Stamp-type microneedles

Abstract

The present invention includes a main body, a pressing portion protruding from the upper end of the main body, a cartridge detachably engaged with the pressing portion, a base plate portion disposed between the cartridge and the pressing portion and forming a plurality of needle portions, and a cap detachably engaged with the main body 200 while housing the cartridge and the pressing portion, wherein the needles formed on the base plate portion are bent by the pressing force transmitted from the pressing portion and protrude from the upper part of the cartridge.

Description

Technical Field

[0001] The present invention relates to a stamp-type micro needle, and more particularly, to a stamp-type micro needle configured to be inserted into the skin of a user to simply and effectively deliver a high volume of active ingredients or drugs and to increase the skin absorption rate.

Background Art

[0002] Generally, as methods for delivering active ingredients or drugs into the body, there are methods of taking drugs, injecting drugs using injections, and absorbing drugs through the skin.

[0003] Among these methods, oral administration, that is, the method of taking drugs, can cause side effects on the central nervous system such as headache, drowsiness, dizziness, and nervous hypersensitivity, and serious digestive system side effects such as nausea, indigestion, diarrhea, peptic ulcer, gastrointestinal bleeding, and perforation, and its use is limited to short-term therapies only.

[0004] In addition, the method of injecting drugs using an injection directly injects the drug into the body by inserting a needle through the skin. Although the absorption is rapid, there is the trouble that it must be administered only by a professional (self-administration is difficult), and usually a needle with a diameter of several millimeters is used, so due to the pain during injection, the compliance of patients is not good.

[0005] In order to eliminate the above-mentioned side effects and drawbacks, the development of a drug delivery system by transdermal administration has been actively carried out.

[0006] Drugs usually absorbed through the skin are formulated in the form of solutions, creams, gels, etc. However, solutions, creams, and gels have problems in that it is difficult to adjust the dose due to the characteristics of the formulation, and they are sticky and stain clothes. In addition, many drugs are absorbed only in extremely small amounts and mostly evaporate.

[0007] Therefore, a method is used in which a patch containing the active ingredient or drug is applied to the skin to deliver the drug subcutaneously.

[0008] The patch method allows drugs to be absorbed through the skin, thus preventing side effects from oral medication, such as digestive problems or reactions to food. It also eliminates the pain and inconvenience associated with injections. Due to its ease of use, its adoption has been gradually increasing recently.

[0009] However, the patch method has the problem of low drug absorption through the skin. In other words, a major drawback of patches is that, due to the low absorption rate of drugs through the skin, the skin barrier function must be reduced. Drug absorption through patches is generally known to be around 20%, and to date, methods to improve absorption have been known, including chemical methods such as the use of skin absorption enhancers and prodrugs, and physical methods such as iontophoresis and electrophoresis.

[0010] However, even with these known methods, there are limits to improving drug absorption rates to a satisfactory level. Therefore, in order to expect therapeutic effects, it is impossible to avoid excessive drug use by considering absorption rates.

[0011] In particular, the type of skin absorption enhancer is determined by the design of the formulation to be used and the physicochemical properties of its constituent components. A certain level of concentration is required to be effective, but when skin absorption enhancers are added, it is not easy to prevent crystal formation over time, and there is a disadvantage that the adhesive properties such as adhesion and cohesiveness change to a state unsuitable for use.

[0012] Furthermore, technologies that utilize electricity have several drawbacks, including the fact that patches must contain batteries, electrodes, circuits, and other components, resulting in complex product configurations, large sizes, high prices, and the generation of large amounts of waste after use.

[0013] As a result, molten polymer microneedles carrying active ingredients or drugs have been developed to increase the skin absorption rate of active ingredients or drugs. However, they have drawbacks that make commercialization difficult until now, such as the small amount of drug that can be carried, the low skin penetration efficiency of the microneedles due to the strength limitations of the polymer, and the fact that the microneedles break if they are applied to an inclined surface rather than a vertical surface.

[0014] To solve the aforementioned problems, a method has been proposed in which multiple microneedles are formed and arranged on a thin, bioabsorbable metal plate containing components beneficial to the human body, and then adhered to the skin.

[0015] However, there is a problem in that it is difficult to form and arrange the aforementioned microneedles on a limited surface area of ​​a metal plate under conditions that maximize the delivery effect of the active ingredient or drug.

[0016] Furthermore, there is a problem in that the metal plate attached to the skin can easily detach due to the user's movements. Therefore, although an adhesive patch was devised to prevent the metal plate from detaching from the skin, this has the disadvantage of not creating a psychological aversion in the user because the adhesive patch and metal plate must be kept in close contact with the skin for a certain period of time.

[0017] Furthermore, in the case of microneedles, because they are made of very thin metal plates, they have the problem of easily breaking or bending when inserted into the skin.

[0018] Therefore, in order to solve the aforementioned problems, the applicant has developed the present invention, and a related prior art document is U.S. Patent Publication No. 2007-0293815, "Microprojection array application with sculptured microprojections for high drug loading." [Overview of the project] [Problems that the invention aims to solve]

[0019] The present invention was made to solve the aforementioned problems and aims to provide a stamp-type microneedle that is configured for use after the user easily bends the needle portion on a flat substrate portion.

[0020] Furthermore, the present invention aims to provide a stamp-type microneedle configured to allow the substrate portion on which the needle portion is arranged to be sterilized and packaged.

[0021] Furthermore, the present invention aims to provide a stamp-type microneedle configured to allow the user-operated applicator to be used semi-permanently.

[0022] Furthermore, the present invention aims to provide a stamp-type microneedle that can effectively deliver an active ingredient or drug subcutaneously to a user without requiring the substrate portion on which the needle portion is formed to adhere to the user's skin for a certain period of time, and is particularly capable of delivering high doses of active ingredients or drugs. [Means for solving the problem]

[0023] The present invention includes a pressing portion provided at the upper end of a main body, a cartridge detachably engaged with the pressing portion, and a base portion disposed between the cartridge and the pressing portion and forming a plurality of needle portions, wherein the needles formed on the base portion can be bent by the pressing force transmitted from the pressing portion and protrude from the upper part of the cartridge.

[0024] Furthermore, a protruding member can be formed on the upper surface of the pressing portion to press the area of ​​the substrate portion in which the needle portion is formed, and an engaging projection can be formed on the side surface of the pressing portion to engage with the cartridge.

[0025] Further, while having a form capable of accommodating the substrate portion, the cartridge is disposed so as to be linearly reciprocally movable above the pressing portion while being in the accommodated state, and a holder in which an opening through which the needle portion or the protruding member is inserted is formed, an elastic piece that can be elastically in contact with the upper surface of the main body while being connected to the longitudinal end of the holder and having a predetermined curvature, and an engaging portion that is connected to the end in the width direction of the holder and is fastened to the engaging protrusion formed on the side surface of the pressing portion can be included.

[0026] Further, an engaging hole into which the engaging protrusion formed on the side surface of the pressing portion is inserted can be formed in the engaging piece.

[0027] Further, the cartridge can further include a knob that is formed to protrude outside the width direction of the holder while being connected to the end of the engaging piece.

[0028] Further, a cap that is detachably engaged with the main body while accommodating the cartridge and the pressing portion is included, and a jig groove into which the cartridge is inserted and seated can be formed on the top surface of the cap.

[0029] Further, the jig groove includes a first groove into which the holder of the cartridge is inserted and held, and a second groove formed at a depth deeper than the depth of the first groove at a position where the first groove is formed, and the protruding member of the biasing portion is characterized in that it can be inserted into the second groove through the opening formed in the holder.

[0030] Further, the substrate portion can be inserted and seated in the inner space of the holder seated in the jig groove.

[0031] Further, among the regions of the substrate portion seated on the holder, the region where the needle portion is formed is inserted into the inner space of the cap and can be bent by receiving the pressing by the pressing portion that engages with the cartridge.

[0032] Furthermore, when the cartridge holder comes into contact with the user's skin, the distance between the holder and the upper end of the pressing portion decreases, and the needle portion of the substrate can be inserted into the user's skin through the opening formed in the holder. [Effects of the Invention]

[0033] The stamp-type microneedle according to the present invention allows consumers to easily bend the flat needle portion before use, thereby simplifying packaging volume and packaging work by allowing the substrate portion to be packaged in a flat form, and also enabling the provision of multiple substrate portions to consumers in a sterile state.

[0034] Furthermore, the stamp-type microneedle according to the present invention has a cap that blocks external contamination of the pressing part, cartridge, and substrate interposed between them, while also acting as a jig that makes the needle on the substrate bendable. This allows consumers to replace only the substrate and use the remaining components semi-permanently.

[0035] Furthermore, since the stamp-type microneedle according to the present invention controls the linear reciprocating movement of the pressing part using an elastic piece integrally connected to the cartridge, there is no need to separately provide an elastic means such as a spring, which reduces the number of parts and thus reduces manufacturing costs.

[0036] Furthermore, the stamp-type microneedle according to the present invention contains a bioabsorbable metal component that provides beneficial effects to the skin when inserted into the skin. Therefore, it can provide not only skin irritation and drug delivery effects, but also subcutaneous swelling effects and drug delivery enhancer functions.

[0037] Furthermore, the stamp-type microneedle according to the present invention also provides a structure that allows the microneedle inserted into the skin to be easily replaced according to the user, thereby preventing infection. [Brief explanation of the drawing]

[0038] [Figure 1] This is a perspective view of a stamp-type microneedle relating to one embodiment of the present invention.

[0039] [Figure 2] Figure 1 is an exploded perspective view of the stamp-type microneedle shown.

[0040] [Figure 3] This is a perspective view of the substrate portion according to one embodiment of the present invention.

[0041] [Figure 4] Figure 3 is a perspective view showing the substrate portion with the needle portion bent.

[0042] [Figure 5] This is a perspective view of the main body and pressing part according to one embodiment of the present invention.

[0043] [Figure 6] This is a perspective view of a cartridge according to one embodiment of the present invention.

[0044] [Figure 7] Figure 5 is a perspective view showing the cartridge attached to the pressing part of the main unit.

[0045] [Figure 8] This is a bottom perspective view showing the inside of the cap of one embodiment of the present invention.

[0046] [Figure 9] This is a bottom view of a cap according to an embodiment of the present invention.

[0047] [Figure 10] Figures 8 and 9 are perspective views showing the cartridge seated in the jig groove of the cap.

[0048] [Figure 11] Figure 10 is a bottom view of the cap.

[0049] [Figure 12] This is a bottom view showing the state in which the flat substrate shown in Figure 3 is placed inside the cartridge shown in Figures 10 and 11.

[0050] [Figure 13] Figure 12 is a cross-sectional view showing how the main body is inserted into the cap in order to bend the needle portion of the substrate shown. [Modes for carrying out the invention]

[0051] The advantages and features of the present invention, as well as methods for achieving them, will become clearer with reference to the embodiments described in detail later, along with the accompanying drawings.

[0052] However, the present invention is not limited to the embodiments disclosed below, but can be embodied in a variety of different forms, and these embodiments are merely provided to complete the disclosure of the present invention and to fully inform a person ordinary skill in the art to which the present invention pertains, and the present invention is defined only by the scope of the claims.

[0053] Next, a stamp-type microneedle according to one embodiment of the present invention will be described in detail with reference to Figures 1 to 13. In describing the present invention, if it is determined that a specific description of related known functions or configurations may obscure the gist of the present invention, such detailed description will be omitted.

[0054] Figure 1 is a perspective view of a stamp-type microneedle according to one embodiment of the present invention, Figure 2 is an exploded perspective view of the stamp-type microneedle shown in Figure 1, Figure 3 is a perspective view of the substrate portion according to one embodiment of the present invention, Figure 4 is a perspective view showing the needle portion bent on the substrate portion shown in Figure 3, Figure 5 is a perspective view of the main body and pressing portion according to one embodiment of the present invention, Figure 6 is a perspective view of the cartridge according to one embodiment of the present invention, Figure 7 is a perspective view showing the cartridge attached to the pressing portion of the main body shown in Figure 5, and Figure 8 is the present invention Figure 9 is a bottom perspective view showing the inside of the cap according to the embodiment of the present invention; Figure 10 is a perspective view showing the cartridge seated in the jig groove of the cap shown in Figures 8 and 9; Figure 11 is a bottom view of the cap shown in Figure 10; Figure 12 is a bottom view showing the state in which the flat plate-shaped substrate shown in Figure 3 is placed inside the cartridge shown in Figures 10 and 11; and Figure 13 is a cross-sectional view showing the main body being inserted into the inside of the cap in order to bend the needle portion of the substrate shown in Figure 12.

[0055] As shown in Figures 1 and 2, a stamp-type microneedle 100 according to one embodiment of the present invention may include a main body 200, a pressing portion 210 protruding from the upper end of the main body 200, a cartridge 300 detachably engaged with the pressing portion 210, a substrate portion 10 disposed between the cartridge 300 and the pressing portion 210 and forming a plurality of needle portions 20, and a cap 400 detachably engaged with the main body 200 while housing the cartridge 300 and the pressing portion 210.

[0056] The main body 200 refers to the component that the user grasps. Therefore, the main body 200 can have a size and shape that is easy to grasp with the hand.

[0057] Furthermore, as shown in Figure 5, a step 201 may be formed on the circumferential surface of the upper end of the main body 200. The step 201 is a portion that contacts the lower end of the cap 400, which will be described later, and acts as a stopper that limits the distance the main body 200 moves inside the cap 400.

[0058] The pressing portion 210 may have a flat area smaller than the flat area formed by the main body 200, and may protrude upward from the upper central part of the main body 200.

[0059] Furthermore, as shown in Figure 5, a protruding member 211 may be provided on the upper surface of the pressing portion 210 to press the area of ​​the substrate portion 10 in which the needle portion 20 is formed. Additionally, an engaging projection 212 that engages with the cartridge 300 can be formed on the side surface of the pressing portion 210.

[0060] The pressing portion 210, configured as described above, presses a portion of the surface area of ​​the substrate portion 10 (described later) to bend the needle 20 formed on the substrate portion 10 in a vertical direction, and also supports the cartridge 300 (described later) so that it can move back and forth in a straight line, thereby enabling insertion of the needle portion 20 into the user's skin.

[0061]

[0062] As shown in Figures 6 and 7, the cartridge 300 may include a holder 310 having a configuration that accommodates the substrate portion 10 (see Figure 3) and is arranged to move linearly back and forth above the pressing portion 210, with an opening 311 formed through which the needle portion 20 (see Figure 4) or the protruding member 210 is inserted; an elastic piece 320 having a predetermined curvature that is elastically contactable with the upper surface of the main body 200 while remaining connected to the longitudinal end of the holder 310; and an engaging piece 330 that is fastened with the engaging projection 212 formed on the side surface of the pressing portion 210 while remaining connected to the widthwise end of the holder 310.

[0063] The holder 310 may have a shape that surrounds the entire circumference of the upper end of the pressing portion 210, and when the engaging projection 212 of the pressing portion 210 is inserted into the engaging hole 311 formed in the engaging piece 330, it may be positioned above the upper surface of the pressing portion 210 at a predetermined distance.

[0064] The holder 310 may also be inserted into a jig groove 410 (see Figure 8) formed in the cap 400, which will be described later, and attached to the cap 400.

[0065] Furthermore, the opening 311 formed in the holder 310 can have a shape that corresponds to the protruding member 211 formed on the upper surface of the pressing portion 210.

[0066] For reference, in one embodiment of the present invention, two protruding members 211 are formed on the upper surface of the pressing portion 210, and correspondingly, two openings 311 are also formed in the holder 310.

[0067] The holder 310 configured as described above is movable toward the upper surface of the pressing portion 210 of the main body 200 by the force applied by the user when the user presses the pressing portion 210 toward the skin, and when the biasing force applied by the user to the pressing portion 210 is released, the holder can be returned to its original state by the elastic piece 320.

[0068] The elastic piece 320 may be integrally connected to the holder 310.

[0069] In other words, one longitudinal end of the elastic piece 320 can be integrally connected to the longitudinal end of the holder 310. The other longitudinal end of the elastic piece 320 can extend toward the upper surface of the main body 200.

[0070] Therefore, when the user presses the pressing portion 210 of the main body 200 toward the skin, the other longitudinal end of the elastic piece 320 can elastically bend while in contact with the upper surface of the main body 200. Conversely, when the biasing force of the user transmitted to the pressing portion 210 is released, the holder 310 can be positioned above the upper surface of the pressing portion 210 while returning to its original state by elastic restoring force.

[0071] The engaging piece 330 may also be connected integrally with the holder 310.

[0072] In other words, one longitudinal end of the locking piece 330 can be integrally connected to the widthwise end of the holder 310. The other longitudinal end of the engaging piece 330 can extend toward the upper surface of the main body 200.

[0073] On the other hand, the engagement hole 331 formed in the engagement piece 330 can be formed in the engagement piece 330 to be larger in size than the engagement projection 212 formed on the side surface of the pressing portion 210, so that the holder 310 can move.

[0074] In other words, it is preferable that the engagement hole 331 is formed in the engagement piece 330 with a space larger than the size of the engagement projection 212 so that when the pressing portion 210 presses against the skin, the holder 310 can move in a direction opposite to the pressing force. Therefore, as shown in Figure 7, even when the engagement projection 212 is inserted into and locked in the engagement hole 331, there is still empty space in the engagement hole 331.

[0075] Furthermore, the cartridge 300 may further include a knob 340 that is grasped by the user when separating the holder 310 on the pressing portion 210.

[0076] As shown in Figures 6 and 7, the knob 340 can be integrally connected to the locking piece 330. That is, one longitudinal end of the knob 340 can be integrally connected to the other longitudinal end of the engaging piece 330. The other longitudinal end of the knob 340 can extend outward in the width direction of the holder 310.

[0077] Therefore, the user can use the knob 340 to spread the engaging piece 330 outward in the width direction of the holder 310. This allows the engaging projection 212 of the pressing portion 210 to disengage from the engaging hole 313 of the engaging piece 330.

[0078] The cartridge 300 configured as described above stably supports the substrate portion 10, which will be described later, and acts as a guide so that the flat needle portion 20 can be easily bent vertically by receiving pressure from the protruding member 211 of the pressing portion 210.

[0079] Furthermore, when the user presses the pressing portion 210 of the cartridge 300 toward the skin, the bent needle portion 20 is exposed, allowing it to be inserted into the skin.

[0080]

[0081] The substrate portion 10 may have a flat plate shape, as shown in Figure 3.

[0082] Furthermore, multiple needle portions 20 can be formed on the substrate portion 10 in a patterned manner.

[0083] The patterned needles 20 may also be arranged in a flat shape, as shown in Figure 3.

[0084] Therefore, since the substrate portion 10 has an overall flat shape, it can be packaged in a sterile state and provided to consumers.

[0085] The sheet-like packaged substrate 10 is removed from its packaging and used, so as shown in Figures 2 and 13, it can be placed between the pressing portion 210 and the cartridge holder 310.

[0086] The needle portion 20 of the substrate portion 10, positioned between the pressing portion 210 and the holder 310, can be bent by the pressing force transmitted from the pressing portion 210, as shown in Figure 4, and protrude from the top of the cartridge 300. That is, the multiple needle portions 20 formed on the substrate portion 10 are pressed and bent by the protruding member 211 formed on the pressing portion 210, and then can pass through the opening formed in the holder 310 and be exposed to the outside.

[0087] For reference, the substrate portion 10 may be made of a metal containing at least one component from magnesium, calcium, zinc, and iron, which are used as bioabsorbable metals. Similarly, the needle portion 20 provided on the substrate portion 10 may also be made of a metal containing at least one component from magnesium, calcium, zinc, and iron, which are used as bioabsorbable metals.

[0088] Furthermore, there have been cases of bioabsorbable metals being commercialized both domestically and internationally, with magnesium-based alloys being produced for use in orthopedic implants. For orthopedic implants, the focus is on maximizing the rate of degradation in the body and improving corrosion resistance to ensure safe fracture fixation.

[0089] However, unlike bioabsorbable metals applied for orthopedic surgery, the bioabsorbable metal forming the substrate portion 10 and needle portion 20 according to one embodiment of the present invention may be subject to a mechanism that accelerates the rate of decomposition in the body, enabling subcutaneous drug release and mineral supply.

[0090] For example, magnesium, calcium, and zinc, which are used as bioabsorbable metals, can have a mechanism to decompose by reacting with water in the body and releasing hydrogen gas. Therefore, when the needle portion 20 formed on the substrate portion 10 is inserted into the skin, it releases ions and decomposition products subcutaneously, and the hydrogen gas, one of the by-products, can provide a swelling effect subcutaneously, leading to a wrinkle-improving effect.

[0091] In addition, ZnO and MgCl, by-products generated when magnesium and zinc, components of bioabsorbable metals, are inserted into the body, can remain subcutaneously and act as drug delivery enhancers, improving the subcutaneous absorption of active ingredients or drugs. Therefore, the substrate portion 10 and needle portion 20, formed from bioabsorbable metals, also have the function of effectively delivering active ingredients or drugs supported on themselves, or active ingredients or drugs transmitted from the outside, to the subcutaneous tissue.

[0092] For reference, stainless steel, used as microneedles, has higher strength, elastic modulus, and melting point compared to magnesium. Therefore, mechanically processing needles into a flat shape requires more tool wear and energy, resulting in higher manufacturing costs. Even with non-contact laser processing, the high melting point requires more energy, generates heat, and creates burrs on the processed surface, necessitating a process and expense to remove these burrs. In contrast, magnesium alloys have a tensile strength of approximately 100-400 MPa, sufficient to penetrate skin, and an elastic modulus of approximately 40-60 GPa, meaning the force required for consumers to bend them is significantly less than that of stainless steel. Magnesium has a melting point of approximately 650-750°C, allowing for processing with relatively little energy. Furthermore, it produces a cleaner surface than stainless steel after processing, offering the advantage of being usable without further processing. Furthermore, if the needle inserted into the skin breaks or remains embedded, stainless steel may cause inflammation or migration within the skin, potentially inducing pain, necrosis, etc. In contrast, magnesium alloy has the advantage of safely decomposing and disappearing.

[0093] As shown in Figures 1 and 2, the cap 400 can be detachably engaged with the upper end of the main body 200.

[0094] Furthermore, as shown in Figures 8 and 9, the cap 400 has an internal space in which the pressing portion 210 and the cartridge 300 can be accommodated.

[0095] A jig groove 410 can be formed on the top surface of the cap 400, into which the cartridge 300 is inserted and seated.

[0096]

[0097] The jig groove 410 may include a first groove 420 into which the holder 310 of the cartridge 300 is inserted and seated, and a second groove 430 formed at the same location as the first groove 420 and deeper than the depth of the first groove 420.

[0098] The first groove 420 may have a configuration that corresponds to the holder 310 of the cartridge 300.

[0099] The second groove 430 may have a configuration corresponding to the protruding member 211 of the pressing portion 210.

[0100] Therefore, as shown in Figures 10 and 11, the user can insert the cartridge 300 into the inner space of the cap 400 and seat it in the jig groove 410.

[0101] As shown in Figures 10 and 11, the reason for inserting and fixing the cartridge 300 into the inner space of the cap 400 is to provide a space on which the flat base plate portion 10 can be seated, and then to press and bend the needle portion 20 formed on the base plate portion 10.

[0102] In other words, as shown in Figure 12, the substrate portion 10 can be inserted into and seated in the inner space of the holder 310 which is seated in the jig groove 410.

[0103] The area of ​​the substrate portion 10 seated on the holder 310 in which the needle portion 20 is formed can be pressed and bent by the pressing portion 210, which is inserted into the inner space of the cap 400 and engages with the cartridge 300, as shown in Figure 13.

[0104] Incidentally, as shown in Figure 13, the pressing part 210 can be inserted into the inner space of the overturned cap 400 in the direction of arrow A, and can press the needle part 20 of the base plate 10 seated on the holder 310. In other words, after the protruding member 211 of the pressing part 210 presses the needle part 20 seated on the holder 310, it can be inserted into the second groove 430 of the jig groove 410.

[0105] As a result, the needle portion 20 of the flat substrate portion 10 can be bent vertically by the protruding member 211. At the same time, the engaging projection 212 formed on the side surface of the pressing portion 210 can be inserted into the engaging hole 331 formed in the engaging portion 330 of the cartridge 300.

[0106] In this state, when the force transmitted to the pressing portion 210 is released, the main body 200 and the pressing portion 210 can move in the direction of arrow B shown in Figure 13 by the elastic piece 320 of the cartridge 300.

[0107] When the above-described state is reached, the needle portion 20 positioned between the pressing portion 210 and the holder 310 can be transformed into a form that can be inserted into the skin, as shown in Figure 4.

[0108] The user can remove the cap 400 from the main body 200 in order to insert the needle portion 20 into the skin. Then, when the main body 200 is pushed toward the skin with the holder 310 for the cartridge 300 in contact with the skin, the distance between the upper end of the pressing portion 210 and the holder 310 decreases. At this time, the base portion 10 is pressed by the pressing portion 210 and moves in the direction in which the skin is positioned, and the bent needle portion 20 can be inserted into the skin by passing through the opening 311 formed in the holder 310.

[0109] For reference, a peripheral groove 401 may be formed on the inner circumferential surface of the cap 400, as shown in Figure 13, and a projection 202 (see Figure 5) formed on the upper end edge of the main body 200 can be inserted into the peripheral groove 401.

[0110]

[0111] The stamp-type microneedle 100 having the above configuration allows consumers to easily bend the sheet-like needle portion 20 before use, thus simplifying packaging volume and packaging work by packaging the substrate portion 10 in a sheet form, and also allowing multiple substrate portions 10 to be provided to consumers in a sterile state.

[0112] Furthermore, the stamp-type micro-needle 100 according to the present invention has a cap 400 that blocks external contamination of the pressing portion 210 and cartridge 300, as well as the substrate portion 10 interposed between them, while simultaneously acting as a jig that makes the needle portion 20 of the substrate portion 10 bendable. This allows consumers to replace only the substrate portion 10, while the remaining components can be used semi-permanently.

[0113] Furthermore, the stamp-type micro-needle 100 according to the present invention controls the linear reciprocating movement of the pressing portion 210 using an elastic piece 320 integrally connected with the cartridge 300. Therefore, there is no need to separately provide an elastic means such as a spring, which reduces the number of parts and thereby lowers manufacturing costs.

[0114] Furthermore, many people have needle phobia, but the stamp-type microneedle according to one embodiment of the present invention does not cause fear because the needle portion 20 is hidden, and can be used appropriately while controlling the biasing force to an appropriate level, even though the user feels pain after it touches the skin.

[0115] Furthermore, the wall partitioning the opening 311 of the cartridge 300 supports the needle portion 20 so that it does not break when it penetrates the skin. Therefore, when used in combination with an active ingredient, after the needle portion 20 has penetrated, the protruding member applies pressure, which puts pressure on the active ingredient between the needles, dramatically increasing the skin absorption rate.

[0116] Although specific embodiments of the present invention have been described above, it goes without saying that various modifications are possible without departing from the scope of the present invention.

[0117] Therefore, the scope of the present invention should not be limited to the embodiments described above, but should be defined not only by the claims described below, but also by claims equivalent to those described above. [Industrial applicability]

[0118] This invention can be sold and used in a variety of industrial fields, such as the medical field and the dermatological beauty field.

Claims

1. A pressing part is provided at the upper end of the main body, A cartridge that is detachably engaged with the pressing portion, It includes a substrate portion disposed between the cartridge and the pressing portion, which forms a plurality of needle portions, A stamp-type microneedle characterized in that the needle formed on the substrate portion is bent by the pressing force transmitted from the pressing portion and protrudes from the top of the cartridge.

2. A protruding member is formed on the upper surface of the pressing portion, which presses the area of ​​the substrate portion in which the needle portion is formed. The stamp-type microneedle according to claim 1, characterized in that an engaging projection is formed on the side surface of the pressing portion, which engages with the cartridge.

3. The aforementioned cartridge is A holder having a configuration that can accommodate the substrate portion, positioned so as to be able to move linearly back and forth above the pressing portion, and having an opening formed through which the needle portion or the protruding member is inserted, An elastic piece having a predetermined curvature is provided, which remains connected to the longitudinal end of the holder and is capable of elastically contacting the upper surface of the main body. The stamp-type microneedle according to claim 2, characterized in that it includes an engaging portion which remains connected to the widthwise end of the holder and fastens with the engaging projection formed on the side surface of the pressing portion.

4. The stamp-type microneedle according to claim 3, characterized in that the engaging piece has an engaging hole into which the engaging projection formed on the side surface of the pressing portion can be inserted.

5. The aforementioned cartridge is The stamp-type microneedle according to claim 3, further comprising a knob that remains connected to the end of the engaging piece and protrudes outward in the width direction of the holder.

6. The cap includes the cartridge and the pressing part, and is detachably engaged with the main body while the cartridge and pressing part are housed within it. The stamp-type microneedle according to claim 3, characterized in that a jig groove is formed on the top surface of the cap into which the cartridge is inserted and seated.

7. The jig groove is The first groove into which the holder of the cartridge is inserted and seated, The device comprises a second groove formed at the same location as the first groove, which is deeper than the depth of the first groove, The stamp-type microneedle according to claim 6, characterized in that the protruding member of the pressing portion can be inserted into the second groove through the opening formed in the holder.

8. The stamp-type microneedle according to claim 7, characterized in that the substrate portion is inserted into and seated in the inner space of the holder seated in the jig groove.

9. The stamp-type microneedle according to claim 8, characterized in that, of the region of the substrate portion seated on the holder, the region in which the needle portion is formed is inserted into the inner space of the cap and pressed and bent by the pressing portion which engages with the cartridge.

10. The stamp-type microneedle according to claim 3, characterized in that when the holder of the cartridge comes into contact with the user's skin, the distance between the holder and the upper end of the pressing portion decreases, and the needle of the substrate portion passes through the opening formed in the holder and is inserted into the user's skin.

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