Aerosol-Generating Materials

Abstract

Described herein are aerosol-generating materials, including botanical material, that when heated generate an aerosol having a flavor dilution factor of less than about 10,000, aerosol-generating materials for use in delivery systems, five processes for generating an aerosol, and uses of the aerosol-generating materials.

Description

[Technical Field]

[0001] The present disclosure relates to an aerosol-forming material including a fibrous material, and a non-combustion aerosol delivery system including the aerosol-forming material. [Background technology]

[0002] The aerosol-forming material is typically heated, for example, by a non-combustion aerosol delivery system, to form an aerosol that can be inhaled by a consumer. The aerosol-forming material may be made from a variety of different sources, including tobacco and / or non-tobacco materials. According to a first aspect, an aerosol-forming material is described that includes plant material, and that, when heated, produces an aerosol that includes a flavor dilution factor of less than about 10,000. Summary of the Invention

[0003] According to a first aspect, an aerosol-forming material is described that includes a botanical material, the aerosol-forming material generating an aerosol that, when heated, includes a flavor dilution factor of less than about 10,000.

[0004] According to a second aspect, an aerosol-generating material is described, comprising a plant material that generates an aerosol when heated, the aerosol comprising vanillin, dimethyl trisulfide, and 2,3-butanedione.

[0005] According to a third aspect, there is described an aerosol-generating material comprising a plant material that generates an aerosol when heated, the aerosol comprising vanillin, dimethyl trisulfide, and furaneol.

[0006] According to a fourth aspect, there is described an aerosol-generating material comprising a fibrous material capable of releasing volatile compounds when heated, the volatile compounds comprising vanillin, dimethyl trisulfide, and 2,3-butanedione.

[0007] According to a fifth aspect, an aerosol is described comprising at least one active substance, an organic acid, and at least one of vanillin, dimethyl trisulfide, and 2,3-butanedione, wherein the aerosol is generated by aerosolization of an aerosol-generating material comprising botanical material, the active substance, the organic acid, and an aerosol-forming agent.

[0008] According to a sixth aspect, there is described an aerosol-generating material for use in a delivery system, the aerosol-generating material comprising a botanical material, at least one nicotine salt, and an aerosol former, wherein the aerosol-generating material generates an aerosol comprising vanillin, dimethyl trisulfide, and 2,3-butanedione.

[0009] According to a seventh aspect, a delivery system is described that includes an aerosol-generating material configured to generate an aerosol comprising an active substance and at least two of vanillin, dimethyl trisulfide, and 2,3-butanedione, wherein the at least two of vanillin, dimethyl sulfide, and 2,3-butanedione constitute at least 35% of the aerosol.

[0010] According to an eighth aspect, a method of generating an inhalable aerosol comprising an active substance and at least two of vanillin, dimethyl trisulfide, and 2,3-butanedione is described, the method comprising heating a material comprising a plant material, a nicotine source, and an aerosol-forming agent.

[0011] According to a ninth aspect, there is described the use of an aerosol-forming material comprising plant material to generate an aerosol comprising vanillin, dimethyl trisulfide and 2,3-butanedione.

[0012] Embodiments of the present invention will now be described, by way of example only, with reference to the accompanying drawings, in which: [Brief explanation of the drawings]

[0013] [Figure 1] FIG. 1 shows a flowchart of a method of making an aerosol-forming material. DETAILED DESCRIPTION OF THE INVENTION

[0014] The present invention relates to aerosol-generating materials. The present invention also relates to aerosols, methods of making the aerosol-generating materials, uses of the aerosol-generating materials, articles for use in delivery systems, and systems comprising the aerosol-generating materials and devices.

[0015] The aerosol-generating material includes an aerosolizable component. During use, the aerosol-generating material generates an aerosol, e.g., a suspension of droplets or fine particles in a gas. The aerosol includes nicotine and other components generated by the aerosol-generating material. During use, the user inhales the aerosol. Therefore, it is important that the aerosol-generating material generate an aerosol that provides a suitable user experience and satisfaction.

[0016] The composition of the aerosol contributes to the user's experience and satisfaction. One attribute that contributes to the user's experience and satisfaction is the nicotine content in the aerosol. Another attribute that contributes to the user's experience and satisfaction is the perceived harshness of the aerosol. Therefore, it is important to control the nicotine content and harshness of the aerosol.

[0017] In some examples, aerosol-forming materials containing nicotine and an organic acid have been found to produce aerosols with a perceived harshness that is desirable. The inventors have noted that aerosol-forming materials containing pure nicotine, e.g., free-base nicotine, produce aerosols with a perceived harshness that may be too high for some consumers. The addition of an organic acid reduced the perceived harshness to a desirable level. Alternatively, aerosol-forming materials containing nicotine salts may produce aerosols with a perceived harshness that is desirable.

[0018] As used herein, the term "delivery system" is intended to encompass a system that delivers a substance to a user; Combustion aerosol delivery systems, such as cigarettes, cigarillos, cigars, and tobacco for pipes or for hand-rolled or handmade cigarettes (whether based on tobacco, tobacco derivatives, expanded tobacco, reconstituted tobacco, tobacco substitutes, or other smokable materials); Non-combustion aerosol delivery systems that release compounds from aerosol-forming materials without burning the aerosol-forming material, such as electronic cigarettes, tobacco heating products, and hybrid systems that generate aerosols using a combination of aerosol-forming materials; and Aerosol-free delivery systems, such as lozenges, gums, patches, articles containing inhalable powders, and smokeless tobacco products such as snus and snuff, that deliver materials to the user without forming an aerosol Includes:

[0019] According to the present disclosure, a "combustion-based" aerosol delivery system is one in which the constituent aerosol-generating materials (or components thereof) of the aerosol delivery system are combusted or burned during use to facilitate delivery of at least one substance to a user.

[0020] In some embodiments, the delivery system is a combustion aerosol delivery system, such as a system selected from the group consisting of a cigarette, a cigarillo, and a cigar.

[0021] According to the present disclosure, a "non-combustion" aerosol delivery system is one in which the constituent aerosol-generating materials (or components thereof) of the aerosol delivery system are not or are not combusted to facilitate delivery to a user.

[0022] In some embodiments, the delivery system is a non-combustion aerosol delivery system, such as a powered non-combustion aerosol delivery system.

[0023] In some embodiments, the non-combustion aerosol delivery system is a vaporization device or an electronic cigarette, also known as an electronic nicotine delivery system (END).

[0024] In some embodiments, the non-combustion aerosol delivery system is a tobacco heating system, also known as a non-combustion heating system.

[0025] In some embodiments, the non-combustion aerosol delivery system is a hybrid system that generates an aerosol using a combination of aerosol-forming materials, where one or more aerosol-forming materials can be heated. Each of the aerosol-forming materials can be, for example, in the form of a solid, liquid, or gel. In some embodiments, the hybrid system includes a liquid or gel aerosol-forming material and a solid aerosol-forming material. The solid aerosol-forming material can include, for example, a tobacco material or a non-tobacco product.

[0026] Typically, a non-combustion aerosol delivery system may include a non-combustion aerosol delivery device, also referred to herein as an aerosol generating device, and consumables for use with the non-combustion aerosol delivery system.

[0027] In some embodiments, the present disclosure relates to consumables that include aerosol-generating materials and are configured for use with non-combustion aerosol delivery devices. These consumables may be referred to as articles throughout this disclosure.

[0028] It is envisioned that in some embodiments, a consumable that itself includes a means for powering an aerosol generating component may itself form a non-combustion aerosol delivery system.

[0029] In some embodiments, the non-combustion aerosol delivery system may include a power source and a controller. The power source may be a power source or a heat-generating power source. In some embodiments, the heat-generating power source comprises a carbon substrate that can be energized to deliver power in the form of heat to an aerosol-generating material or a heat transfer material proximate the heat-generating power source. In some embodiments, the power source, such as the heat-generating power source, is provided with an article to form the non-combustion aerosol delivery system.

[0030] In some embodiments, the non-combustion aerosol delivery system may include an area for receiving a consumable, an aerosol generator, an aerosol-generating area, a housing, a mouthpiece, a filter, and / or an aerosol modifier.

[0031] In some embodiments, a consumable for use with a non-combustion aerosol delivery device may comprise an aerosol-generating material, an aerosol-generating material storage region, an aerosol-generating material transfer component, an aerosol generator, an aerosol-generating region, a housing, a packaging material, a filter, a mouthpiece, and / or an aerosol modifier.

[0032] In some embodiments, the substance to be delivered includes an active substance. As used herein, an active substance may be a physiologically active material, which is a material intended to achieve or enhance a physiological response. The active substance may be selected from, for example, a dietary supplement, a nootropic, or a psychoactive agent. The active substance may be naturally occurring or synthetically obtained. The active substance may include, for example, nicotine, caffeine, taurine, theine, vitamins such as B6, B12, or C, melatonin, cannabinoids, or components, derivatives, or combinations thereof. The active substance may include one or more components, derivatives, or extracts of tobacco, cannabis, or another botanical material.

[0033] In some embodiments, the active substance is a legally permitted recreational drug.

[0034] In some embodiments, the active agent comprises nicotine, hi some embodiments, the active agent comprises caffeine, melatonin, or vitamin B12.

[0035] As described herein, the active substance may include one or more components, derivatives, or extracts of cannabis, such as one or more cannabinoids or terpenes.

[0036] In some embodiments, the aerosol-generating material comprises a cannabinoid selected from the list consisting of cannabigerol (CBG), cannabichromene (CBC), cannabidiol (CBD), tetrahydrocannabinol (THC), cannabinol (CBN), cannabinodiol (CBDL), cannabicyclol (CBL), cannabivarin (CBV), tetrahydrocannabivarin (THCV), cannabidivarin (CBDV), cannabichromevarin (CBCV), cannabigerovarin (CBGV), cannabigerol monomethyl ether (CBGM), cannabinerolic acid, cannabidiolic acid (CBDA), cannabinol propyl variant (CBNV), cannbitriol (CBO), tetrahydrocannabinolic acid (THCA), and tetrahydrocannabivarinic acid (THCV A), and mixtures thereof.

[0037] In some embodiments, the aerosol-forming material comprises CBD or a derivative thereof.

[0038] As used herein, the term "botanical material" includes any material derived from a plant, including, but not limited to, extracts, leaves, bark, fiber, stems, roots, seeds, flowers, fruit, pollen, husks, shells, etc. Alternatively, the material may include synthetically derived active compounds that are naturally present in the botanical material. The material may be in the form of a liquid, gas, solid, powder, dust, ground particles, granules, pellets, chips, strips, sheets, etc. Exemplary botanicals include tobacco, eucalyptus, star anise, hemp, cocoa, cannabis, fennel, lemongrass, peppermint, spearmint, rooibos, chamomile, flax, ginger, ginkgo, hazel, hibiscus, bay, licorice, matcha, yerba mate, orange peel, papaya, rose, sage, tea such as green tea or black tea, thyme, cloves, cinnamon, coffee, aniseed, basil, bay leaf, cardamom, coriander, cumin, nutmeg, oregano, paprika, rosemary, saffron, rabe The preferred oleic acid extracts are laurel, lemon peel, mint, juniper, elderflower, vanilla, wintergreen, shiso, curcuma, turmeric, sandalwood, cilantro, bergamot, orange blossom, myrtle, blackcurrant, valerian, pimento, mace, damiana, marjoram, olive, lemon balm, lemon basil, chives, kahlua, verbena, tarragon, geranium, mulberry, ginseng, theanine, theacrine, maca, ashwagandha, damiana, guarana, chlorophyll, baobab, or any combination thereof.The mint may be selected from the following mint varieties: Mentha arventis, Mentha cv, Egyptian mint (Mentha niliaca), Mentha piperita, Cologne mint (Mentha piperita citrata cv), Candy mint (Mentha piperita cv), Curly mint (Mentha spicata crispa), Kentucky Colonel mint (Mentha cardifolia), Horse mint (Mentha longifolia), Pineapple mint (Mentha suaveolens variegata), Pennyroyal mint (Mentha pulegium), Green mint (Mentha spicata cv), and Apple mint (Mentha suaveolens).

[0039] In some embodiments, the active agent comprises or is derived from one or more botanical substances, or components, derivatives, or extracts thereof, and the botanical substances are selected from eucalyptus, cocoa, and hemp.

[0040] In some embodiments, the active agent comprises or is derived from one or more botanical substances, or components, derivatives, or extracts thereof, and the botanical substances are selected from star anise, rooibos, mint, and fennel.

[0041] In some embodiments, the substance to be delivered comprises a flavor.

[0042] As used herein, the terms "flavor" and "flavoring agent" refer to materials that may be used, where local regulations permit, to create a desired taste, aroma, or other somatic sensation in products intended for adult consumers.Flavors and flavorings include naturally occurring flavoring materials, botanicals, extracts of botanicals, synthetically derived materials, or combinations thereof (e.g., tobacco, cannabis, licorice, hydrangea, eugenol, magnolia leaf, chamomile, fenugreek, clove, maple, matcha, menthol, Japanese mint, aniseed, cinnamon, turmeric, Indian spices, Asian spices, herbs, wintergreen, cherry, berry, red berry, cranberry, peach, apple, orange, mango, clementine, lemon, rye, etc.). Musk, tropical fruits, papaya, rhubarb, grapes, durian, dragon fruit, cucumber, blueberry, mulberry, citrus fruits, Drambuie, bourbon, scotch, whiskey, gin, tequila, rum, spearmint, peppermint, lavender, aloe vera, cardamom, celery, cascarilla, nutmeg, sandalwood, bergamot, geranium, khat, eggplant, betel nut, shisha, pine, honey essence, rose oil, vanilla, lemon oil, orange oil, orange blossom, cherry blossom, cassia, caraway, cognac, jasmine, ylang ylang , sage, fennel, wasabi, bell pepper, ginger, coriander, coffee, hemp, peppermint oil from any species of the genus Mentha, eucalyptus, star anise, cocoa, lemongrass, rooibos, flax, ginkgo, hazel, hibiscus, bay leaf, yerba mate, orange peel, rose, tea such as green or black tea, thyme, juniper, elderflower, basil, bay leaf, cumin, oregano, paprika, rosemary, saffron, lemon peel, mint, shiso, curcuma, cilantro, myrtle, black currant, valerian, pimento, mace, damiento, maji The flavor enhancers may include other additives such as cholams, olives, lemon balm, lemon basil, chives, Calvi, verbena, tarragon, limonene, thymol, camphene), flavor enhancers, bitter taste receptor site blockers, sensory receptor site activators or stimulants, sugars and / or sugar substitutes (e.g., sucralose, acesulfame potassium, aspartame, saccharin, cyclamate, lactose, sucrose, glucose, fructose, sorbitol, or mannitol), and charcoal, chlorophyll, minerals, botanicals, or breath fresheners.The flavors and flavorings may be imitation, synthetic, or natural ingredients, or blends thereof. The flavors and flavorings may be in any suitable form, for example, a liquid such as an oil, a solid such as a powder, or a gas.

[0043] In some embodiments, the flavor comprises menthol, spearmint, and / or peppermint. In some embodiments, the flavor comprises cucumber, blueberry, citrus, and / or red berry flavor components. In some embodiments, the flavor comprises eugenol. In some embodiments, the flavor comprises flavor components extracted from tobacco. In some embodiments, the flavor comprises flavor components extracted from cannabis, such as terpenes.

[0044] In some embodiments, the aerosol-forming material comprises menthol.

[0045] In some embodiments, the flavor may include a sensation elicitor intended to achieve somatic sensations typically chemically induced and perceived by stimulation of the fifth cranial nerve (trigeminal nerve) in addition to, or instead of, aroma or taste nerves, and may include agents that produce heating, cooling, tingling, or numbing effects. Suitable heating agents may be, but are not limited to, vanillyl ethyl ether, and suitable cooling agents may be, but are not limited to, eucolyptol, WS-3.

[0046] The flavoring agent is preferably present in any amount to deliver the desired flavor to the aerosol. The amount of flavoring agent may be defined relative to the total weight of the aerosol. The flavoring agent may be food-grade, which would be understood by those skilled in the art as a material that is non-toxic and safe for human consumption.

[0047] An aerosol-forming material is a material that can generate an aerosol when, for example, heated, irradiated, or otherwise energized. The aerosol-forming material may be in solid, liquid, or semi-solid (such as a gel) form, for example, which may or may not contain active substances and / or flavorings.

[0048] The aerosol-forming materials may include one or more active agents and / or flavors, one or more aerosol former materials, and optionally one or more other functional materials.

[0049] In some embodiments, the aerosol-forming material includes rooibos.

[0050] The aerosol-generating material may comprise or be a continuous sheet of material. The sheet may be in the form of a wrapper, gathered to form a gathered sheet, or chopped to form a chopped sheet. The chopped sheet may comprise one or more strands or strips of aerosol-generating material.

[0051] The sheet or shredded sheet includes a first surface and a second surface opposite the first surface. The first and second surfaces have matching dimensions. The first and second surfaces of the sheet or shredded sheet may have any shape. For example, the first and second surfaces may be square, rectangular, oval, or circular. Irregular shapes are also contemplated.

[0052] The first and / or second surfaces of the sheet or shredded sheet may be relatively uniform (e.g., relatively smooth), or may be uneven or irregular. For example, the first and / or second surfaces of the sheet may be textured or patterned to define a relatively rough surface. In some embodiments, the first and / or second surfaces are relatively rough.

[0053] The smoothness of the first and second surfaces may be affected by many factors, such as the areal density of the sheet or shredded sheet, the nature of the components that make up the aerosolizable material, or whether the surface of the material has been manipulated, for example, embossed, scored, or otherwise modified to impart a pattern or texture.

[0054] The areas of the first and second surfaces are defined by a first dimension (e.g., width) and a second dimension (e.g., length), respectively. The first and second dimensional measurements may have a ratio of 1:1 or greater than 1:1, and thus the sheet or shredded sheet may have an "aspect ratio" of 1:1 or greater than 1:1. As used herein, the term "aspect ratio" is the ratio of the first dimensional measurement of the first or second surface to the second dimensional measurement of the first or second surface. A "1:1 aspect ratio" means that the first dimensional measurement (e.g., width) and the second dimensional measurement (e.g., length) are identical. An "aspect ratio greater than 1:1" means that the first dimensional measurement (e.g., width) and the second dimensional measurement (e.g., length) are different. In some embodiments, the first and second surfaces of the sheet or shredded sheet have an aspect ratio of greater than 1:1, such as 1:2, 1:3, 1:4, 1:5, 1:6, 1:7, or more.

[0055] The shredded sheet may comprise one or more strands or strips of aerosolizable material. In some embodiments, the shredded sheet comprises multiple (e.g., two or more) strands or strips of aerosolizable material. The strands or strips of aerosolizable material may have an aspect ratio of 1:1. In one embodiment, the strands or strips of aerosolizable material have an aspect ratio of greater than 1:1. In some embodiments, the strands or strips of aerosolizable material have an aspect ratio of about 1:5 to about 1:16, or about 1:5, 1:6, 1:7, 1:8, 1:9, 1:10, 1:11, or 1:12. When the aspect ratio of the strands or strips is greater than 1:1, the strands or strips comprise a longitudinal dimension or length extending between a first end of the strand or strip and a second end of the strand or strip.

[0056] When a shredded sheet includes multiple strands or strips of material, the dimensions of each strand or strip may vary among different strands or strips. For example, a shredded sheet may include a first collection of strands or strips and a second collection of strands or strips, where the dimensions of the strands or strips in the first collection are different from the dimensions of the strands or strips in the second collection. In other words, the multiple strands or strips may include a first collection of strands or strips having a first aspect ratio and a second collection of strands or strips having a second aspect ratio that is different from the first aspect ratio.

[0057] The first dimension or cut width of the strand or strip of aerosolizable material is between 0.9 mm and 1.5 mm. The inventors have found that when strands or strips of aerosolizable material having a cut width of less than 0.9 mm are incorporated into an article for use in a non-combustion aerosol delivery system, the pressure drop across the article may be increased to a level that makes the article unsuitable for use in a non-combustion aerosol delivery device. However, if the strand or strip has a cut width greater than 2 mm (e.g., greater than 2 mm), it may be difficult to insert the strand or strip of aerosolizable material into the article during manufacture of the article. In a preferred embodiment, the cut width of the strand or strip of aerosolizable material is between about 1 mm and 1.5 mm.

[0058] The strands or strips of material are formed by shredding a sheet of aerosolizable material. The sheet of aerosolizable material may be cut widthwise, for example, by a cross-cut shredding method, to define a cut length of the strands or strips of aerosolizable material in addition to the cut width. The cut length of the shredded aerosolizable material is preferably at least 5 mm, e.g., at least 10 mm, or at least 20 mm. The cut length of the shredded aerosolizable material may be less than 60 mm, less than 50 mm, or less than 40 mm.

[0059] In some embodiments, multiple strands or strips of aerosolizable material are provided, wherein at least one of the multiple strands or strips of aerosolizable material has a length greater than about 10 mm. At least one of the multiple strands or strips of aerosolizable material may alternatively or additionally have a length of about 10 mm to about 60 mm, or about 20 mm to about 50 mm. Each of the multiple strands or strips of aerosolizable material may have a length of about 10 mm to about 60 mm, or about 20 mm to about 50 mm.

[0060] A consumable is an article containing or consisting of an aerosol-generating material, some or all of which is intended to be consumed during use by a user. In some embodiments, a consumable for use with a non-combustion aerosol delivery device may include one or more other components, such as an aerosol-generating material storage area, an aerosol-generating material transfer component, an aerosol generator, an aerosol-generating area, a housing, a packaging material, a filter, a mouthpiece, and / or an aerosol modifier. The consumable may also include an aerosol generator, such as a heater, that generates heat upon use to cause the aerosol-generating material to generate an aerosol. The heater may include, for example, a combustible material, a material heatable by electrical conduction, or a susceptor.

[0061] An aerosol generator is a heater that can interact with an aerosol-generating material to release one or more volatile substances from the aerosol-generating material to form an aerosol. In some embodiments, the aerosol generator can generate an aerosol from the aerosol-generating material without applying heat. For example, the aerosol generator can be capable of generating an aerosol from the aerosol-generating material without applying heat to the aerosol-generating material, such as by one or more of vibrational, mechanical, pressurized, or electrostatic means.

[0062] As discussed herein, the present invention provides methods for producing an inhalable medium, the methods comprising aerosolizing an aerosolizable formulation, such as an aerosol-forming material, as defined herein. In some embodiments, the aerosol is formed by a method carried out at a temperature of about 100°C to about 250°C.

[0063] In some embodiments, the aerosol-generating material may include one or more active substances. As used herein, an active substance may be a physiologically active material, which is a material intended to achieve or enhance a physiological response. The active substance may be selected from, for example, dietary supplements, nootropics, and psychoactive substances. The active substance may be naturally occurring or synthetically obtained. The active substance may include, for example, nicotine, caffeine, taurine, theine, vitamins such as B6, B12, or C, melatonin, cannabinoids, or components, derivatives, or combinations thereof. The active substance may include one or more components, derivatives, or extracts of tobacco, cannabis, or another botanical material.

[0064] In some embodiments, the aerosol-forming material comprises a non-nicotine active.

[0065] An aerosol is a suspension of liquid, solid, or both particles in a gas.

[0066] In one embodiment, the aerosol-forming material, when heated, produces an aerosol having a flavor dilution factor of less than about 10,000. For example, the aerosol may have a flavor dilution factor of less than about 9,000, such as less than about 8,000, such as less than about 7,000, or even less than about 6,500. In some embodiments, the aerosol has a flavor dilution factor of about 6,000 to about 6,500. The flavor dilution factor provides an indication of the number of aroma compounds in the aerosol and can be measured using gas chromatography and mass spectrometry. In particular, the flavor dilution factor represents the maximum dilution at which the compounds can still be perceived. For example, volatile compounds derived from the aerosol-forming material can be separated and subsequently monitored with a mass spectrometer. A single extract can be analyzed at different dilutions to assess the impact and intensity of each aroma within the sample. Samples with particularly high flavor dilution factors (FD factors) may be perceived as having a stronger aroma profile. An FD factor greater than about 10,000 provides a significant aroma perception to consumers. Certain consumers may dislike such high FD coefficients because the scent may be described as too strong or overpowering. Aerosols with FD coefficients greater than 10,000 may be difficult to match with additional top flavors because the scent may be too strong to perceive the additional flavor. Aerosols with FD coefficients less than about 10,000 provide consumers with a scent of preferred intensity and can be easily matched with flavors to enhance and / or modify the overall scent profile.

[0067] To identify aroma compounds, also called aroma-active compounds, an aroma extract dilution analysis (AEDA) may be performed. AEDA may be used to classify compounds according to their impact.

[0068] Aroma extract dilution analysis (AEDA) can be divided into several steps: sample preparation, aroma extract dilution analysis, high-resolution gas chromatography / olfactometry, and retention index determination. Sample preparation Sample preparation involves generating an aerosol from an aerosol-generating material, for example, the aerosol can be captured on a solid-phase extraction cartridge and subsequently eluted using a suitable solvent to provide an aroma extract.

[0069] AEDA The aroma extract may be diluted in 1:1 steps with the solvent.

[0070] High-resolution gas chromatography / olfactometry High-resolution gas chromatography is performed, for example, using trace GC.

[0071] Determination of retention index Homologous series n-alkanes (C6-C 26 ) and aroma compounds, the retention index was determined by linear interpolation according to the following equation:

number

[0072] In one embodiment, the aerosol-forming material generates an aerosol when heated, and the aerosol comprises vanillin, dimethyl trisulfide, and 2,3-butanedione. The vanillin and 2,3-butanedione may be described as having a creamy taste. The dimethyl trisulfide may be described as having a pungent taste. The inventors have found that when these compounds are combined in an aerosol, the perceived flavor is particularly pleasant.

[0073] In some embodiments, at least 50% of the total aerosol comprises vanillin, dimethyl trisulfide, and 2,3-butanedione, e.g., about 50% to about 70% of the total aerosol comprises vanillin, dimethyl trisulfide, and 2,3-butanedione.

[0074] In some embodiments, an aerosol comprising vanillin, dimethyl trisulfide, and 2,3-butanedione is formed from an aerosol-forming material that includes rooibos.

[0075] In one embodiment, the aerosol-forming material generates an aerosol when heated, and the aerosol includes vanillin, dimethyl trisulfide, and furaneol. Furaneol may be described as sweet in flavor. The aerosol including vanillin, dimethyl trisulfide, and furaneol may be particularly preferred by consumers for providing a pleasant aroma. The aerosol including vanillin, dimethyl trisulfide, and furaneol may be formed from an aerosol-forming material that includes star anise.

[0076] In one embodiment, the aerosol comprises an active agent and at least two of vanillin, dimethyl trisulfide, and 2,3-butanedione, and at least 35% of the total aerosol comprises at least two of vanillin, dimethyl trisulfide, and 2,3-butanedione.

[0077] In some embodiments, the fiber material includes a plant material. A fiber material including a plant material may complement the flavor profile of any aerosol generated. For example, a plant material having a relatively neutral flavor profile may be selected. A neutral flavor profile may be described as a flavor profile that contains few strong flavors and / or a flavor profile that easily accommodates a top flavor load without affecting the perception of the top flavor. For example, a fiber material containing reconstituted tobacco material may be described as producing an aerosol with a relatively neutral flavor profile. It may be advantageous to be able to produce an aerosol with a neutral flavor profile similar to reconstituted tobacco, but without using tobacco material.

[0078] In some embodiments, the fibrous material may be referred to as a substrate. It may be preferable for the substrate to be made from a non-tobacco material so that consumers may reduce their use of tobacco-based materials. However, consumers may wish to retain the physiological effects provided by nicotine. Therefore, it may be of interest to consumers to provide a substrate made from a non-tobacco plant material that includes nicotine.

[0079] As described herein, when discussing the amount of any one or more components in an aerosol, it can be understood to refer either to the amount by weight of the total aerosol, or alternatively, to the total volume of the aerosol.

[0080] In some embodiments, the plant material may be any non-tobacco plant material. For example, the material may be derived from a species that is a member of the Asteracae family, the Fabaceae family, the Myrtaceae family, the Apiaceae family, Camellia taliensis, the Solanaceae family, the Brassicaceae family, the Caricaceae family, the Asclepiadaceae family, the Equisetaceae family, the Oleaceae family, the Lamiaceae family, and the tisanes. For example, the non-tobacco plant material may be selected from Matricaria species such as chamomile, Pimpinella anisum species such as anise, Foeniculum vulgare species such as fennel, Aspalathus linearis species such as jasmine, lavender, clove, eucalyptus, and rooibos.

[0081] In some embodiments, the non-tobacco plant material is selected from plant materials containing desirable aroma characteristics for use in non-combustion aerosol delivery systems. For example, the non-tobacco plant material may contain relatively few aroma compounds compared to traditional tobacco materials. Thus, the aerosol generated from the non-tobacco plant material may have a different profile of volatile compounds compared to the aerosol generated from tobacco materials. The non-tobacco plant material may deliver an aerosol that is considered desirable by consumers of tobacco-based delivery systems. In some embodiments, the non-tobacco plant material, when heated, may produce an aerosol with a sensory experience comparable to that provided by traditional combustion products, such as cigarettes. In some embodiments, the non-tobacco plant material is selected from seed-producing plants that do not develop persistent woody tissue and are often valued for their medicinal or sensory properties. In some embodiments, it may be preferable to provide an aerosol-generating material for use in non-combustion aerosol delivery systems that does not contain any tobacco materials other than nicotine.

[0082] In some embodiments, it may be preferred that the fibrous material does not contain tobacco material, as certain consumers may prefer to inhale an aerosol generated from non-tobacco material while still containing nicotine.

[0083] As used herein, the term "tobacco material" refers to any material containing tobacco or its derivatives or substitutes. The tobacco material may be in any suitable form. The term "tobacco material" may include one or more of tobacco, tobacco derivatives, expanded tobacco, reconstituted tobacco, or tobacco substitutes. The tobacco material may include one or more of ground tobacco, tobacco fiber, cut tobacco, extruded tobacco, tobacco stems, tobacco lamina, and / or reconstituted tobacco. It is understood that nicotine extracts derived from tobacco material are not considered "tobacco material."

[0084] In some embodiments, the aerosol-forming material comprises a total fiber content of about 75% to about 95% by weight on a dry weight basis. For example, the total fiber content may be about 75% to about 90% by weight on a dry weight basis, such as about 75% to about 85%, e.g., about 75% to about 80% by weight. In some embodiments, the total fiber content of the aerosol-forming material is about 75% by weight on a dry weight basis.

[0085] In some embodiments, the fiber material comprises a first and a second fiber material. In some embodiments, the first fiber material is different from the second fiber material. When the first fiber material is different from the second fiber material, the properties of the aerosol-generating material, such as the generated aerosol, may be modified. For example, two different fiber materials may be combined that complement each other and provide a particularly pleasant / pleasant aerosol for the consumer.

[0086] In some embodiments, the first fibrous material comprises a plant material, and the second fibrous material comprises wood fiber / wood pulp. As used herein, wood fiber and wood pulp can be used to describe cellulose materials derived from cellulose materials that have little or no noticeable aroma. For example, the wood fiber and wood pulp used herein can be similar in nature to the wood fiber / wood pulp used to make paper.

[0087] In some embodiments, the ratio of the first fiber material to the second fiber material may be from about 10:1 to about 2:1. For example, the ratio may be from about 9:1 to about 3:1, such as from about 8:1 to about 4:1, such as from about 7:1 to about 4:1, such as from about 6:1 to about 4:1. In some embodiments, the ratio of the first fiber material to the second fiber material may be about 5:1.

[0088] In some embodiments, modifying the amount of a first fibrous material, e.g., comprising plant material, and a second fibrous material, e.g., comprising wood fiber / wood pulp, allows the aerosol to be modified / tailored to a particular desired profile. For example, increasing the relative amount of plant material compared to wood fiber / wood pulp may increase the amount of aroma compounds derived from the plant material in the aerosol.

[0089] The exact amount of organic acid used in the aerosol-forming material may be defined in several ways. For example, when high-nicotine tobacco is used (such as leaf tobacco), the amount of organic acid used may be defined in relation to the aerosol-forming material, e.g., as a weight percentage of the aerosol-forming material. Alternatively, the amount of organic acid may be defined in relation to the nicotine content of the aerosol-forming material, e.g., by reference to the ratio of moles of nicotine to moles of acid.

[0090] Without wishing to be bound by any particular theory, it is understood that when the amount of acid in the aerosol-generating material is as described herein, the aerosol generated by the aerosol-generating material contains a particularly beneficial ratio of nicotine in the gas phase to nicotine in the fine particle / liquid phase (nicotine (gas):nicotine (fine particle / liquid)). That is, the ratio of nicotine (gas):nicotine (fine particle / liquid) in the aerosol generated by the aerosol-generating material of the present invention provides an improved user experience and satisfaction. This is believed to be because the use of the amount of acid defined herein allows for optimal protonation of nicotine (e.g., by altering the ratio of free base nicotine to protonated nicotine). It is understood that protonation of nicotine in the aerosol-generating material alters the ratio of nicotine (gas):nicotine (fine particle / liquid) by increasing the amount of nicotine present in the fine particle / liquid phase. The aerosol generated by the aerosol-generating material described herein delivers an appropriate amount of nicotine to the user. Furthermore, users report that such aerosol-forming materials are neither too harsh nor harsh enough. Thus, the acid-containing aerosol-forming materials described herein produce aerosols with appropriate nicotine content and perceived harshness.

[0091] In some embodiments, the acid is selected from the group consisting of levulinic acid, lactic acid, benzoic acid, citric acid, 2-methylbutyric acid, or 2-methylvaleric acid. In some embodiments, the acid is benzoic acid. In some embodiments, the acid is levulinic acid.

[0092] In particular, it is understood that the total amount of acid defined herein represents the minimum amount of acid necessary to provide an adequate nicotine level and sensory experience: using an amount of acid less than that set forth herein will result in a suboptimal amount of nicotine reaching the user.

[0093] It is further understood that the total amount of acid defined herein represents the maximum amount of acid necessary to provide an adequate nicotine level and sensory experience. Using an amount of acid greater than the amount set forth herein does not result in better performance and is therefore considered wasteful.

[0094] In some embodiments, the aerosol-forming material includes an organic acid. The total amount of the acid is about 0.1% to about 5% by weight of the aerosol-forming material. For example, the total amount of the acid is about 0.1% to about 5% by weight, about 0.5% to about 5% by weight, about 1% to about 5% by weight, about 1.5% to about 5% by weight, about 2% to about 5% by weight, or about 2.5% to about 5% by weight of the aerosol-forming material. For example, the total amount of the acid is about 2.5% to about 5% by weight, about 2.5% to about 4.5% by weight, about 2.5% to about 4% by weight, about 2.5% to about 3.5% by weight, or about 2.5% to about 3% by weight of the aerosol-forming material.

[0095] In some embodiments, the aerosol-forming material comprises about 50%, about 60%, about 70%, about 80%, about 90%, about 100%, about 110%, about 120%, about 130%, about 140%, about 150%, about 160%, about 170%, about 180%, or about 190% to about 200% of the amount of acid relative to the moles of nicotine (i.e., moles of acid).

[0096] In some embodiments, the aerosol-forming material comprises an extract derived from botanical material.

[0097] In some embodiments, when the aerosol-generating material includes a plant material, the aerosol-generating material further includes an extract derived from the plant material. For example, as shown in FIG. 1 , the aerosol-generating material may be prepared by extracting the plant material and separating the extract and a fiber portion. The fiber portion may be combined with a second fiber material and processed to form a refined pulp, which may then be formed into a sheet. The extract, in addition to the nicotine, organic acid, and aerosol-forming agent, may be applied to the sheet, e.g., impregnated into the sheet, which is then dried. Reintroducing the extract from the plant material into the resulting aerosol-generating material allows aroma compounds from the plant material to be present in the aerosol-generating material. Processing the plant material to form an aerosol-generating material, for example, by a typical papermaking process, is believed to result in the loss of volatile flavor / aroma compounds. In particular, heating the plant material during the papermaking process may result in the loss of more volatile compounds, which are likely to be compounds that provide flavor and / or aroma to the plant material.

[0098] In some embodiments, the aerosol-generating material contains essentially 100% of the original plant material. For example, the fiber material includes all of the fiber portion of the original plant material, and the extract includes the entire extract removed from the original plant material. Utilizing all of the fiber portion and extract of the plant material is preferred because it reduces waste. Furthermore, the complete flavor profile of the original plant material is maintained in the resulting aerosol-generating material. This may be particularly preferred by consumers who may desire to consume an aerosol with a scent from the plant material.

[0099] In some embodiments, the aerosol-generating material comprises the extract in an amount of about 5% to about 15% by weight of the aerosol-generating material. For example, the extract may be present in an amount of about 6% to about 14% by weight of the aerosol-generating material, such as about 7% to about 13% by weight of the aerosol-generating material, such as about 8% to about 12% by weight of the aerosol-generating material, or about 10% to about 12% by weight of the aerosol-generating material. In some embodiments, the aerosol-generating material comprises the extract in an amount of about 11% by weight of the aerosol-generating material.

[0100] In some embodiments, the aerosol-forming material includes an aerosol-forming agent. The total amount of the aerosol-forming agent may be about 10% to about 20% by weight of the aerosol-forming material. In some embodiments, the total amount of the aerosol-forming agent is about 13% to about 16% by weight of the aerosol-forming material. In some embodiments, the total amount of the aerosol-forming agent material is about 15% by weight of the aerosol-forming material.

[0101] In this context, an "aerosol-forming agent" is an agent or material that facilitates the generation of an aerosol. Aerosol-forming agents may facilitate the generation of an aerosol by facilitating the initial vaporization and / or condensation of a gas into an inhalable solid and / or liquid aerosol. In some embodiments, aerosol-forming agents may improve the delivery of flavor from the aerosol-forming material.

[0102] The aerosol former materials have been found to improve the sensory performance of articles for use with aerosol-generating devices that include the aerosol-generating materials by aiding in the transport of compounds, such as flavor compounds, from the fiber material to the consumer. In some embodiments, the aerosol former materials described herein are flavored and / or include a flavor described herein.

[0103] Generally, any suitable aerosol-forming agent may be included in the aerosol-generating materials of the present invention. Suitable aerosol-forming agents include, but are not limited to, polyols such as sorbitol, glycerol, and glycols such as propylene glycol or triethylene glycol, non-polyols such as monohydric alcohols, high-boiling hydrocarbons, acids such as lactic acid, glycerol derivatives, esters such as diacetin, triacetin, triethylene glycol diacetate, triethyl citrate, or myristates, including ethyl and isopropyl myristates, and aliphatic carboxylic acid esters such as methyl stearate, dimethyl dodecanedioate, and dimethyl tetradecanedioate.

[0104] In some embodiments, the aerosol forming agent is selected from the group consisting of glycerol, propylene glycol, diethylene glycol, triethylene glycol, tetraethylene glycol, 1,3-butylene glycol, erythritol, mesoerythritol, ethyl vanillate, ethyl laurate, diethyl suberate, triethyl citrate, triacetin, diacetin mixtures, benzyl benzoate, benzyl phenylacetate, tributyrin, lauryl acetate, lauric acid, myristic acid, propylene carbonate, and mixtures thereof.

[0105] In some embodiments, the aerosol forming agent comprises glycerol in an amount of about 10% to about 90% by weight of the aerosol forming agent.

[0106] In some embodiments, the ratio of aerosol-forming agent to fiber material is about 1:7 to about 1:3, such as about 1:6 to about 1:4, e.g., about 1:5. When the ratio of aerosol-forming agent to fiber material is within this range, the aerosol-forming material exhibits favorable storage characteristics and produces favorable aerosols.

[0107] In some embodiments, the aerosol-generating material has a thickness of about 300 μm to about 400 μm. For example, the thickness may be about 310 μm to about 390 μm. For example, the thickness may be about 310 μm to about 380 μm. For example, the thickness may be about 320 μm to about 370 μm. For example, the thickness may be about 320 μm to about 360 μm. For example, the thickness may be about 320 μm to about 350 μm. For example, the thickness may be about 320 μm to about 340 μm. For example, the thickness may be about 325 μm to about 340 μm. For example, the thickness may be about 330 μm to about 340 μm.

[0108] In some embodiments, the aerosol-forming material has a water content of about 3% to about 8%. For example, the aerosol-forming material has a water content of about 4% to about 7%, e.g., about 5% to about 6%. In some embodiments, the aerosol-forming material has a water content of about 5%.

[0109] In some embodiments, the aerosol-forming material is applied to a volume of about 4 cm 3 / g ~ approx. 6cm 3 / g, for example, the aerosol-forming material may have a loading value of about 5 cm 3 / g.

[0110] In some embodiments, the aerosol-forming material exhibits a burst strength of about 10 KPa to about 30 KPa. In some embodiments, the aerosol-forming material exhibits a burst strength of about 15 KPa to about 25 KPa, e.g., about 20 KPa to about 25 KPa. In some embodiments, the burst strength is about 20 KPa.

[0111] In one embodiment, the nicotine salt is selected from nicotine benzoate, nicotine citrate, and nicotine lactate, and mixtures thereof.

[0112] In one embodiment, the aerosol-generating material is in the form of a rod. The aerosol-generating rod may have a total weight of about 250 mg to about 350 mg. In one embodiment, the aerosol-generating rod may be enclosed in a packaging material having an air permeability of less than 100 Coresta units. The aerosol-generating rod may have a circumference of at least about 19 mm, preferably about 19 mm to about 23 mm or about 21 mm. This may facilitate insertion of the article into the aerosol-generating device.

[0113] As used herein, the term "rod" is used to describe a generally cylindrical element of generally circular, oval, or elliptical cross section.

[0114] For the compositions described herein, when amounts are given in weight percent, this refers to a dry weight basis unless specifically indicated to the contrary. Therefore, any water that may be present in the aerosol-forming material or any of its components is completely ignored for purposes of determining weight percent. The water content of the aerosol-forming materials described herein may vary, for example, from 5% to 15% by weight. The water content of the aerosol-forming materials described herein may vary, for example, depending on the temperature, pressure, and humidity conditions under which the composition is maintained. The water content may be determined by Karl Fischer analysis, as known to those skilled in the art. However, for the avoidance of doubt, any components other than water are included in the weight of the aerosol-forming material, even if the aerosol-forming material is a component in a liquid phase, such as glycerol or propylene glycol.

[0115] In some embodiments, a system comprises an article described herein, wherein the aerosol-generating device is configured to receive at least a portion of the article including an aerosol-generating material, heat the portion of the article including the aerosol-generating material, and generate an aerosol from the aerosol-generating material.

[0116] In some embodiments, the aerosol-generating material may be disposed in an aerosol-generation section of the article. In use, the aerosol-generation section may exhibit a pressure drop of about 15 to about 40 mmH2O. In some embodiments, the aerosol-generation section exhibits a pressure drop across the aerosol-generation section of about 15 to about 30 mmH2O.

[0117] In some embodiments, the article comprises a tipping tip and a cylindrical rod of aerosol-forming material connected directly or indirectly to the tipping tip. A tipping tip wrapper, also referred to herein as tipping paper, is wrapped over a portion of the rod of aerosol-forming material along the entire length of the tipping tip and has adhesive on an inner surface of the tipping paper to connect the tipping tip and the rod.

[0118] In some embodiments, the tipping paper extends 5 mm over the rod of aerosol-generating material, but may alternatively extend 3 mm to 10 mm, or more preferably 4 mm to 6 mm, over the rod to provide a secure attachment between the tipping tip and the rod. The tipping paper may have a basis weight higher than that of the plug wrap used in the article for use with the aerosol-generating device, for example, 40 gsm to 80 gsm, more preferably 50 gsm to 70 gsm, in this example 58 gsm. It has been found that these basis weight ranges result in tipping paper with acceptable tensile strength while being flexible enough to wrap around the article and adhere to itself along the paper's longitudinal lap seam. The circumference of the tipping paper may be approximately 21 mm when wrapped around the tipping tip.

[0119] According to some embodiments, there is provided an article for use in an aerosol delivery system, the article comprising: an aerosol-forming material or substrate; a mouthpiece downstream of the aerosol-forming material; and a wrapping material, the wrapping material comprising a warming agent material, wherein a portion of the mouthpiece wrapping material proximate the downstream end of the mouthpiece contacts a consumer's lips during use.

[0120] The tipping wrap may be positioned to enclose the tipping in a region between the upstream and downstream ends of the tipping. The tipping wrap may be positioned such that when the article is inserted into the heating device, a portion of the tipping wrap is heated to the same or a similar temperature as the aerosol-forming material.

[0121] In some embodiments, the tipping wrapper comprises a warming agent material. The warming agent material may comprise a flavoring agent, as described herein. In some embodiments, the flavoring agent may be licorice, rose oil, vanilla, lemon oil, orange oil, mint flavor, preferably menthol and / or mint oil from any species of the genus Mentha, such as peppermint oil and / or spearmint oil, or lavender, fennel, or anise. In preferred embodiments, the warming agent material comprises a sugar and / or a sugar substitute (e.g., sucralose, acesulfame potassium, aspartame, saccharin, cyclamate, lactose, sucrose, glucose, fructose, sorbitol, or mannitol). Additionally or alternatively, the warming agent material may comprise a material that delivers a cooling, hot, or sour sensation to the consumer during use of the article.

[0122] In some embodiments, the warming agent material may include one or more of a pH adjuster, a stabilizer, and / or an antioxidant, which may help to extend the shelf life of the tipping wrapper and, therefore, the article.

[0123] The warming material may be encapsulated in an encapsulating material, for example, the warming material may be provided in the form of microcapsules that are applied to the packaging material.

[0124] The tipping wrapper may have an inner surface and an outer surface, and the warmth material may be present on at least a portion of the inner and / or outer surfaces of the wrapper. For example, the warmth material may be disposed on the outer surface of the tipping wrapper in an area that contacts the consumer's lips during use. By disposing the warmth material on the outer surface of the tipping wrapper, the warmth material may be transferred to the consumer's lips during use. By transferring the warmth material to the consumer's lips during use of the article, the organoleptic properties (e.g., taste) of the aerosol generated by the aerosol-generating substrate may be modified. For example, the warmth material may impart a flavor to the aerosol generated by the aerosol-generating substrate. The warmth material may be at least partially soluble in water so that it can be transferred to the user via the consumer's saliva.

[0125] Suitably, a relatively small amount of the warming material may be required to modify the sensory properties delivered to the consumer during use of the article, although this will depend to some extent on the properties of the warming material, as the minimum amount required to modify the sensory properties will vary between different warming materials. This can have the advantage that the addition of the warming material to the tipping wrap may not significantly increase the overall weight of the article. [Example]

[0126] [Table 1]

[0127] Aerosol-generating material was prepared as described above and formed into a rod suitable for use in the Glo Hyper device.

[0128] Test Method A Sample preparation Aerosol generation was performed using a Glo Hyper device. The rod was inserted into a heater, heated, and then the Glo device was smoked in a single-port smoker (SMK_057). The aerosol was captured on a solid-phase extraction (SPE) cartridge (FL-S34, FlavoLogic). Five rods were smoked in the same cartridge to compensate for variations in the composition of the Neostiks and the device.

[0129] Smoking parameters were as follows: Puff volume: 55ml Puff duration: 2 seconds Time between puffs: 30 seconds Number of puffs: 8

[0130] After the smoking procedure was completed, the aerosol was eluted from the cartridge with 10 ml of dichloromethane (DCM). The eluates from all treatments of one species were combined. After drying with sodium sulfate (anhydrous, Sigma-Aldrich), the pooled sample was concentrated to 250 μl using a Vigreux column.

[0131] AEDA The scent extract (100 μL) was serially diluted with DCM in a 1:1 ratio. Each dilution was analyzed by GC / olfactometry until no trace of odor was perceptible in the sniffing port.

[0132] The FD factor for each compound is the highest dilution at which the compound can still be perceived in the sniffing port. quantitative analysis Selected ion monitoring (SIM) was performed to quantify all identified compounds that showed FD coefficients of 512 or higher in AEDA.

[0133] To compensate for losses during sample preparation, 2,3-dimethoxytoluene was added as an internal standard after the elution step at a concentration of 7.54 μg / ml.

[0134] Calibration solutions were prepared for each identified compound. A response factor was calculated by dividing the peak area of ​​each compound by its concentration. This response factor was then correlated with the internal standard and plotted against the concentration of each standard compound to obtain a calibration curve from which the concentration of the compound in the sample could be calculated. All data processing was completed automatically using MassHunter Quantitative Analysis software. High-resolution gas chromatography / olfactometry Gas chromatography was performed using an Agilent 8890 gas chromatograph coupled to an Agilent 5977A mass spectrometer (MSD) and a Gerstel Olfactory detection port (ODP3).

[0135] The samples were separated in the following capillaries: FFAP, 30m x 0.25mm inner diameter (ID) and 0.5μm film

[0136] The sample was applied by the "cooled on-column" injection technique at 40°C. The flow rate of the carrier gas, helium, was set at 1.5 ml / min. At the end of the capillary, the effluent was split 1:1 to a flame ionization detector (FID) and a sniffing port by using two deactivated uncoated fused silica capillaries (20 cm x 0.25 mm φ). The FID and sniffing port were maintained at 250°C.

[0137] GC-O / MS conditions Sample application: Splitless, 250°C inlet temperature Detector: Mass spectrometer (MSD) Injection volume: 1μl Carrier gas: Helium, 1.5 ml / min constant flow Split ratio: 1:1 (v / v), uncoated capillary connecting splitter and detector ODP: 250℃ MSD: 250℃ Temperature gradient: 40℃ / 1 min6℃ / 分 200℃ 10℃ / 分 250℃ / 6.5 minutes

[0138] Determination of retention index (RI) The retention index was determined by linear interpolation according to the following formula:

number

[0139] The results in Table 1 show that star anise and rooibos produce aerosols with lower FD coefficients compared to eucalyptus. As a result, it can be concluded that aerosols produced from star anise or rooibos contain fewer aroma compounds and fewer strong / overpowering aroma compounds compared to eucalyptus.

[0140] The various embodiments described herein are presented solely to aid in the understanding and teaching of the claimed features. These embodiments are provided only as a representative sample of embodiments and are not exhaustive and / or exclusive. The advantages, embodiments, examples, functions, features, structures, and / or other aspects described herein should not be construed as limitations on the scope of the invention as defined by the claims or limitations on the equivalents of the claims, and it should be understood that other embodiments may be utilized and modifications may be made without departing from the scope of the claimed invention. Various embodiments of the present invention may suitably comprise, consist of, or consist essentially of any suitable combination of the disclosed elements, components, features, parts, steps, means, etc., other than those specifically described herein. Additionally, the present disclosure may include other inventions not currently claimed but which may be claimed in the future.

Claims

1. 1. An aerosol-forming material comprising a botanical material, the aerosol-forming material, when heated, producing an aerosol comprising a flavor dilution factor of less than about 10,000.

2. 10. The aerosol-forming material of claim 1, wherein the aerosol comprises a flavor dilution factor of about 5000 to about 6000.

3. 3. The aerosol-forming material of claim 1, wherein the plant material is selected from the list consisting of fennel, anise, mint, and rooibos, or mixtures thereof.

4. 4. The aerosol-forming material of claim 3, wherein the plant material is rooibos.

5. 4. The aerosol-forming material of claim 3, wherein the plant material is fennel, anise, or mint, or a mixture thereof.

6. The aerosol-forming material of any one of claims 1 to 5, further comprising a nicotine source and an aerosol-forming agent.

7. 7. The aerosol-forming material of claim 6, wherein the nicotine source is a nicotine salt, such as nicotine benzoate, nicotine levulinate, nicotine lactate, and nicotine citrate, or a mixture thereof.

8. The aerosol-forming material of any one of claims 1 to 5, further comprising nicotine, an organic acid, and an aerosol-forming agent.

9. 9. The aerosol-forming material of claim 8, wherein the organic acid is selected from the list consisting of lactic acid, levulinic acid, benzoic acid, citric acid, 2-methylbutyric acid, or 2-methylvaleric acid, and mixtures thereof.

10. 10. The aerosol-generating material of claim 6, wherein the aerosol-forming agent is selected from the list consisting of glycerol, propylene glycol, diethylene glycol, triethylene glycol, tetraethylene glycol, 1,3-butylene glycol, erythritol, mesoerythritol, ethyl vanillate, ethyl laurate, diethyl suberate, triethyl citrate, triacetin, diacetin mixtures, benzyl benzoate, benzyl phenylacetate, tributyrin, lauryl acetate, lauric acid, myristic acid, propylene carbonate, and mixtures thereof.

11. 1. An aerosol-forming material comprising a plant material that generates an aerosol when heated, the aerosol comprising vanillin, dimethyl trisulfide, and 2,3-butanedione.

12. 12. The aerosol-forming material of claim 11, wherein at least about 50% of the total aerosol comprises vanillin, dimethyl trisulfide, and 2,3-butanedione.

13. 1. An aerosol-forming material comprising a plant material that generates an aerosol when heated, the aerosol comprising vanillin, dimethyl trisulfide, and furaneol.

14. 1. An aerosol-forming material comprising a fibrous material capable of releasing volatile compounds when heated, the volatile compounds comprising vanillin, dimethyl trisulfide, and 2,3-butanedione.

15. 15. The aerosol-forming material of claim 14, wherein the vanillin, the dimethyl trisulfide, and the 2,3-butanedione comprise at least 50% of all volatile compounds emitted from the aerosol-forming material.

16. 1. An aerosol comprising at least one active substance, an organic acid, and at least one of vanillin, dimethyl trisulfide, and 2,3-butanedione, wherein the aerosol is generated by aerosolizing an aerosol-forming material comprising a plant material, the active substance, the organic acid, and an aerosol-forming agent.

17. 17. The aerosol of claim 16, wherein the active substance is nicotine.

18. 18. The aerosol according to claim 16 or 17, wherein the organic acid is lactic acid, benzoic acid, levulinic acid, citric acid, 2-methylbutyric acid, or 2-methylvaleric acid, and mixtures thereof.

19. 19. The aerosol of any one of claims 16 to 18, wherein the aerosol forming agent is selected from the list consisting of glycerol, propylene glycol, diethylene glycol, triethylene glycol, tetraethylene glycol, 1,3-butylene glycol, erythritol, mesoerythritol, ethyl vanillate, ethyl laurate, diethyl suberate, triethyl citrate, triacetin, diacetin mixtures, benzyl benzoate, benzyl phenylacetate, tributyrin, lauryl acetate, lauric acid, myristic acid, propylene carbonate, and mixtures thereof.

20. 20. The aerosol of any one of claims 16 to 19, wherein the plant material is selected from the list consisting of fennel, star anise, mint, and rooibos, and mixtures thereof.

21. 21. The aerosol of claim 20, wherein the plant material is rooibos.

22. 21. The aerosol of claim 20, wherein the plant material is fennel, star anise or mint, or a mixture thereof.

23. 17. The aerosol of claim 16, wherein the active substance is nicotine, the organic acid is benzoic acid, and the aerosol forming agent is glycerol.

24. 1. An aerosol-forming material for use in a delivery system, the aerosol-forming material comprising: a botanical material; at least one active substance; and an aerosol-forming agent; The aerosol-forming material generates an aerosol comprising vanillin, dimethyl trisulfide, and 2,3-butanedione.

25. A delivery system comprising an aerosol-forming material configured to generate an aerosol comprising an active agent and at least two of vanillin, dimethyl trisulfide, and 2,3-butanedione.

26. 26. The delivery system of claim 25, wherein the at least two of vanillin, dimethyl sulfide, and 2,3-butanedione comprise at least 35% of all compounds in the aerosol.

27. 1. A method for producing an inhalable aerosol comprising an active substance and at least two of vanillin, dimethyl trisulfide, and 2,3-butanedione, the method comprising heating a material comprising a plant material, the active substance, and an aerosol-forming agent.

28. Use of an aerosol-forming material comprising a plant material to generate an aerosol comprising vanillin, dimethyl trisulfide, and 2,3-butanedione.

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