Elastin formation using fiber implants
Patent Information
- Authority / Receiving Office
- JP · JP
- Patent Type
- Applications
- Current Assignee / Owner
- STENTIT BV
- Filing Date
- 2026-02-02
- Publication Date
- 2026-06-09
Smart Images
Figure 2026094141000001 
Figure 2026094141000002 
Figure 2026094141000003
Abstract
Claims
1. A cardiovascular fiber implant for reconstructing elastin, The implant is composed of fibers that form a network, The fibers included in the network are characterized by having a fiber diameter of 150 μm or less. Cardiovascular fiber implants.
2. The fiber implant described in claim 1 is at least partially bioabsorbable. Vascular implant.
3. The fiber implant comprises a drug and / or an adhesive component, as described in claim 1 or 2. Fiber implants.
4. A claim is made in which a fiber is covered with a coating layer, the coating layer containing a drug and / or adhesive component. A fiber implant as described in any one of items 1 to 3.
5. The aforementioned fiber implant facilitates cell adhesion, migration, invasion, proliferation, differentiation (transformation), and tissue synthesis. Claims 1 to 4 include fibers and / or pores that enable the composition and combination thereof. A fiber implant as described in any one of the items.
6. The fiber implant is composed of multiple fiber layers, and the multiple fiber layers are at least It also includes a first fiber layer and a second fiber layer, wherein the first fiber layer is separated from the second fiber layer. A fiber implant according to any one of claims 1 to 5, as specified separately.
7. The first fiber layer has fiber diameter, pore size, density, stiffness, fiber structure, material composition, drug composition, and adhesive properties. In a parameter selected from the group consisting of minutes, resolution rate, and combinations thereof, The fiber implant according to claim 6, which is distinguishable from two fiber layers.
8. The aforementioned fiber implant i) Planar shape; ii) Tube shape The tube shape is a. Valves used as valve prostheses, b. Membranes, emboluses, or other materials used as occlusion devices, embolization devices, or blockage devices. Swelling ingredients A fiber implant according to any one of claims 1 to 7, which optionally includes the following:
9. The aforementioned fiber implant reconstructs the smooth muscle layer and / or endothelial layer in addition to elastin. By doing so, the media and / or intima of the blood vessels can be reconstructed, at least partially. A fiber implant according to any one of claims 1 to 8, which can perform the following:
10. Use of a fiber implant according to claim 8, wherein the fiber implant has a planar shape However, it is used as a patch.
11. The use of the fiber implant according to claim 8, wherein the tubular fiber implant is , scaffold, stent, covered stent, stent graft, graft, bypass Used as a graft, fistula, or shunt.
12. The following combinations for transplantation into a host, as described in any one of claims 1 to 9 The use of the fiber implant shown, The fiber implant, at least partially i) Direct contact with blood flow, and / or ii) Healthy native tissue, injured native tissue, damaged native tissue, affected native tissue Direct contact with native organizations selected from groups consisting of organizations and combinations thereof. ： However, the use described above does not include the introduction of the fiber implant into the host.
13. Claim 1, the fiber implant is attached to an additional support or delivery device. Use as described in 2.
14. The fiber implant in use is exposed to a mechanical load, and the mechanical load is static. A mechanical load state and / or a dynamic load state, wherein the mechanical load state is shear Selected from the group consisting of force, pre-stress, pre-strain, residual stress, extension, compression, and combinations thereof. The use according to claim 12 or 13.
15. Cardiovascular fiber in for reconstructing elastin, according to any one of claims 1 to 9 Plant use.