Pore-minimizing agents, cosmetics, and topical skin preparations

Abstract

To provide a pore-enhancing agent. [Solution] A pore-minimizing agent characterized by containing sea mud extract and rosehip extract.

Description

Technical Field

[0001] The present disclosure relates to a pore visibility improver, a cosmetic, and a topical skin preparation.

Background Art

[0002] In recent years, many women have complained of skin problems related to the visibility of pores, and there is a demand for topical skin preparations that improve this. The visibility of pores is caused by darkening of the pores and the pores opening up, and is considered to be caused by various troubles such as sagging of the skin, decrease in elasticity, dryness, decrease in barrier function, and incomplete keratinization due to excessive secretion of sebum, dryness, aging, etc., which lead to enlargement and deformation of the pores and pigmentation around the pores. In order to make pores less visible, in addition to cleaning pores and tightening with a astringent lotion, various approaches using plant extracts and vitamins that address the causes of pore visibility have been proposed, but the effects are not sufficient.

[0003] Patent Document 1 describes a cosmetic characterized by containing (A) sea mud and (B) charcoal, particularly a cosmetic cleanser or pack having excellent usability.

[0004] Patent Document 2 discloses a pore visibility inhibitor characterized by containing an extract of Polygonatum odoratum as an active ingredient.

Prior Art Documents

Patent Documents

[0005]

Patent Document 1

Patent Document 2

Summary of the Invention

Problems to be Solved by the Invention

[0006] Patent Document 1 uses sea mud in the form of a dried powder. While it describes the effectiveness of sea mud as a cleansing agent, it does not describe its effectiveness in reducing the appearance of pores.

[0007] One of the problems that this disclosure aims to solve is to provide a pore-minimizing agent and a topical skin preparation that are excellent in terms of stability and usability. [Means for solving the problem]

[0008] This disclosure includes, for example, the following subjects:

[0009] Section 1. A pore-minimizing agent characterized by containing sea mud extract and rosehip extract.

[0010] Section 2. The pore-concealing agent according to item 1, characterized by containing 0.001 to 5000 parts by mass of sea mud extract per 1 part by mass of rosehip extract.

[0011] Section 3. A cosmetic product for improving the appearance of pores, characterized by containing sea mud extract and rosehip extract.

[0012] Section 4. A topical skin preparation characterized by containing sea mud extract and rosehip extract.

[0013] Section 5. The topical skin preparation according to item 4, characterized in that it contains 0.001 to 5000 parts by mass of sea mud extract per 1 part by mass of rosehip extract.

[0014] Section 6. A topical skin preparation according to item 4, characterized by containing 0.001 to 5000 parts by mass of sea mud extract per 1 part by mass of rosehip extract.

[0015] Section 7. The external preparation for skin according to item 4, which is a sebum production inhibitor characterized by containing 0.001 to 5000 parts by mass of sea mud extract with respect to 1 part by mass of the extract of Polygonatum odoratum.

[0016] Item 8. The external preparation for skin according to item 4, which is an antioxidant characterized by containing 0.5 to 5000 parts by mass of sea mud extract with respect to 1 part by mass of the extract of Polygonatum odoratum.

[0017] Item 9. Use of sea mud extract and Polygonatum odoratum for producing a pore visibility improver, a cosmetic for improving pore visibility, or an external preparation for skin.

[0018] Item 10. The use according to item 9, wherein the pore visibility improver, the cosmetic for improving pore visibility or the external preparation for skin contains 0.001 to 5000 parts by mass of sea mud extract with respect to 1 part by mass of the extract of Polygonatum odoratum.

Effects of the Invention

[0019] According to the present disclosure, it is possible to provide a pore visibility improver, a cosmetic and an external preparation for skin that are excellent in stability and usability.

Brief Description of the Drawings

[0020] [Figure 1] Photograph of the state after mixing the bottle containing the preparation of Example 1 (right), the bottle containing the preparation of Comparative Example 2 (left), and the bottle containing the preparation of Comparative Example 2 (center) (center). [Figure 2] Photographs of each bottle after one month in the same order of the preparation as in FIG. 1. [Figure 3] Graph regarding the antioxidant (DPPH radical scavenging) action of each of the preparations containing sea mud extract alone, Polygonatum odoratum extract alone, and both sea mud extract and Polygonatum odoratum extract at five mixing ratios. ** P<0.01, * P<0.05. [Figure 4]Graphs showing the effect of sea mud extract alone (Comparative Example 3), rosehip extract alone (Comparative Example 4), and formulations containing both sea mud extract and rosehip extract in seven different formulation ratios (Examples 1, 2, 3, 4, 7, 8, and 9) on improving skin turnover (restoration of L value by tanning agents). ** P<0.01, * P<0.05. [Modes for carrying out the invention]

[0021] In this specification, "contains" is a concept that also includes "substantially consists only of" and "consists only of."

[0022] In the numerical ranges described stepwise in this specification, the upper or lower limit of a numerical range in one step can be arbitrarily combined with the upper or lower limit of a numerical range in another step. Furthermore, in the numerical ranges described in this specification, the upper or lower limit of a numerical range may be replaced with values ​​shown in the examples or values ​​that can be uniquely derived from the examples. Moreover, in this specification, a range connected by two numerical values ​​means a range that includes those two numerical values ​​as the lower and upper limits.

[0023] The embodiments included in this disclosure will be described further below. The embodiments described below are examples of typical embodiments of this disclosure and do not limit the scope of the invention.

[0024] This disclosure provides a pore-minimizing agent characterized by containing sea mud extract and rosehip extract.

[0025] The inventors developed a sea mud extract from sea mud, a raw material for cosmetic ingredients, using a unique manufacturing method. They found that a composition containing a combination of sea mud extract and rosehip extract exhibits superior stability and usability compared to a composition containing a combination of sea mud powder and rosehip extract, and improves the appearance of visible pores. More specifically, it showed remarkable synergistic effectiveness against oxidation, excessive sebum secretion, and keratin plug formation, which are factors contributing to visible pores, thereby improving the appearance of visible pores. Compositions containing sea mud extract and rosehip extract show remarkable effectiveness against at least one of the factors contributing to visible pores, namely oxidation, excessive sebum secretion, and / or keratin plug formation, thereby improving the appearance of visible pores.

[0026] In this specification, "improvement of visible pores" means at least one of the following: making pores less noticeable by physically reducing the volume of pores in the skin, and suppressing the visibility of pores through visual effects. This includes reducing the size of the pores themselves, improving the indentation of the skin around the pores, suppressing the formation of keratin plugs that block pores and hinder pore contraction, suppressing the appearance of pores due to shine by suppressing the production of excessive sebum, and suppressing the appearance of pores due to blackheads by suppressing the oxidation of sebum.

[0027] Eijitsu refers to the dried mature fruit of the wild rose (scientific name: Rosa multiflora), a plant of the Rosaceae family. Wild rose is a deciduous shrub distributed from southwestern Hokkaido to Kyushu and the Korean Peninsula, and eijitsu, which is the dried mature fruit of wild rose, can be easily obtained from these regions. The eijitsu extract used in the cosmetic composition of the present invention can be obtained by drying the extraction raw material, then crushing it as is or using a crushing machine, and subjecting it to extraction with an extraction solvent. The extraction raw materials of the above plants may be subjected to extraction treatment individually, or two or more extraction raw materials may be combined for extraction treatment. Either a polar solvent or a non-polar solvent may be used as the extraction solvent. When using polar solvents, examples include water and hydrophilic organic solvents. Examples of aqueous organic solvents include lower aliphatic alcohols with 1 to 5 carbon atoms such as methanol, ethanol, propyl alcohol, and isopropyl alcohol; polyhydric alcohols with 2 to 5 carbon atoms such as 1,3-butylene glycol, propylene glycol, and glycerin; and lower aliphatic ketones with 3 to 6 carbon atoms such as acetone and methyl ethyl ketone. The rosehip extract obtained in this way contains flavonoids, and it is presumed that these active ingredients exert the effects of the present invention, but the reasons for making the rosehip extract essential in the present invention are not limited to these. Commercially available rosehip extracts can also be used. Examples of commercially available products include Rosehip Extract-R, Rosehip Extract BG-R, Rosehip Extract BG-01, and Clear Rose Fruit (all from Maruzen Pharmaceutical Co., Ltd.).

[0028] In this specification, "sea mud" refers to marine-derived natural inorganic material containing buried marine plants and animals, and humus containing various minerals including silicon, aluminum, calcium, iron, magnesium, sulfur, and phosphorus. Marine plants and animals include shells, various fish nekton, plankton, algae, seagrass, and other organisms. Sea mud can include material collected from above ground due to crustal movements, as well as material collected directly from deep within the seabed. Sea mud also includes kucha and glacial mud. Collected sea mud can be used after being dried and crushed as needed. Sea mud can be collected from sea mud mining sites in Japan or overseas, or commercially available products can be used. Examples of commercially available products include Milonecton, Milonecton R (both from Dainippon Kasei Co., Ltd.), Marine Silt FP, Marine Silt FP-S (both from Encore An Co., Ltd.), and Glacial Oceanic Clay Powder (Ironwood Clay Co. Inc.).

[0029] In this specification, "sea mud extract" refers to an extract obtained by extracting solvent-soluble components, particularly cosmetic components, from "sea mud" which contains insoluble components that do not dissolve in solvents commonly used in topical skin preparations. Sea mud extract has had insoluble solids such as aluminum oxide removed, making it easier to incorporate into dosage forms, which was difficult with sea mud.

[0030] The sea mud extract preferably contains 0.1 to 100 mg / L of sodium, 0.1 to 50 mg / L of magnesium, 0.1 to 100 mg / L of potassium, and 1 to 1000 mg / L of calcium.

[0031] Furthermore, in the sea mud extract, the amount of silicon is preferably 10 mg / L or less, and the amount of aluminum is preferably 10 mg / L or less.

[0032] The solid content concentration of the sea mud extract is preferably 0.05 to 0.5% by mass. Note that the solid content concentration refers to the ratio of solids to liquids in the sea mud extract.

[0033] The sea mud extract used in this invention is obtained by extracting the sea mud with an extraction solvent using an extraction means, and contains components that have an effect on improving the appearance of pores. Furthermore, it is preferable to filter the sea mud to remove unwanted substances and disinfect it. The sea mud extract thus obtained may be diluted, concentrated, and / or dried as needed, or separated and / or purified to remove impurities, etc. The form of the sea mud extract is not particularly limited, and examples include liquid, semi-solid, or solid. Specifically, examples include solutions, suspensions, concentrates, emulsions, slurries, powders, granules, and solids.

[0034] One example of a suitable method for producing a sea mud extract is to add an extraction solvent to sea mud, mix and stir, and then extract and separate the active ingredients to obtain the sea mud extract.

[0035] Extraction methods include solid-liquid extraction, liquid-liquid extraction, immersion, decoction, leaching, reflux extraction, supercritical fluid extraction, ultrasonic extraction, microwave extraction, and mixing and stirring. These may be combined as appropriate. Separation methods include filtration and centrifugation, which may be used individually or in combination. Filtration methods include natural filtration, reduced-pressure filtration, and pressure filtration. In this case, filter media such as cellulose filters, glass fiber filters, and membrane filters are used, and filter aids such as Celite, gravel, and activated carbon are used as needed. The pore size is not particularly limited, but for example, 0.1 to 1 μm is preferred. These may be combined as appropriate. Furthermore, there are no particular limitations on whether or not drying or pre-treatment of the sea mud is performed prior to extraction, or the method thereof.

[0036] The extraction solvent is not particularly limited, and either polar or nonpolar solvents may be used. Examples of extraction solvents include water (water containing minerals such as hot spring water or deep-sea water, or purified water); linear, branched, or cyclic alcohols; ketones such as acetone and methyl ethyl ketone; esters such as methyl acetate and ethyl acetate; linear and cyclic ethers such as tetrahydrofuran and diethyl ether; polyethers such as polyethylene glycol; hydrocarbons such as squalane, hexane, cyclohexane, and petroleum ether; aromatic hydrocarbons such as toluene; halogenated hydrocarbons such as dichloromethane, chloroform, and dichloroethane; and supercritical carbon dioxide. These may be used individually or as mixed solvents in combination of two or more. Furthermore, water-soluble organic solvents are preferred.

[0037] The extraction solvent is preferably one or more selected from the group consisting of water, alcohols, ketones, and supercritical carbon dioxide. Of these, one or more selected from the group consisting of water and alcohols are preferred, for example, water, alcohols, or a mixture of water and alcohols.

[0038] Here, the alcohols may be monohydric or polyhydric alcohols. Examples of monohydric alcohols include methanol, ethanol, and propanol, while examples of polyhydric alcohols include ethylene glycol, propylene glycol, 1,3-butylene glycol, 1,2-pentanediol, glycerin, and dipropylene glycol. Among the alcohols, lower alcohols having 1 to 5 carbon atoms, such as ethanol and 1,3-butylene glycol, are preferred, of which lower monohydric alcohols are preferred, and of which ethanol is even more preferred.

[0039] Of these, water and mixed solutions of water and alcohol are particularly preferred. Specifically, aqueous solutions containing 0 to 90% by volume of alcohols are preferred, preferably 0 to 70% by volume, more preferably 0 to 50% by volume, and even more preferably 0 to 20% by volume.

[0040] The amount of solvent used is not particularly limited, but for example, 100 to 1000 L is preferred for 100 kg of sea mud (in a dry state), and 200 to 1000 L is more preferred, as this is preferable in terms of extraction efficiency of sea mud components and work efficiency.

[0041] The extraction period is not particularly limited, but is preferably 1 hour to 3 years, and more preferably 1 hour to 90 days.

[0042] The mixing and stirring of the sea mud and the extraction solvent at this time is not particularly limited, but for example, it can be done for about 0.5 to 48 hours. This allows the sea mud and the extraction solvent to come into contact, making it easier to extract the active ingredients. Furthermore, the mixing and stirring may be done continuously or discontinuously. For example, after mixing and stirring, it may be mixed and stirred again for a certain period of time, or mixed and stirred for a certain period of time and then left to stand, or left to mature.

[0043] The extraction temperature is not particularly limited, but is, for example, around 0 to 100°C. A heating temperature of 50 to 100°C is preferable for efficiently extracting components in a short period of time.

[0044] The drying methods include sun drying, natural drying, wind drying, heat drying, and freeze drying, and are suitable as long as the drying method does not cause thermal denaturation of the sea mud. At this time, it is desirable to dry the sea mud to the extent that it can be finely pulverized, as pulverization improves the extraction efficiency of the sea mud, making it preferable. The sea mud extract is preferably one from which insoluble substances and other impurities have been removed by filtration.

[0045] The sea mud extract preferably contains 100 mg / L or less of humic substances when converted to a 0.5% by mass aqueous solution with a solid content concentration. Here, humic substances (humic substances) refer to high-molecular-weight substances that are produced when, for example, plant components decompose and condense in the soil. Here, the humic substance value is the value obtained when measured by the method described in the humic substance measurement method of the mineral spring testing method.

[0046] The pH of the sea mud extract is preferably in the neutral range of pH 4 to 10, more preferably pH 6 to 9, in terms of pharmacological activity and stability. In this case, the solid content of the sea mud extract may be 0.1 to 1% by mass aqueous solution and the pH may be adjusted as appropriate with a pH adjuster at 20°C.

[0047] The amount of rosehip extract in the pore-minimizing agent is not particularly limited, but is preferably 0.0001 to 99.9999% by mass. In one embodiment, the amount of rosehip extract in the pore-minimizing agent is 0.001 to 25% by mass. In another embodiment, the amount of rosehip extract in the pore-minimizing agent is 0.01 to 10% by mass.

[0048] The amount of sea mud extract in the pore-minimizing agent is not particularly limited, but is preferably 0.0001 to 99.9999% by mass. In one embodiment, the amount of sea mud extract in the pore-minimizing agent is 0.001 to 25% by mass. In another embodiment, the amount of sea mud extract in the pore-minimizing agent is 0.01 to 10% by mass.

[0049] The ratio of rosehip extract to sea mud extract in the pore-minimizing agent is not particularly limited, but it is preferable that the ratio is 0.001 to 5000 parts by mass of sea mud extract per 1 part by mass of rosehip extract, and more preferably 0.001 to 1000 parts by mass. Such a ratio provides an excellent effect in improving the appearance of pores. In one embodiment, the ratio is 0.01 to 1000 parts by mass of sea mud extract per 1 part by mass of rosehip extract. In another embodiment, the ratio is 0.01 to 100 parts by mass of sea mud extract per 1 part by mass of rosehip extract.

[0050] The total ratio of rosehip extract and sea mud extract in the pore-minimizing agent is, for example, 0.001 to 100% by mass. In one embodiment, the total ratio of rosehip extract and sea mud extract in the pore-minimizing agent may be 0.01 to 100% by mass. In another embodiment, the total ratio of rosehip extract and sea mud extract in the pore-minimizing agent may be 0.01 to 50% by mass. In yet another embodiment, the total ratio of rosehip extract and sea mud extract in the pore-minimizing agent may be 0.01 to 10% by mass.

[0051] Furthermore, pore-minimizing agents may contain ingredients other than rosehip extract and sea mud extract.

[0052] This disclosure provides a cosmetic composition for improving the appearance of visible pores, characterized by containing sea mud extract and rosehip extract. Such a cosmetic composition for improving the appearance of visible pores includes a cosmetic composition for improving the appearance of visible pores containing the above-mentioned pore-improving agent, and can be provided by blending the above-mentioned pore-improving agent with a cosmetic composition containing ingredients other than sea mud extract and rosehip extract.

[0053] The amount of rosehip extract in the pore-minimizing cosmetic is not particularly limited, but is preferably 0.0001 to 99.9999% by mass. In one embodiment, the amount of rosehip extract in the pore-minimizing cosmetic is 0.001 to 25% by mass. In another embodiment, the amount of rosehip extract in the pore-minimizing cosmetic is 0.01 to 10% by mass.

[0054] The amount of sea mud extract in the pore-minimizing cosmetic is not particularly limited, but is preferably 0.0001 to 99.9999% by mass. In one embodiment, the amount of sea mud extract in the pore-minimizing cosmetic is 0.001 to 25% by mass. In another embodiment, the amount of sea mud extract in the pore-minimizing cosmetic is 0.01 to 10% by mass.

[0055] The ratio of rosehip extract to sea mud extract in the cosmetic for improving the appearance of pores is not particularly limited, but it is preferable that the amount of sea mud extract is 0.001 to 1000 parts by mass per 1 part by mass of rosehip extract, and more preferably 0.001 to 1000 parts by mass. This ratio provides an excellent effect in improving the appearance of pores.

[0056] Cosmetics may be used in various forms, such as lotions, creams, toners, serums, masks, cleansers, makeup products, hair growth products, shampoos, and conditioners.

[0057] This disclosure provides a topical skin preparation characterized by containing sea mud extract and rosehip extract. Such a topical skin preparation is useful for improving the appearance of enlarged pores. Such a topical skin preparation includes a topical skin preparation containing the above-mentioned pore-improving agent, and can be provided by incorporating the above-mentioned pore-improving agent into a composition for manufacturing a topical skin preparation that contains ingredients other than sea mud extract and rosehip extract.

[0058] The amount of rosehip extract in the topical skin preparation is not particularly limited, but is preferably 0.0001 to 50% by mass. In one embodiment, the amount of rosehip extract in the topical skin preparation is 0.001 to 25% by mass. In another embodiment, the amount of rosehip extract in the topical skin preparation is 0.01 to 10% by mass.

[0059] The amount of sea mud extract in the topical skin preparation is not particularly limited, but is preferably 0.0001 to 50% by mass. In one embodiment, the amount of sea mud extract in the topical skin preparation is 0.001 to 25% by mass. In another embodiment, the amount of sea mud extract in the topical skin preparation is 0.01 to 10% by mass.

[0060] The ratio of rosehip extract to sea mud extract in the topical skin preparation is not particularly limited, but it is preferably 0.001 to 5000 parts by mass of sea mud extract per 1 part by mass of rosehip extract, and more preferably 0.001 to 1000 parts by mass. This ratio provides an excellent effect in improving the appearance of pores. In one embodiment, the amount of sea mud extract in the topical skin preparation is 0.01 to 1000 parts by mass per 1 part by mass of rosehip extract. In another embodiment, the amount of sea mud extract in the topical skin preparation is 0.01 to 100 parts by mass per 1 part by mass of rosehip extract.

[0061] Topical skin preparations may take the form of dispersions, ointments, liquids, aerosols, patches, poultices, liniments, etc., and include quasi-drugs and pharmaceuticals.

[0062] Furthermore, each of the cosmetics and topical skin preparations may contain, as optional ingredients, various components commonly used in cosmetics and / or topical skin preparations, such as water, alcohol, oils, surfactants, thickeners, powders, chelating agents, pH adjusters, moisturizers, whitening agents, anti-inflammatory agents, cell activators, and other various pharmacological agents, as well as extracts derived from plants, animals, and microorganisms (excluding sea mud extracts), fragrances, etc., to the extent that they do not impair the effects of the present invention.

[0063] The amount of water in each of the pore-minimizing agent, pore-minimizing cosmetic, and topical skin preparation is not particularly limited, but may be, for example, 0 to 98% by mass. In one embodiment, the amount of water in each of the pore-minimizing agent, pore-minimizing cosmetic, and topical skin preparation is 50% by mass or more, 60% by mass or more, 70% by mass or more, or 80% by mass or more.

[0064] This disclosure provides a keratin plug formation inhibitor characterized by containing sea mud extract and rosehip extract.

[0065] The combination of sea mud extract and rosehip extract described herein may also act to suppress the formation of keratin plugs.

[0066] The ratio of rosehip extract to sea mud extract in the keratin plug inhibitor is not particularly limited, but a ratio of 0.001 to 5000 parts by mass, more preferably 0.001 to 1000 parts by mass, of sea mud extract per 1 part by mass of rosehip extract is excellent in inhibiting keratin plug formation. In one embodiment, the keratin plug inhibitor contains 0.01 to 1000 parts by mass of sea mud extract per 1 part by mass of rosehip extract. In another embodiment, the keratin plug inhibitor contains 0.01 to 100 parts by mass of sea mud extract per 1 part by mass of rosehip extract.

[0067] The keratin plug formation inhibitor containing the above-mentioned sea mud extract and rosehip extract can also act to suppress keratin plug formation, and therefore can be considered as one embodiment of the above-mentioned pore-visibility improving agent or pore-visibility improving cosmetic. Furthermore, such a keratin plug formation inhibitor may be any of the above-mentioned topical skin preparations.

[0068] This disclosure provides a sebum production inhibitor characterized by containing sea mud extract and rosehip extract.

[0069] The pore-minimizing agent containing sea mud extract and rosehip extract of the present invention may also act as a sebum production inhibitor and suppress the formation of keratin plugs.

[0070] The ratio of rosehip extract to sea mud extract in the topical skin preparation is not particularly limited, but a ratio of 0.001 to 5000 parts by mass, more preferably 0.001 to 1000 parts by mass, of sea mud extract per 1 part by mass of rosehip extract is excellent in suppressing sebum production. In one embodiment, the ratio of sea mud extract to rosehip extract in the topical skin preparation is 0.01 to 1000 parts by mass per 1 part by mass of rosehip extract. In another embodiment, the ratio of sea mud extract to rosehip extract in the topical skin preparation is 0.01 to 100 parts by mass per 1 part by mass of rosehip extract.

[0071] The sebum production inhibitor containing the above-mentioned sea mud extract and rosehip extract can also act to suppress sebum production, and therefore can be considered as one embodiment of the above-mentioned pore-concealing agent or pore-concealing cosmetic. Furthermore, such a sebum production inhibitor may be any of the above-mentioned topical skin preparations.

[0072] This disclosure provides an antioxidant characterized by containing sea mud extract and rosehip extract.

[0073] The pore-minimizing agent containing sea mud extract and rosehip extract of the present invention may also act as an antioxidant.

[0074] While the ratio of rosehip extract to sea mud extract in the antioxidant is not particularly limited, the antioxidant effect is superior when the amount of sea mud extract is 0.0001 to 5000 parts by mass, preferably 0.5 to 5000 parts by mass, and more preferably 50 to 4545 parts by mass, per 1 part by mass of rosehip extract.

[0075] The antioxidant containing the above-mentioned sea mud extract and rosehip extract may also have antioxidant properties, and can therefore be considered as one embodiment of the above-mentioned pore-minimizing agent or pore-minimizing cosmetic. Furthermore, such antioxidant may be any of the above-mentioned topical skin preparations.

[0076] This disclosure also provides the use of sea mud extract and rosehip extract for manufacturing pore-minimizing agents, pore-minimizing cosmetics, or topical skin preparations.

[0077] The respective amounts of rosehip extract and sea mud extract, as well as their respective proportions, in the pore-minimizing agent, pore-minimizing cosmetic, or topical skin preparation are as determined.

[0078] Preferably, in terms of improving the appearance of pores, the pore-minimizing agent, pore-minimizing cosmetic, or topical skin preparation contains 0.001 to 5000 parts by mass, preferably 0.001 to 1000 parts by mass, of sea mud extract per 1 part by mass of rosehip extract, and in a specific embodiment, contains 0.5 to 5000 parts by mass, more preferably 50 to 4545 parts by mass, of sea mud extract per 1 part by mass of rosehip extract.

[0079] All patent applications and disclosures cited herein are incorporated herein by reference in their entirety.

[0080] The following examples are for illustrative purposes only and are not intended to limit the technical scope of the present invention in any way. Unless otherwise specified, reagents are obtained or prepared from commercially available sources or according to methods commonly used in the art or procedures described in prior art. [Examples]

[0081] The following are examples and embodiments to illustrate the present invention in detail, but the present invention is not limited to these.

[0082] Test Example 1. Production of sea mud extract Sea mud collected from soil near Tanagura, Fukushima Prefecture, was dried and then finely ground. 5 kg of this ground material and 50 liters of purified water were heated and stirred at 40-90 degrees Celsius for 3 hours to obtain an extract. This extract was filtered to remove insoluble solids, resulting in the sea mud extract. The pH of the sea mud extract at room temperature (20°C) was 7.3. This aqueous solution was used as the sea mud extract for Production Example 1.

[0083] Test Example 2. Preparation of various formulations and evaluation of their appearance and stability. (1) Preparation of various formulations Using the formulations listed in Table 1, the formulation of Example 1 was manufactured by combining the sea mud extract (also referred to as sea mud extract) from Test Example 1 and Clear Rose Fruit (rose fruit extract / Maruzen Pharmaceutical Co., Ltd.). The units for each component in the table are mass.

[0084] Examples 2 to 9 are formulations obtained by changing the ratio of sea mud extract and rosehip extract compared to Example 1.

[0085] Comparative Example 1 is a formulation that does not contain either sea mud extract or rosehip extract.

[0086] Comparative Example 2 is a formulation that contains a dispersion of 0.3 g of sea mud powder dispersed in 2.7 g of water, instead of the sea mud extract used in Example 1.

[0087] Comparative Example 3 is a formulation that contains rosehip extract instead of sea mud extract in Example 1, and Comparative Example 4 is a formulation that contains sea mud extract instead of rosehip extract in Example 1.

[0088] (2) Evaluation of appearance and stability Each formulation was placed in a bottle. Immediately after preparation, the appearance of each formulation was clear and yellow in the case of the formulation of Example 1, which contained sea mud extract and rosehip extract (Figure 1, right). In the case of the formulation of Comparative Example 2, which contained sea mud powder and rosehip extract, the sea mud powder settled and precipitated (Figure 1, left). When the formulation of Comparative Example 1 was mixed, the formulation became cloudy (Figure 1, center).

[0089] Upon further observation of the formulations after one month, the formulation of Example 1 showed almost no change in appearance (Figure 2, right). The formulation of Comparative Example 2 changed to black (Figure 2, left). When the formulation of Comparative Example 2 was mixed, the turbidity worsened (Figure 2, center).

[0090] The complex of sea mud extract and rosehip extract offers superior appearance, stability, and long-term stability during formulation compared to the complex of sea mud powder and rosehip extract.

[0091] [Table 1]

[0092] Test Example 3. Functionality Test of Each Formulation The formulations for Example 1, Comparative Example 1, and Comparative Example 2, as described in Table 1, were prepared. Four expert panelists evaluated each product based on the following evaluation criteria regarding the feel of use when each formulation was applied to the skin: (1) feel, (2) perceived effectiveness, and (3) skin condition. The average score was then calculated.

[0093] (1) Feeling of use 1. Very bad, 2. Bad, 3. Average, 4. Good, 5. Very good.

[0094] [Table 2]

[0095] Example 1 exhibits superior usability compared to Comparative Examples 1 and 2.

[0096] (2) Feeling the effects 1. Worsening, 2. Slightly worsening, 3. No change, 4. Slightly improving, 5. Improving.

[0097] [Table 3]

[0098] In Table 3, Example 1 demonstrated superior formulation functionality compared to Comparative Examples 1 and 2, showing remarkable improvement in roughness, skin smoothness, moisturizing effect, and pore visibility.

[0099] (3) Skin condition Four expert panelists evaluated the skin condition after using the formulations of Example 1, Comparative Example 1, and Comparative Example 2, as described in Table 1, on the skin for one week, according to the following evaluation criteria.

[0100] 1. Very bad, 2. Bad, 3. Average, 4. Good, 5. Very good.

[0101] [Table 4]

[0102] Table 4 shows that, compared to Comparative Examples 1 and 2, the application of Example 1 resulted in significant improvements in the scores for skin roughness, visible pores, blackheads, visible keratin plugs, oiliness, acne / pimples, transparency, texture, makeup application, redness, blemishes / freckles, firmness / elasticity, and dryness.

[0103] Test Example 4: Coma removal effect of each formulation After removing pore plugs with a pore-plugging pack, one of the formulations from Example 1, Comparative Example 1, or Comparative Example 2 was applied continuously for one week, and the degree of change in the number of pores and porphyrin after one week was checked. There were four subjects, and the number of pores and porphyrin were measured using a VISIA skin image analysis device. TM Evolution was used. The number of pores in each subject immediately after blackhead removal was set to 100, and the number of pores one week later was expressed as a ratio to 100. The average of the pore ratios immediately after blackhead removal and one week later for four subjects was calculated.

[0104] [Table 5]

[0105] In Table 5, while the number of pores remained unchanged after one week in Comparative Examples 1 and 2, a decrease in the number of pores was observed in Example 1. Regarding porphyrin, an indicator of pore dirt and comedone formation, it was confirmed that Example 1 remained almost unchanged after one week, compared to Comparative Examples 1 and 2, which showed deterioration.

[0106] Test Example 5: Sebum secretion inhibitory effect of each formulation One of the formulations from Example 1, Comparative Example 1, or Comparative Example 2 was applied continuously for one week, and the degree of change in the amount of sebum on the cheeks before morning face washing after one week was checked. There were four subjects, and the Smart Skin Care® skin measuring device was used to measure the amount of sebum on the cheeks. The amount of sebum on each subject's cheeks at the start of the test was set to 100, and the average value of the percentage change in the amount of sebum on the cheeks before morning face washing after one week, relative to the amount of sebum at the start of the test, was calculated for the four subjects.

[0107] [Table 6]

[0108] When comparing the amount of sebum on the cheeks before washing the face in the morning, continuous use of the formulation in Example 1 for one week suppressed sebum production, and the suppression rate was higher compared to Comparative Examples 1 and 2.

[0109] Test Example 6: Effect of the mass ratio of sea mud extract and rosehip extract (1) Preparation of the preparation The test samples used were the sea mud extract from Test Example 1 and Clear Rose Fruit (obtained from Maruzen Pharmaceutical Co., Ltd.). Dilution series for the five groups A to E in Table 7 were prepared using a 50% ethanol aqueous solution (dilution series prepared for each extract individually (i,ii), and a complex (iii) created by mixing each extract so that its concentration was the same as i,ii), and these were used in the antioxidant capacity measurement test (DPPH method).

[0110] [Table 7]

[0111] (2) Evaluation test of DPPH radical scavenging effect Negative control (50% EtOH only), positive control (Trolox 160 μM), and 100 μl of each test sample were mixed with 50 μl of 200 mM MES buffer and 50 μl of 800 μM DPPH solution. After reaction at room temperature, the absorbance at 540 nm was measured. For each sample, a color correction sample solution was prepared by adding 100% ethanol solution instead of 800 μM DPPH solution, and the absorbance at 540 nm was used for correction. The DPPH radical scavenging activity was calculated using the following formula. The expected value was calculated as the sum of the measured values ​​from tests i and ii performed on each extract individually.

[0112] DPPH radical scavenging activity (%) = {(Ac-As) / (Ac-At)} × 100 Ac: Absorbance of negative control at 540 nm As: (Absorbance of DPPH ethanol sample solution at 540 nm) - (Absorbance of color correction sample solution at 540 nm) At: (Absorbance of Trolox DPPH ethanol sample solution at 540 nm) - (Absorbance of Trolox color correction sample solution at 540 nm)

[0113] In Figure 3, the white bars represent the expected additive inhibition rate of DPPH radicals expected from a formulation containing both rosehip extract and sea mud extract. This is calculated by adding the inhibition rate of rosehip extract alone and the DPPH radical scavenging activity (%) of sea mud extract alone. A higher inhibition rate of DPPH radicals reflects a higher antioxidant activity.

[0114] In all AE groups, the measured inhibition rates (black bars) of formulations containing rosehip extract and sea mud extract were higher than expected. Furthermore, in the AC group, the measured inhibition rates (black bars) of formulations containing rosehip extract and sea mud extract were significantly higher than expected. More specifically, a significant synergistic effect of 1.1 to 1.4 times compared to expected values ​​was observed in clay:rosehip extract ratios ranging from 4545:1 to 50:1, and an additive effect was observed in the range of 5:1 to 1:2.

[0115] Test Example 6: Improvement of skin cell turnover (suppression of keratin plug formation) There are various factors that cause the hyperplasia of comedones, including excessive sebum production and the accumulation of old keratin due to disrupted cell turnover, which clogs pores. Since the sebum production-inhibiting effect of the complex was confirmed in Test Example 5, we investigated the effect of the complex on cell turnover. It is known that when a tanning agent is used, the ingredient dihydroxyacetone stains the stratum corneum brown, and as the skin turns over, the stained area peels off, returning to the original skin color. The return of skin color from staining by the tanning agent was measured as an indicator of cell turnover.

[0116] The effects were compared using Examples 1, 2, 3, 4, 7, 8, and 9, and Comparative Examples 3 and 4.

[0117] A tanning agent that stains the stratum corneum brown was applied to the inner arm, and after the skin discolored, the recovery of skin color due to cell turnover after 5 days of applying the formulation was compared using the skin brightness L value with a colorimeter (Konica Minolta). The L value was set to 100 for the skin before staining with the tanning agent, and the closer the recovered value was to 100, the higher the cell turnover improvement ability. Expected values ​​were calculated from the measured values ​​of Comparative Examples 3 and 4, which contained the extract alone, and used when the extract was blended in the proportions of each example.

[0118] L-value recovery rate (%) = {L-value 5 days after application of formulation / L-value before tanning agent treatment} × 100 In all of the examples, the measured values ​​(black bars) of the recovery of the L value of the formulations containing rosehip extract and sea mud extract were significantly higher than the expected values ​​(white bars). A significant synergistic effect was confirmed, showing an increase of 0.6 to 6% compared to the expected value in the range of clay:rosehip extract ratio from 1000:1 to 1:1000.

[0119] Test Example 7 Examples of cosmetics according to formulation examples 1 to 6 of the present invention are shown below.

[0120] Example of formulation 1: Lotion A lotion with the following composition was manufactured by conventional methods. Ingredients Amount (mass%) Dipropylene glycol 8.0 Glycerin 8.0 Sorbitol 3.0 Polyquaternium-51 0.004 PEG1500 1.0 Inositol 1.0 Chelating agent (EDTA-2Na) 0.01 Preservative (appropriate amount) Rosehip Extract-R (manufactured by Maruzen Pharmaceutical Co., Ltd.) 10 Sea mud extract (Test example 1) 20 Purified water, remaining amount (total volume is 100)

[0121] Formulation example 2 Emulsion An emulsion with the following composition was prepared by a conventional method. Ingredients Amount (mass%) Polyglyceryl-10 myristate 2.1 Hydrogenated lecithin 0.6 Stearic acid 0.5 Behenyl alcohol 1.6 Cetyl palmitate 0.6 Olefin oligomer 6.0 Cetyl ethylhexanoate 6.0 Triethylhexanoin 6.0 Carbomer 0.1 Potassium hydroxide 0.05 Rosehip extract BG-R (manufactured by Maruzen Pharmaceutical Co., Ltd.) 0.5 Sea mud extract (Test example 1) 0.1 Preservative (appropriate amount) Purified water, remaining amount (total volume is 100)

[0122] Formula example 3: Cream A cream with the following composition was manufactured by conventional methods. Ingredients Amount (mass%) Hydrogenated polyisobutene 5.3 Ethylhexyl palmitate 3.0 Olive oil 5.0 Beeswax 3.0 Cetanol 3.0 Stearyl alcohol 2.0 Glyceryl stearate 2.0 PEG-75 stearate 1.0 Polysorbate 60 1.0 Glycerin 4.0 Rosehip extract BG-01 (manufactured by Maruzen Pharmaceutical Co., Ltd.) 2.0 Sea mud extract (Test Example 1) 0.2 Preservative (appropriate amount) Purified water, remaining amount (total volume is 100)

[0123] Formulation Example 4: Gel A gel with the following composition was manufactured by a conventional method. Ingredients Amount (mass%) Carbomer 0.45 (Acrylates / C10-30 Alkyl Acrylate) Crosspolymer 0.3 Glycerin 7.0 1,3-Butylene glycol 8.0 Dimethicone / Dimethiconol mixture 2.0 α-hydroxy acid mixture 0.1 Potassium hydroxide 0.07 Rosehip extract BG-R (manufactured by Maruzen Pharmaceutical Co., Ltd.) 0.5 Sea mud extract (Test example 1) 5.0 Preservative (appropriate amount) Purified water, remaining amount (total volume is 100)

[0124] Example Formulation 5: Pump Foamer Type Facial Cleanser A pump-type facial cleanser with the following composition was manufactured by conventional methods. Ingredients Amount (mass%) Sorbitol 25.0 Diglycerin 4.0 Lauryl hydroxysultaine 0.5 Sodium cocoyl glutamate 0.5 Decyl glucoside 3.0 1,3-Butylene glycol 5.0 Clear Rose Fruit (manufactured by Maruzen Pharmaceutical Co., Ltd.) 1.0 Sea mud extract (Test example 1) 1.0 Preservative (appropriate amount) Purified water, remaining amount (total volume is 100)

[0125] Example of formulation 6: Gommage A scrub with the following composition was manufactured using a conventional method. Ingredients Amount (mass%) Squalane 5.0 Stearic acid 1.0 Glyceryl stearate 1.0 PEG-60 Hydrogenated Castor Oil 1.0 Dimethicone 0.5 Glycerin 2.5 1,3-Butylene glycol 2.5 Polyisoprene 5.0 α-hydroxy acid mixture 0.5 Carbomer 0.2 Potassium hydroxide (appropriate amount) Clear Rose Fruit (manufactured by Maruzen Pharmaceutical Co., Ltd.) 3.0 Sea mud extract (Test example 1) 0.3 Preservative (appropriate amount) Purified water, remaining amount (total volume is 100)

Claims

1. A pore-minimizing agent characterized by containing sea mud extract and rosehip extract.

2. The pore-concealing agent according to claim 1, characterized in that it contains 0.001 to 5000 parts by mass of sea mud extract per 1 part by mass of rosehip extract.

3. A cosmetic product for improving the appearance of pores, characterized by containing sea mud extract and rosehip extract.

4. A topical skin preparation characterized by containing sea mud extract and rosehip extract.

5. The topical skin preparation according to claim 4, characterized in that it contains 0.001 to 5000 parts by mass of sea mud extract per 1 part by mass of rosehip extract.

6. The topical skin preparation according to claim 4, characterized by containing 0.001 to 5000 parts by mass of sea mud extract per 1 part by mass of rosehip extract.

7. The topical skin preparation according to claim 4, characterized by containing 0.001 to 5000 parts by mass of sea mud extract per 1 part by mass of rosehip extract.

8. The topical skin preparation according to claim 4, characterized by containing 0.5 to 5000 parts by mass of sea mud extract per 1 part by mass of rosehip extract.

9. Use of sea mud extract and rosehip for the manufacture of pore-minimizing agents, pore-minimizing cosmetics, or topical skin preparations.

10. The use described in claim 9, wherein the pore-minimizing agent, pore-minimizing cosmetic, or topical skin preparation contains 0.001 to 5000 parts by mass of sea mud extract per 1 part by mass of rosehip extract.

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