Blood purification device

Abstract

To simplify the priming process. [Solution] While the process of filling the blood purifier 120 with priming fluid 20 and the process of adjusting the liquid level of priming fluid 20 in the venous air trap chamber 114 are being carried out, the liquid level of priming fluid 20 in the arterial air trap chamber 112 decreases by a predetermined amount as the priming fluid 20 in the arterial air trap chamber 112 is drawn towards the blood purifier 120 according to the properties of the semipermeable membrane. In the process of adjusting the liquid level of priming fluid 20 in the arterial air trap chamber 112, the control unit adjusts the liquid level of priming fluid 20 to a first height obtained by adding the predetermined height to the target liquid level of priming fluid 20 in the arterial air trap chamber 112, based on parameter information showing the correlation between the above properties and the predetermined height.

Description

Technical Field

[0001] The present invention relates to a blood purification device.

Background Art

[0002] Conventionally, in a blood purification device, so-called priming is performed before it is used. Priming is a process of removing foreign substances and air in the circuit by introducing and filling a priming solution (generally physiological saline) into the blood circuit. As a document that discloses a blood purification device configured to automatically perform this priming, for example, there is Japanese Patent Application Laid-Open No. 2012-139405 (Patent Document 1).

[0003] In the blood purification device disclosed in Patent Document 1 above, first, the liquid level height of the priming solution in the arterial side air trap chamber is adjusted. Next, after this adjustment is completed, the entire blood purifier is filled with the priming solution. Next, after this filling is completed, the liquid level height of the priming solution in the venous side air trap chamber is adjusted.

Prior Art Documents

Patent Documents

[0004]

Patent Document 1

Summary of the Invention

Problems to be Solved by the Invention

[0005] Here, in the priming method as disclosed in Patent Document 1 above, even if the liquid level height of the priming solution in the arterial side air trap chamber is adjusted to the target height, during the filling of the priming solution into the entire blood purifier and the adjustment of the liquid level height of the priming solution in the venous side air trap chamber, which are performed after this, a phenomenon occurs in which the priming solution in the arterial side air trap chamber is drawn toward the blood purifier side.

[0006] The amount of priming fluid drawn towards the blood purifier depends on the properties of the semipermeable membrane installed in the blood purifier, such as its material and surface area. In other words, if the type of semipermeable membrane is changed, the amount of priming fluid drawn towards the blood purifier will also change.

[0007] Therefore, in medical settings, in order to adjust the liquid level of the priming fluid in the arterial air trap chamber to the target height, manual adjustment of this liquid level is sometimes performed after the automatic priming process described above, which results in a decrease in the efficiency of the priming process.

[0008] Therefore, the present invention has been made in view of the above-mentioned points, and aims to provide a blood purification device that simplifies priming. [Means for solving the problem]

[0009] The blood purification device according to the present invention comprises a blood purifier, an arterial blood circuit, a venous blood circuit, a blood pump, an arterial air trap chamber, a priming fluid line, an arterial supply and exhaust line, an arterial air valve, a venous air trap chamber, a venous on / off valve, a venous supply and exhaust line, a venous air valve, and a control unit. The blood purifier contains a semipermeable membrane inside. The arterial blood circuit is connected to the blood purifier and is for supplying blood to the blood purifier. The venous blood circuit is connected to the blood purifier and is for draining blood from the blood purifier. The blood pump is provided in the arterial blood circuit and pumps blood. The arterial air trap chamber is provided in the arterial blood circuit. The priming fluid line is connected to the arterial blood circuit upstream of the blood pump and supplies priming fluid. The arterial supply and exhaust line is connected to the arterial air trap chamber. The arterial air valve is provided in the arterial supply and exhaust pipeline and opens and closes the arterial supply and exhaust pipeline. The venous air trap chamber is provided in the venous blood circuit. The venous on / off valve is provided in the venous blood circuit and opens and closes the venous blood circuit. The venous supply and exhaust pipeline is connected to the venous air trap chamber. The venous air valve is provided in the venous supply and exhaust pipeline and opens and closes the venous supply and exhaust pipeline.

[0010] When priming the blood purifier, the arterial air trap chamber, and the venous air trap chamber, the control unit performs a step of adjusting the liquid level of the priming fluid in the arterial air trap chamber to a first height by operating the blood pump with the venous on-off valve and the venous air valve closed and the arterial air valve open. After adjusting the liquid level of the priming fluid in the arterial air trap chamber to the first height, the control unit performs a step of filling the entire blood purifier with the priming fluid by closing the arterial air valve and opening the venous on-off valve while keeping the venous air valve closed and the blood pump running. Furthermore, after filling the entire blood purifier with the priming fluid, the control unit performs a step of adjusting the liquid level of the priming fluid in the venous air trap chamber to a second height by closing the venous on-off valve and opening the venous air valve while keeping the arterial air valve closed and the blood pump running. While the steps of filling the entire blood purifier with the priming fluid and adjusting the liquid level of the priming fluid in the venous air trap chamber to the second height are being performed, the liquid level of the priming fluid in the arterial air trap chamber decreases by a predetermined amount as the priming fluid in the arterial air trap chamber is drawn toward the blood purifier due to the properties of the semipermeable membrane.

[0011] In the blood purification device according to the present invention described above, in the step of adjusting the liquid level of the priming fluid in the arterial side air trap chamber to the first height, the control unit adjusts the liquid level of the priming fluid in the arterial side air trap chamber to the first height, which is the sum of the target height of the liquid level of the priming fluid in the arterial side air trap chamber and the predetermined height, based on parameter information showing the correlation between the properties of the semipermeable membrane and the predetermined height. [Effects of the Invention]

[0012] According to the present invention, it is possible to provide a blood purification device in which priming is simplified. [Brief explanation of the drawing]

[0013] [Figure 1] This is a circuit diagram showing the configuration of a blood purification device according to an embodiment. [Figure 2] This is a block diagram showing the electrical connection relationships between the control unit and each component in a blood purification device according to an embodiment. [Figure 3] This is a flowchart illustrating the priming method in a blood purification device according to an embodiment. [Figure 4] Figure 3 is a circuit diagram representing step S2. [Figure 5] Figure 3 is a circuit diagram representing step S3. [Figure 6] Figure 3 is a circuit diagram representing step S4. [Modes for carrying out the invention]

[0014] Embodiments of the present invention will be described in detail below with reference to the drawings. In the embodiments described below, the same or common parts are denoted by the same reference numerals in the drawings, and their descriptions will not be repeated.

[0015] In the following description of embodiments, the blood purification device described will be a blood purification device used in Continuous Renal Replacement Therapy (CRRT). However, the blood purification device may be a blood purification device used in any of the following methods: hemodiafiltration (HDF), hemodialysis (HD), hemofiltration (HF), intermittent infusion hemodiafiltration (I-HDF), general hemodialysis (HD), continuous hemodiafiltration (CHDF), continuous hemofiltration (CHF), and continuous hemodialysis (CHD).

[0016] (Embodiment) Figure 1 is a circuit diagram showing the configuration of a blood purification device according to an embodiment. Figure 2 is a block diagram showing the electrical connection relationships between the control unit and each component in the blood purification device according to the embodiment. First, the configuration of the blood purification device 100 according to this embodiment will be described with reference to Figures 1 and 2.

[0017] As shown in Figures 1 and 2, the blood purification device 100 according to this embodiment includes a blood purifier 120, an arterial blood circuit 110, an arterial on-off valve 110v, a venous blood circuit 116, a venous on-off valve 116v, a blood pump 111, an arterial air trap chamber 112, an arterial supply and exhaust line 117, an arterial air valve 117v, a venous air trap chamber 114, a venous supply and exhaust line 118, a venous air valve 118v, a priming fluid supply source 190, a priming fluid line 191, a valve 191v, a control unit 1, a reading unit 210, and an input unit 220.

[0018] The blood purifier 120 contains, for example, a semipermeable membrane made of a hollow fiber membrane inside. The blood purifier 120 has a blood inlet 121 and a blood outlet 122. An arterial blood circuit 110 is connected to the blood inlet 121. A venous blood circuit 116 is connected to the blood outlet 122.

[0019] The arterial blood circuit 110 is provided with a blood pump 111 for pumping out blood and an arterial side on-off valve 110v for opening and closing the arterial blood circuit 110.

[0020] In the arterial blood circuit 110, an arterial air trap chamber 112 is provided between the blood pump 111 and the blood purifier 120. An arterial pressure measuring device 113 is provided in the arterial air trap chamber 112. The arterial pressure measuring device 113 measures the pressure in the arterial air trap chamber 112.

[0021] The blood collected from the patient's artery flows through the arterial blood circuit 110 and is measured for pressure when passing through the arterial air trap chamber 112, and then flows into the blood purifier 120 from the blood inlet 121. The arterial air trap chamber 112 is provided to prevent air from mixing into the blood in the arterial blood circuit 110.

[0022] An arterial protective filter 117f is provided between the arterial air trap chamber 112 and the arterial pressure measuring device 113. The arterial protective filter 117f has a function of preventing blood from flowing out of the blood circuit and a function of preventing infection from the pressure measuring device.

[0023] The arterial side supply and exhaust conduit 117 is connected to the arterial side air trap chamber 112 by being connected between the arterial side pressure measuring device 113 and the arterial side protective filter 117f. The arterial side supply and exhaust conduit 117 is provided with an arterial side air valve 117v for opening and closing the arterial side supply and exhaust conduit 117. The arterial side supply and exhaust conduit 117 is configured to be able to exhaust air from the arterial side air trap chamber 112 and to supply air into the arterial side air trap chamber 112.

[0024] A venous air trap chamber 114 is provided in the venous blood circuit 116. A venous pressure measuring device 115 is provided in the venous air trap chamber 114. The venous pressure measuring device 115 measures the pressure inside the venous air trap chamber 114.

[0025] After being purified by the blood purifier 120, the blood that flows out of the blood purifier 120 is returned to the patient's vein after its pressure is measured as it passes through the venous blood circuit 116 and the venous air trap chamber 114. The venous air trap chamber 114 is provided to prevent air from entering the blood in the venous blood circuit 116.

[0026] A venous protective filter 118f is provided between the venous air trap chamber 114 and the venous pressure measuring device 115. The venous protective filter 118f has the function of preventing blood from flowing out of the blood circuit and preventing infection from the pressure measuring device.

[0027] The venous blood circuit 116 is equipped with a venous on-off valve 116v that opens and closes the venous blood circuit 116. A bubble sensor 116s is integrated and attached to the venous on-off valve 116v. The bubble sensor 116s detects bubbles in the venous blood circuit 116. For example, an ultrasonic sensor can be used as the bubble sensor 116s. Note that the bubble sensor 116s is not necessarily attached to the venous on-off valve 116v.

[0028] The venous supply and exhaust line 118 is connected to the venous air trap chamber 114 by being connected between the venous pressure measuring device 115 and the venous protective filter 118f. The venous supply and exhaust line 118 is provided with a venous air valve 118v for opening and closing the venous supply and exhaust line 118. The venous supply and exhaust line 118 is configured to be able to exhaust air from the venous air trap chamber 114 and to supply air into the venous air trap chamber 114.

[0029] The blood purifier 120 further has a dialysate inlet 123 and a drain outlet 124. A dialysate line (not shown) is connected to the dialysate inlet 123. A drain line (not shown) is connected to the drain outlet 124.

[0030] A priming fluid line 191 is connected to the arterial blood circuit 110 at a position upstream of the blood pump 111. More specifically, the priming fluid line 191 is connected between the arterial on / off valve 110v and the blood pump 111 in the arterial blood circuit 110.

[0031] The priming fluid conduit 191 supplies the priming fluid 20 stored in the priming fluid supply source 190 to the arterial blood circuit 110, the blood purifier 120, and the venous blood circuit 116. The priming fluid conduit 191 is equipped with a valve 191v for opening and closing the priming fluid conduit 191. Physiological saline solution or the like is used as the priming fluid 20.

[0032] As shown in Figure 2, the control unit 1 is electrically connected to the blood pump 111, the arterial on / off valve 110v, the venous on / off valve 116v, the arterial air valve 117v, the venous air valve 118v, the valve 191v, the arterial pressure measuring device 113, the venous pressure measuring device 115, the bubble sensor 116s, the reading unit 210, and the input unit 220.

[0033] The control unit 1 receives the arterial pressure measurement value, which is the pressure inside the arterial air trap chamber 112 measured by the arterial pressure measuring device 113. The control unit 1 also receives the venous pressure measurement value, which is the pressure inside the venous air trap chamber 114 measured by the venous pressure measuring device 115. The control unit 1 also receives information transmitted from the bubble sensor 116s regarding the presence or absence of bubbles in the venous blood circuit 116.

[0034] The control unit 1 has as its main components a CPU (Central Processing Unit) 2, a memory 3, and input / output devices (not shown) for inputting and outputting various signals. The control unit 1 controls the operation of the blood pump 111, the arterial on / off valve 110v, the venous on / off valve 116v, the arterial air valve 117v, the venous air valve 118v, and the valve 191v.

[0035] CPU2 is responsible for executing programs. Memory3 includes ROM (Read Only Memory) and RAM (Random Access Memory). ROM stores data non-volatilely. RAM stores data generated by the execution of programs by CPU2 volatilely.

[0036] Each component of the control unit 1 is connected to the others by a data bus. Processing in the CPU 2 is realized by each piece of hardware and software executed by the CPU 2. Such software is pre-stored in the memory 3. The control unit 1 is powered by an internal power supply (not shown) or an external power supply (not shown). For connection to the external power supply, for example, an AC adapter (not shown) is used.

[0037] Memory 3 pre-stores a semipermeable membrane information table containing information about semipermeable membranes. The semipermeable membrane information table includes the material of the semipermeable membrane, the area of ​​the semipermeable membrane, and parameter information, associated with the type of semipermeable membrane, such as its model number. The parameter information shows the correlation between the material and area information as properties of the semipermeable membrane and the amount of priming fluid 20 drawn in from the arterial side air trap chamber 112 toward the blood purifier 120 during priming. In this embodiment, the liquid level height of the priming fluid 20 in the arterial side air trap chamber 112, corresponding to the amount of priming fluid 20 drawn in, is included as parameter information in the semipermeable membrane information table. The drawing in of the priming fluid 20 will be described in detail later.

[0038] The reading unit 210 is configured to read information about the semipermeable membrane contained inside the blood purifier 120. For example, a barcode reader can be used as the reading unit 210.

[0039] A two-dimensional barcode is printed on the semipermeable membrane itself or its packaging. The two-dimensional barcode contains information about the type of semipermeable membrane, such as a model number or identification number. The user of the blood purification device 100 (i.e., a medical professional, etc.) reads the two-dimensional barcode using the reader unit 210. The information about the semipermeable membrane obtained in this way is transmitted to the control unit 1.

[0040] The reading unit 210 is not limited to a barcode reader. For example, if the semipermeable membrane itself or its packaging material has a string of characters such as the semipermeable membrane's model number printed on it, the reading unit 210 may be configured to read these strings.

[0041] The input unit 220 is configured to accept input to the control unit 1 of information regarding the material and area of ​​the semipermeable membrane, and at least one of the above-mentioned parameter information. For example, an input device such as an operation panel can be used as the input unit 220. The operation panel has hard keys and / or software keys.

[0042] The user of the blood purification device 100 can input the above information about the semipermeable membrane into the memory 3 of the control unit 1 using the input unit 220. This makes it possible to add information about types of semipermeable membranes that are not pre-stored in the semipermeable membrane information table to the table.

[0043] Furthermore, the input unit 220 may be configured not only to add information about new types of semipermeable membranes to the semipermeable membrane information table as described above, but also to update existing information included in the semipermeable membrane information table.

[0044] In this case, if only information regarding the material and area of ​​a semipermeable membrane of a type not pre-stored in the semipermeable membrane information table is input to the control unit 1 (i.e., no parameter information is input), the control unit 1 may be configured to estimate the parameter information of the semipermeable membrane.

[0045] More specifically, the CPU2 of the control unit 1 may calculate estimated parameter information based on the input information and the information on each semipermeable membrane pre-stored in the semipermeable membrane information table. The CPU2 may also calculate estimated parameter information for the area of ​​the input semipermeable membrane based on the information on semipermeable membranes (more specifically, information on the area and parameter information of the semipermeable membrane) of the same material as the input semipermeable membrane, which is pre-stored in the semipermeable membrane information table. For this estimation, interpolation methods such as linear interpolation may be used.

[0046] Figure 3 is a flowchart illustrating the processing flow performed by the control unit during priming in the blood purification device according to this embodiment. Figures 4 to 6 are circuit diagrams showing each step shown in Figure 3. The priming method in the blood purification device 100 according to this embodiment will now be described with reference to Figures 3 to 6.

[0047] In this embodiment, the outlet portion of the venous blood circuit 116 may be placed, for example, in a separately provided drainage tank before each step of the priming method described below is carried out. In this case, the priming fluid 20 that passes downstream of the venous on-off valve 116v during the priming process described below is stored in this drainage tank.

[0048] As shown in Figure 3, when the blood purifier 120, arterial air trap chamber 112, and venous air trap chamber 114 are primed, first, in step S2 described later, the height H11, which is the liquid level height of the priming fluid 20 stored in the arterial air trap chamber 112, is determined (step S1).

[0049] In detail, first, the reading unit 210 reads information about the semipermeable membrane installed in the blood purifier 120 and transmits this information to the control unit 1. Next, based on the information obtained from the reading unit 210, the control unit 1 compares the type of semipermeable membrane installed in the blood purifier 120 with the types of semipermeable membranes included in the semipermeable membrane information table. Then, based on the parameter information corresponding to the type of semipermeable membrane determined by this comparison, the control unit 1 determines the height H11.

[0050] Furthermore, step S1 may be performed before priming begins. For example, step S1 may be performed when the semipermeable membrane is mounted on the blood purifier 120.

[0051] Next, as shown in Figures 3 and 4, the liquid level of the priming fluid 20 in the arterial air trap chamber 112 is adjusted to a height H11 (step S2).

[0052] In detail, the control unit 1 operates the blood pump 111 with valve 191v open, arterial air valve 117v open, arterial on / off valve 110v closed, venous on / off valve 116v closed, and venous air valve 118v closed. This adjusts the liquid level of the priming fluid 20 in the arterial air trap chamber 112 to a height H11. In this embodiment, height H11 corresponds to the first height.

[0053] Next, as shown in Figures 3 and 5, the entire blood purifier 120 is filled with priming fluid 20 (step S3).

[0054] In detail, the control unit 1 operates the blood pump 111 with valve 191v open, venous-side on / off valve 116v open, arterial-side on / off valve 110v closed, arterial-side air valve 117v closed, and venous-side air valve 118v closed. This fills the entire blood purifier 120 with priming fluid 20. Based on information transmitted from the bubble sensor 116s, the control unit 1 determines that the filling of the entire blood purifier 120 with priming fluid 20 is complete when it is determined that there are no bubbles in the venous-side blood circuit 116.

[0055] Furthermore, the liquid level H12 of the priming fluid 20 in the arterial air trap chamber 112 after the completion of step S3 is lower than the liquid level H11 of the priming fluid 20 in the arterial air trap chamber 112 after the completion of step S2.

[0056] Next, as shown in Figures 3 and 6, the liquid level of the priming fluid 20 in the venous air trap chamber 114 is adjusted to a height H2 (step S4).

[0057] In detail, the control unit 1 operates the blood pump 111 with valve 191v open, venous air valve 118v open, arterial on-off valve 110v closed, arterial air valve 117v closed, and venous on-off valve 116v closed. This adjusts the liquid level of the priming fluid 20 in the venous air trap chamber 114 to height H2. In this embodiment, height H2 corresponds to the second height.

[0058] Height H2 corresponds to the target liquid level of the priming fluid 20 that fills the venous air trap chamber 114 when priming is complete in the blood purification device 100. This target height is preset by the user before priming begins.

[0059] Furthermore, the liquid level H13 of the priming fluid 20 in the arterial air trap chamber 112 after the completion of step S4 is lower than the liquid level H12 of the priming fluid 20 in the arterial air trap chamber 112 after the completion of step S3.

[0060] Height H13 corresponds to the target liquid level of the priming fluid 20 that fills the arterial air trap chamber 112 when priming is complete in the blood purification device 100. This target height is preset by the user before priming begins.

[0061] By going through the steps S1 to S4 described above, the priming of the blood purifier 120, arterial air trap chamber 112, and venous air trap chamber 114 in the blood purification device 100 is completed.

[0062] Here, as shown in Figures 4 to 6, while steps S3 and S4 described above are being carried out, the liquid level of the priming fluid 20 in the arterial side air trap chamber 112 decreases by a predetermined height ΔH as the priming fluid 20 in the arterial side air trap chamber 112 is drawn toward the blood purifier 120 side.

[0063] Therefore, as described above, the height H12 of the priming fluid 20 in the arterial air trap chamber 112 shown in Figure 5 is lower than the height H11 of the priming fluid 20 in the arterial air trap chamber 112 shown in Figure 4. Also, the height H13 of the priming fluid 20 in the arterial air trap chamber 112 shown in Figure 6 is lower than the height H12 of the priming fluid 20 in the arterial air trap chamber 112 shown in Figure 5.

[0064] Thus, the amount of priming fluid 20 drawn from the arterial air trap chamber 112 toward the blood purifier 120 is determined according to the material and area of ​​the semipermeable membrane installed in the blood purifier 120. In other words, the predetermined height ΔH obtained by subtracting height H13 from height H11 is determined according to the material and area of ​​the semipermeable membrane.

[0065] In this regard, in the blood purification device 100 according to this embodiment, the control unit 1, in the process of adjusting the liquid level of the priming fluid 20 in the arterial side air trap chamber 112 to a height H11, adjusts the liquid level of the priming fluid 20 in the arterial side air trap chamber 112 to a height H11, based on parameter information showing the correlation between the material of the semipermeable membrane, the area of ​​the semipermeable membrane, and a predetermined height ΔH, so that the liquid level of the priming fluid 20 in the arterial side air trap chamber 112 becomes a height H11, which is the sum of the target height H13 and the predetermined height ΔH.

[0066] As a result, in step S4, the liquid level of the priming fluid 20 in the arterial air trap chamber 112 is adjusted to the target level when priming in the blood purification device 100 is completed. Therefore, after step S4, it becomes unnecessary for the user to manually readjust this liquid level.

[0067] Therefore, by configuring it as described above, it becomes possible to create a blood purification device 100 in which priming is simplified.

[0068] In the embodiment described above, an example was given in which information can be added to and / or updated in the semipermeable membrane information table stored in memory 3 via the input unit 220. However, the blood purification device 100 may be configured to remotely manage (add and / or update) the semipermeable membrane information table.

[0069] (Note) The characteristic configuration of the blood purification device disclosed in the above-described embodiment can be summarized as follows:

[0070] [Note 1] A blood purifier containing a semipermeable membrane inside, An arterial blood circuit connected to the above-mentioned blood purifier for supplying blood to the above-mentioned blood purifier, A venous blood circuit connected to the above-mentioned blood purifier, for draining blood from the above-mentioned blood purifier, A blood pump is provided in the arterial blood circuit mentioned above to pump out blood, The arterial side air trap chamber provided in the arterial side blood circuit, A priming fluid conduit, which supplies priming fluid, is connected to the arterial blood circuit at a position upstream of the blood pump mentioned above, The arterial side supply and exhaust line connected to the arterial side air trap chamber, An arterial side air valve is provided in the arterial side supply and exhaust pipeline and opens and closes the arterial side supply and exhaust pipeline, A venous air trap chamber is provided in the venous blood circuit described above, A venous on / off valve is provided in the venous blood circuit described above, which opens and closes the venous blood circuit, The venous supply and exhaust piping connected to the venous air trap chamber mentioned above, A venous air valve is provided in the venous supply and exhaust pipeline and opens and closes the venous supply and exhaust pipeline, It includes a control unit, When priming the blood purifier, the arterial air trap chamber, and the venous air trap chamber, the control unit shall The blood pump is operated with the venous side on / off valve and the venous side air valve closed and the arterial side air valve open, thereby adjusting the liquid level of the priming fluid in the arterial side air trap chamber to a first height. After adjusting the liquid level of the priming fluid in the arterial air trap chamber to the first height, the venous air valve is closed and the blood pump is kept running, while the arterial air valve is closed and the venous on / off valve is opened, thereby filling the entire blood purifier with the priming fluid. After filling the entire blood purifier with the priming fluid, the arterial air valve is closed and the blood pump is kept running, while the venous on / off valve is closed and the venous air valve is opened, thereby adjusting the liquid level of the priming fluid in the venous air trap chamber to a second height. While the steps of filling the entire blood purifier with the priming fluid and adjusting the liquid level of the priming fluid in the venous air trap chamber to the second height are being performed, the liquid level of the priming fluid in the arterial air trap chamber decreases by a predetermined height as the priming fluid in the arterial air trap chamber is drawn toward the blood purifier due to the properties of the semipermeable membrane. In the process of adjusting the liquid level of the priming fluid in the arterial-side air trap chamber to the first height, the control unit adjusts the liquid level of the priming fluid in the arterial-side air trap chamber to the first height, which is the sum of the target height of the liquid level of the priming fluid in the arterial-side air trap chamber and the predetermined height, based on parameter information showing the correlation between the properties of the semipermeable membrane and the predetermined height.

[0071] [Note 2] The above properties of the semipermeable membrane are the material of the semipermeable membrane and the area of ​​the semipermeable membrane, as described in Appendix 1 of the blood purification apparatus.

[0072] [Note 3] The blood purification apparatus according to Appendix 1 or 2, further comprising a reading unit capable of reading information regarding the above-mentioned properties of the semipermeable membrane.

[0073] [Note 4] The blood purification device according to any one of the appendices 1 to 3, further comprising an input unit capable of inputting at least one of the information relating to the properties of the semipermeable membrane and the parameter information into the control unit.

[0074] (Other forms, etc.) The shape, configuration, size, number, material, etc., of each part shown in the embodiments of the present invention described above can be modified in various ways without departing from the spirit of the present invention.

[0075] Furthermore, the characteristic configurations shown in the embodiments of the present invention described above can naturally be combined with each other to the extent permitted in light of the spirit of the present invention.

[0076] Thus, the embodiments disclosed herein are illustrative in all respects and not restrictive. The technical scope of the present invention is defined by the claims and includes all modifications within the meaning and scope of equivalents to the claims. [Explanation of Symbols]

[0077] 1 Control unit, 2 CPU, 3 Memory, 20 Priming fluid, 100 Blood purification device, 110 Arterial blood circuit, 110v Arterial on / off valve, 111 Blood pump, 112 Arterial air trap chamber, 113 Arterial pressure measuring device, 114 Venous air trap chamber, 115 Venous pressure measuring device, 116 Venous blood circuit, 116s Bubble sensor, 116v Venous on / off valve, 117 Arterial supply / exhaust line, 117f Arterial protective filter, 117v Arterial air valve, 118 Venous supply / exhaust line, 118f Venous protective filter, 118v Venous air valve, 120 Blood purifier, 121 Blood inlet, 122 Blood outlet, 123 Dialysis fluid inlet, 124 Drain outlet, 190 Priming fluid supply source, 191 Priming fluid line, 191v Valve, 210 reading section, 220 input section.

Claims

1. A blood purifier containing a semipermeable membrane inside, An arterial blood circuit connected to the blood purifier for supplying blood to the blood purifier, A venous blood circuit connected to the blood purifier for draining blood from the blood purifier, A blood pump is provided in the arterial blood circuit to pump blood, An arterial side air trap chamber provided in the arterial side blood circuit, A priming fluid conduit, which supplies priming fluid, is connected to the arterial blood circuit at a position upstream of the blood pump, The arterial side supply and exhaust pipe connected to the arterial side air trap chamber, An arterial side air valve is provided in the arterial side supply and exhaust pipeline and opens and closes the arterial side supply and exhaust pipeline, A venous air trap chamber provided in the venous blood circuit, A venous on / off valve is provided in the venous blood circuit and opens and closes the venous blood circuit, A venous supply and exhaust pipe connected to the venous air trap chamber, A venous air valve is provided in the venous supply and exhaust pipeline and opens and closes the venous supply and exhaust pipeline, It includes a control unit, When priming the blood purifier, the arterial air trap chamber, and the venous air trap chamber, the control unit, The blood pump is operated with the venous side on / off valve and the venous side air valve closed and the arterial side air valve open, thereby adjusting the liquid level of the priming fluid in the arterial side air trap chamber to a first height. After the step of adjusting the liquid level of the priming fluid in the arterial air trap chamber to the first height, the step of filling the entire blood purifier is performed by closing the arterial air valve and opening the venous on / off valve while the venous air valve is closed and the blood pump is running, After the step of filling the entire blood purifier with the priming fluid, the step of closing the arterial air valve and keeping the blood pump running, and closing the venous on / off valve and opening the venous air valve is performed to adjust the liquid level of the priming fluid in the venous air trap chamber to a second height. While the steps of filling the entire blood purifier with the priming fluid and adjusting the liquid level of the priming fluid in the venous air trap chamber to the second height are being performed, the liquid level of the priming fluid in the arterial air trap chamber decreases by a predetermined height as the priming fluid in the arterial air trap chamber is drawn toward the blood purifier side according to the properties of the semipermeable membrane. In the step of adjusting the liquid level of the priming fluid in the arterial-side air trap chamber to a first height, the control unit adjusts the liquid level of the priming fluid in the arterial-side air trap chamber to a first height, based on parameter information indicating the correlation between the properties of the semipermeable membrane and the predetermined height, so that the liquid level of the priming fluid in the arterial-side air trap chamber becomes the first height, which is the sum of the target height of the liquid level of the priming fluid in the arterial-side air trap chamber and the predetermined height, in a blood purification device.

2. The blood purification apparatus according to claim 1, wherein the properties of the semipermeable membrane are the material of the semipermeable membrane and the area of ​​the semipermeable membrane.

3. The blood purification apparatus according to claim 1, further comprising a reading unit capable of reading information relating to the properties of the semipermeable membrane.

4. The blood purification apparatus according to claim 1, further comprising an input unit capable of inputting at least one of the following to the control unit: information relating to the properties of the semipermeable membrane and the parameter information.

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