Carbonated aerosol topical skin preparation

Abstract

A carbonated aerosol topical skin preparation in which ceramide lipids are stably emulsified and which has excellent moisture retention and spreadability. 【Solution means】A carbonated aerosol topical skin preparation comprising an aerosol stock solution containing the following components (A) to (D) and a propellant containing component (E), wherein the content of component (A) is 0.075 to 5.0% by mass, the mass ratio (A) / (B) of component (A) and component (B) is 0.2 or more and 15 or less, the mass ratio (A) / (C) of component (A) and component (C) is 0.01 or more and 40 or less, and the mass ratio (C) / (B) of component (C) and component (B) is 0.20 or more and 0.8 or less. (A) Ceramide lipid (B) An ionic surfactant selected from the following (B1) anionic surfactant, (B2) cationic surfactant, and (B3) amphoteric surfactant (B1) Specific anionic surfactant (B2) Specific cationic surfactant (B3) Specific amphoteric surfactant (C) Specific water-soluble polymer (D) Water (E) Carbon dioxide gas

Description

[Technical Field]

[0001] This invention relates to a carbonated aerosol skin preparation. [Background technology]

[0002] The stratum corneum, the outermost layer of the skin, is responsible for preventing the entry of substances from the outside and the evaporation of moisture from within the skin. At the same time as suppressing it, it retains moisture, which improves the skin's flexibility and smooth appearance. It has a function of maintaining this. The spaces between the keratinocytes that make up the stratum corneum contain what are called intercellular lipids. These lipids are present, filling the gaps between keratinocytes.

[0003] Approximately 50% of the lipid composition of these intercellular lipids in the stratum corneum is ceramide lipids, and a decrease in ceramide lipids... This is known to cause undesirable skin conditions such as rough skin, dry skin, and aging skin. Therefore, supplementing with ceramide lipids topically improves the condition of the stratum corneum, which has lost its function. It is believed that this is possible.

[0004] However, ceramide lipids are highly crystalline and have a high melting point, making them difficult to stabilize in pharmaceutical formulations. This presents a problem. Therefore, in order to stably incorporate ceramides into topical skin preparations, a specific interface is used. It has been proposed to combine it with activators or water-soluble polymers (see, for example, Patent Documents 1 and 2). see).

[0005] Carbon dioxide is known to promote blood circulation and have a warming effect, and is used as a propellant. Aerosol-type cosmetics using [a specific substance] are used. For example, Patent Document 3 describes [a specific substance]. The propellant contains solid lipids, powders of a specific particle size, and nonionic surfactants, and is suitable for use on the skin. An aerosol cosmetic with excellent transparency has been disclosed. [Prior art documents]

Patent Documents

[0006]

Patent Document 1

Patent Document 2

Patent Document 3

Summary of the Invention

Problems to be Solved by the Invention

[0007] Therefore, the present inventors examined an aerosol skin external preparation containing ceramide lipid and using carbon dioxide gas as an aerosol agent. However, it was found that in an emulsion containing ceramide lipid, the emulsion stability is impaired when carbon dioxide gas coexists, and particularly at high temperatures, the ceramide lipid is likely to precipitate, resulting in a problem that ejection from the aerosol container becomes impossible. Therefore, the present inventors examined an aerosol skin external preparation containing ceramide lipid and using carbon dioxide gas as an aerosol agent. However, it was found that in an emulsion containing ceramide lipid, the emulsion stability is impaired when carbon dioxide gas coexists, and particularly at high temperatures, the ceramide lipid is likely to precipitate, resulting in a problem that ejection from the aerosol container becomes impossible. Therefore, the present inventors examined an aerosol skin external preparation containing ceramide lipid and using carbon dioxide gas as an aerosol agent. However, it was found that in an emulsion containing ceramide lipid, the emulsion stability is impaired when carbon dioxide gas coexists, and particularly at high temperatures, the ceramide lipid is likely to precipitate, resulting in a problem that ejection from the aerosol container becomes impossible. Therefore, the present inventors examined an aerosol skin external preparation containing ceramide lipid and using carbon dioxide gas as an aerosol agent. However, it was found that in an emulsion containing ceramide lipid, the emulsion stability is impaired when carbon dioxide gas coexists, and particularly at high temperatures, the ceramide lipid is likely to precipitate, resulting in a problem that ejection from the aerosol container becomes impossible.

[0008] Therefore, the present invention relates to a carbon dioxide aerosol skin external preparation in which ceramide lipid is stably emulsified and which is excellent in moisturizing property and spreadability. Therefore, the present invention relates to a carbon dioxide aerosol skin external preparation in which ceramide lipid is stably emulsified and which is excellent in moisturizing property and spreadability.

Means for Solving the Problems

[0009] The present inventors have found that by using carbon dioxide gas as an aerosol agent and combining ceramide lipid with an ionic surfactant and a water-soluble polymer, an aerosol skin external preparation excellent in emulsion stability, moisturizing property, and spreadability can be obtained. The present inventors have found that by using carbon dioxide gas as an aerosol agent and combining ceramide lipid with an ionic surfactant and a water-soluble polymer, an aerosol skin external preparation excellent in emulsion stability, moisturizing property, and spreadability can be obtained. The present inventors have found that by using carbon dioxide gas as an aerosol agent and combining ceramide lipid with an ionic surfactant and a water-soluble polymer, an aerosol skin external preparation excellent in emulsion stability, moisturizing property, and spreadability can be obtained.

[0010] The present invention provides a carbon dioxide aerosol skin external preparation comprising an aerosol stock solution containing the following components (A) to (D) and an aerosol agent containing a component (E). The present invention provides a carbon dioxide aerosol skin external preparation comprising an aerosol stock solution containing the following components (A) to (D) and an aerosol agent containing a component (E). (A) Ceramide lipid (B) Ionic surfactants (C) Water-soluble polymer (D) Water (E) Carbon dioxide [Effects of the Invention]

[0011] The carbonated aerosol skin preparation of the present invention provides stable emulsification of ceramide lipids and excellent It has moisturizing properties and is easy to apply. [Modes for carrying out the invention]

[0012] ● Aerosol concentrate The aerosol concentrate in the carbonated aerosol skin topical preparation of the present invention contains the following components (A) to (D) To possess.

[0013] [Component (A): Ceramide lipids] The ceramide lipid in component (A) can be either natural ceramide or pseudo-ceramide. It is preferable that it includes one or more types selected from those represented by the following general formulas (1) or (2). It's nice.

[0014] Natural ceramides are represented by general formula (1) and are naturally derived ceramides or synthetic compounds of the same structure. That's fine.

[0015] [ka]

[0016] [In the formula, R 1 This is a linear, branched, or ring-shaped molecule with 7 to 19 carbon atoms, which may be substituted with hydroxyl groups. It shows saturated or unsaturated hydrocarbon groups in a certain form; Z 1 X indicates a methylene group or methine group; 1 , X 2 , and X 3 Each of these independently represents a hydrogen atom, a hydroxyl group, or an acetoxy group; X 4 is water represents a sulfur atom or forms an oxo group together with an adjacent oxygen atom (provided that when Z 1 is a methyl group, either one of X 1 and X 2 is a hydrogen atom and the other does not exist. When X 4 forms an oxo group, X 3 does not exist.); R 2 represents a hydroxymethyl group or an acetoxym ethyl group; R 3 represents a hydrogen atom or an alkyl group having 1 to 4 carbon atoms; R 4 is hydro xy group may be substituted with a linear, branched or cyclic saturated or unsaturated hydrocarbon group having 5 to 30 carbon atoms, or at the ω-end of the alkyl group, a hydroxyl group may be substituted with a linear or branched saturated or unsaturated fatty acid having 8 to 22 carbon atoms ester-bonded thereto is shown; the dashed line indicates that it may be an unsaturated bond.〕

[0017] In the general formula (1), preferably, R 1 has 7 to 19 carbon atoms, more preferably 13 to 15 carbon atoms linear alkyl group; R 4 is a linear alkyl group having 9 to 27 carbon atoms which may be substituted with a hydroxyl group or a linear alkyl group having 9 to 27 carbon atoms ester-bonded with linoleic acid is exemplified. Also, X 4 preferably represents a hydrogen atom or forms an oxo group together with an oxygen atom is preferred. In particular, as R 4 , tricosyl, 1-hydroxypentadecyl, 1-hydroxytricos syl, heptadecyl, 1-hydroxyundecyl, and nonacyl group ester-bonded with linoleic acid at the ω-position are preferred .

[0018] Natural ceramides include sphingosine, dihydrosphingosine, and phytosphingosine. Alternatively, sphingadienin is amidated ceramide type 1-7 (e.g., J. Lipid Res Figure 2 of .,24:759(1983) and Figure 4 of J. Lipid. Res.,35:2069(1994) It is preferable to select one or more from (human and ceramides). Furthermore, these This also includes N-alkyl compounds (e.g., N-methyl compounds).

[0019] These natural ceramides, even when using the optically active natural (D(-)) form, are also available in non-natural forms. The optically active L(+) form may be used, or a mixture of the natural and unnatural forms may be used. The relative stereochemistry of the compound can be that of the natural stereochemistry or other unnatural stereochemistry. It may be a single substance, or a mixture thereof. In particular, CERAMIDE1, C Compounds of ERAMIDE2, CERAMIDE3, CERAMIDE5, CERAMIDE6II (INCI, 8th Edition) and It is preferable to select one or more from those represented by the following formulas.

[0020] [ka]

[0021] These can be either natural extracts or synthetic compounds, and commercially available products can be used. It is possible. When using commercially available natural ceramides, Ceramide I, Cera mide III, Ceramide IIIA, Ceramide IIIB, Ceramide IIIC, Ceramide VI (all of the above are Cosmo Farm Co., Ltd., Ceramide TIC-001 (Takasago International Corporation), CERAMIDE II (Quest International Corporation) ), DS-Ceramide VI, DS-CLA-Phytoceramide, C6-Phytoceramide, DS-ceramide Y3S(DOO Preferably, one or more types selected from SAN (Sedama Corporation) and CERAMIDE2 (Sedama Corporation) are used.

[0022] [ka]

[0023] Pseudoceramides are represented by general formula (2).

[0024] [ka]

[0025] [In the formula, R 5 This refers to a linear or branched chain of 10 to 22 carbon atoms, which may be substituted with a hydroxyl group. く indicates a cyclic saturated or unsaturated hydrocarbon group or a hydrogen atom; X 5 is a hydrogen atom, acetate R indicates a tyl group or a glyceryl group; 6 It may be substituted with a hydroxyl group or an amino group. i A linear, branched, or cyclic saturated or unsaturated hydrocarbon group having 5 to 22 carbon atoms, or A linear or fractional hydrocarbon having 8 to 22 carbon atoms, in which a hydroxyl group may be substituted at the ω-terminus of the hydrocarbon group. This refers to a chain of saturated or unsaturated fatty acids linked by esterification; R 7 Does this indicate a hydrogen atom? , substituted with a hydroxyl group, hydroxyalkoxy group, alkoxy group or acetoxy group This indicates an alkyl group with a total of 1 to 30 carbon atoms that may be present.

[0026] R 6In particular, nonyl, tridecyl, pentadecyl, and linoleic acid esterified at the ω position. A bonded undecyl group, a pentadecyl group with linoleic acid ester-bonded to the ω position, and 1 at the ω position 2-hydroxystearic acid is esterified to a pentadecyl group, with a methyl branched iso at the ω position. A stearic acid atom bonded to an undecyl group via an amide linkage is preferred.

[0027] R 7 R 5 If it is a hydrogen atom, it is a hydroxyl group, a hydroxyalkoxy group, or an aluminum group. A carbon atom having 10 to 30 carbon atoms, which may be substituted with a coxy group or an acetoxy group, preferably a carbon atom It is an alkyl group with 12 to 20 atoms, R 5 A carbon atom with 10 to 22 carbon atoms may be substituted with a hydroxyl group. If it is a linear, branched, or cyclic saturated or unsaturated hydrocarbon group, then it is a hydrogen atom. , substituted with a hydroxyl group, hydroxyalkoxy group, alkoxy group or acetoxy group It is preferable that the alkyl group has a total of 1 to 8 carbon atoms. 7 hydroxyalco The xy group or alkoxy group is preferably one having 1 to 7 carbon atoms.

[0028] As a pseudo-ceramide represented by general formula (2), R is shown in the following formula. 5 is a hexadecyl group , X 5 is a hydrogen atom, R 6 is a pentadecyl group, R 7 Those whose group is a hydroxyethyl group (that is, (N-(hexadecyloxyhydroxypropyl)-N-hydroxyethylhexadecanamide) ;R 5 is a hexadecyl group, X 5 is a hydrogen atom, R 6 is a nonyl group, R 7 is a hydroxyethyl group (i.e., N-(hexadecyloxyhydroxypropyl)-N-hydroxyethyldeca It is preferable to select one or more from namide, with the former being more preferable.

[0029] [ka]

[0030] The amount of component (A) in the aerosol concentrate improves moisturizing effect, emulsification stability, and applicability. From this viewpoint, preferably 0.001% by mass or more, more preferably 0.01% by mass or more, even more preferably The amount is 0.075% by mass or more, more preferably 0.1% by mass or more, and also preferably 15% by mass. More preferably 10% by mass or less, even more preferably 5.0% by mass or less, and even more preferably 3.0% by mass or less. It is less than or equal to mass%. The specific range of the content of component (A) in the aerosol concentrate is preferred. The amount is 0.001 to 15% by mass, more preferably 0.010 to 10% by mass, and even more preferably 0.075 to 5.0% by mass. The amount is %, more preferably 0.1 to 3.0% by mass.

[0031] [Ingredient (B): Ionic surfactant] The ionic surfactants in component (B) include anionic surfactants and cationic surfactants. Either a surfactant or an amphoteric surfactant can be used.

[0032] Examples of anionic surfactants include N-acyl amino acids, fatty acids, and alkyl ethers. Acyl lactic acid, polyoxyethylene alkyl ether carboxylic acid, acyl lactic acid, N-acyl methyl ammonium Carboxylate salts such as ranine, N-acyl sarcosine, diacyl amino acids and their salts; Lucansulfonic acid, α-olefin sulfonic acid, α-sulfo fatty acid methyl ester, acyl Isethionic acid, alkyl sulfosuccinate, N-acylmethyl taurine and their salts, etc. Alfonate type; alkyl sulfate ester, polyoxyethylene alkyl sulfate ester, aldehyde Polyoxyethylene alkyl ether sulfate, fatty acid alkanols Sulfate-type esters such as sulfuric acid esters and their salts; alkyl phosphate esters, polyoxyethylene One or more phosphate types selected from lenalkyl ether phosphates and their salts. Preferably, the above is included, and from the viewpoint of improving emulsification stability, N-acyl amino acids, fatty acids, and Kill ether carboxylic acid, diacyl glutamate lysine, alkyl sulfosuccinate, N-A Silmethyl taurine, alkyl sulfate, polyoxyethylene alkyl sulfate Alkyl phosphate esters, polyoxyethylene alkyl ether phosphates and their salts It is preferable to include one or more selected from the following.

[0033] Of these, N-acyl amino acids, fatty acids, alkyl ether carboxylic acids, diacyl glycan Lysine lutamate, alkyl sulfosuccinate, N-acylmethyl taurine, alkyl sulfate Stel, polyoxyethylene alkyl sulfate, polyoxyethylene alkyl ether It is preferable to include one or more selected from phosphates and their salts. Furthermore, N-acyl amino acids, fatty acids, alkyl ether carboxylic acids, diacyl glutamate lysine Alkyl sulfosuccinate, N-acylmethyl taurine, polyoxyethylene alkyl sulfate One selected from esters, polyoxyethylene alkyl ether phosphates, and salts thereof. Or, it is more preferable to include two or more types. Also, N-acyl amino acids, fatty acids, diacylg Lysine lutamate, N-acylmethyl taurine, polyoxyethylene alkyl ether phosphate It is more preferable to include one or more selected from acids and their salts, and N-acyla Mino acids, N-acylmethyl taurine are more preferred, and N-stearoyl glutamate sodium It is even more preferable to include N-stearoyl-N-methyltaurate sodium.

[0034] N-acylmethyltaurine and its salts include N-myristoyl-N-methyltaurine, N- Examples include lauroyl-N-methyltaurine, N-stearoyl-N-methyltaurine, and their salts. Examples of N-acyl amino acids and their salts include N-lauroyl-L-glutamic acid, N-s N-acyl glutamates such as thearoyl-L-glutamic acid and N-myristoyl-L-glutamic acid Examples include lauric acid, palmitic acid, and sulfamethoxazole. Examples include fatty acids with 12 to 24 carbon atoms, such as thearic acid, and their salts. Alkyl ether carb Examples of acetic acid and its salts include polyoxyethylene lauryl ether acetate and its salts. It can be used. Diacyl glutamate lysine and its salts include dilauroyl glutamate lysine. Examples include syn and its salts. Examples of alkyl sulfosuccinic acid and its salts include di-2- Examples include ethylhexyl sulfosuccinic acid and its salts. Alkyl sulfates and so Examples of salts include lauryl sulfate and its salts. Examples of lauryl sulfate esters and their salts include polyoxyethylene lauryl sulfate and its salts. Examples of alkyl phosphates and their salts include monomyristyl phosphate and monostearyl phosphate. Examples include phosphoric acid, di(C12-15)pareth-8-phosphate and their salts. Examples of lenalkyl phosphates and their salts include polyoxyethylene oleyl ether phosphate. Polyoxyethylene cetyl ether phosphate, polyoxyethylene stearyl ether phosphate Examples include acids and their salts.

[0035] The salt structures that make up these salts include alkali metal salts such as sodium salts and potassium salts. Basic amino acid salts such as L-arginine salt, L-histidine salt, and L-lysine salt; triethanol Examples include alkanolamine salts such as amine salts. These anionic surfactants are used individually. You can use one or more types.

[0036] Cationic surfactants include sphingosine salts, aliphatic amine salts, and quaternary ammonium compounds. Selected from nium salts, DL-pyrrolidone carboxylate salts, alkylamidoamines and their salts. Preferably containing one or more types, and from the viewpoint of improving moisturizing effect and emulsion stability, sulfite Ingosine salts, monoC12-24 alkyltrimethylammonium salts, diC12-24 alkyldimethyl Tylammonium salt, diacylethylhydroxyethylmonium methosulfate, acylammonium salt Selected from arginine ethylpyrrolidone carboxylate salts and alkylamidoamine salts. It is more preferable to contain one or two or more types, including phytosphingosingolephate, di Stearyldimethylammonium chloride, behenamidopropyldimethylamine lactate It is even more preferable to include one or more selected types.

[0037] As for mono-C12-24 alkyltrimethylammonium salts, lauryltrimethylammonium Ammonia chloride, stearyltrimethylammonium chloride, behenyltrimethylammonium Examples include nium chlorides. DiC12-24 alkyldimethylammonium salts include di Lauryldimethylammonium chloride, distearyldimethylammonium chloride, Examples include dibehenyldimethylammonium chloride. As for tylmonium methosulfate, dicocoylethylhydroxyethylmonium methosulfate is used. Examples include tosulfate, as well as acylarginine ethylpyrrolidone carboxylate. Examples include cocoyl arginine ethylpyrrolidone carboxylate salt. Alkylamide As an amine salt, N-(3-(dimethylamino)propyl)docosanamide (also known as behenamide) Examples include propyldimethylamine and its salts. These cationic surfactants are One or more types may be used.

[0038] Among the cationic surfactants used in the present invention, sphingosine salts are sphingosine It is composed of sphingosine compounds and acidic substances. Sphingosine compounds include naturally occurring sphingosine compounds. Sphingosine compounds or compounds having the same structure, and their derivatives (hereinafter referred to as natural sphingosine) (or pseudo-sphingosines having a sphingosine structure (hereinafter referred to as pseudo-sphingosine) It is preferable to write it as "Shin".

[0039] Specifically, natural sphingosine includes natural sphingosine and dihydrosphingine. Gosine, phytosphingosine, sphingadienine, dehydrosphingosine, dehyd Examples include lophytosphingosine and its N-alkyl derivatives (e.g., N-methyl derivatives). These sphingosines, even when using the optically active form of the natural type (D(+)), are also active in the non-natural type. The optically active (L(-) isomer) may be used, or a mixture of the natural and unnatural forms may be used. The relative stereochemistry of the above compounds can be the natural stereochemistry or other unnatural stereochemistry. It may be in a specific arrangement, or it may be a mixture of these. Furthermore, PHYTOSPHINGOSI NE (INCI name; 8th Edition) and those represented by the following formula are preferred.

[0040] [ka]

[0041] These can be either natural extracts or synthetic compounds, and commercially available products can be used. Yes, it is possible. A commercially available natural form of sphingosine is, for example, D-Sphingosine(4-Sphi ngenine) (SIGMA-ALDRICH), DS-phytosphingosine (DOOSAN), phytosphingosine (Cosmo Farm Co., Ltd.) is one example.

[0042] Specific examples of pseudo-sphingosines include the following pseudo-sphingosines (i) to (iv), and Examples include 1-(2-hydroxyethylamino)-3-isostearyloxy-2-propanol. .

[0043] [ka]

[0044] Sphingosine species include natural sphingosine, phytosphingosine, and pseudo-sphingosine. Sphingosine is preferred, pseudo-sphingosine is more preferred, and pseudo-sphingosine (ii), 1-(2-hydroxyethylamino)-3-isostearyloxy-2-propanol It is preferable.

[0045] These natural forms of sphingosine, phytosphingosine, pseudosphingosine, and salt The acidic substances that make up the compound include acidic amino acids such as glutamic acid and aspartic acid; and phosphoric acid. , inorganic acids such as hydrochloric acid; monocarboxylic acids such as acetic acid; dicarboxylic acids such as succinic acid; citric acid, milk Examples include acids and oxycarboxylic acids such as malic acid. Among these, naturally occurring sphingons are particularly noteworthy. Gosin, phytosphingosin, or pseudosphingosin (ii ), succinyl (1-(2-hydroxyethylamino)-3-isostearyloxy-2-propanol) Salts, lactates, and glutamates are preferred, as are natural sphingosine and phytosphingosine. Phytosphingosine, or a glutamate of pseudosphingosine, is more preferred. ngulfamate salts are even more preferred.

[0046] Examples of amphoteric surfactants include phospholipids, alkyldimethylamine oxide, and alkylka Ruboxybetaine, alkylsulfobetaine, amide amino acid salt, alkylamidopropyl Betaine is one example, and among them alkylamidopropyl betaine, soybean phospholipid, hydrogen Added soybean phospholipids are preferred, and hydrogenated soybean phospholipids are even more preferred.

[0047] The content of component (B) in the aerosol concentrate should be considered from the perspective of improving moisturizing effect and emulsion stability. Preferably 0.01% by mass or more, more preferably 0.05% by mass or more, and even more preferably 0.075% It is % by mass or more, more preferably 0.15% by mass or more, and also preferably 5.0% by mass or less. More preferably 2.0% by mass or less, even more preferably 0.75% by mass or less, and even more preferably 0.50% by mass The amount is less than or equal to %. The specific range of the content of component (B) in the aerosol concentrate is preferably The amount is 0.01 to 5.0 mass%, more preferably 0.05 to 2.0 mass%, and even more preferably 0.075 to 0.75 mass %, more preferably 0.15 to 0.50 mass%.

[0048] The mass ratio (A) / (B) of component (A) to component (B) in the aerosol concentrate indicates emulsification stability and moisturizing effect. From the viewpoint of improving the effect and applicability, preferably 0.003 or more, more preferably 0.03 or more, Preferably 0.3 or higher, more preferably 100 or lower, more preferably 30 or lower, even more preferably The ratio is 15 or less. The mass ratio (A) / (B) of component (A) to component (B) in the aerosol concentrate is The specific range is preferably 0.003 to 100, more preferably 0.03 to 30, and even more preferably 0.3 to 1 The answer is 5.

[0049] [Component (C): Water-soluble polymer] The water-soluble polymer of component (C) is not restricted as long as it is one that is commonly used in topical skin preparations. Furthermore, plant-derived polymers, microbial polymers, mucopolysaccharides, cellulose-based polymers, and starch-based polymers are also included. Examples include molecules, vinyl polymers, acrylic polymers, and polyoxyethylene polymers. The weight-average molecular weight of the water-soluble polymer of component (C) is preferably 10,000 or more. The uniform molecular weight was determined by gel permeation chromatography using polyethylene oxide as the standard substance. By using the GPC-Multi-Angle Laser Scattering Detection (MALLS) system, It is determined.

[0050] Examples of plant-derived polymers include gum arabic, locust bean gum, guar gum, and karayaga gum. Carrageenan, pectin, agar, starch (rice, corn, potato, corn) Examples include (G), and examples of microbial polymers include xanthan gum and gellan gum. Examples of mucopolysaccharides include hyaluronic acid, tuberose polysaccharide, and Tremella fuciformis polysaccharide. Examples include methylcellulose, ethylcellulose, and cellulose polymers. Boxymethylcellulose, hydroxymethylcellulose, hydroxyethylcellulose hydroxypropylcellulose, hydroxypropylmethylcellulose, hydroxypropyl Ropilmethylcellulose stearoxate ether, nitrocellulose, sodium cellulose sulfate Lilium, sodium carboxymethylcellulose, crystalline cellulose, cellulose powder, hydr Examples include sodium oxypropylsulfonate. Examples of starch-based polymers include Calcium. Examples include methyl methyl starch and methyl hydroxypropyl starch. Vinyl-based high Examples of molecules include polyvinyl methyl ether and polyvinylpyrrolidone. Examples of lyl polymers include alkyl-modified carboxyvinyl polymers and carboxyvinyl polymers. Mer, sodium polyacrylate, polyethyl acrylate, polyacrylamide, A Acrylic acid / alkyl acrylate copolymer, acrylic acid / alkyl methacrylate copolymer (Sodium acrylate / sodium acryloyldimethyl taurate) copolymer, polyacrylate Rosspolymer-6, N,N-dimethylaminoethyl methacrylate diethyl sulfate, N,N-dimethyl Acrylamide / polyethylene glycol dimethacrylate copolymer, 2-methacryloyl Examples include oxyethyl phosphorylcholine / butyl methacrylate copolymers. Examples of ethylene-based polymers include polyethylene oxide. Among these, milk From the standpoint of improving chemical stability and coatability, microbial polymers, cellulose polymers and acrylic polymers Polymers are preferred.

[0051] As microbial polymers, xanthan gum and gellan gum are preferred, and xanthan gum This is more preferable. As for cellulosic polymers, hydroxypropylmethylcellulose, Hydroxyethylcellulose, hydroxypropylmethylcellulose stearoxyethyl Preferably, hydroxypropyl methylcellulose, hydroxypropyl methylcellulose -Stearooxyether is more preferred. As for acrylic polymers, alkyl-modified catechu Ruboxyvinyl polymer, carboxyvinyl polymer, acrylic acid / (meth)acrylic acid Alkyl copolymer, N,N-dimethylaminoethyl methacrylate diethyl sulfate, N,N-dimethylaminoethyl methacrylate Polyethylene glycol dimethacrylate copolymer, 2-methacryloy A copolymer of hydroxyethyl phosphorylcholine and butyl methacrylate is preferred, (acrylic Acid / alkyl (C10-30) acrylate copolymer is more preferred. Here, (acrylic acid Alkyl acrylate (C10-30) copolymer is a copolymer of C10-30 alkyl acrylic acid and acrylic acid. Copolymers of sucrose, methacrylic acid, or lower alkyl esters thereof It is a crosslinked product with allyl ether or pentaerythritol allyl ether, and Pem Ren TR-1, Pemlen TR-2, Carbopol ETD2020, Carbopol 1342, Carbopol 1382 Commercially available products such as those from Lubrizol Advanced Materials can be used.

[0052] Of these, component (C) is hydroxypropyl methylcellulose, hydroxypropyl Ropyrmethylcellulose stearoxy ether, carboxyvinyl polymer, alkyl compound Carboxylic carboxyvinyl polymer, acrylic acid / (meth)acrylate alkyl copolymer, and Selected from 2-methacryloyloxyethyl phosphorylcholine / butyl methacrylate copolymer Preferably contains one or more types, such as hydroxypropyl methylcellulose, (acrylic Alkaline Acid / Alkyl Acrylate (C10-30) Copolymer, 2-Methacryloyloxyethyl Phosphate It is more preferable to include one or more selected from the folylcone-butyl methacrylate copolymer. It's nice.

[0053] The content of component (C) in the aerosol concentrate is determined from the perspective of improving emulsification stability and applicability. Preferably 0.010% by mass or more, more preferably 0.025% by mass or more, and even more preferably 0.050% by mass It is % by mass or more, more preferably 0.075% by mass or more, and also preferably 2.0% by mass or less. More preferably 0.60% by mass or less, even more preferably 0.30% by mass or less, and even more preferably 0.20% by mass The amount is less than or equal to %. The specific range of the content of component (C) in the aerosol concentrate is preferably The amount is 0.010 to 2.0 mass%, more preferably 0.025 to 0.60 mass%, and even more preferably 0.050 to 0.30 mass. The amount is %, more preferably 0.075 to 0.20 mass%.

[0054] The mass ratio (A) / (C) of component (A) to component (C) in the aerosol concentrate indicates emulsification stability and moisturizing effect. From the viewpoint of improving the fruit and applicability, preferably 0.01 or higher, more preferably 0.10 or higher, and further Preferably 0.50 or higher, more preferably 0.75 or higher, and even more preferably 1.0 or higher, Preferably 150 or less, more preferably 100 or less, even more preferably 40 or less, and even more preferably 30 The following is more preferably 20 or less: The mass of component (A) and component (C) in the aerosol concentrate. The specific range of the ratio (A) / (C) is preferably 0.01 to 150, more preferably 0.10 to 100, and even more preferably More preferably 0.50 to 40, more preferably 0.75 to 30, and even more preferably 1.0 to 20.

[0055] The mass ratio (C) / (B) of component (C) to component (B) in the aerosol concentrate is important from the perspective of emulsification stability. Preferably 0.01 or higher, more preferably 0.05 or higher, even more preferably 0.10 or higher, even more preferably It is more or less than 0.20, preferably less than or equal to 10, more preferably less than or equal to 5, and even more preferably less than or equal to 5. The ratio is 1.5 or less, more preferably 0.8 or less. Component (C) and component (B) in the aerosol concentrate. The specific range of the mass ratio (C) / (B) is preferably 0.01 to 10, more preferably 0.05 to 5, and further Preferably, it is 0.10 to 1.5, and more preferably 0.20 to 0.8.

[0056] [Component (D): Water] The water content of component (D) in the aerosol concentrate affects emulsification stability and carbon dioxide solubility. From this viewpoint, preferably 50% by mass or more, more preferably 60% by mass or more, and even more preferably 70% by mass It is % by amount or more, more preferably 75% by mass or more, and more preferably 98% by mass or less, even more preferably More preferably 95% by mass or less, more preferably 90% by mass or less, and even more preferably 85% by mass or less. The specific range of the content of component (D) in the aerosol concentrate is preferably 50 to 98 by mass. %, more preferably 60-95% by mass, even more preferably 70-90% by mass, even more preferably 75-85% It is expressed as mass percent.

[0057] [Nonionic surfactants] The aerosol concentrate may further contain a nonionic surfactant. Examples of surfactants include sorbitan fatty acid esters (e.g., monostearic acid). Sorbitan, etc., glycerin fatty acid esters (e.g., glyceryl monostearate, etc.) Polyglycerin fatty acid ester, propylene glycol fatty acid ester, polyethylene Glycol fatty acid esters, sucrose fatty acid esters, polyoxyethylene fatty acid esters , polyoxyethylene sorbitan fatty acid ester (for example, polyoxy monostearate) Ethylene (20) sorbitan (polysorbate 60, etc.), polyoxyethylene alkyl ether Alkyl glyceryl ether, polyoxyethylene sorbitol fatty acid ester, Polyoxyethylene glycerin fatty acid ester, polyoxyethylene propylene glycol Fatty acid esters, polyoxyethylene castor oil, polyoxyethylene hydrogenated castor oil, poly Oxyethylene hydrogenated castor oil fatty acid ester, polyoxyethylene phytostanol A Polyoxyethylene phytosterose ether, polyoxyethylene cholesterol ether, polyoxyethylene cholesteryl ether, polyoxyalkylene modified ether Ganopolysiloxanes, polyoxyalkylene-alkyl-comodified organopolysiloxanes, etc. These are some examples.

[0058] Of these, sorbitan fatty acid ester, from the viewpoint of improving moisturizing effect and emulsion stability, Glycerin fatty acid ester, alkyl glyceryl ether, polyoxyethylene sorbita Fatty acid esters are preferred, such as sorbitan C12-22 fatty acid ester and glycerin monoC12-22. Fatty acid esters, monoC12-22 alkylglyceryl ethers, polyoxyethylene sorbita C12-22 fatty acid esters are more preferred, and polyoxyethylene sorbita monostearate is preferred. Furthermore, sorbitan monostearate is even more preferred.

[0059] [Other optional ingredients] The aerosol concentrate also contains a liquid oil at 25°C, a polyhydric alcohol, a thickener, a preservative, Powder, ethanol, antioxidant, colorant, pH adjuster, fragrance, humectant, blood circulation promoter, cooling agent, It may contain antiperspirants, antibacterial agents, whitening agents, anti-inflammatory agents, skin activators, etc. These drugs are not limited to their intended use as drugs, but may be repurposed for other uses or other purposes depending on the purpose. It can also be used for multiple purposes. For example, if you use antiperspirant as a fragrance, the antiperspirant and fragrance can be used together. It may be used to produce the desired effect.

[0060] Examples of liquid oils at 25°C include hydrocarbon oils, silicone oils, ester oils, ether oils, and fluorine oils. Examples include ester oils, and from the viewpoint of improving emulsification stability and applicability, hydrocarbon oils, ester oils and Silicone oil is preferred, as are hydrocarbon oils, monoester oils, triester oils, and silicones. Oil is more preferred, and monoester oil, triester oil, and silicone oil are even more preferred. Physically, for example, light isoparaffin, liquid paraffin, liquid isoparaffin, squalane Linear or branched hydrocarbon oils such as lan, squalene, etc.; cyclomethicone, dimethicone, trimethylamine Roxane methyl trimethicone, ethyl trisiloxane, methylphenylpolysiloxane, Methylhydrogenpolysiloxane, higher alcohol-modified organopolysiloxane, etc. Silicone oil; isononyl isononanoate, isotridecyl isononanoate, benzoic acid and carbon Monoesters of aliphatic alcohols of number 12 to 15, such as alkyl benzoates (C12-15). Steryl oil, diester oil such as neopentyl glycol dicaprate, tri(caprylic / capric) Triester oils such as glyceryl phosphate and triglyceryl 2-ethylhexanoate; alkyl 1,3-dimethylbutyl ether, dicaprylyl ether, dicaprylyl ether, etc. Fluorine oils; fluorine polyethers, perfluoroalkyl ethers, silicones, etc. Examples include oils. These may be of natural origin, such as plants. Note that liquid ultraviolet The radiation absorbent is also included in the oil, which is liquid at 25°C.

[0061] The amount of liquid oil at 25°C in the aerosol concentrate is determined from the perspective of improving the user experience. Preferably 0.01% by mass or more, more preferably 0.05% by mass or more, even more preferably 0.1% by mass It is % or more, preferably 5.0% by mass or less, more preferably 3.0% by mass or less, and even more preferably The amount is 1.0% by mass or less. The amount of liquid oil in the aerosol concentrate at 25°C is The specific range is preferably 0.01 to 5.0 mass%, more preferably 0.05 to 3.0 mass%, and 0.1 to 1.0 Mass percent is even more preferable.

[0062] Any polyhydric alcohol commonly used in cosmetics will suffice, for example, ethyl alcohol. ethylene glycol, propylene glycol, propanediol, 1,3-butylene glycol, 1,3-Propanediol, Dipropylene Glycol, Polyethylene Glycol, Polypropylene Divalent polyhydric alcohols such as lenglycol; trivalent or higher polyhydric alcohols such as glycerin and sorbitol. Examples include divalent and polyvalent alcohols. Of these, from the viewpoint of improving coating properties, divalent and polyvalent alcohols are used. As a component, propylene glycol, propanediol, 1,3-butylene glycol, 1,3- Propanediol, dipropylene glycol, and glycerol as a polyhydric alcohol of trivalent or higher More preferably, 1,3-propanediol, dipropylene glycol, and glycerin are further Preferably, it contains glycerin, and more preferably, glycerin.

[0063] The amount of polyhydric alcohol in the aerosol concentrate is important from the perspective of improving moisturizing properties and applicability. Preferably, 1% by mass or more, more preferably 2% by mass or more, and even more preferably 5% by mass or more. More preferably, it is 10% by mass or more, and more preferably 50% by mass or less, and more preferably The amount is 40% by mass or less, more preferably 30% by mass or less, and even more preferably 20% by mass or less. ~50% by mass is preferred, 2~40% by mass is more preferred, 5~30% by mass is even more preferred, and 10 ~20% by mass is even more preferable.

[0064] pH adjusters include organic acids, organic acid salts, amino acids, amino acid salts, amines, and inorganic acids. It may contain one or more pH adjusting agents selected from the group consisting of inorganic salts and inorganic bases. Organic acids include glycolic acid, citric acid, malic acid, succinic acid, tartaric acid, lactic acid, etc. Examples include potassium salts and sodium salts. Examples include glutamic acid, aspartic acid, arginine, lysine, etc., and their salts Examples include sodium salts, hydrochloride salts, succinate salts, etc. As for amines, monoethanolamines... Triethanolamine, triethanolamine, methylamine, ethylamine, trimethylamine, Aliphatic amines such as ethylamine, ethylenediamine, and tetramethylethylenediamine. Examples include phosphoric acid and other inorganic acids, and dihydrogen phosphate. Examples include potassium and disodium hydrogen phosphate. Lithium hydroxide is an example of an inorganic base. Examples include alkali metal hydroxides such as sodium hydroxide and potassium hydroxide. Of these, amino acids are preferred from the viewpoint of moisturizing properties, and arginine is even more preferred.

[0065] ● Propellant [Component (E): Carbon dioxide] In this invention, the propellant contains carbon dioxide, which is component (E). In addition to acid gas, other propellants can also be used in combination. For example, liquefied petroleum gas (ethane, propane, ethylene, isobutane, normal ethylene) Gases such as tane, propylene, etc., and their mixed gases (for example, isobutane and propane, propane and propylene) (Tan mixed gas, etc.), ether-based propellants (dimethyl ether, etc.), fluorocarbon (f (chlorofluorocarbons, bromochlorofluorocarbons, etc.), compressed gas (nitrogen) (Primary gases, air, mixtures of these gases, etc.), fluorocarbon gases (monochlorodifluoroethane, tetrafluoroethylene, etc.) Examples include ruoroethane, among which nitrogen, dimethyl ether, and liquefied petroleum gas are preferred. i. When using carbon dioxide of component (E) in combination with other propellants, either one alone or two or more The above combinations can be used.

[0066] When using a propellant other than carbon dioxide (component (E)) as a propellant, the effect of carbon dioxide will be diminished. From the perspective of not damaging the propellant, the ratio of carbon dioxide to component (E) in the total propellant should be in the gaseous state (10¹³). Based on volume at 25 hPa and 25°C, preferably 20% or more, more preferably 40% or more. More preferably 60% or more, and even more preferably 80% or more.

[0067] ● Carbonated aerosol topical skin preparation The carbon dioxide aerosol skin topical preparation of the present invention is prepared by preparing an aerosol stock solution containing components (A) to (D). It can be manufactured by filling a pressure vessel with a propellant containing component (E). The preferred form of spraying is a foam type, which dispenses the substance in a foamy state.

[0068] The ratio of (E) carbon dioxide to 100 parts by mass of aerosol concentrate is the ratio of carbon dioxide to aerosol concentrate. From the viewpoint of improving gas solubility, foam viscosity, and sprayability, preferably 0.01 parts by mass or more, more preferably or 0.10 parts by mass or more, more preferably 0.125 parts by mass or more, even more preferably 0.25 parts by mass or less More preferably 0.5 parts by mass or more, even more preferably 1.0 part by mass or more, and also preferred The amount is 5.0 parts by mass or less, more preferably 3.0 parts by mass or less.

[0069] Furthermore, the mass ratio (E) / (A) of component (E) and component (A) in the carbonated aerosol topical skin preparation of the present invention From the viewpoint of improving the emulsification stability and applicability of component (A), it is preferably 0.005 or higher, more preferably It is 0.10 or more, more preferably 0.2 or more, and also preferably 3000 or less, more preferably The value is 300 or less, and more preferably 30 or less.

[0070] The pH immediately after dispensing the carbonated aerosol topical skin preparation of the present invention is favorable from the viewpoint of emulsification stability. The value is 7.0 or less, more preferably 6.5 or less, and even more preferably 6.0 or less. Also, skin From the viewpoint of irritancy, preferably 2.0 or higher, more preferably 3.0 or higher, and even more preferably 4.0 or lower. The above. In this invention, the pH immediately after discharge refers to the pH at which the aerosol container is discharged under a 25°C environment. This refers to the pH measured one minute after discharge.

[0071] When the carbonated aerosol topical skin preparation of the present invention is of the foam type, the viscosity of the dispensed foam From the viewpoint of improving coatability, preferably 0.2 Pa·s or higher, more preferably 0.5 Pa·s or higher. More preferably 2.0 Pa·s or higher, even more preferably 5.0 Pa·s or higher, and also preferably 30 The pressure is Pa·s or less, more preferably 20 Pa·s or less, and even more preferably 10 Pa·s or less.

[0072] [How to use] The carbon dioxide aerosol skin preparation of the present invention is for use on skin, particularly on the skin of the entire body excluding the scalp, preferably... Apply an appropriate amount to the skin of the face, body, limbs, etc., more preferably the hands and feet. It can be applied to the target area by spreading it on, or dispensed directly onto the target area. In that case, it is preferable to take it in your hand and apply it without crushing the foam. Especially on hands, feet, and other areas. It is preferable to apply it to areas with thick, dry stratum corneum, such as fingers, heels, elbows, and knees. Approximately 1 gram is preferable for both hands.

[0073] With respect to the embodiments described above, preferred embodiments of the present invention are further disclosed below.

[0074] <1> The aerosol concentrate contains the following ingredients (A) to (D) and the propellant contains ingredient (E). A carbonated aerosol skin preparation. (A) Ceramide lipids (B) Ionic surfactants (C) Water-soluble polymer (D) Water (E) Carbon dioxide

[0075] <2> The ceramide lipid of component (A) is preferably represented by the following general formula (1) or (2). Includes one or more selected from <1> The carbonated aerosol skin preparation described above.

[0076] [ka]

[0077] [In the formula, R 1 This is a linear, branched, or ring-shaped molecule with 7 to 19 carbon atoms, which may be substituted with hydroxyl groups. It shows saturated or unsaturated hydrocarbon groups in a certain form; Z 1 X indicates a methylene group or methine group; 1 , X 2 , and X 3 Each of these independently represents a hydrogen atom, a hydroxyl group, or an acetoxy group; X 4 is water It either shows an elementary atom or forms an oxo group together with an adjacent oxygen atom (however, Z 1 ga Mechi When it is an N group, X 1 and X 2 One of them is a hydrogen atom, and the other does not exist. 4 ga oki When forming a so group, X 3 It does not exist. );R 2 is a hydroxymethyl group or acetoximethyl R indicates a til group; 3 R represents a hydrogen atom or an alkyl group having 1 to 4 carbon atoms; 4 is hydro A linear, branched, or cyclic saturated or unsaturated carbon atom having 5 to 30 carbon atoms, which may be substituted with xyl groups. It may be a hydrocarbon group, or a hydroxyl group may be substituted at the ω-terminus of the alkyl group. This refers to a structure in which saturated or unsaturated fatty acids with 8 to 22 carbon atoms in a straight or branched chain are esterified. The dashed lines indicate that the bond may be unsaturated.

[0078] [ka]

[0079] [In the formula, R 5 This refers to a linear or branched chain of 10 to 22 carbon atoms, which may be substituted with a hydroxyl group. く indicates a cyclic saturated or unsaturated hydrocarbon group or a hydrogen atom; X 5 is a hydrogen atom, acetate R indicates a tyl group or a glyceryl group; 6 It may be substituted with a hydroxyl group or an amino group. i A linear, branched, or cyclic saturated or unsaturated hydrocarbon group having 5 to 22 carbon atoms, or A linear or fractional hydrocarbon having 8 to 22 carbon atoms, in which a hydroxyl group may be substituted at the ω-terminus of the hydrocarbon group. This refers to a chain of saturated or unsaturated fatty acids linked by esterification; R 7 Does this indicate a hydrogen atom? , substituted with a hydroxyl group, hydroxyalkoxy group, alkoxy group or acetoxy group This indicates an alkyl group with a total of 1 to 30 carbon atoms that may be present.

[0080] <3> The content of component (A) in the aerosol concentrate is preferably 0.001% by mass or more. Preferably 0.01% by mass or more, more preferably 0.075% by mass or more, and even more preferably 0.1% by mass It is % or more, preferably 15% by mass or less, more preferably 10% by mass or less, and even more preferably More preferably 5.0% by mass or less, and even more preferably 3.0% by mass or less. <1> or <2> The charcoal described Acid aerosol topical skin preparation.

[0081] <4> Component (B) is preferably an N-acyl amino acid, a fatty acid, or an alkyl ether carb N-acyl methyl taurine, diacyl glutamate lysine, alkyl sulfosuccinate, N-acyl methyl taurine , alkyl sulfate esters, polyoxyethylene alkyl sulfate esters, alkyl phosphate esters Aniol selected from sterols, polyoxyethylene alkyl ether phosphates and their salts Non-toxic surfactants, sphingosine salts, aliphatic amine salts, quaternary ammonium salts, DL-P Cationic surfactant selected from roridone carboxylate salts, alkylamidoamines and their salts Selected from the following: fermentation agent, alkylamidopropyl betaine, soybean phospholipid and hydrogenated soybean phospholipid. It contains at least one selected from amphoteric surfactants. <1> ~ <3> Noi A carbonated aerosol skin preparation as described in item 1.

[0082] <5> The content of component (B) in the aerosol concentrate is preferably 0.01% by mass or more. Preferably 0.05% by mass or more, more preferably 0.075% by mass or more, and even more preferably 0.15% by mass It is % by amount or more, preferably 5.0% by mass or less, more preferably 2.0% by mass or less, and further Preferably 0.75% by mass or less, and more preferably 0.50% by mass or less. <1> ~ <4> Noise A carbonated aerosol skin preparation as described in item 1.

[0083] <6> The mass ratio (A) / (B) of component (A) to component (B) in the aerosol concentrate is preferably 0. It is 0.03 or higher, more preferably 0.03 or higher, even more preferably 0.3 or higher, and also preferably 10 It is 0 or less, more preferably 30 or less, and even more preferably 15 or less. <1> ~ <5> either A carbonated aerosol skin preparation as described in item 1.

[0084] <7> Component (C) is preferably a plant-derived polymer, a microbial polymer, a mucopolysaccharide, or cellulose. Polyethylene polymers, starch polymers, vinyl polymers, acrylic polymers, and polyoxyethylene polymers One or more selected polymers from the lemene group, more preferably hydroxypropylmethylcellulose S, hydroxypropyl methylcellulose stearoxy ether, carboxyvinyl poly Mer, alkyl-modified carboxyvinyl polymer, acrylic acid / (meth)acrylate Lucopolymer and 2-methacryloyloxyethyl phosphorylcholine / methacrylate butyl It contains one or more selected from the copolymer. <1> ~ <6> One of the following items A carbonated aerosol skin preparation.

[0085] <8> The content of component (C) in the aerosol concentrate is preferably 0.010% by mass or more. Preferably 0.025% by mass or more, more preferably 0.050% by mass or more, and even more preferably 0.075% by mass It is 1% by mass or more, preferably 2.0% by mass or less, more preferably 0.60% by mass or less. More preferably 0.30% by mass or less, and even more preferably 0.20% by mass or less. <1> ~ <7> of A carbonated aerosol skin preparation as described in any one of the items.

[0086] <9> The mass ratio (A) / (C) of component (A) to component (C) in the aerosol concentrate is preferably 0. 0.1 or higher, more preferably 0.10 or higher, even more preferably 0.50 or higher, even more preferably 0.75 or higher, More preferably it is 1.0 or higher, and more preferably 150 or lower, more preferably 100 or lower, Preferably 40 or less, more preferably 30 or less, and even more preferably 20 or less. <1> A carbonated aerosol skin preparation described in any one of the items in <8>.

[0087] <10> The mass ratio (C) / (B) of component (C) to component (B) is preferably 0.01 or higher, more preferably 0. 0.5 or higher, more preferably 0.10 or higher, even more preferably 0.20 or higher, and also preferably 10 More preferably 5 or less, even more preferably 1.5 or less, and even more preferably 0.8 or less <1>~ <9> A carbonated aerosol skin preparation described in any one of the items.

[0088] <11> The water content of component (D) in the aerosol concentrate is preferably 50% by mass or more. More preferably 60% by mass or more, even more preferably 70% by mass or more, and even more preferably 75% by mass or more It is above, and more preferably 98% by mass or less, more preferably 95% by mass or less, and even more preferably The mass is 90% or less, more preferably 85% or less. <1> ~ <10> One of the following items A carbonated aerosol skin preparation.

[0089] <12> Furthermore, the aerosol concentrate contains polyhydric alcohols. <1> ~ <11> any of A carbonated aerosol skin preparation as described in item 1.

[0090] <13> The polyhydric alcohol is preferably ethylene glycol, propylene glycol, and Ropanediol, 1,3-butylene glycol, 1,3-propanediol, dipropylene glycol Polyethylene glycol, polypropylene glycol, glycerin and sorbitol One or more types selected from the following, more preferable propylene glycol, propanediol, 1, 3-Butylene glycol, 1,3-propanediol, dipropylene glycol, and glycerin One or more selected from the following, more preferably 1,3-propanediol and dipropylene glycol. and one or more selected from glycerin, more preferably containing glycerin <12> As described Carbonated aerosol skin preparation.

[0091] <14> The polyhydric alcohol content in the aerosol concentrate is preferably 1% by mass or more. More preferably 2% by mass or more, even more preferably 5% by mass or more, and even more preferably 10% by mass The above applies, and more preferably 50% by mass or less, more preferably 40% by mass or less, even more preferably The amount is 30% by mass or less, and more preferably 20% by mass or less. <12> or <13> The carbonated Azole topical skin preparation.

[0092] <15> The mass ratio (E) / (A) of component (E) to component (A) is preferably 0.005 or more, more preferably 0 It is 0.10 or more, more preferably 0.2 or more, and also preferably 3000 or less, more preferably 30 It is 0 or less, more preferably 30 or less. <1> ~ <14> Carbonated aerosol as described in any one of the items A topical skin preparation.

[0093] <16> The ratio of component (E) to 100 parts by mass of the aerosol concentrate is preferably 0.01 parts by mass or more. More preferably 0.10 parts by mass or more, even more preferably 0.125 parts by mass or more, even more preferably 0.2 It is 5 parts by mass or more, more preferably 0.5 parts by mass or more, and even more preferably 1.0 part by mass or more. Preferably, the amount is 5.0 parts by mass or less, more preferably 3.0 parts by mass or less. <1> ~ <15> Noi A carbonated aerosol skin preparation as described in item 1.

[0094] <17> The pH immediately after discharge is preferably 7.0 or lower, more preferably 6.5 or lower, even more preferably The value is 6.0 or less, preferably 2.0 or more, more preferably 3.0 or more, and even more preferably It is 4.0 or higher. <1> ~ <16> A carbonated aerosol skin preparation described in any one of the items. [Examples]

[0095] Examples 1-51, Comparative Examples 1-5 Prepare the aerosol concentrate according to the formulations shown in Tables 1-8, and then pour the resulting composition into a pressure-resistant container (aerosol Fill a 100 mL glass test bottle and seal it, then pressurize component (E) to create an aerosol. We manufactured aerosol skin preparations. Regarding these carbonated aerosol skin preparations, the following methods and High-temperature storage stability was evaluated according to the specified standards.

[0096] <Method for evaluating high-temperature storage stability> After storing the aerosol compatibility bottle in a 45°C constant temperature bath for 30 days, and then returning it to 25°C, the following evaluation conditions were met. Appearance evaluation and dispensing performance were confirmed using the standard method. <Evaluation Criteria> A: No change, can be dispensed. B: Slightly thickens but remains fluid and can be dispensed. C: Thickens but remains fluid and can be dispensed. D: Fluidity decreases, but no precipitation occurs, and it can be dispensed. E: Dispensing impossible due to precipitation or gelation.

[0097] <Method for evaluating foam viscosity> A 20 mL plastic cup was filled to the brim with foam and measured using a viscometer VISCOMETER TVB10 (25 °C, rotor No. 3, 12 rpm, 10 s).

[0098] <Measurement of pH immediately after dispensing> Under 25°C conditions, the aerosol skin topical agent is dispensed from a pressure-resistant container into a 20 mL plastic cup. Approximately 5g was weighed out and dispensed, and the pH was measured using a pH meter (LAQUA F-74) after 1 minute.

[0099] <Method for evaluating moisturizing effect> When about 1 g of the aerosol topical skin preparation was discharged onto the inner part of the upper arm and spread with the palm, the moisturizing effect after application was evaluated by five professional panelists as very moist (2 points) / moist (1 point) / not moist (0 point). The total evaluation points were shown in a table.

[0100] <Evaluation method of spreadability> When about 1 g of the aerosol topical skin preparation was discharged onto the inner part of the upper arm and spread with the palm, the spreadability was evaluated by five professional panelists as easy to spread (2 points) / somewhat easy to spread (1 point) / difficult to spread (0 point). The total evaluation points were shown in a table.

[0101] <Evaluation method of sense of penetration> When about 1 g of the aerosol topical skin preparation was discharged onto the inner part of the upper arm and spread with the palm, the affinity of the preparation to the skin was evaluated by five professional panelists as easy to fit to the skin (2 points) / somewhat easy to fit to the skin (1 point) / difficult to fit to the skin (0 point). The total evaluation points were shown in a table.

[0102] <Evaluation method of sustained moisturizing effect on severely dry skin> Five professional panelists with dry shins washed their shins five times with soap, and then about 1 g of the aerosol topical skin preparation was discharged onto their shins and spread by hand. Then, the moist feeling of the shins after staying in a room at 20 °C and 40% humidity for 1 hour was evaluated as very moist (2 points) / moist (1 point) / not moist (0 point). The total evaluation points were shown in a table. After staying in a room at 20 °C and 40% humidity for one hour, the moist feeling of the shins was evaluated as very moist (2 points) / moist (1 point) / not moist (0 point). The total evaluation points were shown in a table. After staying in a room at 20 °C and 40% humidity for one hour, the moist feeling of the shins was evaluated as very moist (2 points) / moist (1 point) / not moist (0 point). The total evaluation points were shown in a table.

[0103] [Table 1]

[0104] [Table 2]

[0105]

Table 3

[0106]

Table 4

[0107]

Table 5

[0108]

Table 6

[0109]

Table 7

[0110]

Table 8

[0111] *1: Sphingolipid E (manufactured by Kao Corporation) *2: Nikkol SMT (manufactured by Nikko Chemicals Co., Ltd.) *3: Leodol TW-S120V (manufactured by Kao Corporation) *4: Leodol SP-S10V (manufactured by Kao Corporation) *5: Pemulen TR1 (manufactured by Lubrizol Advanced Materials) *6: Sanjelose 90L (manufactured by Daido Kasei Kogyo Co., Ltd.) *7: Carbopol 980 (manufactured by Lubrizol Advanced Materials) *8: Lipidure-PMB (manufactured by NOF Corporation) *9: Methocel 90SH15000 (manufactured by Shin-Etsu Chemical Co., Ltd.) *10: Keldent (manufactured by DSP Gokyo Food & Chemical Co., Ltd.) *11: Polymer KG30 (manufactured by Kao Corporation) *12: Phytosphingosine (manufactured by Evonik Nutrition & Care) *13: VARISOFT TA 100 (manufactured by Evonik Nutrition & Care) *14: NIKKOL Amidoamine MPB PLUS (manufactured by Nikko Chemicals Co., Ltd.) *15: Amisoft HS-11P (manufactured by Ajinomoto Co., Inc.) *16: COATSOME NC-21 (manufactured by NOF Corporation)

Claims

1. A carbonated aerosol skin preparation comprising an aerosol concentrate containing the following components (A) to (D) and a propellant containing component (E), The content of component (A) is 0.075 to 5.0% by mass. The mass ratio (A) / (B) of component (A) to component (B) is 0.2 or more and 15 or less. The mass ratio (A) / (C) of component (A) to component (C) is 0.01 or more and 40 or less. The mass ratio (C) / (B) of component (C) to component (B) is 0.20 or more and 0.8 or less. Carbonated aerosol skin preparation. (A) Ceramide lipids (B) Ionic surfactant selected from the following (B1) anionic surfactant, (B2) cationic surfactant, and (B3) amphoteric surfactant. (B1) Anionic surfactant comprising one or more selected from N-stearoyl glutamate sodium and N-stearoyl-N-methyl taurate sodium. (B2) Cationic surfactant comprising one or more selected from phytosphingosyl ammonium chloride, distearyldimethylammonium chloride, and behenamidopropyldimethylamine lactate. (B3) Amphoteric surfactant selected from hydrogenated soybean phospholipids (C) A water-soluble polymer containing one or more selected from hydroxypropyl methylcellulose, hydroxypropyl methylcellulose stearoyl ether, carboxyvinyl polymer, acrylic acid / (meth)acrylate alkyl copolymer, xanthan gum, N,N-dimethylaminoethyl methacrylate diethyl sulfate / N,N-dimethylacrylamide / polyethylene glycol dimethacrylate copolymer, and 2-methacryloyloxyethyl phosphorylcholine / butyl methacrylate copolymer. (D) Water (E) Carbon dioxide

2. The carbonated aerosol skin preparation according to claim 1, wherein the content of component (B) in the aerosol concentrate is 0.01% by mass or more and 5.0% by mass or less.

3. The carbonated aerosol skin preparation according to claim 1 or 2, wherein the content of component (C) in the aerosol concentrate is 0.010% by mass or more and 2.0% by mass or less.

4. A carbonated aerosol skin preparation according to any one of claims 1 to 3, wherein the content of component (D) in the aerosol concentrate is 75% by mass or more and 85% by mass or less.

5. Furthermore, the carbonated aerosol skin preparation according to any one of claims 1 to 4, wherein the aerosol concentrate contains a polyhydric alcohol.

6. A carbonated aerosol skin preparation according to any one of claims 1 to 5, wherein the mass ratio (E) / (A) of component (E) to component (A) is 0.25 or more and 30 or less.

7. A carbonated aerosol skin preparation according to any one of claims 1 to 6, wherein the ratio of component (E) to 100 parts by mass of the aerosol concentrate is 0.01 parts by mass or more and 5.0 parts by mass or less.

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