Oral components

Abstract

The present invention provides an oral composition that can effectively suppress the bitter taste after use, even when pyridoxine or a salt thereof is used. [Solution] An oral composition comprising (A) component: pyridoxine or a salt thereof, and (B) component: inorganic powder, wherein the content of component (A) is 0.01% to 3% by mass, and the content of component (B) is 0.01% or more and less than 15% by mass.

Description

Technical Field

[0001] The present invention relates to an oral composition.

Background Art

[0002] Conventionally, from the viewpoint of imparting effects such as a periodontal disease preventive effect, more specifically, a short-chain fatty acid reduction effect, a glycation reaction inhibitory effect, a metabolism promotion effect, and an anti-inflammatory effect, a mode of blending pyridoxine (vitamin B6) or a salt thereof in an oral composition has been known.

[0003] Specifically, for example, in Patent Document 1 below, an aspect of containing tocopherol nicotinate and / or tocopherol acetate together with pyridoxine or a salt thereof in an oral composition for the purpose of stably containing pyridoxine or a salt thereof is described.

Prior Art Documents

Patent Documents

[0004]

Patent Document 1

Summary of the Invention

Problems to be Solved by the Invention

[0005] If pyridoxine or a salt thereof is blended as a component of an oral composition, favorable properties such as astringency in the oral mucosa can be imparted. However, depending on the blending amount of pyridoxine or a salt thereof, the favorable desired flavor due to components such as flavors and sweeteners that can be contained in the oral composition may be lost, and an unpleasant bitter taste may be felt after use.

[0006] Therefore, an object of the present invention is to provide an oral composition capable of effectively suppressing the bitter taste after use.

Means for Solving the Problems

[0007] The inventors diligently conducted research to suppress the bitter taste sensation after use of an oral composition containing a predetermined amount of pyridoxine or its salt. They discovered that the above problem could be solved by incorporating a predetermined amount of inorganic powder, and thus completed the present invention. In other words, the present invention provides the following [1] to [9]. [1] (A) Components: Pyridoxine or a salt thereof, (B) Components: Contains inorganic powder, (A) The content of component is 0.01% by mass to 3% by mass, (B) An oral composition having a content of component 0.01% by mass or more and less than 15% by mass. [2] The oral composition according to [1], wherein component (B) is one or more selected from the group consisting of thickening anhydrous silicic acid, abrasive anhydrous silicic acid, heavy calcium carbonate, anhydrous calcium hydrogen phosphate, titanium dioxide, aluminum oxide, and zinc oxide. [3] (C) component: The oral composition according to [1] or [2], further comprising one or more selected from the group consisting of polyethylene glycol and propylene glycol. [4] The oral composition according to [3], wherein the content of component (C) is 0.05% to 10% by mass. [5] (D) Components: Oral composition according to any one of [1] to [4], further comprising one or more selected from the group consisting of sodium saccharin, sucralose, xylitol, erythritol, maltitol, acesulfame potassium, trehalose, and mannitol. [6] The oral composition according to [5], wherein the content of component (D) is 0.01% to 10% by mass. [7] (E) component: The oral composition according to any one of [1] to [6], further comprising one or more selected from the group consisting of tocopherol acetate and tocopherol nicotinate. [8] The oral composition according to [7], wherein the content of component (E) is 0.03% to 2% by mass. [9] An oral composition according to any one of [1] to [8], wherein the ratio of the content of component (A) to the content of component (B) ((A) / (B)) is 0.0003 to 20. [Effects of the Invention]

[0008] According to the present invention, in an oral composition containing a predetermined amount of pyridoxine, the bitterness after use caused by the inclusion of pyridoxine or a salt thereof can be effectively suppressed. [Modes for carrying out the invention]

[0009] The oral composition of the present invention will be described in detail below. The oral composition of the present invention comprises (A) component: pyridoxine or a salt thereof, and (B) component: inorganic powder, wherein the content of component (A) is 0.01% to 3% by mass, and the content of component (B) is 0.01% or more and less than 15% by mass.

[0010] First, we will describe components (A) and (B) included in the oral composition of this embodiment, as well as components (C), (D), and (E) that may be included in the oral composition of this embodiment, and any other optional components that may be included.

[0011] [(A) Ingredients: Pyridoxine or its salt] (A) Pyridoxine or its salt, which is component (A), is a component that can impart a periodontal disease prevention effect. According to the oral composition of this embodiment, pyridoxine or its salt is a component that can also impart an astringent sensation, particularly on the oral mucosa, when used.

[0012] In this embodiment, the pyridoxine salt is not particularly limited as long as it is a pharmaceutically acceptable salt that exhibits the effects described above. Examples of pyridoxine salts include pyridoxine hydrochloride, pyridoxine sulfate, pyridoxine nitrate, pyridoxine hydrobromide, and pyridoxine phosphate. Among the pyridoxine salts, pyridoxine hydrochloride is preferred.

[0013] Here, pyridoxine hydrochloride (pyridoxine hydrochloride) is a salt of pyridoxine and is a type of vitamin B6. (A) The component may be pyridoxine or a salt thereof, either alone or in combination of two or more.

[0014] In the oral composition of this embodiment, the content of component (A) is 0.01% by mass or more, preferably 0.015% by mass or more, and more preferably 0.02% by mass or more, when the total amount of the oral composition is 100% by mass, from the viewpoint of providing a good periodontal disease prevention effect and astringent sensation. Furthermore, the content of component (A) is 3% by mass or less, preferably 2% by mass or less, or 1% by mass or less, and more preferably 0.5% by mass or less. Therefore, the content of component (A) is 0.01% by mass to 3% by mass, preferably 0.01% by mass to 2% by mass, or 0.01% by mass to 1% by mass, more preferably 0.02% by mass to 1% by mass, or 0.02% by mass to 0.5% by mass.

[0015] [(B) Component: Inorganic powder] The inorganic powder component (B) is an ingredient that can effectively suppress the bitterness that may occur, especially after brushing your teeth, when combined with the previously described component (A).

[0016] (B) component includes, for example, inorganic calcium salts (e.g., dicalcium phosphate dihydrate or anhydrate, monocalcium phosphate, calcium pyrophosphate, insoluble calcium metaphosphate, tricalcium phosphate, tetracalcium phosphate, octacalcium phosphate, etc.), calcium carbonate (light, heavy), calcium hydroxide, calcium sulfate, calcium oxide); silica-based powders (anhydrous silicic acid (e.g., thickening anhydrous silicic acid (thickening silica), abrasive anhydrous silicic acid (abrasive silica)), zeolite, etc.); inorganic aluminum salts such as aluminum hydroxide, alumina; inorganic magnesium salts such as magnesium carbonate, magnesium phosphate tribasic; apatite-based powders such as hydroxyapatite, fluorapatite, calcium-deficient apatite; bentonite; titanium dioxide (titanium oxide); aluminum oxide; zinc oxide; and sodium hydrogen phosphate. (B) component may be used alone as one of the above inorganic powders, or may be used in combination of two or more, and commercially available products can also be used.

[0017] In this embodiment, as (B) component, silica-based powders and inorganic metal salts are preferred, and it is more preferred to use one or more selected from the group consisting of thickening anhydrous silicic acid (thickening silica), abrasive anhydrous silicic acid (abrasive silica), heavy calcium carbonate, anhydrous calcium hydrogen phosphate, titanium dioxide, aluminum oxide, and zinc oxide, and it is even more preferred to use one or more selected from the group consisting of thickening anhydrous silicic acid, abrasive anhydrous silicic acid, titanium dioxide, and aluminum oxide.

[0018] Examples of abrasive anhydrous silicic acid include precipitated silica, crystalline silica, pyrogenic silica, amorphous silica, silica gel, aluminosilicate, zirconosilicate, and titanium-bonded silica. Among these, compounds mainly composed of silicates such as precipitated silica, aluminosilicate, zirconosilicate, and titanium-bonded silica, and calcium carbonate are particularly preferred. Precipitated silica includes, for example, those having a particle size of 1 μm to 40 μm and a BET specific surface area of 10 to 250 square meters per gram. Here, the average particle size is the volume-based median diameter (D50) measured by the laser diffraction / scattering method. As the abrasive anhydrous silicic acid, these abrasive anhydrous silicic acids may be used alone or in combination of two or more, and commercial products may also be used.

[0019] Examples of thickening anhydrous silicic acid include silica obtained by known production methods such as precipitated silica and pyrogenic silica having a liquid absorption of 2 mL / g to 5 mL / g. The thickening anhydrous silicic acid is preferably thickening silica having a specific surface area of 170 m 2 / g to 230 m 2 / g, and / or thickening silica having a bulk density of 130 g / L to 160 g / L. As the thickening anhydrous silicic acid, these thickening anhydrous silicic acids may be used alone or in combination of two or more, and commercial products may also be used.

[0020] In the oral composition of the present embodiment, the content of component (B) is 0.01% by mass or more, preferably 0.1% by mass or more, more preferably 1% by mass or more from the viewpoint of ensuring astringency during toothbrushing and effectively suppressing bitterness that may be caused by the formulation of component (A) and the taste of component (B) itself when the total amount of the oral composition is 100% by mass. Also, the content of component (B) is less than 15% by mass. Therefore, the content of component (B) is 0.01% by mass or more and less than 15%, preferably 0.1% by mass or more and less than 15% by mass, more preferably 1% by mass or more and less than 15% by mass.

[0021] [Component (C): polyethylene glycol and propylene glycol] Component (C) is one or more selected from the group consisting of polyethylene glycol and propylene glycol. Component (C) is a component that can effectively suppress the decrease in the stability of pyridoxine hydrochloride during low-temperature (-5°C) storage that may occur as a result of the formulation of components (A) and (B) as described above.

[0022] In this embodiment, the polyethylene glycol may have an average molecular weight of 150 to 6000. The polyethylene glycol that can be used as component (C) is preferably polyethylene glycol with an average molecular weight of 190 to 4000. Here, the average molecular weight is the average molecular weight as defined in the Japanese Standards for Ingredients of Quasi-Drugs 2021.

[0023] Examples of polyethylene glycol as component (C) include PEG200, PEG300, PEG400, PEG600, and PEG4000. Among these, polyethylene glycol 4000 (PEG4000), which has an average molecular weight of 2600 to 3800, is preferred.

[0024] Therefore, as component (C), one or more selected from the polyethylene glycol and / or propylene glycol exemplified above can be used, and polyethylene glycol 4000 and / or propylene glycol is preferred. As component (C), polyethylene glycol and propylene glycol exemplified above may be used individually or in combination of two or more, and commercially available products may be used.

[0025] The content of component (C) is not particularly limited. From the viewpoint of improving the stability of pyridoxine hydrochloride during low-temperature storage and effectively exerting the suppression of unpleasant taste by components (D) and (E) described later, the content of component (C) is preferably 0.05% by mass or more, more preferably 0.1% by mass or more, or 0.2% by mass or more, and even more preferably 1% by mass or more, when the total amount of the oral composition is 100% by mass. Furthermore, the content of component (C) is preferably 10% by mass or less, more preferably 8% by mass or less, and even more preferably 6% by mass or less. Therefore, the content of component (C) is preferably 0.05% by mass to 10% by mass, or 0.05% by mass to 8% by mass, more preferably 0.1% by mass to 8% by mass, or 0.2% by mass to 8% by mass, and even more preferably 0.2% by mass to 6% by mass, or 1% by mass to 6% by mass.

[0026] [(D) Ingredients: Sodium saccharin, sucralose, xylitol, erythritol, maltitol, acesulfame potassium, trehalose, and mannitol] Component (D) is an ingredient that can effectively suppress the unpleasantness that may arise from the combined use of components (A) and (B) as described above, as well as from the combined use of components (A), (B), and (C).

[0027] In this embodiment, from the viewpoint of effectively suppressing the unpleasant taste that may arise from the combination of components (A) and (B) already described, the combination of components (A), (B), and (C), and even from the taste of component (D) itself, component (D) is preferably one or more selected from the group consisting of sodium saccharin, sucralose, xylitol, erythritol, maltitol, acesulfame potassium, trehalose, and mannitol, and it is more preferable to use sodium saccharin and / or xylitol. Component (D) may be one of the examples above used alone, or two or more may be used in combination, and commercially available products may also be used.

[0028] In the oral composition of this embodiment, the content of component (D) is not particularly limited. From the viewpoint of effectively suppressing the unpleasant taste that may arise from the combined use of components (A) and (B), and from the taste of component (D) described later, the content of component (D) is preferably 0.005% by mass or more, more preferably 0.015% by mass or more, more preferably 0.02% by mass or more, and even more preferably 0.05% by mass or more, when the total amount of the oral composition is 100% by mass. Furthermore, the content of component (D) is preferably 13% by mass or less, or 10% by mass or less, more preferably 7% by mass or less, 5% by mass or less, even more preferably 2% by mass or less, or 1% by mass or less, or 0.5% by mass or less. Therefore, the content of component (D) is preferably 0.005% to 13% by mass, or 0.01% to 10% by mass, and more preferably 0.015% to 7% by mass, 0.02% to 5% by mass, 0.02% to 2% by mass, 0.05% to 1% by mass, or 0.05% to 0.5% by mass.

[0029] [(E) Components: Tocopherol acetate and tocopherol nicotinate] (E) Component is one or more selected from the group consisting of tocopherol acetate and tocopherol nicotinate. Component (E) is an ingredient that exerts a periodontal disease prevention effect in oral compositions and can effectively suppress the unpleasant taste that may arise from the combined use of components (A) and (B) as described above, as well as from the combined use of components (A), (B), and (C).

[0030] In this embodiment, examples of tocopherol acetate and tocopherol nicotinate esters as component (E) include d-α-tocopherol acetate, dl-α-tocopherol acetate, d-α-tocopherol nicotinate, and dl-α-tocopherol nicotinate. Component (E) may be used alone, in combination of two or more, or a commercially available product may be used.

[0031] In this embodiment, component (E) is preferably one or more of d-α-tocopherol acetate, dl-α-tocopherol acetate, d-α-tocopherol nicotinate, or dl-α-tocopherol nicotinate, used alone or in combination of two or more, from the viewpoint of effectively suppressing the unpleasant taste that may arise from the combination of components (A) and (B) already described, or the combination of components (A), (B), and (C), and exhibiting a periodontal disease preventive effect, and more preferably dl-α-tocopherol acetate, dl-α-tocopherol acetate, dl-α-tocopherol nicotinate, and more preferably dl-α-tocopherol acetate, dl-α-tocopherol nicotinate, and even more preferably dl-α-tocopherol acetate.

[0032] In the oral composition of this embodiment, the content of component (E) is not particularly limited. From the viewpoint of effectively suppressing unpleasant taste, the content of component (E) is preferably 0.01% by mass or more, 0.02% by mass or more, or 0.03% by mass or more, more preferably 0.04% by mass or more, or 0.05% by mass or more, when the total amount of the oral composition is 100% by mass. Furthermore, the content of component (E) is preferably 4% by mass or less, 3% by mass or less, or 2% by mass or less, more preferably 1.5% by mass or less, or 1% by mass or less. Therefore, the content of component (E) is preferably 0.01% by mass to 4% by mass, 0.02% by mass to 3% by mass, or 0.03% by mass to 2% by mass, more preferably 0.03% by mass to 1.5% by mass, 0.04% by mass to 1.5% by mass, or 0.05% by mass to 1% by mass.

[0033] In the oral composition of this embodiment, component (E) is more preferably used in combination with component (D) from the viewpoint of more effectively suppressing the unpleasant taste that may arise from the above-mentioned combination of components (A), (B), and (C).

[0034] [Content ratio] -(A) / (B)(mass ratio)- The ratio of the content of component (A) to the content of component (B) ((A) / (B)) is preferably 0.0003 or more, more preferably 0.0007 or more, and even more preferably 0.001 or more. The ratio ((A) / (B)) is also preferably 20 or less, more preferably 10 or less, even more preferably 5 or less, or 1 or less, even more preferably 0.8 or less, or 0.3 or less. Therefore, the ratio ((A) / (B)) is preferably 0.0003 to 20, 0.0007 to 20, or 0.0007 to 10, more preferably 0.0007 to 5, or 0.007 to 1, and even more preferably 0.001 to 0.8, or 0.001 to 0.3. By setting the ratio ((A) / (B)) in this way, it is possible to ensure an astringent sensation in the oral mucosa during use and effectively suppress bitterness after use.

[0035] -((A)+(B)) / (C)(mass ratio)- The ratio ((A)+(B)) / (C) of the sum of the content of component (A) and the content of component (B) to the content of component (C) is preferably 0.002 or more, or 0.02 or more, more preferably 0.05 or more, or 0.1 or more, and even more preferably 0.3 or more. Also, the ratio ((A)+(B)) / (C) is preferably 360 or less, or 300 or less, more preferably 200 or less, or 80 or less, and even more preferably 40 or less, 10 or less, or 6 or less. Therefore, the ratio ((A)+(B)) / (C) is preferably 0.002 to 360, or 0.02 to 300, more preferably 0.05 to 200, or 0.1 to 80, and even more preferably 0.3 to 40, 0.3 to 10, or 0.3 to 6. By setting the ratio ((A)+(B)) / (C) in this way, it is possible to ensure an astringent sensation in the oral mucosa during use, further improve the stability of pyridoxine hydrochloride during low-temperature storage, and effectively suppress bitterness after use.

[0036] -((A)+(B)+(C)) / (D)(mass ratio)- The ratio ((A)+(B)+(C)) / (D) to the content of component (D), which is the sum of the content of component (A), component (B), and component (C), is preferably 0.007 or more, more preferably 1 or more, even more preferably 10 or more, and even more preferably 30 or more. Also, the ratio ((A)+(B)+(C)) / (D) is preferably 2800 or less, more preferably 2000 or less, even more preferably 1200 or less, and even more preferably 500 or less. Therefore, the ratio ((A)+(B)+(C)) / (D) is preferably 0.007 to 2800, more preferably 1 to 2000, even more preferably 10 to 1200, and even more preferably 30 to 500. By calculating ((A)+(B)+(C)) / (D) in this way, it is possible to ensure an astringent sensation in the oral mucosa during use, further improve the stability of pyridoxine hydrochloride during low-temperature storage, more effectively suppress unpleasant tastes during use, and effectively suppress bitterness after use.

[0037] -((A)+(B)+(C)) / (E)(mass ratio)- The ratio ((A)+(B)+(C)) / (E) to the content of component (E), which is the sum of the content of component (A), component (B), and component (C), is preferably 0.03 or more, more preferably 0.3 or more, even more preferably 1 or more, and even more preferably 6 or more. Also, the ratio ((A)+(B)+(C)) / (E) is preferably 1000 or less, more preferably 700 or less, even more preferably 500 or less, and even more preferably 250 or less. Therefore, the ratio ((A)+(B)+(C)) / (E) is preferably 0.03 to 1000, more preferably 0.3 to 700, even more preferably 1 to 500, and even more preferably 6 to 250. By setting the ratio ((A)+(B)+(C)) / (E) in this way, it is possible to ensure an astringent sensation in the oral mucosa during use, further improve the stability of pyridoxine hydrochloride during low-temperature storage, more effectively suppress unpleasant tastes during use, and effectively suppress bitterness after use.

[0038] [Optional ingredients] The oral composition of this embodiment may contain optional components other than those already described, provided that the effects and benefits of the present invention are not impaired. These will be described in detail below.

[0039] Optional components in this embodiment include, for example, solvents, surfactants, sweeteners, fragrances, medicinal ingredients, oily components, preservatives, wetting agents, abrasives, binders, pH adjusters, and colorants (pigments). These can be formulated individually or in appropriate combinations of two or more. A detailed explanation follows below.

[0040] In this specification, the content of each component is based on the amount of each component used when manufacturing the oral composition.

[0041] -solvent- The oral composition of this embodiment may further contain a solvent. Preferably, water (purified water) or ethanol can be used as the solvent. The solvent may be one of the above solvents alone, two or more solvents in combination, or a commercially available product may be used.

[0042] - Surfactants - The oral composition of this embodiment may further contain a surfactant. Examples of surfactants include anionic surfactants, nonionic surfactants, cationic surfactants, and amphoteric surfactants.

[0043] Examples of anionic surfactants include alkyl sulfates, acyl amino acid salts, acyl taurine salts, α-olefin sulfonates, hydrogenated coconut fatty acid monoglyceride monosulfates, lauryl sulfoacetate, and polyoxyethylene alkyl sulfosuccinate. The alkyl and acyl groups may be linear or branched, saturated or unsaturated, and the number of carbon atoms is preferably 10 to 20, more preferably 12 to 18, and even more preferably 12 to 14. The average number of ethylene oxide added to the polyoxyethylene alkyl sulfosuccinate is preferably 1 to 9. The salt can be selected from pharmacologically acceptable salts. Examples of pharmacologically acceptable salts include base addition salts and amino acid salts. Specific examples include inorganic base salts such as sodium salt, potassium salt, calcium salt, magnesium salt, and ammonium salt; organic base salts such as triethylammonium salt, triethanolammonium salt, pyridinium salt, and diisopropylammonium salt; and basic amino acid salts such as arginine salt. In particular, inorganic base salts are preferred, alkali metal salts (e.g., sodium salts, potassium salts) or ammonium salts are more preferred, and sodium salts are even more preferred.

[0044] Examples of alkyl sulfates include lauryl sulfate (sodium lauryl sulfate) and myristoyl sulfate. Examples of acyl amino acid salts include acyl sarcosine salts such as lauroyl sarcosine salt and myristoyl sarcosine salt; acyl glutamates such as lauroyl glutamate, myristoyl glutamate, and palmitoyl glutamate; acyl glycine salts such as N-lauroyl-N-methylglycine salt and cocoyl glycine salt; acyl alanine salts such as N-lauroyl-β-alanine salt, N-myristyl-β-alanine salt, N-cocoyl-β-alanine salt, N-lauroyl-N-methyl-β-alanine salt, N-myristoyl-N-methyl-β-alanine salt, and N-methyl-N-acyl alanine salt; and acyl aspartates such as lauroyl aspartate salt. Examples of acyl taurine salts include lauroyl methyl taurine salt, N-methyl-N-acyl taurine salt, and N-cocoyl methyl taurine salt. Examples of α-olefin sulfonates include α-olefin sulfonates with 12 to 18 carbon atoms, such as tetradecene sulfonate. Other examples of anionic surfactants include hydrogenated coconut fatty acid monoglyceride monosulfate sodium and lauryl sulfoacetate sodium.

[0045] Examples of nonionic surfactants include polyoxyethylene hydrogenated castor oil, polyoxyethylene alkyl ethers, polyoxyethylene-polyoxypropylene alkyl ethers, glycerin fatty acid esters, polyglycerin fatty acid esters, alkyl glycosides, sorbitan fatty acid esters, polyoxyethylene sorbitan fatty acid esters (e.g., polyoxyethylene sorbitan monostearate, polyoxyethylene sorbitan monooleate), alkylolamides, polyoxyethylene fatty acid esters, polyoxyethylene alkenyl ethers, sucrose fatty acid esters (e.g., sucrose stearate, sucrose palmitate), sugar alcohol fatty acid esters (e.g., maltitol fatty acid ester, lactitol fatty acid ester), fatty acid ethanolamides (e.g., lauric acid mono or diethanolamide), polyoxyethylene polyoxypropylene block copolymers, and polyoxyethylene polyoxypropylene fatty acid esters. The average number of moles of ethylene oxide added to polyoxyethylene hydrogenated castor oil is preferably 5 to 100 moles, more preferably 5 to 60 moles. The number of carbon atoms in the alkyl chain of polyoxyethylene alkyl ether is preferably 10 to 26, and the average number of moles of ethylene oxide added is preferably 2 to 50 moles. The number of carbon atoms in the fatty acid of polyglycerin fatty acid ester is preferably 10 to 20, and the average degree of polymerization of glycerin is preferably 1 to 20. The average number of moles of ethylene oxide added to polyoxyethylene-polyoxypropylene alkyl ether is preferably 10 to 300 moles, the average number of moles of propylene oxide added is preferably 5 to 70 moles, and the number of carbon atoms in the alkyl group is preferably 10 to 20. The number of carbon atoms in the alkyl group of alkyl glycoside is preferably 8 to 20. The number of carbon atoms in the fatty acid of sucrose fatty acid ester is preferably 8 to 20. The number of carbon atoms in the fatty acid of sorbitan fatty acid ester is preferably 10 to 18. The number of carbon atoms in the fatty acid of the polyoxyethylene sorbitan fatty acid ester is preferably 12 to 18, and the average number of moles of ethylene oxide added is preferably 20 to 80 moles. The number of carbon atoms in the alkyl chain of the alkylolamide is usually 12 to 14.

[0046] Examples of cationic surfactants include quaternary ammonium salt type cationic surfactants and amino acid-based cationic surfactants. Examples of quaternary ammonium salts include alkylpyridinium salts, benzethonium salts, benzalkonium salts, monoalkyltrimethylammonium salts, and dialkyldimethylammonium salts. Examples of salts include chloride salts and bromide salts. Examples of alkyl groups in alkylpyridinium salts, monoalkyltrimethylammonium salts, or dialkyldimethylammonium salts include alkyl groups having 8 to 22 carbon atoms. The upper or lower limit of the number of carbon atoms may be, for example, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, or 21. More specifically, it may be, for example, 9 to 21. Examples of quaternary ammonium salt type cationic surfactants include cetylpyridinium chloride, benzalkonium chloride, benzethonium chloride, stearyltrimethylammonium chloride, cetyltrimethylammonium chloride, stearyltrimethylammonium chloride, behenyltrimethylammonium chloride, distearyldimethylammonium chloride, laurylbenzyldimethylammonium chloride, hexadecyltrimethylammonium bromide, and stearyltrimethylammonium bromide. Examples of amino acid-based cationic surfactants include mono-N-long-chain acyl basic amino acid lower alkyl ester salts. Examples of basic amino acids constituting amino acid-based cationic surfactants include natural amino acids such as ornithine, lysine, and arginine. Synthetic amino acids such as α,γ-diaminobutyric acid can also be used. These may be optically active or racemic. The acyl group of the mono-N-long-chain acyl basic amino acid lower alkyl ester salt is preferably a saturated or unsaturated higher fatty acid residue with 8 to 22 carbon atoms. The upper or lower limit of the number of carbon atoms may be, for example, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, or 21. More specifically, it may be 9 to 21. Examples include single higher fatty acid residues such as lauroyl group, myristoyl group, palmitoyl group, and stearoyl group; and natural mixed higher fatty acid residues such as coconut oil fatty acid residues and beef tallow higher fatty acid residues. Examples of lower alkyl esters include alkyl esters having 1 to 8 carbon atoms. Specifically, these include methyl esters, ethyl esters, propyl esters, butyl esters, pentyl esters, hexyl esters, heptyl esters, and octyl esters. Lower alkyl esters are preferably in salt form, and examples include inorganic salts such as hydrochloride, bromate, sulfate, and phosphate; and organic salts such as glycolate, acetate, lactate, succinate, tartrate, citrate, acidic amino acid salts, higher fatty acid salts, L- or DL-pyrrolidone carboxylate salts, pyroglutamate, and p-toluenesulfonate. Examples of amino acid-based cationic surfactants include N-coconut oil fatty acid acyl-L-arginine ethyl DL-pyrrolidone carboxylate.

[0047] Examples of amphoteric surfactants include betaine-type amphoteric surfactants such as alkyldimethylaminoacetic acid betaine (e.g., lauryldimethylaminoacetic acid betaine), fatty acid amidopropyl betaine (e.g., coconut oil fatty acid amidopropyl betaine, cocamidopropyl betaine), and alkyl betaine (e.g., lauryl betaine, stearyl betaine); and imidazoline-type amphoteric surfactants such as N-fatty acid acyl-N-carboxymethyl-N-hydroxyethylethylenediamine salts (e.g., N-coconut oil fatty acid acyl-N-carboxymethyl-N-hydroxyethylimidazolinium betaine), coconut oil fatty acid imidazolinium betaine, and 2-alkyl-N-carboxymethyl-N-hydroxyethylimidazolinium betaine. The surfactants may be used individually, in combination of two or more, or commercially available products may be used.

[0048] In this embodiment, the content of the optional surfactant is preferably 0.001% by mass or more, more preferably 0.01% by mass or more, and even more preferably 0.1% by mass or more, when the total amount of the oral composition is considered as 100% by mass. Furthermore, the surfactant content is preferably 15% by mass or less, more preferably 10% by mass or less, and even more preferably 5.5% by mass or less. Therefore, the surfactant content is preferably 0.001% by mass to 15% by mass, preferably 0.01% by mass to 10% by mass, and even more preferably 0.1% by mass to 5.5% by mass.

[0049] -Sweetener- The oral composition of this embodiment may contain sweeteners other than component (D) in any suitable amount, as long as it does not impair the effects of the present invention.

[0050] Examples of sweeteners include aspartame, stevioside, stevia extract, paramethoxycinnamic aldehyde, neohesperidin dihydrochalcone, perillartin, thaumatin, and aspartylphenylalanine methyl ester. The sweeteners listed above may be used individually, in combination of two or more, or commercially available products may be used.

[0051] -Fragrance (fragrance composition)- The oral composition of this embodiment may contain a conventionally known, optionally suitable fragrance (fragrance composition) in an optionally suitable amount. Including a fragrance in the oral composition can further improve the user experience.

[0052] As fragrances, for example, natural essential oils such as peppermint oil, spearmint oil, Japanese mint oil, anise oil, cassia oil, eucalyptus oil, wintergreen oil, mastic oil, neroli oil (orange blossom oil), lemongrass oil, jasmine oil, rose oil, iris oil, thyme oil, sage oil, cardamom oil, coriander oil, rosemary oil, laurel oil, chamomile oil, caraway oil, basil oil, marjoram oil, lemon oil, orange oil, lime oil, grapefruit oil, mandarin oil, yuzu oil, nutmeg oil, lavender oil, paraclete oil, vanilla oil, cinnamon oil, pimento oil, cinnamon leaf oil, and perilla oil; menthol, carvone, cinnamic aldehyde, anethole, 1,8-cineole, methyl salicylate, eugenol, thymol, linalool, limonene, menthone, menthyl acetate, citral, decanal, Fragrance components contained in the above natural essential oils, such as camphor, borneol, pinene, spiranthol, menthyl succinate, n-decyl alcohol, citronellol, α-terpineol, menthofran, linalool oxide, vanillyl butyl ether, linalyl acetate, phenylethyl glycidate, phenylethyl alcohol, allyl hexanoate, octanol (3-octanol), octanal (3-octanal), octyl acetate (3-octyl acetate), caryophyllene (caryophyllene-BE), germacrene (germacrene D), viridiflorol, methyl cinnamate, methylheptin carbonate, ionone, ethyl-β-methylthiopropionate, cis-6-nonenol, carone, methyl jasmonate, citronellyl acetate, and ethyl linalool;Ethyl acetate, ethyl butyrate, ethyl-2-methyl butyrate, isoamyl acetate, hexanal, hexenal (trans-2-hexenal), hexyl acetate, methyl anthranilate, ethylmethylphenyl glycidate, benzyl alcohol, benzaldehyde, maltol, ethyl maltol, vanillin, ethyl vanillin, furaneol, ethylcyclopentenone, 3-hydroxy-4,5-dimethylfuran-2-one, cyclotene, 2-methylbutyric acid, acetate acid, propionic acid, p-methoxycinnamic aldehyde, cis-3-hexenol, undecalactone, decalactone, N-ethyl-p-menthane-3-carboxamide, N-ethyl-2-isopropyl-5-methylcyclohexanecarboxamide, Fragrance components such as N-[(ethoxycarbonyl)methyl]-p-menthane-3-carboxamide, Np-benzeneasotonitrile menthanecarboxamide, N-(2-(pyridine-2-yl)ethyl)-3-p-menthanecarboxamide, N-(2-hydroxy-2-phenylethyl)-2-isopropyl-5,5-dimethylcyclohexane-1-carboxamide, 2-(4-methylphenoxy)-N-(1H-pyrazole-yl)-N-(thiophen-2-ylmethyl)acetamide, N-(4-methoxyphenyl)-p-menthanecarboxamide, menthyl glyceryl ether, menthyl lactate, ethylene glycol-l-menthyl carbonate, etc.; plant extracts such as vanilla extract, chili pepper extract, ginger extract, pepper extract, Japanese pepper extract, cardamom extract, etc.In addition, various blended flavors such as mint, fruit, and herb, which are made by combining several fragrance components and natural essential oils, can be mentioned. Furthermore, fragrances that can also function as cooling agents include, for example, N-ethyl-p-menthane-3-carboxamide, menthyl lactate, menthyl monosuccinate, isopulegol, menthol glycoside ketal, N-(4-cyanomethylphenyl)-p-menthanecarboxamide, 3-l-mentoxypropane-1,2-diol, 5-methyl-2-propane-2-yl-N-(2-pyridine-2-ylethyl)cyclohexane-1-carboxamide, 3-(p-menthane-3-carboxamide Other examples include ethyl acetate (Samide), 2-isopropyl-N,2,3-trimethylbutylamide, N-ethyl-2,2-diisopropylbutanamide, N-(1,1-dimethyl-2-hydroxyethyl)-2,2-diethylbutanamide, N-(2-hydroxyethyl)-2,3-dimethyl-2-isopropylbutanamide, menthyl glutarate, 2-(4-methylphenoxy)-N-(1H-pyrazole-yl)-N-(thiophen-2-ylmethyl)acetamide, and isopuregol. As for the fragrance, one of the above example fragrances may be used alone, two or more may be used in combination (as a fragrance composition), and commercially available products may also be used. If the oral composition contains a fragrance (fragrance composition), its content is preferably 0.0000001% to 5% by mass, more preferably 0.00001% to 3% by mass, and even more preferably 0.01% to 2% by mass, based on 100% by mass of the total amount of the oral composition. If the oral composition contains a fragrance that can also function as a cooling agent, its content is preferably 0.00001% to 0.01% by mass, based on 100% by mass of the total amount of the oral composition. Furthermore, when these fragrances are combined to form a fragrance composition, a solvent may be used. Examples of such solvents include ethanol, propylene glycol, glycerin fatty acid esters, and triacetin.

[0053] -Medicinal ingredients- Medicinal ingredients include, for example, enzymes such as dextranase, amylase, protease, and mutanase; anti-inflammatory agents such as tranexamic acid, allantoin, allantoin chlorohydroxyaluminum, ε-aminocaproic acid, azulene, sodium azulene sulfonate, glycyrrhizic acid or its salts (e.g., dipotassium glycyrrhizate), glycyrrhetinic acid or its salts (e.g., stearyl glycyrrhetinate), Phellodendron amurense, and Phellodendron amurense extract; cell activators such as sodium chloride and vitamins; and bactericidal or antibacterial agents such as isopropylmethylphenol, cetylpyridinium chloride, benzalkonium chloride, benzethonium chloride, hinokitiol, thymol, lysozyme chloride, chlorhexidine, triclosan, zinc gluconate, and zinc citrate. Examples of oral compositions include water-soluble copper compounds such as copper chlorophyll and copper gluconate; tartar preventatives such as zeolites, ethane hydroxydiphosphonates, and polyphosphates (e.g., sodium polyphosphate); vitamins such as vitamin C (e.g., ascorbic acid) and vitamin E (e.g., vitamin E other than component (E), such as tocopherol); astringents such as sodium chloride, alum, and lysozyme chloride; hypersensitivity inhibitors such as potassium nitrate, aluminum lactate, and strontium chloride; amino acids such as alanine, glycine, proline, arginine, lysine, glutamine, and cysteine; peptides such as caropeptides; fluoride compounds such as sodium fluoride, sodium monofluorophosphate, and stannous fluoride; and plant extracts such as thyme, scutellaria baicalensis, clove, and witch hazel. When an oral composition contains medicinal ingredients, the amount can be an effective amount within a range that does not hinder the effects of the present invention (a range that is pharmacologically acceptable). The medicinal ingredients may be used individually from the above list, in combination of two or more, or commercially available products may be used.

[0054] -Oily components- The oral composition of this embodiment may contain any suitable conventionally known oily components in any suitable amount. Examples of oily components include hydrocarbons such as squalane, (light) liquid paraffin, petrolatum, and microcrystalline wax; higher alcohols (e.g., alcohols with 8 to 22 carbon atoms such as lauryl alcohol, cetyl alcohol, cetostearyl alcohol, oleyl alcohol, and isostearyl alcohol); higher fatty acids (e.g., fatty acids with 8 to 22 carbon atoms such as lauric acid, myristic acid, oleic acid, and isostearic acid); vegetable oils such as olive oil, castor oil, and coconut oil; and fatty acid esters such as isopropyl myristate. The oily components may be used individually, in combination of two or more, or commercially available products may be used.

[0055] - Preservatives - The oral composition of this embodiment may contain a conventionally known, suitable preservative in a suitably appropriate amount. By including a preservative in the oral composition, preservative properties can be imparted to the oral composition.

[0056] Examples of preservatives that may be included in oral compositions include parahydroxybenzoic acid esters (e.g., methyl parahydroxybenzoate, ethyl parahydroxybenzoate, butyl parahydroxybenzoate), sodium benzoate, etc. The preservatives may be used individually, in combination of two or more, or commercially available products may be used.

[0057] -Wetting agent- The oral composition of this embodiment may contain, in an arbitrarily suitable amount, any conventionally known humectant other than component (C). By including any humectant in the oral composition, the user experience can be further improved.

[0058] As a wetting agent, sugar alcohols and polyhydric alcohols other than sugar alcohols are preferred. Examples of sugar alcohols include sugar alcohols such as sorbitol, lactitol, and reduced starch syrup; glycerin; and polyhydric alcohols such as ethylene glycol, dipropylene glycol, and butylene glycol. As a wetting agent, one of the above wetting agents may be used alone, two or more may be used in combination, and commercially available products may be used. If the oral composition contains a wetting agent, its content is preferably 1% to 70% by mass, more preferably 1% to 65% by mass, even more preferably 1% to 60% by mass, and still more preferably 3% to 60% by mass, when the total amount of the oral composition is 100% by mass.

[0059] -Abrasive- Either inorganic or organic abrasives may be used as the abrasive. Examples of inorganic abrasives include calcium hydroxide, aluminum hydroxide, trimagnesium phosphate, magnesium carbonate, calcium sulfate, bentonite, and hydroxyapatite. Examples of organic abrasives include synthetic resin-based abrasives and polymethyl methacrylate. The above abrasives may be used individually, in combination of two or more, or commercially available products may be used.

[0060] The amount of abrasive added is preferably 5.0 to 70% by mass, and more preferably 10 to 50% by mass, when the total amount of the oral composition is considered to be 100% by mass.

[0061] - Binding agent - The oral composition of this embodiment may contain a binder.

[0062] Examples of binders that can be included in oral compositions include conventionally known and suitable organic binders, such as polysaccharides, cellulosic binders (e.g., carboxymethylcellulose (CMC), hydroxyethylcellulose, hydroxypropylcellulose, hydroxypropylmethylcellulose, methylcellulose, cationized cellulose, etc., and pharmaceutically acceptable salts thereof such as their sodium salts), other polysaccharide thickeners (e.g., xanthan gum, guar gum, gellan gum, tragacanth gum, karaya gum, arabic gum, locust bean gum, carrageenan, sodium alginate), and synthetic water-soluble polymers (e.g., sodium polyacrylate, carboxyvinyl polymer, polyvinylpyrrolidone, polyvinyl alcohol, propylene glycol alginate). Furthermore, conventionally known and suitable inorganic binders may also be included. One or more of the above-exemplary binders can be included as binders, and commercially available products can also be used.

[0063] The binder content is preferably greater than 0% by mass, more preferably 0.001% by mass or more, and even more preferably 0.01% by mass or more, when the total amount of the oral composition is considered as 100% by mass. Furthermore, the binder content is preferably 11% by mass or less, and more preferably 10% by mass or less. Therefore, the binder content is preferably greater than 0% by mass and 11% by mass or less, and more preferably between 0.01% by mass and 10% by mass.

[0064] - pH adjuster - The oral composition of this embodiment may contain a conventionally known and suitable pH adjusting agent in a suitably suitable amount. By including a pH adjusting agent in the oral composition, pH stability can be provided.

[0065] Examples of pH adjusters include organic acids such as phthalic acid, citric acid, succinic acid, tartaric acid, acetic acid, fumaric acid, malic acid, and lactic acid, or their salts (e.g., sodium citrate); inorganic acids such as phosphoric acid (e.g., orthophosphoric acid), or their salts (e.g., potassium salts, sodium salts, and ammonium salts); and hydroxides such as sodium hydroxide and potassium hydroxide. Examples of inorganic salts include disodium hydrogen phosphate, sodium dihydrogen phosphate, trisodium phosphate, sodium carbonate, and sodium bicarbonate. As a pH adjuster, one of the above pH adjusters may be used alone, two or more may be used in combination, or commercially available products may be used.

[0066] The amount of pH adjuster can be such that the pH of the oral composition after the addition of the pH adjuster is preferably 5.0 to 9.0, and more preferably 5.5 to 8.5.

[0067] In this specification, the pH value refers to the value obtained 3 minutes after the start of measurement at 25°C. The pH value can be measured using, for example, a pH meter (model number Hm-30S) manufactured by Toa Denpa Kogyo Co., Ltd.

[0068] -Colorants- The oral composition of this embodiment may contain a conventionally known and suitable coloring agent in a suitably suitable amount.

[0069] Examples of colorants that may be included in an oral composition include natural pigments such as safflower red pigment, gardenia yellow pigment, gardenia blue pigment, perilla pigment, red yeast rice pigment, red cabbage pigment, carrot pigment, hibiscus pigment, cocoa pigment, spirulina blue pigment, and tamarind pigment, as well as legally approved colorants such as Red No. 2, Red No. 3, Red No. 104, Red No. 105, Red No. 106, Red No. 227, Yellow No. 4, Yellow No. 5, Green No. 3, and Blue No. 1, and riboflavin, copper chlorophyll sodium, and titanium dioxide. As colorants, one of the above colorants may be used alone, two or more may be used in combination, and commercially available products may be used. When an oral composition contains a colorant, its content is preferably 0.00001% to 3% by mass when the total amount of the oral composition is 100% by mass.

[0070] -Other optional components- The oral composition of this embodiment may contain other optional components in an optionally suitable amount.

[0071] In this embodiment, examples of other optional components that the oral composition may contain include inorganic compounds such as titanium mica, magnesium oxide, and zirconium oxide; coating agents such as hydroxyethylcellulose dimethyldiallylammonium chloride; calcium compounds such as calcium glycerophosphate; natural polymer compounds such as agar, gelatin, starch, and glucomannan; synthetic polymer compounds or copolymers thereof such as polyvinyl acetate, acrylic resin, polyurethane, polyester, polyvinyl chloride, nylon powder, and polyethylene powder; waxes such as carnauba wax, rosin, rice wax, microcrystalline wax, beeswax, and paraffin wax; higher alcohols such as cetanol and stearyl alcohol; and polyisobutylene, polybutadiene, urethane, silicone, and natural rubber.

[0072] Other optional components may be used individually, in combination of two or more, or commercially available products may be used. The content of these other optional components can be appropriately set within a range that does not interfere with the effects of the present invention.

[0073] [Dosage form] The oral composition of this embodiment can be prepared in any suitable conventional dosage form by any suitable conventional method according to the usual procedures. Examples of dosage forms include liquids (liquid bodies such as solutions, emulsions, suspensions, and syrups), semi-solids (gels, creams, pastes, etc.), and solids (tablets, particulates, capsules, films, kneads, molten solids, waxy solids, elastic solids, soft capsules, etc.). In this embodiment, the dosage form of the oral composition is preferably a liquid or a semi-solid.

[0074] The oral composition of this embodiment can be widely used in oral applications. Examples of solid dosage forms include lozenges, gummies, gums, and toothpastes. Examples of semi-solid dosage forms include toothpastes and gel toothpastes. Examples of liquid dosage forms include mouthwashes, liquid toothpastes, and oral fresheners (sprays, etc.).

[0075] In this embodiment, the pH (at 25°C) of the oral composition is preferably 5.0 to 9.0. The pH can be adjusted by adding pH adjusting agents as previously described, by changing the component composition, etc.

[0076] The oral composition of this embodiment can be adjusted to an appropriate viscosity depending on the dosage form, for example. When the dosage form is, for example, a paste, gel, or cream, the viscosity at 25°C measured with a BH viscometer is preferably 1 Pa·s to 300 Pa·s, and more preferably 20 Pa·s to 150 Pa·s.

[0077] [Method for producing oral compositions] The method for producing the oral composition of this embodiment is not particularly limited. The oral composition can be produced by any suitable conventional method known to date. Specifically, a method for producing the oral composition may involve first preparing components that dissolve in a solvent, then mixing in other insoluble components, and, if necessary, degassing by, for example, reducing pressure. Furthermore, if the oral composition is a liquid oral composition, a method for producing it may involve sequentially adding raw material components to a solvent such as purified water, stirring, and dissolving them uniformly.

[0078] The shape and material of the container in which the oral composition of this embodiment obtained in this manner can be contained are not particularly limited. Any suitable conventionally known container that is normally applied to oral compositions can be used as the container. Examples of containers that can be used include laminate containers consisting of a polyethylene layer, an ethylene methacrylic acid copolymer layer, a polyethylene terephthalate layer, an aluminum layer, a glass vapor-deposited layer, a polyvinyl alcohol layer, an ethylene vinyl alcohol copolymer layer, an acrylonitrile copolymer layer, paper, a recycled plastic layer, etc., as well as polyethylene containers, polyethylene terephthalate containers, polypropylene containers, etc., tubular containers, dispenser containers, and film packaging containers such as pillow packaging.

[0079] Specifically, if the oral composition is a toothpaste composition, it can be made into a product by, for example, housing it in a predetermined container such as a laminate tube. If the oral composition is in liquid form, i.e., a liquid oral composition such as a mouthwash or liquid toothpaste composition, the prepared liquid oral composition can be made into a product by housing it in a predetermined container such as a bottle. [Examples]

[0080] The present invention will be specifically described below with reference to examples and comparative examples. The present invention is not limited to the examples described later. Unless otherwise specified, the numerical values ​​described in these examples (including the values ​​in the table below) represent mass percent.

[0081] [Components used in the examples and comparative examples] First, we will explain the components used in the examples and comparative examples. -(A) Ingredients: Pyridoxine or its salt- (A1) Pyridoxine hydrochloride (Kyowa Pharma Chemical Co., Ltd. "Pyridoxine Hydrochloride")

[0082] -(B) Component: Inorganic powder- (B1) Abrasive silica: Zeodent 124 manufactured by EVONIK Corporation (B2) Thickening silica: "Carplex #67Q (liquid absorption capacity: 2.3)" manufactured by DSL Japan Co., Ltd. (B3) Thickening silica: "Aerosil 200 (liquid absorption capacity: 4.2)" manufactured by Nippon Aerosil Co., Ltd. (B4) Heavy calcium carbonate: "Softon 1000" manufactured by Bihoku Funka Kogyo Co., Ltd. (B5) Anhydrous calcium hydrogen phosphate: "Fujikarin" manufactured by Fuji Chemical Industry Co., Ltd. (B6) Titanium dioxide: "Typeque CR-50" manufactured by Ishihara Sangyo Co., Ltd. (B7) Aluminum Oxide: "Aluminum Oxide" manufactured by Nippon Light Metal Co., Ltd. (B8) Zinc oxide: "Zinc Oxide No. 1" manufactured by Honjo Chemical Co., Ltd.

[0083] -(C) component- (C1) Propylene glycol: "Cosmetic-grade propylene glycol" manufactured by ADEKA Corporation. (C2) Polyethylene glycol 4000: "PEG4000S" manufactured by Sanyo Chemical Industries, Ltd.

[0084] -(D) Component- (D1) Sodium saccharin: "Sodium saccharin" manufactured by Aisan Chemical Industry Co., Ltd. (D2) Xylitol: "Xylitol" manufactured by Mitsubishi Corporation Life Sciences Co., Ltd.

[0085] -(E) Component- (E1) Tocopherol acetate: "dl-α-tocopherol acetate" manufactured by DSM Nutrition Japan Co., Ltd. (E2) Tocopherol Nicotinate: "Tocopherol Nicotinate" manufactured by Eisai Food Chemical Co., Ltd.

[0086] - Optional components (components other than components (A) to (E)) 70% sorbitol: "D-Sorbitol Solution" manufactured by Mitsubishi Corporation Life Sciences Co., Ltd. Polyoxyethylene (20) hydrogenated castor oil: "Brownon RCW-20" manufactured by Aoki Oil Co., Ltd. Sodium lauryl sulfate: "TEXAPON OC-P" manufactured by BASF Japan Ltd. Sodium carboxymethylcellulose: "CMC1260" manufactured by Daicel Mirise Co., Ltd. Fragrance composition A Water (purified water)

[0087] The compositions of fragrance compositions A to S used in the examples, comparative examples, and formulation examples are shown in Tables 1 and 2 below.

[0088] [Table 1]

[0089] [Table 2]

[0090] The compositions of flavors 1 to 7 and solvents used in the above-mentioned fragrance compositions A to S are shown in Tables 3 to 10 below.

[0091] [Table 3]

[0092] [Table 4]

[0093] [Table 5]

[0094] [Table 6]

[0095] [Table 7]

[0096] [Table 8]

[0097] [Table 9]

[0098] [Table 10]

[0099] Examples 1-36 and Comparative Examples 1-6 Using the above ingredients as raw materials, toothpaste compositions having the formulations shown in Tables 11 to 16 below were prepared.

[0100] The obtained oral compositions (Examples 1-36 and Comparative Examples 1-6) were evaluated using the following evaluation method. The evaluation results are shown in Tables 11-16 below.

[0101] [Evaluation Method] (1) Evaluation of the astringent sensation of the oral mucosa during tooth brushing Ten expert panelists conducted a sensory evaluation of the presence and degree of astringency in the oral mucosa during toothbrushing. The oral compositions (toothpaste compositions) described in the previously explained examples and comparative examples, filled in laminate tubes, were extruded 1 cm onto a toothbrush and used for 3 minutes of brushing in the usual manner. The astringency felt in the oral mucosa during brushing was evaluated according to the scoring criteria shown below. The average score from the ten expert panelists was calculated and judged on a 5-point scale (A, B, C, D, and E) according to the evaluation criteria below. A score of C or higher (A, B, and C) was considered a pass. (Scoring Criteria) 5 points: I feel a very strong astringent sensation in my mouth. 4 points: I felt a strong astringent sensation in my mouth. 3 points: There is an astringent feeling in the mouth. 2 points: There is a slight astringent sensation in the mouth. 1 point: No astringent feeling in the mouth. (Evaluation Criteria) A: Average score of 4.5 points or more B: Average score of 4.0 or higher but less than 4.5 C: Average score between 3.0 and 4.0 D: Average score between 2.0 and 3.0 E: Average score between 1.0 and 2.0 points

[0102] (2) Evaluation of bitterness after brushing teeth A sensory evaluation was conducted by 10 expert panelists regarding the presence and degree of bitterness after brushing. The toothpaste compositions described in the examples and comparative examples were extruded 1 cm onto a toothbrush, and teeth were brushed for 3 minutes using the usual method. The presence and degree of bitterness felt in the mouth after brushing were evaluated according to the scoring criteria shown below. The average score from the 10 expert panelists was calculated and judged on a four-level scale (A, B, C, and D) according to the evaluation criteria below. A score of B or higher (A and B) was considered a pass. (Scoring Criteria) 4 points: No bitterness at all. 3 points: Slightly bitter taste. 2 points: I can taste bitterness. 1 point: I find the bitterness to be very strong. (Evaluation Criteria) A: Average score of 3.5 points or more B: Average score between 3.0 and 3.5 points C: Average score between 2.0 and 3.0 D: Average score between 1.0 and 2.0 points

[0103] (3) Evaluation of the stability of pyridoxine hydrochloride during low-temperature storage Using the measurement method described later, the pyridoxine hydrochloride content of the oral composition immediately after preparation (initial value) and the pyridoxine hydrochloride content after storage at -5°C for one month (evaluation sample value) were measured, and the stability of pyridoxine hydrochloride in the oral composition during low-temperature storage was evaluated from the remaining pyridoxine hydrochloride content.

[0104] (Measurement method) The pyridoxine hydrochloride content was measured by taking 2.5 g of the oral composition for each example, extracting the pyridoxine hydrochloride contained in the oral composition with 80% ethanol, and then quantifying the pyridoxine hydrochloride using the absolute calibration curve method by HPLC (high-performance liquid chromatography) under the equipment and test conditions described below. The residual rate of pyridoxine hydrochloride was calculated using the formula below, and the stability of pyridoxine hydrochloride during low-temperature storage was evaluated on a four-point scale (A, B, C, and D) according to the evaluation criteria below. Products receiving a rating of B or higher (A and B) were deemed acceptable. Formula: Percentage of pyridoxine hydrochloride remaining (%) = {Evaluation sample value (%) / Initial value (%)} × 100

[0105] (Equipment used) • Pump: Shimadzu Corporation "LC-20AD" • Sample introduction unit: Shimadzu Corporation "SIL-20AC" • Detector: Shimadzu Corporation "SPD-20A" • Column thermostat: Shimadzu Corporation "CTO-20AC" ·Eluent flow rate: 1mL / min (Test conditions) • Detector: UV absorbance spectrophotometer (measurement wavelength: 290 nm) • Column: TSKgel ODS-100V 5μm Column temperature: 40°C • Eluent: 1% acetic acid, 15% acetonitrile solution (Evaluation Criteria) A: Over 95% B: 90% or more but less than 95% C: 85% to less than 90% D: Less than 85%

[0106] (4) Evaluation of sarcastic remarks while brushing teeth A sensory evaluation was conducted by 10 expert panelists to assess the presence and degree of unpleasantness during toothbrushing. The toothpaste compositions described in the previously mentioned examples and comparative examples were extruded 1 cm onto a toothbrush and used for 3 minutes of normal brushing. The presence and degree of unpleasantness felt during brushing were then evaluated according to the following scoring criteria. The average score from the 10 expert panelists was calculated and judged on a 5-point scale (A, B, C, D, and E) according to the evaluation criteria below. A score of C or higher (A, B, and C) was considered a pass. (Scoring Criteria) 4 points: Not offensive at all. 3 points: Almost no sarcasm. 2 points: Slightly sarcastic. 1 point: It's sarcastic. (Evaluation Criteria) A: 4.0 points B: 3.5 points or higher, less than 4.0 points C: 3.0 points or higher, less than 3.5 points D: 2.0 points or higher, less than 3.0 points E: Less than 2.0 points

[0107] [Table 11]

[0108] [Table 12]

[0109] [Table 13]

[0110] [Table 14]

[0111] [Table 15]

[0112] [Table 16]

[0113] Examples 1 to 36, which used predetermined amounts of components (A) and (B), showed good evaluation of the astringent sensation of the oral mucosa during brushing and reduced bitterness after brushing. Furthermore, Examples 16 to 36, which further included component (C), improved the stability of pyridoxine hydrochloride during low-temperature storage. Examples 23 to 36, which further included either or both of components (D) and (E), effectively reduced bitterness after brushing, and in particular, when both components (D) and (E) were included, the unpleasant taste during brushing was further reduced. On the other hand, Comparative Examples 1 to 6, which did not satisfy any of the requirements of the present invention, were inferior in at least one of the astringent sensation of the oral mucosa during brushing and bitterness after brushing.

[0114] (Example prescription) Examples of oral compositions to which the present invention is applied are shown below. In each example of a formulation, the unit of the numerical value indicated as the content is "mass%".

[0115] In the following prescription examples 1-43, both the astringent sensation in the oral mucosa during use and the bitter taste after use were well-received.

[0116] Formulation Example 1: Toothpaste Composition Pyridoxine hydrochloride 0.5 Polishable silica*1 10 Thickening silica*2 3 Titanium dioxide 0.4 Propylene glycol 4 Sodium saccharin 0.2 Sodium fluoride 0.32 Sodium polyphosphate 1 Sodium lauryl sulfate 1.5 Sodium lauroyl sarcosinate 0.1 Polyoxyethylene (20) hydrogenated castor oil 0.5 Coconut oil fatty acid amidopropyl betaine solution*3 0.5 Sodium bicarbonate 0.2 70% sorbitol solution 25 Xanthan gum 1.6 Sodium polyacrylate 0.2 Methylparaben 0.2 Sodium hydroxide (48% solution) 0.2 Fragrance composition A 1.2 Water balance Total 100 *1 Abrasive silica: Zeodent 124 manufactured by EVONIK Corporation *2 Thickening silica: "Carplex #67Q (liquid absorption capacity 2.3)" manufactured by DSL Japan Co., Ltd. *3 Coconut oil fatty acid amidopropyl betaine solution: A 30% pure solution was used, and the amount of the solution used is indicated.

[0117] Formulation Example 2: Toothpaste Composition Pyridoxine hydrochloride 0.5 Polishable silica*1 11 Thickening silica*2 1 Titanium dioxide 0.4 Aluminum Oxide 2 Propylene glycol 3 Polyethylene glycol 400 2.5 Sodium saccharin 0.2 Sodium fluoride 0.32 Sodium pyrophosphate 0.5 Sodium lauryl sulfate 1 Sodium lauroyl sarcosinate 0.1 Polyoxyethylene (20) hydrogenated castor oil 1 Sodium bicarbonate 0.5 70% sorbitol solution 30 Xanthan gum 0.8 Sodium polyacrylate 0.5 Methylparaben 0.2 Sodium hydroxide (48% solution) 0.2 Fragrance composition A 1.2 Water balance Total 100 *1 Abrasive silica: Zeodent 124 manufactured by EVONIK Corporation *2 Thickening silica: "Carplex #67Q (liquid absorption capacity 2.3)" manufactured by DSL Japan Co., Ltd.

[0118] Formulation Example 3: Toothpaste Composition Pyridoxine hydrochloride 0.5 Heavy calcium carbonate 10 Thickening silica*1 2 Aluminum Oxide 1 Polyethylene glycol 400 1 Propylene glycol 3 Sodium saccharin 0.1 Mannitol 0.5 Stannous fluoride 0.6 Sodium lauryl sulfate 1.5 70% sorbitol solution 20 Sodium carboxymethylcellulose*2 1 Methylparaben 0.2 Fragrance composition A 1 Water balance Total 100 *1 Thickening silica: "Carplex #67Q (liquid absorption capacity 2.3)" manufactured by DSL Japan Co., Ltd. *2 Sodium carboxymethylcellulose: "CMC1260" manufactured by Daicel Mirise Co., Ltd.

[0119] Formulation Example 4: Toothpaste Composition Pyridoxine hydrochloride 0.5 Heavy calcium carbonate 10 Thickening silica*4 2 Propylene glycol 3 Sodium saccharin 0.2 Sucralose 0.002 Sodium monofluorophosphate 1.1 Sodium lauryl sulfate 1.8 70% sorbitol solution 25 Sodium carboxymethylcellulose*1 0.6 Sodium carboxymethylcellulose*2 0.2 Sodium carboxymethylcellulose*3 0.4 Sodium polyacrylate 0.2 Methylparaben 0.2 Fragrance composition A 1 Water balance Total 100 *1 Thickening silica: "Carplex #67Q (liquid absorption capacity 2.3)" manufactured by DSL Japan Co., Ltd. *2 Sodium carboxymethylcellulose: "CMC1260" manufactured by Daicel Mirise Co., Ltd. *3 Sodium carboxymethylcellulose: "CMC1250" manufactured by Daicel Mirise Co., Ltd. *4 Carboxymethylcellulose sodium: "CMC1220" manufactured by Daicel Mirise Co., Ltd.

[0120] Formulation Example 5: Toothpaste Composition Pyridoxine hydrochloride 0.5 Heavy calcium carbonate 5 Aluminum oxide 0.4 Thickening silica*1 5.5 Titanium dioxide 0.5 Propylene glycol 3 Sodium saccharin 0.2 Xylitol 7 Mannitol 0.3 Sodium monofluorophosphate 1.1 Sodium lauryl sulfate 2 Sodium lauroyl sarcosinate 0.1 70% sorbitol solution 25 Sodium carboxymethylcellulose*2 1.5 Methylparaben 0.2 Fragrance composition A 1.5 Water balance Total 100 *1 Thickening silica: "Carplex #67Q (liquid absorption capacity 2.3)" manufactured by DSL Japan Co., Ltd. *2 Sodium carboxymethylcellulose: "CMC1260" manufactured by Daicel Mirise Co., Ltd.

[0121] Formulation Example 6: Toothpaste Composition Pyridoxine hydrochloride 0.5 Polishable silica*1 8 Thickening silica*2 5 Titanium dioxide 0.4 Propylene glycol 3 Polyethylene glycol 4000 0.2 Sodium saccharin 0.15 Mannitol 0.2 Sucralose 0.02 Sodium fluoride 0.32 Sodium tetradecenesulfonate 0.3 Sodium lauryl sulfate 0.3 Polyoxyethylene (20) hydrogenated castor oil 1.5 Coconut oil fatty acid amidopropyl betaine 1.5 70% sorbitol solution 40 Xanthan gum 0.5 Sodium alginate 0.5 Sodium polyacrylate 0.2 Hydroxyethylcellulose Dimethyldiallylammonium chloride 0.05 Benzalkonium chloride 0.01 Fragrance composition A 1 Water balance Total 100 *1 Abrasive silica: Zeodent 124 manufactured by EVONIK Corporation *2 Thickening silica: "Carplex #67Q (liquid absorption capacity 2.7)" manufactured by DSL Japan Co., Ltd.

[0122] Formulation Example 7: Toothpaste Composition Pyridoxine hydrochloride 0.5 Polishable silica*2 8 Thickening silica*3 5 Titanium dioxide 1 Propylene glycol 3 Polyethylene glycol #4000 1 Sodium saccharin 0.2 Mannitol 0.2 Sodium fluoride 0.32 Dextranase*1 0.2 (Enzyme activity per gram of preparation: 20 U) Sodium polyphosphate 0.5 Sodium lauryl sulfate 0.7 Sodium tetradecenesulfonate 0.3 Sodium lauroyl sarcosinate 0.2 Polyoxyethylene (20) hydrogenated castor oil 1 Polyoxyethylene (5) stearyl ether 1 Decaglycerin fatty acid ester 0.2 Coconut oil fatty acid amidopropyl betaine 2 70% sorbitol solution 40 Xanthan gum 0.5 Carrageenan 0.5 Sodium alginate 0.2 Hydroxyethylcellulose Dimethyldiallylammonium chloride 0.05 DL-Alanine 0.15 Fragrance composition A 1.3 Water balance Total 100 *1 Dextranase: Dextranase 2F (enzyme activity 4000 U / g) manufactured by Mitsubishi Chemical Corporation. *2 Abrasive silica: Zeodent 124 manufactured by EVONIK Corporation *3 Thickening silica: "Carplex #67Q (liquid absorption capacity 2.7)" manufactured by DSL Japan Co., Ltd.

[0123] Formulation Example 8: Toothpaste Composition Pyridoxine hydrochloride 0.5 Polishable silica*2 10 Thickening silica*3 1 Thickening silica*4 2 Titanium dioxide 0.4 Propylene glycol 5 Sodium saccharin 0.1 Mannitol 0.5 Tocopherol acetate 0.1 Sodium fluoride 0.32 Dextranase*1 0.2 (Enzyme activity per gram of preparation: 20 U) Potassium nitrate 5 Sodium lauryl sulfate 0.5 Sodium lauroyl sarcosinate 0.1 Sodium tetradecenesulfonate 0.5 Polyoxyethylene (20) hydrogenated castor oil 2 Polyoxyethylene(5) stearyl ether 1.5 Decaglycerin fatty acid ester 0.1 Coconut oil fatty acid amidopropyl betaine 2 70% sorbitol solution 45 Xanthan gum 1 Sodium alginate 0.8 Sodium polyacrylate 0.6 Hydroxyethylcellulose Dimethyldiallylammonium chloride 1 Sodium pyrrolidonecarboxylate 3 DL-Alanine 0.1 Fragrance composition A 1.3 Water balance Total 100 *1 Dextranase: Dextranase 2F (enzyme activity 4000 U / g) manufactured by Mitsubishi Chemical Corporation. *2 Abrasive silica: Zeodent 124 manufactured by EVONIK Corporation *3 Thickening silica: "Carplex #67Q (liquid absorption capacity 2.7)" manufactured by DSL Japan Co., Ltd. *4 Thickening silica: "Aerosil 200 (liquid absorption capacity 4.2)" manufactured by Nippon Aerosil Co., Ltd.

[0124] Formulation Example 9: Toothpaste Composition Pyridoxine hydrochloride 1 Polishable silica*2 10 Thickening silica*3 2 Thickening silica*4 0.5 Titanium dioxide 0.4 Propylene glycol 5 Sodium saccharin 0.12 Xylitol 3 Mannitol 0.3 Tocopherol acetate 0.1 Sodium fluoride 0.32 Potassium nitrate 5 Dextranase*1 0.2 (Enzyme activity per gram of preparation: 20 U) Sodium lauroyl sarcosinate 0.1 Sodium tetradecenesulfonate 1 Polyoxyethylene (20) hydrogenated castor oil 2.5 Polyoxyethylene(5) stearyl ether 1.5 Decaglycerin fatty acid ester 0.1 Coconut oil fatty acid amidopropyl betaine 1 70% sorbitol solution 45 Xanthan gum 1.5 Sodium alginate 0.2 Sodium polyacrylate 0.2 Hydroxyethylcellulose Dimethyldiallylammonium chloride 0.1 DL-Alanine 0.2 Fragrance composition A 1.3 Water balance Total 100 *1 Dextranase: Dextranase 2F (enzyme activity 4000 U / g) manufactured by Mitsubishi Chemical Corporation. *2 Abrasive silica: Zeodent 124 manufactured by EVONIK Corporation *3 Thickening silica: "Carplex #67Q (liquid absorption capacity 2.7)" manufactured by DSL Japan Co., Ltd. *4 Thickening silica: "Aerosil 200 (liquid absorption capacity 4.2)" manufactured by Nippon Aerosil Co., Ltd.

[0125] Formulation Example 10: Toothpaste Composition Pyridoxine hydrochloride 0.5 Polishable silica*1 10 Thickening silica*2 4 Titanium dioxide 0.1 Propylene glycol 3 Polyethylene glycol 4000 0.5 Sodium fluoride 0.32 β-Glycyrrhetinic acid 0.01 Isopropylmethylphenol 0.1 Sodium saccharin 0.2 Sodium lauryl sulfate 1.4 Sodium lauroyl sarcosinate 0.2 Polyoxyethylene (20) hydrogenated castor oil 0.5 Polyoxyethylene (5) stearyl ether 0.5 70% sorbitol solution 35 Xanthan gum 0.7 Sodium alginate 0.3 Sodium polyacrylate 0.5 Fragrance composition A 1.3 Water balance Total 100 *1 Abrasive silica: Zeodent 124 manufactured by EVONIK Corporation *2 Thickening silica: "Carplex #67Q (liquid absorption capacity 2.4)" manufactured by DSL Japan Co., Ltd.

[0126] Formulation Example 11: Toothpaste Composition Pyridoxine hydrochloride 0.5 Polishable silica*1 15 Thickening silica*2 5 Titanium dioxide 0.4 Sodium saccharin 0.18 Xylitol 0.5 Sodium fluoride 0.32 β-Glycyrrhetinic acid 0.01 Isopropylmethylphenol 0.05 Sodium lauryl sulfate 1.2 Polyoxyethylene (20) hydrogenated castor oil 0.75 Polyoxyethylene(5) stearyl ether 0.75 70% sorbitol solution 35 Sodium carboxymethylcellulose*3 1.4 Sodium polyacrylate 0.4 Fragrance composition A 1.2 Water balance Total 100 *1 Abrasive silica: Zeodent 124 manufactured by EVONIK Corporation *2 Thickening silica: "Carplex #67Q (liquid absorption capacity 2.4)" manufactured by DSL Japan Co., Ltd. *3 Sodium carboxymethylcellulose: "CMC1260" manufactured by Daicel Mirise Co., Ltd.

[0127] Formulation Example 12: Toothpaste Composition Pyridoxine hydrochloride 0.5 Polishable silica*1 10 Thickening silica*2 3 Titanium dioxide 0.05 Propylene glycol 3 Polyethylene glycol 4000 0.5 Sodium saccharin 0.18 Tocopherol acetate 0.2 Sodium fluoride 0.32 Tranexamic acid 0.05 Isopropylmethylphenol 0.05 Sodium lauroyl methyl taurate 0.6 Sodium lauryl sulfate 0.2 Polyoxyethylene(5) hydrogenated castor oil 1.5 Coconut oil fatty acid amide propyl betaine 0.3 85% Glycerin 40 Xanthan gum 0.5 Sodium carboxymethyl cellulose*3 1.5 Sodium polyacrylate 0.3 Citric acid 0.5 Sodium citrate 0.5 Sodium sulfate anhydrous 0.5 Fragrance composition A 1.3 Water balance<000090​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​Sodium lauroyl methyl taurate 0.8 Sodium lauryl sulfate 0.1 Polyoxyethylene (5) hydrogenated castor oil 1.5 Coconut oil fatty acid amidopropyl betaine 0.6 85% Glycerin 20 70% sorbitol solution 20 Xanthan gum 0.2 Sodium carboxymethylcellulose*3 1.8 Sodium polyacrylate 0.3 Citric acid 0.5 Sodium citrate 0.5 Anhydrous sodium sulfate 1 Fragrance composition A 1.3 Water balance Total 100 *1 Abrasive silica: Zeodent 124 manufactured by EVONIK Corporation *2 Thickening silica: "Carplex #67Q (liquid absorption capacity 2.3)" manufactured by DSL Japan Co., Ltd. *3 Sodium carboxymethylcellulose: "CMC1260" manufactured by Daicel Mirise Co., Ltd.

[0129] Formulation Example 14: Toothpaste Composition Pyridoxine hydrochloride 2 Polishable silica*1 8 Titanium dioxide 0.5 Thickening silica*3 6 Sodium saccharin 0.18 Tocopherol acetate 0.1 Sodium fluoride 0.32 Potassium nitrate 5 Tranexamic acid 0.05 Isopropylmethylphenol 0.05 Sodium lauroyl methyl taurate 0.7 Polyoxyethylene (5) hydrogenated castor oil 2 Coconut oil fatty acid amidopropyl betaine 1 70% sorbitol solution 40 Sodium carboxymethyl cellulose *2 2 Xanthan gum 0.5 Citric acid 0.25 Sodium citrate 0.5 Fragrance composition A 1.3 Methylparaben 0.2 Water balance Total 100 *1 Abrasive silica: "Zeodent 124" manufactured by EVONIK Corporation *2 Viscosity - increasing silica: "Carplex #67Q (liquid absorption amount 2.3)" manufactured by DSL Japan Co., Ltd. *3 Sodium carboxymethyl cellulose: "CMC1260" manufactured by Daicel Miraiz Co., Ltd.

[0130] Formulation example 15: Toothpaste composition Pyridoxine hydrochloride 1 Abrasive silica *1 12 Viscosity - increasing silica *2 2 Titanium oxide 0.4 Saccharin sodium 0.15 Tocopherol acetate 0.1 Sodium fluoride 0.32 Sodium polyphosphate 1 Tranexamic acid 0.05 Isopropylmethylphenol 0.05 Sodium lauroyl methyl taurine 1.5 Polyoxyethylene (5) hydrogenated castor oil 1.5 Coconut oil fatty acid amide propyl betaine 2 70% Sorbitol solution 50 Sodium carboxymethyl cellulose *3 1.5 Sodium polyacrylate 0.5 Fragrance composition A 1.3 Methylparaben 0.2 Sodium sulfate anhydrous 1 Water balance Total 100 *1 Abrasive silica: "Zeodent 124" manufactured by EVONIK Corporation *2 Thickening silica: "Carplex #67Q (liquid absorption capacity 2.3)" manufactured by DSL Japan Co., Ltd. *3 Sodium carboxymethylcellulose: "CMC1260" manufactured by Daicel Mirise Co., Ltd.

[0131] Formulation Example 16: Toothpaste Composition Pyridoxine hydrochloride 0.5 Polishable silica*1 10 Thickening silica*2 5 Sodium saccharin 0.15 Tocopherol acetate 0.1 Sodium fluoride 0.32 Tranexamic acid 0.05 Potassium nitrate 5 Isopropylmethylphenol 0.05 Sodium polyphosphate 1 Sodium lauroyl methyl taurate 0.2 Polyoxyethylene (5) hydrogenated castor oil 1.5 Coconut oil fatty acid amidopropyl betaine 1 70% sorbitol solution 40 Sodium carboxymethylcellulose*3 1.4 Xanthan gum 0.5 Citric acid 0.25 Sodium citrate 0.5 Titanium mica 0.5 Yellow No. 5 0.00025 Fragrance composition A 1.3 Methylparaben 0.15 Water balance Total 100 *1 Abrasive silica: Zeodent 124 manufactured by EVONIK Corporation *2 Thickening silica: "Carplex #67Q (liquid absorption capacity 2.3)" manufactured by DSL Japan Co., Ltd. *3 Sodium carboxymethylcellulose: "CMC1260" manufactured by Daicel Mirise Co., Ltd.

[0132] Formulation Example 17: Toothpaste Composition Pyridoxine hydrochloride 1 Polishable silica*1 7 Thickening silica*2 7 Titanium dioxide 0.05 Propylene glycol 3 Sodium saccharin 0.2 Tocopherol acetate 0.1 Sodium fluoride 0.32 Tranexamic acid 0.05 Potassium nitrate 5 Isopropylmethylphenol 0.05 Sodium pyrophosphate 0.5 Sodium lauroyl methyl taurate 1 Polyoxyethylene (5) hydrogenated castor oil 1.5 Coconut oil fatty acid amidopropyl betaine 2.5 85% Glycerin 30 Propylene glycol alginate 0.1 Xanthan gum 0.4 Sodium carboxymethylcellulose*3 1.2 Sodium polyacrylate 0.3 Titanium mica 0.5 Fragrance composition A 1 Water balance Total 100 *1 Abrasive silica: Zeodent 124 manufactured by EVONIK Corporation *2 Thickening silica: "Carplex #67Q (liquid absorption capacity 2.3)" manufactured by DSL Japan Co., Ltd. *3 Sodium carboxymethylcellulose: "CMC1260" manufactured by Daicel Mirise Co., Ltd.

[0133] Formulation Example 18: Toothpaste Composition Pyridoxine hydrochloride 0.5 Heavy calcium carbonate 10 Thickening silica*1 4 Propylene glycol 4 Polyethylene glycol 4000 0.5 Sodium saccharin 0.1 Xylitol 5 Mannitol 0.1 Tocopherol acetate 0.1 Sodium monofluorophosphate 1.1 β-Glycyrrhetinic acid 0.02 Tranexamic acid 0.05 Sodium lauryl sulfate 0.8 Sodium lauroyl sarcosinate 0.1 Polyoxyethylene (20) hydrogenated castor oil 1 Polyoxyethylene (5) stearyl ether 1 Benzalkonium chloride 0.01 Sodium carboxymethylcellulose*2 1 Sodium polyacrylate 0.3 70% sorbitol solution 55 Scutellaria baicalensis extract 0.005 Carrot extract 0.001 Phellodendron bark extract 0.05 Rosemary extract 0.001 Sage extract 0.001 Tea extract 0.001 Fragrance composition A 1 Water balance Total 100 *1 Thickening silica: "Carplex #67Q (liquid absorption capacity 2.3)" manufactured by DSL Japan Co., Ltd. *2 Sodium carboxymethylcellulose: "CMC1260" manufactured by Daicel Mirise Co., Ltd.

[0134] Formulation Example 19: Toothpaste Composition Pyridoxine hydrochloride 0.5 Polishable silica*1 10 Thickening silica*2 3 Titanium dioxide 1 Propylene glycol 5 Polyethylene glycol 4000 1 Sodium saccharin 0.1 Tocopherol acetate 0.1 Sodium monofluorophosphate 1.1 Aluminum lactate 2 Isopropylmethylphenol 0.1 Tranexamic acid 0.1 Potassium nitrate 5 Sodium chloride 1 Sodium lauroyl methyl taurate 1 Polyoxyethylene (20) hydrogenated castor oil 0.6 Polyoxyethylene(5) stearyl ether 0.6 Coconut oil fatty acid amidopropyl betaine solution*3 1 70% sorbitol solution 32 Xanthan gum 0.3 Carrageenan 0.9 Sodium alginate 0.9 Sodium hydroxide 0.1 Sodium dihydrogen phosphate 1 Methylparaben 0.2 Fragrance composition A 1.5 Water balance Total 100 *1 Abrasive silica: Zeodent 124 manufactured by EVONIK Corporation *2 Thickening silica: "Carplex #67Q (liquid absorption capacity 2.3)" manufactured by DSL Japan Co., Ltd. *3 Coconut oil fatty acid amidopropyl betaine solution: A 30% pure solution was used, and the amount of the solution used is indicated.

[0135] Formulation Example 20: Toothpaste Composition Pyridoxine hydrochloride 0.5 Polishable silica*1 10 Thickening silica*2 4 Titanium dioxide 0.1 Propylene glycol 3 Polyethylene glycol 4000 0.1 Sodium saccharin 0.1 Tocopherol acetate 0.1 Sodium monofluorophosphate 1.1 Isopropylmethylphenol 0.1 Tranexamic acid 0.05 Copper gluconate 0.1 Sodium lauryl sulfate 1.5 Sodium lauroyl sarcosinate 0.2 Sodium lauroyl methyl taurate 1.2 Polyoxyethylene (20) hydrogenated castor oil 1.5 Polyoxyethylene(5) stearyl ether 1.5 Coconut oil fatty acid amidopropyl betaine solution*3 1 85% Glycerin 45 Xanthan gum 0.5 Sodium carboxymethylcellulose*4 1 Sodium hydroxide 0.1 Methylparaben 0.2 Fragrance composition A 1.5 Water balance Total 100 *1 Abrasive silica: Zeodent 124 manufactured by EVONIK Corporation *2 Thickening silica: "Carplex #67Q (liquid absorption capacity 2.3)" manufactured by DSL Japan Co., Ltd. *3 Coconut oil fatty acid amidopropyl betaine solution: A 30% pure solution was used, and the amount of the solution used is indicated. *4 Carboxymethylcellulose sodium: "CMC1260" manufactured by Daicel Mirise Co., Ltd.

[0136] Formulation Example 21: Toothpaste Composition Pyridoxine hydrochloride 0.5 Polishable silica*1 12 Thickening silica*2 2 Titanium dioxide 0.4 Aluminum oxide 0.5 Propylene glycol 3 Sodium saccharin 0.1 Xylitol 8 Sodium fluoride 0.32 Sodium lauryl sulfate 1.4 70% sorbitol solution 32 Xanthan gum 0.55 Sodium polyacrylate 0.55 Methylparaben 0.1 Fragrance composition A 1 Water balance Total 100 *1 Abrasive silica: Zeodent 124 manufactured by EVONIK Corporation *2 Thickening silica: "Carplex #67Q (liquid absorption capacity 2.3)" manufactured by DSL Japan Co., Ltd.

[0137] Formulation Example 22: Toothpaste Composition Pyridoxine hydrochloride 0.5 Polishable silica*1 10 Thickening silica*2 4 Aluminum oxide 0.5 Propylene glycol 7 Sodium saccharin 0.18 Sucralose 0.1 Sodium fluoride 0.32 Sodium lauroyl sarcosinate 0.2 Sodium lauryl sulfate 1.7 Polyoxyethylene (20) hydrogenated castor oil 0.3 Xanthan gum 0.5 Sodium polyacrylate 1.5 70% sorbitol solution 35 Methylparaben 0.18 Fragrance composition A 1.4 Water balance Total 100 *1 Abrasive silica: Zeodent 124 manufactured by EVONIK Corporation *2 Thickening silica: "Carplex #67Q (liquid absorption capacity 2.3)" manufactured by DSL Japan Co., Ltd.

[0138] Formulation Example 23: Toothpaste Composition Pyridoxine hydrochloride 1 Polishable silica*1 12 Titanium dioxide 0.5 Propylene glycol 4 Sodium saccharin 0.18 Xylitol 0.8 Sodium fluoride 0.32 Sodium lauroyl sarcosinate 0.2 Sodium lauryl sulfate 1.2 Polyoxyethylene (20) hydrogenated castor oil 0.5 Coconut oil fatty acid amidopropyl betaine solution*3 0.8 Sodium alginate 0.2 Xanthan gum 1.6 Sodium polyacrylate 0.3 70% sorbitol solution 40 Methylparaben 0.18 Fragrance composition A 1.3 Water balance Total 100 *1 Abrasive silica: Zeodent 124 manufactured by EVONIK Corporation *2 Thickening silica: "Carplex #67Q (liquid absorption capacity 2.3)" manufactured by DSL Japan Co., Ltd. *3 Coconut oil fatty acid amidopropyl betaine solution: A 30% pure solution was used, and the amount of the solution used is indicated.

[0139] Formulation Example 24: Toothpaste Composition Pyridoxine hydrochloride 0.5 Thickening silica*1 5 Propylene glycol 5 Polyethylene glycol 4000 1 Sodium saccharin 0.05 Tocopherol acetate 1 Sodium fluoride 0.32 Tranexamic acid 0.05 Isopropylmethylphenol 0.1 Dipotassium glycyrrhizinate 0.15 Sodium lauroyl sarcosinate 0.2 Sodium lauryl sulfate 1.8 Polyoxyethylene (5) hydrogenated castor oil 2.5 70% sorbitol solution 55 Sodium alginate 0.6 Xanthan gum 0.9 Sodium polyacrylate 0.5 Anhydrous sodium sulfate 0.5 Fragrance composition A 1 Water balance Total 100 *1 Thickening silica: "Carplex #67Q (liquid absorption capacity 2.3)" manufactured by DSL Japan Co., Ltd.

[0140] Formulation Example 25: Toothpaste Composition Pyridoxine hydrochloride 0.5 Polishable silica*1 10 Thickening silica*2 4.5 Titanium dioxide 0.4 Propylene glycol 3 Polyethylene glycol 4000 2 Sodium saccharin 0.16 Tocopherol acetate 0.5 Sodium fluoride 0.32 Tranexamic acid 0.05 Isopropylmethylphenol 0.07 Dipotassium glycyrrhizinate 0.12 Sodium lauroyl sarcosinate 0.2 Sodium lauroyl methyl taurate 0.5 Sodium lauryl sulfate 0.5 Polyoxyethylene (5) hydrogenated castor oil 1.5 70% sorbitol solution 50 Sodium alginate 0.2 Xanthan gum 1 Sodium polyacrylate 0.5 Methylparaben 0.2 Fragrance composition A 0.9 Water balance Total 100 *1 Abrasive silica: Zeodent 124 manufactured by EVONIK Corporation *2 Thickening silica: "Carplex #67Q (liquid absorption capacity 2.3)" manufactured by DSL Japan Co., Ltd.

[0141] Formulation Example 26: Toothpaste Composition Pyridoxine hydrochloride 0.5 Thickening silica*1 1.5 Thickening silica*2 1.5 Polishable silica*3 10 Propylene glycol 5 Polyethylene glycol 4000 3 Sodium saccharin 0.03 Tocopherol acetate 0.1 Sodium fluoride 0.32 Isopropylmethylphenol 0.1 Tranexamic acid 0.05 Sodium lauroyl sarcosinate 0.2 Sodium lauroyl methyl taurate 0.4 Polyoxyethylene (20) hydrogenated castor oil 2 Polyoxyethylene (5) stearyl ether 2 70% sorbitol solution 45 Sodium alginate 0.6 Xanthan gum 1.2 Sodium polyacrylate 0.3 Hydroxyethylcellulose Dimethyldiallylammonium chloride 0.05 Sodium pyrrolidonecarboxylate 6 Citric acid 0.2 Sodium citrate 0.4 Fragrance composition A 1.8 Water balance Total 100 *1 Thickening silica: "Carplex #67Q (liquid absorption capacity 2.3)" manufactured by DSL Japan Co., Ltd. *2 Thickening silica: "Aerosil 200 (liquid absorption capacity 4.2)" manufactured by Nippon Aerosil Co., Ltd. *3 Abrasive silica: EVONIK Co., Ltd. Zeodent 124

[0142] Formulation Example 27: Toothpaste Composition Pyridoxine hydrochloride 0.5 Polishable silica*1 10 Thickening silica*2 3 Titanium dioxide 0.4 Propylene glycol 3 Polyethylene glycol 400 1 Sodium saccharin 0.06 Tocopherol acetate 0.15 Sodium fluoride 0.32 Isopropylmethylphenol 0.1 Tranexamic acid 0.05 Dipotassium glycyrrhizinate 0.035 Sodium chloride 8 Potassium nitrate 5 Sodium polyphosphate 0.5 Allantoin 0.1 Sodium lauroyl sarcosinate 0.2 Sodium lauryl sulfate 1.5 Polyoxyethylene (5) hydrogenated castor oil 0.5 70% sorbitol solution 30 Xanthan gum 2 Sodium polyacrylate 0.5 Sodium citrate 0.5 Methylparaben 0.18 Sodium hydroxide (48% solution) 0.2 Fragrance composition A 1.6 Water balance Total 100 *1 Thickening silica: "Carplex #67Q (liquid absorption capacity 2.3)" manufactured by DSL Japan Co., Ltd. *2 Thickening silica: "Aerosil 200 (liquid absorption capacity 4.2)" manufactured by Nippon Aerosil Co., Ltd.

[0143] Formulation Example 28: Toothpaste Composition Pyridoxine hydrochloride 0.5 Thickening silica*1 3 Thickening silica*2 3 Propylene glycol 3 Polyethylene glycol 4000 1 Sodium saccharin 0.08 Tocopherol acetate 0.1 Sodium fluoride 0.32 Isopropylmethylphenol 0.1 Tranexamic acid 0.05 Sodium lauroyl sarcosinate 0.2 Sodium lauryl sulfate 1.2 Polyoxyethylene (20) hydrogenated castor oil 1.25 Polyoxyethylene(5) stearyl ether 1.25 70% sorbitol solution 55 Xanthan gum 1.5 Sodium alginate 0.3 Anhydrous sodium sulfate 2 Isostearic acid 0.2 Methylparaben 0.2 Fragrance composition A 1.2 Water balance Total 100 *1 Thickening silica: "Carplex #67Q (liquid absorption capacity 2.3)" manufactured by DSL Japan Co., Ltd. *2 Thickening silica: "Aerosil 200 (liquid absorption capacity 4.2)" manufactured by Nippon Aerosil Co., Ltd.

[0144] Formulation Example 29: Toothpaste Composition Pyridoxine hydrochloride 1.5 Polishable silica*1 10 Thickening silica*2 3 Titanium dioxide 0.3 Propylene glycol 3 Polyethylene glycol 4000 0.3 Sodium saccharin 0.18 Xylitol 0.01 Sucralose 0.01 Mannitol 0.01 Tocopherol acetate 0.1 Sodium fluoride 0.32 Isopropylmethylphenol 0.05 Allantoin 0.1 Tranexamic acid 0.05 Hinokitiol 0.1 Sodium lauroyl methyl taurate 0.6 Sodium lauryl sulfate 0.2 Polyoxyethylene (20) hydrogenated castor oil 1 Coconut oil fatty acid amidopropyl betaine*3 0.5 85% Glycerin 50 Propylene glycol alginate 0.1 Sodium alginate 0.8 Xanthan gum 1 Citric acid 0.6 Sodium citrate 0.6 Fragrance composition A 1.3 Water balance Total 100 *1 Abrasive silica: Zeodent 124 manufactured by EVONIK Corporation *2 Thickening silica: "Carplex #67Q (liquid absorption capacity 2.3)" manufactured by DSL Japan Co., Ltd. *3 Coconut oil fatty acid amidopropyl betaine solution: A 30% pure solution was used, and the amount of the solution used is indicated.

[0145] Formulation Example 30: Toothpaste Composition Pyridoxine hydrochloride 1 Polishable silica*1 10 Thickening silica*2 4 Titanium dioxide 0.4 Propylene glycol 3 Polyethylene glycol 4000 0.1 Sodium saccharin 0.16 Tocopherol acetate 0.1 Sodium fluoride 0.32 Isopropylmethylphenol 0.05 Sodium polyphosphate 1 Tranexamic acid 0.05 Sodium lauroyl methyl taurate 1.2 Polyoxyethylene (20) hydrogenated castor oil 1.25 Polyoxyethylene(5) stearyl ether 1.25 70% sorbitol solution 48 Propylene glycol alginate 0.5 Sodium carboxymethylcellulose*3 1.2 Sodium polyacrylate 0.5 Phytosteryl isostearate 0.1 Isostearic acid 0.1 Fragrance composition A 1.3 Methylparaben 0.18 Anhydrous sodium sulfate 1 Water balance Total 100 *1 Abrasive silica: Zeodent 124 manufactured by EVONIK Corporation *2 Thickening silica: "Carplex #67Q (liquid absorption capacity 2.3)" manufactured by DSL Japan Co., Ltd. *3 Sodium carboxymethylcellulose: "CMC1260" manufactured by Daicel Mirise Co., Ltd.

[0146] Formulation Example 31: Toothpaste Composition Pyridoxine hydrochloride 2.5 Polishable silica*1 8 Thickening silica*2 6 Titanium dioxide 0.6 Propylene glycol 4 Polyethylene glycol 4000 0.5 Sodium saccharin 0.18 Tocopherol acetate 0.1 Sodium fluoride 0.32 Potassium nitrate 5 Tranexamic acid 0.2 Allantoin 0.2 Isopropylmethylphenol 0.2 Sodium lauroyl methyl taurate 1.5 Polyoxyethylene (20) hydrogenated castor oil 0.25 Polyoxyethylene(5) stearyl ether 0.25 Coconut oil fatty acid amidopropyl betaine*3 0.3 70% sorbitol solution 45 Propylene glycol alginate 0.1 Sodium alginate 0.6 Xanthan gum 1.2 Citric acid 0.25 Sodium citrate 0.5 Phytosteryl isostearate 0.3 Isostearic acid 0.3 Fragrance composition A 1.3 Methylparaben 0.18 Water balance Total 100 *1 Abrasive silica: Zeodent 124 manufactured by EVONIK Corporation *2 Thickening silica: "Carplex #67Q (liquid absorption capacity 2.3)" manufactured by DSL Japan Co., Ltd. *3 Coconut oil fatty acid amidopropyl betaine solution: A 30% pure solution was used, and the amount of the solution used is indicated.

[0147] Formulation Example 32: Toothpaste Composition Pyridoxine hydrochloride 3 Polishable silica*1 10 Thickening silica*2 3 Propylene glycol 4 Polyethylene glycol 4000 0.4 Sodium saccharin 0.2 Tocopherol acetate 0.1 Sodium fluoride 0.32 Tranexamic acid 0.05 Potassium nitrate 5 Isopropylmethylphenol 0.05 Sodium polyphosphate 1 Sodium azulene sulfonate 0.01 Sodium lauroyl methyl taurate 0.2 Polyoxyethylene (5) hydrogenated castor oil 1.5 Coconut oil fatty acid amidopropyl betaine*3 0.6 70% sorbitol solution 20 85% Glycerin 20 Propylene glycol alginate 0.1 Xanthan gum 1.6 Sodium alginate 0.6 Titanium mica 0.7 Red No. 106 0.000025 Yellow No. 4 0.00025 Fragrance composition A 1 Water balance Total 100 *1 Abrasive silica: Zeodent 124 manufactured by EVONIK Corporation *2 Thickening silica: "Carplex #67Q (liquid absorption capacity 2.3)" manufactured by DSL Japan Co., Ltd. *3 Coconut oil fatty acid amidopropyl betaine solution: A 30% pure solution was used, and the amount of the solution used is indicated.

[0148] Formulation Example 33: Toothpaste Composition Pyridoxine hydrochloride 1 Polishable silica*1 10 Thickening silica*2 1 Aluminum oxide 0.1 Propylene glycol 4 Polyethylene glycol 400 1 Polyethylene glycol 4000 0.4 Sodium saccharin 0.15 Xylitol 2 Sucralose 0.003 Tocopherol acetate 0.1 Sodium monofluorophosphate 1.1 Phellodendron bark extract 0.05 Isopropylmethylphenol 0.1 Tranexamic acid 0.05 Sodium chloride 5 Hinokitiol 0.05 Sodium lauroyl sarcosinate 0.2 Sodium lauryl sulfate 1.5 Polyoxyethylene (5) hydrogenated castor oil 2.5 Coconut oil fatty acid amidopropyl betaine*3 0.1 70% sorbitol solution 45 Xanthan gum 0.3 Carrageenan 0.9 Sodium alginate 0.9 Aluminum potassium sulfate 1 Sodium hydroxide 0.1 Fragrance composition A 0.7 Water balance Total 100 *1 Thickening silica: "Carplex #67Q (liquid absorption capacity 2.3)" manufactured by DSL Japan Co., Ltd. *2 Thickening silica: "Aerosil 200 (liquid absorption capacity 4.2)" manufactured by Nippon Aerosil Co., Ltd. *3 Coconut oil fatty acid amidopropyl betaine solution: A 30% pure solution was used, and the amount of the solution used is indicated.

[0149] Formulation Example 34: Toothpaste Composition Pyridoxine hydrochloride 0.5 Polishable silica*2 10 Thickening silica*3 3 Titanium dioxide 0.5 Propylene glycol 1 Polyethylene glycol 4000 3 Sodium saccharin 0.2 Tocopherol acetate 0.1 Sodium fluoride 0.32 Dextranase*1 0.2 (Enzyme activity per gram of preparation: 20 U) Sodium tripolyphosphate 2 Benzalkonium chloride 0.01 Sodium lauryl sulfate 0.3 N-lauroyl-L-sodium glutamate 1 Polyoxyethylene (20) hydrogenated castor oil 1 Polyoxyethylene (5) stearyl ether 1 Decaglycerin fatty acid ester 0.1 Coconut oil fatty acid amidopropyl betaine solution*4 2 70% sorbitol solution 35 Xanthan gum 0.5 Sodium polyacrylate 0.5 Carrageenan 0.3 DL-Alanine 0.2 Fragrance composition A 1.2 Water balance Total 100 *1 Dextranase: Dextranase 2F (enzyme activity 4000 U / g) manufactured by Mitsubishi Chemical Corporation. *2 Abrasive silica: Zeodent 124 manufactured by EVONIK Corporation *3 Thickening silica: "Carplex #67Q (liquid absorption capacity 2.3)" manufactured by DSL Japan Co., Ltd. *4 Coconut oil fatty acid amidopropyl betaine solution: A 30% pure solution was used, and the amount of the solution used is indicated.

[0150] Formulation Example 35: Toothpaste Composition Pyridoxine hydrochloride 0.5 Polishable silica*1 14.5 Propylene glycol 3 Sodium saccharin 0.15 Sucralose 0.01 Sodium fluoride 0.32 Sodium lauryl sulfate 1.2 N-lauroyl-L-glutamate sodium 0.3 70% sorbitol solution 35 Sodium alginate 1 Fragrance composition A 1.3 Water balance Total 100 *1 Abrasive silica: Zeodent 124 manufactured by EVONIK Corporation *2 Thickening silica: "Carplex #67Q (liquid absorption capacity 2.3)" manufactured by DSL Japan Co., Ltd.

[0151] Formulation Example 36: Toothpaste Composition Pyridoxine hydrochloride 0.5 Heavy calcium carbonate 4 Granular zeolite (average particle size 282 μm)*1 4 Thickening silica*2 4 Aluminum Oxide 2 Propylene glycol 2 Sodium saccharin 0.17 Sodium fluoride 0.32 Sodium lauryl sulfate 1 Polyoxyethylene (20) hydrogenated castor oil 0.5 70% sorbitol solution 30 Sodium carboxymethylcellulose*3 1.5 Methylparaben 0.2 Fragrance composition A 1 Water balance Total 100 *1 Granular zeolite: Zeolite; 80%, Anhydrous silicic acid; 18.89%, Titanium dioxide; 0.1%, Blue No. 201; 0.01% *2 Thickening silica: "Carplex #67Q (liquid absorption capacity 2.3)" manufactured by DSL Japan Co., Ltd. *3 Sodium carboxymethylcellulose: "CMC1260" manufactured by Daicel Mirise Co., Ltd.

[0152] Formulation Example 37: Toothpaste Composition Pyridoxine hydrochloride 0.5 Polishable silica*1 8 Silica granules (average particle size 250 μm) *2 3 Silica granules (average particle size 100 μm) * 3 3 Propylene glycol 3 Sodium saccharin 0.1 Sodium fluoride 0.32 Sodium lauryl sulfate 1.5 70% sorbitol solution 40 Sodium carboxymethylcellulose*4 1.5 Fragrance composition A 1 Water balance Total 100 *1 Abrasive silica: Zeodent 124 manufactured by EVONIK Corporation *2 Silica granules: SORBOSIL BFG50 *3 Silica granules: SORBOSIL BFG10 *4 Carboxymethylcellulose sodium: "CMC1260" manufactured by Daicel Mirise Co., Ltd.

[0153] Formulation Example 38: Toothpaste Composition Pyridoxine hydrochloride 0.5 Polishable silica*1 14.5 Propylene glycol 0.5 Sodium saccharin 0.2 Sucralose 0.001 Tocopherol acetate 0.2 Sodium fluoride 0.32 Dipotassium glycyrrhizinate 0.1 Isopropylmethylphenol 0.05 Cetylpyridinium chloride 0.05 Alkyl glucoside 1 Polyoxyethylene (10) cetyl ether 1 70% sorbitol solution 40 Sodium carboxymethylcellulose*3 1 Sodium polyacrylate 0.2 Propylene glycol alginate 0.1 Sodium pyrrolidonecarboxylate 3 Fragrance composition A 1.2 Water balance Total 100 *1 Abrasive silica: Zeodent 124 manufactured by EVONIK Corporation *2 Thickening silica: "Carplex #67Q (liquid absorption capacity 2.3)" manufactured by DSL Japan Co., Ltd. *3 Sodium carboxymethylcellulose: "CMC1260" manufactured by Daicel Mirise Co., Ltd.

[0154] Formulation Example 39: Toothpaste Composition Pyridoxine hydrochloride 0.5 Polishable silica*1 10 Thickening silica*2 3 Titanium dioxide 0.05 Propylene glycol 3 Polyethylene glycol 4000 0.2 Sodium saccharin 0.2 Tocopherol acetate 0.5 Stannous fluoride 0.6 Tranexamic acid 0.05 Isopropylmethylphenol 0.05 Sodium lauroyl methyl taurate 1 Sodium tetradecenesulfonate 0.5 Polyoxyethylene (5) hydrogenated castor oil 2 70% sorbitol solution 40 Xanthan gum 1.2 Sodium alginate 0.4 Propylene glycol alginate 0.1 Titanium mica 0.3 Citric acid 0.8 Sodium citrate 0.5 Fragrance composition A 1 Water balance Total 100 *1 Abrasive silica: Zeodent 124 manufactured by EVONIK Corporation *2 Thickening silica: "Carplex #67Q (liquid absorption capacity 2.3)" manufactured by DSL Japan Co., Ltd.

[0155] Formulation Example 40: Toothpaste Composition Pyridoxine hydrochloride 0.5 Polishable silica*1 10 Thickening silica*2 1 Titanium dioxide 0.05 Zinc oxide 0.3 Propylene glycol 3 Polyethylene glycol 4000 0.2 Sodium saccharin 0.2 Tocopherol acetate 0.5 Stannous fluoride 0.4 Sodium fluoride 0.11 Tranexamic acid 0.05 Isopropylmethylphenol 0.05 Sodium lauroyl methyl taurate 1 Sodium tetradecenesulfonate 0.5 Polyoxyethylene (5) hydrogenated castor oil 2 70% sorbitol solution 40 Xanthan gum 1.2 Sodium alginate 0.4 Propylene glycol alginate 0.1 Titanium mica 0.3 Citric acid 0.8 Sodium citrate 0.5 Fragrance composition A 1 Water balance Total 100 *1 Abrasive silica: Zeodent 124 manufactured by EVONIK Corporation *2 Thickening silica: "Carplex #67Q (liquid absorption capacity 2.3)" manufactured by DSL Japan Co., Ltd.

[0156] Formulation Example 41: Toothpaste Composition Pyridoxine hydrochloride 0.5 Polishable silica*1 10 Thickening silica*2 1 Titanium dioxide 0.05 Zirconium oxide 0.5 Propylene glycol 3 Polyethylene glycol 4000 0.2 Sodium saccharin 0.2 Tocopherol acetate 0.5 Stannous fluoride 0.4 Sodium monofluorophosphate 0.38 Tranexamic acid 0.05 Isopropylmethylphenol 0.05 Sodium lauroyl methyl taurate 1 Sodium tetradecenesulfonate 0.5 Polyoxyethylene (5) hydrogenated castor oil 2 70% sorbitol solution 40 Xanthan gum 1.2 Sodium alginate 0.4 Propylene glycol alginate 0.1 Titanium mica 0.3 Citric acid 0.8 Sodium citrate 0.5 Fragrance composition A 1 Water balance Total 100 *1 Abrasive silica: Zeodent 124 manufactured by EVONIK Corporation *2 Thickening silica: "Carplex #67Q (liquid absorption capacity 2.3)" manufactured by DSL Japan Co., Ltd.

[0157] Formulation Example 42: Toothpaste Composition Pyridoxine hydrochloride 0.5 Thickening silica*1 3 Propylene glycol 5 Tocopherol acetate 2 Sodium fluoride 0.32 Glycyrrhetinic acid 0.3 Cetylpyridinium chloride 0.05 Sodium lauryl sulfate 1.6 Sorbitan monostearate 1 POE(20) Sorbitan Monostearate 1.5 Sucrose fatty acid ester 2 Hydroxyethylcellulose*2 1.5 Hydroxypropyl methylcellulose*3 1 Carboxyvinyl polymer 2.1 Polyvinylpyrrolidone 1 70% sorbitol solution 20 Ethanol 1 Light liquid paraffin 2 Cetanol 1.4 Fragrance composition A 1.5 Water balance Total 100 *1 Thickening silica: "Aerosil 200 (liquid absorption capacity 4.2)" manufactured by Nippon Aerosil Co., Ltd. *2 Hydroxyethylcellulose: "HEC Daicel EE-820" manufactured by Daicel Mirise Co., Ltd. *3 Hydroxypropyl methylcellulose: "METOLOSE Hypromellose 90SH-4000SR" manufactured by Shin-Etsu Chemical Co., Ltd.

[0158] Formulation Example 43: Toothpaste Composition Pyridoxine hydrochloride 1 Thickening silica*1 3 Propylene glycol 7 Tocopherol acetate 1.5 Sodium fluoride 0.32 Dipotassium glycyrrhizinate 0.4 Cetylpyridinium chloride 0.05 Hinokitiol 0.1 Allantoin 0.3 Sodium lauryl sulfate 1.1 Sorbitan monostearate 0.1 POE(20) Sorbitan Monostearate 0.15 Sucrose fatty acid ester 0.5 Hydroxypropyl methylcellulose*2 0.3 Carboxyvinyl polymer*3 2.1 Polyvinylpyrrolidone*4 1 Sodium alginate*5 0.3 70% sorbitol solution 25 Ethanol 3 Light liquid paraffin 0.5 Fragrance composition A 1 Water balance Total 100 *1 Thickening silica: "Aerosil 200 (liquid absorption capacity 4.2)" manufactured by Nippon Aerosil Co., Ltd. *2 Hydroxypropyl methylcellulose: "METOLOSE Hypromellose 90SH-4000SR" manufactured by Shin-Etsu Chemical Co., Ltd. *3 Carboxyvinyl polymer: Lublizol's "Carbopol980NF" *4 Polyvinylpyrrolidone: "PLASDONE K-90" manufactured by ISP Corporation *5 Sodium alginate: "Kimika Algin ULV-20" manufactured by Kimika Co., Ltd.

[0159] Furthermore, when oral compositions with the same composition as those in Examples 1-36 and Formulation Examples 1-43 were prepared and evaluated, except that fragrance compositions B-S were used instead of fragrance composition A, the evaluation results remained unchanged.

Claims

1. (A) Components: Pyridoxine or a salt thereof, (B) Component: Contains inorganic powder, (A) The content of component is 0.01% by mass to 3% by mass, (B) An oral composition having a content of 0.01% by mass or more and less than 15% by mass of component.

2. The oral composition according to claim 1, wherein component (B) is one or more selected from the group consisting of thickening anhydrous silicic acid, abrasive anhydrous silicic acid, heavy calcium carbonate, anhydrous calcium hydrogen phosphate, titanium dioxide, aluminum oxide, and zinc oxide.

3. (C) Component: The oral composition according to claim 1 or 2, further comprising one or more selected from the group consisting of polyethylene glycol and propylene glycol.

4. The oral composition according to claim 3, wherein the content of component (C) is 0.05% to 10% by mass.

5. (D) The oral composition according to claim 1 or 2, further comprising one or more selected from the group consisting of sodium saccharin, sucralose, xylitol, erythritol, maltitol, acesulfame potassium, trehalose, and mannitol.

6. The oral composition according to claim 5, wherein the content of component (D) is 0.01% to 10% by mass.

7. (E) Component: The oral composition according to claim 1 or 2, further comprising one or more selected from the group consisting of tocopherol acetate and tocopherol nicotinate.

8. The oral composition according to claim 7, wherein the content of component (E) is 0.03% to 2% by mass.

9. The oral composition according to claim 1 or 2, wherein the ratio of the content of component (A) to the content of component (B) ((A) / (B)) is 0.0003 to 20.

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