solid components

Abstract

In a composition containing vitamin B12 and specific vitamins, the time-dependent distribution of vitamins To provide a solid composition that can suppress dissolution and has excellent storage stability. [Solution] (A) Vitamin B1, vitamin B2, vitamin B6, and ascorbic acid or the same It contains at least one selected from salts, (B) vitamin B12, and (C) taurine. A solid composition characterized by the following.

Description

Technical Field

[0001] The present invention relates to a stable composition in a vitamin-containing composition in which a decrease in the content of vitamins is suppressed.

Background Art

[0002] Currently, pharmaceuticals, quasi-drugs, health foods, etc. containing multiple vitamins are commercially available. These contain different vitamins etc. according to the purpose, and it is extremely useful in that it is possible to ingest the necessary active ingredients more simply than taking each of multiple types of pharmaceuticals, quasi-drugs, health foods, etc. individually.

[0003] In formulating a pharmaceutical composition, the component stability of the formulation components is very important. After the formulation components are formulated, if they become unstable over time under various environmental conditions (for example, under high temperature, low temperature, exposure to light, humid environment, etc.) and their content significantly decreases, there is concern that the component may not exhibit the intended effect. In particular, a higher level of formulation stability is required for pharmaceutical compositions in which the dosage of the formulation components should be strictly controlled.

[0004] Water-soluble vitamins are generally known to be unstable under the influence of environmental factors such as heat and light, and are likely to cause a decrease in content.

[0005] Vitamin B1 promotes carbohydrate metabolism and has the effect of maintaining the normal functions of nerves and muscles, and is known to be effective for fatigue recovery and stress relief (Patent Document 1).

[0006] Vitamin B2 is a component of a nutritional supplement when intake from diet is insufficient, such as in wasting diseases. ​​​​​​​​​​​Furthermore, conditions such as angular cheilitis, cheilitis, acute and chronic eczema, and conjunctivitis are caused by vitamin B2 deficiency or metabolic disorders. It is used as an ingredient in preventive and therapeutic agents for diseases in which harm is suspected to be involved. (Patent Document 2) )

[0007] Furthermore, vitamin B6 acts as a coenzyme for amino acid decarboxylase and aminotransferase in the body. It is a component involved in protein metabolism and is used for physical fatigue, eye strain, and nutritional supplementation during pregnancy. Therefore, it is widely used in pharmaceuticals, hair growth products, health foods, etc. (Patent Document 3).

[0008] Vitamin B12 is involved in many metabolic pathways in the body, and plays a role in normal development, hematopoiesis, and nerve tissue formation. It plays an important role in processes such as lien sheath formation. It also has pharmacological effects such as improving eye strain and fatigue. It is known to have various uses and is often included in multivitamins and eye drops.

[0009] However, these vitamins B1, B2, B6 and B It is widely known that vitamin B group vitamins, such as those in category 12, have many stability issues. Various methods are being considered to stabilize the B vitamins. For example, vitamin B1 When combined with tocopherol succinate, one of them should be coated with a coating agent. Methods to stabilize the product include using starch and calcium hydrogen phosphate along with vitamin B1. A method is disclosed that can suppress the time-dependent degradation of vitamin B1 by incorporating calcium. (Patent Documents 4 and 5)

[0010] Furthermore, ascorbic acid or its salts are water-soluble vitamins and are unstable to heat and light. It is widely known that methods for stabilizing ascorbic acid or its salts are available. Various studies have been conducted. For example, a method of stabilizing by coating the periphery of ascorbic acid with a hydrophobic heat-melting lipid has been disclosed (Patent Document 6). However, in the conventional method, there are restrictions on formulation and formulation design, so there are many cases where it cannot be applied.

[0011] However, in the conventional method, there are restrictions on formulation and formulation design, so there are many cases where it cannot be applied. Many.

Prior Art Documents

Patent Documents

[0012]

Patent Document 1

Patent Document 2

Patent Document 3

Patent Document 4

Patent Document 5

Patent Document 6

[0015] In other words, the present invention is (1) (A) Vitamin B1, vitamin B2, vitamin B6, and ascorbic acid or (B) vitamin B12 and (C) taurine are selected from the salt. A solid composition characterized by containing, (2) Furthermore, the (D) The (1) description containing low-substituted hydroxypropyl cellulose solid composition, (3)(A) Vitamin B1 is thiamine or a salt thereof, as described in (1) or (2) solid composition, (4)(A) Vitamin B2 is riboflavin or a salt thereof, (1)~(3) A solid composition as described in any of the following: (5)(A) Vitamin B6 is pyridoxine or a salt thereof, (1)~(4) A solid composition as described in any of the following: (6)(B) Vitamin B12 is cyanocobalamin or mecobalamin, (1)~ (5) A solid composition according to any one of the following: (7)(C) Taurine is synthetic taurine or taurine derived from marine products, (1)~(6) A solid composition according to any of the following: (8)(C) Taurine is 30 to 90% by mass of the total mass of the composition, (1) to (7 A solid composition as described in any of the following: (9) A tablet, granule, powder or capsule, as described in any of (1) to (8) Formation composition, That is the case. [Effects of the Invention]

[0016] This invention makes it possible to provide a solid composition in which the decrease in vitamin content is suppressed. [Modes for carrying out the invention]

[0017] In this invention, "vitamin B1" means vitamin B1 or its derivatives or These are salts of thiamine itself, as well as its derivatives (bisthiamine, thiamine disulfide). Id, Dicethiamine, Fursultiamine, Octothiamine, Shikotiamine, Bisibthia mine, bisbentiamine, prosultiamine, benfotiamine, thiamine diphosphate, etc. ) and their salts (such as inorganic salts like nitrates, hydrochlorides, and sulfates) are also included, and these are It can be used alone or in combination of two or more types. Among these, the present invention These include thiamine hydrochloride, thiamine nitrate (thiamine nitrate), bisthiamine nitrate, and thiamine. Disulfide, thiamine dicetyl sulfate, dicethiamine hydrochloride, fursultia hydrochloride Min, Octothiamine, Shikotiamine, Bisibthiamine, Bisbentiamine, Fursul Thiamine, prosultiamine, and benfotiamine are preferred, and thiamine nitrate (thiamine nitrate) (modified), fursultiamine hydrochloride, benfotiamine is more preferred, fursultiamine hydrochloride More preferably, thiamine nitrate (thiamine nitrate) ) is particularly preferred. These vitamin B1 compounds are known compounds, and commercially available ones can be used. It is also possible to manufacture it by known methods.

[0018] The ratio of vitamin B1 compounds to taurine in this invention affects the stability of vitamin B1 compounds. From vitamin B1 (total amount if multiple vitamin B1 types are included; the same applies hereinafter), 1 quality The amount of taurine is preferably 4 to 300 parts by mass, and more preferably 20 to 200 parts by mass, relative to the total amount. More preferably 20 to 150 parts by mass, and particularly preferably 20 to 100 parts by mass.

[0019] The ratio of vitamin B1 compounds to low-substituted hydroxypropyl cellulose in this invention is: Due to the effect of the stability of vitamin B1, 1 part by mass of vitamin B1 is used. The amount of silpropylcellulose is preferably 0.5 to 50 parts by mass, and more preferably 1 to 20 parts by mass. , 1 to 10 parts by mass is more preferable, and 2 to 10 parts by mass is particularly preferable.

[0020] The daily intake of vitamin B1 compounds in this invention is not particularly limited, and the use of the composition is also limited. It can be adjusted as appropriate depending on the purpose, etc. For example, in the case of a composition for oral administration, per day, Vitamin B1 compounds are preferably 0.1 to 300 mg, more preferably 1 to 100 mg, and 1 to 2 5 mg is even more preferable.

[0021] In the composition of the present invention, from the viewpoint of being able to sufficiently maintain the stability of the composition, vitamin It is preferable that the amount of compound B1 is 0.01 to 30% by mass relative to the total mass of the composition. It is more preferable to contain 0.1 to 20% by mass, and more preferable to contain 0.1 to 10% by mass. More preferably, it is particularly preferable to include 0.8 to 5 parts by mass.

[0022] In this invention, "vitamin B2s" means vitamin B2 or its derivatives or These are salts, and in addition to riboflavin itself, its derivatives (riboflavin phosphate, riboflavin butyrate) are also included. (e.g., boflavin, flavin adenine dinucleotide) and their salts (e.g., sodium salts) This also includes alkali metal salts, etc., and in the present invention, these are used individually or in combination of two or more. These can be used in combination. Among these, in the present invention, flavinade Ginseng dinucleotide sodium, riboflavin, riboflavin phosphate sodium, butyrate ri Boflavin is preferred, and riboflavin is particularly preferred. These vitamin B2 derivatives are known It is a compound, and commercially available products may be used, or it can be manufactured by known methods. That is the case.

[0023] The ratio of vitamin B2 compounds to taurine in this invention affects the stability of vitamin B2 compounds. From vitamin B2 (the total amount if multiple vitamin B2 types are included; the same applies hereinafter), 1 quality The amount of taurine is preferably 4 to 750 parts by mass, and more preferably 20 to 500 parts by mass, relative to the total amount. Furthermore, 20 to 300 parts by mass is more preferable, and 40 to 250 parts by mass is particularly preferable.

[0024] In the present invention, the ratio of vitamin B2 compounds to low-substituted hydroxypropyl cellulose is In this regard, due to the effect of the stability of vitamin B2, a low degree of substitution is used for 1 part by mass of vitamin B2. Hydroxypropyl cellulose is preferably 0.5 to 50 parts by mass, and 1 to 40 parts by mass is more Preferably, 1 to 50 parts by mass is preferred, more preferably 8 to 50 parts by mass is preferred.

[0025] The daily intake of vitamin B2 compounds in this invention is not particularly limited, and the use of the composition is also limited. It can be adjusted as appropriate depending on the purpose, etc. For example, in the case of a composition for oral administration, per day, Vitamin B2 is preferably 0.1 to 100 mg, more preferably 0.5 to 45 mg, and 1 to 45 mg is more preferred, and 2 to 15 mg is particularly preferred.

[0026] In the present invention, from the viewpoint of being able to sufficiently maintain the stability of the composition, vitamin B2 It is preferable that it be contained in an amount of 0.01 to 30% by mass relative to the total mass of the composition, and 0.01 to It is more preferable to contain 20% by mass, and even more preferable to contain 0.05 to 10% by mass. Preferably, it contains 0.1 to 2.5% by mass.

[0027] In the present invention, "vitamin B6 derivatives" means vitamin B6 or its derivatives or These are salts, and include pyridoxine, pyridoxamine, pyridoxal itself, as well as those Derivatives of (such as pyridoxal phosphate) and their salts (such as alkaline earth minerals like calcium salts) This also includes metal salts (such as inorganic salts like hydrochlorides), and in the present invention, these are used individually. or two or more can be used in combination. Among these, in the present invention Pyridoxine hydrochloride and pyridoxal phosphate are preferred, and pyridoxine hydrochloride is particularly preferred. These vitamin B6 compounds are well-known compounds, and commercially available ones can be used. Furthermore, it can also be manufactured by known methods.

[0028] The ratio of vitamin B6 compounds to taurine in this invention affects the stability of vitamin B6 compounds. From vitamin B6 (total amount if multiple vitamin B6 types are included; the same applies hereinafter), 1 quality The amount of taurine is preferably 4 to 750 parts by mass, and more preferably 20 to 400 parts by mass, relative to the total amount. More preferably 20 to 250 parts by mass, and particularly preferably 25 to 250 parts by mass.

[0029] In the present invention, the ratio of vitamin B6 compounds to low-substituted hydroxypropyl cellulose is In this regard, due to the effect of the stability of vitamin B6, a low degree of substitution is used for 1 part by mass of vitamin B6. Hydroxypropyl cellulose is preferably 0.5 to 50 parts by mass, and 1 to 50 parts by mass is more Preferably, 10 to 50 parts by mass is more preferable.

[0030] The daily intake of vitamin B6 compounds in this invention is not particularly limited, and the use of the composition is also limited. It can be adjusted as appropriate depending on the purpose, etc. For example, in the case of a composition for oral administration, per day, Vitamin B6 compounds are preferably 0.1 to 100 mg, more preferably 0.5 to 50 mg, and 1 to 50 mg is more preferred, and 1 to 10 mg is particularly preferred.

[0031] In the present invention, from the viewpoint of being able to sufficiently maintain the stability of the composition, vitamin B6 It is preferable that it be contained in an amount of 0.01 to 30% by mass relative to the total mass of the composition, and 0.1 to 2% by mass. It is more preferable to contain 0% by mass, and even more preferable to contain 0.1 to 10% by mass. A concentration of 0.3 to 1.8% by mass is particularly preferred.

[0032] In this invention, "ascorbic acid or its salt" means ascorbic acid itself, as well as , their salts (alkaline earth metal salts such as calcium salts; alkali metal salts such as sodium salts) This also includes group salts, and in the present invention, these are used individually or in combination of two or more. It can be used as follows. Among these, in the present invention, ascorbic acid, ascorbic acid Calcium ascorbate is preferred, and calcium ascorbate is particularly preferred. These as Corbic acid or its salts are known compounds, and commercially available ones may be used, as well as known It is also possible to manufacture it using certain methods.

[0033] The ratio of ascorbic acid or its salt to taurine in this invention is ascorbic acid or Due to the stability effect of the salt, ascorbic acid or its salts (multiple ascorbic acids or their salts) If it includes, the total amount. (The same applies below), taurine is 0.2 to 30 parts by mass per 1 part by mass. Preferably, 0.3 to 20 parts by mass, more preferably 1 to 15 parts by mass, and 1 ~10 parts by mass is particularly preferred.

[0034] In the present invention, ascorbic acid or a salt thereof and low-substituted hydroxypropyl cellulose In the blending ratio, due to the effect of the stability of ascorbic acid or its salt, ascorbic acid or For every 1 part by mass of the salt, 0.1 to 40 parts by mass of low-substituted hydroxypropyl cellulose are used. Preferably, 0.1 to 30 parts by mass, more preferably 0.1 to 10 parts by mass A value between 0.2 and 2.5 is particularly preferred.

[0035] The daily intake of ascorbic acid or its salt in this invention is not particularly limited, and the combination The composition can be adjusted as appropriate depending on the intended use of the product. For example, in the case of a composition for oral administration, 1 The amount of ascorbic acid or its salt per day is preferably 1 to 2,000 mg, and 10 to 1,000 m g is more preferable, and 50-700 mg is even more preferable.

[0036] In the present invention, from the viewpoint of being able to sufficiently maintain the stability of the composition, ascorbic acid Alternatively, the salt is preferably contained in an amount of 1 to 60% by mass relative to the total mass of the composition, and 5 to 6 It is more preferable to contain 0% by mass, and even more preferable to contain 5-50% by mass. stomach.

[0037] In the present invention, "vitamin B12s" means vitamin B12 or its derivatives or These are salts, including cyanocobalamin and hydroxocobalamin themselves, as well as their salts. Derivatives (mecobalamin, deoxyadenosylcobalamin, etc.) and their salts (hydrochloride salts, etc.) This includes any inorganic salt (such as an organic salt like an acetate), and in this invention, these are simply They can be used individually or in combination of two or more types. Vitamin B12 compounds are common to all of the following: It has a choline ring structure containing cobalt at the center of the molecule. In this invention, hydrochloride Xosocobalamin, hydroxocobalamin acetate, cyanocobalamin, mecobalamin, hydro Kisocobalamin is preferred, cyanocobalamin and mecobalamin are more preferred, and cyanoco Balamin is particularly preferred. These vitamin B12 compounds are known compounds and commercially available... It may be manufactured using [a specific method], or it may be manufactured by a known method.

[0038] The ratio of vitamin B12 compounds to taurine in this invention is determined by the stability of vitamin B12 compounds. Based on the effects, vitamin B12 (the total amount if multiple vitamin B12 types are included; the same applies below) ), preferably 30 to 150,000 parts by mass of taurine per 1 part by mass, and 100 to 15 0,000 parts by mass is more preferable, 2,500 to 50,000 parts by mass is even more preferable, and 5, A concentration of 000 to 25,000 parts by mass is particularly preferred.

[0039] The ratio of vitamin B12 compounds to low-substituted hydroxypropyl cellulose in this invention is Due to the effect of the stability of vitamin B12, 1 part by mass of vitamin B12 is used. The amount of droxypropyl cellulose is preferably 0.2 to 20,000 parts by mass, and preferably 0.6 to 15,0 00 parts by mass is more preferable, 15 to 5,000 parts by mass is even more preferable, and 500 to 5,0 A mass of 00 parts is particularly preferred.

[0040] The daily intake of vitamin B12 compounds in this invention is not particularly limited, and the composition is useful. It can be adjusted as appropriate depending on the purpose of use, etc. For example, in the case of a composition for oral administration, per day Vitamin B12 compounds are preferably present in amounts of 1 to 5,000 μg, and more preferably in amounts of 1 to 1,500 μg. 1 to 60 μg is even more preferable.

[0041] In the present invention, from the viewpoint of being able to sufficiently maintain the stability of the composition, vitamin B12 The amount of this component is preferably 0.0001 to 5% by mass relative to the total mass of the composition, and 0.0 It is more preferable to contain 0.01 to 1.5% by mass, and more preferable to contain 0.001 to 0.06% by mass. It is even preferable to tighten it.

[0042] The taurine used in this invention is taurine that conforms to the Japanese Pharmacopoeia or food additives. , synthetic taurine, or extracts from marine products such as squid, octopus, and oysters that contain taurine (water Examples include product-derived extracts. Preferably, synthetic taurine (synthetic product), and This refers to taurine derived from marine products, more preferably synthetic taurine. Furthermore, taurine derived from bovine bile... Taurine is undesirable. Taurine can be produced by known methods, or commercially available taurine can be used. It is possible.

[0043] In this invention, taurine is contained in an amount of 20 to 98% by mass relative to the total mass of the composition. Preferably, it is contained in 30-98% by mass, more preferably in 40-96% by mass. It would be even better if...

[0044] The low-substituted hydroxypropyl cellulose used in the present invention has a very small amount of cellulose in its cellulose backbone. It is a cellulose having a certain amount of hydroxypropoxy groups, and from the viewpoint of producing a solid composition, Preferably, the hydroxypropoxy group content is 5 to 16% by mass. More preferably, the hydroxypropoxy group content is 7 to 14% by mass, and hydroxypropoxy A more preferable option is one in which the base content is 8 to 11% by mass. It is not particularly limited. However, low-substituted hydroxypropyl cellulose conforming to the Japanese Pharmacopoeia or food additives is preferred. Furthermore, low-substituted hydroxypropyl cellulose in accordance with the Japanese Pharmacopoeia is more preferable. Substituted hydroxypropyl cellulose can be produced by known methods, as well as commercially available products. You can use it. In the present invention, the particle form of low-substituted hydroxypropyl cellulose is not particularly limited. While not strictly necessary, a fine powder or fibrous form is more preferable, and a fibrous form is even more preferable.

[0045] In the present invention, low-substituted hydroxypropyl cellulose is 1 in proportion to the total mass of the composition. It is preferable to contain approximately 30% by mass, and more preferably 1-20% by mass. It is even more preferable to include 3 to 20% by mass.

[0046] The solid composition of the present invention is not particularly limited, but can be used, for example, in pharmaceuticals, quasi-drugs, or food products. Examples include pharmaceuticals and quasi-drugs.

[0047] The solid composition of the present invention is, in general, a dosage form specified in the General Rules for Formulations of the Japanese Pharmacopoeia. The formulation is not limited to tablets, but is preferably in the form of powders, granules, pills, or capsules. Tablets specified in the general rules of the Japanese Pharmacopoeia include orally disintegrating tablets, chewable tablets, and effervescent tablets. This includes dispersible tablets and dissolvable tablets, film-coated tablets, sugar-coated tablets, and laminated tablets. Tablets can be scored, marked, or engraved to improve identification. Furthermore, this formulation The tablets can be round, irregularly shaped, or mini-tablets.

[0048] The solid composition of the present invention contains, within a qualitative and quantitative range that does not impair the effects of the present invention, commonly used Other active ingredients, excipients, disintegrants, binders, fluidizers, lubricants, acidulants, sweeteners, flavor enhancers It contains cooling agents, colorants, foaming agents, surfactants, plasticizers, fragrances, coating agents, etc. It is possible.

[0049] Other active ingredients that can be incorporated into the solid composition of the present invention include, for example, antipyretic analgesics and antihistamines. Vitamins, cough suppressants, bronchodilators, expectorants, hypnotics and sedatives, vitamins, amino acids, anti-inflammatory drugs. Examples include symptomatic agents, gastric mucosal protective agents, herbal medicines, Kampo prescriptions, caffeine, etc., and groups consisting of these. It may contain one or more selected types.

[0050] Excipients that can be incorporated into the solid composition of the present invention include, for example, lactose, starches, and crystalline sugars. Examples include lullose, sucrose, sugar alcohols, calcium hydrogen phosphate, etc., as disintegrants. It is low-substituted hydroxypropylcellulose, sodium starch glycolate, cross Povidone, carmellose, carmellose sodium, carmellose calcium, alpha Examples include hydroxypropyl cellulose and hypromene. Examples include rose, gelatin, pregelatinized starch, polyvinylpyrrolidone, and pullulan. Examples of fluidizing agents include light anhydrous silicic acid and hydrated silicon dioxide, and as lubricants... It contains sucrose fatty acid ester, hydrogenated oil, stearic acid, magnesium stearate, stear Examples include calcium phosphate.

[0051] The tablets of the present invention can be manufactured by conventional methods for manufacturing tablets. In other words, this preparation is made by mixing the active pharmaceutical ingredient with the aforementioned additives using a suitable mixing machine such as a mixer. After mixing to produce a tablet mixture, the mixture is compressed directly into tablets, or granules are used. It can be manufactured by methods such as compression tableting. The method for manufacturing granules is dry granulation (S It can be manufactured by the lag method, roller compactor method, or wet granulation method, preferably This is a wet granulation method. Granulation equipment includes roller compactors, agitated granulation, and fluidized bed granulation. It can be manufactured by granulation, extrusion granulation, rolling granulation, spray granulation, etc. Tablet-grade mixed powder or For compressing the granular mixture into tablets, a single-shot tablet press, a rotary tablet press, or the like can be used. It is possible to be there. [Examples]

[0052] The present invention will be described in more detail below with reference to examples and comparative examples, but the present invention is not limited to these examples. This is not limited to examples, etc.

[0053] (Preparation of solid composition) (Examples 1-10, Comparative Examples 1-6) After weighing each raw material component according to the formulation shown in Table 1, they were mixed uniformly. The mixture was then mixed with an appropriate amount of water. The mixture of ethanol and other ingredients was added and kneaded in a mortar, granulated, and then thoroughly dried. After that, the entire amount The material was passed through a sieve (mesh size 710 μm) to obtain granules, which were then compressed into tablets.

[0054] [Table 1]

[0055] Stability test (change in content) Regarding the obtained tablets, samples were taken at the start of the test and after being stored for 1 day under 65°C conditions. The content of thiamine nitrate, riboflavin, pyridoxine hydrochloride, and cyanocobalamin was measured. Then, the survival rate was calculated. The results are shown in Table 2.

[0056] [Table 2]

[0057] As shown in Table 2, the product does not contain taurine and is low-substituted hydroxypropylcellulose. Comparative Example 1 contains only [specific ingredient], while Comparative Examples 2-5 contain no taurine and are comparable in their vitamin B group formulations. The remaining percentage was 90% or less in all cases. On the other hand, in Example 1, which contained only taurine, Compared to Comparative Examples 1-3, it was found that the retention rate of B vitamins was dramatically improved. Ta. Example 2 also contains both taurine and low-substituted hydroxypropyl cellulose. In Example 8, the retention rate of all B vitamins was 90% or higher, and the retention rate is expected to improve further. This became clear. In Comparative Example 6, which contained calcium ascorbate, the residual rate of cyanocobalamin was 80% or less. The result was as follows: Implementation using a mixture of taurine and low-substituted hydroxypropyl cellulose. In Examples 9 and 10, the residual rate of cyanocobalamin was over 90%, dramatically reducing cyanocobalamin levels. It became clear that the survival rate of the substance improved. [Industrial applicability]

[0058] According to the present invention, in a solid composition containing vitamins and taurine, storage stability is improved. This can provide an excellent solid composition.

Claims

1. (A) Vitamin B1, vitamin B2, vitamin B6, and ascorbic acid or the same (B) contains at least one selected from salt, vitamin B12, and (C) taurine. A solid composition characterized by [something].

2. Furthermore, the solid according to claim 1, which further contains (D) low-substituted hydroxypropyl cellulose composition.

3. (A) The solid composition according to claim 1 or 2, wherein the vitamin B1 is thiamine or a salt thereof. thing.

4. (A) The solid according to claim 1 or 2, wherein the vitamin B2 is riboflavin or a salt thereof. composition.

5. (A) The solid composition according to claim 1 or 2, wherein the vitamin B6 is pyridoxine or a salt thereof. A finished product.

6. (B) The vitamin B12 is cyanocobalamin or mecobalamin, claim 1 or 2 The solid composition described above.

7. (C) The claim 1 or 2, wherein the taurine is synthetic taurine or taurine derived from marine products. A solid composition.

8. (C) Taurine is 30 to 90% by mass of the total mass of the composition as described in claim 1 or 2. A solid composition.

9. The solid composition according to claim 1 or 2, which is a tablet, granule, powder, or capsule.

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