Intraocular lens with haptic separation structure

Abstract

This specification discloses an intraocular lens comprising an optical portion and at least one haptic having a proximal and distal end coupled to the optical portion. The haptic includes a haptic internal passage extending over at least a portion of the haptic. The haptic may include one or more haptic isolation means disposed within the haptic internal passage. The one or more haptic isolation means may be configured to counteract or mitigate unintended shape changes caused by external energy directed at the haptic.

Description

Technical Field

[0001] Cross - reference to Related Applications This application claims priority to U.S. Patent Application No. 63 / 492,430, filed on March 27, 2023, and U.S. Patent Application No. 63 / 492,435, filed on March 27, 2023, the entire contents of which are incorporated herein by reference.

[0002] This disclosure generally relates to the field of intraocular lenses, and more particularly, to adjustable intraocular lenses.

Background Art

[0003] Cataract is a condition of the patient's eye that involves clouding of the normally clear lens. Cataracts develop as a result of aging, genetic factors, trauma, inflammation, metabolic diseases, or exposure to radiation. Age - related cataracts are the most common type of cataract. In the treatment of cataracts, the surgeon removes the native lens matrix from the patient's lens capsule and replaces it with an intraocular lens (IOL). Conventional IOLs provide one or more selected focal lengths that enable the patient to see in the distance. However, after cataract surgery, patients with a conventional IOL inserted often need glasses or other corrective eyewear to perform certain activities because the eye is unable to maintain a sharp image of an object or adjust (i.e., change its refractive power) to focus on an object as the distance changes.

[0004] With newer IOLs such as accommodative IOLs, the eye can regain at least some focusing ability. An adjustable intraocular lens (AIOL) utilizes forces available within the eye to re - focus the eye on a distant or near target by changing a portion of the optical system. In addition, it may be necessary to adjust the IOL after surgery or after implantation into the patient's eye. In some examples, the implanted IOL can be adjusted using laser treatment.

Summary of the Invention

Problems to be Solved by the Invention

[0005] However, such post-implantation adjustment procedures can also present challenges to the overall functionality of the implanted IOL. Therefore, solutions are needed to address these challenges. Furthermore, such solutions must be designed with clinical considerations in mind. [Means for solving the problem]

[0006] This application discloses an intraocular lens having a haptic isolation structure. In some embodiments, an intraocular lens is disclosed that includes an optical portion including an optical-fluidic chamber, and a haptic having a proximal end and a distal end coupled to the optical portion. The haptic may include an internal haptic passage extending through at least a portion of the haptic and in fluid communication with the optical-fluidic chamber. The haptic may comprise a plurality of haptic isolation means arranged within the internal haptic passage.

[0007] The haptic isolation means can be configured to limit the radial movement of the haptic radial outer wall to 0-10 microns in response to a laser beam directed at the haptic.

[0008] The haptic isolation means can be configured to counteract or mitigate unintended shape changes caused by laser light directed at the haptic.

[0009] In some embodiments, the haptic internal passage can be surrounded by a haptic radial outer wall, a haptic radial inner wall, a haptic front wall, and a haptic rear wall. The haptic isolation means can extend from the haptic front wall to the haptic rear wall of the haptic.

[0010] In some embodiments, each of the haptic isolation means may include a side surface, and none of the sides of the haptic isolation means physically contact the haptic radial inner wall or the haptic radial outer wall.

[0011] In some embodiments, the haptic isolation means can be positioned radially closer to the haptic radial inner wall than to the haptic radial outer wall. At least one side of the haptic isolation means closest to the haptic radial inner wall can be separated from the haptic radial inner wall by an internal isolation distance. In addition, another side of the haptic isolation means closest to the haptic radial outer wall can be separated from the haptic radial outer wall by an external isolation distance. The external isolation distance can be 1.5 × ~ 3 × greater than the internal isolation distance.

[0012] In some embodiments, at least one of the haptic separation means can be configured as a cylinder having a substantially circular cross-section.

[0013] In some embodiments, at least one of the haptic separation means may have a substantially rectangular cross-section, a substantially triangular cross-section, or a substantially elliptical cross-section.

[0014] In some embodiments, the haptic isolation means can be arranged as a curved colonnade within the haptic internal passageway.

[0015] In some embodiments, the haptic isolation means can be positioned at regular intervals along at least one section of the haptic internal passage.

[0016] In some embodiments, the haptic may include 3 to 20 haptic isolation means. In other embodiments, the haptic may include 20 to 30 haptic isolation means.

[0017] In some embodiments, each of the haptic separation means may include a separation means front end, a separation means rear end, and a separation means section between the separation means front end and the separation means rear end. The width or diameter of at least one of the separation means front end and the separation means rear end may be greater than the separation means section between the separation means front end and the separation means rear end.

[0018] In some embodiments, the width or diameter of at least one of the haptic separators can be kept constant along the length or height of the haptic separator.

[0019] In some embodiments, each of the haptic separation means may be measurable by the width or diameter and the length or height of the separation means. The length or height of at least one of the haptic separation means may be more than twice the width or diameter of the separation means.

[0020] In some embodiments, the haptic isolation means can be arranged in an arc. The haptic isolation means may include the most distal haptic isolation means, which acts as the endpoint of the arc, and the most proximal haptic isolation means. The arc formed by the haptic isolation means may be measurable by a central angle or arc angle. The central angle or arc angle can be between 70 and 74 degrees.

[0021] In some embodiments, the haptic may include at least one of an internal passage filler and an internal passage expander made of a composite material. The composite material may be configured to expand in response to receiving laser light directed at the internal passage filler or the internal passage expander.

[0022] In some embodiments, the haptic isolation means can be made of the same material as one or more walls of the haptic, but not of a composite material.

[0023] Also disclosed is an intraocular lens including an optical portion and a haptic having a proximal end and a distal end coupled to the optical portion. The haptic can include a haptic internal passage extending through at least a portion of the haptic. A plurality of haptic separation means can be arranged in an arc shape within the haptic internal passage.

[0024] In some embodiments, the haptic separation means can be configured to counteract or mitigate an unintended shape change caused by laser light directed at the haptic. For example, the haptic separation means can be configured to limit the radial movement of the outer wall of the haptic diameter to 0-10 micrometers in response to laser light directed at the haptic.

[0025] In some embodiments, the haptic includes at least one of an internal passage filler and an internal passage expander made of a composite material. The composite material can be configured to expand in response to receiving laser light directed at the internal passage filler or the internal passage expander. The haptic separation means is not made of a composite material.

[0026] In some embodiments, the haptic separation means can be made of the same material as one or more walls of the haptic and is not made of a composite material.

[0027] In some embodiments, the haptic internal passage can be surrounded by an outer wall of the haptic diameter, an inner wall of the haptic diameter, a front wall of the haptic, and a rear wall of the haptic. The haptic separation means can extend from the front wall of the haptic to the rear wall of the haptic.

[0028] In some embodiments, the haptic separation means can be positioned closer in the radial direction to the haptic radially inner wall than to the haptic radially outer wall. At least one of the haptic separation means can be separated from the haptic radially inner wall by an inner separation distance on the side closest to the haptic radially inner wall. In addition, another side of the haptic separation means closest to the haptic radially outer wall can be separated from the haptic radially outer wall by an outer separation distance. The outer separation distance can be 1.5× to 3× greater than the inner separation distance.

[0029] In some embodiments, each of the haptic separation means can include side surfaces, and none of the side surfaces of the haptic separation means physically contact the haptic radially inner wall or the haptic radially outer wall.

[0030] In some embodiments, at least one of the haptic separation means can be configured as a cylinder having a substantially circular cross-section.

[0031] In some embodiments, at least one of the haptic separation means can have a substantially rectangular cross-section, a substantially triangular cross-section, or a substantially elliptical cross-section.

[0032] In some embodiments, the haptic separation means can be arranged as a curved colonnade within the haptic internal passage.

[0033] In some embodiments, the haptic separation means can be positioned at regular intervals along at least one section of the haptic internal passage.

[0034] In some embodiments, the haptic can include 3 to 14 haptic separation means.

[0035] In some embodiments, each of the haptic separators may include a separator front end, a separator rear end, and a separator section between the separator front end and the separator rear end. The width or diameter of at least one of the separator front end and the separator rear end may be greater than the separator section between the separator front end and the separator rear end.

[0036] In some embodiments, the width or diameter of at least one of the haptic separators can be kept constant along the length or height of the haptic separator.

[0037] In some embodiments, each of the haptic separation means can be measured by the width or diameter and the length or height of the separation means. The length or height of at least one of the haptic separation means can be more than twice the width or diameter of the separation means.

[0038] In some embodiments, the haptic isolation means can be arranged in the shape of an arc. The haptic isolation means may include the most distal and most proximal haptic isolation means that act as the endpoints of the arc. The arc formed by the haptic isolation means can be measured by a central angle or arc angle. The central angle or arc angle can be between 70 and 74 degrees.

[0039] Also disclosed is an intraocular lens comprising an optical portion and a haptic having a proximal end and a distal end coupled to the optical portion. The haptic may include an internal haptic passage extending through at least a portion of the haptic. The haptic may include one or more isolation blocks disposed within the internal haptic passage. At least one of the one or more isolation blocks may have a non-circular cross-section.

[0040] In some embodiments, one or more isolation blocks can be configured to counteract or mitigate unintended shape changes caused by laser light directed at the haptic. For example, one or more isolation blocks can be configured to limit the radial movement of the haptic radial outer wall to 0-10 micrometers in response to laser light directed at the haptic.

[0041] In some embodiments, the haptic may include at least one of an internal passage filler and an internal passage expander made of a composite material. The composite material may be configured to expand in response to receiving laser light directed at the internal passage filler or the internal passage expander.

[0042] In some embodiments, one or more separation blocks can be made from the same material as one or more walls of the haptic, but not from a composite material.

[0043] In some embodiments, the haptic internal passage can be surrounded by a haptic radial outer wall, a haptic radial inner wall, a haptic front wall, and a haptic rear wall. One or more separation blocks can extend from the haptic front wall to the haptic rear wall of the haptic.

[0044] In some embodiments, each of one or more isolation blocks includes a side surface, and none of the side surfaces of one or more isolation blocks physically contact either the haptic radially inner wall or the haptic radially outer wall.

[0045] In some embodiments, one or more isolation blocks can be positioned radially closer to the haptic radial inner wall than to the haptic radial outer wall.

[0046] In some embodiments, the side of at least one of the separation blocks closest to the haptic radially inner wall can be separated from the haptic radially inner wall by an inner separation distance. Another side of the separation block closest to the haptic radially outer wall can be separated from the haptic radially outer wall by an outer separation distance. The outer separation distance can be 1.5 × ~ 3 × greater than the inner separation distance.

[0047] In some embodiments, at least one of the separation blocks may have a substantially oval cross-section.

[0048] In some embodiments, at least one of the separation blocks may have a substantially rectangular cross-section.

[0049] In some embodiments, at least one of the separation blocks may have a substantially elliptical cross-section.

[0050] In some embodiments, the haptic may include a plurality of isolation blocks arranged within the haptic internal passage. The isolation blocks may be positioned at regular intervals along at least one section of the haptic internal passage. [Brief explanation of the drawing]

[0051] [Figure 1A] Figure 1A shows a top view of one embodiment of an IOL including a haptic with haptic isolation means. [Figure 1B-1C] Figures 1B and 1C show cross-sectional views of the IOL along section AA in Figure 1A. [Figure 2A] Figure 2A shows a portion of the haptic pattern of an IOL without haptic isolation. [Figure 2B] Figure 2B is a graph showing the movement of the radial outer wall of a haptic without a haptic separation mechanism and the movement of the radial outer wall of a haptic equipped with a haptic separation mechanism. [Figure 3] Figure 3 shows a cross-sectional view of the haptic including the haptic separation means. [Figure 4A-4B] Figure 4A shows a perspective view of one embodiment of the haptic, including a haptic separation mechanism, with the front portion of the haptic removed for clarity. Figure 4B shows a top view of another embodiment of the haptic, including a haptic separation mechanism. [Figure 5A] Figure 5A shows a perspective view of the haptic, including the haptic separation mechanism. [Figure 5B] Figure 5B shows the haptic from Figure 5A with its distal end removed to illustrate a cross-section of part of the haptic. [Figure 6] Figure 6 shows a computed tomography (CT) scan image of a portion of a haptic, including a haptic separation device, in which the haptic radial outer wall has been digitally removed. [Figure 7A] Figure 7A shows a perspective view of another embodiment of the haptic, including a different type of haptic isolation means, with the front portion of the haptic removed for clarity. [Figure 7B] Figure 7B shows a perspective view of yet another embodiment of the haptic, including another type of haptic isolation means, with the front portion of the haptic removed for clarity. [Modes for carrying out the invention]

[0052] Figure 1A shows a top view of one embodiment of IOL 100 including a haptic 104 with haptic isolation means 105. In some embodiments, IOL 100 can be an adjustable IOL, such as an accommodative IOL (AIOL). IOL 100 can be implanted in a patient's eye to correct defocus aberration, corneal astigmatism, spherical aberration, or a combination thereof.

[0053] The IOL 100 may include an optical portion 102 and one or more haptics 104, including a first haptic 104A and a second haptic 104B coupled to the optical portion 102 and extending along the periphery therefrom. The IOL 100 can be positioned within the natural lens capsule after the natural lens has been removed.

[0054] The optical portion 102, when implanted in the natural lens capsule, can be configured to refract light entering the eye towards the retina. One or more haptics 104 can be configured to engage with the lens capsule and deform in response to ciliary muscle movements (e.g., muscle relaxation, muscle contraction, or a combination thereof) in connection with the reshaping of the lens capsule.

[0055] Each of the haptic 104 may include a haptic internal passage 106 extending through at least a portion of the haptic 104. For example, a first haptic 104A may include a first haptic internal passage 106A extending through at least a portion of the first haptic 104A, and a second haptic 104B may include a second haptic internal passage 106B extending through at least a portion of the second haptic 104B. The haptic internal passage 106 (for example, either the first haptic internal passage 106A or the second haptic internal passage 106B) may be in fluid communication with or fluidly connected to the optical part fluid chamber 108 within the optical part 102.

[0056] The optical partial fluid chamber 108 can be fluidly connected to one or more haptic internal passages 106 through one or more fluid channels 110. The fluid channels 110 can be conduits or passages that fluidly connect the optical partial fluid chamber 108 to the haptic internal passages 106. The fluid channels 110 can be spaced apart from each other. For example, a pair of fluid channels 110 can be spaced apart by about 0.1 mm to about 1.0 mm. In some embodiments, the diameter of each of the pair of fluid channels 110 can be about 0.4 mm to about 0.6 mm.

[0057] The haptic 104 can be coupled to the optical portion 102 at the reinforcing portion 112. The reinforcing portion 112 can serve as a haptic-optical portion boundary. A pair of fluid channels 110 can be defined or formed within a portion of the reinforcing portion 112.

[0058] As shown in Figure 1A, the optical partial fluid chamber 108 can communicate fluidly with the first haptic internal passage 106A through the first pair of fluid channels 110A. The optical partial fluid chamber 108 can also communicate fluidly with the second haptic internal passage 106B through the second pair of fluid channels 110B.

[0059] In some embodiments, the first pair of fluid channels 110A and the second pair of fluid channels 110B can be positioned substantially opposite the optical portion 102. The first pair of fluid channels 110A can be positioned substantially directly opposite the second pair of fluid channels 110B. The first pair of fluid channels 110A and the second pair of fluid channels 110B can be defined or extend through a portion of the optical portion 102. The first pair of fluid channels 110A and the second pair of fluid channels 110B can be defined or extend through a rear element 132 of the optical portion 102 (see, for example, Figures 1B and 1C).

[0060] Figure 1A also shows that each of the haptic 104 (for example, either the first haptic 104A or the second haptic 104B) may have a proximal mounting end 114 and a distal free end 116. A haptic fluid port 502 (see, for example, Figures 5A and 5B) can be defined at the proximal mounting end 114 of the haptic 104. The haptic fluid port 502 can serve as an opening for the haptic internal passage 106. When the haptic 104 is coupled to the optical portion 102, the fluid in the haptic internal passage 106 can exit the haptic internal passage 106 through the haptic fluid port 502 and flow through the haptic fluid channel 110 into the haptic fluid chamber 108. Similarly, the fluid in the optical partial fluid chamber 108 can exit the optical partial fluid chamber 108 through the pair of fluid channels 110 and flow through the haptic fluid port 502 into the haptic internal passage 106.

[0061] Each of the haptic 104 may include a haptic radial outer wall 118 and a haptic radial inner wall 120. The haptic radial outer wall 118 may be configured to face and contact the inner surface of the patient's lens capsule when the IOL 100 is implanted in the lens capsule. The haptic radial inner wall 120 may be configured to face the outer circumferential surface 122 of the optical portion 102.

[0062] The IOL 100 can be implanted or inserted into a patient's lens capsule after the original lens has been removed from that capsule. The patient's lens capsule is connected to zonular fibers that lead to the patient's ciliary muscle. The lens capsule is elastic and can be deformed via the zonular fibers by ciliary muscle movement. For example, when the ciliary muscle relaxes, the zonule stretches. This stretching causes the lens capsule to generally be pulled radially outward by an outward radial force. This stretching of the lens capsule lengthens it and creates space within it. When the patient's original lens is in the lens capsule, it usually flattens (in the anterior-posterior direction), thereby reducing its refractive power and enabling distance vision. In this configuration, the patient's original lens is said to be in a distance-view accommodative state or to have performed distance-view accommodation.

[0063] However, when the ciliary muscle contracts, as happens when the eye attempts to focus on a nearby object, the radially medial portion of the muscle moves radially inward, causing the zonule to relax. This relaxation of the zonule causes the elastic capsule to contract, applying a radially inward force to the lens within the capsule. When the patient's natal lens is within the capsule, it is usually more curved (for example, the anterior portion of the lens is more curved), thereby giving the lens greater refractive power and enabling the eye to focus on nearby objects. In this configuration, the patient's natal lens is said to be in a near-vision accommodation state, or to have performed near-vision accommodation.

[0064] When the IOL 100 is implanted in the patient's lens capsule, the haptic radial lateral wall 118 of the haptic 104 can directly engage with or physically contact with the portion of the lens capsule connected to the zonule or zonular fibers. Thus, the haptic radial lateral wall 118 can be configured to respond to forces that deform the lens capsule radially when the zonule relaxes and stretches as a result of ciliary muscle movement.

[0065] For example, when the ciliary muscle contracts, the peripheral region of the elastic lens capsule deforms, applying a radially inward force to each of the haptic radial outer walls 118 of the haptic 104. This causes the haptic radial outer walls 118 to deform or otherwise change shape, and this deformation or change in shape may reduce the volume of the haptic internal passage 106. When the volume of the haptic internal passage 106 decreases, the fluid within the haptic internal passage 106 is moved into or pushed into the optical partial fluid chamber 108.

[0066] The optical portion 102 can change shape in response to fluid entering the haptic fluid chamber 108 from the haptic internal passage 106. This increases the base power or base spherical power of the IOL 100, allowing the patient with the IOL 100 implanted in their eye to focus on near objects. In this state, the IOL 100 can be considered to have performed near-vision accommodation.

[0067] When the ciliary muscle relaxes, the peripheral region of the elastic lens capsule stretches radially outward, lengthening the lens capsule. The haptic radial outer wall 118 of the haptic 104 can be configured to return to its undeformed or unstressed state in response to this deformation of the lens capsule. This increases the volume of the haptic internal passage 106, or returns it to its undeformed volume. When the volume of the haptic internal passage 106 increases in this way, the fluid in the optical partial fluid chamber 108 can be drawn out of the optical partial fluid chamber 108, or otherwise flow out from there and return to the haptic internal passage 106. As previously described, the fluid moves out of the optical partial fluid chamber 108 to the haptic internal passage 106 through the same fluid channel 110 formed in the optical portion 102.

[0068] As described above, the optical portion 102 can change shape in response to fluid exiting the optical portion fluid chamber 108 and entering the haptic internal passage 106. This reduces the base power or base spherical power of the IOL 100, thereby enabling the patient with the IOL 100 implanted in the eye to focus on distant objects or to provide distance vision. In this state, the IOL 100 can be considered to have performed distance vision accommodation.

[0069] In some embodiments, the IOL 100 can be designed such that a gap 124 or void radially separates the haptic radial inner wall 120 of the haptic 104 from the outer surface 122 of the optical portion 102. This allows a portion of the haptic 104 to change shape or expand in response to external energy (such as laser energy) directed towards the haptic 104.

[0070] Figure 1A also shows that one or more parts of each haptic 104 can be fabricated from a composite material. As will be described in more detail in later sections, the composite material may include, or be partially fabricated from, an energy-absorbing component, multiple expandable components, and a cross-linked copolymer used to fabricate the rest of the haptic 104. The composite material parts of the haptic 104 may be configured to change shape (e.g., expand) in response to laser light 125 (see, for example, Figures 1B-1C) directed at the composite material. Depending on where the composite material is located or incorporated within each of the haptic 104, the composite material may function as an internal passage filler 126 to fill the space within the haptic internal passage 106 and / or an internal passage expander 128 to create a larger space within the haptic internal passage 106.

[0071] As will be described in more detail in a later section, when the laser beam 125 is irradiated onto the composite material configured as the internal passage filler 126, the composite material can expand. In this example, the expansion of the composite material reduces the volume of the haptic internal passage 106, allowing the fluid in the haptic internal passage 106 to move into the optical sub-fluid chamber 108. This allows the optical sub-component 102 to change shape (for example, the front or rear elements of the optical sub-component 102 can be made more curved), which leads to an increase in the base degree of the optical sub-component 102.

[0072] Alternatively, when the laser beam 125 is irradiated onto the composite material configured as the internal passage expander 128, the composite material can expand, and in this example, the expansion of the composite material increases the volume of the haptic internal passage 106, allowing the fluid in the optical partial fluid chamber 108 to be drawn into the haptic internal passage 106. This also allows the optical portion 102 to change shape (for example, by making the front or rear elements of the optical portion 102 less curved, i.e., flattened), resulting in a decrease in the base degree of the optical portion 102.

[0073] As will be described in more detail in subsequent sections, each of the haptic 104 may include a plurality of haptic isolation means 105, which can counteract or mitigate the effects of unintended shape changes or deformations caused by the irradiation of the haptic 104 with laser light 125.

[0074] Although AIOLs are illustrated and described in this disclosure, any reference to AIOLs may also refer to one of the AIOLs discussed and illustrated in the following U.S. publications, namely U.S. Patent Application Publication No. 2021 / 0100652, U.S. Patent Application Publication No. 2021 / 0100650, U.S. Patent Application Publication No. 2020 / 0337833, U.S. Patent Application Publication No. 2018 / 0153682 and the following issued U.S. patents: U.S. Patent No. 11,426,270, U.S. Patent No. 10,433,949, U.S. Patent No. 10,299,913, U.S. Patent No. 10,195,020, and U.S. Patent No. 8,968,396, the entirety of which is incorporated herein by reference.

[0075] Figures 1B and 1C show cross-sectional views of IOL 100 as seen along the cutting line AA in Figure 1A. As shown in Figures 1B and 1C, the optical portion 102 may include a front element 130 and a rear element 132. The fluid chamber 108 of the fluid-filled optical portion can be defined between the front element 130 and the rear element 132.

[0076] The front element 130 may include a front optical surface 134 and a front inner surface 136 opposite to the front optical surface 134. The rear element 132 may include a rear optical surface 138 and a rear inner surface 140 opposite to the rear optical surface 138. Any of the front optical surface 134, the rear optical surface 138, or any combination thereof can be considered and referred to as an optical outer surface. The front inner surface 136 and the rear inner surface 140 can face the optical partial fluid chamber 108. At least a portion of the front inner surface 136 and at least a portion of the rear inner surface 140 can serve as the chamber wall of the optical partial fluid chamber 108.

[0077] As shown in Figures 1B and 1C, the optical portion 102 may have a lens optical axis 142 extending in the front-to-back direction through the center of the optical portion 102. The lens optical axis 142 may extend through the centers of both the front element 130 and the rear element 132.

[0078] The thickness of the front element 130 can be made thicker at or near the lens optical axis 142 than at its periphery. In some embodiments, the thickness of the front element 130 can be gradually increased from the periphery toward the lens optical axis 142.

[0079] In certain embodiments, the thickness of the front element 130 at or near the lens optical axis 142 can be about 0.45 mm to about 0.55 mm. In these and other embodiments, the thickness of the front element 130 near the periphery can be 0.20 mm to about 0.40 mm. Furthermore, the front inner surface 136 of the front element 130 can have a smaller curvature than the front optical surface 134, i.e., it can be flattened.

[0080] The thickness of the rear element 132 can be greater than that of the portion radially outward from the lens optical axis 142, at or near the lens optical axis 142, until it reaches the raised peripheral portion 144 of the rear element 132. The thickness of the rear element 132 can be gradually reduced from the lens optical axis 142 to the portion radially outward from the lens optical axis 142 (but before reaching the raised peripheral portion 144). As shown in Figures 1B and 1C, the thickness of the rear element 132 can again be increased from the portion radially inward from the portion radially outward of the raised peripheral portion 144.

[0081] In certain embodiments, the thickness of the rear element 132 at or near the lens optical axis 142 can be approximately 0.45 mm to approximately 0.55 mm. In these and other embodiments, the thickness of the rear element 132 radially outward from the lens optical axis 142 (but before reaching the raised peripheral portion 144) can be approximately 0.20 mm to approximately 0.40 mm. The thickness of the rear element 132 near the radially outward portion of the raised peripheral portion 144 can be approximately 1.00 mm to approximately 1.15 mm. Furthermore, the rear inner surface 140 of the rear element 132 can have a smaller curvature than the rear optical surface 138, i.e., it can be flattened.

[0082] The optical portion 102 may have a base degree or a base spherical degree. The base degree of the optical portion 102 may be configured to change based on the internal fluid pressure in the optical portion fluid chamber 108 filled with fluid. The base degree of the optical portion 102 may be configured to increase or decrease as the fluid enters or exits the optical portion fluid chamber 108 filled with fluid.

[0083] The base degree of the optical portion 102 can be configured to increase as the fluid enters the fluid-filled optical portion fluid chamber 108 from the haptic internal passage 106, as shown by the curved dashed arrow in Figure 1B. For example, the front element 130 of the optical portion 102 can be configured to increase its curvature in response to the fluid entering the optical portion fluid chamber 108. Similarly, the rear element 132 of the optical portion 102 can be configured to increase its curvature in response to the fluid entering the optical portion fluid chamber 108. In another embodiment, both the front element 130 and the rear element 132 can be configured to increase their curvature in response to the fluid entering the optical portion fluid chamber 108.

[0084] The base degree of the optical portion 102 can be configured to decrease as the fluid exits or is drawn out of the fluid-filled optical portion fluid chamber 108 and enters the haptic internal passage 106, as shown by the curved dashed arrow in Figure 1C. For example, the front element 130 of the optical portion 102 can be configured to decrease its curvature (i.e., become flattened) in response to the fluid exiting the optical portion fluid chamber 108. Similarly, the rear element 132 of the optical portion 102 can be configured to decrease its curvature (i.e., become flattened) in response to the fluid exiting the optical portion fluid chamber 108. In another embodiment, both the front element 130 and the rear element 132 can be configured to decrease their curvature in response to the fluid exiting the optical portion fluid chamber 108.

[0085] In Figures 1B and 1C, curved dashed arrows indicate that the fluid enters and exits the optical partial fluid chamber 108 through the haptic internal passage 106. However, it should be noted that the fluid enters and exits the optical partial fluid chamber 108 through the fluid channel 110 and the opening 146 defined along the rear element 132. The opening 146 can be a hole or opening defined along the rear element 132, serving as the end of the fluid channel 110. If the IOL 100 includes a pair of fluid channels 110, the pair of openings 146 serving as the ends of the fluid channels 110 can be spaced approximately 0.1 mm to 1.0 mm apart from each other.

[0086] As shown in Figures 1B and 1C, one or more parts of the IOL 100 can be fabricated from a composite material, which is designed to respond to external energy such as laser light 125. For example, one or more parts of each of the haptic 104 of the IOL 100 can be fabricated from a composite material.

[0087] In some embodiments, the laser beam 125 can be a green laser beam with a wavelength of approximately 480 nm to 650 nm (e.g., 532 nm). In these embodiments, the laser beam 125 can be a neodymium-doped yttrium aluminum garnet (Nd:YAG) laser.

[0088] In other embodiments, the laser light 125 may have a wavelength of 1030 nm to 1035 nm. In these embodiments, the laser generating the laser light 125 may be a femtosecond laser.

[0089] Depending on where the composite material is positioned or incorporated within each of the haptics 104, and the plasticity of the composite material, the composite material can function as an internal passage filler 126 or an internal passage expander 128.

[0090] For example, the internal passage filler 126 can be a portion of the haptic 104 made of a composite material, and the composite material is designed to decrease the volume of the haptic internal passage 106 in response to external energy (e.g., laser light 125) directed towards the internal passage filler 126. The internal passage expander 128 can be a portion of the haptic 104 made of a composite material, and the composite material is designed to increase the volume of the haptic internal passage 106 in response to external energy (e.g., laser light 125) directed towards the internal passage expander 128.

[0091] As shown in Figures 1B and 1C, each of the haptic 104 may include a channel 148. The channel 148 may be defined within a portion of the haptic radial inner wall 120. For example, a portion of the channel 148 may extend into the haptic radial inner wall 120. The channel 148 may be in fluid communication with the haptic internal passage 106, or may be considered as part of the haptic internal passage 106.

[0092] In some embodiments, the internal passage filler 126 can be located behind the channel 148. In these embodiments, the internal passage filler 126 can replace or function as the rear portion of the haptic radial inner wall 120. The internal passage filler 126 can also be located radially inward of the portion of the haptic internal passage 106 that is not the channel 148.

[0093] At least a portion of the internal passage filler 126 can be in fluid communication with the channel 148. For example, at least a portion of the front part or layer of the internal passage filler 126 can be in fluid communication with the channel 148 or otherwise exposed thereto.

[0094] As shown in Figures 1B and 1C, in some embodiments, the radially outer side of the internal passage filler 126 does not have fluid communication with the haptic internal passage 106. In these embodiments, the radially outer side of the internal passage filler 126 is separated from the haptic internal passage 106 by the portion of the haptic 104 that is not made of composite material.

[0095] The internal passage expansion member 128 can be positioned radially inward of the channel 148. The internal passage expansion member 128 can also be positioned in front of the internal passage filler 126. More specifically, for example, the internal passage expansion member 128 can be positioned in front of the radially inward portion of the internal passage filler 126.

[0096] In some embodiments, the internal passage extension member 128 can be positioned within the channel 148. In these embodiments, the internal passage extension member 128 can be positioned at the innermost radial end of the channel 148. For example, the haptic radial inner wall 120 can be tapered as it approaches the optical portion 102. The internal passage extension member 128 can be positioned at the innermost radial end of the channel 148, near the tapered end of the haptic radial inner wall 120.

[0097] As shown in Figures 1B and 1C, the radially outer surface of the internal passage expander 128 can be in fluid communication with the channel 148 and the haptic internal passage 106. In some embodiments, the internal passage expander 128 does not extend over the entire radially innermost portion of the haptic radial inner wall 120. In these embodiments, the portion of the haptic 104 that is not made of composite material acts as the radially innermost portion of the haptic radial inner wall 120, allowing the internal passage expander 128 to be separated from the outer surface 122 of the optical portion 102.

[0098] In some embodiments, the internal passage expansion member 128 can be connected to or otherwise joined to the internal passage filler member 126. In these and other embodiments, the internal passage expansion member 128 and the internal passage filler member 126 can be different parts of the same composite material or refer to each other. For example, the internal passage filler member 126 may be substantially in the shape of a curved bellows, and the internal passage expansion member 128 may be substantially in the shape of a rectangular parallelepiped extending from the front of this bellows.

[0099] Those skilled in the art will understand that, although different colored shadows are used in the figure to distinguish between the internal passage filler 126 and the internal passage expander 128 (i.e., a darker shaded pattern is used to indicate the internal passage expander 128, and a lighter shaded pattern is used to indicate the internal passage filler 126), both the internal passage filler 126 and the internal passage expander 128 can be made from the same composite material, or they can refer to different parts / features of the same composite material block.

[0100] In other embodiments, the internal passage filler 126 and the internal passage expander 128 can be made from different types of composite materials. In these embodiments, the internal passage filler 126 can be made from a first type of composite material, and the internal passage expander 128 can be made from a second type of composite material. In certain embodiments, the internal passage filler 126 and the internal passage expander 128 can be made from composite materials of different colors. For example, the composite material may contain energy-absorbing components such as energy-absorbing pigments or dyes.

[0101] As a more specific example, either the internal passage filler 126 or the internal passage expander 128 can be made from a composite material containing a black energy-absorbing pigment, such as graphitized carbon black. In this example, if one of the internal passage filler 126 or the internal passage expander 128 is made from a composite material containing graphitized carbon black, the other can be made from another type of composite material containing a red energy-absorbing pigment, such as an azo dye (e.g., Disperse Red 1 dye).

[0102] As shown in Figure 1B, external energy, such as laser light 125, can be directed towards the internal passage filler 126 to cause at least a portion of the internal passage filler 126 to expand and increase in size. For example, this expansion may manifest as a bulge extending or protruding from the internal passage filler 126. For example, if the laser light 125 is directed towards a front portion or layer of the internal passage filler 126 that is in fluid communication with the channel 148 or otherwise in contact with the channel, the bulge can extend from the front portion into the channel 148. Since the channel 148 is in fluid communication with (or is considered to be part of) the haptic internal passage 106, the volume of the haptic internal passage 106 may decrease in response to the formation of the bulge. This can push the fluid in the haptic internal passage 106 into the optical partial fluid chamber 108 or otherwise displace it. As a result, in response to the laser stimulation being directed towards the internal passage filler 126, at least one of the forward element 130 and the rear element 132 can increase its curvature, and the base degree of the optical portion 102 can increase.

[0103] External energy, such as laser light 125 (e.g., laser pulses), can be directed towards the internal passage expander 128 to cause at least a portion of it to expand and increase its size. As will be described in more detail in a later section, this expansion can manifest as an expansion of the channel 148. For example, when laser light 125 is directed towards the internal passage expander 128, the internal passage expander 128 can increase in size and expand the channel 148. Since the channel 148 is in fluid communication with (or can be considered part of) the haptic internal passage 106, the volume of the haptic internal passage 106 can increase in response to the growth of the internal passage expander 128. This allows fluid from within the optical partial fluid chamber 108 to be drawn into the haptic internal passage 106. As a result, in response to the laser beam 125 (e.g., a laser pulse) being directed towards the internal passage expansion material 128, at least one of the forward element 130 and the rear element 132 can reduce its curvature, and the base degree of the optical portion 102 can be reduced.

[0104] As will be described in more detail in subsequent sections, each of the haptic 104 may include a plurality of haptic isolation means 105, which can counteract or mitigate the effects of unintended shape changes or deformations caused by the irradiation of the haptic 104 with laser light 125.

[0105] In some embodiments, the fluid in the optical partial fluid chamber 108 and the haptic internal passage 106 can be an oil. More specifically, in certain embodiments, the fluid in the optical partial fluid chamber 108 and the haptic internal passage 106 can be a silicone oil or fluid. For example, the fluid can be a silicone oil produced in part with diphenylsiloxane. In other embodiments, the fluid can be a silicone oil produced in part with a ratio of 2 units of dimethylsiloxane to 1 unit of diphenylsiloxane. More specifically, in some embodiments, the fluid can be a silicone oil produced in part with diphenyltetramethylcyclotrisiloxane or a copolymer of diphenylsiloxane and dimethylsiloxane. In yet another embodiment, the fluid can be a silicone oil containing a branched polymer.

[0106] The fluid (e.g., silicone oil) may be refractive index-matched with the lens body material used to fabricate the optical portion 102. When the fluid is refractive index-matched with the lens body material, the entire optical portion 102 containing the fluid can function as a single lens. For example, the fluid may be selected to have a refractive index of about 1.48 to 1.53 (or about 1.50 to 1.53). In some embodiments, the polydispersity index of the fluid (e.g., silicone oil) may be about 1.2 to 1.3. In other embodiments, the polydispersity index of the fluid (e.g., silicone oil) may be about 1.3 to 1.5. In other embodiments, the polydispersity index of the fluid (e.g., silicone oil) may be about 1.1 to 1.2. Other exemplary fluids are described in U.S. Patent Application Publication No. 2018 / 0153682, which is incorporated herein by reference in its entirety.

[0107] The optical portion 102 can be made in part from a deformable or flexible material. In some embodiments, the optical portion 102 can be made in part from a deformable or flexible polymer material. For example, the front element 130, the rear element 132, or a combination thereof can be made in part from a deformable or flexible polymer material. One or more haptics 104 (e.g., a first haptic 104A, a second haptic 104B, or a combination thereof) can be made in part from the same deformable or flexible material as the optical portion 102. In other embodiments, one or more haptics 104 can be made in part from a material different from that of the optical portion 102.

[0108] In some embodiments, the optical portion 102 may include, or be made of, a lens body material. The lens body portion may be made of a crosslinked copolymer containing a copolymer blend. The copolymer blend may include alkyl acrylates or methacrylates, fluoroalkyl (meth)acrylates, and phenyl-alkyl acrylates. It is intended by this disclosure, and will be understood as such, that these types of acrylic crosslinked copolymers may generally be copolymers of multiple acrylates, methacrylates, or combinations thereof, and the term “acrylate” as used herein should be understood to mean acrylates, methacrylates, or combinations thereof interchangeably unless otherwise specified. The crosslinked copolymer used to make the lens body material may contain about 3% to 20% (wt%) of alkyl acrylate, about 10% to 35% (wt%) of fluoroalkyl acrylate, and about 50% to 80% (wt%) of phenyl-alkyl acrylate. In some embodiments, the crosslinked copolymer comprises, or can be fabricated in part from, n-butyl acrylate as an alkyl acrylate, trifluoroethyl methacrylate as a fluoroalkyl acrylate, and phenylethyl acrylate as a phenylalkyl acrylate. More specifically, the crosslinked copolymer used in the fabrication of the lens body material may contain n-butyl acrylate in an amount of about 3% to 20% (wt%) (e.g., about 12% to 16%), trifluoroethyl methacrylate in an amount of about 10% to 35% (wt%) (e.g., about 17% to 21%), and phenylethyl acrylate in an amount of about 50% to 80% (wt%) (e.g., about 64% to 67%).

[0109] The final composition of the crosslinked copolymer used in the manufacture of the lens body material may also include a crosslinker, i.e., a crosslinking agent, such as ethylene glycol dimethacrylate (EGDMA). For example, the final composition of the crosslinked copolymer used in the manufacture of the lens body material may also include a crosslinker, i.e., a crosslinking agent (e.g., EGDMA) in an amount of about 1.0%. The final composition of the crosslinked copolymer used in the manufacture of the lens body material may also include an initiator, i.e., a starter (e.g., Percadox 16) and a UV absorber.

[0110] One or more haptic 104 may contain or be fabricated in part from haptic material. The haptic material may contain or be fabricated in part from a crosslinked copolymer containing a copolymer blend. The copolymer blend may contain alkyl acrylates, fluoroalkyl acrylates, and phenyl-alkyl acrylates. For example, the crosslinked copolymer used in the fabrication of the haptic material may contain alkyl acrylates in an amount of about 10% to 25% (wt%), fluoroalkyl acrylates in an amount of about 10% to 35% (wt%), and phenyl-alkyl acrylates in an amount of about 50% to 80% (wt%). In some embodiments, the crosslinked copolymer used in the production of haptic materials may contain about 10% to 25% (wt%) (e.g., about 19% to 23%) of n-butyl acrylate, about 10% to 35% (wt%) (e.g., about 14% to 18%) of trifluoroethyl methacrylate, and about 50% to 80% (wt%) (e.g., about 58% to 62%) of phenylethyl acrylate. The final composition of the crosslinked copolymer used in the production of haptic materials may also contain about 1.0% of a crosslinker, i.e., a crosslinking agent, such as EGDMA. The final composition of the crosslinked copolymer used in the production of haptic materials may also contain several photoinitiators, i.e., photoinitiators (e.g., camphorquinone, 1-phenyl-1,2-propanedione, and 2-ethylhexyl-4-(dimethylamino)benzoic acid).

[0111] In some embodiments, the refractive index of the lens body material can be approximately 1.48 to approximately 1.53. In certain embodiments, the refractive index of the lens body material can be approximately 1.50 to approximately 1.53 (for example, approximately 1.5178).

[0112] The front element 130 can be attached to the rear element 132 via adhesive 150 or an adhesive layer, or otherwise bonded. The adhesive layer can be substantially annular in shape. The adhesive 150 or adhesive layer can be placed on the peripheral edge of the optical portion 102 between the front element 130 and the rear element 132. For example, the adhesive 150 can be placed on the raised peripheral portion 144 of the rear element 132.

[0113] The adhesive 150 or adhesive layer may contain or be made in part from a biocompatible adhesive. The adhesive 150 or adhesive layer may contain or be made in part from a biocompatible polymer adhesive.

[0114] The adhesive 150 or adhesive layer may contain or be made in part from a crosslinked polymer precursor formulation. The crosslinked polymer precursor formulation may contain or be made in part from a copolymer blend, a hydroxyl-functionalized acrylic monomer, and a photoinitiator.

[0115] The copolymer blend may include alkyl acrylates (e.g., about 41% to about 45% (wt%) of n-butyl acrylate), fluoroalkyl acrylates (e.g., about 20% to about 24% (wt%) of trifluoroethyl methacrylate), and phenylalkyl acrylates (about 28% to about 32% (wt%) of phenylethyl acrylate). The hydroxyl-functionalized acrylic monomer may be 2-hydroxyethyl acrylate (HEA). A photoinitiator may be used to accelerate the curing of the adhesive. For example, the photoinitiator may be Darocur 4265 (a 50 / 50 blend of diphenyl(2,4,6-trimethylbenzoyl)phosphine oxide and 2-hydroxy-2-methylpropiophenone).

[0116] In some embodiments, the same adhesive 150 used to bond the front element 130 to the rear element 132 can also be used to bond or fix one or more haptics 104 to the optical portion 102.

[0117] In some embodiments, the composite material may include a composite substrate, an energy-absorbing component, and a plurality of expandable components. As described above, one or more parts of each haptic 104 can be made from the composite material.

[0118] The composite substrate can be made of a hydrophobic acrylic material. For example, the composite substrate can be made of phenylethyl acrylate (PEA), phenylethyl methacrylate (PEMA), or a combination thereof.

[0119] In one exemplary embodiment, the composite substrate may include a methacrylate-functional or methacrylic-functional crosslinked polymer and a reactive acrylic monomer diluent such as lauryl methacrylate (n-dodecyl methacrylate or SR313) and ADMA. By controlling the amount of lauryl methacrylate (SR313) relative to ADMA, the overall corresponding hardness (i.e., more ADMA) or softness (i.e., more SR313) of the cured composite material can be controlled. The methacrylate-functional or methacrylic-functional crosslinked polymer can be prepared using a crosslinked polymer precursor formulation.

[0120] The crosslinked polymer precursor formulation may include the same copolymer blend used to produce the optical portion and haptic. The copolymer blend may include alkyl acrylates or methacrylates (e.g., n-butyl acrylate), fluoroalkyl (meth)acrylates (e.g., trifluoroethylene methacrylate), and phenyl-alkyl acrylates (e.g., phenylethyl acrylate). For example, the copolymer blend may contain about 41% to about 45% (wt%) of n-butyl acrylate, about 20% to about 24% (wt%) of trifluoroethyl methacrylate, and about 28% to about 32% (wt%) of phenylethyl acrylate. The crosslinked polymer precursor formulation may include, or be partially prepared from, a copolymer blend, a hydroxyl-functionalized acrylic monomer (e.g., HEA), and a photoinitiator (e.g., Darocur 4265 or a 50 / 50 blend of diphenyl(2,4,6-trimethylbenzoyl)-phosphine oxide and 2-hydroxy-2-methylpropiophenone).

[0121] The composite substrate may contain approximately 50% to approximately 65% ​​(e.g., approximately 55% to approximately 60%) (wt%) of methacrylate-functional or methacrylic-functional crosslinked polymer (as described above), approximately 32% to approximately 38% (e.g., approximately 32.70%) (wt%) of the reactive acrylic monomer diluent lauryl methacrylate (SR313), and approximately 5% to approximately 9% (e.g., approximately 7.30%) (wt%) of the reactive acrylic monomer diluent adamantyl methacrylate (ADMA).

[0122] The composite material can be fabricated in several steps. The first step may include preparing an uncolored composite substrate. The second step may include mixing the composite substrate with an energy-absorbing component, an expansive component, and an initiator such as one or more photoinitiators, thermal initiators, or a combination thereof. The third step may include placing the uncured composite material at a desired location within the haptic 104 (for example, near the channel 148) and curing the composite material in place.

[0123] For example, an uncolored composite substrate can be mixed with an energy-absorbing component such as a dye (e.g., Disperse Red 1 dye) or a pigment (graphitized carbon black). Energy-absorbing components will be discussed in more detail later.

[0124] In some embodiments, the expandable component may constitute about 5.0% to about 15.0% by weight of the final composition of the composite material. More specifically, the expandable component may constitute about 8.0% to about 12.0% by weight (e.g., about 10.0%) of the final composition of the composite material. In these and other embodiments, the energy-absorbing component may constitute about 0.044% to about 0.44% by weight (or about 0.55%) of the final composition of the composite material.

[0125] The photoinitiator may be Omnirad 2022 (bis(2,4,6-trimethylbenzoyl)phenyl-phosphine oxide / 2-hydroxy-2-methyl-1-phenyl-propan-1-one). The photoinitiator may constitute about 1.30% by weight of the final composition of the composite material. In addition, the composite material may also contain a thermal initiator. The thermal initiator may constitute about 1.00% by weight of the final composition of the composite material. In some embodiments, the thermal initiator may be a dialkyl peroxide such as Luperox® peroxide. In other embodiments, the thermal initiator may be Perkadox.

[0126] In some embodiments, the energy-absorbing component absorbs external energy (e.g., laser energy), converts this energy into heat, and conducts this energy to the composite substrate, causing it to expand.

[0127] In some embodiments, the expandable component may be an expandable microsphere comprising an expandable thermoplastic shell and a foaming agent contained within the expandable thermoplastic shell. The microsphere may be configured to expand such that the diameter of at least one of the microspheres can increase to about 2 × of its original diameter. In other embodiments, the microsphere may be configured to expand such that the diameter of at least one of the microspheres can increase to about 4 × of its original diameter, i.e., four times its original diameter. In yet another embodiment, the microsphere may be configured to expand such that the diameter of at least one of the microspheres can increase to about 2 × to about 4 × (or about 3.5 ×) of its original diameter. For example, the initial diameter of the microsphere may be about 12 μm. In response to external energy being applied to or directed at the composite material, or in response to energy being transferred to or transmitted to the microsphere, the diameter of the microsphere may increase to about 40 μm.

[0128] The volume of at least one of the microspheres can be configured to expand by about 10 × to about 50 × in response to external energy being applied to or directed to the composite material, or in response to energy being transferred to or transmitted to the microsphere.

[0129] In some embodiments, the blowing agent can be an expandable fluid such as an expandable gas. More specifically, the blowing agent can be a branched-chain hydrocarbon. For example, the blowing agent can be isopentane. In other embodiments, the blowing agent may be cyclopentane, pentane, or a mixture of cyclopentane, pentane, and isopentane, or may include such mixture.

[0130] Each of the expandable components may include a thermoplastic shell. The thickness of the thermoplastic shell may change as the size of the expandable component increases. More specifically, the thickness of the thermoplastic shell may decrease as the size of the expandable component increases. For example, if the expandable component is an expandable microsphere, the thickness of the thermoplastic shell (i.e., its thickness in the radial direction) may decrease as the diameter of the expandable microsphere increases.

[0131] In some embodiments, the thermoplastic shell can be made partly from a nitrile or acrylonitrile copolymer. For example, the thermoplastic shell can be made partly from acrylonitrile, styrene, butadiene, methyl acrylate, or a combination thereof.

[0132] As mentioned above, the expandable component can constitute approximately 8.0% to 12% by weight of the final composition of the composite material. The expandable component can constitute approximately 10% by weight of the final composition of the composite material.

[0133] The expandable component can be dispersed in the composite substrate that constitutes the bulk of the composite material, or distributed by other means. The composite substrate can act as a matrix for holding or supporting the expandable component. The composite material can expand in response to the expansion of the expandable component (e.g., thermoplastic microspheres). For example, the volume of the composite material can increase in response to the expansion of the expandable component.

[0134] The composite material also includes an energy-absorbing component. In some embodiments, the energy-absorbing component can be an energy-absorbing dye.

[0135] In certain embodiments, the energy-absorbing dye can be an energy-absorbing dye. For example, the energy-absorbing dye can be an azo dye. In some embodiments, the azo dye can be a red azo dye, such as Disperse Red 1 dye. In other embodiments, the azo dye can be an orange azo dye such as Disperse Orange dye (e.g., Disperse Orange 1), a yellow azo dye such as Disperse Yellow dye (e.g., Disperse Yellow 1), a blue azo dye such as Disperse Blue dye (e.g., Disperse Blue 1), or a combination thereof.

[0136] In additional embodiments, the energy-absorbing dye may be a pigment or may include one. For example, the energy-absorbing dye may be graphitized carbon black as a pigment or may include one.

[0137] Similar to the expansion component, the energy-absorbing component can be dispersed within the composite substrate that constitutes the bulk of the composite material, or distributed in other ways. The composite substrate can serve as a matrix for holding or supporting the expansion component and the energy-absorbing component.

[0138] As mentioned above, the energy-absorbing component can constitute approximately 0.025% to 1.0% by weight (or more specifically, approximately 0.045% to 0.45%) of the final composition of the composite material.

[0139] Energy-absorbing components (e.g., azo dyes, graphitized carbon black, or combinations thereof) can absorb or capture external energy (e.g., light energy, or more specifically, laser light) applied to or directed at the composite material. The energy-absorbing components can absorb or capture external energy and convert this energy into thermal energy or heat, or transfer it to the expandable component.

[0140] The thermoplastic outer shell can soften and begin to flow when thermal energy is transferred to or transmitted to the expandable component. The thermoplastic outer shell of the expandable component can then thin, i.e., begin to decrease in thickness, in response to the transfer or transmission of thermal energy to the expandable component. As the thermoplastic outer shell softens and begins to decrease in thickness, the blowing agent in the expandable component can expand. The blowing agent can also expand in response to the transfer or transmission of thermal energy or heat to the expandable component. The expansion of the blowing agent can cause the expandable component (e.g., thermoplastic microspheres) to expand, i.e., increase in volume. This ultimately causes the composite material to expand or increase in volume.

[0141] As described above, the external energy can be laser light 125, and the energy-absorbing component can absorb or capture the laser light 125 directed at the composite material, convert the light energy into thermal energy or heat, or transfer it to the expandable component. The foaming agent in the expandable component can expand or be activated in response to the thermal energy or heat. The expandable component and ultimately the composite material can expand or increase in volume in response to this light energy being directed at the composite material.

[0142] Figure 2A shows a portion of the haptic 200 of an IOL without haptic isolation means. The IOL including the haptic 200 shown in Figure 2A may be similar to the IOL 100 shown in Figures 1A-1C, but this IOL differs in that it does not have haptic isolation means 105 supporting the haptic internal passage 202 of the haptic 200.

[0143] The haptic 200 may include a haptic front wall 204, a haptic rear wall 206, a haptic radial outer wall 208, and a haptic radial inner wall 210, which surround the haptic internal passage 202. The internal passage channel 212 may extend radially into the haptic radial inner wall 210. Furthermore, the haptic 200 may include an internal passage filler 214, an internal passage expander 216, or a combination thereof. The internal passage filler 214 and the internal passage expander 216 may be made of composite material and may function similarly to the internal passage filler 126 and the internal passage expander 128, respectively.

[0144] Figure 2A shows the effect after the laser beam 125 (e.g., a laser pulse from a 532 nm laser) is directed onto the internal passage filler 214, the internal passage expander 216, or a combination thereof. For example, the laser beam 125 can be directed onto one or more target sites 218 shown in Figure 2A.

[0145] As shown in Figure 2A, the composite material constituting the internal passage filler 214 and the internal passage expander 216 can expand in response to the addition of laser energy. This expansion of the composite material may also unintentionally cause other parts of the haptic 200 to change shape, expand, or bend. For example, this expansion of the composite material may unintentionally affect the size of the haptic internal passage 202. Furthermore, this expansion of the composite material may unintentionally cause the haptic to bend, resulting in asymmetrical bending of the optical portion of the IOL.

[0146] The dashed outline of the haptic 200 shows the haptic front wall 204, haptic rear wall 206, and haptic radial inner wall 210 before laser energy is applied. As can be seen in Figure 2A, after the laser beam 125 is directed to or delivered to the internal passage filler 214, internal passage expander 216, or a combination thereof, the haptic front wall 204 can expand forward and the haptic rear wall 206 can expand backward. In some cases, this expansion of the haptic front wall 204 and haptic rear wall 206 can cause the haptic radial outer wall 208 to be pulled radially or translated in the direction of the optical portion (see Figure 2B). Such unintended shape changes can cause undesirable side effects such as unexpected changes in refractive power and reduced accommodative performance.

[0147] Therefore, the technical challenge facing the applicant is how to counteract or mitigate the effect of unintended haptic shape changes caused by irradiation with laser light 125 without interfering with the ability to fine-tune the base power of the IOL by laser-induced fluid pressure changes (i.e., without interfering with the ability to adjust the refractive power of the implanted lens), and without interfering with the sensitivity of the fluid-filled haptic 104 to radial forces applied by the lens capsule as a result of ciliary muscle movement (i.e., without interfering with the lens's accommodative ability). The technical solution discovered and developed by the applicant is the haptic isolation means 105 disclosed herein.

[0148] Figure 2B is a graph showing measurements taken for the movement of the haptic radial outer wall 208 of a haptic 200 without the haptic isolation means 105, and for the movement of the haptic radial outer wall 118 of a haptic 104 with the haptic isolation means 105, in response to the laser beam 125 being directed towards such a haptic.

[0149] Figure 2B shows that the movement or displacement of the haptic radial outer wall was measured using an integrated data acquisition system (IDAS). Predictions of such movement were also made using finite element analysis (FEA) modeling. For both types of haptics, laser beam 125 (not shown in Figure 2B) was directed or otherwise delivered to the internal passage filler of such haptics.

[0150] Figure 2B shows the outer contours of the two haptics before laser irradiation with dashed lines, and the outer contours after laser irradiation with solid lines. As can be seen from the depiction of these outer contours, the two haptics showed different responses to irradiation with laser light 125.

[0151] In the case of the haptic 200 without a haptic separation mechanism, the laser beam 125 directed towards the internal passage expansion material (not shown in Figure 2B) caused the haptic front wall 204 of the haptic 200 to expand forward, and the haptic rear wall 206 of the haptic 200 to expand backward. In most cases, this expansion caused the haptic radial outer wall 208 of the haptic 200 to be pulled radially or translated in the direction of the optical portion (not shown in Figure 2B).

[0152] As can be seen from the graph in Figure 2B, the haptic radial outer wall 208 of haptic 200 displaced approximately 0.03 mm, or 30 micrometers, radially inward on average (negative values ​​on the graph indicate radially inward movement). In some cases, the haptic radial outer wall 208 of haptic 200 was measured to have moved radially inward by up to approximately 0.10 mm, or 100 micrometers. This level of movement was considered problematic because it would negate the desired expansion of the haptic internal passage.

[0153] In haptic 104 equipped with haptic separation means 105, a different response to laser light 125 was observed. For such haptic 104, IDAS measurements performed after irradiating its internal passage expansion material (not shown in Figure 2B) with laser light 125 revealed that the degree of movement of the haptic radial outer wall 208 of haptic 104 was much smaller.

[0154] As can be seen from the graph in Figure 2B, the haptic radial outer wall 118 of haptic 104 displaced approximately 0.01 mm or 10 micrometers on average in the radially outward direction (positive values ​​on the graph indicate radially outward movement). In some cases, the haptic radial outer wall 118 of haptic 104 showed no movement. In most cases, the haptic radial outer wall 118 of haptic 104 moved only 0 mm to 0.01 mm, or 10 micrometers, in either the radially outward or radially inward direction.

[0155] Thus, Figure 2B shows that the haptic isolation means 105 can be effective in limiting any radial movement of the haptic radial outer wall 118 in response to the laser beam 125 being directed towards the haptic 104. For example, the haptic isolation means 105 can be effective in limiting any radial movement of the haptic radial outer wall 118 to 0 to 0.01 mm (i.e., 10 micrometers) in response to the laser beam 125 directed towards the haptic 104.

[0156] Figure 3 shows a cross-sectional view of one embodiment of a haptic 104 having a haptic isolation means 105 positioned within a haptic internal passage 106. The haptic isolation means 105 can be configured to maintain the shape of the haptic internal passage 106 in response to laser energy (e.g., laser light 125) being irradiated onto or delivered to the haptic 104 in order to adjust the base degree of the optical portion 102.

[0157] The haptic isolation means 105 can extend from the haptic front wall 300 to the haptic rear wall 302. As shown in Figure 3, the haptic isolation means 105 can be positioned in the front-rear direction so that it is substantially parallel to the optical axis 142 of the optical portion 102 (see, for example, Figures 1B and 1C).

[0158] In other embodiments conceivable by this disclosure, although not shown, the haptic isolation means 105 can be tilted or inclined. For example, the haptic isolation means 105 can be positioned at an angle with respect to the optical axis 142.

[0159] As shown in Figure 3, the haptic isolation means 105 can be positioned radially closer to the haptic radial inner wall 120 than to the haptic radial outer wall 118 (see also Figures 1B and 1C). This allows the haptic isolation means 105 to counteract or mitigate the effect of unintended haptic shape changes caused by irradiation with laser light 125 without substantially affecting the sensitivity of the haptic radial outer wall 118 to radial forces applied to the lens capsule by ciliary muscle movement.

[0160] For example, the haptic separation means 105 (or the side of the haptic separation means 105 closest to the haptic radial inner wall 120) can be separated from the haptic radial inner wall 120 by an inner separation distance 304. The haptic separation means 105 (or the other side of the haptic separation means 105 closest to the haptic radial outer wall 118) can be separated from the haptic radial outer wall 118 by an outer separation distance 306. The outer separation distance 306 can be greater than the inner separation distance 304.

[0161] In some embodiments, the outer separation distance can be 1.5 to 3 times (3x) larger than the inner separation distance 304. In other embodiments, the outer separation distance can be 1.2 to 1.4 times (1.4x) larger than the inner separation distance 304. In yet another embodiment, the outer separation distance can be 3 to 4 times (4x) larger than the inner separation distance 304.

[0162] In some embodiments, the haptic separation means 105 can be positioned between the haptic radial inner wall 120 and a center line that bisects the haptic internal passage 106 radially. For example, the haptic separation means 105 can be positioned radially inward of the center line that bisects the haptic internal passage 106 radially.

[0163] In some embodiments, the haptic separation means 105 may be cylindrical or columnar. In other embodiments, the haptic separation means 105 may be elongated cuboid or square prism, elongated frustocone, triangular prism, or elongated oval (i.e., having an elliptical cross-section).

[0164] In some embodiments, the haptic separation means 105 can be made from the same material as the rest of the haptic 104. For example, the haptic separation means 105 can be made from the same cross-linked copolymer as the wall of the haptic 104. In certain embodiments, the haptic separation means 105 can be integrated with the rest of the haptic 104.

[0165] In some embodiments, the haptic separation means 105 can be formed or created during the haptic casting process. For example, the entire haptic 104, including the haptic separation means 105, can be formed by injection molding.

[0166] The haptic separation means 105 may have a height 308 and a width 310 or diameter (if the haptic separation means 105 is cylindrical).

[0167] In some embodiments, the height 308 of the separating means may be about 1.5 mm to 2.00 mm. For example, the height 308 of the separating means can be about 1.75 mm to 1.85 mm (e.g., about 1.84 mm).

[0168] In some embodiments, the width 310 or diameter of the separating means may be about 0.20 mm to 0.60 mm. For example, the width 310 of the separating means may be about 0.30 mm to 0.50 mm (e.g., about 0.35 mm).

[0169] In other embodiments, the width 310 or diameter of the separation means can be greater than 0.60 mm, depending on the width of the haptic internal passage 106. In yet another embodiment, the width 310 or diameter of the separation means can be less than 0.20 mm, depending on the width of the haptic internal passage 106.

[0170] In certain embodiments, the height 308 or length of the separating means may be approximately twice the width 310 or diameter of the separating means. In other embodiments, the height 308 or length of the separating means may be more than twice the width 310 or diameter of the separating means.

[0171] In some embodiments, the ratio of the height 308 of the separating means to the width 310 or diameter of the separating means can be about 3:1 to 10:1. For example, the ratio of the height 308 of the separating means to the width 310 or diameter of the separating means can be about 4:1 to 6:1 (for example, about 5:1).

[0172] As shown in Figure 3, the width 310 of the separation means can remain constant along the length or height of the haptic separation means 105. In other embodiments, the width 310 of the separation means can be greater than the rest of the haptic separation means 105 near the ends of the haptic separation means 105 (i.e., closer to the haptic front wall 300 and the haptic rear wall 302).

[0173] In other embodiments, each of the haptic separators 105 may include a separator front end 312, a separator rear end 314, and a separator section 316 between the separator front end 312 and the separator rear end 314. In these embodiments (see, for example, Figure 6), the width or diameter of at least one of the separator front end 312 and the separator rear end 314 may be greater than the separator section 316 between the separator front end 312 and the separator rear end 314. For example, the haptic separator 105 may be wider or spread out at the separator front end 312 and / or the separator rear end 314.

[0174] Although Figure 3 shows only one haptic isolation means 105 within the haptic internal passage 106, the disclosure suggests that the haptic internal passage 106 may include a plurality of haptic isolation means 105 positioned along at least a portion of the length or section of the haptic internal passage 106.

[0175] One technical challenge faced by the applicant is how to counteract or mitigate the effects of unintended haptic shape changes caused by irradiation with laser light 125. The technical solution discovered and developed by the applicant is the haptic isolation means 105 disclosed herein, which is located within the haptic internal passage 106 and is positioned radially closer to the haptic radial inner wall 120 than to the haptic radial outer wall 118 (see also Figures 1B, 1C, 4A and 4B).

[0176] The haptic isolation means 105 can function as a three-dimensional bracket or support column to prevent unintended deformation of the haptic internal passage 106. For example, the haptic isolation means 105 can prevent unintended expansion and / or contraction of the haptic internal passage 106 caused by the application of laser energy to the composite material.

[0177] Figure 4A shows a perspective view of one embodiment of the haptic 104, with the front portion of the haptic 104 removed for clarity, and including a plurality of haptic isolation means 105. As previously mentioned, the haptic isolation means 105 can be configured to counteract or mitigate any unintended shape changes caused by the laser beam 125 directed at the internal passage filler 126 and / or internal passage expander 128 in order to fine-tune the base degree of the IOL 100.

[0178] As shown in Figure 4A, the haptic separation means 105 can be designed as cylindrical or cylindrical supports, each having a substantially circular cross-section.

[0179] In other embodiments, at least a portion of the haptic separation means 105 may have a substantially triangular, rectangular, or other polygonal cross-section. In yet another embodiment, at least a portion of the haptic separation means 105 may have a substantially elliptical cross-section.

[0180] As shown in Figure 4A, the haptic isolation means 105 can be positioned within the haptic internal passage 106. The haptic isolation means 105 can be positioned or arranged such that none of its sides are in physical contact with the haptic radial outer wall 118 or the haptic radial inner wall 120. Furthermore, as shown in Figure 4A, the haptic isolation means 105 can be positioned or arranged radially closer to the haptic radial inner wall 120 than to the haptic radial outer wall 118.

[0181] Furthermore, as shown in Figure 4A, multiple haptic separation means 105 can be arranged as a curved colonnade within the haptic internal passage 106. For example, the haptic separation means 105 can be arranged in an arc-shaped configuration.

[0182] In some embodiments, the haptic isolation means 105 can be positioned at regular intervals along the length of the haptic internal passage 106. In other embodiments, the haptic isolation means 105 can be positioned at variable distances from one another along the length of the haptic internal passage 106.

[0183] Figure 4A shows a haptic 104 including 13 haptic isolation means 105, but in this disclosure, it is conceivable that one haptic 104 may include 3 to 20 haptic isolation means 105 (or 20 to 30 haptic isolation means 105).

[0184] The haptic separation means 105 can be made from the same haptic material used to fabricate the haptic wall. As shown in Figure 4A, the haptic separation means 105 is not made from the composite material used to fabricate the internal passage filler 126 and / or internal passage expander 128.

[0185] Figure 4B shows a top view of another embodiment of the haptic 104 including haptic isolation means 105. In the embodiment shown in Figure 4B, the haptic 104 includes seven haptic isolation means 105. As previously stated, a single haptic 104 may include any number of haptic isolation means 105 from three to a maximum of 20 (or 20 to 30) haptic isolation means 105.

[0186] As shown in Figure 4B, the haptic isolation means 105 can be arranged in the shape of an arc 400 or in an arrangement of arcs. When arranged as an arc 400, the haptic isolation means 105 may include the most distal haptic isolation means 402 and the most proximal haptic isolation means 404. The arc 400 can be measured by a central angle or arc angle 406 extending from the most distal haptic isolation means 402 to the most proximal haptic isolation means 404. In some embodiments, this central angle or arc angle can be 70 to 74 degrees.

[0187] Figure 5A shows a perspective view of one embodiment of the haptic 104 of the IOL 100, including the haptic separation means 105. Figure 5B shows the haptic 104 with its distal end 116 removed to show a cross-section of the haptic 104.

[0188] As shown in Figures 5A and 5B, the end of the proximal mounting end 114 of the haptic 104 can be placed on a substantially flat interface 500. The flat interface 500 allows the haptic 104 to be bonded or otherwise connected to a corresponding interface (also a flat surface) protruding from the reinforcing portion 112 of the optical portion 102. In some embodiments, the haptic 104 can be bonded or connected to the optical portion 102 via the same biocompatible adhesive 150 used to bond the front element 130 to the rear element 132.

[0189] The corresponding interface can extend radially from the optical portion 102. For example, the corresponding interface can extend radially beyond the outer circumferential surface 122 of the optical portion 102 (for example, extending radially beyond approximately 10 micrometers to 1.0 mm beyond the outer circumferential surface 122 of the optical portion 102).

[0190] Figures 5A and 5B also show that a substantially flat interface 500 can define a haptic fluid port 502. The haptic fluid port 502 can be an opening that serves as the proximal end of the haptic internal passage 106. When the flat interface 500 of the haptic 104 is coupled to the corresponding interface of the optical portion 102, the haptic fluid port 502 can be fluid-connected to, or in fluid communication with, one or more outward-facing openings that serve as the termination of the fluid channel 110. Fluid entering the optical fluid chamber 108 (e.g., silicone oil) can pass through the haptic fluid port 502, exit the haptic internal passage 106, and enter the fluid channel 110. Furthermore, fluid leaving the optical fluid chamber 108 can pass through the haptic fluid port 502 and enter the haptic internal passage 106.

[0191] Although Figure 5B shows only one haptic isolation means 105 within the haptic internal passage 106, the present disclosure suggests that the haptic internal passage 106 may include a plurality of haptic isolation means 105 positioned along the length or section of the haptic internal passage 106. In some embodiments, the haptic isolation means 105 can be positioned at regular intervals along the length of the haptic internal passage 106. In other embodiments, the haptic isolation means 105 can be positioned at variable distances from one another along the length of the haptic internal passage 106.

[0192] Figure 6 shows a computed tomography (CT) scan image of a portion of the haptic 104, including multiple haptic separation means 105. In this CT scan image, the haptic radial outer wall 118 of the haptic 104 has been digitally removed for better visibility.

[0193] As shown in Figure 6, the haptic isolation means 105 is positioned within the haptic internal passage 106 and extends substantially axially (i.e., substantially parallel to the lens optical axis 142). The haptic isolation means 105 can extend from the haptic front wall 300 to the haptic rear wall 302.

[0194] As shown in this exemplary embodiment, the haptic isolation means 105 can be substantially cylindrical in shape, so that each of the haptic isolation means 105 has a substantially circular cross-section. When the haptic isolation means 105 is arranged as a cylinder, it can be arranged as a curved colonnade within the haptic internal passage 106.

[0195] In some embodiments, the haptic isolation means 105 can be positioned at regular intervals along the length of the haptic internal passage 106. In other embodiments, the distance separating directly adjacent haptic isolation means 105 can vary along the length of the haptic internal passage 106.

[0196] Furthermore, Figure 6 shows that one or more widths or diameters of the haptic separation means 105 can be larger or wider than the rest of the haptic separation means 105 near the ends of the haptic separation means 105 (i.e., closer to the haptic front wall 300 and the haptic rear wall 302).

[0197] In other embodiments, the width or diameter of one or more of the haptic separation means 105 may be the same along the overall height or overall length of the haptic separation means 105.

[0198] Figure 6 shows a haptic 104 including 10 haptic isolation means 105. However, according to this disclosure, one haptic 104 may include 3 to 20 haptic isolation means 105 (or 20 to 30 haptic isolation means 105).

[0199] Figures 7A and 7B show perspective views of additional embodiments of the haptic 104, including a plurality of haptic separation means 105 in the form of separation blocks 700 or thick plates. In Figures 7A and 7B, the front portions of each of the haptic 104 are not shown for clarity.

[0200] In some embodiments, the separation block 700 may have a non-circular cross-section. For example, each of the separation blocks 700 may have a cross-sectional profile 702 including a block length dimension 704 and a block width dimension 706. The block length dimension 704 of the cross-sectional profile 702 may be greater than the block width dimension 706.

[0201] In some embodiments, the block length dimension 704 of the cross-sectional profile 702 can be twice the block width dimension 706. In other embodiments, the block length dimension 704 of the cross-sectional profile 702 can be more than twice the block width dimension 706 (e.g., 3 × ~ 5 ×).

[0202] Each of the separation blocks 700 may also have a block height dimension 708. In some embodiments, the block height dimension 708 can be about 1.5 mm to 2.00 mm. For example, the block height dimension 708 can be about 1.75 mm to 1.85 mm (e.g., about 1.84 mm).

[0203] In some embodiments, the block width dimension 706 can be approximately 0.20 mm to 0.60 mm. For example, the block width dimension 706 can be approximately 0.30 mm to 0.50 mm (for example, approximately 0.35 mm).

[0204] In another embodiment, the block width dimension 706 can be greater than 0.60 mm depending on the width of the haptic internal passage 106. In yet another embodiment, the block width dimension 706 can be less than 0.20 mm depending on the width of the haptic internal passage 106.

[0205] In certain embodiments, the block height dimension 708 can be approximately twice the block width dimension 706. In other embodiments, the block height dimension 708 can be more than twice the block width dimension 706.

[0206] In some embodiments, the ratio of the block height dimension 708 to the block width dimension 706 can be approximately 3:1 to 10:1. For example, the ratio of the block height dimension 708 to the block width dimension 706 can be approximately 4:1 to 6:1 (for example, approximately 5:1).

[0207] In some embodiments, at least one cross-sectional profile 702 of the separation block 700 may be substantially oval (i.e., a rectangle with semicircular ends). In other embodiments, at least one cross-sectional profile 702 of the separation block 700 may be substantially elliptical. In yet another embodiment, at least one cross-sectional profile 702 of the separation block 700 may be substantially rectangular or a rectangle with rounded corners.

[0208] Similar to the haptic separation means 105 shown in Figures 1A-1C, 3, 4A-4B, 5B, and 6, the separation block 700 can be configured to counteract or mitigate any unintended shape changes caused by the laser beam 125 directed at the internal passage filler 126 and / or internal passage expander 128 in order to fine-tune the base degree of the IOL 100.

[0209] As shown in Figures 7A and 7B, the separation block 700 can be positioned within the haptic internal passage 106. The separation block 700 can be positioned or arranged such that none of its sides are in physical contact with the haptic radial outer wall 118 or the haptic radial inner wall 120. Furthermore, as shown in Figures 7A and 7B, the separation block 700 can be positioned or arranged radially closer to the haptic radial inner wall 120 than to the haptic radial outer wall 118.

[0210] Furthermore, as shown in Figures 7A and 7B, multiple separation blocks 700 can be arranged in an arc formation or as a curved colonnade within the haptic internal passage 106.

[0211] In some embodiments, the separation blocks 700 can be positioned at regular intervals along the length of the haptic internal passage 106. In other embodiments, the separation blocks 700 can be positioned at variable distances from each other along the length of the haptic internal passage 106.

[0212] Figure 7A shows a haptic 104 containing three isolation blocks 700, and Figure 7B shows a haptic 104 containing four isolation blocks 700. However, in this disclosure, one haptic 104 may contain 3 to a maximum of 20 isolation blocks 700 (or 20 to 30 isolation blocks 700).

[0213] The separation block 700 can be made from the same haptic material used to fabricate the haptic wall. As shown in Figures 7A and 7B, the separation block 700 is not made from the composite material used to fabricate the internal passage filler 126 and / or internal passage expander 128.

[0214] This disclosure also covers the following:

[0215] Article 1. An intraocular lens comprising an optical portion including an optical fluid chamber, a haptic having a proximal end and a distal end coupled to the optical portion, the haptic including an internal haptic passage extending through at least a portion of the haptic and in fluid communication with the optical fluid chamber, and a plurality of haptic isolation means disposed within the internal haptic passage.

[0216] Section 2. The intraocular lens of Section 1, wherein the haptic internal passage is surrounded by the haptic radial lateral wall, the haptic radial medial wall, the haptic anterior wall, and the haptic posterior wall.

[0217] Section 3. The intraocular lens of Section 2, wherein the haptic isolation means is configured to restrict any radial movement of the haptic radially lateral wall in response to a laser beam being directed at the haptic to 0-10 microns.

[0218] Section 4. The haptic separation means is the intraocular lens of Section 2, extending from the anterior haptic wall to the posterior haptic wall.

[0219] Section 5. The intraocular lens of Section 2, wherein each of the haptic isolation means includes a side surface, and none of the side surfaces of the haptic isolation means are in physical contact with the haptic radial medial wall or the haptic radial lateral wall.

[0220] Section 6. The intraocular lens of Section 2, wherein the haptic separation means is positioned radially closer to the haptic radial medial wall than to the haptic radial lateral wall.

[0221] Section 7. The intraocular lens of Section 6, wherein at least one side of the haptic isolation means closest to the haptic radial medial wall is separated from the haptic radial medial wall by an medial isolation distance, and another side of the haptic isolation means closest to the haptic radial lateral wall is separated from the haptic radial lateral wall by an lateral isolation distance, the lateral isolation distance being 1.5 × ~ 3 × greater than the medial isolation distance.

[0222] Section 8. The intraocular lens of Section 1, wherein at least one of the haptic separation means is configured as a cylinder.

[0223] Section 9. The intraocular lens of Section 8, wherein the cylinder has a substantially circular cross-section.

[0224] Paragraph 10. The intraocular lens of paragraph 1, wherein at least one of the haptic separation means has a substantially rectangular cross-section, a substantially triangular cross-section, or a substantially elliptical cross-section.

[0225] Clause 11. The intraocular lens of Clause 1, wherein multiple haptic isolation means are arranged as a curved colonnade within the haptic internal passage.

[0226] Clause 12. The intraocular lens of Clause 1, wherein a plurality of haptic isolation means are arranged at regular intervals along at least one section of the haptic internal passage.

[0227] Section 13. The intraocular lens of Section 1, comprising 3 to 20 haptic separation means.

[0228] Paragraph 14. The intraocular lens of paragraph 1, wherein each haptic isolation means includes an isolation means front end, an isolation means rear end, and an isolation means section between the isolation means front end and the isolation means rear end, and the width or diameter of at least one of the isolation means front end and the isolation means rear end is greater than the isolation means section between the isolation means front end and the isolation means rear end.

[0229] Paragraph 15. The intraocular lens of paragraph 1, wherein the width or diameter of at least one of the haptic isolation means remains constant along the length or height of the haptic isolation means.

[0230] Paragraph 16. The intraocular lens of paragraph 1, wherein each of the haptic isolation means is measurable by the width or diameter of the isolation means and the length or height of the isolation means, and the length or height of at least one of the haptic isolation means is more than twice the width or diameter of the isolation means.

[0231] Section 17. The intraocular lens of Section 1, wherein the haptic isolation means are arranged in the shape of an arc, and the haptic isolation means include the most distal and most proximal haptic isolation means that function as the endpoints of the arc, the arc is measurable by a central angle or arc angle, and the central angle or arc angle is between 70 and 74 degrees.

[0232] Paragraph 18. The intraocular lens of paragraph 1, comprising at least one of an internal passage filler and an internal passage expander made of a composite material, wherein the composite material is configured to expand in response to receiving laser light directed toward the internal passage filler or internal passage expander, and the haptic isolation means is not made of the composite material.

[0233] Section 19. The haptic isolation means is the intraocular lens of Section 1, made of the same material as one or more walls of the haptic.

[0234] Paragraph 20. An intraocular lens comprising an optical portion, a haptic having a proximal end and a distal end coupled to the optical portion, wherein the haptic includes a haptic internal passage extending through at least a portion of the haptic, and a plurality of haptic isolation means arranged in an arc configuration within the haptic internal passage.

[0235] Section 21. The intraocular lens of Section 20, wherein the haptic internal passage is surrounded by the haptic radial lateral wall, the haptic radial medial wall, the haptic anterior wall, and the haptic posterior wall.

[0236] Section 22. The intraocular lens of Section 21, wherein the haptic isolation means is configured to restrict any radial movement of the radially outer wall of the haptic to 0-10 microns in response to a laser beam directed toward the haptic.

[0237] Paragraph 23. The haptic comprises at least one of an internal passage filler and an internal passage expander made of a composite material, wherein the composite material is configured to expand in response to receiving laser light directed toward the internal passage filler or internal passage expander, and the haptic isolation means is not made of a composite material, the intraocular lens of paragraph 22.

[0238] Section 24. The haptic separation means is the intraocular lens of Section 21, extending from the anterior haptic wall to the posterior haptic wall of the haptic.

[0239] Paragraph 25. An intraocular lens according to paragraph 21, wherein each of the haptic isolation means includes a side surface, and none of the sides of the haptic isolation means are in physical contact with the haptic radial medial wall or the haptic radial lateral wall.

[0240] Section 26. The intraocular lens of Section 21, wherein the haptic separation means is positioned radially closer to the haptic radial medial wall than to the haptic radial lateral wall.

[0241] Paragraph 27. An intraocular lens of paragraph 26, wherein at least one side of the haptic isolation means, closest to the haptic radial medial wall, is separated from the haptic radial medial wall by an internal isolation distance, and another side of the haptic isolation means, closest to the haptic radial lateral wall, is separated from the haptic radial lateral wall by an external isolation distance, the external isolation distance being 1.5 × ~ 3 × the internal isolation distance.

[0242] Section 28. The haptic isolation means is made of the same material as one or more walls of the haptic, as described in Section 20.

[0243] Paragraph 29. The intraocular lens of paragraph 20, wherein at least one of the haptic separation means is configured as a cylinder.

[0244] Paragraph 30. The intraocular lens of paragraph 29, having a substantially circular cross-section.

[0245] Paragraph 31. An intraocular lens according to paragraph 20, wherein at least one of the haptic separation means has a substantially rectangular cross-section, a substantially triangular cross-section, or a substantially elliptical cross-section.

[0246] Paragraph 32. The intraocular lens of paragraph 20, wherein multiple haptic isolation means are arranged as curved mid-exposure within the haptic internal passage.

[0247] Paragraph 33. The intraocular lens of paragraph 20, wherein multiple haptic isolation means are positioned at regular intervals along at least a portion of the haptic internal passage.

[0248] Section 34. The intraocular lens of Section 20, comprising 3 to 20 haptic separation means.

[0249] Paragraph 35. Each haptic isolation means comprises an isolation means front end, an isolation means rear end, and an isolation means section between the isolation means front end and the isolation means rear end, wherein the width or diameter of at least one of the isolation means front end and the isolation means rear end is greater than the isolation means section between the isolation means front end and the isolation means rear end, according to paragraph 20.

[0250] Paragraph 36. An intraocular lens of paragraph 20, wherein the width or diameter of at least one of the haptic isolation means remains constant along the length or height of the haptic isolation means.

[0251] Paragraph 37. The intraocular lens of paragraph 20, wherein each of the haptic isolation means is measurable by the width or diameter of the isolation means and the length or height of the isolation means, and the length or height of at least one of the haptic isolation means is more than twice the width or diameter of the isolation means.

[0252] Paragraph 38. The intraocular lens of paragraph 20, comprising a haptic isolation means including the most distal and most proximal haptic isolation means that serve as endpoints of the arc formation, wherein the arc formation is measurable by a central angle or arc angle, and the central angle or arc angle is between 70 and 74 degrees.

[0253] Paragraph 39. An intraocular lens comprising an optical portion, a haptic having a proximal end and a distal end coupled to the optical portion, the haptic including an internal haptic passage extending through at least a portion of the haptic, and one or more isolation blocks disposed within the internal haptic passage, at least one of which includes a non-circular cross-section.

[0254] Section 40. The intraocular lens of Section 39, wherein the haptic internal passage is surrounded by the haptic radial lateral wall, the haptic radial medial wall, the haptic anterior wall, and the haptic posterior wall.

[0255] Section 41. The intraocular lens of Section 40, wherein the isolation block is configured to restrict any radial movement of the haptic radial lateral wall to 0-10 microns in response to a laser beam directed toward the optic.

[0256] Section 42. One or more detached blocks extending from the anterior haptic wall to the posterior haptic wall of the intraocular lens as described in Section 40.

[0257] Paragraph 43. An intraocular lens according to paragraph 40, wherein each of one or more isolation blocks includes a lateral surface, and none of the lateral surfaces of one or more isolation blocks are in physical contact with the haptic radial medial wall or the haptic radial lateral wall.

[0258] Section 44. An intraocular lens as described in Section 40, wherein one or more isolation blocks are positioned radially closer to the haptic radial medial wall than to the haptic radial lateral wall.

[0259] Paragraph 45. An intraocular lens according to Paragraph 44, wherein at least one of the separation blocks, the side closest to the haptic radial medial wall, is separated from the haptic radial medial wall by a medial separation distance, and the other side of that separation block, the side closest to the haptic radial lateral wall, is separated from the haptic radial lateral wall by a lateral separation distance, the lateral separation distance being 1.5 × ~ 3 × greater than the medial separation distance.

[0260] Paragraph 46. An intraocular lens of paragraph 39, comprising at least one of an internal passage filler and an internal passage expander made of a composite material, wherein the composite material is configured to expand in response to receiving laser light directed toward the internal passage filler or internal passage expander, and one or more isolated blocks are not made of the composite material.

[0261] Paragraph 47. An intraocular lens as described in Paragraph 39, consisting of one or more isolation blocks made of the same material as one or more walls of the haptic.

[0262] Paragraph 48. An intraocular lens according to paragraph 39, wherein at least one of the separating blocks has a substantially oval cross-section.

[0263] Paragraph 49. An intraocular lens according to paragraph 39, wherein at least one of the separating blocks has a substantially rectangular cross-section.

[0264] Paragraph 50. An intraocular lens according to paragraph 39, wherein at least one of the separating blocks has a substantially elliptical cross-section.

[0265] Paragraph 51. The intraocular lens of paragraph 39, comprising a haptic comprising a plurality of isolation blocks arranged within an internal haptic passage, the isolation blocks being positioned at regular intervals along at least one section of the internal haptic passage.

[0266] Several embodiments have been described. Nevertheless, those skilled in the art will understand that various changes and modifications can be made to this disclosure without departing from the spirit and scope of the embodiments. Elements of systems, devices, apparatus and methods shown in any embodiment are illustrative for that particular embodiment and can be used in combination or otherwise in other embodiments within this disclosure. For example, the steps of any method depicted in the figures or described in this disclosure do not require a specific sequence or sequence shown or described in order to achieve the desired result. In addition, other step operations may be provided, or steps or operations may be excluded or omitted from the described method or process. Furthermore, any component or part of any apparatus or system described in the figures or described in this disclosure may be removed, excluded or omitted in order to achieve the desired result. In addition, certain components or parts of systems, devices or apparatus shown or described herein have been omitted for brevity and clarity.

[0267] Therefore, other embodiments are included within the scope of the claims set forth below, and this specification and / or drawings may be considered illustrative rather than restrictive.

[0268] Each of the individual variations or embodiments described and illustrated herein has individual components and features that may be readily separated from or readily combined with any of the features of any other variation or embodiment. Modifications may be made to adapt specific situations, materials, substance compositions, processes, process actions, or steps to the object, spirit, or scope of the invention.

[0269] The methods described herein may be performed in any logically possible order of the events described, or in the order in which the events are described. Furthermore, additional steps or operations may be provided or omitted to achieve the desired result.

[0270] Furthermore, if a range of values ​​is provided, all values ​​between the upper and lower limits of that range, as well as any other specified values ​​within that specified range or values ​​contained therein, are also included in the present invention. In addition, any optional feature of a described variant of the present invention may be expressed and claimed, either independently or in combination with any one or more of the features described herein. For example, a statement of a range of 1 to 5 should be considered to disclose partial ranges such as 1 to 3, 1 to 4, 2 to 4, 2 to 5, 3 to 5, as well as individual numerical values ​​within those ranges, such as 1.5, 2.5, etc., and any whole or partial increments between them.

[0271] All existing subject matter referenced herein (e.g., publications, patents, patent applications) is incorporated herein by reference in its entirety, except where such subject matter may conflict with the subject matter of the present invention (in which case the material present herein shall prevail). References are provided only with respect to disclosures prior to the filing date of this application. Nothing in this specification should be construed as acknowledging that the present invention is not entitled to a prior date by prior art.

[0272] References to singular items include the possibility of multiple identical items existing. More specifically, where used herein and in the accompanying claims, the singular forms “a,” “an,” “the said,” and “the” include the plural form unless the context clearly requires a different interpretation. Furthermore, it should be noted that claims may be drafted to exclude optional elements. Therefore, this statement is intended to serve as a prior basis for using exclusive terms such as “alone,” “only,” or for using “negative” limitations in connection with specifying claim elements. Unless otherwise specified, all technical and scientific terms used herein have the same meaning as generally understood by those skilled in the art to which the invention pertains.

[0273] A reference to the phrase "at least one of ~" means any combination of one or more of the items or components (or a list of items or components) that such a phrase modifies. For example, the phrase "at least one of A, B, and C" means (i) A, (ii) B, (iii) C, (iv) A, B, and C, (v) A and B, (vi) B and C, or (vii) A and C.

[0274] For understanding the scope of this disclosure, “comprising” and its derivatives are intended to be open-ended terms, as used herein, specifying the presence of a specified feature, element, component, group, integer and / or step, but not excluding the presence of other unspecified features, elements, components, group, integer and / or step. The same applies to similar words, such as “including,” “having,” and their derivatives. The terms “part,” “section,” “part,” “component,” “element,” or “component” may have a dual meaning when used in the singular, referring to one part or more parts. As used herein, the directional terms “forward, backward, upward, downward, vertical, horizontal, downward, transverse, lateral, and vertical” and other similar directional terms refer to their positions on a device or apparatus or their directions on a device or apparatus being translated or moved.

[0275] Finally, when used herein, terms of degree such as “substantially,” “about,” and “approximately” mean the stated value, or the stated value plus a reasonable amount of deviation from the stated value such that the final result does not change significantly or substantially (e.g., a maximum deviation of ±0.1%, ±1%, ±5%, or ±10%, such variation is appropriate). For example, “about 1.0 cm” can be interpreted as “1.0 cm” or “0.9 cm to 1.1 cm.” When terms of degree such as “about” or “approximately” are used to refer to a number or value that is part of a range, the terms can be used to modify both the minimum and maximum number or value.

[0276] This disclosure is not intended to be limited to any specific form described herein, but rather to encompass alternative forms, modifications, and equivalents of any variations or embodiments described herein. Furthermore, the scope of this disclosure includes all other variations or embodiments that may be obvious to those skilled in the art in view of this disclosure.

Claims

1. It is an intraocular lens, Optical parts including optical fluid chamber, A haptic having a proximal end coupled to the optical portion and a distal end, the haptic including an internal passage extending through at least a portion of the haptic and in fluid communication with the optical fluid chamber, and Multiple haptic isolation means arranged within the haptic internal passage Intraocular lenses, including those included.

2. The intraocular lens according to claim 1, wherein the haptic internal passage is surrounded by a haptic radially lateral wall, a haptic radially lateral wall, a haptic anterior wall, and a haptic posterior wall.

3. The intraocular lens according to claim 2, wherein the haptic isolation means is configured to restrict any radial movement of the radially outer wall of the haptic to 0 to 10 microns in response to a laser beam directed at the haptic.

4. The intraocular lens according to claim 2, wherein the haptic separation means extends from the anterior wall of the haptic to the posterior wall of the haptic.

5. The intraocular lens according to claim 2, wherein each of the haptic isolation means includes a side surface, and none of the side surfaces of the haptic isolation means physically contacts the haptic radially inner wall or the haptic radially outer wall.

6. The intraocular lens according to claim 2, wherein the haptic separation means is positioned radially closer to the radially inner wall of the haptic than to the radially outer wall of the haptic.

7. The intraocular lens according to claim 6, wherein at least one side of the haptic isolation means closest to the haptic radially medial wall is separated from the haptic radially medial wall by an internal isolation distance, and another side of the haptic isolation means closest to the haptic radially lateral wall is separated from the haptic radially lateral wall by an external isolation distance, the external isolation distance being 1.5 × to 3 × greater than the internal isolation distance.

8. The intraocular lens according to claim 1, wherein at least one of the haptic separation means is configured as a cylinder.

9. The intraocular lens according to claim 8, wherein the cylinder has a substantially circular cross-section.

10. The intraocular lens according to claim 1, wherein at least one of the haptic separation means has a substantially rectangular cross-section, a substantially triangular cross-section, or a substantially elliptical cross-section.

11. The intraocular lens according to claim 1, wherein the plurality of haptic separation means are arranged as a curved colonnade within the haptic internal passage.

12. The intraocular lens according to claim 1, wherein the plurality of haptic isolation means are arranged at regular intervals along at least one section of the haptic internal passage.

13. The intraocular lens according to claim 1, wherein the haptic includes 3 to 20 haptic separation means.

14. Each of the haptic isolation means includes an isolation means front end, an isolation means rear end, and an isolation means section between the isolation means front end and the isolation means rear end, wherein the width or diameter of at least one of the isolation means front end and the isolation means rear end is greater than the isolation means section between the isolation means front end and the isolation means rear end, as described in claim 1.

15. The intraocular lens according to claim 1, wherein the width or diameter of at least one of the haptic isolation means remains constant along the length or height of the haptic isolation means.

16. Each of the haptic isolation means is measurable by the width or diameter and the length or height of the isolation means, and the length or height of at least one of the haptic isolation means is more than twice the width or diameter of the isolation means, as described in claim 1.

17. The intraocular lens according to claim 1, wherein the haptic isolation means are arranged in the shape of an arc, and the haptic isolation means includes the most distal haptic isolation means and the most proximal haptic isolation means which act as the endpoints of the arc, and the arc is measurable by a central angle or arc angle, and the central angle or arc angle is between 70 degrees and 74 degrees.

18. The intraocular lens according to claim 1, wherein the haptic comprises at least one of an internal passage filler and an internal passage expander made of a composite material, the composite material is configured to expand in response to receiving laser light directed to the internal passage filler or the internal passage expander, and the haptic isolation means is not made of the composite material.

19. It is an intraocular lens, optical part, A haptic having a proximal end coupled to the optical portion and a distal end, and including an internal haptic passage extending through at least a portion of the haptic, and Multiple haptic isolation means arranged in an arc configuration within the haptic internal passage. An intraocular lens containing an intraocular lens.

20. It is an intraocular lens, optical part, A haptic having a proximal end coupled to the optical portion and a distal end, and including an internal haptic passage extending through at least a portion of the haptic, and One or more isolation blocks disposed within the haptic internal passage, wherein at least one of the one or more isolation blocks includes a non-circular cross-section. An intraocular lens containing an intraocular lens.

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