pH-sensitive in their affinity for the antigen, and such pH-sensitive antibodies may be effective in eliminating the antigen from the serum. The antibody can be a sweeping antibody that can efficiently clear antigen (e.g., pro-myostatin and / or latent myostatin) from the serum.SELECTED DRAWING: None
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