Compounds and compositions as CBP / P300 decomposing agents and their use

Abstract

Compounds of formula I, and their pharmaceutically acceptable salts, solvates, or stereoisomers, as well as their uses (e.g., use for the degradation of certain proteins such as CBP / p300 protein), are described herein.

Description

[Technical Field]

[0001] Related applications This application claims the benefits and priority of U.S. Provisional Patent Application No. 63 / 505,201, filed on 31 May 2023, and U.S. Provisional Patent Application No. 63 / 519,002, filed on 11 August 2023, the contents of each of these applications being incorporated herein by reference in their entirety. [Background technology]

[0002] Proteolytically targeted chimeric (PROTAC) molecules are heterobifunctional compounds that simultaneously bind to a target protein and an E3 ligase complex, initiating a process that leads to ubiquitin transfer and ultimately proteasomal degradation of the target protein. By catalyzing the formation of a triple complex involving the E3 ligase receptor, the target protein, and a small molecule, PROTACs can result in enhanced substrate specificity. There is a continuing need for selective PROTAC molecules to treat and / or prevent cancers and other diseases that respond to inhibition or degradation of CBP / p300 proteins. P300-selective degraders exhibit potent selectivity for p300 over CBP, showing time-dependent loss of p300, enhancer acetylation, and transcriptional production in cancer cells both in vitro and in vivo, with limited toxicity to untransformed cells. Enhanced dependence on p300 is observed across numerous cancer lines. [Overview of the Initiative]

[0003] In certain embodiments, this disclosure relates to compounds of formula I: TLC(I), The formula provides a pharmaceutically acceptable salt, solvate, or stereoisomer thereof, wherein, C is the expression in equation I-1', TIFF2026521988000001.tif35128T is, i) Equation I-3-i TIFF2026521988000002.tif23128ii) Formula I-3-ii TIFF2026521988000003.tif25128iii) Formula I-3-iii TIFF2026521988000004.tif28128iv) Formula I-3-iv TIFF2026521988000005.tif21128v) Formula I-3-v TIFF2026521988000006.tif21128 or vi) Equation I-3-vi The filename is TIFF2026521988000007.tif18128. L is the expression in equation I-2'', Each of the variables in formulas I-1', I-2', I-3-i, I-3-ii, I-3-iii, I-3-iv, I-3-v, and I-3-vi is described, embodied, and illustrated herein.

[0004] In certain embodiments, the Disclosure provides a pharmaceutical composition comprising a compound disclosed herein and a pharmaceutically acceptable excipient.

[0005] In certain embodiments, the Disclosure provides a method for degrading proteins in a subject or biological sample, comprising administering a compound disclosed herein to the subject or contacting a biological sample with a compound disclosed herein.

[0006] In certain embodiments, this disclosure provides the use of compounds disclosed herein in the manufacture of pharmaceuticals for the degradation of proteins in a subject or biological sample.

[0007] In certain embodiments, the Disclosure provides compounds disclosed herein for use in the degradation of proteins in a subject or biological sample. [Modes for carrying out the invention]

[0008] The present disclosure relates to compounds that exhibit activity in the degradation of a specific protein (e.g., p300 / CBP), and pharmaceutical compositions containing such compounds. The compounds of the present disclosure

[0009] In certain embodiments, the present disclosure provides compounds of formula I: T-L-C(I), and pharmaceutically acceptable salts, solvates, or stereoisomers thereof, wherein C is of the formula I-1’, TIFF20265219880 For the formula in 000009.tif38128, TIFF2026521988000010.tif8128 indicates attachment to L, B B4 is CR B1 or N, B 3 is CR B3 or N, B 4 is CR B4 or N, B 5 is CR B5 or N, B 6 is C or N, R B1 、R B3 、R B4 、and R B5 are independently oxo, hydrogen, halogen, -CN, -NO2, -OH, -NH2, C 1-6 alkyl, C 1-6 alkoxy, C 1-6 alkylamino, C 3-4 carbocyclic, or 3- to 5-membered heterocyclic, and alkyl, alkoxy, alkylamino, carbocyclic, or heterocyclic may be substituted with one or more R u and X is absent, O, S, or NR X and R X is hydrogen, C 1-3 alkyl, C 3-4Carbocyclyl, or 3-4 membered heterocyclyl, R D1 is hydrogen, deuterium, or C 1-6 It is alkyl, Each R D These are, independently, halogen, -CN, -NO2, -OH, -NH2, C 1-6 Alkyl, C 1-6 Alkoxy, C 1-6 Alkylamino, C 3-4 Carbocyclyl, or 3-4 membered heterocyclyl, wherein alkyl, alkoxy, alkylamino, carbocyclyl, or heterocyclyl is one or more R u It may also be replaced with d is an integer between 0 and 6, as long as the valence allows. q is an integer between 0 and 2. T is i) Formula I-3-i TIFF2026521988000011.tif25128 (in the formula, E 1 teeth, TIFF2026521988000012.tif8128,CR E1 , or N, E 2 teeth, TIFF2026521988000013.tif8128,CR E2 , or N, E 3 teeth, TIFF2026521988000014.tif8128,CR E3 , or N, TIFF2026521988000015.tif8128 shows adhesion to L, R E1 , R E2 , R E3 , and R E4 These are independently hydrogen, halogen, -CN, -NO2, -OH, -NH2, C 1-6 Alkyl, C 1-6 Alkoxy, C 1-6 Alkylamino, C 2-6 Alkenil, C 2-6Alkinyl, C 3-12 Carbocyclyl, 3-12 member heterocyclyl, C 6-10 Aryl, 5-10 member heteroaryl, -SR b -S(=O)R a -S(=O)2R a -S(=O)2OR b -S(=O)2NR c R d , -NR c S(=O)2R a , -NR c S(=O)R a , -NR c S(=O)2OR b , -NR c S(=O)2NR c R d , -NR b C(=O)NR c R d , -NR b C(=O)R a , -NR b C(=O)OR b -OS(=O)2R a -OS(=O)2OR b -OS(=O)2NR c R d -OC(=O)R a , -OC(=O)OR b -OC(=O)NR c R d -C(=O)R a , -C(=O)OR b , or -C(=O)NR c R d Alkyl, alkoxy, alkylamino, alkenyl, alkynyl, carbocykyl, heterocyclyl, aryl, or heteroaryl is one or more R u It may also be replaced with F 1 is C or N, F 2 , NR F2’ or CR F2 And, R F2’ is hydrogen, C 1-6 Alkyl, C 2-6Alkenyl, C 2-6 Alkynyl, C 3-12 Carbocyclic, 3 - 12 - member heterocyclic, C 6-10 Aryl, 5 - 10 - member heteroaryl, -S(=O)2R a , -S(=O)2OR b , -S(=O)2NR c R d , -C(=O)R a , -C(=O)OR b , or -C(=O)NR c R d where alkyl, alkenyl, alkynyl, carbocyclic, heterocyclic, aryl, or heteroaryl may be substituted with one or more R u and R F2 is hydrogen, halogen, -CN, -NO2, -OH, -NH2, C 1-6 alkyl, C 1-6 alkoxy, C 1-6 alkylamino, C 2-6 alkenyl, C 2-6 alkynyl, C 3-12 carbocyclic, 3 - 12 - member heterocyclic, C 6-10 aryl, 5 - 10 - member heteroaryl, -SR b , -S(=O)R a , -S(=O)2R a , -S(=O)2OR b , -S(=O)2NR c R d , -NR c S(=O)2R a , -NR c S(=O)R a , -NR c S(=O)2OR b ]>, -NR c S(=O)2NR c R d , -NR b C(=O)NR c R d , -NR b C(=O)R a , -NR b C(=O)OR b , -OS(=O)2R a-OS(=O)2OR b -OS(=O)2NR c R d -OC(=O)R a , -OC(=O)OR b -OC(=O)NR c R d -C(=O)R a , -C(=O)OR b , or -C(=O)NR c R d Alkyl, alkoxy, alkylamino, alkenyl, alkynyl, carbocykyl, heterocyclyl, aryl, or heteroaryl is one or more R u It may also be replaced with F 3 CR F3 , N, or NR F3’ And, R F3 These are hydrogen, halogen, -CN, -NO2, -OH, -NH2, C 1-6 Alkyl, C 1-6 Alkoxy, C 1-6 Alkylamino, C 2-6 Alkenil, C 2-6 Alkinyl, C 3-12 Carbocyclyl, 3-12 member heterocyclyl, C 6-10 Aryl, 5-10 member heteroaryl, -SR b -S(=O)R a -S(=O)2R a -S(=O)2OR b -S(=O)2NR c R d , -NR c S(=O)2R a , -NR c S(=O)R a , -NR c S(=O)2OR b , -NR c S(=O)2NR c R d , -NR b C(=O)NR c R d , -NR b C(=O)R a , -NR bC(=O)OR b -OS(=O)2R a -OS(=O)2OR b -OS(=O)2NR c R d -OC(=O)R a , -OC(=O)OR b -OC(=O)NR c R d -C(=O)R a , -C(=O)OR b , or -C(=O)NR c R d Alkyl, alkoxy, alkylamino, alkenyl, alkynyl, carbocykyl, heterocyclyl, aryl, or heteroaryl is one or more R u It may also be replaced with R F3’ is hydrogen, C 1-6 Alkyl, C 2-6 Alkenil, C 2-6 Alkinyl, C 3-12 Carbocyclyl, 3-12 member heterocyclyl, C 6-10 Aryl, 5-10 member heteroaryl, -S(=O)2R a -S(=O)2OR b -S(=O)2NR c R d -C(=O)R a , -C(=O)OR b , or -C(=O)NR c R d Alkyl, alkenyl, alkynyl, carbocykyl, heterocyclyl, aryl, or heteroaryl is one or more R u It may also be replaced with R F4 is -C(=O)NR 3a R 3b , or one or more R u It is a 5-6 member heteroaryl which may be substituted with R 3a and R 3b These are, independently, hydrogen and C 1-6 Alkyl, C 2-6 Alkenil, C 2-6 Alkinyl, C3-12 Carbocyclyl, 3-12 member heterocyclyl, C 6-10 Aryl, 5-10 member heteroaryl, -S(=O)2R a -S(=O)2OR b -S(=O)2NR c R d -C(=O)R a , -C(=O)OR b , or -C(=O)NR c R d Alkyl, alkenyl, alkynyl, carbocykyl, heterocyclyl, aryl, or heteroaryl is one or more R u It may be replaced with, or R 3a and R 3b These, together with the nitrogen atoms to which they are bonded, form a 3-12 membered heterocycle or a 5-10 membered heteroaryl, and the heterocycle or heteroaryl contains one or more R u (May be replaced by) ii) Formula I-3-ii TIFF2026521988000016.tif28128 (in the formula, G 1 teeth, TIFF2026521988000017.tif8128, N, or CR G1 And, G 2 teeth, TIFF2026521988000018.tif8128, N, or CR G2 And, G 3 teeth, TIFF2026521988000019.tif8128, N, or CR G3 And, TIFF2026521988000020.tif8128 shows adhesion to L, R G1 , R G2 , R G3 , and R G4 These are independently hydrogen, halogen, -CN, -NO2, -OH, -NH2, C 1-6 Alkyl, C1-6 Alkoxy, C 1-6 Alkylamino, C 2-6 Alkenil, C 2-6 Alkinyl, C 3-12 Carbocyclyl, 3-12 member heterocyclyl, C 6-10 Aryl, 5-10 member heteroaryl, -SR b -S(=O)R a -S(=O)2R a -S(=O)2OR b -S(=O)2NR c R d , -NR c S(=O)2R a , -NR c S(=O)R a , -NR c S(=O)2OR b , -NR c S(=O)2NR c R d , -NR b C(=O)NR c R d , -NR b C(=O)R a , -NR b C(=O)OR b -OS(=O)2R a -OS(=O)2OR b -OS(=O)2NR c R d -OC(=O)R a , -OC(=O)OR b -OC(=O)NR c R d -C(=O)R a , -C(=O)OR b , or -C(=O)NR c R d Alkyl, alkoxy, alkylamino, alkenyl, alkynyl, carbocykyl, heterocyclyl, aryl, or heteroaryl is one or more R u It may also be replaced with H 1 C(R H1 )2, NR H1’ , or O, H 2C(R H2 )2, NR H2’ , or O, R H1 and R H2 Each occurrence is independently of hydrogen, halogen, -CN, -NO2, -OH, -NH2, C 1-6 Alkyl, C 1-6 Alkoxy, C 1-6 Alkylamino, C 2-6 Alkenil, C 2-6 Alkinyl, C 3-12 Carbocyclyl, 3-12 member heterocyclyl, C 6-10 The aryl or 5-10 membered heteroaryl is an alkyl, alkoxy, alkylamino, alkenyl, alkynyl, carbocykrill, heterocyclyl, aryl, or heteroaryl, which has one or more R u It may be replaced with, or Two R's H1 or two R's H2 Together with the carbon atoms to which they are bonded, C 3-6 It forms a carbocyclic ring or a 3- to 6-membered heterocyclic ring, and the carbocyclic ring or heterocyclic ring has one or more R u It may also be replaced with R H1’ and R H2’ Hydrogen and C are independent of each other. 1-6 Alkyl, C 3-6 Carbocyclyl, 3-6 member heterocyclyl, -S(=O)2R a -S(=O)2OR b -S(=O)2NR c R d -C(=O)R a , -C(=O)OR b , or -C(=O)NR c R d And alkyl, carbocyryl, or heterocyclyl is one or more R u (May be replaced by) iii) Equation I-3-iii TIFF2026521988000021.tif28128 (in the formula, TIFF2026521988000022.tif8128 shows adhesion to L, I 1 C(R I1 )2, NR I1’ , or O, I 2 C(R I2 )2, NR I2’ , or O, R I1 and R I2 Each occurrence is independently of hydrogen, halogen, -CN, -NO2, -OH, -NH2, C 1-6 Alkyl, C 1-6 Alkoxy, C 1-6 Alkylamino, C 2-6 Alkenil, C 2-6 Alkinyl, C 3-12 Carbocyclyl, 3-12 member heterocyclyl, C 6-10 The aryl or 5-10 membered heteroaryl is an alkyl, alkoxy, alkylamino, alkenyl, alkynyl, carbocykrill, heterocyclyl, aryl, or heteroaryl, which has one or more R u It may be replaced with, or Two R's I1 or two R's I2 Together with the carbon atoms to which they are bonded, C 3-6 It forms a carbocyclic ring or a 3- to 6-membered heterocyclic ring, and the carbocyclic ring or heterocyclic ring has one or more R u It may also be replaced with R I1’ and R I2’ Hydrogen and C are independent of each other. 1-6 Alkyl, C 3-6 Carbocyclyl, 3-6 member heterocyclyl, -S(=O)2R a -S(=O)2OR b -S(=O)2NR c R d -C(=O)R a , -C(=O)OR b , or -C(=O)NR c R d And alkyl, carbocyryl, or heterocyclyl is one or more R u It may also be replaced with Each R IThese are independently oxo, halogen, -CN, -NO2, -OH, -NH2, C 1-6 Alkyl, C 1-6 Alkoxy, C 1-6 Alkylamino, C 2-6 Alkenil, C 2-6 Alkinyl, C 3-12 Carbocyclyl, 3-12 member heterocyclyl, C 6-10 Aryl, 5-10 member heteroaryl, -SR b -S(=O)R a -S(=O)2R a -S(=O)2OR b -S(=O)2NR c R d , -NR c S(=O)2R a , -NR c S(=O)R a , -NR c S(=O)2OR b , -NR c S(=O)2NR c R d , -NR b C(=O)NR c R d , -NR b C(=O)R a , -NR b C(=O)OR b -OS(=O)2R a -OS(=O)2OR b -OS(=O)2NR c R d -OC(=O)R a , -OC(=O)OR b -OC(=O)NR c R d -C(=O)R a , -C(=O)OR b , or -C(=O)NR c R d Alkyl, alkoxy, alkylamino, alkenyl, alkynyl, carbocykyl, heterocyclyl, aryl, or heteroaryl is one or more R u It may also be replaced with i is an integer selected from 0 to 4. J 1 is N or CR J1 And, J 2 is N or CR J2 And, R J1 , R J2 , and R J3 These are independently hydrogen, halogen, -CN, -NO2, -OH, -NH2, C 1-6 Alkyl, C 1-6 Alkoxy, C 1-6 Alkylamino, C 2-6 Alkenil, C 2-6 Alkinyl, C 3-12 Carbocyclyl, 3-12 member heterocyclyl, C 6-10 Aryl, 5-10 member heteroaryl, -SR b -S(=O)R a -S(=O)2R a -S(=O)2OR b -S(=O)2NR c R d , -NR c S(=O)2R a , -NR c S(=O)R a , -NR c S(=O)2OR b , -NR c S(=O)2NR c R d , -NR b C(=O)NR c R d , -NR b C(=O)R a , -NR b C(=O)OR b -OS(=O)2R a -OS(=O)2OR b -OS(=O)2NR c R d -OC(=O)R a , -OC(=O)OR b -OC(=O)NR c R d -C(=O)R a , -C(=O)OR b , or -C(=O)NR c Rd Alkyl, alkoxy, alkylamino, alkenyl, alkynyl, carbocykyl, heterocyclyl, aryl, or heteroaryl is one or more R u (May be replaced by) iv) Equation I-3-iv TIFF2026521988000023.tif21128 (in the formula, M 1 is N or C, M 2 teeth, TIFF2026521988000024.tif10128, N, or CR M2 And, M 3 teeth, TIFF2026521988000025.tif10128, N, or CR M3 And, M 4 teeth, TIFF2026521988000026.tif10128, N, or CR M4 And, During the ceremony, TIFF2026521988000027.tif8128 shows adhesion to L, M 1 M 2 M 3 , and M 4 At least one of them is N or The filename is TIFF2026521988000028.tif8128. R M2 , R M3 , and R M4 These are independently hydrogen, halogen, -CN, -NO2, -OH, -NH2, C 1-6 Alkyl, C 1-6 Alkoxy, C 1-6 Alkylamino, C 2-6 Alkenil, C 2-6 Alkinyl, C 3-12 Carbocyclyl, 3-12 member heterocyclyl, C 6-10 Aryl, 5-10 member heteroaryl, -SR b -S(=O)R a-S(=O)2R a -S(=O)2OR b -S(=O)2NR c R d , -NR c S(=O)2R a , -NR c S(=O)R a , -NR c S(=O)2OR b , -NR c S(=O)2NR c R d , -NR b C(=O)NR c R d , -NR b C(=O)R a , -NR b C(=O)OR b -OS(=O)2R a -OS(=O)2OR b -OS(=O)2NR c R d -OC(=O)R a , -OC(=O)OR b -OC(=O)NR c R d -C(=O)R a , -C(=O)OR b , or -C(=O)NR c R d Alkyl, alkoxy, alkylamino, alkenyl, alkynyl, carbocykyl, heterocyclyl, aryl, or heteroaryl is one or more R u It may also be replaced with R K’ is hydrogen, C 1-6 Alkyl, C 2-6 Alkenil, C 2-6 Alkinyl, C 3-12 Carbocyclyl, 3-12 member heterocyclyl, C 6-10 Aryl, 5-10 member heteroaryl, -S(=O)2R a -S(=O)2OR b -S(=O)2NR c R d -C(=O)R a , -C(=O)OR b, or -C(=O)NR c R d Alkyl, alkenyl, alkynyl, carbocykyl, heterocyclyl, aryl, or heteroaryl is one or more R u It may also be replaced with K 1 is -C(=O)- or -C(R K1 )2-, Each R K1 These are independently hydrogen, halogen, -CN, -NO2, -OH, -NH2, C 1-6 Alkyl, C 1-6 Alkoxy, C 1-6 Alkylamino, C 2-6 Alkenil, C 2-6 Alkinyl, C 3-12 Carbocyclyl, 3-12 member heterocyclyl, C 6-10 The aryl or 5-10 membered heteroaryl is an alkyl, alkoxy, alkylamino, alkenyl, alkynyl, carbocykrill, heterocyclyl, aryl, or heteroaryl, which has one or more R u It may also be replaced with Each R K These are independently oxo, hydrogen, halogen, -CN, -NO2, -OH, -NH2, C 1-6 Alkyl, C 1-6 Alkoxy, C 1-6 Alkylamino, C 2-6 Alkenil, C 2-6 Alkinyl, C 3-12 Carbocyclyl, 3-12 member heterocyclyl, C 6-10 Aryl, 5-10 member heteroaryl, -SR b -S(=O)R a -S(=O)2R a -S(=O)2OR b -S(=O)2NR c R d , -NR c S(=O)2R a , -NR c S(=O)R a , -NR c S(=O)2OR b , -NR cS(=O)2NR c R d , -NR b C(=O)NR c R d , -NR b C(=O)R a , -NR b C(=O)OR b -OS(=O)2R a -OS(=O)2OR b -OS(=O)2NR c R d -OC(=O)R a , -OC(=O)OR b -OC(=O)NR c R d -C(=O)R a , -C(=O)OR b , or -C(=O)NR c R d Alkyl, alkoxy, alkylamino, alkenyl, alkynyl, carbocykyl, heterocyclyl, aryl, or heteroaryl is one or more R u It may also be replaced with k is an integer selected from 0 to 4. v) Equation I-3-v TIFF2026521988000029.tif25128 (in the formula, P 1 teeth, TIFF2026521988000030.tif10128, N, or CR P1 And, P 2 teeth, TIFF2026521988000031.tif10128, N, or CR P2 And, TIFF2026521988000032.tif8128 shows adhesion to L, Each R N These are independently oxo, halogen, -CN, -NO2, -OH, -NH2, C 1-6 Alkyl, C 1-6 Alkoxy, C 1-6 Alkylamino, C 2-6 Alkenil, C2-6 Alkinyl, C 3-12 Carbocyclyl, 3-12 member heterocyclyl, C 6-10 Aryl, 5-10 member heteroaryl, -SR b -S(=O)R a -S(=O)2R a -S(=O)2OR b -S(=O)2NR c R d , -NR c S(=O)2R a , -NR c S(=O)R a , -NR c S(=O)2OR b , -NR c S(=O)2NR c R d , -NR b C(=O)NR c R d , -NR b C(=O)R a , -NR b C(=O)OR b -OS(=O)2R a -OS(=O)2OR b -OS(=O)2NR c R d -OC(=O)R a , -OC(=O)OR b -OC(=O)NR c R d -C(=O)R a , -C(=O)OR b , or -C(=O)NR c R d Alkyl, alkoxy, alkylamino, alkenyl, alkynyl, carbocykyl, heterocyclyl, aryl, or heteroaryl is one or more R u It may also be replaced with n is an integer selected from 0 to 6. R P1 , R P2 , and R P3 These are independently hydrogen, halogen, -CN, -NO2, -OH, -NH2, C 1-6 Alkyl, C 1-6Alkoxy, C 1-6 Alkylamino, C 2-6 Alkenil, C 2-6 Alkinyl, C 3-12 Carbocyclyl, 3-12 member heterocyclyl, C 6-10 Aryl, 5-10 member heteroaryl, -SR b -S(=O)R a -S(=O)2R a -S(=O)2OR b -S(=O)2NR c R d , -NR c S(=O)2R a , -NR c S(=O)R a , -NR c S(=O)2OR b , -NR c S(=O)2NR c R d , -NR b C(=O)NR c R d , -NR b C(=O)R a , -NR b C(=O)OR b -OS(=O)2R a -OS(=O)2OR b -OS(=O)2NR c R d -OC(=O)R a , -OC(=O)OR b -OC(=O)NR c R d -C(=O)R a , -C(=O)OR b , or -C(=O)NR c R d Alkyl, alkoxy, alkylamino, alkenyl, alkynyl, carbocykyl, heterocyclyl, aryl, or heteroaryl is one or more R u It may also be replaced with, and R 4 -OH, -NH2, C 1-6 Alkyl, C 1-6 Alkoxy, C 1-6 Alkylamino, C2-6 Alkenil, C 2-6 Alkinyl, C 3-12 Carbocyclyl, 3-12 member heterocyclyl, C 6-10 The aryl or 5-10 membered heteroaryl is an alkyl, alkoxy, alkylamino, alkenyl, alkynyl, carbocykrill, heterocyclyl, aryl, or heteroaryl, which has one or more R u (May be replaced by) or vi) Equation I-3-vi TIFF2026521988000033.tif21128 (in the formula, Q 1 , NR Q1’ , C(R Q1 )2, or O, R Q1’ is hydrogen, C 1-6 Alkyl, C 2-6 Alkenil, C 2-6 Alkinyl, C 3-12 Carbocyclyl, 3-12 member heterocyclyl, C 6-10 Aryl, 5-10 member heteroaryl, -S(=O)2R a -S(=O)2OR b -S(=O)2NR c R d -C(=O)R a , -C(=O)OR b , or -C(=O)NR c R d Alkyl, alkenyl, alkynyl, carbocykyl, heterocyclyl, aryl, or heteroaryl is one or more R u It may also be replaced with Each R Q1 These are independently hydrogen, halogen, -CN, -NO2, -OH, -NH2, C 1-6 Alkyl, C 1-6 Alkoxy, C 1-6 Alkylamino, C 2-6 Alkenil, C 2-6 Alkinyl, C 3-12 Carbocyclyl, 3-12 member heterocyclyl, C 6-10The aryl or 5-10 membered heteroaryl is an alkyl, alkoxy, alkylamino, alkenyl, alkynyl, carbocykrill, heterocyclyl, aryl, or heteroaryl, which has one or more R u Is it okay if it is replaced with, or Two R's Q1 Together with the carbon atoms to which they are bonded, C 3-6 It forms a carbocyclic ring or a 3- to 6-membered heterocyclic ring, and the carbocyclic ring or heterocyclic ring has one or more R u It may also be replaced with If TIFF2026521988000034.tif1128 has a double bond, Q 2 is N or CR Q2 Q 3 is N or CR Q3 And, If TIFF2026521988000035.tif1128 is a single join, Q 2 is NR Q2’ , C(R Q2 )2, or O, Q 3 is NR Q3’ , C(R Q3 )2, or O, R Q2’ and R Q3’ These are, independently, hydrogen and C 1-6 Alkyl, C 2-6 Alkenil, C 2-6 Alkinyl, C 3-12 Carbocyclyl, 3-12 member heterocyclyl, C 6-10 Aryl, 5-10 member heteroaryl, -S(=O)2R a -S(=O)2OR b -S(=O)2NR c R d -C(=O)R a , -C(=O)OR b , or -C(=O)NR c R d Alkyl, alkenyl, alkynyl, carbocykyl, heterocyclyl, aryl, or heteroaryl is one or more R u It may also be replaced with RQ2 and R Q3 Each occurrence is independently of hydrogen, halogen, -CN, -NO2, -OH, -NH2, C 1-6 Alkyl, C 1-6 Alkoxy, C 1-6 Alkylamino, C 2-6 Alkenil, C 2-6 Alkinyl, C 3-12 Carbocyclyl, 3-12 member heterocyclyl, C 6-10 The aryl or 5-10 membered heteroaryl is an alkyl, alkoxy, alkylamino, alkenyl, alkynyl, carbocykrill, heterocyclyl, aryl, or heteroaryl, which has one or more R u Is it okay if it is replaced with, or Two R's Q2 or two R's Q3 Together with the carbon atoms to which they are bonded, C 3-6 It forms a carbocyclic ring or a 3- to 6-membered heterocyclic ring, and the carbocyclic ring or heterocyclic ring has one or more R u It may also be replaced with S 1 CR S1 or N, S 2 teeth TIFF2026521988000036.tif8128,CR S2 , or N, S 3 teeth TIFF2026521988000037.tif8128,CR S3 , or N, S 4 teeth TIFF2026521988000038.tif8128,CR S4 , or N, TIFF2026521988000039.tif8128 shows adhesion to L, and R S1 , R S2 , R S3 , and R S4 These are independently hydrogen, halogen, -CN, -NO2, -OH, -NH2, C 1-6Alkyl, C 1-6 Alkoxy, C 1-6 Alkylamino, C 2-6 Alkenil, C 2-6 Alkinyl, C 3-12 Carbocyclyl, 3-12 member heterocyclyl, C 6-10 Aryl, 5-10 member heteroaryl, -SR b -S(=O)R a -S(=O)2R a -S(=O)2OR b -S(=O)2NR c R d , -NR c S(=O)2R a , -NR c S(=O)R a , -NR c S(=O)2OR b , -NR c S(=O)2NR c R d , -NR b C(=O)NR c R d , -NR b C(=O)R a , -NR b C(=O)OR b -OS(=O)2R a -OS(=O)2OR b -OS(=O)2NR c R d -OC(=O)R a , -OC(=O)OR b -OC(=O)NR c R d -C(=O)R a , -C(=O)OR b , or -C(=O)NR c R d Alkyl, alkoxy, alkylamino, alkenyl, alkynyl, carbocykyl, heterocyclyl, aryl, or heteroaryl is one or more R u (It may be replaced by) L is the expression in equation I-2'', TIFF2026521988000040.tif10128In formula, * indicates adhesion to C. Cy 1 teeth, The filename is TIFF2026521988000041.tif20128, and in the formula, TIFF2026521988000042.tif6128 shows adhesion to T, T 1 CR T1 or N, V 1 CR V1 or N, V 2 CR V2 or N, R T1 , R V1 , and R V2 These are independently hydrogen, halogen, -CN, -NO2, -OH, -NH2, C 1-6 Alkyl, C 1-6 Alkoxy, C 1-6 Alkylamino, C 3-4 Carbocyclyl, or 3-4 membered heterocyclyl, wherein alkyl, alkoxy, alkylamino, carbocyclyl, or heterocyclyl is one or more R u It may also be replaced with Each R T These are, independently, halogen, -CN, -NO2, -OH, -NH2, C 1-6 Alkyl, C 1-6 Alkoxy, C 1-6 Alkylamino, C 3-4 Carbocyclyl, or 3-4 membered heterocyclyl, wherein alkyl, alkoxy, alkylamino, carbocyclyl, or heterocyclyl is one or more R u It may also be replaced with t is an integer selected from 0 to 6, as long as the valence allows, or Cy 1 teeth, TIFF2026521988000043.tif23128, and in the formula, If TIFF2026521988000044.tif1128 has a double bond, Y 1 C is, If TIFF2026521988000045.tif1128 is a single join, Y 1 is N or CR Y1 And, TIFF2026521988000046.tif6128 shows adhesion to T, R Y1 These are hydrogen, halogen, -CN, -NO2, -OH, -NH2, C 1-6 Alkyl, C 1-6 Alkoxy, C 1-6 Alkylamino, C 3-4 Carbocyclyl, or 3-4 membered heterocyclyl, wherein alkyl, alkoxy, alkylamino, carbocyclyl, or heterocyclyl is one or more R u It may also be replaced with Y 2 C(R Y2 )2, O, or N(R Y2’ ) and Each R Y2 These are independently hydrogen, halogen, -CN, -NO2, -OH, -NH2, C 1-6 Alkyl, C 1-6 Alkoxy, C 1-6 Alkylamino, C 3-4 Carbocyclyl, or 3-4 membered heterocyclyl, wherein alkyl, alkoxy, alkylamino, carbocyclyl, or heterocyclyl is one or more R u It may also be replaced with R Y2’ is hydrogen, C 1-6 Alkyl, C 3-4 Carbocyclyl, 3-4 member heterocyclyl, -S(=O)2R a -S(=O)2OR b -S(=O)2NR c R d -C(=O)R a , -C(=O)OR b , or -C(=O)NR c R d And alkyl, carbocyryl, or heterocyclyl is one or more R u It may also be replaced with Z1 CR Z1 or N, Z 2 CR Z2 or N, R Z1 and R Z2 These are independently hydrogen, halogen, -CN, -NO2, -OH, -NH2, C 1-6 Alkyl, C 1-6 Haloalkyl, C 1-6 Alkoxy, C 1-6 Alkylamino, C 3-4 Carbocyclyl, 3-4 membered heterocyclyl, alkyl, alkoxy, alkylamino, carbocyclyl, or heterocyclyl may have one or more R u It may also be replaced with Each R Z These are independently oxo, halogen, -CN, -NO2, -OH, -NH2, C 1-6 Alkyl, C 1-6 Alkoxy, C 1-6 Alkylamino, C 3-4 Carbocyclyl, or 3-4 membered heterocyclyl, wherein alkyl, alkoxy, alkylamino, carbocyclyl, or heterocyclyl is one or more R u It may also be replaced with z is an integer selected from 0 to 6, as long as the valence allows. Here, R Z It may exist in either ring Y or ring Z. Cy 2 These are C6 arylenes or 5-6 member heteroarylenes, and each arylene or heteroarylene is composed of one or more R u It may also be replaced with L 2 CH2 or CH(C 1-3 It is alkyl, L 3 is E-ethenylene, ethynylene, C6 arylene, or 5-6 member heteroarylene, and E-ethenylene, arylene, or heteroarylene contains one or more R u It may also be replaced with Here, Each R u These are independently oxo, halogen, -CN, -NO2, -OH, -NH2, C 1-6 Alkyl, C 1-6 Alkoxy, C 1-6 Alkylamino, C 3-4 Carbocyclyl, or 3-6 membered heterocyclyl, Each R a C 1-6 Alkyl, C 3-6 Carbocyclyl, or 3-6 membered heterocyclyl, Each R b These are, independently, hydrogen and C 1-6 Alkyl, C 3-6 Carbocyclyl, or 3-6 membered heterocyclyl, R c and R d Each of them independently consists of hydrogen and C. 1-6 Alkyl, C 3-6 It is either a carbocyclyl or a 3-6 member heterocyclyl, or R c and R d These, together with the nitrogen atom to which they are bonded, form a 3-6 membered heterocycline. R a , R b , R c , and R d Each occurrence of is independent and is associated with one or more R z It may also be replaced with Each R z These are independently oxo, halogen, -CN, -NO2, -OH, -NH2, C 1-6 Alkyl, C 1-6 Alkoxy, C 1-6 Alkylamino, C 3-6 They are carbocyclyls, or 3- to 6-membered heterocyclyls.

[0010] In certain embodiments, this disclosure relates to compounds of formula I: TLC(I), The formula provides a pharmaceutically acceptable salt, solvate, or stereoisomer thereof, wherein, C is the expression in equation I-1', In TIFF2026521988000047.tif38128, In TIFF2026521988000048.tif8128, it indicates the attachment to L, B 1 is CR B1 or N, B 3 is CR B3 or N, B 4 is CR B4 or N, B 5 is CR B5 or N, B 6 is C or N, R B1 R B3 R B4 and R B5 are independently oxo, hydrogen, halogen, -CN, -NO2, -OH, -NH2, C 1-6 alkyl, C 1-6 alkoxy, C 1-6 alkylamino, C 3-4 carbocyclic, or 3- to 4-membered heterocyclic, and alkyl, alkoxy, alkylamino, carbocyclic, or heterocyclic may be substituted with one or more R u and X is absent, O, or NR X and R X is hydrogen, C 1-3 alkyl, C 3-4 carbocyclic, or 3- to 4-membered heterocyclic, R D1 is hydrogen, deuterium, or C 1-6 alkyl, each R D is independently halogen, -CN, -NO2, -OH, -NH2, C 1-6 alkyl, C 1-6 alkoxy, C 1-6 alkylamino, C 3-4Carbocyclyl, or 3-4 membered heterocyclyl, wherein alkyl, alkoxy, alkylamino, carbocyclyl, or heterocyclyl is one or more R u It may also be replaced with d is an integer between 0 and 6, as long as the valence allows. q is an integer between 0 and 2. T is i) Equation I-3-i TIFF2026521988000049.tif25128 (in the formula, E 1 teeth, TIFF2026521988000050.tif8128,CR E1 , or N, E 2 teeth, TIFF2026521988000051.tif8128,CR E2 , or N, E 3 teeth, TIFF2026521988000052.tif10128,CR E3 , or N, TIFF2026521988000053.tif8128 shows adhesion to L, R E1 , R E2 , R E3 , and R E4 These are independently hydrogen, halogen, -CN, -NO2, -OH, -NH2, C 1-6 Alkyl, C 1-6 Alkoxy, C 1-6 Alkylamino, C 2-6 Alkenil, C 2-6 Alkinyl, C 3-12 Carbocyclyl, 3-12 member heterocyclyl, C 6-10 Aryl, 5-10 member heteroaryl, -SR b -S(=O)R a -S(=O)2R a -S(=O)2OR b -S(=O)2NR c R d , -NR c S(=O)2Ra 、 -NR c S(=O)R a 、 -NR c S(=O)2OR b 、 -NR c S(=O)2NR c R d 、 -NR b C(=O)NR c R d 、 -NR b C(=O)R a 、 -NR b C(=O)OR b 、 -OS(=O)2R a 、 -OS(=O)2OR b 、 -OS(=O)2NR c R d ​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​, or -C(=O)NR c R d Alkyl, alkenyl, alkynyl, carbocykyl, heterocyclyl, aryl, or heteroaryl is one or more R u It may also be replaced with R F2 These are hydrogen, halogen, -CN, -NO2, -OH, -NH2, C 1-6 Alkyl, C 1-6 Alkoxy, C 1-6 Alkylamino, C 2-6 Alkenil, C 2-6 Alkinyl, C 3-12 Carbocyclyl, 3-12 member heterocyclyl, C 6-10 Aryl, 5-10 member heteroaryl, -SR b -S(=O)R a -S(=O)2R a -S(=O)2OR b -S(=O)2NR c R d , -NR c S(=O)2R a , -NR c S(=O)R a , -NR c S(=O)2OR b , -NR c S(=O)2NR c R d , -NR b C(=O)NR c R d , -NR b C(=O)R a , -NR b C(=O)OR b -OS(=O)2R a -OS(=O)2OR b -OS(=O)2NR c R d -OC(=O)R a , -OC(=O)OR b -OC(=O)NR c R d -C(=O)R a , -C(=O)OR b , or -C(=O)NR c R dAlkyl, alkoxy, alkylamino, alkenyl, alkynyl, carbocykyl, heterocyclyl, aryl, or heteroaryl is one or more R u It may also be replaced with F 3 CR F3 , N, or NR F3’ And, R F3 These are hydrogen, halogen, -CN, -NO2, -OH, -NH2, C 1-6 Alkyl, C 1-6 Alkoxy, C 1-6 Alkylamino, C 2-6 Alkenil, C 2-6 Alkinyl, C 3-12 Carbocyclyl, 3-12 member heterocyclyl, C 6-10 Aryl, 5-10 member heteroaryl, -SR b -S(=O)R a -S(=O)2R a -S(=O)2OR b -S(=O)2NR c R d , -NR c S(=O)2R a , -NR c S(=O)R a , -NR c S(=O)2OR b , -NR c S(=O)2NR c R d , -NR b C(=O)NR c R d , -NR b C(=O)R a , -NR b C(=O)OR b -OS(=O)2R a -OS(=O)2OR b -OS(=O)2NR c R d -OC(=O)R a , -OC(=O)OR b -OC(=O)NR c R d -C(=O)R a , -C(=O)ORb , or -C(=O)NR c R d Alkyl, alkoxy, alkylamino, alkenyl, alkynyl, carbocykyl, heterocyclyl, aryl, or heteroaryl is one or more R u It may also be replaced with R F3’ is hydrogen, C 1-6 Alkyl, C 2-6 Alkenil, C 2-6 Alkinyl, C 3-12 Carbocyclyl, 3-12 member heterocyclyl, C 6-10 Aryl, 5-10 member heteroaryl, -S(=O)2R a -S(=O)2OR b -S(=O)2NR c R d -C(=O)R a , -C(=O)OR b , or -C(=O)NR c R d Alkyl, alkenyl, alkynyl, carbocykyl, heterocyclyl, aryl, or heteroaryl is one or more R u It may also be replaced with R F4 is -C(=O)NR 3a R 3b , or one or more R u It is a 5-6 member heteroaryl which may be substituted with R 3a and R 3b These are, independently, hydrogen and C 1-6 Alkyl, C 2-6 Alkenil, C 2-6 Alkinyl, C 3-12 Carbocyclyl, 3-12 member heterocyclyl, C 6-10 Aryl, 5-10 member heteroaryl, -S(=O)2R a -S(=O)2OR b -S(=O)2NR c R d -C(=O)R a , -C(=O)OR b , or -C(=O)NR c Rd Alkyl, alkenyl, alkynyl, carbocykyl, heterocyclyl, aryl, or heteroaryl is one or more R u It may also be replaced with R 3a and R 3b These, together with the nitrogen atoms to which they are bonded, form a 3-12 membered heterocycle or a 5-10 membered heteroaryl, and the heterocycle or heteroaryl contains one or more R u (May be replaced by) ii) Formula I-3-ii TIFF2026521988000054.tif28128 (in the formula, G 1 teeth, TIFF2026521988000055.tif8128, N, or CR G1 And, G 2 teeth, TIFF2026521988000056.tif8128, N, or CR G2 And, G 3 teeth, TIFF2026521988000057.tif8128, N, or CR G3 And, TIFF2026521988000058.tif8128 shows adhesion to L, R G1 , R G2 , R G3 , and R G4 These are independently hydrogen, halogen, -CN, -NO2, -OH, -NH2, C 1-6 Alkyl, C 1-6 Alkoxy, C 1-6 Alkylamino, C 2-6 Alkenil, C 2-6 Alkinyl, C 3-12 Carbocyclyl, 3-12 member heterocyclyl, C 6-10 Aryl, 5-10 member heteroaryl, -SR b -S(=O)R a -S(=O)2R a -S(=O)2ORb -S(=O)2NR c R d , -NR c S(=O)2R a , -NR c S(=O)R a , -NR c S(=O)2OR b , -NR c S(=O)2NR c R d , -NR b C(=O)NR c R d , -NR b C(=O)R a , -NR b C(=O)OR b -OS(=O)2R a -OS(=O)2OR b -OS(=O)2NR c R d -OC(=O)R a , -OC(=O)OR b -OC(=O)NR c R d -C(=O)R a , -C(=O)OR b , or -C(=O)NR c R d Alkyl, alkoxy, alkylamino, alkenyl, alkynyl, carbocykyl, heterocyclyl, aryl, or heteroaryl is one or more R u It may also be replaced with H 1 C(R H1 )2, NR H1’ , or O, H 2 C(R H2 )2, NR H2’ , or O, R H1 and R H2 Each occurrence is independently of hydrogen, halogen, -CN, -NO2, -OH, -NH2, C 1-6 Alkyl, C 1-6 Alkoxy, C 1-6 Alkylamino, C 2-6 Alkenil, C 2-6Alkinyl, C 3-12 Carbocyclyl, 3-12 member heterocyclyl, C 6-10 The aryl or 5-10 membered heteroaryl is an alkyl, alkoxy, alkylamino, alkenyl, alkynyl, carbocykrill, heterocyclyl, aryl, or heteroaryl, which has one or more R u Is it okay if it is replaced with, or Two R's H1 or two R's H2 Together with the carbon atoms to which they are bonded, C 3-6 It forms a carbocyclic ring or a 3- to 6-membered heterocyclic ring, and the carbocyclic ring or heterocyclic ring has one or more R u It may also be replaced with R H1’ and R H2’ Hydrogen and C are independent of each other. 1-6 Alkyl, C 3-6 Carbocyclyl, 3-6 member heterocyclyl, -S(=O)2R a -S(=O)2OR b -S(=O)2NR c R d -C(=O)R a , -C(=O)OR b , or -C(=O)NR c R d And alkyl, carbocykryl, or heterocyclyl is one or more R u (May be replaced by) iii) Equation I-3-iii TIFF2026521988000059.tif28128 (in the formula, TIFF2026521988000060.tif8128 shows adhesion to L, I 1 C(R I1 )2, NR I1’ , or O, I 2 C(R I2 )2, NR I2’ , or O, R I1 and R I2Each occurrence is independently of hydrogen, halogen, -CN, -NO2, -OH, -NH2, C 1-6 Alkyl, C 1-6 Alkoxy, C 1-6 Alkylamino, C 2-6 Alkenil, C 2-6 Alkinyl, C 3-12 Carbocyclyl, 3-12 member heterocyclyl, C 6-10 The aryl or 5-10 membered heteroaryl is an alkyl, alkoxy, alkylamino, alkenyl, alkynyl, carbocykrill, heterocyclyl, aryl, or heteroaryl, which has one or more R u Is it okay if it is replaced with, or Two R's I1 or two R's I2 Together with the carbon atoms to which they are bonded, C 3-6 It forms a carbocyclic ring or a 3- to 6-membered heterocyclic ring, and the carbocyclic ring or heterocyclic ring has one or more R u It may also be replaced with R I1’ and R I2’ Hydrogen and C are independent of each other. 1-6 Alkyl, C 3-6 Carbocyclyl, 3-6 member heterocyclyl, -S(=O)2R a -S(=O)2OR b -S(=O)2NR c R d -C(=O)R a , -C(=O)OR b , or -C(=O)NR c R d And alkyl, carbocykryl, or heterocyclyl is one or more R u It may also be replaced with Each R I These are independently oxo, halogen, -CN, -NO2, -OH, -NH2, C 1-6 Alkyl, C 1-6 Alkoxy, C 1-6 Alkylamino, C 2-6 Alkenil, C 2-6 Alkinyl, C 3-12 Carbocyclyl, 3-12 member heterocyclyl, C 6-10Aryl, 5-10 member heteroaryl, -SR b -S(=O)R a -S(=O)2R a -S(=O)2OR b -S(=O)2NR c R d , -NR c S(=O)2R a , -NR c S(=O)R a , -NR c S(=O)2OR b , -NR c S(=O)2NR c R d , -NR b C(=O)NR c R d , -NR b C(=O)R a , -NR b C(=O)OR b -OS(=O)2R a -OS(=O)2OR b -OS(=O)2NR c R d -OC(=O)R a , -OC(=O)OR b -OC(=O)NR c R d -C(=O)R a , -C(=O)OR b , or -C(=O)NR c R d Alkyl, alkoxy, alkylamino, alkenyl, alkynyl, carbocykyl, heterocyclyl, aryl, or heteroaryl is one or more R u It may also be replaced with i is an integer selected from 0 to 4. J 1 is N or CR J1 And, J 2 is N or CR J2 And, R J1 , R J2 , and R J3 These are independently hydrogen, halogen, -CN, -NO2, -OH, -NH2, C1-6 Alkyl, C 1-6 Alkoxy, C 1-6 Alkylamino, C 2-6 Alkenil, C 2-6 Alkinyl, C 3-12 Carbocyclyl, 3-12 member heterocyclyl, C 6-10 Aryl, 5-10 member heteroaryl, -SR b -S(=O)R a -S(=O)2R a -S(=O)2OR b -S(=O)2NR c R d , -NR c S(=O)2R a , -NR c S(=O)R a , -NR c S(=O)2OR b , -NR c S(=O)2NR c R d , -NR b C(=O)NR c R d , -NR b C(=O)R a , -NR b C(=O)OR b -OS(=O)2R a -OS(=O)2OR b -OS(=O)2NR c R d -OC(=O)R a , -OC(=O)OR b -OC(=O)NR c R d -C(=O)R a , -C(=O)OR b , or -C(=O)NR c R d Alkyl, alkoxy, alkylamino, alkenyl, alkynyl, carbocykyl, heterocyclyl, aryl, or heteroaryl is one or more R u (May be replaced by) iv) Equation I-3-iv TIFF2026521988000061.tif21128 (in the formula, M 1 [is either N or C,]は、NまたはCであり、 [where M]M 2 [is]は、 [TIFF2026521988000062.tif10128, N, or CR]TIFF2026521988000062.tif10128、N、またはCR M2 [and]であり、 [where M]M 3 [is]は、 [TIFF2026521988000063.tif10128, N, or CR]TIFF2026521988000063.tif10128、N、またはCR M3 [and]であり、 [where M]M 4 [is]は、 [TIFF2026521988000064.tif(10128), N, or CR]TIFF2026521988000064.tif10128、Nに、またはCR M4 [and]であり、 [where]式中、 [TIFF2026521988000065.tif8128 indicates attachment to L, and M]TIFF2026521988000065.tif8128は、Lへの付着を示し、M 1 [, M]、M 2 [, M]、M 3 [, and M]、およびM 4 [at least one of which is N or]のうちの少なくとも1つは、Nまたは [TIFF2026521988000066.tif8128 and]TIFF2026521988000066.tif8128であり、 [where R]R M2 [, R]、R M3 [, and R]およびR M4 [are independently hydrogen, halogen, -CN, -NO2, -OH, -NH2, C]は独立して、水素、ハロゲン、-CN、-NO2、-OH、-NH2、C 1-6 [alkyl, C]アルキル、C 1-6 [alkoxy, C]アルコキシ、C 1-6 [alkylamino, C]アルキルアミノ、C 2-6 [alkenyl, C]アルケニル、C 2-6 [alkynyl, C]アルキニル、C 3-12 [carbocyclic, 3 - 12 member heterocyclic, C]カルボシクリル、3~12員ヘテロシクリル、C 6-10 [aryl, 5 - 10 member heteroaryl, -SR]アリール、5~10員ヘテロアリール、-SR b [, -S(=O)R]、-S(=O)R a [, -S(=O)2R]、-S(=O)2R a [, -S(=O)2OR]、-S(=O)2OR b [, -S(=O)2NR]、-S(=O)2NR c [R]R d [, -NR]、-NR c [S(=O)2R]S(=O)2R a [, -NR]、-NR c [S(=O)R]S(=O)R a [, -NR]、-NR c [S(=O)2OR]S(=O)2OR b [, -NR]、-NRc S(=O)2NR c R d , -NR b C(=O)NR c R d , -NR b C(=O)R a , -NR b C(=O)OR b -OS(=O)2R a -OS(=O)2OR b -OS(=O)2NR c R d -OC(=O)R a , -OC(=O)OR b -OC(=O)NR c R d -C(=O)R a , -C(=O)OR b , or -C(=O)NR c R d Alkyl, alkoxy, alkylamino, alkenyl, alkynyl, carbocykyl, heterocyclyl, aryl, or heteroaryl is one or more R u It may also be replaced with R K’ is hydrogen, C 1-6 Alkyl, C 2-6 Alkenil, C 2-6 Alkinyl, C 3-12 Carbocyclyl, 3-12 member heterocyclyl, C 6-10 Aryl, 5-10 member heteroaryl, -S(=O)2R a -S(=O)2OR b -S(=O)2NR c R d -C(=O)R a , -C(=O)OR b , or -C(=O)NR c R d Alkyl, alkenyl, alkynyl, carbocykyl, heterocyclyl, aryl, or heteroaryl is one or more R u It may also be replaced with K 1 is -C(=O)- or -C(R K1 )2-, Each R K1 These are independently hydrogen, halogen, -CN, -NO2, -OH, -NH2, C 1-6 Alkyl, C 1-6 Alkoxy, C 1-6 Alkylamino, C 2-6 Alkenil, C 2-6 Alkinyl, C 3-12 Carbocyclyl, 3-12 member heterocyclyl, C 6-10 The aryl or 5-10 membered heteroaryl is an alkyl, alkoxy, alkylamino, alkenyl, alkynyl, carbocykrill, heterocyclyl, aryl, or heteroaryl, which has one or more R u It may also be replaced with Each R K These are independently oxo, hydrogen, halogen, -CN, -NO2, -OH, -NH2, C 1-6 Alkyl, C 1-6 Alkoxy, C 1-6 Alkylamino, C 2-6 Alkenil, C 2-6 Alkinyl, C 3-12 Carbocyclyl, 3-12 member heterocyclyl, C 6-10 Aryl, 5-10 member heteroaryl, -SR b -S(=O)R a -S(=O)2R a -S(=O)2OR b -S(=O)2NR c R d , -NR c S(=O)2R a , -NR c S(=O)R a , -NR c S(=O)2OR b , -NR c S(=O)2NR c R d , -NR b C(=O)NR c R d , -NR b C(=O)R a , -NR b C(=O)OR b -OS(=O)2R a -OS(=O)2OR b-OS(=O)2NR c R d -OC(=O)R a , -OC(=O)OR b -OC(=O)NR c R d -C(=O)R a , -C(=O)OR b , or -C(=O)NR c R d Alkyl, alkoxy, alkylamino, alkenyl, alkynyl, carbocykyl, heterocyclyl, aryl, or heteroaryl is one or more R u It may also be replaced with k is an integer selected from 0 to 4. v) Equation I-3-v TIFF2026521988000067.tif25128 (in the formula, P 1 teeth, TIFF2026521988000068.tif10128, N, or CR P1 And, P 2 teeth, TIFF2026521988000069.tif10128, N, or CR P2 And, TIFF2026521988000070.tif8128 shows adhesion to L, Each R N These are independently oxo, halogen, -CN, -NO2, -OH, -NH2, C 1-6 Alkyl, C 1-6 Alkoxy, C 1-6 Alkylamino, C 2-6 Alkenil, C 2-6 Alkinyl, C 3-12 Carbocyclyl, 3-12 member heterocyclyl, C 6-10 Aryl, 5-10 member heteroaryl, -SR b -S(=O)R a -S(=O)2R a -S(=O)2OR b -S(=O)2NR c R d , -NRc S(=O)2R a , -NR c S(=O)R a , -NR c S(=O)2OR b , -NR c S(=O)2NR c R d , -NR b C(=O)NR c R d , -NR b C(=O)R a , -NR b C(=O)OR b -OS(=O)2R a -OS(=O)2OR b -OS(=O)2NR c R d -OC(=O)R a , -OC(=O)OR b -OC(=O)NR c R d -C(=O)R a , -C(=O)OR b , or -C(=O)NR c R d Alkyl, alkoxy, alkylamino, alkenyl, alkynyl, carbocykyl, heterocyclyl, aryl, or heteroaryl is one or more R u It may also be replaced with n is an integer selected from 0 to 6. R P1 , R P2 , and R P3 These are independently hydrogen, halogen, -CN, -NO2, -OH, -NH2, C 1-6 Alkyl, C 1-6 Alkoxy, C 1-6 Alkylamino, C 2-6 Alkenil, C 2-6 Alkinyl, C 3-12 Carbocyclyl, 3-12 member heterocyclyl, C 6-10 Aryl, 5-10 member heteroaryl, -SR b -S(=O)R a -S(=O)2R a -S(=O)2OR b-S(=O)2NR c R d , -NR c S(=O)2R a , -NR c S(=O)R a , -NR c S(=O)2OR b , -NR c S(=O)2NR c R d , -NR b C(=O)NR c R d , -NR b C(=O)R a , -NR b C(=O)OR b -OS(=O)2R a -OS(=O)2OR b -OS(=O)2NR c R d -OC(=O)R a , -OC(=O)OR b -OC(=O)NR c R d -C(=O)R a , -C(=O)OR b , or -C(=O)NR c R d Alkyl, alkoxy, alkylamino, alkenyl, alkynyl, carbocykyl, heterocyclyl, aryl, or heteroaryl is one or more R u It may also be replaced with, and R 4 -OH, -NH2, C 1-6 Alkyl, C 1-6 Alkoxy, C 1-6 Alkylamino, C 2-6 Alkenil, C 2-6 Alkinyl, C 3-12 Carbocyclyl, 3-12 member heterocyclyl, C 6-10 The aryl or 5-10 membered heteroaryl is an alkyl, alkoxy, alkylamino, alkenyl, alkynyl, carbocykrill, heterocyclyl, aryl, or heteroaryl, which has one or more R u (May be replaced by) or vi) Equation I-3-vi TIFF2026521988000071.tif21128 (in the formula, Q 1 , NR Q1’ , C(R Q1 )2, or O, R Q1’ is hydrogen, C 1-6 Alkyl, C 2-6 Alkenil, C 2-6 Alkinyl, C 3-12 Carbocyclyl, 3-12 member heterocyclyl, C 6-10 Aryl, 5-10 member heteroaryl, -S(=O)2R a -S(=O)2OR b -S(=O)2NR c R d -C(=O)R a , -C(=O)OR b , or -C(=O)NR c R d Alkyl, alkenyl, alkynyl, carbocykyl, heterocyclyl, aryl, or heteroaryl is one or more R u It may also be replaced with Each R Q1 These are independently hydrogen, halogen, -CN, -NO2, -OH, -NH2, C 1-6 Alkyl, C 1-6 Alkoxy, C 1-6 Alkylamino, C 2-6 Alkenil, C 2-6 Alkinyl, C 3-12 Carbocyclyl, 3-12 member heterocyclyl, C 6-10 The aryl or 5-10 membered heteroaryl is an alkyl, alkoxy, alkylamino, alkenyl, alkynyl, carbocykrill, heterocyclyl, aryl, or heteroaryl, which has one or more R u Is it okay if it is replaced with, or Two R's Q1 Together with the carbon atoms to which they are bonded, C 3-6 It forms a carbocyclic ring or a 3- to 6-membered heterocyclic ring, and the carbocyclic ring or heterocyclic ring has one or more R uIt may also be replaced with If TIFF2026521988000072.tif2128 has a double bond, Q 2 is N or CR Q2 Q 3 is N or CR Q3 And, If TIFF2026521988000073.tif1128 is a single join, Q 2 is NR Q2’ , C(R Q2 )2, or O, Q 3 is NR Q3’ , C(R Q3 )2, or O, R Q2’ and R Q3’ These are, independently, hydrogen and C 1-6 Alkyl, C 2-6 Alkenil, C 2-6 Alkinyl, C 3-12 Carbocyclyl, 3-12 member heterocyclyl, C 6-10 Aryl, 5-10 member heteroaryl, -S(=O)2R a -S(=O)2OR b -S(=O)2NR c R d -C(=O)R a , -C(=O)OR b , or -C(=O)NR c R d Alkyl, alkenyl, alkynyl, carbocykyl, heterocyclyl, aryl, or heteroaryl is one or more R u It may also be replaced with R Q2 and R Q3 Each occurrence is independently of hydrogen, halogen, -CN, -NO2, -OH, -NH2, C 1-6 Alkyl, C 1-6 Alkoxy, C 1-6 Alkylamino, C 2-6 Alkenil, C 2-6 Alkinyl, C 3-12 Carbocyclyl, 3-12 member heterocyclyl, C 6-10The aryl or 5-10 membered heteroaryl is an alkyl, alkoxy, alkylamino, alkenyl, alkynyl, carbocykrill, heterocyclyl, aryl, or heteroaryl, which has one or more R u Is it okay if it is replaced with, or Two R's Q2 or two R's Q3 Together with the carbon atoms to which they are bonded, C 3-6 It forms a carbocyclic ring or a 3- to 6-membered heterocyclic ring, and the carbocyclic ring or heterocyclic ring has one or more R u It may also be replaced with S 1 CR S1 or N, S 2 teeth TIFF2026521988000074.tif8128,CR S2 , or N, S 3 teeth TIFF2026521988000075.tif8128,CR S3 , or N, S 4 teeth, TIFF2026521988000076.tif8128,CR S4 , or N, TIFF2026521988000077.tif8128 shows adhesion to L, and R S1 , R S2 , R S3 , and R S4 These are independently hydrogen, halogen, -CN, -NO2, -OH, -NH2, C 1-6 Alkyl, C 1-6 Alkoxy, C 1-6 Alkylamino, C 2-6 Alkenil, C 2-6 Alkinyl, C 3-12 Carbocyclyl, 3-12 member heterocyclyl, C 6-10 Aryl, 5-10 member heteroaryl, -SR b -S(=O)R a -S(=O)2R a-S(=O)2OR b -S(=O)2NR c R d , -NR c S(=O)2R a , -NR c S(=O)R a , -NR c S(=O)2OR b , -NR c S(=O)2NR c R d , -NR b C(=O)NR c R d , -NR b C(=O)R a , -NR b C(=O)OR b -OS(=O)2R a -OS(=O)2OR b -OS(=O)2NR c R d -OC(=O)R a , -OC(=O)OR b -OC(=O)NR c R d -C(=O)R a , -C(=O)OR b , or -C(=O)NR c R d Alkyl, alkoxy, alkylamino, alkenyl, alkynyl, carbocykyl, heterocyclyl, aryl, or heteroaryl is one or more R u (It may be replaced by) L is the expression in equation I-2', TIFF2026521988000078.tif10128In formula, * indicates adhesion to C. Cy 1 teeth, The filename is TIFF2026521988000079.tif20128, and in the formula, TIFF2026521988000080.tif6128 shows adhesion to T, T 1 CR T1 or N, V1 CR V1 or N, V 2 CR V2 or N, R T1 , R V1 , and R V2 These are independently hydrogen, halogen, -CN, -NO2, -OH, -NH2, C 1-6 Alkyl, C 1-6 Alkoxy, C 1-6 Alkylamino, C 3-4 Carbocyclyl, or 3-4 membered heterocyclyl, wherein alkyl, alkoxy, alkylamino, carbocyclyl, or heterocyclyl is one or more R u It may also be replaced with Each R T These are, independently, halogen, -CN, -NO2, -OH, -NH2, C 1-6 Alkyl, C 1-6 Alkoxy, C 1-6 Alkylamino, C 3-4 Carbocyclyl, or 3-4 membered heterocyclyl, wherein alkyl, alkoxy, alkylamino, carbocyclyl, or heterocyclyl is one or more R u It may also be replaced with t is an integer selected from 0 to 6, as long as the valence allows, or Cy 1 teeth, The filename is TIFF2026521988000081.tif19128, and in the formula, Y 1 is N or CR Y1 And, TIFF2026521988000082.tif6128 shows adhesion to T, R Y1 These are hydrogen, halogen, -CN, -NO2, -OH, -NH2, C 1-6 Alkyl, C 1-6 Alkoxy, C 1-6 Alkylamino, C 3-4Carbocyclyl, or 3-4 membered heterocyclyl, wherein alkyl, alkoxy, alkylamino, carbocyclyl, or heterocyclyl is one or more R u It may also be replaced with Y 2 C(R Y2 )2, O, or N(R Y2’ ) and Each R Y2 These are independently hydrogen, halogen, -CN, -NO2, -OH, -NH2, C 1-6 Alkyl, C 1-6 Alkoxy, C 1-6 Alkylamino, C 3-4 Carbocyclyl, or 3-4 membered heterocyclyl, wherein alkyl, alkoxy, alkylamino, carbocyclyl, or heterocyclyl is one or more R u It may also be replaced with R Y2’ is hydrogen, C 1-6 Alkyl, C 3-4 Carbocyclyl, 3-4 member heterocyclyl, -S(=O)2R a -S(=O)2OR b -S(=O)2NR c R d -C(=O)R a , -C(=O)OR b , or -C(=O)NR c R d And alkyl, carbocykryl, or heterocyclyl is one or more R u It may also be replaced with Z 1 CR Z1 or N, R Z1 These are hydrogen, halogen, -CN, -NO2, -OH, -NH2, C 1-6 Alkyl, C 1-6 Alkoxy, C 1-6 Alkylamino, C 3-4 Carbocyclyl, 3-4 membered heterocyclyl, alkyl, alkoxy, alkylamino, carbocyclyl, or heterocyclyl may have one or more R u It may also be replaced with Each RZ These are independently oxo, halogen, -CN, -NO2, -OH, -NH2, C 1-6 Alkyl, C 1-6 Alkoxy, C 1-6 Alkylamino, C 3-4 Carbocyclyl, or 3-4 membered heterocyclyl, wherein alkyl, alkoxy, alkylamino, carbocyclyl, or heterocyclyl is one or more R u It may also be replaced with z is an integer selected from 0 to 6, as long as the valence allows. Here, R Z It may exist in either ring Y or ring Z. Cy 2 is one or more R u It is a 5-6 member heteroarylene which may be substituted with L 2 CH2 or CH(C 1-3 It is alkyl, L 3 These are E-ethenylene, ethynylene, C6 arylene, or 5-6 member heteroarylene, and E-ethenylene, arylene, or heteroarylene contains one or more R u It may also be replaced with Here, Each R u These are independently oxo, halogen, -CN, -NO2, -OH, -NH2, C 1-6 Alkyl, C 1-6 Alkoxy, C 1-6 Alkylamino, C 3-4 Carbocyclyl, or 3-4 membered heterocyclyl, Each R a Independently, C 1-6 Alkyl, C 3-6 Carbocyclyl, or 3-6 membered heterocyclyl, Each R b These are, independently, hydrogen and C 1-6 Alkyl, C 3-6 Carbocyclyl, or 3-6 membered heterocyclyl, R c and R dEach of them independently consists of hydrogen and C. 1-6 Alkyl, C 3-6 It is either a carbocyclyl or a 3-6 member heterocyclyl, or R c and R d These, together with the nitrogen atom to which they are bonded, form a 3-6 membered heterocycline. R a , R b , R c , and R d Each occurrence of is independent and is associated with one or more R z It may also be replaced with Each R z These are independently oxo, halogen, -CN, -NO2, -OH, -NH2, C 1-6 Alkyl, C 1-6 Alkoxy, C 1-6 Alkylamino, C 3-6 They are carbocyclyls, or 3- to 6-membered heterocyclyls.

[0011] In certain embodiments, this disclosure relates to a compound of formula I: TLC(I), The formula provides a pharmaceutically acceptable salt, solvate, or stereoisomer thereof, wherein, C is the expression in Equation I-1, TIFF2026521988000083.tif33128In formula, B 1 CR B1 or N, B 3 CR B3 or N, B 4 CR B4 or N, B 5 CR B5 or N, R B1 , R B3 , R B4 , and R B5 These are independently hydrogen, halogen, -CN, -NO2, -OH, -NH2, C 1-6 Alkyl, C 1-6 Alkoxy, C1-6 Alkylamino, C 3-4 Carbocyclyl, or 3-4 membered heterocyclyl, wherein alkyl, alkoxy, alkylamino, carbocyclyl, or heterocyclyl is one or more R u It may also be replaced with X is either nonexistent, O, or NR X And, R X is hydrogen, C 1-3 Alkyl, C 3-4 It is either a carbocyclyl or a 3-4 member heterocyclyl, or X is NR X and B 5 CR B5 If so, R X and R B5 These, together with the atoms to which they are bonded, form a 5-membered heteroaryl compound. R D1 is hydrogen, deuterium, or C 1-6 It is alkyl, Each R D These are, independently, halogen, -CN, -NO2, -OH, -NH2, C 1-6 Alkyl, C 1-6 Alkoxy, C 1-6 Alkylamino, C 3-4 Carbocyclyl, or 3-4 membered heterocyclyl, wherein alkyl, alkoxy, alkylamino, carbocyclyl, or heterocyclyl is one or more R u It may also be replaced with d is an integer between 0 and 6, as long as the valence allows. q is an integer between 0 and 2. T is i) Equation I-3-i TIFF2026521988000084.tif25128 (in the formula, E 1 teeth, TIFF2026521988000085.tif8128,CR E1 , or N, E 2 teeth, TIFF2026521988000086.tif8128,CR E2 , or N, E 3 teeth, TIFF2026521988000087.tif8128,CR E3 , or N, TIFF2026521988000088.tif8128 shows adhesion to L, R E1 , R E2 , R E3 , and R E4 These are independently hydrogen, halogen, -CN, -NO2, -OH, -NH2, C 1-6 Alkyl, C 1-6 Alkoxy, C 1-6 Alkylamino, C 2-6 Alkenil, C 2-6 Alkinyl, C 3-12 Carbocyclyl, 3-12 member heterocyclyl, C 6-10 Aryl, 5-10 member heteroaryl, -SR b -S(=O)R a -S(=O)2R a -S(=O)2OR b -S(=O)2NR c R d , -NR c S(=O)2R a , -NR c S(=O)R a , -NR c S(=O)2OR b , -NR c S(=O)2NR c R d , -NR b C(=O)NR c R d , -NR b C(=O)R a , -NR b C(=O)OR b -OS(=O)2R a -OS(=O)2OR b -OS(=O)2NR c R d -OC(=O)R a , -OC(=O)ORb -OC(=O)NR c R d -C(=O)R a , -C(=O)OR b , or -C(=O)NR c R d Alkyl, alkoxy, alkylamino, alkenyl, alkynyl, carbocykyl, heterocyclyl, aryl, or heteroaryl is one or more R u It may also be replaced with F 1 is C or N, F 2 , NR F2’ or CR F2 And, R F2’ is hydrogen, C 1-6 Alkyl, C 2-6 Alkenil, C 2-6 Alkinyl, C 3-12 Carbocyclyl, 3-12 member heterocyclyl, C 6-10 Aryl, 5-10 member heteroaryl, -S(=O)2R a -S(=O)2OR b -S(=O)2NR c R d -C(=O)R a , -C(=O)OR b , or -C(=O)NR c R d Alkyl, alkenyl, alkynyl, carbocykyl, heterocyclyl, aryl, or heteroaryl is one or more R u It may also be replaced with R F2 These are hydrogen, halogen, -CN, -NO2, -OH, -NH2, C 1-6 Alkyl, C 1-6 Alkoxy, C 1-6 Alkylamino, C 2-6 Alkenil, C 2-6 Alkinyl, C 3-12 Carbocyclyl, 3-12 member heterocyclyl, C 6-10 Aryl, 5-10 member heteroaryl, -SR b -S(=O)R a-S(=O)2R a -S(=O)2OR b -S(=O)2NR c R d , -NR c S(=O)2R a , -NR c S(=O)R a , -NR c S(=O)2OR b , -NR c S(=O)2NR c R d , -NR b C(=O)NR c R d , -NR b C(=O)R a , -NR b C(=O)OR b -OS(=O)2R a -OS(=O)2OR b -OS(=O)2NR c R d -OC(=O)R a , -OC(=O)OR b -OC(=O)NR c R d -C(=O)R a , -C(=O)OR b , or -C(=O)NR c R d Alkyl, alkoxy, alkylamino, alkenyl, alkynyl, carbocykyl, heterocyclyl, aryl, or heteroaryl is one or more R u It may also be replaced with F 3 CR F3 , N, or NR F3’ And, R F3 These are hydrogen, halogen, -CN, -NO2, -OH, -NH2, C 1-6 Alkyl, C 1-6 Alkoxy, C 1-6 Alkylamino, C 2-6 Alkenil, C 2-6 Alkinyl, C 3-12 Carbocyclyl, 3-12 member heterocyclyl, C 6-10Aryl, 5-10 member heteroaryl, -SR b -S(=O)R a -S(=O)2R a -S(=O)2OR b -S(=O)2NR c R d , -NR c S(=O)2R a , -NR c S(=O)R a , -NR c S(=O)2OR b , -NR c S(=O)2NR c R d , -NR b C(=O)NR c R d , -NR b C(=O)R a , -NR b C(=O)OR b -OS(=O)2R a -OS(=O)2OR b -OS(=O)2NR c R d -OC(=O)R a , -OC(=O)OR b -OC(=O)NR c R d -C(=O)R a , -C(=O)OR b , or -C(=O)NR c R d Alkyl, alkoxy, alkylamino, alkenyl, alkynyl, carbocykyl, heterocyclyl, aryl, or heteroaryl is one or more R u It may also be replaced with R F3’ is hydrogen, C 1-6 Alkyl, C 2-6 Alkenil, C 2-6 Alkinyl, C 3-12 Carbocyclyl, 3-12 member heterocyclyl, C 6-10 Aryl, 5-10 member heteroaryl, -S(=O)2R a -S(=O)2OR b -S(=O)2NR c Rd -C(=O)R a , -C(=O)OR b , or -C(=O)NR c R d Alkyl, alkenyl, alkynyl, carbocykyl, heterocyclyl, aryl, or heteroaryl is one or more R u It may also be replaced with R F4 is -C(=O)NR 3a R 3b , or one or more R u It is a 5-6 member heteroaryl which may be substituted with R 3a and R 3b These are, independently, hydrogen and C 1-6 Alkyl, C 2-6 Alkenil, C 2-6 Alkinyl, C 3-12 Carbocyclyl, 3-12 member heterocyclyl, C 6-10 Aryl, 5-10 member heteroaryl, -S(=O)2R a -S(=O)2OR b -S(=O)2NR c R d -C(=O)R a , -C(=O)OR b , or -C(=O)NR c R d Alkyl, alkenyl, alkynyl, carbocykyl, heterocyclyl, aryl, or heteroaryl is one or more R u It may also be replaced with R 3a and R 3b These, together with the nitrogen atoms to which they are bonded, form a 3-12 membered heterocycle or a 5-10 membered heteroaryl, and the heterocycle or heteroaryl contains one or more R u (May be replaced by) ii) Formula I-3-ii TIFF2026521988000089.tif28128 (in the formula, G 1 teeth, TIFF2026521988000090.tif8128, N, or CR G1 And, G 2 teeth, TIFF2026521988000091.tif8128, N, or CR G2 And, G 3 teeth, TIFF2026521988000092.tif8128, N, or CR G3 And, TIFF2026521988000093.tif8128 shows adhesion to L, R G1 , R G2 , R G3 , and R G4 These are independently hydrogen, halogen, -CN, -NO2, -OH, -NH2, C 1-6 Alkyl, C 1-6 Alkoxy, C 1-6 Alkylamino, C 2-6 Alkenil, C 2-6 Alkinyl, C 3-12 Carbocyclyl, 3-12 member heterocyclyl, C 6-10 Aryl, 5-10 member heteroaryl, -SR b -S(=O)R a -S(=O)2R a -S(=O)2OR b -S(=O)2NR c R d , -NR c S(=O)2R a , -NR c S(=O)R a , -NR c S(=O)2OR b , -NR c S(=O)2NR c R d , -NR b C(=O)NR c R d , -NR b C(=O)R a , -NR b C(=O)OR b -OS(=O)2R a-OS(=O)2OR b -OS(=O)2NR c R d -OC(=O)R a , -OC(=O)OR b -OC(=O)NR c R d -C(=O)R a , -C(=O)OR b , or -C(=O)NR c R d Alkyl, alkoxy, alkylamino, alkenyl, alkynyl, carbocykyl, heterocyclyl, aryl, or heteroaryl is one or more R u It may also be replaced with H 1 C(R H1 )2, NR H1’ , or O, H 2 C(R H2 )2, NR H2’ , or O, R H1 and R H2 Each occurrence is independently of hydrogen, halogen, -CN, -NO2, -OH, -NH2, C 1-6 Alkyl, C 1-6 Alkoxy, C 1-6 Alkylamino, C 2-6 Alkenil, C 2-6 Alkinyl, C 3-12 Carbocyclyl, 3-12 member heterocyclyl, C 6-10 The aryl or 5-10 membered heteroaryl is an alkyl, alkoxy, alkylamino, alkenyl, alkynyl, carbocykrill, heterocyclyl, aryl, or heteroaryl, which has one or more R u Is it okay if it is replaced with, or Two R's H1 or two R's H2 Together with the carbon atoms to which they are bonded, C 3-6 It forms a carbocyclic ring or a 3- to 6-membered heterocyclic ring, and the carbocyclic ring or heterocyclic ring has one or more R u It may also be replaced with R H1’and R H2’ Hydrogen and C are independent of each other. 1-6 Alkyl, C 3-6 Carbocyclyl, 3-6 member heterocyclyl, -S(=O)2R a -S(=O)2OR b -S(=O)2NR c R d -C(=O)R a , -C(=O)OR b , or -C(=O)NR c R d And alkyl, carbocykryl, or heterocyclyl is one or more R u (May be replaced by) iii) Formula I-3-iii TIFF2026521988000094.tif28128 (in the formula, TIFF2026521988000095.tif8128 shows adhesion to L, I 1 C(R I1 )2, NR I1’ , or O, I 2 C(R I2 )2, NR I2’ , or O, R I1 and R I2 Each occurrence is independently of hydrogen, halogen, -CN, -NO2, -OH, -NH2, C 1-6 Alkyl, C 1-6 Alkoxy, C 1-6 Alkylamino, C 2-6 Alkenil, C 2-6 Alkinyl, C 3-12 Carbocyclyl, 3-12 member heterocyclyl, C 6-10 The aryl or 5-10 membered heteroaryl is an alkyl, alkoxy, alkylamino, alkenyl, alkynyl, carbocykrill, heterocyclyl, aryl, or heteroaryl, which has one or more R u Is it okay if it is replaced with, or Two R's I1 or two R's I2 Together with the carbon atoms to which they are bonded, C3-6 It forms a carbocyclic ring or a 3- to 6-membered heterocyclic ring, and the carbocyclic ring or heterocyclic ring has one or more R u It may also be replaced with R I1’ and R I2’ Hydrogen and C are independent of each other. 1-6 Alkyl, C 3-6 Carbocyclyl, 3-6 member heterocyclyl, -S(=O)2R a -S(=O)2OR b -S(=O)2NR c R d -C(=O)R a , -C(=O)OR b , or -C(=O)NR c R d And alkyl, carbocykryl, or heterocyclyl is one or more R u It may also be replaced with Each R I These are independently oxo, halogen, -CN, -NO2, -OH, -NH2, C 1-6 Alkyl, C 1-6 Alkoxy, C 1-6 Alkylamino, C 2-6 Alkenil, C 2-6 Alkinyl, C 3-12 Carbocyclyl, 3-12 member heterocyclyl, C 6-10 Aryl, 5-10 member heteroaryl, -SR b -S(=O)R a -S(=O)2R a -S(=O)2OR b -S(=O)2NR c R d , -NR c S(=O)2R a , -NR c S(=O)R a , -NR c S(=O)2OR b , -NR c S(=O)2NR c R d , -NR b C(=O)NR c R d , -NR b C(=O)R a, -NR b C(=O)OR b -OS(=O)2R a -OS(=O)2OR b -OS(=O)2NR c R d -OC(=O)R a , -OC(=O)OR b -OC(=O)NR c R d -C(=O)R a , -C(=O)OR b , or -C(=O)NR c R d Alkyl, alkoxy, alkylamino, alkenyl, alkynyl, carbocykyl, heterocyclyl, aryl, or heteroaryl is one or more R u It may also be replaced with i is an integer selected from 0 to 4. J 1 is N or CR J1 And, J 2 is N or CR J2 And, R J1 , R J2 , and R J3 These are independently hydrogen, halogen, -CN, -NO2, -OH, -NH2, C 1-6 Alkyl, C 1-6 Alkoxy, C 1-6 Alkylamino, C 2-6 Alkenil, C 2-6 Alkinyl, C 3-12 Carbocyclyl, 3-12 member heterocyclyl, C 6-10 Aryl, 5-10 member heteroaryl, -SR b -S(=O)R a -S(=O)2R a -S(=O)2OR b -S(=O)2NR c R d , -NR c S(=O)2R a , -NR c S(=O)R a , -NR c S(=O)2ORb , -NR c S(=O)2NR c R d , -NR b C(=O)NR c R d , -NR b C(=O)R a , -NR b C(=O)OR b -OS(=O)2R a -OS(=O)2OR b -OS(=O)2NR c R d -OC(=O)R a , -OC(=O)OR b -OC(=O)NR c R d -C(=O)R a , -C(=O)OR b , or -C(=O)NR c R d Alkyl, alkoxy, alkylamino, alkenyl, alkynyl, carbocykyl, heterocyclyl, aryl, or heteroaryl is one or more R u It may also be replaced with iv) Equation I-3-iv TIFF2026521988000096.tif21128 (in the formula, M 1 is N or C, M 2 teeth, TIFF2026521988000097.tif10128, N, or CR M2 And, M 3 teeth, TIFF2026521988000098.tif10128, N, or CR M3 And, M 4 teeth, TIFF2026521988000099.tif10128, N, or CR M4 And, During the ceremony, TIFF2026521988000100.tif8128 shows adhesion to L, M1 M 2 M 3 , and M 4 At least one of them is N or The filename is TIFF2026521988000101.tif8128. R M2 , R M3 , and R M4 These are independently hydrogen, halogen, -CN, -NO2, -OH, -NH2, C 1-6 Alkyl, C 1-6 Alkoxy, C 1-6 Alkylamino, C 2-6 Alkenil, C 2-6 Alkinyl, C 3-12 Carbocyclyl, 3-12 member heterocyclyl, C 6-10 Aryl, 5-10 member heteroaryl, -SR b -S(=O)R a -S(=O)2R a -S(=O)2OR b -S(=O)2NR c R d , -NR c S(=O)2R a , -NR c S(=O)R a , -NR c S(=O)2OR b , -NR c S(=O)2NR c R d , -NR b C(=O)NR c R d , -NR b C(=O)R a , -NR b C(=O)OR b -OS(=O)2R a -OS(=O)2OR b -OS(=O)2NR c R d -OC(=O)R a , -OC(=O)OR b -OC(=O)NR c R d -C(=O)R a , -C(=O)OR b, or -C(=O)NR c R d Alkyl, alkoxy, alkylamino, alkenyl, alkynyl, carbocykyl, heterocyclyl, aryl, or heteroaryl is one or more R u It may also be replaced with R K’ is hydrogen, C 1-6 Alkyl, C 2-6 Alkenil, C 2-6 Alkinyl, C 3-12 Carbocyclyl, 3-12 member heterocyclyl, C 6-10 Aryl, 5-10 member heteroaryl, -S(=O)2R a -S(=O)2OR b -S(=O)2NR c R d -C(=O)R a , -C(=O)OR b , or -C(=O)NR c R d Alkyl, alkenyl, alkynyl, carbocykyl, heterocyclyl, aryl, or heteroaryl is one or more R u It may also be replaced with K 1 is -C(=O)- or -C(R K1 )2-, Each R K1 These are independently hydrogen, halogen, -CN, -NO2, -OH, -NH2, C 1-6 Alkyl, C 1-6 Alkoxy, C 1-6 Alkylamino, C 2-6 Alkenil, C 2-6 Alkinyl, C 3-12 Carbocyclyl, 3-12 member heterocyclyl, C 6-10 The aryl or 5-10 membered heteroaryl is an alkyl, alkoxy, alkylamino, alkenyl, alkynyl, carbocykrill, heterocyclyl, aryl, or heteroaryl, which has one or more R u It may also be replaced with Each R KThese are independently oxo, hydrogen, halogen, -CN, -NO2, -OH, -NH2, C 1-6 Alkyl, C 1-6 Alkoxy, C 1-6 Alkylamino, C 2-6 Alkenil, C 2-6 Alkinyl, C 3-12 Carbocyclyl, 3-12 member heterocyclyl, C 6-10 Aryl, 5-10 member heteroaryl, -SR b -S(=O)R a -S(=O)2R a -S(=O)2OR b -S(=O)2NR c R d , -NR c S(=O)2R a , -NR c S(=O)R a , -NR c S(=O)2OR b , -NR c S(=O)2NR c R d , -NR b C(=O)NR c R d , -NR b C(=O)R a , -NR b C(=O)OR b -OS(=O)2R a -OS(=O)2OR b -OS(=O)2NR c R d -OC(=O)R a , -OC(=O)OR b -OC(=O)NR c R d -C(=O)R a , -C(=O)OR b , or -C(=O)NR c R d Alkyl, alkoxy, alkylamino, alkenyl, alkynyl, carbocykyl, heterocyclyl, aryl, or heteroaryl is one or more R u It may also be replaced with k is an integer selected from 0 to 4. v) Equation I-3-v TIFF2026521988000102.tif24128 (in the formula, P 1 teeth, TIFF2026521988000103.tif10128, N, or CR P1 And, P 2 teeth, TIFF2026521988000104.tif10128, N, or CR P2 And, TIFF2026521988000105.tif8128 shows adhesion to L, Each R N These are independently oxo, halogen, -CN, -NO2, -OH, -NH2, C 1-6 Alkyl, C 1-6 Alkoxy, C 1-6 Alkylamino, C 2-6 Alkenil, C 2-6 Alkinyl, C 3-12 Carbocyclyl, 3-12 member heterocyclyl, C 6-10 Aryl, 5-10 member heteroaryl, -SR b -S(=O)R a -S(=O)2R a -S(=O)2OR b -S(=O)2NR c R d , -NR c S(=O)2R a , -NR c S(=O)R a , -NR c S(=O)2OR b , -NR c S(=O)2NR c R d , -NR b C(=O)NR c R d , -NR b C(=O)R a , -NR b C(=O)OR b -OS(=O)2R a -OS(=O)2ORb -OS(=O)2NR c R d -OC(=O)R a , -OC(=O)OR b -OC(=O)NR c R d -C(=O)R a , -C(=O)OR b , or -C(=O)NR c R d Alkyl, alkoxy, alkylamino, alkenyl, alkynyl, carbocykyl, heterocyclyl, aryl, or heteroaryl is one or more R u It may also be replaced with n is an integer selected from 0 to 6. R P1 , R P2 , and R P3 These are independently hydrogen, halogen, -CN, -NO2, -OH, -NH2, C 1-6 Alkyl, C 1-6 Alkoxy, C 1-6 Alkylamino, C 2-6 Alkenil, C 2-6 Alkinyl, C 3-12 Carbocyclyl, 3-12 member heterocyclyl, C 6-10 Aryl, 5-10 member heteroaryl, -SR b -S(=O)R a -S(=O)2R a -S(=O)2OR b -S(=O)2NR c R d , -NR c S(=O)2R a , -NR c S(=O)R a , -NR c S(=O)2OR b , -NR c S(=O)2NR c R d , -NR b C(=O)NR c R d , -NR b C(=O)R a , -NR b C(=O)ORb -OS(=O)2R a -OS(=O)2OR b -OS(=O)2NR c R d -OC(=O)R a , -OC(=O)OR b -OC(=O)NR c R d -C(=O)R a , -C(=O)OR b , or -C(=O)NR c R d Alkyl, alkoxy, alkylamino, alkenyl, alkynyl, carbocykyl, heterocyclyl, aryl, or heteroaryl is one or more R u It may also be replaced with, and R 4 -OH, -NH2, C 1-6 Alkyl, C 1-6 Alkoxy, C 1-6 Alkylamino, C 2-6 Alkenil, C 2-6 Alkinyl, C 3-12 Carbocyclyl, 3-12 member heterocyclyl, C 6-10 The aryl or 5-10 membered heteroaryl is an alkyl, alkoxy, alkylamino, alkenyl, alkynyl, carbocykrill, heterocyclyl, aryl, or heteroaryl, which has one or more R u (May be replaced by) or vi) Formula I-3-vi TIFF2026521988000106.tif21128 (in the formula, Q 1 , NR Q1’ , C(R Q1 )2, or O, R Q1’ is hydrogen, C 1-6 Alkyl, C 2-6 Alkenil, C 2-6 Alkinyl, C 3-12 Carbocyclyl, 3-12 member heterocyclyl, C 6-10 Aryl, 5-10 member heteroaryl, -S(=O)2Ra -S(=O)2OR b -S(=O)2NR c R d -C(=O)R a , -C(=O)OR b , or -C(=O)NR c R d Alkyl, alkenyl, alkynyl, carbocykyl, heterocyclyl, aryl, or heteroaryl is one or more R u It may also be replaced with Each R Q1 These are independently hydrogen, halogen, -CN, -NO2, -OH, -NH2, C 1-6 Alkyl, C 1-6 Alkoxy, C 1-6 Alkylamino, C 2-6 Alkenil, C 2-6 Alkinyl, C 3-12 Carbocyclyl, 3-12 member heterocyclyl, C 6-10 The aryl or 5-10 membered heteroaryl is an alkyl, alkoxy, alkylamino, alkenyl, alkynyl, carbocykrill, heterocyclyl, aryl, or heteroaryl, which has one or more R u Is it okay if it is replaced with, or Two R's Q1 Together with the carbon atoms to which they are bonded, C 3-6 It forms a carbocyclic ring or a 3- to 6-membered heterocyclic ring, and the carbocyclic ring or heterocyclic ring has one or more R u It may also be replaced with If TIFF2026521988000107.tif1128 has a double bond, Q 2 is N or CR Q2 Q 3 is N or CR Q3 And, If TIFF2026521988000108.tif1128 is a single join, Q 2 is NR Q2’ , C(R Q2 )2, or O, Q 3 is NR Q3’ , C(R Q3 )2, or O, R Q2’ and R Q3’ These are, independently, hydrogen and C 1-6 Alkyl, C 2-6 Alkenil, C 2-6 Alkinyl, C 3-12 Carbocyclyl, 3-12 member heterocyclyl, C 6-10 Aryl, 5-10 member heteroaryl, -S(=O)2R a -S(=O)2OR b -S(=O)2NR c R d -C(=O)R a , -C(=O)OR b , or -C(=O)NR c R d Alkyl, alkenyl, alkynyl, carbocykyl, heterocyclyl, aryl, or heteroaryl is one or more R u It may also be replaced with R Q2 and R Q3 Each occurrence is independently of hydrogen, halogen, -CN, -NO2, -OH, -NH2, C 1-6 Alkyl, C 1-6 Alkoxy, C 1-6 Alkylamino, C 2-6 Alkenil, C 2-6 Alkinyl, C 3-12 Carbocyclyl, 3-12 member heterocyclyl, C 6-10 The aryl or 5-10 membered heteroaryl is an alkyl, alkoxy, alkylamino, alkenyl, alkynyl, carbocykrill, heterocyclyl, aryl, or heteroaryl, which has one or more R u Is it okay if it is replaced with, or Two R's Q2 or two R's Q3 Together with the carbon atoms to which they are bonded, C 3-6 It forms a carbocyclic ring or a 3- to 6-membered heterocyclic ring, and the carbocyclic ring or heterocyclic ring has one or more R u It may also be replaced with S 1 CR S1 or N, S2 teeth TIFF2026521988000109.tif8128,CR S2 , or N, S 3 teeth TIFF2026521988000110.tif8128,CR S3 , or N, S 4 teeth, TIFF2026521988000111.tif8128,CR S4 , or N, TIFF2026521988000112.tif8128 shows adhesion to L, and R S1 , R S2 , R S3 , and R S4 These are independently hydrogen, halogen, -CN, -NO2, -OH, -NH2, C 1-6 Alkyl, C 1-6 Alkoxy, C 1-6 Alkylamino, C 2-6 Alkenil, C 2-6 Alkinyl, C 3-12 Carbocyclyl, 3-12 member heterocyclyl, C 6-10 Aryl, 5-10 member heteroaryl, -SR b -S(=O)R a -S(=O)2R a -S(=O)2OR b -S(=O)2NR c R d , -NR c S(=O)2R a , -NR c S(=O)R a , -NR c S(=O)2OR b , -NR c S(=O)2NR c R d , -NR b C(=O)NR c R d , -NR b C(=O)R a , -NR b C(=O)ORb -OS(=O)2R a -OS(=O)2OR b -OS(=O)2NR c R d -OC(=O)R a , -OC(=O)OR b -OC(=O)NR c R d -C(=O)R a , -C(=O)OR b , or -C(=O)NR c R d Alkyl, alkoxy, alkylamino, alkenyl, alkynyl, carbocykyl, heterocyclyl, aryl, or heteroaryl is one or more R u (It may be replaced by) L is the expression in Equation I-2, TIFF2026521988000113.tif10128In formula, * indicates adhesion to C. Cy 1 teeth, The filename is TIFF2026521988000114.tif20128, and in the formula, TIFF2026521988000115.tif6128 shows adhesion to T, T 1 CR T1 or N, V 1 CR V1 or N, V 2 CR V2 or N, R T1 , R V1 , and R V2 These are independently hydrogen, halogen, -CN, -NO2, -OH, -NH2, C 1-6 Alkyl, C 1-6 Alkoxy, C 1-6 Alkylamino, C 3-4 Carbocyclyl, or 3-4 membered heterocyclyl, wherein alkyl, alkoxy, alkylamino, carbocyclyl, or heterocyclyl is one or more R uIt may also be replaced with Each R T These are, independently, halogen, -CN, -NO2, -OH, -NH2, C 1-6 Alkyl, C 1-6 Alkoxy, C 1-6 Alkylamino, C 3-4 Carbocyclyl, or 3-4 membered heterocyclyl, wherein alkyl, alkoxy, alkylamino, carbocyclyl, or heterocyclyl is one or more R u It may also be replaced with t is an integer selected from 0 to 6, as long as the valence allows, or Cy 1 teeth, TIFF2026521988000116.tif19128, and in the formula, Y 1 is N or CR Y1 And, TIFF2026521988000117.tif6128 shows adhesion to T, R Y1 These are hydrogen, halogen, -CN, -NO2, -OH, -NH2, C 1-6 Alkyl, C 1-6 Alkoxy, C 1-6 Alkylamino, C 3-4 Carbocyclyl, or 3-4 membered heterocyclyl, wherein alkyl, alkoxy, alkylamino, carbocyclyl, or heterocyclyl is one or more R u It may also be replaced with Y 2 C(R Y2 )2, O, or N(R Y2’ ) and Each R Y2 These are independently hydrogen, halogen, -CN, -NO2, -OH, -NH2, C 1-6 Alkyl, C 1-6 Alkoxy, C 1-6 Alkylamino, C 3-4 Carbocyclyl, or 3-4 membered heterocyclyl, wherein alkyl, alkoxy, alkylamino, carbocyclyl, or heterocyclyl is one or more R uIt may also be replaced with R Y2’ is hydrogen, C 1-6 Alkyl, C 3-4 Carbocyclyl, 3-4 member heterocyclyl, -S(=O)2R a -S(=O)2OR b -S(=O)2NR c R d -C(=O)R a , -C(=O)OR b , or -C(=O)NR c R d And alkyl, carbocykryl, or heterocyclyl is one or more R u It may also be replaced with Z 1 CR Z1 or N, R Z1 These are hydrogen, halogen, -CN, -NO2, -OH, -NH2, C 1-6 Alkyl, C 1-6 Alkoxy, C 1-6 Alkylamino, C 3-4 Carbocyclyl, or 3-4 membered heterocyclyl, wherein alkyl, alkoxy, alkylamino, carbocyclyl, or heterocyclyl is one or more R u It may also be replaced with Each R Z These are independently oxo, halogen, -CN, -NO2, -OH, -NH2, C 1-6 Alkyl, C 1-6 Alkoxy, C 1-6 Alkylamino, C 3-4 Carbocyclyl, or 3-4 membered heterocyclyl, wherein alkyl, alkoxy, alkylamino, carbocyclyl, or heterocyclyl is one or more R u It may also be replaced with z is an integer selected from 0 to 6, as long as the valence allows. Here, R Z It may exist in either ring Y or ring Z. Cy 2 is one or more R uIt is a 5-6 member heteroarylene which may be substituted with L 3 These are E-ethenylene, ethynylene, C6 arylene, or 5-6 member heteroarylene, and E-ethenylene, arylene, or heteroarylene contains one or more R u It may also be replaced with Here, Each R u These are independently oxo, halogen, -CN, -NO2, -OH, -NH2, C 1-6 Alkyl, C 1-6 Alkoxy, C 1-6 Alkylamino, C 3-4 Carbocyclyl, or 3-4 membered heterocyclyl, Each R a C 1-6 Alkyl, C 3-6 Carbocyclyl, or 3-6 membered heterocyclyl, Each R b These are, independently, hydrogen and C 1-6 Alkyl, C 3-6 Carbocyclyl, or 3-6 membered heterocyclyl, R c and R d Each of them independently consists of hydrogen and C. 1-6 Alkyl, C 3-6 It is either a carbocyclyl or a 3-6 member heterocyclyl, or R c and R d These, together with the nitrogen atom to which they are bonded, form a 3-6 membered heterocycline. R a , R b , R c , and R d Each occurrence of is independent and is associated with one or more R z It may also be replaced with Each R z These are independently oxo, halogen, -CN, -NO2, -OH, -NH2, C 1-6 Alkyl, C 1-6 Alkoxy, C 1-6 Alkylamino, C 3-6They are carbocyclyls, or 3- to 6-membered heterocyclyls.

[0012] In certain embodiments, this disclosure relates to compounds of formula IA: We provide TIFF2026521988000118.tif52128 or its pharmaceutically acceptable salts, solvates, or stereoisomers, in which, G 3 is N or CH, R G4 C 1-6 Alkyl or 3-12 membered heterocyclyl, Cy 1 teeth, The filename is TIFF2026521988000119.tif22128. During the ceremony, TIFF2026521988000120.tif6128 shows adhesion to ring G, Z 1 CR Z1 or N, R Z1 It is a halogen, Cy 2 teeth, TIFF2026521988000121.tif14128, and in the formula, TIFF2026521988000122.tif6128 is Cy 1 It shows adhesion to [the surface].

[0013] In certain embodiments, this disclosure relates to compounds of formula IB: We provide TIFF2026521988000123.tif69137 or its pharmaceutically acceptable salts, solvates, or stereoisomers, in which, S 1 is CH or N, S 3 is CH or N, R S2 C 1-6 They are alkyl or 3- to 12-membered heterocyclines.

[0014] In a particular embodiment, the compound of formula I is It is not TIFF2026521988000124.tif35156.

[0015] In a particular embodiment, the compound of formula I is It is not TIFF2026521988000125.tif106135.

[0016] In a particular embodiment, C is the formula of formula I-1', TIFF2026521988000126.tif37128In formula, TIFF2026521988000127.tif8128 shows adhesion to L, B 1 CR B1 or N, B 3 CR B3 or N, B 4 CR B4 or N, B 5 CR B5 or N, B 6 is C or N, R B1 , R B3 , R B4 , and R B5 These are independently oxo, hydrogen, halogen, -CN, -NO2, -OH, -NH2, C 1-6 Alkyl, C 1-6 Alkoxy, C 1-6 Alkylamino, C 3-4 Carbocyclyl, or 3-5 membered heterocyclyl, wherein alkyl, alkoxy, alkylamino, carbocyclyl, or heterocyclyl is one or more R u It may also be replaced with X is either nonexistent, or O, S, or NR. X And, R X is hydrogen, C 1-3 Alkyl, C 3-4 Carbocyclyl, or 3-4 membered heterocyclyl, RD1 is hydrogen, deuterium, or C 1-6 It is alkyl, Each R D These are, independently, halogen, -CN, -NO2, -OH, -NH2, C 1-6 Alkyl, C 1-6 Alkoxy, C 1-6 Alkylamino, C 3-4 Carbocyclyl, or 3-4 membered heterocyclyl, wherein alkyl, alkoxy, alkylamino, carbocyclyl, or heterocyclyl is one or more R u It may also be replaced with d is an integer between 0 and 6, as long as the valence allows. q is an integer between 0 and 2.

[0017] In a particular embodiment, C is the formula of formula I-1', TIFF2026521988000128.tif37128In formula, TIFF2026521988000129.tif8128 shows adhesion to L, B 1 CR B1 or N, B 3 CR B3 or N, B 4 CR B4 or N, B 5 CR B5 or N, B 6 is C or N, R B1 , R B3 , R B4 , and R B5 These are independently oxo, hydrogen, halogen, -CN, -NO2, -OH, -NH2, C 1-6 Alkyl, C 1-6 Alkoxy, C 1-6 Alkylamino, C 3-4 Carbocyclyl, or 3-4 membered heterocyclyl, wherein alkyl, alkoxy, alkylamino, carbocyclyl, or heterocyclyl is one or more Ru It may also be replaced with X is either nonexistent, O, or NR X And, R X is hydrogen, C 1-3 Alkyl, C 3-4 Carbocyclyl, or 3-4 membered heterocyclyl, R D1 is hydrogen, deuterium, or C 1-6 It is alkyl, Each R D These are, independently, halogen, -CN, -NO2, -OH, -NH2, C 1-6 Alkyl, C 1-6 Alkoxy, C 1-6 Alkylamino, C 3-4 Carbocyclyl, or 3-4 membered heterocyclyl, wherein alkyl, alkoxy, alkylamino, carbocyclyl, or heterocyclyl is one or more R u It may also be replaced with d is an integer between 0 and 6, as long as the valence allows. q is an integer between 0 and 2.

[0018] In a particular embodiment, C is the formula of formula I-1', where, B 1 CR B1 or N, B 3 CR B3 or N, B 4 CR B4 or N, B 5 CR B5 or N, B 6 is C or N, R B1 is hydrogen or halogen, R B3 is hydrogen, halogen, -CN, or C 1-6 It is alkyl, R B4 Hydrogen, halogen, -CN, C 1-6 Alkyl, C1-6 Alkylamino or 3-4 membered heterocyclyl, R B5 C may be substituted with oxo, hydrogen, halogen, or one or more halogens. 1-6 C may be substituted with alkyl or one or more halogens. 1-6 Alkoxy, or C 1-6 It is an alkylamino compound. X is either nonexistent, O, or NR X And, R X is hydrogen or C 1-3 It is alkyl, R D1 It is hydrogen, d is 0, q is 1.

[0019] In a particular embodiment, C is the formula of formula I-1, TIFF2026521988000130.tif33128 (in the formula, B 1 CR B1 or N, B 3 CR B3 or N, B 4 CR B4 or N, B 5 CR B5 or N, R B1 , R B3 , R B4 , and R B5 These are independently hydrogen, halogen, -CN, -NO2, -OH, -NH2, C 1-6 Alkyl, C 1-6 Alkoxy, C 1-6 Alkylamino, C 3-4 Carbocyclyl, or 3-4 membered heterocyclyl, wherein alkyl, alkoxy, alkylamino, carbocyclyl, or heterocyclyl is one or more R u It may also be replaced with X is either nonexistent, O, or NR XAnd, R X is hydrogen, C 1-3 Alkyl, C 3-4 It is either a carbocyclyl or a 3-4 member heterocyclyl, or X is NR X and B 5 CR B5 If so, R X and R B5 These, together with the atoms to which they are bonded, form a 5-membered heteroaryl compound. R D1 is hydrogen, deuterium, or C 1-6 It is alkyl, Each R D These are, independently, halogen, -CN, -NO2, -OH, -NH2, C 1-6 Alkyl, C 1-6 Alkoxy, C 1-6 Alkylamino, C 3-4 Carbocyclyl, or 3-4 membered heterocyclyl, wherein alkyl, alkoxy, alkylamino, carbocyclyl, or heterocyclyl is one or more R u It may also be replaced with d is an integer between 0 and 6, as long as the valence allows. q is an integer between 0 and 2.

[0020] In a particular embodiment, C is the formula of formula I-1', TIFF2026521988000131.tif40128 formula, TIFF2026521988000132.tif8128 shows adhesion to L, B 1 CR B1 And, B 3 CR B3 And, B 4 CR B4 And, B 5 CR B5 And, B 6 C is, RB1 , R B3 , R B4 , and R B5 It is, independently, hydrogen, X is NR X And, R X It is hydrogen, R D1 It is hydrogen, d is 0, q is 1.

[0021] In certain embodiments, X is either absent or O, S, or NR X In certain embodiments, X is O. In certain embodiments, X is S. In certain embodiments, X is NR X That is the case.

[0022] In certain embodiments, X is absent, O, or NR X In certain embodiments, X is either absent or NH. In certain embodiments, X is absent.

[0023] In a particular embodiment, R X is hydrogen, C 1-3 Alkyl (e.g., methyl (C1), ethyl (C2), n-propyl (C3), or i-propyl (C3)), C 3-4 These are carbocyclyls (e.g., cyclopropyl (C3), cyclopropenyl (C3), cyclobutyl (C4), or cyclobutenyl (C4)) or 3-4 membered heterocyclyls (e.g., heterocyclyls containing one 3-4 membered ring and one heteroatom selected from N, O, and S).

[0024] In certain embodiments, C is an expression of formula I-1'-X or I-1'-Y. TIFF2026521988000133.tif40130

[0025] In certain embodiments, C is the formula I-1-i, I-1-ii, or I-1-iii. TIFF2026521988000134.tif30150

[0026] In a particular embodiment, C is the expression of formula I-1-i. TIFF2026521988000135.tif30128

[0027] In certain embodiments, C is an expression of formula I-1-i-1', I-1-i-2', I-1-i-3, I-1-ii-1, I-1-ii-2, I-1-ii-3, I-1-iii-1, I-1-iii-2, or I-1-iii-3. TIFF2026521988000136.tif188137

[0028] In certain embodiments, C is the formula I-1-i-1 or I-1-i-2. TIFF2026521988000137.tif33128

[0029] In a particular embodiment, B 1 CR B1 Or N. In a particular embodiment, B 1 CR B1 In a particular embodiment, B 1 It is N.

[0030] In a particular embodiment, B 3 CR B3 Or N. In a particular embodiment, B 3 CR B3 In a particular embodiment, B 3 It is N.

[0031] In a particular embodiment, B 4 CR B4 Or N. In a particular embodiment, B 4 CR B4 In a particular embodiment, B 4 It is N.

[0032] In a particular embodiment, B 5 CRB5 Or N. In a particular embodiment, B 5 CR B5 In a particular embodiment, B 5 It is N.

[0033] In a particular embodiment, B 6 is C or N. In certain embodiments, B 6 C is C. In certain embodiments, B 6 It is N.

[0034] In a particular embodiment, B 1 B 3 B 4 , and B 5 None of them are N.

[0035] In a particular embodiment, B 1 and B 5 One of them is N, and B 1 and B 5 The other of these is CR B1 or CR B5 That is the case.

[0036] In a particular embodiment, R B1 , R B3 , R B4 , and R B5 These are independently oxo, hydrogen, halogen (e.g., -F, -Cl, -Br, or -I), -CN, -NO2, -OH, -NH2, C 1-6 Alkyl (e.g., methyl (C1), ethyl (C2), n-propyl (C3), i-propyl (C3), n-butyl (C4), i-butyl (C4), s-butyl (C4), t-butyl (C4), pentyl (C5), or hexyl (C6)), C 1-6 Alkoxy (e.g., methoxy (C1), ethoxy (C2), propoxy (C3), i-propoxy (C3), n-butoxy (C4), i-butoxy (C4), s-butoxy (C4), t-butoxy (C4), pentoxy (C5), or hexoxy (C6)), C 1-6Alkylaminos (e.g., dimethylamino, diethylamino, di-n-propylamino, di-i-propylamino, di-n-butylamino, di-i-butylamino, di-s-butylamino, di-t-butylamino, dipentylamino, dihexylamino, methylethylamino, methyl-n-propylamino, methyl-i-propylamino, methyl-n-butylamino, methyl-i-butylamino, methyl-s-butylamino, methyl-t-butylamino, methylpentylamino, methylhexylamino, ethyl-n-propylamino, ethyl-i-propylamino, ethyl-n-butylamino) (No, ethyl-s-butylamino, ethyl-i-butylamino, ethyl-t-butylamino, ethylpentylamino, ethylhexylamino, propyl-n-butylamino, propyl-i-butylamino, propyl-s-butylamino, propyl-t-butylamino, propylpentyrylamino, propylhexylamino, n-butylpentylamino, i-butylpentylamino, s-butylpentylamino, t-butylpentylamino, n-butylhexylamino, i-butylhexylamino, s-butylhexylamino, t-butylpentylamino, n-butylhexylamino, i-butylhexylamino, s-butylhexylamino, t-butylhexylamino, or pentylhexylamino), C 3-4 Carbocyclyl (e.g., cyclopropyl (C3), cyclopropenyl (C3), cyclobutyl (C4), or cyclobutenyl (C4)) or 3- to 5-membered heterocyclyl (e.g., a heterocyclyl containing one 3- to 5-membered ring and at least one heteroatom independently selected from N, O, and S), wherein alkyl, alkoxy, alkylamino, carbocyrill, or heterocyclyl contains one or more R u It may be replaced with .

[0037] In a particular embodiment, R B1 , R B3 , and R B4 These are independently oxo, hydrogen, halogen (e.g., -F, -Cl, -Br, or -I), -CN, -NO2, -OH, -NH2, C 1-6Alkyl (e.g., methyl (C1), ethyl (C2), n-propyl (C3), i-propyl (C3), n-butyl (C4), i-butyl (C4), s-butyl (C4), t-butyl (C4), pentyl (C5), or hexyl (C6)), C 1-6 Alkoxy (e.g., methoxy (C1), ethoxy (C2), propoxy (C3), i-propoxy (C3), n-butoxy (C4), i-butoxy (C4), s-butoxy (C4), t-butoxy (C4), pentoxy (C5), or hexoxy (C6)), C 1-6 Alkylaminos (e.g., dimethylamino, diethylamino, di-n-propylamino, di-i-propylamino, di-n-butylamino, di-i-butylamino, di-s-butylamino, di-t-butylamino, dipentylamino, dihexylamino, methylethylamino, methyl-n-propylamino, methyl-i-propylamino, methyl-n-butylamino, methyl-i-butylamino, methyl-s-butylamino, methyl-t-butylamino, methylpentylamino, methylhexylamino, ethyl-n-propylamino, ethyl-i-propylamino, ethyl-n-butylamino) (No, ethyl-s-butylamino, ethyl-i-butylamino, ethyl-t-butylamino, ethylpentylamino, ethylhexylamino, propyl-n-butylamino, propyl-i-butylamino, propyl-s-butylamino, propyl-t-butylamino, propylpentyrylamino, propylhexylamino, n-butylpentylamino, i-butylpentylamino, s-butylpentylamino, t-butylpentylamino, n-butylhexylamino, i-butylhexylamino, s-butylhexylamino, t-butylpentylamino, n-butylhexylamino, i-butylhexylamino, s-butylhexylamino, t-butylhexylamino, or pentylhexylamino), C 3-4 Carbocyclyl (e.g., cyclopropyl (C3), cyclopropenyl (C3), cyclobutyl (C4), or cyclobutenyl (C4)) or 3- to 5-membered heterocyclyl (e.g., a heterocyclyl containing one 3- to 5-membered ring and at least one heteroatom independently selected from N, O, and S), wherein alkyl, alkoxy, alkylamino, carbocyrill, or heterocyclyl contains one or more R uIt may be replaced with .

[0038] In a particular embodiment, R B3 , R B4 , and R B5 These are independently oxo, hydrogen, halogen (e.g., -F, -Cl, -Br, or -I), -CN, -NO2, -OH, -NH2, C 1-6 Alkyl (e.g., methyl (C1), ethyl (C2), n-propyl (C3), i-propyl (C3), n-butyl (C4), i-butyl (C4), s-butyl (C4), t-butyl (C4), pentyl (C5), or hexyl (C6)), C 1-6 Alkoxy (e.g., methoxy (C1), ethoxy (C2), propoxy (C3), i-propoxy (C3), n-butoxy (C4), i-butoxy (C4), s-butoxy (C4), t-butoxy (C4), pentoxy (C5), or hexoxy (C6)), C 1-6 Alkylaminos (e.g., dimethylamino, diethylamino, di-n-propylamino, di-i-propylamino, di-n-butylamino, di-i-butylamino, di-s-butylamino, di-t-butylamino, dipentylamino, dihexylamino, methylethylamino, methyl-n-propylamino, methyl-i-propylamino, methyl-n-butylamino, methyl-i-butylamino, methyl-s-butylamino, methyl-t-butylamino, methylpentylamino, methylhexylamino, ethyl-n-propylamino, ethyl-i-propylamino, ethyl-n-butylamino) (No, ethyl-s-butylamino, ethyl-i-butylamino, ethyl-t-butylamino, ethylpentylamino, ethylhexylamino, propyl-n-butylamino, propyl-i-butylamino, propyl-s-butylamino, propyl-t-butylamino, propylpentyrylamino, propylhexylamino, n-butylpentylamino, i-butylpentylamino, s-butylpentylamino, t-butylpentylamino, n-butylhexylamino, i-butylhexylamino, s-butylhexylamino, t-butylpentylamino, n-butylhexylamino, i-butylhexylamino, s-butylhexylamino, t-butylhexylamino, or pentylhexylamino), C 3-4Carbocyclyl (e.g., cyclopropyl (C3), cyclopropenyl (C3), cyclobutyl (C4), or cyclobutenyl (C4)) or 3- to 5-membered heterocyclyl (e.g., a heterocyclyl containing one 3- to 5-membered ring and at least one heteroatom independently selected from N, O, and S), wherein alkyl, alkoxy, alkylamino, carbocyrill, or heterocyclyl contains one or more R u It may be replaced with .

[0039] In a particular embodiment, R B1 , R B3 , R B4 , and R B5 , R B1 , R B3 , and R B4 , or R B3 , R B4 , and R B5 These are independently oxo, hydrogen, halogen (e.g., -F, -Cl, -Br, or -I), -CN, -NO2, -OH, -NH2, C 1-6 Alkyl (e.g., methyl (C1), ethyl (C2), n-propyl (C3), i-propyl (C3), n-butyl (C4), i-butyl (C4), s-butyl (C4), t-butyl (C4), pentyl (C5), or hexyl (C6)), C 1-6 Alkoxy (e.g., methoxy (C1), ethoxy (C2), propoxy (C3), i-propoxy (C3), n-butoxy (C4), i-butoxy (C4), s-butoxy (C4), t-butoxy (C4), pentoxy (C5), or hexoxy (C6)), C 1-6Alkylaminos (e.g., dimethylamino, diethylamino, di-n-propylamino, di-i-propylamino, di-n-butylamino, di-i-butylamino, di-s-butylamino, di-t-butylamino, dipentylamino, dihexylamino, methylethylamino, methyl-n-propylamino, methyl-i-propylamino, methyl-n-butylamino, methyl-i-butylamino, methyl-s-butylamino, methyl-t-butylamino, methylpentylamino, methylhexylamino, ethyl-n-propylamino, ethyl-i-propylamino, ethyl-n-butylamino) (No, ethyl-s-butylamino, ethyl-i-butylamino, ethyl-t-butylamino, ethylpentylamino, ethylhexylamino, propyl-n-butylamino, propyl-i-butylamino, propyl-s-butylamino, propyl-t-butylamino, propylpentyrylamino, propylhexylamino, n-butylpentylamino, i-butylpentylamino, s-butylpentylamino, t-butylpentylamino, n-butylhexylamino, i-butylhexylamino, s-butylhexylamino, t-butylpentylamino, n-butylhexylamino, i-butylhexylamino, s-butylhexylamino, t-butylhexylamino, or pentylhexylamino), C 3-4 Carbocyclyl (e.g., cyclopropyl (C3), cyclopropenyl (C3), cyclobutyl (C4), or cyclobutenyl (C4)) or 3-4 membered heterocyclyl (e.g., a heterocyclyl containing one 3-4 membered ring and one heteroatom selected from N, O, and S), wherein alkyl, alkoxy, alkylamino, carbocyclyl, or heterocyclyl contains one or more R u It may be replaced with .

[0040] In a particular embodiment, R B1 , R B3 , R B4 , and R B5 These are independently oxo, hydrogen, halogen, -CN, -NO2, -OH, -NH2, C 1-6 Alkyl, C 1-6 Alkoxy, C 1-6 Alkylamino, C 3-4 They are carbocyclyls, or 3- to 5-membered heterocyclyls.

[0041] In a particular embodiment, R B1 , R B3 , R B4 , and R B5 These are independently oxo, hydrogen, halogen, -CN, -NO2, -OH, -NH2, C 1-6 Alkyl, C 1-6 Alkoxy, C 1-6 Alkylamino, C 3-4 They are carbocyclyls or 3-4 membered heterocyclyls.

[0042] In a particular embodiment, R B1 , R B3 , R B4 , and R B5 These are independently oxo, hydrogen, halogen, and C 1-6 Alkyl, or C 1-6 It is an alkoxy.

[0043] In a particular embodiment, R B1 , R B3 , R B4 , and R B5 , R B1 , R B3 , and R B4 , or R B3 , R B4 , and R B5 These are independently oxo, hydrogen, halogen, -CN, -NO2, -OH, -NH2, C 1-6 Alkyl, C 1-6 Alkoxy, C 1-6 Alkylamino, C 3-4 The molecule is a carbocyclyl or a 3- to 5-membered heterocyclyl, and the alkyl, alkoxy, alkylamino, carbocyclyl, or heterocyclyl may be substituted with one or more halogens.

[0044] In a particular embodiment, R B1 , R B3 , R B4 , and R B5 These are independently oxo, hydrogen, halogen, -CN, -NO2, -OH, -NH2, C 1-6 Alkyl, C1-6 Alkoxy, C 1-6 Alkylamino, C 3-4 The molecule is a carbocyclyl or a 3- to 5-membered heterocyclyl, and the alkyl, alkoxy, alkylamino, carbocyclyl, or heterocyclyl may be substituted with one or more halogens.

[0045] In a particular embodiment, R B1 , R B3 , and R B4 These are independently oxo, hydrogen, halogen, -CN, -NO2, -OH, -NH2, C 1-6 Alkyl, C 1-6 Alkoxy, C 1-6 Alkylamino, C 3-4 The molecule is a carbocyclyl or a 3- to 5-membered heterocyclyl, and the alkyl, alkoxy, alkylamino, carbocyclyl, or heterocyclyl may be substituted with one or more halogens.

[0046] In a particular embodiment, R B3 , R B4 , and R B5 These are independently oxo, hydrogen, halogen, -CN, -NO2, -OH, -NH2, C 1-6 Alkyl, C 1-6 Alkoxy, C 1-6 Alkylamino, C 3-4 The molecule is a carbocyclyl or a 3- to 5-membered heterocyclyl, and the alkyl, alkoxy, alkylamino, carbocyclyl, or heterocyclyl may be substituted with one or more halogens.

[0047] In a particular embodiment, R B1 , R B3 , R B4 , and R B5 , R B1 , R B3 , and R B4 , or R B3 , R B4 , and R B5 These are independently oxo, hydrogen, halogen, -CN, -NO2, -OH, -NH2, C 1-6 Alkyl, C1-6 Alkoxy, C 1-6 Alkylamino, C 3-4 The molecule is a carbocyclyl or a 3-4 membered heterocyclyl, and the alkyl, alkoxy, alkylamino, carbocyclyl, or heterocyclyl may be substituted with one or more halogens.

[0048] In a particular embodiment, R B1 , R B3 , R B4 , and R B5 , R B1 , R B3 , and R B4 , or R B3 , R B4 , and R B5 These are independently oxo, hydrogen, halogen, -CN, -OH, and C 1-6 Alkyl, C 1-6 Haloalkyl, C 1-6 Alkoxy, or C 1-6 It is an alkylamino compound.

[0049] In a particular embodiment, R B1 , R B3 , R B4 , and R B5 , R B1 , R B3 , and R B4 , or R B3 , R B4 , and RB5 These are independently hydrogen, halogen, or C 1-6 It is alkyl.

[0050] In a particular embodiment, R D1 is hydrogen, deuterium, or C 1-6 Alkyl compounds (for example, methyl (C1), ethyl (C2), n-propyl (C3), i-propyl (C3), n-butyl (C4), i-butyl (C4), s-butyl (C4), t-butyl (C4), pentyl (C5), or hexyl (C6)).

[0051] In a particular embodiment, R D1 It is hydrogen.

[0052] In a specific method of operation, each R D These are independently oxo, hydrogen, halogen (e.g., -F, -Cl, -Br, or -I), -CN, -NO2, -OH, -NH2, C 1-6 Alkyl (e.g., methyl (C1), ethyl (C2), n-propyl (C3), i-propyl (C3), n-butyl (C4), i-butyl (C4), s-butyl (C4), t-butyl (C4), pentyl (C5), or hexyl (C6)), C 1-6 Alkoxy (e.g., methoxy (C1), ethoxy (C2), propoxy (C3), i-propoxy (C3), n-butoxy (C4), i-butoxy (C4), s-butoxy (C4), t-butoxy (C4), pentoxy (C5), or hexoxy (C6)), C 1-6 Alkylaminos (e.g., dimethylamino, diethylamino, di-n-propylamino, di-i-propylamino, di-n-butylamino, di-i-butylamino, di-s-butylamino, di-t-butylamino, dipentylamino, dihexylamino, methylethylamino, methyl-n-propylamino, methyl-i-propylamino, methyl-n-butylamino, methyl-i-butylamino, methyl-s-butylamino, methyl-t-butylamino, methylpentylamino, methylhexylamino, ethyl-n-propylamino, ethyl-i-propylamino, ethyl-n-butylamino) (No, ethyl-s-butylamino, ethyl-i-butylamino, ethyl-t-butylamino, ethylpentylamino, ethylhexylamino, propyl-n-butylamino, propyl-i-butylamino, propyl-s-butylamino, propyl-t-butylamino, propylpentyrylamino, propylhexylamino, n-butylpentylamino, i-butylpentylamino, s-butylpentylamino, t-butylpentylamino, n-butylhexylamino, i-butylhexylamino, s-butylhexylamino, t-butylpentylamino, n-butylhexylamino, i-butylhexylamino, s-butylhexylamino, t-butylhexylamino, or pentylhexylamino), C 3-4Carbocyclyl (e.g., cyclopropyl (C3), cyclopropenyl (C3), cyclobutyl (C4), or cyclobutenyl (C4)) or 3-4 membered heterocyclyl (e.g., a heterocyclyl containing one 3-4 membered ring and one heteroatom selected from N, O, and S), and alkyl, alkoxy, alkylamino, carbocyclyl, or heterocyclyl are

[0053] In certain embodiments, d is an integer between 0 and 6, as far as the valence allows. In certain embodiments, d is 0. In certain embodiments, d is 1. In certain embodiments, d is 2. In certain embodiments, d is 3, as far as the valence allows. In certain embodiments, d is 4, as far as the valence allows. In certain embodiments, d is 5, as far as the valence allows. In certain embodiments, d is 6, as far as the valence allows.

[0054] In certain embodiments, d is 0.

[0055] In certain embodiments, q is an integer between 0 and 2. In certain embodiments, q is 0. In certain embodiments, q is 1. In certain embodiments, q is 2.

[0056] In a particular embodiment, q is 1.

[0057] In a particular embodiment, C is Selected from the group consisting of TIFF2026521988000138.tif244143.

[0058] In a particular embodiment, C is The filename is TIFF2026521988000139.tif14128.

[0059] In a particular embodiment, T is given by formula I-3-i, TIFF2026521988000140.tif25128In formula, TIFF2026521988000141.tif8128,CRE1 , or N, E 2 teeth, TIFF2026521988000142.tif8128,CR E2 , or N, E 3 teeth, TIFF2026521988000143.tif8128,CR E3 , or N, TIFF2026521988000144.tif8128 shows adhesion to L, R E1 , R E2 , R E3 , and R E4 These are independently hydrogen, halogen, -CN, -NO2, -OH, -NH2, C 1-6 Alkyl, C 1-6 Alkoxy, C 1-6 Alkylamino, C 2-6 Alkenil, C 2-6 Alkinyl, C 3-12 Carbocyclyl, 3-12 member heterocyclyl, C 6-10 Aryl, 5-10 member heteroaryl, -SR b -S(=O)R a -S(=O)2R a -S(=O)2OR b -S(=O)2NR c R d , -NR c S(=O)2R a , -NR c S(=O)R a , -NR c S(=O)2OR b , -NR c S(=O)2NR c R d , -NR b C(=O)NR c R d , -NR b C(=O)R a , -NR b C(=O)OR b -OS(=O)2R a -OS(=O)2OR b-OS(=O)2NR c R d -OC(=O)R a , -OC(=O)OR b -OC(=O)NR c R d -C(=O)R a , -C(=O)OR b , or -C(=O)NR c R d Alkyl, alkoxy, alkylamino, alkenyl, alkynyl, carbocykyl, heterocyclyl, aryl, or heteroaryl is one or more R u It may also be replaced with F 1 is C or N, F 2 , NR F2’ or CR F2 And, R F2’ is hydrogen, C 1-6 Alkyl, C 2-6 Alkenil, C 2-6 Alkinyl, C 3-12 Carbocyclyl, 3-12 member heterocyclyl, C 6-10 Aryl, 5-10 member heteroaryl, -S(=O)2R a -S(=O)2OR b -S(=O)2NR c R d -C(=O)R a , -C(=O)OR b , or -C(=O)NR c R d Alkyl, alkenyl, alkynyl, carbocykyl, heterocyclyl, aryl, or heteroaryl is one or more R u It may also be replaced with R F2 These are hydrogen, halogen, -CN, -NO2, -OH, -NH2, C 1-6 Alkyl, C 1-6 Alkoxy, C 1-6 Alkylamino, C 2-6 Alkenil, C 2-6 Alkinyl, C 3-12Carbocyclyl, 3-12 member heterocyclyl, C 6-10 Aryl, 5-10 member heteroaryl, -SR b -S(=O)R a -S(=O)2R a -S(=O)2OR b -S(=O)2NR c R d , -NR c S(=O)2R a , -NR c S(=O)R a , -NR c S(=O)2OR b , -NR c S(=O)2NR c R d , -NR b C(=O)NR c R d , -NR b C(=O)R a , -NR b C(=O)OR b -OS(=O)2R a -OS(=O)2OR b -OS(=O)2NR c R d -OC(=O)R a , -OC(=O)OR b -OC(=O)NR c R d -C(=O)R a , -C(=O)OR b , or -C(=O)NR c R d Alkyl, alkoxy, alkylamino, alkenyl, alkynyl, carbocykyl, heterocyclyl, aryl, or heteroaryl is one or more R u It may also be replaced with F 3 CR F3 , N, or NR F3’ And, R F3 These are hydrogen, halogen, -CN, -NO2, -OH, -NH2, C 1-6 Alkyl, C 1-6 Alkoxy, C 1-6 Alkylamino, C2-6 Alkenil, C 2-6 Alkinyl, C 3-12 Carbocyclyl, 3-12 member heterocyclyl, C 6-10 Aryl, 5-10 member heteroaryl, -SR b -S(=O)R a -S(=O)2R a -S(=O)2OR b -S(=O)2NR c R d , -NR c S(=O)2R a , -NR c S(=O)R a , -NR c S(=O)2OR b , -NR c S(=O)2NR c R d , -NR b C(=O)NR c R d , -NR b C(=O)R a , -NR b C(=O)OR b -OS(=O)2R a -OS(=O)2OR b -OS(=O)2NR c R d -OC(=O)R a , -OC(=O)OR b -OC(=O)NR c R d -C(=O)R a , -C(=O)OR b , or -C(=O)NR c R d Alkyl, alkoxy, alkylamino, alkenyl, alkynyl, carbocykyl, heterocyclyl, aryl, or heteroaryl is one or more R u It may also be replaced with R F3’ is hydrogen, C 1-6 Alkyl, C 2-6 Alkenil, C 2-6 Alkinyl, C 3-12 Carbocyclyl, 3-12 member heterocyclyl, C 6-10Aryl, 5-10 member heteroaryl, -S(=O)2R a -S(=O)2OR b -S(=O)2NR c R d -C(=O)R a , -C(=O)OR b , or -C(=O)NR c R d Alkyl, alkenyl, alkynyl, carbocykyl, heterocyclyl, aryl, or heteroaryl is one or more R u It may also be replaced with R F4 is -C(=O)NR 3a R 3b , or one or more R u It is a 5-6 member heteroaryl which may be substituted with R 3a and R 3b These are, independently, hydrogen and C 1-6 Alkyl, C 2-6 Alkenil, C 2-6 Alkinyl, C 3-12 Carbocyclyl, 3-12 member heterocyclyl, C 6-10 Aryl, 5-10 member heteroaryl, -S(=O)2R a -S(=O)2OR b -S(=O)2NR c R d -C(=O)R a , -C(=O)OR b , or -C(=O)NR c R d Alkyl, alkenyl, alkynyl, carbocykyl, heterocyclyl, aryl, or heteroaryl is one or more R u It may also be replaced with R 3a and R 3b These, together with the nitrogen atoms to which they are bonded, form a 3-12 membered heterocycle or a 5-10 membered heteroaryl, and the heterocycle or heteroaryl contains one or more R u It may be replaced with .

[0060] In certain embodiments, T is the formula of formula I-3-ia. TIFF2026521988000145.tif34128

[0061] In a particular embodiment, T is the formula in formula I-3-ib. TIFF2026521988000146.tif35128

[0062] In a particular embodiment, E 1 teeth, TIFF2026521988000147.tif8128,CR E1 , or N.

[0063] In a particular embodiment, E 2 teeth, TIFF2026521988000148.tif8128,CR E2 , or N.

[0064] In a particular embodiment, E 3 teeth, TIFF2026521988000149.tif8128,CR E3 , or N.

[0065] In a particular embodiment, E 1 , E 2 , and E 3 One of them is N. In a particular embodiment, E 1 , E 2 , and E 3 Two of them are N.

[0066] In a particular embodiment, R E1 , R E2 , R E3 , and R E4 These are independently hydrogen, halogens (e.g., -F, -Cl, -Br, or -I), -CN, -NO2, -OH, -NH2, and C 1-6Alkyl (e.g., methyl (C1), ethyl (C2), n-propyl (C3), i-propyl (C3), n-butyl (C4), i-butyl (C4), s-butyl (C4), t-butyl (C4), pentyl (C5), or hexyl (C6)), C 1-6 Alkoxy (e.g., methoxy (C1), ethoxy (C2), propoxy (C3), i-propoxy (C3), n-butoxy (C4), i-butoxy (C4), s-butoxy (C4), t-butoxy (C4), pentoxy (C5), or hexoxy (C6)), C 1-6 Alkylaminos (e.g., dimethylamino, diethylamino, di-n-propylamino, di-i-propylamino, di-n-butylamino, di-i-butylamino, di-s-butylamino, di-t-butylamino, dipentylamino, dihexylamino, methylethylamino, methyl-n-propylamino, methyl-i-propylamino, methyl-n-butylamino, methyl-i-butylamino, methyl-s-butylamino, methyl-t-butylamino, methylpentylamino, methylhexylamino, ethyl-n-propylamino, ethyl-i-propylamino, ethyl-n-butylamino) (No, ethyl-s-butylamino, ethyl-i-butylamino, ethyl-t-butylamino, ethylpentylamino, ethylhexylamino, propyl-n-butylamino, propyl-i-butylamino, propyl-s-butylamino, propyl-t-butylamino, propylpentyrylamino, propylhexylamino, n-butylpentylamino, i-butylpentylamino, s-butylpentylamino, t-butylpentylamino, n-butylhexylamino, i-butylhexylamino, s-butylhexylamino, t-butylpentylamino, n-butylhexylamino, i-butylhexylamino, s-butylhexylamino, t-butylhexylamino, or pentylhexylamino), C 2-6 Alkenyls (e.g., etenyl (C2), 1-propenyl (C3), 2-propenyl (C3), 1-butenyl (C4), 2-butenyl (C4), butadienyl (C4), pentenyl (C5), pentadienyl (C5), or hexenyl (C6)), C 2-6Alkynnyl (e.g., ethinyl (C2), 1-propynyl (C3), 2-propynyl (C3), 1-butynyl (C4), 2-butynyl (C4), pentynyl (C5), or hexynyl (C6)), C 3-12 Carbocyclyl (e.g., cyclopropyl (C3), cyclopropenyl (C3), cyclobutyl (C4), cyclobutenyl (C4), cyclopentyl (C5), cyclopentenyl (C5), cyclohexyl (C6), cyclohexenyl (C6), cyclohexadienyl (C6), cycloheptyl (C7), cycloheptenyl (C7), cycloheptadienyl (C7), cycloheptatrienyl (C7), cyclooctyl (C8), cyclooctenyl (C8), bicyclo[2.2.1]heptanyl (C7), bicyclo[2.2.2]octanyl (C8), cyclononyl (C9), cyclononenyl (C9), cyclodecyl (C) 10 ), cyclodecenyl (C 10 ), octahydro-1H-indenyl (C9), decahydronaphthalenyl (C9) 10 ), or spiro[4.5]decanil(C 10 )), 3-12 membered heterocyclines (e.g., heterocyclines containing one or two 3-8 membered rings and 1-5 heteroatoms selected from N, O, and S), C 6-10 Aryl (e.g., phenyl or naphthyl), 5-10 membered heteroaryl (e.g., heteroaryl containing one or two 5 or 6 membered rings and 1-5 heteroatoms selected from N, O, and S), -SR b -S(=O)R a -S(=O)2R a -S(=O)2OR b -S(=O)2NR c R d , -NR c S(=O)2R a , -NR c S(=O)R a , -NR c S(=O)2OR b , -NR c S(=O)2NR c R d , -NR b C(=O)NR cR d , -NR b C(=O)R a , -NR b C(=O)OR b -OS(=O)2R a -OS(=O)2OR b -OS(=O)2NR c R d -OC(=O)R a , -OC(=O)OR b -OC(=O)NR c R d -C(=O)R a , -C(=O)OR b , or -C(=O)NR c R d Alkyl, alkoxy, alkylamino, alkenyl, alkynyl, carbocykyl, heterocyclyl, aryl, or heteroaryl is one or more R u It may be replaced with .

[0067] In a particular embodiment, R E1 , R E2 , R E3 , and R E4 These are independently hydrogen, halogen, -CN, -NO2, -OH, -NH2, C 1-6 Alkyl, C 1-6 Alkoxy, C 1-6 Alkylamino, C 2-6 Alkenil, C 2-6 Alkinyl, C 3-12 Carbocyclyl, 3-12 member heterocyclyl, C 6-10 The aryl or 5-10 membered heteroaryl is an alkyl, alkoxy, alkylamino, alkenyl, alkynyl, carbocykrill, heterocyclyl, aryl, or heteroaryl, which has one or more R u It may be replaced with .

[0068] In a particular embodiment, R E1 , R E2 , R E3 , and R E4 These are independently hydrogen, halogen, -CN, -NO2, -OH, -NH2, C1-6 Alkyl, C 1-6 Alkoxy, C 1-6 Alkylamino, C 2-6 Alkenil, C 2-6 Alkinyl, C 3-6 Carbocyclyl, 3-6 membered heterocyclyl, C6 aryl, 5-6 membered heteroaryl, and alkyl, alkoxy, alkylamino, alkenyl, alkynyl, carbocykrill, heterocyclyl, aryl, or heteroaryl may be one or more R u It may be replaced with .

[0069] In a particular embodiment, R E1 , R E2 , R E3 , and R E4 These are independently hydrogen, halogen, -CN, -NO2, -OH, -NH2, C 1-6 Alkyl, C 1-6 Alkoxy, C 1-6 Alkylamino, C 2-6 Alkenil, C 2-6 Alkinyl, C 3-6 Carbocyclyl, or 3-6 membered heterocyclyl, wherein alkyl, alkoxy, alkylamino, alkenyl, alkynyl, carbocyclyl, or heterocyclyl is one or more R u It may be replaced with .

[0070] In a particular embodiment, R E1 , R E2 , R E3 , and R E4 These are independently hydrogen, halogen, -CN, -NO2, -OH, -NH2, C 1-6 Alkyl, C 1-6 Alkoxy, C 1-6 Alkylamino, C 3-6 Carbocyclyl, or 3-6 membered heterocyclyl, wherein alkyl, alkoxy, alkylamino, carbocyclyl, or heterocyclyl is one or more R u It may be replaced with .

[0071] In a particular embodiment, R E1 and RE3 They are independent, or R E1 or R E2 is hydrogen, halogen, or one or more R u Even if replaced by C 1-6 It is alkyl.

[0072] In a particular embodiment, R E4 Hydrogen, halogen, -CN, C 1-6 Alkyl, C 1-6 Alkoxy, C 1-6 Alkylamino, C 3-12 Carbocyclyl, 3-12 member heterocyclyl, or -S(=O)2R a Alkyl, alkoxy, alkylamino, carbocykyl, or heterocyclyl is one or more R u It may be replaced with .

[0073] In a particular embodiment, F 1 It is either C or N.

[0074] In a particular embodiment, F 2 , NR F2’ or CR F2 That is the case.

[0075] In a particular embodiment, F 3 , NR F3’ , N, or CR F3 That is the case.

[0076] In a particular embodiment, R F2’ and R F3’ Hydrogen and C are independent of each other. 1-6 Alkyl (e.g., methyl (C1), ethyl (C2), n-propyl (C3), i-propyl (C3), n-butyl (C4), i-butyl (C4), s-butyl (C4), t-butyl (C4), pentyl (C5), or hexyl (C6)), C 2-6Alkenyls (e.g., etenyl (C2), 1-propenyl (C3), 2-propenyl (C3), 1-butenyl (C4), 2-butenyl (C4), butadienyl (C4), pentenyl (C5), pentadienyl (C5), or hexenyl (C6)), C 2-6 Alkynnyl (e.g., ethinyl (C2), 1-propynyl (C3), 2-propynyl (C3), 1-butynyl (C4), 2-butynyl (C4), pentynyl (C5), or hexynyl (C6)), C 3-12 Carbocyclyl (e.g., cyclopropyl (C3), cyclopropenyl (C3), cyclobutyl (C4), cyclobutenyl (C4), cyclopentyl (C5), cyclopentenyl (C5), cyclohexyl (C6), cyclohexenyl (C6), cyclohexadienyl (C6), cycloheptyl (C7), cycloheptenyl (C7), cycloheptadienyl (C7), cycloheptatrienyl (C7), cyclooctyl (C8), cyclooctenyl (C8), bicyclo[2.2.1]heptanyl (C7), bicyclo[2.2.2]octanyl (C8), cyclononyl (C9), cyclononenyl (C9), cyclodecyl (C) 10 ), cyclodecenyl (C 10 ), octahydro-1H-indenyl (C9), decahydronaphthalenyl (C9) 10 ), or spiro[4.5]decanil(C 10 )), 3-12 membered heterocyclines (e.g., heterocyclines containing one or two 3-8 membered rings and 1-5 heteroatoms selected from N, O, and S), C 6-10 Aryl (e.g., phenyl or naphthyl), 5-10 membered heteroaryl (e.g., heteroaryl containing one or two 5 or 6 membered rings and 1-5 heteroatoms selected from N, O, and S), -S(=O)2R a -S(=O)2OR b -S(=O)2NR c R d -C(=O)R a , -C(=O)OR b , or -C(=O)NR c R dAlkyl, alkenyl, alkynyl, carbocykyl, heterocyclyl, aryl, or heteroaryl is one or more R u It may be replaced with .

[0077] In a particular embodiment, R F2’ and R F3’ Hydrogen and C are independent of each other. 1-6 Alkyl, C 2-6 Alkenil, C 2-6 Alkinyl, C 3-6 Carbocyclyl, 3-6 membered heterocyclyl, C6 aryl, 5-6 membered heteroaryl, -S(=O)2R a -S(=O)2OR b -S(=O)2NR c R d -C(=O)R a , -C(=O)OR b , or -C(=O)NR c R d Alkyl, alkenyl, alkynyl, carbocykyl, heterocyclyl, aryl, or heteroaryl is one or more R u It may be replaced with .

[0078] In a particular embodiment, R F2’ and R F3’ Hydrogen and C are independent of each other. 1-6 Alkyl, C 2-6 Alkenil, C 2-6 Alkinyl, C 3-6 Carbocyclyl, or 3-6 member heterocyclyl, -S(=O)2R a -S(=O)2OR b -S(=O)2NR c R d -C(=O)R a , -C(=O)OR b , or -C(=O)NR c R d Alkyl, alkenyl, alkynyl, carbocykyl, or heterocyclyl is one or more R u It may be replaced with .

[0079] In a particular embodiment, R F2’ and R F3’ Hydrogen and C are independent of each other. 1-6 Alkyl, C 3-6 Carbocyclyl, 3-6 member heterocyclyl, -S(=O)2R a -S(=O)2OR b -S(=O)2NR c R d -C(=O)R a , -C(=O)OR b , or -C(=O)NR c R d And alkyl, carbocykryl, or heterocyclyl is one or more R u It may be replaced with .

[0080] In a particular embodiment, R F2’ is hydrogen, or one or more R u Even if replaced by C 1-6 It is alkyl.

[0081] In a particular embodiment, R F2 and R F3 These are independently hydrogen, halogens (e.g., -F, -Cl, -Br, or -I), -CN, -NO2, -OH, -NH2, and C 1-6 Alkyl (e.g., methyl (C1), ethyl (C2), n-propyl (C3), i-propyl (C3), n-butyl (C4), i-butyl (C4), s-butyl (C4), t-butyl (C4), pentyl (C5), or hexyl (C6)), C 1-6 Alkoxy (e.g., methoxy (C1), ethoxy (C2), propoxy (C3), i-propoxy (C3), n-butoxy (C4), i-butoxy (C4), s-butoxy (C4), t-butoxy (C4), pentoxy (C5), or hexoxy (C6)), C 1-6Alkylaminos (e.g., dimethylamino, diethylamino, di-n-propylamino, di-i-propylamino, di-n-butylamino, di-i-butylamino, di-s-butylamino, di-t-butylamino, dipentylamino, dihexylamino, methylethylamino, methyl-n-propylamino, methyl-i-propylamino, methyl-n-butylamino, methyl-i-butylamino, methyl-s-butylamino, methyl-t-butylamino, methylpentylamino, methylhexylamino, ethyl-n-propylamino, ethyl-i-propylamino, ethyl-n-butylamino) (No, ethyl-s-butylamino, ethyl-i-butylamino, ethyl-t-butylamino, ethylpentylamino, ethylhexylamino, propyl-n-butylamino, propyl-i-butylamino, propyl-s-butylamino, propyl-t-butylamino, propylpentyrylamino, propylhexylamino, n-butylpentylamino, i-butylpentylamino, s-butylpentylamino, t-butylpentylamino, n-butylhexylamino, i-butylhexylamino, s-butylhexylamino, t-butylpentylamino, n-butylhexylamino, i-butylhexylamino, s-butylhexylamino, t-butylhexylamino, or pentylhexylamino), C 2-6 Alkenyls (e.g., etenyl (C2), 1-propenyl (C3), 2-propenyl (C3), 1-butenyl (C4), 2-butenyl (C4), butadienyl (C4), pentenyl (C5), pentadienyl (C5), or hexenyl (C6)), C 2-6 Alkynnyl (e.g., ethinyl (C2), 1-propynyl (C3), 2-propynyl (C3), 1-butynyl (C4), 2-butynyl (C4), pentynyl (C5), or hexynyl (C6)), C 3-12Carbocyclyl (e.g., cyclopropyl (C3), cyclopropenyl (C3), cyclobutyl (C4), cyclobutenyl (C4), cyclopentyl (C5), cyclopentenyl (C5), cyclohexyl (C6), cyclohexenyl (C6), cyclohexadienyl (C6), cycloheptyl (C7), cycloheptenyl (C7), cycloheptadienyl (C7), cycloheptatrienyl (C7), cyclooctyl (C8), cyclooctenyl (C8), bicyclo[2.2.1]heptanyl (C7), bicyclo[2.2.2]octanyl (C8), cyclononyl (C9), cyclononenyl (C9), cyclodecyl (C) 10 ), cyclodecenyl (C 10 ), octahydro-1H-indenyl (C9), decahydronaphthalenyl (C9) 10 ), or spiro[4.5]decanil(C 10 )), 3-12 membered heterocyclines (e.g., heterocyclines containing one or two 3-8 membered rings and 1-5 heteroatoms selected from N, O, and S), C 6-10 Aryl (e.g., phenyl or naphthyl), 5-10 membered heteroaryl (e.g., heteroaryl containing one or two 5 or 6 membered rings and 1-5 heteroatoms selected from N, O, and S), -SR b -S(=O)R a -S(=O)2R a -S(=O)2OR b -S(=O)2NR c R d , -NR c S(=O)2R a , -NR c S(=O)R a , -NR c S(=O)2OR b , -NR c S(=O)2NR c R d , -NR b C(=O)NR c R d , -NR b C(=O)R a , -NR b C(=O)OR b -OS(=O)2Ra -OS(=O)2OR b -OS(=O)2NR c R d -OC(=O)R a , -OC(=O)OR b -OC(=O)NR c R d -C(=O)R a , -C(=O)OR b , or -C(=O)NR c R d Alkyl, alkoxy, alkylamino, alkenyl, alkynyl, carbocykyl, heterocyclyl, aryl, or heteroaryl is one or more R u It may be replaced with .

[0082] In a particular embodiment, R F2 and R F3 These are independently hydrogen, halogen, -CN, -NO2, -OH, -NH2, C 1-6 Alkyl, C 1-6 Alkoxy, C 1-6 Alkylamino, C 2-6 Alkenil, C 2-6 Alkinyl, C 3-12 Carbocyclyl, 3-12 member heterocyclyl, C 6-10 The aryl or 5-10 membered heteroaryl is an alkyl, alkoxy, alkylamino, alkenyl, alkynyl, carbocykrill, heterocyclyl, aryl, or heteroaryl, which has one or more R u It may be replaced with .

[0083] In a particular embodiment, R F2 and R F3 These are independently hydrogen, halogen, -CN, -NO2, -OH, -NH2, C 1-6 Alkyl, C 1-6 Alkoxy, C 1-6 Alkylamino, C 2-6 Alkenil, C 2-6 Alkinyl, C 3-6Carbocyclyl, 3-6 membered heterocyclyl, C6 aryl, or 5-6 membered heteroaryl, and alkyl, alkoxy, alkylamino, alkenyl, alkynyl, carbocykrill, heterocyclyl, aryl, or heteroaryl is one or more R u It may be replaced with .

[0084] In a particular embodiment, R F2 and R F3 These are independently hydrogen, halogen, -CN, -NO2, -OH, -NH2, C 1-6 Alkyl, C 1-6 Alkoxy, C 1-6 Alkylamino, C 2-6 Alkenil, C 2-6 Alkinyl, C 3-6 Carbocyclyl, or 3-6 membered heterocyclyl, wherein alkyl, alkoxy, alkylamino, alkenyl, alkynyl, carbocyclyl, or heterocyclyl is one or more R u It may be replaced with .

[0085] In a particular embodiment, R F2 and R F3 These are independently hydrogen, halogen, -CN, -NO2, -OH, -NH2, C 1-6 Alkyl, C 1-6 Alkoxy, C 1-6 Alkylamino, C 3-6 Carbocyclyl, or 3-6 membered heterocyclyl, wherein alkyl, alkoxy, alkylamino, carbocyclyl, or heterocyclyl is one or more R u It may be replaced with .

[0086] In a particular embodiment, R F3 It is hydrogen.

[0087] In a particular embodiment, R F4 is -C(=O)NR 3a R 3b or one or more R uA 5-6 membered heteroaryl (for example, a heteroaryl containing one 5-6 membered ring and 1-3 heteroatoms selected from N, O, and S) which may be substituted.

[0088] In a particular embodiment, R 3a and R 3b These are, independently, hydrogen and C 1-6 Alkyl (e.g., methyl (C1), ethyl (C2), n-propyl (C3), i-propyl (C3), n-butyl (C4), i-butyl (C4), s-butyl (C4), t-butyl (C4), pentyl (C5), or hexyl (C6)), C 2-6 Alkenyls (e.g., etenyl (C2), 1-propenyl (C3), 2-propenyl (C3), 1-butenyl (C4), 2-butenyl (C4), butadienyl (C4), pentenyl (C5), pentadienyl (C5), or hexenyl (C6)), C 2-6 Alkynnyl (e.g., ethinyl (C2), 1-propynyl (C3), 2-propynyl (C3), 1-butynyl (C4), 2-butynyl (C4), pentynyl (C5), or hexynyl (C6)), C 3-12 Carbocyclyl (e.g., cyclopropyl (C3), cyclopropenyl (C3), cyclobutyl (C4), cyclobutenyl (C4), cyclopentyl (C5), cyclopentenyl (C5), cyclohexyl (C6), cyclohexenyl (C6), cyclohexadienyl (C6), cycloheptyl (C7), cycloheptenyl (C7), cycloheptadienyl (C7), cycloheptatrienyl (C7), cyclooctyl (C8), cyclooctenyl (C8), bicyclo[2.2.1]heptanyl (C7), bicyclo[2.2.2]octanyl (C8), cyclononyl (C9), cyclononenyl (C9), cyclodecyl (C) 10 ), cyclodecenyl (C 10 ), octahydro-1H-indenyl (C9), decahydronaphthalenyl (C9) 10 ), or spiro[4.5]decanil(C 10)), 3-12 membered heterocyclines (e.g., heterocyclines containing one or two 3-8 membered rings and 1-5 heteroatoms selected from N, O, and S), C 6-10 Aryl (e.g., phenyl or naphthyl), 5-10 membered heteroaryl (e.g., heteroaryl containing one or two 5 or 6 membered rings and 1-5 heteroatoms selected from N, O, and S), -S(=O)2R a -S(=O)2OR b -S(=O)2NR c R d -C(=O)R a , -C(=O)OR b , or -C(=O)NR c R d Alkyl, alkenyl, alkynyl, carbocykyl, heterocyclyl, aryl, or heteroaryl is one or more R u It may be replaced with .

[0089] In a particular embodiment, R 3a and R 3b Hydrogen and C are independent of each other. 1-6 Alkyl, C 2-6 Alkenil, C 2-6 Alkinyl, C 3-6 Carbocyclyl, 3-6 membered heterocyclyl, C6 aryl, 5-6 membered heteroaryl, -S(=O)2R a -S(=O)2OR b -S(=O)2NR c R d -C(=O)R a , -C(=O)OR b , or -C(=O)NR c R d Alkyl, alkenyl, alkynyl, carbocykyl, heterocyclyl, aryl, or heteroaryl is one or more R u It may be replaced with .

[0090] In a particular embodiment, R 3a and R 3b Hydrogen and C are independent of each other. 1-6 Alkyl, C 2-6Alkenil, C 2-6 Alkinyl, C 3-6 Carbocyclyl, or 3-6 member heterocyclyl, -S(=O)2R a -S(=O)2OR b -S(=O)2NR c R d -C(=O)R a , -C(=O)OR b , or -C(=O)NR c R d Alkyl, alkenyl, alkynyl, carbocykyl, or heterocyclyl is one or more R u It may be replaced with .

[0091] In a particular embodiment, R 3a and R 3b Hydrogen and C are independent of each other. 1-6 Alkyl, C 3-6 Carbocyclyl, 3-6 member heterocyclyl, -S(=O)2R a -S(=O)2OR b -S(=O)2NR c R d -C(=O)R a , -C(=O)OR b , or -C(=O)NR c R d And alkyl, carbocykryl, or heterocyclyl is one or more R u It may be replaced with .

[0092] In a particular embodiment, R 3a and R 3b These, together with the nitrogen atoms to which they are bonded, form a 3-12 membered heterocycle (e.g., a heterocyclil containing one or two 3-8 membered rings and 1-5 heteroatoms selected from N, O, and S), or a 5-10 membered heteroaryl (e.g., a heteroaryl containing one or two 5 or 6 membered rings and 1-5 heteroatoms selected from N, O, and S), and the heterocycle or heteroaryl contains one or more R u It may be replaced with .

[0093] In a particular embodiment, R 3a and R 3b It is independently of hydrogen, or one or more R u Even if replaced by C 1-6 It is alkyl.

[0094] In a particular embodiment, T is the formula in formula I-3-ii, TIFF2026521988000150.tif28128In formula, G 1 teeth, TIFF2026521988000151.tif8128, N, or CR G1 And, G 2 teeth, TIFF2026521988000152.tif8128, N, or CR G2 And, G 3 teeth, TIFF2026521988000153.tif8128, N, or CR G3 And, TIFF2026521988000154.tif8128 shows adhesion to L, R G1 , R G2 , R G3 , and R G4 These are independently hydrogen, halogen, -CN, -NO2, -OH, -NH2, C 1-6 Alkyl, C 1-6 Alkoxy, C 1-6 Alkylamino, C 2-6 Alkenil, C 2-6 Alkinyl, C 3-12 Carbocyclyl, 3-12 member heterocyclyl, C 6-10 Aryl, 5-10 member heteroaryl, -SR b -S(=O)R a -S(=O)2R a -S(=O)2OR b -S(=O)2NR c R d , -NR c S(=O)2R a , -NR cS(=O)R a , -NR c S(=O)2OR b , -NR c S(=O)2NR c R d , -NR b C(=O)NR c R d , -NR b C(=O)R a , -NR b C(=O)OR b -OS(=O)2R a -OS(=O)2OR b -OS(=O)2NR c R d -OC(=O)R a , -OC(=O)OR b -OC(=O)NR c R d -C(=O)R a , -C(=O)OR b , or -C(=O)NR c R d Alkyl, alkoxy, alkylamino, alkenyl, alkynyl, carbocykyl, heterocyclyl, aryl, or heteroaryl is one or more R u It may also be replaced with H 1 C(R H1 )2, NR H1’ , or O, H 2 C(R H2 )2, NR H2’ , or O, R H1 and R H2 Each occurrence is independently of hydrogen, halogen, -CN, -NO2, -OH, -NH2, C 1-6 Alkyl, C 1-6 Alkoxy, C 1-6 Alkylamino, C 2-6 Alkenil, C 2-6 Alkinyl, C 3-12 Carbocyclyl, 3-12 member heterocyclyl, C 6-10The aryl or 5-10 membered heteroaryl is an alkyl, alkoxy, alkylamino, alkenyl, alkynyl, carbocykrill, heterocyclyl, aryl, or heteroaryl, which has one or more R u Is it okay if it is replaced with, or Two R's H1 or two R's H2 Together with the carbon atoms to which they are bonded, C 3-6 It forms a carbocyclic ring or a 3- to 6-membered heterocyclic ring, and the carbocyclic ring or heterocyclic ring has one or more R u It may also be replaced with R H1’ and R H2’ Hydrogen and C are independent of each other. 1-6 Alkyl, C 3-6 Carbocyclyl, 3-6 member heterocyclyl, -S(=O)2R a -S(=O)2OR b -S(=O)2NR c R d -C(=O)R a , -C(=O)OR b , or -C(=O)NR c R d And alkyl, carbocykryl, or heterocyclyl is one or more R u It may be replaced with .

[0095] In a particular embodiment, T is the formula in formula I-3-ii, TIFF2026521988000155.tif28128In formula, G 1 CR G1 And, G 2 teeth, The filename is TIFF2026521988000156.tif8128. G 3 is N or CR G3 And, TIFF2026521988000157.tif8128 shows adhesion to L, R G1 , R G3 , and R G4is independently hydrogen, C 1-6 alkyl, or 3- to 12-membered heterocyclyl, H 1 is NR H1’ where [[ID=⑨]] H 2 is NR H2’ where R H1’ and R H2’ are independently C 1-6 alkyl.

[0096] In certain embodiments, T is of the formula I-3-ii-a. TIFF2026521⑨88000158.tif35128

[0097] In certain embodiments, G 1 is TIFF2026521⑨88000159.tif8128, N, or CR G1 where <00⑨703>

[0098] In certain embodiments, G 2 is TIFF2026521⑨88000160.tif8128, N, or CR G2 where

[0099] In certain embodiments, G 3 is TIFF2026521⑨88000161.tif8②8, N, or CR G3 where

[0100] In certain embodiments, R G1 , R G2 , R G3 and R G4 are independently hydrogen, halogen (e.g., -F, -Cl, -Br, or -I), -CN, -NO₂, -OH, -NH₂, C 1-6Alkyl (e.g., methyl (C1), ethyl (C2), n-propyl (C3), i-propyl (C3), n-butyl (C4), i-butyl (C4), s-butyl (C4), t-butyl (C4), pentyl (C5), or hexyl (C6)), C 1-6 Alkoxy (e.g., methoxy (C1), ethoxy (C2), propoxy (C3), i-propoxy (C3), n-butoxy (C4), i-butoxy (C4), s-butoxy (C4), t-butoxy (C4), pentoxy (C5), or hexoxy (C6)), C 1-6 Alkylaminos (e.g., dimethylamino, diethylamino, di-n-propylamino, di-i-propylamino, di-n-butylamino, di-i-butylamino, di-s-butylamino, di-t-butylamino, dipentylamino, dihexylamino, methylethylamino, methyl-n-propylamino, methyl-i-propylamino, methyl-n-butylamino, methyl-i-butylamino, methyl-s-butylamino, methyl-t-butylamino, methylpentylamino, methylhexylamino, ethyl-n-propylamino, ethyl-i-propylamino, ethyl-n-butylamino) (No, ethyl-s-butylamino, ethyl-i-butylamino, ethyl-t-butylamino, ethylpentylamino, ethylhexylamino, propyl-n-butylamino, propyl-i-butylamino, propyl-s-butylamino, propyl-t-butylamino, propylpentyrylamino, propylhexylamino, n-butylpentylamino, i-butylpentylamino, s-butylpentylamino, t-butylpentylamino, n-butylhexylamino, i-butylhexylamino, s-butylhexylamino, t-butylpentylamino, n-butylhexylamino, i-butylhexylamino, s-butylhexylamino, t-butylhexylamino, or pentylhexylamino), C 2-6 Alkenyls (e.g., etenyl (C2), 1-propenyl (C3), 2-propenyl (C3), 1-butenyl (C4), 2-butenyl (C4), butadienyl (C4), pentenyl (C5), pentadienyl (C5), or hexenyl (C6)), C 2-6Alkynnyl (e.g., ethinyl (C2), 1-propynyl (C3), 2-propynyl (C3), 1-butynyl (C4), 2-butynyl (C4), pentynyl (C5), or hexynyl (C6)), C 3-12 Carbocyclyl (e.g., cyclopropyl (C3), cyclopropenyl (C3), cyclobutyl (C4), cyclobutenyl (C4), cyclopentyl (C5), cyclopentenyl (C5), cyclohexyl (C6), cyclohexenyl (C6), cyclohexadienyl (C6), cycloheptyl (C7), cycloheptenyl (C7), cycloheptadienyl (C7), cycloheptatrienyl (C7), cyclooctyl (C8), cyclooctenyl (C8), bicyclo[2.2.1]heptanyl (C7), bicyclo[2.2.2]octanyl (C8), cyclononyl (C9), cyclononenyl (C9), cyclodecyl (C) 10 ), cyclodecenyl (C 10 ), octahydro-1H-indenyl (C9), decahydronaphthalenyl (C9) 10 ), or spiro[4.5]decanil(C 10 )), 3-12 membered heterocyclines (e.g., heterocyclines containing one or two 3-8 membered rings and 1-5 heteroatoms selected from N, O, and S), C 6-10 Aryl (e.g., phenyl or naphthyl), 5-10 membered heteroaryl (e.g., heteroaryl containing one or two 5 or 6 membered rings and 1-5 heteroatoms selected from N, O, and S), -SR b -S(=O)R a -S(=O)2R a -S(=O)2OR b -S(=O)2NR c R d , -NR c S(=O)2R a , -NR c S(=O)R a , -NR c S(=O)2OR b , -NR c S(=O)2NR c R d , -NR b C(=O)NR cR d , -NR b C(=O)R a , -NR b C(=O)OR b -OS(=O)2R a -OS(=O)2OR b -OS(=O)2NR c R d -OC(=O)R a , -OC(=O)OR b -OC(=O)NR c R d -C(=O)R a , -C(=O)OR b , or -C(=O)NR c R d Alkyl, alkoxy, alkylamino, alkenyl, alkynyl, carbocykyl, heterocyclyl, aryl, or heteroaryl is one or more R u It may be replaced with .

[0101] In a particular embodiment, R G1 , R G2 , R G3 , and R G4 These are independently hydrogen, halogen, -CN, -NO2, -OH, -NH2, C 1-6 Alkyl, C 1-6 Alkoxy, C 1-6 Alkylamino, C 2-6 Alkenil, C 2-6 Alkinyl, C 3-12 Carbocyclyl, 3-12 member heterocyclyl, C 6-10 The aryl or 5-10 membered heteroaryl is an alkyl, alkoxy, alkylamino, alkenyl, alkynyl, carbocykrill, heterocyclyl, aryl, or heteroaryl, which has one or more R u It may be replaced with .

[0102] In a particular embodiment, R G1 , R G2 , R G3 , and R G4 These are independently hydrogen, halogen, -CN, -NO2, -OH, -NH2, C1-6 Alkyl, C 1-6 Alkoxy, C 1-6 Alkylamino, C 2-6 Alkenil, C 2-6 Alkinyl, C 3-6 Carbocyclyl, 3-6 membered heterocyclyl, C6 aryl, or 5-6 membered heteroaryl, and alkyl, alkoxy, alkylamino, alkenyl, alkynyl, carbocykrill, heterocyclyl, aryl, or heteroaryl is one or more R u It may be replaced with .

[0103] In a particular embodiment, R G1 , R G2 , R G3 , and R G4 These are independently hydrogen, halogen, -CN, -NO2, -OH, -NH2, C 1-6 Alkyl, C 1-6 Alkoxy, C 1-6 Alkylamino, C 2-6 Alkenil, C 2-6 Alkinyl, C 3-6 Carbocyclyl, or 3-6 membered heterocyclyl, wherein alkyl, alkoxy, alkylamino, alkenyl, alkynyl, carbocyclyl, or heterocyclyl is one or more R u It may be replaced with .

[0104] In a particular embodiment, R G1 , R G2 , R G3 , and R G4 These are independently hydrogen, halogen, -CN, -NO2, -OH, -NH2, C 1-6 Alkyl, C 1-6 Alkoxy, C 1-6 Alkylamino, C 3-6 Carbocyclyl, or 3-6 membered heterocyclyl, wherein alkyl, alkoxy, alkylamino, carbocyclyl, or heterocyclyl is one or more R u It may be replaced with .

[0105] In a particular embodiment, R G1 and RG3 Both are hydrogen.

[0106] In a particular embodiment, R G4 is hydrogen, C 1-6 Alkyl, C 1-6 Alkoxy, C 1-6 Alkylamino, C 2-6 Alkenyl, or 3-12 membered heterocyclyl, wherein alkyl, alkoxy, alkylamino, alkenyl, or heterocyclyl is one or more R u It may be replaced with .

[0107] In a particular embodiment, R G4 C 1-6 Alkyl, C 1-6 Alkylamino and 3-12 membered heterocyclyl, wherein alkyl, alkylamino, or heterocyclyl is one or more R u It may be replaced with .

[0108] In a particular embodiment, R G4 C 1-6 Alkyl, C 1-6 Alkylamino and 3-12 membered heterocyclyl, wherein alkyl, alkylamino, or heterocyclyl contains one or more -OH groups, halogens, and C groups. 1-6 It may be substituted with alkyl.

[0109] In a particular embodiment, H 1 C(R H1 )2, NR H1’ , or O.

[0110] In a particular embodiment, H 2 C(R H2 )2, NR H2’ , or O.

[0111] In a particular embodiment, H 1 , NR H1’ H 2 , NR H2’ That is the case.

[0112] In a particular embodiment, R H1 and R H2 Each occurrence is independent of hydrogen, halogen (e.g., -F, -Cl, -Br, or -I), -CN, -NO2, -OH, -NH2, C 1-6 Alkyl (e.g., methyl (C1), ethyl (C2), n-propyl (C3), i-propyl (C3), n-butyl (C4), i-butyl (C4), s-butyl (C4), t-butyl (C4), pentyl (C5), or hexyl (C6)), C 1-6 Alkoxy (e.g., methoxy (C1), ethoxy (C2), propoxy (C3), i-propoxy (C3), n-butoxy (C4), i-butoxy (C4), s-butoxy (C4), t-butoxy (C4), pentoxy (C5), or hexoxy (C6)), C 1-6 Alkylaminos (e.g., dimethylamino, diethylamino, di-n-propylamino, di-i-propylamino, di-n-butylamino, di-i-butylamino, di-s-butylamino, di-t-butylamino, dipentylamino, dihexylamino, methylethylamino, methyl-n-propylamino, methyl-i-propylamino, methyl-n-butylamino, methyl-i-butylamino, methyl-s-butylamino, methyl-t-butylamino, methylpentylamino, methylhexylamino, ethyl-n-propylamino, ethyl-i-propylamino, ethyl-n-butylamino) (No, ethyl-s-butylamino, ethyl-i-butylamino, ethyl-t-butylamino, ethylpentylamino, ethylhexylamino, propyl-n-butylamino, propyl-i-butylamino, propyl-s-butylamino, propyl-t-butylamino, propylpentyrylamino, propylhexylamino, n-butylpentylamino, i-butylpentylamino, s-butylpentylamino, t-butylpentylamino, n-butylhexylamino, i-butylhexylamino, s-butylhexylamino, t-butylpentylamino, n-butylhexylamino, i-butylhexylamino, s-butylhexylamino, t-butylhexylamino, or pentylhexylamino), C 2-6Alkenyls (e.g., etenyl (C2), 1-propenyl (C3), 2-propenyl (C3), 1-butenyl (C4), 2-butenyl (C4), butadienyl (C4), pentenyl (C5), pentadienyl (C5), or hexenyl (C6)), C 2-6 Alkynnyl (e.g., ethinyl (C2), 1-propynyl (C3), 2-propynyl (C3), 1-butynyl (C4), 2-butynyl (C4), pentynyl (C5), or hexynyl (C6)), C 3-12 Carbocyclyl (e.g., cyclopropyl (C3), cyclopropenyl (C3), cyclobutyl (C4), cyclobutenyl (C4), cyclopentyl (C5), cyclopentenyl (C5), cyclohexyl (C6), cyclohexenyl (C6), cyclohexadienyl (C6), cycloheptyl (C7), cycloheptenyl (C7), cycloheptadienyl (C7), cycloheptatrienyl (C7), cyclooctyl (C8), cyclooctenyl (C8), bicyclo[2.2.1]heptanyl (C7), bicyclo[2.2.2]octanyl (C8), cyclononyl (C9), cyclononenyl (C9), cyclodecyl (C) 10 ), cyclodecenyl (C 10 ), octahydro-1H-indenyl (C9), decahydronaphthalenyl (C9) 10 ), or spiro[4.5]decanil(C 10 )), 3-12 membered heterocyclines (e.g., heterocyclines containing one or two 3-8 membered rings and 1-5 heteroatoms selected from N, O, and S), C 6-10 The aryl (e.g., phenyl or naphthyl) or 5-10 membered heteroaryl (e.g., a heteroaryl containing one or two 5 or 6 membered rings and 1-5 heteroatoms selected from N, O, and S) is an alkyl, alkoxy, alkylamino, alkenyl, alkynyl, carbocykryl, heterocyclyl, aryl, or heteroaryl, which has one or more R u It may be replaced with .

[0113] In a particular embodiment, R H1 and R H2Each occurrence is independently of hydrogen, halogen, -CN, -NO2, -OH, -NH2, C 1-6 Alkyl, C 1-6 Alkoxy, C 1-6 Alkylamino, C 2-6 Alkenil, C 2-6 Alkinyl, C 3-6 Carbocyclyl, 3-6 membered heterocyclyl, C6 aryl, or 5-6 membered heteroaryl, and alkyl, alkoxy, alkylamino, alkenyl, alkynyl, carbocykrill, heterocyclyl, aryl, or heteroaryl is one or more R u It may be replaced with .

[0114] In a particular embodiment, R H1 and R H2 Each occurrence is independently of hydrogen, halogen, -CN, -NO2, -OH, -NH2, C 1-6 Alkyl, C 1-6 Alkoxy, C 1-6 Alkylamino, C 2-6 Alkenil, C 2-6 Alkinyl, C 3-6 Carbocyclyl, or 3-6 membered heterocyclyl, wherein alkyl, alkoxy, alkylamino, alkenyl, alkynyl, carbocyclyl, or heterocyclyl is one or more R u It may be replaced with .

[0115] In a particular embodiment, R H1 and R H2 Each occurrence is independently of hydrogen, halogen, -CN, -NO2, -OH, -NH2, C 1-6 Alkyl, C 1-6 Alkoxy, C 1-6 Alkylamino, C 3-6 Carbocyclyl, or 3-6 membered heterocyclyl, wherein alkyl, alkoxy, alkylamino, carbocyclyl, or heterocyclyl is one or more R u It may be replaced with .

[0116] In a particular embodiment, R H1’ and R H2’C 1-6 It is alkyl.

[0117] In a particular embodiment, R H1’ and R H2’ These are independently hydrogen or C 1-6 It is alkyl.

[0118] In certain embodiments, two R H1 or two R's H2 Together with the carbon atoms to which they are bonded, C 3-6 Carbocyclyls (e.g., cyclopropyl (C3), cyclopropenyl (C3), cyclobutyl (C4), cyclobutenyl (C4), cyclopentyl (C5), cyclopentenyl (C5), cyclohexyl (C6), cyclohexenyl (C6), or cyclohexadienyl (C6)) or 3-6 membered heterocyclyls (e.g., heterocyclyls containing one 3-6 membered ring and 1-3 heteroatoms selected from N, O, and S), wherein the carbocyclic or heterocyclic ring contains one or more R u It may be replaced with .

[0119] In a particular embodiment, R H1’ and R H2’ Hydrogen and C are independent of each other. 1-6 Alkyl (e.g., methyl (C1), ethyl (C2), n-propyl (C3), i-propyl (C3), n-butyl (C4), i-butyl (C4), s-butyl (C4), t-butyl (C4), pentyl (C5), or hexyl (C6)), C 3-6 Carbocyclyls (e.g., cyclopropyl (C3), cyclopropenyl (C3), cyclobutyl (C4), cyclobutenyl (C4), cyclopentyl (C5), cyclopentenyl (C5), cyclohexyl (C6), cyclohexenyl (C6), or cyclohexadienyl (C6)), 3-6 membered heterocyclyls (e.g., heterocyclyls containing one 3-6 membered ring and 1-3 heteroatoms selected from N, O, and S), -S(=O)2R a -S(=O)2OR b -S(=O)2NR c Rd -C(=O)R a , -C(=O)OR b , or -C(=O)NR c R d And alkyl, carbocykryl, or heterocyclyl is one or more R u It may be replaced with .

[0120] In certain embodiments, T is an expression of formula I-3-ii-a-1, I-3-ii-a-2, I-3-ii-a-3, I-3-ii-a-4, or I-3-ii-a-5. TIFF2026521988000162.tif54128

[0121] In certain embodiments, T is Selected from the group consisting of TIFF2026521988000163.tif109132.

[0122] In a particular embodiment, T is the formula in formula I-3-iii, TIFF2026521988000164.tif28128In formula, TIFF2026521988000165.tif8128 shows adhesion to L, I 1 C(R I1 )2, NR I1’ , or O, I 2 C(R I2 )2, NR I2’ , or O, R I1 and R I2 Each occurrence is independently of hydrogen, halogen, -CN, -NO2, -OH, -NH2, C 1-6 Alkyl, C 1-6 Alkoxy, C 1-6 Alkylamino, C 2-6 Alkenil, C 2-6 Alkinyl, C 3-12 Carbocyclyl, 3-12 member heterocyclyl, C 6-10The aryl or 5-10 membered heteroaryl is an alkyl, alkoxy, alkylamino, alkenyl, alkynyl, carbocykrill, heterocyclyl, aryl, or heteroaryl, which has one or more R u Is it okay if it is replaced with, or Two R's I1 or two R's I2 Together with the carbon atoms to which they are bonded, C 3-6 It forms a carbocyclic ring or a 3- to 6-membered heterocyclic ring, and the carbocyclic ring or heterocyclic ring has one or more R u It may also be replaced with R I1’ and R I2’ Hydrogen and C are independent of each other. 1-6 Alkyl, C 3-6 Carbocyclyl, 3-6 member heterocyclyl, -S(=O)2R a -S(=O)2OR b -S(=O)2NR c R d -C(=O)R a , -C(=O)OR b , or -C(=O)NR c R d And alkyl, carbocykryl, or heterocyclyl is one or more R u It may also be replaced with Each R I These are independently oxo, halogen, -CN, -NO2, -OH, -NH2, C 1-6 Alkyl, C 1-6 Alkoxy, C 1-6 Alkylamino, C 2-6 Alkenil, C 2-6 Alkinyl, C 3-12 Carbocyclyl, 3-12 member heterocyclyl, C 6-10 Aryl, 5-10 member heteroaryl, -SR b -S(=O)R a -S(=O)2R a -S(=O)2OR b -S(=O)2NR c R d , -NR c S(=O)2R a , -NRc S(=O)R a , -NR c S(=O)2OR b , -NR c S(=O)2NR c R d , -NR b C(=O)NR c R d , -NR b C(=O)R a , -NR b C(=O)OR b -OS(=O)2R a -OS(=O)2OR b -OS(=O)2NR c R d -OC(=O)R a , -OC(=O)OR b -OC(=O)NR c R d -C(=O)R a , -C(=O)OR b , or -C(=O)NR c R d Alkyl, alkoxy, alkylamino, alkenyl, alkynyl, carbocykyl, heterocyclyl, aryl, or heteroaryl is one or more R u It may also be replaced with i is an integer selected from 0 to 4. J 1 is N or CR J1 And, J 2 is N or CR J2 And, R J1 , R J2 , and R J3 These are independently hydrogen, halogen, -CN, -NO2, -OH, -NH2, C 1-6 Alkyl, C 1-6 Alkoxy, C 1-6 Alkylamino, C 2-6 Alkenil, C 2-6 Alkinyl, C 3-12 Carbocyclyl, 3-12 member heterocyclyl, C 6-10 Aryl, 5-10 member heteroaryl, -SRb -S(=O)R a -S(=O)2R a -S(=O)2OR b -S(=O)2NR c R d , -NR c S(=O)2R a , -NR c S(=O)R a , -NR c S(=O)2OR b , -NR c S(=O)2NR c R d , -NR b C(=O)NR c R d , -NR b C(=O)R a , -NR b C(=O)OR b -OS(=O)2R a -OS(=O)2OR b -OS(=O)2NR c R d -OC(=O)R a , -OC(=O)OR b -OC(=O)NR c R d -C(=O)R a , -C(=O)OR b , or -C(=O)NR c R d Alkyl, alkoxy, alkylamino, alkenyl, alkynyl, carbocykyl, heterocyclyl, aryl, or heteroaryl is one or more R u It may be replaced with .

[0123] In a particular embodiment, T is the formula in formula I-3-iii-a. TIFF2026521988000166.tif30128

[0124] In a particular embodiment, I 1 C(R I1 )2, NR I1’ , or O.

[0125] In a particular embodiment, I 2 C(R I2 )2, NR I2’ , or O.

[0126] In a particular embodiment, I 1 , NR I1’ And I 2 , NR I2’ That is the case.

[0127] In a particular embodiment, R I1 and R I2 Each occurrence is independent of oxo, hydrogen, halogen (e.g., -F, -Cl, -Br, or -I), -CN, -NO2, -OH, -NH2, C 1-6 Alkyl (e.g., methyl (C1), ethyl (C2), n-propyl (C3), i-propyl (C3), n-butyl (C4), i-butyl (C4), s-butyl (C4), t-butyl (C4), pentyl (C5), or hexyl (C6)), C 1-6 Alkoxy (e.g., methoxy (C1), ethoxy (C2), propoxy (C3), i-propoxy (C3), n-butoxy (C4), i-butoxy (C4), s-butoxy (C4), t-butoxy (C4), pentoxy (C5), or hexoxy (C6)), C 1-6Alkylaminos (e.g., dimethylamino, diethylamino, di-n-propylamino, di-i-propylamino, di-n-butylamino, di-i-butylamino, di-s-butylamino, di-t-butylamino, dipentylamino, dihexylamino, methylethylamino, methyl-n-propylamino, methyl-i-propylamino, methyl-n-butylamino, methyl-i-butylamino, methyl-s-butylamino, methyl-t-butylamino, methylpentylamino, methylhexylamino, ethyl-n-propylamino, ethyl-i-propylamino, ethyl-n-butylamino) (No, ethyl-s-butylamino, ethyl-i-butylamino, ethyl-t-butylamino, ethylpentylamino, ethylhexylamino, propyl-n-butylamino, propyl-i-butylamino, propyl-s-butylamino, propyl-t-butylamino, propylpentyrylamino, propylhexylamino, n-butylpentylamino, i-butylpentylamino, s-butylpentylamino, t-butylpentylamino, n-butylhexylamino, i-butylhexylamino, s-butylhexylamino, t-butylpentylamino, n-butylhexylamino, i-butylhexylamino, s-butylhexylamino, t-butylhexylamino, or pentylhexylamino), C 2-6 Alkenyls (e.g., etenyl (C2), 1-propenyl (C3), 2-propenyl (C3), 1-butenyl (C4), 2-butenyl (C4), butadienyl (C4), pentenyl (C5), pentadienyl (C5), or hexenyl (C6)), C 2-6 Alkynnyl (e.g., ethinyl (C2), 1-propynyl (C3), 2-propynyl (C3), 1-butynyl (C4), 2-butynyl (C4), pentynyl (C5), or hexynyl (C6)), C 3-12Carbocyclyl (e.g., cyclopropyl (C3), cyclopropenyl (C3), cyclobutyl (C4), cyclobutenyl (C4), cyclopentyl (C5), cyclopentenyl (C5), cyclohexyl (C6), cyclohexenyl (C6), cyclohexadienyl (C6), cycloheptyl (C7), cycloheptenyl (C7), cycloheptadienyl (C7), cycloheptatrienyl (C7), cyclooctyl (C8), cyclooctenyl (C8), bicyclo[2.2.1]heptanyl (C7), bicyclo[2.2.2]octanyl (C8), cyclononyl (C9), cyclononenyl (C9), cyclodecyl (C) 10 ), cyclodecenyl (C 10 ), octahydro-1H-indenyl (C9), decahydronaphthalenyl (C9) 10 ), or spiro[4.5]decanil(C 10 )), 3-12 membered heterocyclines (e.g., heterocyclines containing one or two 3-8 membered rings and 1-5 heteroatoms selected from N, O, and S), C 6-10 The aryl (e.g., phenyl or naphthyl) or 5-10 membered heteroaryl (e.g., a heteroaryl containing one or two 5 or 6 membered rings and 1-5 heteroatoms selected from N, O, and S) is an alkyl, alkoxy, alkylamino, alkenyl, alkynyl, carbocykryl, heterocyclyl, aryl, or heteroaryl, which has one or more R u It may be replaced with .

[0128] In a particular embodiment, R I1 and R I2 Each of these occurrences is independent of oxo, hydrogen, halogen, -CN, -NO2, -OH, -NH2, and C. 1-6 Alkyl, C 1-6 Alkoxy, C 1-6 Alkylamino, C 2-6 Alkenil, C 2-6 Alkinyl, C 3-6Carbocyclyl, 3-6 membered heterocyclyl, C6 aryl, or 5-6 membered heteroaryl, and alkyl, alkoxy, alkylamino, alkenyl, alkynyl, carbocykrill, heterocyclyl, aryl, or heteroaryl is one or more R u It may be replaced with .

[0129] In a particular embodiment, R I1 and R I2 Each of these occurrences is independent of oxo, hydrogen, halogen, -CN, -NO2, -OH, -NH2, C 1-6 Alkyl, C 1-6 Alkoxy, C 1-6 Alkylamino, C 2-6 Alkenil, C 2-6 Alkinyl, C 3-6 Carbocyclyl, or 3-6 membered heterocyclyl, wherein alkyl, alkoxy, alkylamino, alkenyl, alkynyl, carbocyclyl, or heterocyclyl is one or more R u It may be replaced with .

[0130] In a particular embodiment, R I1 and R I2 Each of these occurrences is independent of oxo, hydrogen, halogen, -CN, -NO2, -OH, -NH2, and C. 1-6 Alkyl, C 1-6 Alkoxy, C 1-6 Alkylamino, C 3-6 Carbocyclyl, or 3-6 membered heterocyclyl, wherein alkyl, alkoxy, alkylamino, carbocyclyl, or heterocyclyl is one or more R u It may be replaced with .

[0131] In certain embodiments, two R I1 or two R's I2 Together with the carbon atoms to which they are bonded, C 3-6Carbocyclyls (e.g., cyclopropyl (C3), cyclopropenyl (C3), cyclobutyl (C4), cyclobutenyl (C4), cyclopentyl (C5), cyclopentenyl (C5), cyclohexyl (C6), cyclohexenyl (C6), or cyclohexadienyl (C6)) or 3-6 membered heterocyclyls (e.g., heterocyclyls containing one 3-6 membered ring and 1-3 heteroatoms selected from N, O, and S), wherein the carbocyclic or heterocyclic ring contains one or more R u It may be replaced with .

[0132] In a particular embodiment, R I1’ and R I2’ Hydrogen and C are independent of each other. 1-6 Alkyl (e.g., methyl (C1), ethyl (C2), n-propyl (C3), i-propyl (C3), n-butyl (C4), i-butyl (C4), s-butyl (C4), t-butyl (C4), pentyl (C5), or hexyl (C6)), C 3-6 Carbocyclyls (e.g., cyclopropyl (C3), cyclopropenyl (C3), cyclobutyl (C4), cyclobutenyl (C4), cyclopentyl (C5), cyclopentenyl (C5), cyclohexyl (C6), cyclohexenyl (C6), or cyclohexadienyl (C6)), 3-6 membered heterocyclyls (e.g., heterocyclyls containing one 3-6 membered ring and 1-3 heteroatoms selected from N, O, and S), -S(=O)2R a -S(=O)2OR b -S(=O)2NR c R d -C(=O)R a , -C(=O)OR b , or -C(=O)NR c R d And alkyl, carbocykryl, or heterocyclyl is one or more R u It may be replaced with .

[0133] In a particular embodiment, R I1’ and R I2’ These are, independently, hydrogen or C 1-6 It is alkyl.

[0134] In a specific method of operation, each R I These are independently oxo, hydrogen, halogen (e.g., -F, -Cl, -Br, or -I), -CN, -NO2, -OH, -NH2, C 1-6 Alkyl (e.g., methyl (C1), ethyl (C2), n-propyl (C3), i-propyl (C3), n-butyl (C4), i-butyl (C4), s-butyl (C4), t-butyl (C4), pentyl (C5), or hexyl (C6)), C 1-6 Alkoxy (e.g., methoxy (C1), ethoxy (C2), propoxy (C3), i-propoxy (C3), n-butoxy (C4), i-butoxy (C4), s-butoxy (C4), t-butoxy (C4), pentoxy (C5), or hexoxy (C6)), C 1-6 Alkylaminos (e.g., dimethylamino, diethylamino, di-n-propylamino, di-i-propylamino, di-n-butylamino, di-i-butylamino, di-s-butylamino, di-t-butylamino, dipentylamino, dihexylamino, methylethylamino, methyl-n-propylamino, methyl-i-propylamino, methyl-n-butylamino, methyl-i-butylamino, methyl-s-butylamino, methyl-t-butylamino, methylpentylamino, methylhexylamino, ethyl-n-propylamino, ethyl-i-propylamino, ethyl-n-butylamino) (No, ethyl-s-butylamino, ethyl-i-butylamino, ethyl-t-butylamino, ethylpentylamino, ethylhexylamino, propyl-n-butylamino, propyl-i-butylamino, propyl-s-butylamino, propyl-t-butylamino, propylpentyrylamino, propylhexylamino, n-butylpentylamino, i-butylpentylamino, s-butylpentylamino, t-butylpentylamino, n-butylhexylamino, i-butylhexylamino, s-butylhexylamino, t-butylpentylamino, n-butylhexylamino, i-butylhexylamino, s-butylhexylamino, t-butylhexylamino, or pentylhexylamino), C 2-6Alkenyls (e.g., etenyl (C2), 1-propenyl (C3), 2-propenyl (C3), 1-butenyl (C4), 2-butenyl (C4), butadienyl (C4), pentenyl (C5), pentadienyl (C5), or hexenyl (C6)), C 2-6 Alkynnyl (e.g., ethinyl (C2), 1-propynyl (C3), 2-propynyl (C3), 1-butynyl (C4), 2-butynyl (C4), pentynyl (C5), or hexynyl (C6)), C 3-12 Carbocyclyl (e.g., cyclopropyl (C3), cyclopropenyl (C3), cyclobutyl (C4), cyclobutenyl (C4), cyclopentyl (C5), cyclopentenyl (C5), cyclohexyl (C6), cyclohexenyl (C6), cyclohexadienyl (C6), cycloheptyl (C7), cycloheptenyl (C7), cycloheptadienyl (C7), cycloheptatrienyl (C7), cyclooctyl (C8), cyclooctenyl (C8), bicyclo[2.2.1]heptanyl (C7), bicyclo[2.2.2]octanyl (C8), cyclononyl (C9), cyclononenyl (C9), cyclodecyl (C) 10 ), cyclodecenyl (C 10 ), octahydro-1H-indenyl (C9), decahydronaphthalenyl (C9) 10 ), or spiro[4.5]decanil(C 10 )), 3-12 membered heterocyclines (e.g., heterocyclines containing one or two 3-8 membered rings and 1-5 heteroatoms selected from N, O, and S), C 6-10 Aryl (e.g., phenyl or naphthyl), 5-10 membered heteroaryl (e.g., heteroaryl containing one or two 5 or 6 membered rings and 1-5 heteroatoms selected from N, O, and S), -SR b -S(=O)R a -S(=O)2R a -S(=O)2OR b -S(=O)2NR c R d , -NR c S(=O)2R a , -NR c S(=O)R a, -NR c S(=O)2OR b , -NR c S(=O)2NR c R d , -NR b C(=O)NR c R d , -NR b C(=O)R a , -NR b C(=O)OR b -OS(=O)2R a -OS(=O)2OR b -OS(=O)2NR c R d -OC(=O)R a , -OC(=O)OR b -OC(=O)NR c R d -C(=O)R a , -C(=O)OR b , or -C(=O)NR c R d Alkyl, alkoxy, alkylamino, alkenyl, alkynyl, carbocykyl, heterocyclyl, aryl, or heteroaryl is one or more R u It may be replaced with .

[0135] In a specific method of operation, each R I These are independently oxo, hydrogen, halogen, -CN, -NO2, -OH, -NH2, C 1-6 Alkyl, C 1-6 Alkoxy, C 1-6 Alkylamino, C 2-6 Alkenil, C 2-6 Alkinyl, C 3-12 Carbocyclyl, 3-12 member heterocyclyl, C 6-10 The aryl or 5-10 membered heteroaryl is an alkyl, alkoxy, alkylamino, alkenyl, alkynyl, carbocykrill, heterocyclyl, aryl, or heteroaryl, which has one or more R u It may be replaced with .

[0136] In a specific method of operation, each R IThese are independently oxo, hydrogen, deuterium, halogen, -CN, -NO2, -OH, -NH2, C 1-6 Alkyl, C 1-6 Alkoxy, C 1-6 Alkylamino, C 2-6 Alkenil, C 2-6 Alkinyl, C 3-6 Carbocyclyl, 3-6 membered heterocyclyl, C6 aryl, or 5-6 membered heteroaryl, and alkyl, alkoxy, alkylamino, alkenyl, alkynyl, carbocykrill, heterocyclyl, aryl, or heteroaryl is one or more R u It may be replaced with .

[0137] In a specific method of operation, each R I These are independently oxo, hydrogen, halogen, -CN, -NO2, -OH, -NH2, C 1-6 Alkyl, C 1-6 Alkoxy, C 1-6 Alkylamino, C 2-6 Alkenil, C 2-6 Alkinyl, C 3-6 Carbocyclyl, or 3-6 membered heterocyclyl, wherein alkyl, alkoxy, alkylamino, alkenyl, alkynyl, carbocyclyl, or heterocyclyl is one or more R u It may be replaced with .

[0138] In a specific method of operation, each R I C 1-6 It is alkyl. In certain embodiments, at least one R I C 1-6 It is alkyl.

[0139] In a specific method of operation, each R I These are independently oxo, hydrogen, halogen, -CN, -NO2, -OH, -NH2, C 1-6 Alkyl, C 1-6 Alkoxy, C 1-6 Alkylamino, C 3-6Carbocyclyl, or 3-6 membered heterocyclyl, wherein alkyl, alkoxy, alkylamino, carbocyclyl, or heterocyclyl is one or more R u It may be replaced with .

[0140] In certain embodiments, i is an integer selected from 0 to 4. In certain embodiments, i is 0. In certain embodiments, i is 1. In certain embodiments, i is 2. In certain embodiments, i is 3. In certain embodiments, i is 4.

[0141] In a particular embodiment, J 1 is N or CR J1 That is the case.

[0142] In a particular embodiment, J 2 is N or CR J2 That is the case.

[0143] In a particular embodiment, R J1 , R J2 , and R J3 These are independently hydrogen, halogens (e.g., -F, -Cl, -Br, or -I), -CN, -NO2, -OH, -NH2, C 1-6 Alkyl (e.g., methyl (C1), ethyl (C2), n-propyl (C3), i-propyl (C3), n-butyl (C4), i-butyl (C4), s-butyl (C4), t-butyl (C4), pentyl (C5), hexyl (C6)), C 1-6 Alkoxy (e.g., methoxy (C1), ethoxy (C2), propoxy (C3), i-propoxy (C3), n-butoxy (C4), i-butoxy (C4), s-butoxy (C4), t-butoxy (C4), pentoxy (C5), or hexoxy (C6)), C 1-6Alkylaminos (e.g., dimethylamino, diethylamino, di-n-propylamino, di-i-propylamino, di-n-butylamino, di-i-butylamino, di-s-butylamino, di-t-butylamino, dipentylamino, dihexylamino, methylethylamino, methyl-n-propylamino, methyl-i-propylamino, methyl-n-butylamino, methyl-i-butylamino, methyl-s-butylamino, methyl-t-butylamino, methylpentylamino, methylhexylamino, ethyl-n-propylamino, ethyl-i-propylamino, ethyl-n-butylamino) (No, ethyl-s-butylamino, ethyl-i-butylamino, ethyl-t-butylamino, ethylpentylamino, ethylhexylamino, propyl-n-butylamino, propyl-i-butylamino, propyl-s-butylamino, propyl-t-butylamino, propylpentyrylamino, propylhexylamino, n-butylpentylamino, i-butylpentylamino, s-butylpentylamino, t-butylpentylamino, n-butylhexylamino, i-butylhexylamino, s-butylhexylamino, t-butylpentylamino, n-butylhexylamino, i-butylhexylamino, s-butylhexylamino, t-butylhexylamino, or pentylhexylamino), C 2-6 Alkenyls (e.g., etenyl (C2), 1-propenyl (C3), 2-propenyl (C3), 1-butenyl (C4), 2-butenyl (C4), butadienyl (C4), pentenyl (C5), pentadienyl (C5), or hexenyl (C6)), C 2-6 Alkynnyl (e.g., ethinyl (C2), 1-propynyl (C3), 2-propynyl (C3), 1-butynyl (C4), 2-butynyl (C4), pentynyl (C5), or hexynyl (C6)), C 3-12Carbocyclyl (e.g., cyclopropyl (C3), cyclopropenyl (C3), cyclobutyl (C4), cyclobutenyl (C4), cyclopentyl (C5), cyclopentenyl (C5), cyclohexyl (C6), cyclohexenyl (C6), cyclohexadienyl (C6), cycloheptyl (C7), cycloheptenyl (C7), cycloheptadienyl (C7), cycloheptatrienyl (C7), cyclooctyl (C8), cyclooctenyl (C8), bicyclo[2.2.1]heptanyl (C7), bicyclo[2.2.2]octanyl (C8), cyclononyl (C9), cyclononenyl (C9), cyclodecyl (C) 10 ), cyclodecenyl (C 10 ), octahydro-1H-indenyl (C9), decahydronaphthalenyl (C9) 10 ), or spiro[4.5]decanil(C 10 )), 3-12 membered heterocyclines (e.g., heterocyclines containing one or two 3-8 membered rings and 1-5 heteroatoms selected from N, O, and S), C 6-10 Aryl (e.g., phenyl or naphthyl), 5-10 membered heteroaryl (e.g., heteroaryl containing one or two 5 or 6 membered rings and 1-5 heteroatoms selected from N, O, and S), -SR b -S(=O)R a -S(=O)2R a -S(=O)2OR b -S(=O)2NR c R d , -NR c S(=O)2R a , -NR c S(=O)R a , -NR c S(=O)2OR b , -NR c S(=O)2NR c R d , -NR b C(=O)NR c R d , -NR b C(=O)R a , -NR b C(=O)OR b -OS(=O)2Ra -OS(=O)2OR b -OS(=O)2NR c R d -OC(=O)R a , -OC(=O)OR b -OC(=O)NR c R d -C(=O)R a , -C(=O)OR b , or -C(=O)NR c R d Alkyl, alkoxy, alkylamino, alkenyl, alkynyl, carbocykyl, heterocyclyl, aryl, or heteroaryl is one or more R u It may be replaced with .

[0144] In a particular embodiment, R J1 , R J2 , and R J3 These are independently hydrogen, halogen, -CN, -NO2, -OH, -NH2, C 1-6 Alkyl, C 1-6 Alkoxy, C 1-6 Alkylamino, C 2-6 Alkenil, C 2-6 Alkinyl, C 3-12 Carbocyclyl, 3-12 member heterocyclyl, C 6-10 The aryl or 5-10 membered heteroaryl is an alkyl, alkoxy, alkylamino, alkenyl, alkynyl, carbocykrill, heterocyclyl, aryl, or heteroaryl, which has one or more R u It may be replaced with .

[0145] In a particular embodiment, R J1 , R J2 , and R J3 These are independently hydrogen, halogen, -CN, -NO2, -OH, -NH2, C 1-6 Alkyl, C 1-6 Alkoxy, C 1-6 Alkylamino, C 2-6 Alkenil, C 2-6 Alkinyl, C 3-6Carbocyclyl, 3-6 membered heterocyclyl, C6 aryl, or 5-6 membered heteroaryl, and alkyl, alkoxy, alkylamino, alkenyl, alkynyl, carbocykrill, heterocyclyl, aryl, or heteroaryl is one or more R u It may be replaced with .

[0146] In a particular embodiment, R J1 , R J2 , and R J3 These are independently hydrogen, halogen, -CN, -NO2, -OH, -NH2, C 1-6 Alkyl, C 1-6 Alkoxy, C 1-6 Alkylamino, C 2-6 Alkenil, C 2-6 Alkinyl, C 3-6 Carbocyclyl, or 3-6 membered heterocyclyl, wherein alkyl, alkoxy, alkylamino, alkenyl, alkynyl, carbocyclyl, or heterocyclyl is one or more R u It may be replaced with .

[0147] In a particular embodiment, R J1 , R J2 , and R J3 These are independently hydrogen, halogen, -CN, -NO2, -OH, -NH2, C 1-6 Alkyl, C 1-6 Alkoxy, C 1-6 Alkylamino, C 3-6 Carbocyclyl, or 3-6 membered heterocyclyl, wherein alkyl, alkoxy, alkylamino, carbocyclyl, or heterocyclyl is one or more R u It may be replaced with .

[0148] In a particular embodiment, R J3 Hydrogen, halogen, C 1-6 Alkyl, 3-12 member heterocyclyl, 5-10 member heteroaryl, or -C(=O)NR c R d Alkyl, heterocyclyl, or heteroaryl is one or more R uIt may be replaced with .

[0149] In a particular embodiment, R J1 and R J2 It is independently of hydrogen, or one or more R u Even if replaced by C 1-6 It is alkyl.

[0150] In a particular embodiment, T is the expression in formula I-3-iv, TIFF2026521988000167.tif21128 formula, M 1 is N or C, M 2 teeth, TIFF2026521988000168.tif10128, N, or CR M2 And, M 3 teeth, TIFF2026521988000169.tif10128, N, or CR M3 And, M 4 teeth, TIFF2026521988000170.tif10128, N, or CR M4 And, During the ceremony, TIFF2026521988000171.tif8128 shows adhesion to L, M 1 M 2 M 3 , and M 4 At least one of them is N or The filename is TIFF2026521988000172.tif8128. R M2 , R M3 , and R M4 These are independently hydrogen, halogen, -CN, -NO2, -OH, -NH2, C 1-6 Alkyl, C 1-6 Alkoxy, C 1-6 Alkylamino, C 2-6 Alkenil, C 2-6 Alkinyl, C 3-12Carbocyclyl, 3-12 member heterocyclyl, C 6-10 Aryl, 5-10 member heteroaryl, -SR b -S(=O)R a -S(=O)2R a -S(=O)2OR b -S(=O)2NR c R d , -NR c S(=O)2R a , -NR c S(=O)R a , -NR c S(=O)2OR b , -NR c S(=O)2NR c R d , -NR b C(=O)NR c R d , -NR b C(=O)R a , -NR b C(=O)OR b -OS(=O)2R a -OS(=O)2OR b -OS(=O)2NR c R d -OC(=O)R a , -OC(=O)OR b -OC(=O)NR c R d -C(=O)R a , -C(=O)OR b , or -C(=O)NR c R d Alkyl, alkoxy, alkylamino, alkenyl, alkynyl, carbocykyl, heterocyclyl, aryl, or heteroaryl is one or more R u It may also be replaced with R K’ is hydrogen, C 1-6 Alkyl, C 2-6 Alkenil, C 2-6 Alkinyl, C 3-12 Carbocyclyl, 3-12 member heterocyclyl, C 6-10 Aryl, 5-10 member heteroaryl, -S(=O)2R a -S(=O)2ORb -S(=O)2NR c R d -C(=O)R a , -C(=O)OR b , or -C(=O)NR c R d Alkyl, alkenyl, alkynyl, carbocykyl, heterocyclyl, aryl, or heteroaryl is one or more R u It may also be replaced with K 1 is -C(=O)- or -C(R K1 )2-, Each R K1 These are independently hydrogen, halogen, -CN, -NO2, -OH, -NH2, C 1-6 Alkyl, C 1-6 Alkoxy, C 1-6 Alkylamino, C 2-6 Alkenil, C 2-6 Alkinyl, C 3-12 Carbocyclyl, 3-12 member heterocyclyl, C 6-10 The aryl or 5-10 membered heteroaryl is an alkyl, alkoxy, alkylamino, alkenyl, alkynyl, carbocykrill, heterocyclyl, aryl, or heteroaryl, which has one or more R u It may also be replaced with Each R K These are independently oxo, hydrogen, halogen, -CN, -NO2, -OH, -NH2, C 1-6 Alkyl, C 1-6 Alkoxy, C 1-6 Alkylamino, C 2-6 Alkenil, C 2-6 Alkinyl, C 3-12 Carbocyclyl, 3-12 member heterocyclyl, C 6-10 Aryl, 5-10 member heteroaryl, -SR b -S(=O)R a -S(=O)2R a -S(=O)2OR b -S(=O)2NR c R d , -NR c S(=O)2R a , -NRc S(=O)R a , -NR c S(=O)2OR b , -NR c S(=O)2NR c R d , -NR b C(=O)NR c R d , -NR b C(=O)R a , -NR b C(=O)OR b -OS(=O)2R a -OS(=O)2OR b -OS(=O)2NR c R d -OC(=O)R a , -OC(=O)OR b -OC(=O)NR c R d -C(=O)R a , -C(=O)OR b , or -C(=O)NR c R d Alkyl, alkoxy, alkylamino, alkenyl, alkynyl, carbocykyl, heterocyclyl, aryl, or heteroaryl is one or more R u It may also be replaced with k is an integer selected from 0 to 4.

[0151] In a particular embodiment, T is the expression in formula I-3-iv-a. TIFF2026521988000173.tif30128

[0152] In certain embodiments, T is the expression in formula I-3-iv-b. TIFF2026521988000174.tif33128

[0153] In a particular embodiment, M 1 It is either N or C.

[0154] In a particular embodiment, M 2 teeth, TIFF2026521988000175.tif10128, N, or CR M2 That is the case.

[0155] In a particular embodiment, M 3 teeth, TIFF2026521988000176.tif10128, N, or CR M3 That is the case.

[0156] In a particular embodiment, M 3 It is N.

[0157] In a particular embodiment, M 4 teeth, TIFF2026521988000177.tif10128, N, or CR M4 That is the case.

[0158] In a particular embodiment, M 1 M 2 M 3 , and M 4 At least one of them is N or The filename is TIFF2026521988000178.tif8128.

[0159] In a particular embodiment, M 1 M 3 , and M 4 At least two of these are N. In certain embodiments, M 1 M 3 , and M 4 At least one of them is N.

[0160] In a particular embodiment, R M2 , R M3 , and R M4 These are independently hydrogen, halogens (e.g., -F, -Cl, -Br, or -I), -CN, -NO2, -OH, -NH2, C 1-6Alkyl (e.g., methyl (C1), ethyl (C2), n-propyl (C3), i-propyl (C3), n-butyl (C4), i-butyl (C4), s-butyl (C4), t-butyl (C4), pentyl (C5), or hexyl (C6)), C 1-6 Alkoxy (e.g., methoxy (C1), ethoxy (C2), propoxy (C3), i-propoxy (C3), n-butoxy (C4), i-butoxy (C4), s-butoxy (C4), t-butoxy (C4), pentoxy (C5), or hexoxy (C6)), C 1-6 Alkylaminos (e.g., dimethylamino, diethylamino, di-n-propylamino, di-i-propylamino, di-n-butylamino, di-i-butylamino, di-s-butylamino, di-t-butylamino, dipentylamino, dihexylamino, methylethylamino, methyl-n-propylamino, methyl-i-propylamino, methyl-n-butylamino, methyl-i-butylamino, methyl-s-butylamino, methyl-t-butylamino, methylpentylamino, methylhexylamino, ethyl-n-propylamino, ethyl-i-propylamino, ethyl-n-butylamino) (No, ethyl-s-butylamino, ethyl-i-butylamino, ethyl-t-butylamino, ethylpentylamino, ethylhexylamino, propyl-n-butylamino, propyl-i-butylamino, propyl-s-butylamino, propyl-t-butylamino, propylpentyrylamino, propylhexylamino, n-butylpentylamino, i-butylpentylamino, s-butylpentylamino, t-butylpentylamino, n-butylhexylamino, i-butylhexylamino, s-butylhexylamino, t-butylpentylamino, n-butylhexylamino, i-butylhexylamino, s-butylhexylamino, t-butylhexylamino, or pentylhexylamino), C 2-6 Alkenyls (e.g., etenyl (C2), 1-propenyl (C3), 2-propenyl (C3), 1-butenyl (C4), 2-butenyl (C4), butadienyl (C4), pentenyl (C5), pentadienyl (C5), or hexenyl (C6)), C 2-6Alkynnyl (e.g., ethinyl (C2), 1-propynyl (C3), 2-propynyl (C3), 1-butynyl (C4), 2-butynyl (C4), pentynyl (C5), or hexynyl (C6)), C 3-12 Carbocyclyl (e.g., cyclopropyl (C3), cyclopropenyl (C3), cyclobutyl (C4), cyclobutenyl (C4), cyclopentyl (C5), cyclopentenyl (C5), cyclohexyl (C6), cyclohexenyl (C6), cyclohexadienyl (C6), cycloheptyl (C7), cycloheptenyl (C7), cycloheptadienyl (C7), cycloheptatrienyl (C7), cyclooctyl (C8), cyclooctenyl (C8), bicyclo[2.2.1]heptanyl (C7), bicyclo[2.2.2]octanyl (C8), cyclononyl (C9), cyclononenyl (C9), cyclodecyl (C) 10 ), cyclodecenyl (C 10 ), octahydro-1H-indenyl (C9), decahydronaphthalenyl (C9) 10 ), or spiro[4.5]decanil(C 10 )), 3-12 membered heterocyclines (e.g., heterocyclines containing one or two 3-8 membered rings and 1-5 heteroatoms selected from N, O, and S), C 6-10 Aryl (e.g., phenyl or naphthyl), 5-10 membered heteroaryl (e.g., heteroaryl containing one or two 5 or 6 membered rings and 1-5 heteroatoms selected from N, O, and S), -SR b -S(=O)R a -S(=O)2R a -S(=O)2OR b -S(=O)2NR c R d , -NR c S(=O)2R a , -NR c S(=O)R a , -NR c S(=O)2OR b , -NR c S(=O)2NR c R d , -NR b C(=O)NR cR d , -NR b C(=O)R a , -NR b C(=O)OR b -OS(=O)2R a -OS(=O)2OR b -OS(=O)2NR c R d -OC(=O)R a , -OC(=O)OR b -OC(=O)NR c R d -C(=O)R a , -C(=O)OR b , or -C(=O)NR c R d Alkyl, alkoxy, alkylamino, alkenyl, alkynyl, carbocykyl, heterocyclyl, aryl, or heteroaryl is one or more R u It may be replaced with .

[0161] In a particular embodiment, R M2 , R M3 , and R M4 These are independently hydrogen, halogen, -CN, -NO2, -OH, -NH2, C 1-6 Alkyl, C 1-6 Alkoxy, C 1-6 Alkylamino, C 2-6 Alkenil, C 2-6 Alkinyl, C 3-12 Carbocyclyl, 3-12 member heterocyclyl, C 6-10 The aryl or 5-10 membered heteroaryl is an alkyl, alkoxy, alkylamino, alkenyl, alkynyl, carbocykrill, heterocyclyl, aryl, or heteroaryl, which has one or more R u It may be replaced with .

[0162] In a particular embodiment, R M2 , R M3 , and R M4 These are independently hydrogen, halogen, -CN, -NO2, -OH, -NH2, C 1-6 Alkyl, C 1-6 Alkoxy, C1-6 Alkylamino, C 2-6 Alkenil, C 2-6 Alkinyl, C 3-6 Carbocyclyl, 3-6 membered heterocyclyl, C6 aryl, or 5-6 membered heteroaryl, and alkyl, alkoxy, alkylamino, alkenyl, alkynyl, carbocykrill, heterocyclyl, aryl, or heteroaryl is one or more R u It may be replaced with .

[0163] In a particular embodiment, R M2 , R M3 , and R M4 These are independently hydrogen, halogen, -CN, -NO2, -OH, -NH2, C 1-6 Alkyl, C 1-6 Alkoxy, C 1-6 Alkylamino, C 2-6 Alkenil, C 2-6 Alkinyl, C 3-6 Carbocyclyl, or 3-6 membered heterocyclyl, wherein alkyl, alkoxy, alkylamino, alkenyl, alkynyl, carbocyclyl, or heterocyclyl is one or more R u It may be replaced with .

[0164] In a particular embodiment, R M2 , R M3 , and R M4 These are independently hydrogen, halogen, -CN, -NO2, -OH, -NH2, C 1-6 Alkyl, C 1-6 Alkoxy, C 1-6 Alkylamino, C 3-6 Carbocyclyl, or 3-6 membered heterocyclyl, wherein alkyl, alkoxy, alkylamino, carbocyclyl, or heterocyclyl is one or more R u It may be replaced with .

[0165] In a particular embodiment, R M2 C 1-6 Alkyl, C 1-6Alkoxy or 3-12 membered heterocyclyl, wherein alkyl, alkoxy, or heterocyclyl is one or more R u It may be replaced with .

[0166] In a particular embodiment, R M3 It is hydrogen.

[0167] In a particular embodiment, R K’ is hydrogen, C 1-6 Alkyl (e.g., methyl (C1), ethyl (C2), n-propyl (C3), i-propyl (C3), n-butyl (C4), i-butyl (C4), s-butyl (C4), t-butyl (C4), pentyl (C5), or hexyl (C6)), C 2-6 Alkenyls (e.g., etenyl (C2), 1-propenyl (C3), 2-propenyl (C3), 1-butenyl (C4), 2-butenyl (C4), butadienyl (C4), pentenyl (C5), pentadienyl (C5), or hexenyl (C6)), C 2-6 Alkynnyl (e.g., ethinyl (C2), 1-propynyl (C3), 2-propynyl (C3), 1-butynyl (C4), 2-butynyl (C4), pentynyl (C5), or hexynyl (C6)), C 3-12 Carbocyclyl (e.g., cyclopropyl (C3), cyclopropenyl (C3), cyclobutyl (C4), cyclobutenyl (C4), cyclopentyl (C5), cyclopentenyl (C5), cyclohexyl (C6), cyclohexenyl (C6), cyclohexadienyl (C6), cycloheptyl (C7), cycloheptenyl (C7), cycloheptadienyl (C7), cycloheptatrienyl (C7), cyclooctyl (C8), cyclooctenyl (C8), bicyclo[2.2.1]heptanyl (C7), bicyclo[2.2.2]octanyl (C8), cyclononyl (C9), cyclononenyl (C9), cyclodecyl (C) 10 ), cyclodecenyl (C 10 ), octahydro-1H-indenyl (C9), decahydronaphthalenyl (C9) 10 ), or spiro[4.5]decanil(C 10)), 3-12 membered heterocyclines (e.g., heterocyclines containing one or two 3-8 membered rings and 1-5 heteroatoms selected from N, O, and S), C 6-10 Aryl (e.g., phenyl or naphthyl), 5-10 membered heteroaryl (e.g., heteroaryl containing one or two 5 or 6 membered rings and 1-5 heteroatoms selected from N, O, and S), -S(=O)2R a -S(=O)2OR b -S(=O)2NR c R d -C(=O)R a , -C(=O)OR b , or -C(=O)NR c R d Alkyl, alkenyl, alkynyl, carbocykyl, heterocyclyl, aryl, or heteroaryl is one or more R u It may be replaced with .

[0168] In a particular embodiment, R K’ is hydrogen, C 1-6 Alkyl, C 2-6 Alkenil, C 2-6 Alkinyl, C 3-6 Carbocyclyl, 3-6 membered heterocyclyl, C6 aryl, 5-6 membered heteroaryl, -S(=O)2R a -S(=O)2OR b -S(=O)2NR c R d -C(=O)R a , -C(=O)OR b , or -C(=O)NR c R d Alkyl, alkenyl, alkynyl, carbocykyl, heterocyclyl, aryl, or heteroaryl is one or more R u It may be replaced with .

[0169] In a particular embodiment, R K’ is hydrogen, C 1-6 Alkyl, C 2-6 Alkenil, C 2-6 Alkinyl, C 3-6Carbocyclyl, or 3-6 member heterocyclyl, -S(=O)2R a -S(=O)2OR b -S(=O)2NR c R d -C(=O)R a , -C(=O)OR b , or -C(=O)NR c R d Alkyl, alkenyl, alkynyl, carbocykyl, or heterocyclyl is one or more R u It may be replaced with .

[0170] In a particular embodiment, R K’ is hydrogen, C 1-6 Alkyl, C 3-6 Carbocyclyl, 3-6 member heterocyclyl, -S(=O)2R a -S(=O)2OR b -S(=O)2NR c R d -C(=O)R a , -C(=O)OR b , or -C(=O)NR c R d And alkyl, carbocykryl, or heterocyclyl is one or more R u It may be replaced with .

[0171] In a particular embodiment, R K’ is hydrogen, or one or more R u Even if replaced by C 1-6 It is alkyl.

[0172] In a particular embodiment, K 1 is -C(=O)- or -C(R K1 )2-.

[0173] In a specific method of operation, each R K1 These are independently hydrogen, halogens (e.g., -F, -Cl, -Br, or -I), -CN, -NO2, -OH, -NH2, C 1-6Alkyl (e.g., methyl (C1), ethyl (C2), n-propyl (C3), i-propyl (C3), n-butyl (C4), i-butyl (C4), s-butyl (C4), t-butyl (C4), pentyl (C5), or hexyl (C6)), C 1-6 Alkoxy (e.g., methoxy (C1), ethoxy (C2), propoxy (C3), i-propoxy (C3), n-butoxy (C4), i-butoxy (C4), s-butoxy (C4), t-butoxy (C4), pentoxy (C5), or hexoxy (C6)), C 1-6 Alkylaminos (e.g., dimethylamino, diethylamino, di-n-propylamino, di-i-propylamino, di-n-butylamino, di-i-butylamino, di-s-butylamino, di-t-butylamino, dipentylamino, dihexylamino, methylethylamino, methyl-n-propylamino, methyl-i-propylamino, methyl-n-butylamino, methyl-i-butylamino, methyl-s-butylamino, methyl-t-butylamino, methylpentylamino, methylhexylamino, ethyl-n-propylamino, ethyl-i-propylamino, ethyl-n-butylamino) (No, ethyl-s-butylamino, ethyl-i-butylamino, ethyl-t-butylamino, ethylpentylamino, ethylhexylamino, propyl-n-butylamino, propyl-i-butylamino, propyl-s-butylamino, propyl-t-butylamino, propylpentyrylamino, propylhexylamino, n-butylpentylamino, i-butylpentylamino, s-butylpentylamino, t-butylpentylamino, n-butylhexylamino, i-butylhexylamino, s-butylhexylamino, t-butylpentylamino, n-butylhexylamino, i-butylhexylamino, s-butylhexylamino, t-butylhexylamino, or pentylhexylamino), C 2-6 Alkenyls (e.g., etenyl (C2), 1-propenyl (C3), 2-propenyl (C3), 1-butenyl (C4), 2-butenyl (C4), butadienyl (C4), pentenyl (C5), pentadienyl (C5), or hexenyl (C6)), C 2-6Alkynnyl (e.g., ethinyl (C2), 1-propynyl (C3), 2-propynyl (C3), 1-butynyl (C4), 2-butynyl (C4), pentynyl (C5), or hexynyl (C6)), C 3-12 Carbocyclyl (e.g., cyclopropyl (C3), cyclopropenyl (C3), cyclobutyl (C4), cyclobutenyl (C4), cyclopentyl (C5), cyclopentenyl (C5), cyclohexyl (C6), cyclohexenyl (C6), cyclohexadienyl (C6), cycloheptyl (C7), cycloheptenyl (C7), cycloheptadienyl (C7), cycloheptatrienyl (C7), cyclooctyl (C8), cyclooctenyl (C8), bicyclo[2.2.1]heptanyl (C7), bicyclo[2.2.2]octanyl (C8), cyclononyl (C9), cyclononenyl (C9), cyclodecyl (C) 10 ), cyclodecenyl (C 10 ), octahydro-1H-indenyl (C9), decahydronaphthalenyl (C9) 10 ), or spiro[4.5]decanil(C 10 )), 3-12 membered heterocyclines (e.g., heterocyclines containing one or two 3-8 membered rings and 1-5 heteroatoms selected from N, O, and S), C 6-10 The aryl (e.g., phenyl or naphthyl) or 5-10 membered heteroaryl (e.g., a heteroaryl containing one or two 5 or 6 membered rings and 1-5 heteroatoms selected from N, O, and S) is an alkyl, alkoxy, alkylamino, alkenyl, alkynyl, carbocykryl, heterocyclyl, aryl, or heteroaryl, which has one or more R u It may be replaced with .

[0174] In a specific method of operation, each R K1 These are independently oxo, hydrogen, halogen, -CN, -NO2, -OH, -NH2, C 1-6 Alkyl, C 1-6 Alkoxy, C 1-6 Alkylamino, C 2-6 Alkenil, C 2-6 Alkinyl, C 3-6Carbocyclyl, 3-6 membered heterocyclyl, C6 aryl, 5-6 membered heteroaryl, and alkyl, alkoxy, alkylamino, alkenyl, alkynyl, carbocykrill, heterocyclyl, aryl, or heteroaryl may be one or more R u It may be replaced with .

[0175] In a specific method of operation, each R K1 These are independently hydrogen, halogen, -CN, -NO2, -OH, -NH2, C 1-6 Alkyl, C 1-6 Alkoxy, C 1-6 Alkylamino, C 2-6 Alkenil, C 2-6 Alkinyl, C 3-6 Carbocyclyl, or 3-6 membered heterocyclyl, wherein alkyl, alkoxy, alkylamino, alkenyl, alkynyl, carbocyclyl, or heterocyclyl is one or more R u It may be replaced with .

[0176] In a specific method of operation, each R K1 These are independently hydrogen, halogen, -CN, -NO2, -OH, -NH2, C 1-6 Alkyl, C 1-6 Alkoxy, C 1-6 Alkylamino, C 3-6 Carbocyclyl, or 3-6 membered heterocyclyl, wherein alkyl, alkoxy, alkylamino, carbocyclyl, or heterocyclyl is one or more R u It may be replaced with .

[0177] In a specific method of operation, each R K These are independently oxo, hydrogen, halogen (e.g., -F, -Cl, -Br, or -I), -CN, -NO2, -OH, -NH2, C 1-6 Alkyl (e.g., methyl (C1), ethyl (C2), n-propyl (C3), i-propyl (C3), n-butyl (C4), i-butyl (C4), s-butyl (C4), t-butyl (C4), pentyl (C5), or hexyl (C6)), C 1-6Alkoxy (e.g., methoxy (C1), ethoxy (C2), propoxy (C3), i-propoxy (C3), n-butoxy (C4), i-butoxy (C4), s-butoxy (C4), t-butoxy (C4), pentoxy (C5), or hexoxy (C6)), C 1-6 Alkylaminos (e.g., dimethylamino, diethylamino, di-n-propylamino, di-i-propylamino, di-n-butylamino, di-i-butylamino, di-s-butylamino, di-t-butylamino, dipentylamino, dihexylamino, methylethylamino, methyl-n-propylamino, methyl-i-propylamino, methyl-n-butylamino, methyl-i-butylamino, methyl-s-butylamino, methyl-t-butylamino, methylpentylamino, methylhexylamino, ethyl-n-propylamino, ethyl-i-propylamino, ethyl-n-butylamino) (No, ethyl-s-butylamino, ethyl-i-butylamino, ethyl-t-butylamino, ethylpentylamino, ethylhexylamino, propyl-n-butylamino, propyl-i-butylamino, propyl-s-butylamino, propyl-t-butylamino, propylpentyrylamino, propylhexylamino, n-butylpentylamino, i-butylpentylamino, s-butylpentylamino, t-butylpentylamino, n-butylhexylamino, i-butylhexylamino, s-butylhexylamino, t-butylpentylamino, n-butylhexylamino, i-butylhexylamino, s-butylhexylamino, t-butylhexylamino, or pentylhexylamino), C 2-6 Alkenyls (e.g., etenyl (C2), 1-propenyl (C3), 2-propenyl (C3), 1-butenyl (C4), 2-butenyl (C4), butadienyl (C4), pentenyl (C5), pentadienyl (C5), or hexenyl (C6)), C 2-6 Alkynnyl (e.g., ethinyl (C2), 1-propynyl (C3), 2-propynyl (C3), 1-butynyl (C4), 2-butynyl (C4), pentynyl (C5), or hexynyl (C6)), C 3-12Carbocyclyl (e.g., cyclopropyl (C3), cyclopropenyl (C3), cyclobutyl (C4), cyclobutenyl (C4), cyclopentyl (C5), cyclopentenyl (C5), cyclohexyl (C6), cyclohexenyl (C6), cyclohexadienyl (C6), cycloheptyl (C7), cycloheptenyl (C7), cycloheptadienyl (C7), cycloheptatrienyl (C7), cyclooctyl (C8), cyclooctenyl (C8), bicyclo[2.2.1]heptanyl (C7), bicyclo[2.2.2]octanyl (C8), cyclononyl (C9), cyclononenyl (C9), cyclodecyl (C) 10 ), cyclodecenyl (C 10 ), octahydro-1H-indenyl (C9), decahydronaphthalenyl (C9) 10 ), or spiro[4.5]decanil(C 10 )), 3-12 membered heterocyclines (e.g., heterocyclines containing one or two 3-8 membered rings and 1-5 heteroatoms selected from N, O, and S), C 6-10 Aryl (e.g., phenyl or naphthyl), 5-10 membered heteroaryl (e.g., heteroaryl containing one or two 5 or 6 membered rings and 1-5 heteroatoms selected from N, O, and S), -SR b -S(=O)R a -S(=O)2R a -S(=O)2OR b -S(=O)2NR c R d , -NR c S(=O)2R a , -NR c S(=O)R a , -NR c S(=O)2OR b , -NR c S(=O)2NR c R d , -NR b C(=O)NR c R d , -NR b C(=O)R a , -NR b C(=O)OR b -OS(=O)2Ra -OS(=O)2OR b -OS(=O)2NR c R d -OC(=O)R a , -OC(=O)OR b -OC(=O)NR c R d -C(=O)R a , -C(=O)OR b , or -C(=O)NR c R d Alkyl, alkoxy, alkylamino, alkenyl, alkynyl, carbocykyl, heterocyclyl, aryl, or heteroaryl is one or more R u It may be replaced with .

[0178] In a specific method of operation, each R K These are independently oxo, hydrogen, halogen, -CN, -NO2, -OH, -NH2, C 1-6 Alkyl, C 1-6 Alkoxy, C 1-6 Alkylamino, C 2-6 Alkenil, C 2-6 Alkinyl, C 3-12 Carbocyclyl, 3-12 member heterocyclyl, C 6-10 The aryl or 5-10 membered heteroaryl is an alkyl, alkoxy, alkylamino, alkenyl, alkynyl, carbocykrill, heterocyclyl, aryl, or heteroaryl, which has one or more R u It may be replaced with .

[0179] In a specific method of operation, each R K These are independently oxo, hydrogen, halogen, -CN, -NO2, -OH, -NH2, C 1-6 Alkyl, C 1-6 Alkoxy, C 1-6 Alkylamino, C 2-6 Alkenil, C 2-6 Alkinyl, C 3-6Carbocyclyl, 3-6 membered heterocyclyl, C6 aryl, 5-6 membered heteroaryl, and alkyl, alkoxy, alkylamino, alkenyl, alkynyl, carbocykrill, heterocyclyl, aryl, or heteroaryl may be one or more R u It may be replaced with .

[0180] In a specific method of operation, each R K These are independently oxo, hydrogen, halogen, -CN, -NO2, -OH, -NH2, C 1-6 Alkyl, C 1-6 Alkoxy, C 1-6 Alkylamino, C 2-6 Alkenil, C 2-6 Alkinyl, C 3-6 Carbocyclyl, or 3-6 membered heterocyclyl, wherein alkyl, alkoxy, alkylamino, alkenyl, alkynyl, carbocyclyl, or heterocyclyl is one or more R u It may be replaced with .

[0181] In a specific method of operation, each R K These are independently oxo, hydrogen, halogen, -CN, -NO2, -OH, -NH2, C 1-6 Alkyl, C 1-6 Alkoxy, C 1-6 Alkylamino, C 3-6 Carbocyclyl, or 3-6 membered heterocyclyl, wherein alkyl, alkoxy, alkylamino, carbocyclyl, or heterocyclyl is one or more R u It may be replaced with .

[0182] In a specific method of operation, each R K These are, independently, hydrogen or C 1-6 It is alkyl. In certain embodiments, at least one R K is hydrogen. In certain embodiments, at least one R K C 1-6 It is alkyl.

[0183] In a particular embodiment, one R KIt is hydrogen, and the other is Geminal R K is C 1-6 It is alkyl.

[0184] In certain embodiments, k is an integer selected from 0 to 4. In certain embodiments, k is 0. In certain embodiments, k is 1. In certain embodiments, k is 2. In certain embodiments, k is 3. In certain embodiments, k is 4.

[0185] In a particular embodiment, T is the expression in formula I-3-iv-a-1. TIFF2026521988000179.tif30128

[0186] In certain embodiments, T is The filename is TIFF2026521988000180.tif20128.

[0187] In a particular embodiment, T is the expression in formula I-3-v, TIFF2026521988000181.tif25128In formula, P 1 teeth, TIFF2026521988000182.tif10128, N, or CR P1 And, P 2 teeth, TIFF2026521988000183.tif10128, N, or CR P2 And, TIFF2026521988000184.tif8128 shows adhesion to L, Each R N These are independently oxo, halogen, -CN, -NO2, -OH, -NH2, C 1-6 Alkyl, C 1-6 Alkoxy, C 1-6 Alkylamino, C 2-6 Alkenil, C 2-6 Alkinyl, C 3-12 Carbocyclyl, 3-12 member heterocyclyl, C 6-10Aryl, 5-10 member heteroaryl, -SR b -S(=O)R a -S(=O)2R a -S(=O)2OR b -S(=O)2NR c R d , -NR c S(=O)2R a , -NR c S(=O)R a , -NR c S(=O)2OR b , -NR c S(=O)2NR c R d , -NR b C(=O)NR c R d , -NR b C(=O)R a , -NR b C(=O)OR b -OS(=O)2R a -OS(=O)2OR b -OS(=O)2NR c R d -OC(=O)R a , -OC(=O)OR b -OC(=O)NR c R d -C(=O)R a , -C(=O)OR b , or -C(=O)NR c R d Alkyl, alkoxy, alkylamino, alkenyl, alkynyl, carbocykyl, heterocyclyl, aryl, or heteroaryl is one or more R u It may also be replaced with n is an integer selected from 0 to 6. R P1 , R P2 , and R P3 These are independently hydrogen, halogen, -CN, -NO2, -OH, -NH2, C 1-6 Alkyl, C 1-6 Alkoxy, C 1-6 Alkylamino, C 2-6 Alkenil, C 2-6 Alkinyl, C3-12 Carbocyclyl, 3-12 member heterocyclyl, C 6-10 Aryl, 5-10 member heteroaryl, -SR b -S(=O)R a -S(=O)2R a -S(=O)2OR b -S(=O)2NR c R d , -NR c S(=O)2R a , -NR c S(=O)R a , -NR c S(=O)2OR b , -NR c S(=O)2NR c R d , -NR b C(=O)NR c R d , -NR b C(=O)R a , -NR b C(=O)OR b -OS(=O)2R a -OS(=O)2OR b -OS(=O)2NR c R d -OC(=O)R a , -OC(=O)OR b -OC(=O)NR c R d -C(=O)R a , -C(=O)OR b , or -C(=O)NR c R d Alkyl, alkoxy, alkylamino, alkenyl, alkynyl, carbocykyl, heterocyclyl, aryl, or heteroaryl is one or more R u It may also be replaced with, and R 4 -OH, -NH2, C 1-6 Alkyl, C 1-6 Alkoxy, C 1-6 Alkylamino, C 2-6 Alkenil, C 2-6 Alkinyl, C 3-12 Carbocyclyl, 3-12 member heterocyclyl, C6-10 The aryl or 5-10 membered heteroaryl is an alkyl, alkoxy, alkylamino, alkenyl, alkynyl, carbocykrill, heterocyclyl, aryl, or heteroaryl, which has one or more R u It may be replaced with .

[0188] In a particular embodiment, T is the formula in equation I-3-va. TIFF2026521988000185.tif30128

[0189] In a particular embodiment, P 1 teeth, TIFF2026521988000186.tif10128, N, or CR P1 That is the case.

[0190] In a particular embodiment, P 2 teeth, TIFF2026521988000187.tif10128, N, or CR P2 That is the case.

[0191] In a specific method of operation, each R N These are independently oxo, hydrogen, halogen (e.g., -F, -Cl, -Br, or -I), -CN, -NO2, -OH, -NH2, C 1-6 Alkyl (e.g., methyl (C1), ethyl (C2), n-propyl (C3), i-propyl (C3), n-butyl (C4), i-butyl (C4), s-butyl (C4), t-butyl (C4), pentyl (C5), or hexyl (C6)), C 1-6 Alkoxy (e.g., methoxy (C1), ethoxy (C2), propoxy (C3), i-propoxy (C3), n-butoxy (C4), i-butoxy (C4), s-butoxy (C4), t-butoxy (C4), pentoxy (C5), or hexoxy (C6)), C 1-6Alkylaminos (e.g., dimethylamino, diethylamino, di-n-propylamino, di-i-propylamino, di-n-butylamino, di-i-butylamino, di-s-butylamino, di-t-butylamino, dipentylamino, dihexylamino, methylethylamino, methyl-n-propylamino, methyl-i-propylamino, methyl-n-butylamino, methyl-i-butylamino, methyl-s-butylamino, methyl-t-butylamino, methylpentylamino, methylhexylamino, ethyl-n-propylamino, ethyl-i-propylamino, ethyl-n-butylamino) (No, ethyl-s-butylamino, ethyl-i-butylamino, ethyl-t-butylamino, ethylpentylamino, ethylhexylamino, propyl-n-butylamino, propyl-i-butylamino, propyl-s-butylamino, propyl-t-butylamino, propylpentyrylamino, propylhexylamino, n-butylpentylamino, i-butylpentylamino, s-butylpentylamino, t-butylpentylamino, n-butylhexylamino, i-butylhexylamino, s-butylhexylamino, t-butylpentylamino, n-butylhexylamino, i-butylhexylamino, s-butylhexylamino, t-butylhexylamino, or pentylhexylamino), C 2-6 Alkenyls (e.g., etenyl (C2), 1-propenyl (C3), 2-propenyl (C3), 1-butenyl (C4), 2-butenyl (C4), butadienyl (C4), pentenyl (C5), pentadienyl (C5), or hexenyl (C6)), C 2-6 Alkynnyl (e.g., ethinyl (C2), 1-propynyl (C3), 2-propynyl (C3), 1-butynyl (C4), 2-butynyl (C4), pentynyl (C5), or hexynyl (C6)), C 3-12Carbocyclyl (e.g., cyclopropyl (C3), cyclopropenyl (C3), cyclobutyl (C4), cyclobutenyl (C4), cyclopentyl (C5), cyclopentenyl (C5), cyclohexyl (C6), cyclohexenyl (C6), cyclohexadienyl (C6), cycloheptyl (C7), cycloheptenyl (C7), cycloheptadienyl (C7), cycloheptatrienyl (C7), cyclooctyl (C8), cyclooctenyl (C8), bicyclo[2.2.1]heptanyl (C7), bicyclo[2.2.2]octanyl (C8), cyclononyl (C9), cyclononenyl (C9), cyclodecyl (C) 10 ), cyclodecenyl (C 10 ), octahydro-1H-indenyl (C9), decahydronaphthalenyl (C9) 10 ), or spiro[4.5]decanil(C 10 )), 3-12 membered heterocyclines (e.g., heterocyclines containing one or two 3-8 membered rings and 1-5 heteroatoms selected from N, O, and S), C 6-10 Aryl (e.g., phenyl or naphthyl), 5-10 membered heteroaryl (e.g., heteroaryl containing one or two 5 or 6 membered rings and 1-5 heteroatoms selected from N, O, and S), -SR b -S(=O)R a -S(=O)2R a -S(=O)2OR b -S(=O)2NR c R d , -NR c S(=O)2R a , -NR c S(=O)R a , -NR c S(=O)2OR b , -NR c S(=O)2NR c R d , -NR b C(=O)NR c R d , -NR b C(=O)R a , -NR b C(=O)OR b -OS(=O)2Ra -OS(=O)2OR b -OS(=O)2NR c R d -OC(=O)R a , -OC(=O)OR b -OC(=O)NR c R d -C(=O)R a , -C(=O)OR b , or -C(=O)NR c R d Alkyl, alkoxy, alkylamino, alkenyl, alkynyl, carbocykyl, heterocyclyl, aryl, or heteroaryl is one or more R u It may be replaced with .

[0192] In a specific method of operation, each R N These are independently oxo, hydrogen, halogen, -CN, -NO2, -OH, -NH2, C 1-6 Alkyl, C 1-6 Alkoxy, C 1-6 Alkylamino, C 2-6 Alkenil, C 2-6 Alkinyl, C 3-12 Carbocyclyl, 3-12 member heterocyclyl, C 6-10 The aryl or 5-10 membered heteroaryl is an alkyl, alkoxy, alkylamino, alkenyl, alkynyl, carbocykrill, heterocyclyl, aryl, or heteroaryl, which has one or more R u It may be replaced with .

[0193] In a specific method of operation, each R N These are independently oxo, hydrogen, halogen, -CN, -NO2, -OH, -NH2, C 1-6 Alkyl, C 1-6 Alkoxy, C 1-6 Alkylamino, C 2-6 Alkenil, C 2-6 Alkinyl, C 3-6Carbocyclyl, 3-6 membered heterocyclyl, C6 aryl, 5-6 membered heteroaryl, and alkyl, alkoxy, alkylamino, alkenyl, alkynyl, carbocykrill, heterocyclyl, aryl, or heteroaryl may be one or more R u It may be replaced with .

[0194] In a specific method of operation, each R N These are independently oxo, hydrogen, halogen, -CN, -NO2, -OH, -NH2, C 1-6 Alkyl, C 1-6 Alkoxy, C 1-6 Alkylamino, C 2-6 Alkenil, C 2-6 Alkinyl, C 3-6 Carbocyclyl, or 3-6 membered heterocyclyl, wherein alkyl, alkoxy, alkylamino, alkenyl, alkynyl, carbocyclyl, or heterocyclyl is one or more R u It may be replaced with .

[0195] In a specific method of operation, each R N These are independently oxo, hydrogen, halogen, -CN, -NO2, -OH, -NH2, C 1-6 Alkyl, C 1-6 Alkoxy, C 1-6 Alkylamino, C 3-6 Carbocyclyl, or 3-6 membered heterocyclyl, wherein alkyl, alkoxy, alkylamino, carbocyclyl, or heterocyclyl is one or more R u It may be replaced with .

[0196] In certain embodiments, n is an integer selected from 0 to 6. In certain embodiments, n is 0. In certain embodiments, n is 1. In certain embodiments, n is 2. In certain embodiments, n is 3. In certain embodiments, n is 4. In certain embodiments, n is 5. In certain embodiments, n is 6.

[0197] In certain embodiments, n is 0.

[0198] In a particular embodiment, R P1 , R P2 , and R P3 These are independently hydrogen, halogen, -CN, -NO2, -OH, -NH2, C 1-6 Alkyl, C 1-6 Alkoxy, C 1-6 Alkylamino, C 2-6 Alkenil, C 2-6 Alkinyl, C 3-12 Carbocyclyl, 3-12 member heterocyclyl, C 6-10 Aryl, 5-10 member heteroaryl, -SR b -S(=O)R a -S(=O)2R a -S(=O)2OR b -S(=O)2NR c R d , -NR c S(=O)2R a , -NR c S(=O)R a , -NR c S(=O)2OR b , -NR c S(=O)2NR c R d , -NR b C(=O)NR c R d , -NR b C(=O)R a , -NR b C(=O)OR b -OS(=O)2R a -OS(=O)2OR b -OS(=O)2NR c R d -OC(=O)R a , -OC(=O)OR b -OC(=O)NR c R d -C(=O)R a , -C(=O)OR b , or -C(=O)NR c R dAlkyl, alkoxy, alkylamino, alkenyl, alkynyl, carbocykyl, heterocyclyl, aryl, or heteroaryl is one or more R u It may be replaced with .

[0199] In a particular embodiment, R P1 , R P2 , and R P3 These are independently hydrogen, halogens (e.g., -F, -Cl, -Br, or -I), -CN, -NO2, -OH, -NH2, C 1-6 Alkyl (e.g., methyl (C1), ethyl (C2), n-propyl (C3), i-propyl (C3), n-butyl (C4), i-butyl (C4), s-butyl (C4), t-butyl (C4), pentyl (C5), or hexyl (C6)), C 1-6 Alkoxy (e.g., methoxy (C1), ethoxy (C2), propoxy (C3), i-propoxy (C3), n-butoxy (C4), i-butoxy (C4), s-butoxy (C4), t-butoxy (C4), pentoxy (C5), or hexoxy (C6)), C 1-6Alkylaminos (e.g., dimethylamino, diethylamino, di-n-propylamino, di-i-propylamino, di-n-butylamino, di-i-butylamino, di-s-butylamino, di-t-butylamino, dipentylamino, dihexylamino, methylethylamino, methyl-n-propylamino, methyl-i-propylamino, methyl-n-butylamino, methyl-i-butylamino, methyl-s-butylamino, methyl-t-butylamino, methylpentylamino, methylhexylamino, ethyl-n-propylamino, ethyl-i-propylamino, ethyl-n-butylamino) (No, ethyl-s-butylamino, ethyl-i-butylamino, ethyl-t-butylamino, ethylpentylamino, ethylhexylamino, propyl-n-butylamino, propyl-i-butylamino, propyl-s-butylamino, propyl-t-butylamino, propylpentyrylamino, propylhexylamino, n-butylpentylamino, i-butylpentylamino, s-butylpentylamino, t-butylpentylamino, n-butylhexylamino, i-butylhexylamino, s-butylhexylamino, t-butylpentylamino, n-butylhexylamino, i-butylhexylamino, s-butylhexylamino, t-butylhexylamino, or pentylhexylamino), C 2-6 Alkenyls (e.g., etenyl (C2), 1-propenyl (C3), 2-propenyl (C3), 1-butenyl (C4), 2-butenyl (C4), butadienyl (C4), pentenyl (C5), pentadienyl (C5), or hexenyl (C6)), C 2-6 Alkynnyl (e.g., ethinyl (C2), 1-propynyl (C3), 2-propynyl (C3), 1-butynyl (C4), 2-butynyl (C4), pentynyl (C5), or hexynyl (C6)), C 3-12Carbocyclyl (e.g., cyclopropyl (C3), cyclopropenyl (C3), cyclobutyl (C4), cyclobutenyl (C4), cyclopentyl (C5), cyclopentenyl (C5), cyclohexyl (C6), cyclohexenyl (C6), cyclohexadienyl (C6), cycloheptyl (C7), cycloheptenyl (C7), cycloheptadienyl (C7), cycloheptatrienyl (C7), cyclooctyl (C8), cyclooctenyl (C8), bicyclo[2.2.1]heptanyl (C7), bicyclo[2.2.2]octanyl (C8), cyclononyl (C9), cyclononenyl (C9), cyclodecyl (C) 10 ), cyclodecenyl (C 10 ), octahydro-1H-indenyl (C9), decahydronaphthalenyl (C9) 10 ), or spiro[4.5]decanil(C 10 )), 3-12 membered heterocyclines (e.g., heterocyclines containing one or two 3-8 membered rings and 1-5 heteroatoms selected from N, O, and S), C 6-10 Aryl (e.g., phenyl or naphthyl), 5-10 membered heteroaryl (e.g., heteroaryl containing one or two 5 or 6 membered rings and 1-5 heteroatoms selected from N, O, and S), -SR b -S(=O)R a -S(=O)2R a -S(=O)2OR b -S(=O)2NR c R d , -NR c S(=O)2R a , -NR c S(=O)R a , -NR c S(=O)2OR b , -NR c S(=O)2NR c R d , -NR b C(=O)NR c R d , -NR b C(=O)R a , -NR b C(=O)OR b -OS(=O)2Ra -OS(=O)2OR b -OS(=O)2NR c R d -OC(=O)R a , -OC(=O)OR b -OC(=O)NR c R d -C(=O)R a , -C(=O)OR b , or -C(=O)NR c R d Alkyl, alkoxy, alkylamino, alkenyl, alkynyl, carbocykyl, heterocyclyl, aryl, or heteroaryl is one or more R u It may be replaced with .

[0200] In a particular embodiment, R P1 , R P2 , and R P3 These are independently hydrogen, halogen, -CN, -NO2, -OH, -NH2, C 1-6 Alkyl, C 1-6 Alkoxy, C 1-6 Alkylamino, C 2-6 Alkenil, C 2-6 Alkinyl, C 3-12 Carbocyclyl, 3-12 member heterocyclyl, C 6-10 The aryl or 5-10 membered heteroaryl is an alkyl, alkoxy, alkylamino, alkenyl, alkynyl, carbocykrill, heterocyclyl, aryl, or heteroaryl, which has one or more R u It may be replaced with .

[0201] In a particular embodiment, R P1 , R P2 , and R P3 These are independently hydrogen, halogen, -CN, -NO2, -OH, -NH2, C 1-6 Alkyl, C 1-6 Alkoxy, C 1-6 Alkylamino, C 2-6 Alkenil, C 2-6 Alkinyl, C 3-6Carbocyclyl, 3-6 membered heterocyclyl, C6 aryl, or 5-6 membered heteroaryl, and alkyl, alkoxy, alkylamino, alkenyl, alkynyl, carbocykrill, heterocyclyl, aryl, or heteroaryl is one or more R u It may be replaced with .

[0202] In a particular embodiment, R P1 , R P2 , and R P3 These are independently hydrogen, halogen, -CN, -NO2, -OH, -NH2, C 1-6 Alkyl, C 1-6 Alkoxy, C 1-6 Alkylamino, C 2-6 Alkenil, C 2-6 Alkinyl, C 3-6 Carbocyclyl, or 3-6 membered heterocyclyl, wherein alkyl, alkoxy, alkylamino, alkenyl, alkynyl, carbocyclyl, or heterocyclyl is one or more R u It may be replaced with .

[0203] In a particular embodiment, R P1 , R P2 , and R P3 These are independently hydrogen, halogen, -CN, -NO2, -OH, -NH2, C 1-6 Alkyl, C 1-6 Alkoxy, C 1-6 Alkylamino, C 3-6 Carbocyclyl, or 3-6 membered heterocyclyl, wherein alkyl, alkoxy, alkylamino, carbocyclyl, or heterocyclyl is one or more R u It may be replaced with .

[0204] In a particular embodiment, R P3 is hydrogen, C 1-6 Alkyl, C 3-12 Carbocyclyl, 3-12 member heterocyclyl, or C(=O)NR c R d And alkyl, carbocykryl, or heterocyclyl is one or more R uIt may be replaced with .

[0205] In a particular embodiment, R 4 -OH, -NH2, C 1-6 Alkyl (e.g., methyl (C1), ethyl (C2), n-propyl (C3), i-propyl (C3), n-butyl (C4), i-butyl (C4), s-butyl (C4), t-butyl (C4), pentyl (C5), or hexyl (C6)), C 1-6 Alkoxy (e.g., methoxy (C1), ethoxy (C2), propoxy (C3), i-propoxy (C3), n-butoxy (C4), i-butoxy (C4), s-butoxy (C4), t-butoxy (C4), pentoxy (C5), or hexoxy (C6)), C 1-6 Alkylaminos (e.g., dimethylamino, diethylamino, di-n-propylamino, di-i-propylamino, di-n-butylamino, di-i-butylamino, di-s-butylamino, di-t-butylamino, dipentylamino, dihexylamino, methylethylamino, methyl-n-propylamino, methyl-i-propylamino, methyl-n-butylamino, methyl-i-butylamino, methyl-s-butylamino, methyl-t-butylamino, methylpentylamino, methylhexylamino, ethyl-n-propylamino, ethyl-i-propylamino, ethyl-n-butylamino) (No, ethyl-s-butylamino, ethyl-i-butylamino, ethyl-t-butylamino, ethylpentylamino, ethylhexylamino, propyl-n-butylamino, propyl-i-butylamino, propyl-s-butylamino, propyl-t-butylamino, propylpentyrylamino, propylhexylamino, n-butylpentylamino, i-butylpentylamino, s-butylpentylamino, t-butylpentylamino, n-butylhexylamino, i-butylhexylamino, s-butylhexylamino, t-butylpentylamino, n-butylhexylamino, i-butylhexylamino, s-butylhexylamino, t-butylhexylamino, or pentylhexylamino), C 2-6Alkenyls (e.g., etenyl (C2), 1-propenyl (C3), 2-propenyl (C3), 1-butenyl (C4), 2-butenyl (C4), butadienyl (C4), pentenyl (C5), pentadienyl (C5), or hexenyl (C6)), C 2-6 Alkynnyl (e.g., ethinyl (C2), 1-propynyl (C3), 2-propynyl (C3), 1-butynyl (C4), 2-butynyl (C4), pentynyl (C5), or hexynyl (C6)), C 3-12 Carbocyclyl (e.g., cyclopropyl (C3), cyclopropenyl (C3), cyclobutyl (C4), cyclobutenyl (C4), cyclopentyl (C5), cyclopentenyl (C5), cyclohexyl (C6), cyclohexenyl (C6), cyclohexadienyl (C6), cycloheptyl (C7), cycloheptenyl (C7), cycloheptadienyl (C7), cycloheptatrienyl (C7), cyclooctyl (C8), cyclooctenyl (C8), bicyclo[2.2.1]heptanyl (C7), bicyclo[2.2.2]octanyl (C8), cyclononyl (C9), cyclononenyl (C9), cyclodecyl (C) 10 ), cyclodecenyl (C 10 ), octahydro-1H-indenyl (C9), decahydronaphthalenyl (C9) 10 ), or spiro[4.5]decanil(C 10 )), 3-12 membered heterocyclines (e.g., heterocyclines containing one or two 3-8 membered rings and 1-5 heteroatoms selected from N, O, and S), C 6-10 Aryl (e.g., phenyl or naphthyl), 5-10 membered heteroaryl (e.g., heteroaryl containing one or two 5 or 6 membered rings and 1-5 heteroatoms selected from N, O, and S), and alkyl, alkoxy, alkylamino, alkenyl, alkynyl, carbocykryl, heterocyclyl, aryl, or heteroaryl may have one or more R u It may be replaced with .

[0206] In a particular embodiment, R 4 C 1-6 Alkyl or C1-6 It is an alkylamino, and alkyl or alkylamino is one or more R u It may be replaced with .

[0207] In a particular embodiment, T is the expression in formula I-3-vi, TIFF2026521988000188.tif19128In formula, Q 1 , NR Q1’ , C(R Q1 )2, or O, R Q1’ is hydrogen, C 1-6 Alkyl, C 2-6 Alkenil, C 2-6 Alkinyl, C 3-12 Carbocyclyl, 3-12 member heterocyclyl, C 6-10 Aryl, 5-10 member heteroaryl, -S(=O)2R a -S(=O)2OR b -S(=O)2NR c R d -C(=O)R a , -C(=O)OR b , or -C(=O)NR c R d Alkyl, alkenyl, alkynyl, carbocykyl, heterocyclyl, aryl, or heteroaryl is one or more R u It may also be replaced with Each R Q1 These are independently hydrogen, halogen, -CN, -NO2, -OH, -NH2, C 1-6 Alkyl, C 1-6 Alkoxy, C 1-6 Alkylamino, C 2-6 Alkenil, C 2-6 Alkinyl, C 3-12 Carbocyclyl, 3-12 member heterocyclyl, C 6-10 The aryl or 5-10 membered heteroaryl is an alkyl, alkoxy, alkylamino, alkenyl, alkynyl, carbocykrill, heterocyclyl, aryl, or heteroaryl, which has one or more R u Is it okay if it is replaced with, or Two R's Q1 Together with the carbon atoms to which they are bonded, C 3-6 It forms a carbocyclic ring or a 3- to 6-membered heterocyclic ring, and the carbocyclic ring or heterocyclic ring has one or more R u It may also be replaced with If TIFF2026521988000189.tif1128 has a double bond, Q 2 is N or CR Q2 Q 3 is N or CR Q3 And, If TIFF2026521988000190.tif1128 is a single join, Q 2 is NR Q2’ , C(R Q2 )2, or O, Q 3 is NR Q3’ , C(R Q3 )2, or O, R Q2’ and R Q3’ These are, independently, hydrogen and C 1-6 Alkyl, C 2-6 Alkenil, C 2-6 Alkinyl, C 3-12 Carbocyclyl, 3-12 member heterocyclyl, C 6-10 Aryl, 5-10 member heteroaryl, -S(=O)2R a -S(=O)2OR b -S(=O)2NR c R d -C(=O)R a , -C(=O)OR b , or -C(=O)NR c R d Alkyl, alkenyl, alkynyl, carbocykyl, heterocyclyl, aryl, or heteroaryl is one or more R u It may also be replaced with R Q2 and R Q3 Each occurrence is independently of hydrogen, halogen, -CN, -NO2, -OH, -NH2, C 1-6 Alkyl, C 1-6 Alkoxy, C 1-6 Alkylamino, C2-6 Alkenil, C 2-6 Alkinyl, C 3-12 Carbocyclyl, 3-12 member heterocyclyl, C 6-10 The aryl or 5-10 membered heteroaryl is an alkyl, alkoxy, alkylamino, alkenyl, alkynyl, carbocykrill, heterocyclyl, aryl, or heteroaryl, which has one or more R u Is it okay if it is replaced with, or Two R's Q2 or two R's Q3 Together with the carbon atoms to which they are bonded, C 3-6 It forms a carbocyclic ring or a 3- to 6-membered heterocyclic ring, and the carbocyclic ring or heterocyclic ring has one or more R u It may also be replaced with S 1 CR S1 or N, S 2 teeth TIFF2026521988000191.tif8128,CR S2 , or N, S 3 teeth TIFF2026521988000192.tif8128,CR S3 , or N, S 4 teeth, TIFF2026521988000193.tif8128,CR S4 , or N, TIFF2026521988000194.tif8128 shows adhesion to L, and R S1 , R S2 , R S3 , and R S4 These are independently hydrogen, halogen, -CN, -NO2, -OH, -NH2, C 1-6 Alkyl, C 1-6 Alkoxy, C 1-6 Alkylamino, C 2-6 Alkenil, C 2-6 Alkinyl, C 3-12 Carbocyclyl, 3-12 member heterocyclyl, C6-10 Aryl, 5-10 member heteroaryl, -SR b -S(=O)R a -S(=O)2R a -S(=O)2OR b -S(=O)2NR c R d , -NR c S(=O)2R a , -NR c S(=O)R a , -NR c S(=O)2OR b , -NR c S(=O)2NR c R d , -NR b C(=O)NR c R d , -NR b C(=O)R a , -NR b C(=O)OR b -OS(=O)2R a -OS(=O)2OR b -OS(=O)2NR c R d -OC(=O)R a , -OC(=O)OR b -OC(=O)NR c R d -C(=O)R a , -C(=O)OR b , or -C(=O)NR c R d Alkyl, alkoxy, alkylamino, alkenyl, alkynyl, carbocykyl, heterocyclyl, aryl, or heteroaryl is one or more R u It may be replaced with .

[0208] In a particular embodiment, T is the expression in formula I-3-vi, TIFF2026521988000195.tif21128In formula, Q 1 , NR Q1’ And, R Q1’ C 1-6 It is alkyl, TIFF2026521988000196.tif1128 has a double bond, Q 2 CR Q2 And, Q 3 CR Q3 And, R Q2 and R Q3 Each occurrence is independent of hydrogen or C 1-6 It is alkyl, S 1 CR S1 or N, S 2 CR S2 And, S 3 CR S3 or N, S 4 teeth, The filename is TIFF2026521988000197.tif8128. TIFF2026521988000198.tif8128 shows adhesion to L, and R S1 , R S2 , and R S3 Hydrogen and C are independent of each other. 1-6 They are alkyl or 3- to 12-membered heterocyclines.

[0209] In certain embodiments, T is the formula I-3-vi-a or I-3-vi-b. TIFF2026521988000199.tif25128

[0210] In a particular embodiment, Q 1 , NR Q1’ , C(R Q1 )2, or O.

[0211] In a particular embodiment, R Q1’ is hydrogen, C 1-6Alkyl (e.g., methyl (C1), ethyl (C2), n-propyl (C3), i-propyl (C3), n-butyl (C4), i-butyl (C4), s-butyl (C4), t-butyl (C4), pentyl (C5), or hexyl (C6)), C 2-6 Alkenyls (e.g., etenyl (C2), 1-propenyl (C3), 2-propenyl (C3), 1-butenyl (C4), 2-butenyl (C4), butadienyl (C4), pentenyl (C5), pentadienyl (C5), or hexenyl (C6)), C 2-6 Alkynnyl (e.g., ethinyl (C2), 1-propynyl (C3), 2-propynyl (C3), 1-butynyl (C4), 2-butynyl (C4), pentynyl (C5), or hexynyl (C6)), C 3-12 Carbocyclyl (e.g., cyclopropyl (C3), cyclopropenyl (C3), cyclobutyl (C4), cyclobutenyl (C4), cyclopentyl (C5), cyclopentenyl (C5), cyclohexyl (C6), cyclohexenyl (C6), cyclohexadienyl (C6), cycloheptyl (C7), cycloheptenyl (C7), cycloheptadienyl (C7), cycloheptatrienyl (C7), cyclooctyl (C8), cyclooctenyl (C8), bicyclo[2.2.1]heptanyl (C7), bicyclo[2.2.2]octanyl (C8), cyclononyl (C9), cyclononenyl (C9), cyclodecyl (C) 10 ), cyclodecenyl (C 10 ), octahydro-1H-indenyl (C9), decahydronaphthalenyl (C9) 10 ), or spiro[4.5]decanil(C 10 )), 3-12 membered heterocyclines (e.g., heterocyclines containing one or two 3-8 membered rings and 1-5 heteroatoms selected from N, O, and S), C 6-10 Aryl (e.g., phenyl or naphthyl), 5-10 membered heteroaryl (e.g., heteroaryl containing one or two 5 or 6 membered rings and 1-5 heteroatoms selected from N, O, and S), -S(=O)2R a -S(=O)2OR b -S(=O)2NR c Rd -C(=O)R a , -C(=O)OR b , or -C(=O)NR c R d Alkyl, alkenyl, alkynyl, carbocykyl, heterocyclyl, aryl, or heteroaryl is one or more R u It may be replaced with .

[0212] In a particular embodiment, R Q1’ is hydrogen, C 1-6 Alkyl, C 2-6 Alkenil, C 2-6 Alkinyl, C 3-6 Carbocyclyl, 3-6 membered heterocyclyl, C6 aryl, 5-6 membered heteroaryl, -S(=O)2R a -S(=O)2OR b -S(=O)2NR c R d -C(=O)R a , -C(=O)OR b , or -C(=O)NR c R d Alkyl, alkenyl, alkynyl, carbocykyl, heterocyclyl, aryl, or heteroaryl is one or more R u It may be replaced with .

[0213] In a particular embodiment, R Q1’ is hydrogen, C 1-6 Alkyl, C 2-6 Alkenil, C 2-6 Alkinyl, C 3-6 Carbocyclyl, or 3-6 member heterocyclyl, -S(=O)2R a -S(=O)2OR b -S(=O)2NR c R d -C(=O)R a , -C(=O)OR b , or -C(=O)NR c R d Alkyl, alkenyl, alkynyl, carbocykyl, or heterocyclyl is one or more R uIt may be replaced with .

[0214] In a particular embodiment, R Q1’ is hydrogen, C 1-6 Alkyl, C 3-6 Carbocyclyl, 3-6 member heterocyclyl, -S(=O)2R a -S(=O)2OR b -S(=O)2NR c R d -C(=O)R a , -C(=O)OR b , or -C(=O)NR c R d And alkyl, carbocykryl, or heterocyclyl is one or more R u It may be replaced with .

[0215] In a particular embodiment, R Q1’ is hydrogen or C 1-6 It is alkyl.

[0216] In a specific method of operation, each R Q1 These are independently oxo, hydrogen, halogen (e.g., -F, -Cl, -Br, or -I), -CN, -NO2, -OH, -NH2, C 1-6 Alkyl (e.g., methyl (C1), ethyl (C2), n-propyl (C3), i-propyl (C3), n-butyl (C4), i-butyl (C4), s-butyl (C4), t-butyl (C4), pentyl (C5), or hexyl (C6)), C 1-6 Alkoxy (e.g., methoxy (C1), ethoxy (C2), propoxy (C3), i-propoxy (C3), n-butoxy (C4), i-butoxy (C4), s-butoxy (C4), t-butoxy (C4), pentoxy (C5), or hexoxy (C6)), C 1-6Alkylaminos (e.g., dimethylamino, diethylamino, di-n-propylamino, di-i-propylamino, di-n-butylamino, di-i-butylamino, di-s-butylamino, di-t-butylamino, dipentylamino, dihexylamino, methylethylamino, methyl-n-propylamino, methyl-i-propylamino, methyl-n-butylamino, methyl-i-butylamino, methyl-s-butylamino, methyl-t-butylamino, methylpentylamino, methylhexylamino, ethyl-n-propylamino, ethyl-i-propylamino, ethyl-n-butylamino) (No, ethyl-s-butylamino, ethyl-i-butylamino, ethyl-t-butylamino, ethylpentylamino, ethylhexylamino, propyl-n-butylamino, propyl-i-butylamino, propyl-s-butylamino, propyl-t-butylamino, propylpentyrylamino, propylhexylamino, n-butylpentylamino, i-butylpentylamino, s-butylpentylamino, t-butylpentylamino, n-butylhexylamino, i-butylhexylamino, s-butylhexylamino, t-butylpentylamino, n-butylhexylamino, i-butylhexylamino, s-butylhexylamino, t-butylhexylamino, or pentylhexylamino), C 2-6 Alkenyls (e.g., etenyl (C2), 1-propenyl (C3), 2-propenyl (C3), 1-butenyl (C4), 2-butenyl (C4), butadienyl (C4), pentenyl (C5), pentadienyl (C5), or hexenyl (C6)), C 2-6 Alkynnyl (e.g., ethinyl (C2), 1-propynyl (C3), 2-propynyl (C3), 1-butynyl (C4), 2-butynyl (C4), pentynyl (C5), or hexynyl (C6)), C 3-12Carbocyclyl (e.g., cyclopropyl (C3), cyclopropenyl (C3), cyclobutyl (C4), cyclobutenyl (C4), cyclopentyl (C5), cyclopentenyl (C5), cyclohexyl (C6), cyclohexenyl (C6), cyclohexadienyl (C6), cycloheptyl (C7), cycloheptenyl (C7), cycloheptadienyl (C7), cycloheptatrienyl (C7), cyclooctyl (C8), cyclooctenyl (C8), bicyclo[2.2.1]heptanyl (C7), bicyclo[2.2.2]octanyl (C8), cyclononyl (C9), cyclononenyl (C9), cyclodecyl (C) 10 ), cyclodecenyl (C 10 ), octahydro-1H-indenyl (C9), decahydronaphthalenyl (C9) 10 ), or spiro[4.5]decanil(C 10 )), 3-12 membered heterocyclines (e.g., heterocyclines containing one or two 3-8 membered rings and 1-5 heteroatoms selected from N, O, and S), C 6-10 The aryl (e.g., phenyl or naphthyl) or 5-10 membered heteroaryl (e.g., a heteroaryl containing one or two 5 or 6 membered rings and 1-5 heteroatoms selected from N, O, and S) is an alkyl, alkoxy, alkylamino, alkenyl, alkynyl, carbocykryl, heterocyclyl, aryl, or heteroaryl, which has one or more R u It may be replaced with .

[0217] In a specific method of operation, each R Q1 These are independently oxo, hydrogen, halogen, -CN, -NO2, -OH, -NH2, C 1-6 Alkyl, C 1-6 Alkoxy, C 1-6 Alkylamino, C 2-6 Alkenil, C 2-6 Alkinyl, C 3-6Carbocyclyl, 3-6 membered heterocyclyl, C6 aryl, 5-6 membered heteroaryl, and alkyl, alkoxy, alkylamino, alkenyl, alkynyl, carbocykrill, heterocyclyl, aryl, or heteroaryl may be one or more R u It may be replaced with .

[0218] In a specific method of operation, each R Q1 These are independently oxo, hydrogen, halogen, -CN, -NO2, -OH, -NH2, C 1-6 Alkyl, C 1-6 Alkoxy, C 1-6 Alkylamino, C 2-6 Alkenil, C 2-6 Alkinyl, C 3-6 Carbocyclyl, or 3-6 membered heterocyclyl, wherein alkyl, alkoxy, alkylamino, alkenyl, alkynyl, carbocyclyl, or heterocyclyl is one or more R u It may be replaced with .

[0219] In a specific method of operation, each R Q1 These are independently oxo, hydrogen, halogen, -CN, -NO2, -OH, -NH2, C 1-6 Alkyl, C 1-6 Alkoxy, C 1-6 Alkylamino, C 3-6 Carbocyclyl, or 3-6 membered heterocyclyl, wherein alkyl, alkoxy, alkylamino, carbocyclyl, or heterocyclyl is one or more R u It may be replaced with .

[0220] In certain embodiments, two R Q1 Together with the carbon atoms to which they are bonded, C 3-6Carbocyclyls (e.g., cyclopropyl (C3), cyclopropenyl (C3), cyclobutyl (C4), cyclobutenyl (C4), cyclopentyl (C5), cyclopentenyl (C5), cyclohexyl (C6), cyclohexenyl (C6), or cyclohexadienyl (C6)) or 3-6 membered heterocyclyls (e.g., heterocyclyls containing one 3-6 membered ring and 1-3 heteroatoms selected from N, O, and S), wherein the carbocyclic or heterocyclic ring contains one or more R u It may be replaced with .

[0221] In a particular embodiment, If TIFF2026521988000200.tif1128 has a double bond, Q 2 is N or CR Q2 That is the case.

[0222] In a particular embodiment, If TIFF2026521988000201.tif1128 is a single join, Q 2 is NR Q2’ , C(R Q2 )2, or O.

[0223] In a particular embodiment, R Q2’ and R Q3’ These are, independently, hydrogen and C 1-6 Alkyl (e.g., methyl (C1), ethyl (C2), n-propyl (C3), i-propyl (C3), n-butyl (C4), i-butyl (C4), s-butyl (C4), t-butyl (C4), pentyl (C5), or hexyl (C6)), C 2-6 Alkenyls (e.g., etenyl (C2), 1-propenyl (C3), 2-propenyl (C3), 1-butenyl (C4), 2-butenyl (C4), butadienyl (C4), pentenyl (C5), pentadienyl (C5), or hexenyl (C6)), C 2-6 Alkynnyl (e.g., ethinyl (C2), 1-propynyl (C3), 2-propynyl (C3), 1-butynyl (C4), 2-butynyl (C4), pentynyl (C5), or hexynyl (C6)), C 3-12Carbocyclyl (e.g., cyclopropyl (C3), cyclopropenyl (C3), cyclobutyl (C4), cyclobutenyl (C4), cyclopentyl (C5), cyclopentenyl (C5), cyclohexyl (C6), cyclohexenyl (C6), cyclohexadienyl (C6), cycloheptyl (C7), cycloheptenyl (C7), cycloheptadienyl (C7), cycloheptatrienyl (C7), cyclooctyl (C8), cyclooctenyl (C8), bicyclo[2.2.1]heptanyl (C7), bicyclo[2.2.2]octanyl (C8), cyclononyl (C9), cyclononenyl (C9), cyclodecyl (C) 10 ), cyclodecenyl (C 10 ), octahydro-1H-indenyl (C9), decahydronaphthalenyl (C9) 10 ), or spiro[4.5]decanil(C 10 )), 3-12 membered heterocyclines (e.g., heterocyclines containing one or two 3-8 membered rings and 1-5 heteroatoms selected from N, O, and S), C 6-10 Aryl (e.g., phenyl or naphthyl), 5-10 membered heteroaryl (e.g., heteroaryl containing one or two 5 or 6 membered rings and 1-5 heteroatoms selected from N, O, and S), -S(=O)2R a -S(=O)2OR b -S(=O)2NR c R d -C(=O)R a , -C(=O)OR b , or -C(=O)NR c R d Alkyl, alkenyl, alkynyl, carbocykyl, heterocyclyl, aryl, or heteroaryl is one or more R u It may be replaced with .

[0224] In a particular embodiment, R Q2’ and R Q3’ Hydrogen and C are independent of each other. 1-6 Alkyl, C 2-6 Alkenil, C 2-6 Alkinyl, C 3-6Carbocyclyl, 3-6 membered heterocyclyl, C6 aryl, 5-6 membered heteroaryl, -S(=O)2R a -S(=O)2OR b -S(=O)2NR c R d -C(=O)R a , -C(=O)OR b , or -C(=O)NR c R d Alkyl, alkenyl, alkynyl, carbocykyl, heterocyclyl, aryl, or heteroaryl is one or more R u It may be replaced with .

[0225] In a particular embodiment, R Q2’ and R Q3’ Hydrogen and C are independent of each other. 1-6 Alkyl, C 2-6 Alkenil, C 2-6 Alkinyl, C 3-6 Carbocyclyl, or 3-6 member heterocyclyl, -S(=O)2R a -S(=O)2OR b -S(=O)2NR c R d -C(=O)R a , -C(=O)OR b , or -C(=O)NR c R d Alkyl, alkenyl, alkynyl, carbocykyl, or heterocyclyl is one or more R u It may be replaced with .

[0226] In a particular embodiment, R Q2’ and R Q3’ Hydrogen and C are independent of each other. 1-6 Alkyl, C 3-6 Carbocyclyl, 3-6 member heterocyclyl, -S(=O)2R a -S(=O)2OR b -S(=O)2NR c R d -C(=O)R a , -C(=O)OR b , or -C(=O)NR c Rd And alkyl, carbocykryl, or heterocyclyl is one or more R u It may be replaced with .

[0227] In a particular embodiment, R Q2 and R Q3 Each occurrence is independently hydrogen, halogen (e.g., -F, -Cl, -Br, or -I), -CN, -NO2, -OH, -NH2, C 1-6 Alkyl (e.g., methyl (C1), ethyl (C2), n-propyl (C3), i-propyl (C3), n-butyl (C4), i-butyl (C4), s-butyl (C4), t-butyl (C4), pentyl (C5), or hexyl (C6)), C 1-6 Alkoxy (e.g., methoxy (C1), ethoxy (C2), propoxy (C3), i-propoxy (C3), n-butoxy (C4), i-butoxy (C4), s-butoxy (C4), t-butoxy (C4), pentoxy (C5), or hexoxy (C6)), C 1-6Alkylaminos (e.g., dimethylamino, diethylamino, di-n-propylamino, di-i-propylamino, di-n-butylamino, di-i-butylamino, di-s-butylamino, di-t-butylamino, dipentylamino, dihexylamino, methylethylamino, methyl-n-propylamino, methyl-i-propylamino, methyl-n-butylamino, methyl-i-butylamino, methyl-s-butylamino, methyl-t-butylamino, methylpentylamino, methylhexylamino, ethyl-n-propylamino, ethyl-i-propylamino, ethyl-n-butylamino) (No, ethyl-s-butylamino, ethyl-i-butylamino, ethyl-t-butylamino, ethylpentylamino, ethylhexylamino, propyl-n-butylamino, propyl-i-butylamino, propyl-s-butylamino, propyl-t-butylamino, propylpentyrylamino, propylhexylamino, n-butylpentylamino, i-butylpentylamino, s-butylpentylamino, t-butylpentylamino, n-butylhexylamino, i-butylhexylamino, s-butylhexylamino, t-butylpentylamino, n-butylhexylamino, i-butylhexylamino, s-butylhexylamino, t-butylhexylamino, or pentylhexylamino), C 2-6 Alkenyls (e.g., etenyl (C2), 1-propenyl (C3), 2-propenyl (C3), 1-butenyl (C4), 2-butenyl (C4), butadienyl (C4), pentenyl (C5), pentadienyl (C5), or hexenyl (C6)), C 2-6 Alkynnyl (e.g., ethinyl (C2), 1-propynyl (C3), 2-propynyl (C3), 1-butynyl (C4), 2-butynyl (C4), pentynyl (C5), or hexynyl (C6)), C 3-12Carbocyclyl (e.g., cyclopropyl (C3), cyclopropenyl (C3), cyclobutyl (C4), cyclobutenyl (C4), cyclopentyl (C5), cyclopentenyl (C5), cyclohexyl (C6), cyclohexenyl (C6), cyclohexadienyl (C6), cycloheptyl (C7), cycloheptenyl (C7), cycloheptadienyl (C7), cycloheptatrienyl (C7), cyclooctyl (C8), cyclooctenyl (C8), bicyclo[2.2.1]heptanyl (C7), bicyclo[2.2.2]octanyl (C8), cyclononyl (C9), cyclononenyl (C9), cyclodecyl (C) 10 ), cyclodecenyl (C 10 ), octahydro-1H-indenyl (C9), decahydronaphthalenyl (C9) 10 ), or spiro[4.5]decanil(C 10 )), 3-12 membered heterocyclines (e.g., heterocyclines containing one or two 3-8 membered rings and 1-5 heteroatoms selected from N, O, and S), C 6-10 The aryl (e.g., phenyl or naphthyl) or 5-10 membered heteroaryl (e.g., a heteroaryl containing one or two 5 or 6 membered rings and 1-5 heteroatoms selected from N, O, and S) is an alkyl, alkoxy, alkylamino, alkenyl, alkynyl, carbocykryl, heterocyclyl, aryl, or heteroaryl, which has one or more R u It may be replaced with .

[0228] In a particular embodiment, R Q2 and R Q3 Each occurrence is independently of hydrogen, halogen, -CN, -NO2, -OH, -NH2, C 1-6 Alkyl, C 1-6 Alkoxy, C 1-6 Alkylamino, C 2-6 Alkenil, C 2-6 Alkinyl, C 3-6Carbocyclyl, 3-6 membered heterocyclyl, C6 aryl, or 5-6 membered heteroaryl, and alkyl, alkoxy, alkylamino, alkenyl, alkynyl, carbocykrill, heterocyclyl, aryl, or heteroaryl is one or more R u It may be replaced with .

[0229] In a particular embodiment, R Q2 and R Q3 Each occurrence is independently of hydrogen, halogen, -CN, -NO2, -OH, -NH2, C 1-6 Alkyl, C 1-6 Alkoxy, C 1-6 Alkylamino, C 2-6 Alkenil, C 2-6 Alkinyl, C 3-6 Carbocyclyl, or 3-6 membered heterocyclyl, wherein alkyl, alkoxy, alkylamino, alkenyl, alkynyl, carbocyclyl, or heterocyclyl is one or more R u It may be replaced with .

[0230] In a particular embodiment, R Q2 and R Q3 Each occurrence is independently of hydrogen, halogen, -CN, -NO2, -OH, -NH2, C 1-6 Alkyl, C 1-6 Alkoxy, C 1-6 Alkylamino, C 3-6 Carbocyclyl, or 3-6 membered heterocyclyl, wherein alkyl, alkoxy, alkylamino, carbocyclyl, or heterocyclyl is one or more R u It may be replaced with .

[0231] In a specific method of operation, each R Q2 It is hydrogen.

[0232] In certain embodiments, two R Q2 or two R's Q3 Together with the carbon atoms to which they are bonded, C 3-6Carbocyclyls (e.g., cyclopropyl (C3), cyclopropenyl (C3), cyclobutyl (C4), cyclobutenyl (C4), cyclopentyl (C5), cyclopentenyl (C5), cyclohexyl (C6), cyclohexenyl (C6), or cyclohexadienyl (C6)) or 3-6 membered heterocyclyls (e.g., heterocyclyls containing one 3-6 membered ring and 1-3 heteroatoms selected from N, O, and S), wherein the carbocyclic or heterocyclic ring contains one or more R u It may be replaced with .

[0233] In a particular embodiment, S 1 CR S1 Or it is N.

[0234] In a particular embodiment, S 2 teeth, TIFF2026521988000202.tif8128,CR S2 , or N.

[0235] In a particular embodiment, S 3 teeth, TIFF2026521988000203.tif8128,CR S3 , or N.

[0236] In a particular embodiment, S 4 teeth, TIFF2026521988000204.tif8128,CR S4 , or N.

[0237] In a particular embodiment, R S1 , R S2 , R S3 , and R S4 These are independently oxo, hydrogen, halogen (e.g., -F, -Cl, -Br, or -I), -CN, -NO2, -OH, -NH2, C 1-6Alkyl (e.g., methyl (C1), ethyl (C2), n-propyl (C3), i-propyl (C3), n-butyl (C4), i-butyl (C4), s-butyl (C4), t-butyl (C4), pentyl (C5), or hexyl (C6)), C 1-6 Alkoxy (e.g., methoxy (C1), ethoxy (C2), propoxy (C3), i-propoxy (C3), n-butoxy (C4), i-butoxy (C4), s-butoxy (C4), t-butoxy (C4), pentoxy (C5), or hexoxy (C6)), C 1-6 Alkylaminos (e.g., dimethylamino, diethylamino, di-n-propylamino, di-i-propylamino, di-n-butylamino, di-i-butylamino, di-s-butylamino, di-t-butylamino, dipentylamino, dihexylamino, methylethylamino, methyl-n-propylamino, methyl-i-propylamino, methyl-n-butylamino, methyl-i-butylamino, methyl-s-butylamino, methyl-t-butylamino, methylpentylamino, methylhexylamino, ethyl-n-propylamino, ethyl-i-propylamino, ethyl-n-butylamino) (No, ethyl-s-butylamino, ethyl-i-butylamino, ethyl-t-butylamino, ethylpentylamino, ethylhexylamino, propyl-n-butylamino, propyl-i-butylamino, propyl-s-butylamino, propyl-t-butylamino, propylpentyrylamino, propylhexylamino, n-butylpentylamino, i-butylpentylamino, s-butylpentylamino, t-butylpentylamino, n-butylhexylamino, i-butylhexylamino, s-butylhexylamino, t-butylpentylamino, n-butylhexylamino, i-butylhexylamino, s-butylhexylamino, t-butylhexylamino, or pentylhexylamino), C 2-6 Alkenyls (e.g., etenyl (C2), 1-propenyl (C3), 2-propenyl (C3), 1-butenyl (C4), 2-butenyl (C4), butadienyl (C4), pentenyl (C5), pentadienyl (C5), or hexenyl (C6)), C 2-6Alkynnyl (e.g., ethinyl (C2), 1-propynyl (C3), 2-propynyl (C3), 1-butynyl (C4), 2-butynyl (C4), pentynyl (C5), or hexynyl (C6)), C 3-12 Carbocyclyl (e.g., cyclopropyl (C3), cyclopropenyl (C3), cyclobutyl (C4), cyclobutenyl (C4), cyclopentyl (C5), cyclopentenyl (C5), cyclohexyl (C6), cyclohexenyl (C6), cyclohexadienyl (C6), cycloheptyl (C7), cycloheptenyl (C7), cycloheptadienyl (C7), cycloheptatrienyl (C7), cyclooctyl (C8), cyclooctenyl (C8), bicyclo[2.2.1]heptanyl (C7), bicyclo[2.2.2]octanyl (C8), cyclononyl (C9), cyclononenyl (C9), cyclodecyl (C) 10 ), cyclodecenyl (C 10 ), octahydro-1H-indenyl (C9), decahydronaphthalenyl (C9) 10 ), or spiro[4.5]decanil(C 10 )), 3-12 membered heterocyclines (e.g., heterocyclines containing one or two 3-8 membered rings and 1-5 heteroatoms selected from N, O, and S), C 6-10 Aryl (e.g., phenyl or naphthyl), 5-10 membered heteroaryl (e.g., heteroaryl containing one or two 5 or 6 membered rings and 1-5 heteroatoms selected from N, O, and S), -SR b -S(=O)R a -S(=O)2R a -S(=O)2OR b -S(=O)2NR c R d , -NR c S(=O)2R a , -NR c S(=O)R a , -NR c S(=O)2OR b , -NR c S(=O)2NR c R d , -NR b C(=O)NR cR d , -NR b C(=O)R a , -NR b C(=O)OR b -OS(=O)2R a -OS(=O)2OR b -OS(=O)2NR c R d -OC(=O)R a , -OC(=O)OR b -OC(=O)NR c R d -C(=O)R a , -C(=O)OR b , or -C(=O)NR c R d Alkyl, alkoxy, alkylamino, alkenyl, alkynyl, carbocykyl, heterocyclyl, aryl, or heteroaryl is one or more R u It may be replaced with .

[0238] In a particular embodiment, R S1 , R S2 , R S3 , and R S4 These are independently oxo, hydrogen, halogen, -CN, -NO2, -OH, -NH2, C 1-6 Alkyl, C 1-6 Alkoxy, C 1-6 Alkylamino, C 2-6 Alkenil, C 2-6 Alkinyl, C 3-12 Carbocyclyl, 3-12 member heterocyclyl, C 6-10 The aryl or 5-10 membered heteroaryl is an alkyl, alkoxy, alkylamino, alkenyl, alkynyl, carbocykrill, heterocyclyl, aryl, or heteroaryl, which has one or more R u It may be replaced with .

[0239] In a particular embodiment, R S1 , R S2 , R S3 , and R S4 These are independently oxo, hydrogen, halogen, -CN, -NO2, -OH, -NH2, C1-6 Alkyl, C 1-6 Alkoxy, C 1-6 Alkylamino, C 2-6 Alkenil, C 2-6 Alkinyl, C 3-6 Carbocyclyl, 3-6 membered heterocyclyl, C6 aryl, or 5-6 membered heteroaryl, and alkyl, alkoxy, alkylamino, alkenyl, alkynyl, carbocykrill, heterocyclyl, aryl, or heteroaryl is one or more R u It may be replaced with .

[0240] In a particular embodiment, R S1 , R S2 , R S3 , and R S4 These are independently oxo, hydrogen, halogen, -CN, -NO2, -OH, -NH2, C 1-6 Alkyl, C 1-6 Alkoxy, C 1-6 Alkylamino, C 2-6 Alkenil, C 2-6 Alkinyl, C 3-6 Carbocyclyl, or 3-6 membered heterocyclyl, wherein alkyl, alkoxy, alkylamino, alkenyl, alkynyl, carbocyclyl, or heterocyclyl is one or more R u It may be replaced with .

[0241] In a particular embodiment, R S1 , R S2 , R S3 , and R S4 These are independently oxo, hydrogen, halogen, -CN, -NO2, -OH, -NH2, C 1-6 Alkyl, C 1-6 Alkoxy, C 1-6 Alkylamino, C 3-6 Carbocyclyl, or 3-6 membered heterocyclyl, wherein alkyl, alkoxy, alkylamino, carbocyclyl, or heterocyclyl is one or more R u It may be replaced with .

[0242] In a particular embodiment, RS1 and R S3 Both are hydrogen.

[0243] In a particular embodiment, R S2 is hydrogen, C 1-6 It is alkyl or C1-6 alkoxy.

[0244] In a particular embodiment, R S2 C 1-6 Alkyl, C 1-6 Alkoxy, or C 3-12 It is a carbocyclyl, and the alkyl, alkoxy, or carbocyclyl is one or more R u It may be replaced with .

[0245] In a particular embodiment, R S2 C 1-6 Alkyl, C 1-6 Alkoxy, or C 3-12 Carbocyclyl is an alkyl, alkoxy, or carbocyclyl, which is one or more oxo, halogen, and C 1-6 It may be substituted with alkyl.

[0246] In a particular embodiment, R S4 is hydrogen or C 1-6 It is alkyl.

[0247] In certain embodiments, T is the formula I-3-vi-a-1 or I-3-vi-a-2. TIFF2026521988000205.tif18128

[0248] In certain embodiments, T is an expression of formula I-3-vi-a-1-a, I-3-vi-a-1-b, I-3-vi-a-2-a, or I-3-vi-a-2-b. TIFF2026521988000206.tif38149

[0249] In certain embodiments, T is Selected from the group consisting of TIFF2026521988000207.tif124132.

[0250] In certain embodiments, T is the formula I-3-ii, I-3-iv, or I-3-vi.

[0251] In a particular embodiment, L is the formula of formula I-2'', TIFF2026521988000208.tif10128In formula, TIFF2026521988000209.tif5128 shows adhesion to C, Cy 1 teeth, The filename is TIFF2026521988000210.tif20128, and in the formula, TIFF2026521988000211.tif6128 shows adhesion to T, T 1 CR T1 or N, V 1 CR V1 or N, V 2 CR V2 or N, R T1 , R V1 , and R V2 These are independently hydrogen, halogen, -CN, -NO2, -OH, -NH2, C 1-6 Alkyl, C 1-6 Alkoxy, C 1-6 Alkylamino, C 3-4 Carbocyclyl, or 3-4 membered heterocyclyl, Each R T These are, independently, halogen, -CN, -NO2, -OH, -NH2, C 1-6 Alkyl, C 1-6 Alkoxy, C 1-6 Alkylamino, C 3-4 Carbocyclyl, or 3-4 membered heterocyclyl, t is an integer selected from 0 to 6, as long as the valence allows. or Cy1 teeth, It is TIFF2026521988000212.tif23128, and in the formula, If TIFF2026521988000213.tif1128 has a double bond, Y 1 is C, If TIFF2026521988000214.tif1128 is a single join, Y 1 is N or CR Y1 And, TIFF2026521988000215.tif6128 shows adhesion to T, R Y1 These are hydrogen, halogen, -CN, -NO2, -OH, -NH2, C 1-6 Alkyl, C 1-6 Alkoxy, C 1-6 Alkylamino, C 3-4 Carbocyclyl, or 3-4 membered heterocyclyl, Y 2 C(R Y2 )2, O, or N(R Y2’ ) and Each R Y2 These are independently hydrogen, halogen, -CN, -NO2, -OH, -NH2, C 1-6 Alkyl, C 1-6 Alkoxy, C 1-6 Alkylamino, C 3-4 Carbocyclyl, or 3-4 membered heterocyclyl, R Y2’ is hydrogen, C 1-6 Alkyl, C 3-4 Carbocyclyl, 3-4 member heterocyclyl, -S(=O)2R a -S(=O)2OR b -S(=O)2NR c R d -C(=O)R a , -C(=O)OR b , or -C(=O)NR c R d And, Z 1 CR Z1 or N, Z 2CR Z2 or N, R Z1 and R Z2 These are independently hydrogen, halogen, -CN, -NO2, -OH, -NH2, C 1-6 Alkyl, C 1-6 Haloalkyl, C 1-6 Alkoxy, C 1-6 Alkylamino, C 3-4 Carbocyclyl, or 3-4 membered heterocyclyl, Each R Z These are independently oxo, halogen, -CN, -NO2, -OH, -NH2, C 1-6 Alkyl, C 1-6 Alkoxy, C 1-6 Alkylamino, C 3-4 Carbocyclyl, or 3-4 membered heterocyclyl, z is an integer selected from 0 to 6, as long as the valence allows. Here, R Z It may exist in either ring Y or ring Z. Cy 2 These are C6 arylenes or 5-6 member heteroarylenes, and each arylene or heteroarylene is composed of one or more R u It may also be replaced with L 2 CH2 or CH(C 1-3 It is alkyl, L 3 These are E-ethenylene, ethynylene, C6 arylene, or 5-6 member heteroarylene, and E-ethenylene, arylene, or heteroarylene contains one or more R u It may be replaced with .

[0252] In a particular embodiment, L is the formula of formula I-2'', TIFF2026521988000216.tif10128 formula, TIFF2026521988000217.tif5128 shows adhesion to C, Cy 1 teeth, The filename is TIFF2026521988000218.tif20128, and in the formula, TIFF2026521988000219.tif6128 shows adhesion to T, T 1 CR T1 And, V 1 N is, V 2 CR V2 And, R T1 and R V2 It is independently hydrogen, t is 0. or Cy 1 teeth, The filename is TIFF2026521988000220.tif23128, and in the formula, TIFF2026521988000221.tif1128 is a single bond, Y 1 N is, TIFF2026521988000222.tif6128 shows adhesion to T, Y 2 O is, Z 1 CR Z1 or N, Z 2 CR Z2 And, R Z1 and R Z2 These are independently hydrogen or halogen, z is 0, Cy 2 It is a 5-6 member heteroarylene, L 2 It is CH2, L 3 It is ethynylene.

[0253] In a particular embodiment, L is the formula of formula I-2', TIFF2026521988000223.tif10128 formula, TIFF2026521988000224.tif5128 shows adhesion to C, Cy 1 teeth, The filename is TIFF2026521988000225.tif20128, and in the formula, TIFF2026521988000226.tif6128 shows adhesion to T, T 1 CR T1 or N, V 1 CR V1 or N, V 2 CR V2 or N, R T1 , R V1 , and R V2 These are independently hydrogen, halogen, -CN, -NO2, -OH, -NH2, C 1-6 Alkyl, C 1-6 Alkoxy, C 1-6 Alkylamino, C 3-4 Carbocyclyl, or 3-4 membered heterocyclyl, wherein alkyl, alkoxy, alkylamino, carbocyclyl, or heterocyclyl is one or more R u It may also be replaced with Each R T These are, independently, halogen, -CN, -NO2, -OH, -NH2, C 1-6 Alkyl, C 1-6 Alkoxy, C 1-6 Alkylamino, C 3-4 Carbocyclyl, or 3-4 membered heterocyclyl, wherein alkyl, alkoxy, alkylamino, carbocyclyl, or heterocyclyl is one or more R u It may also be replaced with t is an integer selected from 0 to 6, as long as the valence allows, or Cy 1 teeth, The filename is TIFF2026521988000227.tif19128, and in the formula, Y 1 is N or CR Y1 And, TIFF2026521988000228.tif6128 shows adhesion to T, R Y1 These are hydrogen, halogen, -CN, -NO2, -OH, -NH2, C 1-6 Alkyl, C 1-6 Alkoxy, C 1-6 Alkylamino, C 3-4 Carbocyclyl, or 3-4 membered heterocyclyl, wherein alkyl, alkoxy, alkylamino, carbocyclyl, or heterocyclyl is one or more R u It may also be replaced with Y 2 C(R Y2 )2, O, or N(R Y2’ ) and Each R Y2 These are independently hydrogen, halogen, -CN, -NO2, -OH, -NH2, C 1-6 Alkyl, C 1-6 Alkoxy, C 1-6 Alkylamino, C 3-4 Carbocyclyl, or 3-4 membered heterocyclyl, wherein alkyl, alkoxy, alkylamino, carbocyclyl, or heterocyclyl is one or more R u It may also be replaced with R Y2’ is hydrogen, C 1-6 Alkyl, C 3-4 Carbocyclyl, 3-4 member heterocyclyl, -S(=O)2R a -S(=O)2OR b -S(=O)2NR c R d -C(=O)R a , -C(=O)OR b , or -C(=O)NR c R d And alkyl, carbocykryl, or heterocyclyl is one or more R u It may also be replaced with Z 1 CR Z1 or N, R Z1 These are hydrogen, halogen, -CN, -NO2, -OH, -NH2, C1-6 Alkyl, C 1-6 Alkoxy, C 1-6 Alkylamino, C 3-4 Carbocyclyl, or 3-4 membered heterocyclyl, wherein alkyl, alkoxy, alkylamino, carbocyclyl, or heterocyclyl is one or more R u It may also be replaced with Each R Z These are independently oxo, halogen, -CN, -NO2, -OH, -NH2, C 1-6 Alkyl, C 1-6 Alkoxy, C 1-6 Alkylamino, C 3-4 Carbocyclyl, or 3-4 membered heterocyclyl, wherein alkyl, alkoxy, alkylamino, carbocyclyl, or heterocyclyl is one or more R u It may also be replaced with z is an integer selected from 0 to 6, as long as the valence allows. Here, R Z It may exist in either ring Y or ring Z. Cy 2 These are 5-6 member heteroarylenes, and heteroarylenes contain one or more R u It may also be replaced with L 2 CH2 or CH(C 1-3 It is alkyl, L 3 These are E-ethenylene, ethynylene, C6 arylene, or 5-6 member heteroarylene, and E-ethenylene, arylene, or heteroarylene contains one or more R u It may be replaced with .

[0254] In a particular embodiment, L is the formula in formula I-2, TIFF2026521988000229.tif10128In formula, TIFF2026521988000230.tif5128 shows adhesion to C, Cy 1 teeth, The filename is TIFF2026521988000231.tif20128, and in the formula, TIFF2026521988000232.tif6128 shows adhesion to T, T 1 CR T1 or N, V 1 CR V1 or N, V 2 CR V2 or N, R T1 , R V1 , and R V2 These are independently hydrogen, halogen, -CN, -NO2, -OH, -NH2, C 1-6 Alkyl, C 1-6 Alkoxy, C 1-6 Alkylamino, C 3-4 Carbocyclyl, or 3-4 membered heterocyclyl, wherein alkyl, alkoxy, alkylamino, carbocyclyl, or heterocyclyl is one or more R u It may also be replaced with Each R T These are, independently, halogen, -CN, -NO2, -OH, -NH2, C 1-6 Alkyl, C 1-6 Alkoxy, C 1-6 Alkylamino, C 3-4 Carbocyclyl, or 3-4 membered heterocyclyl, wherein alkyl, alkoxy, alkylamino, carbocyclyl, or heterocyclyl is one or more R u It may also be replaced with t is an integer selected from 0 to 6, as long as the valence allows, or Cy 1 teeth, TIFF2026521988000233.tif19128, and in the formula, Y 1 is N or CR Y1 And, TIFF2026521988000234.tif6128 shows adhesion to T, R Y1These are hydrogen, halogen, -CN, -NO2, -OH, -NH2, C 1-6 Alkyl, C 1-6 Alkoxy, C 1-6 Alkylamino, C 3-4 Carbocyclyl, or 3-4 membered heterocyclyl, wherein alkyl, alkoxy, alkylamino, carbocyclyl, or heterocyclyl is one or more R u It may also be replaced with Y 2 C(R Y2 )2, O, or N(R Y2’ ) and Each R Y2 These are independently hydrogen, halogen, -CN, -NO2, -OH, -NH2, C 1-6 Alkyl, C 1-6 Alkoxy, C 1-6 Alkylamino, C 3-4 Carbocyclyl, or 3-4 membered heterocyclyl, wherein alkyl, alkoxy, alkylamino, carbocyclyl, or heterocyclyl is one or more R u It may also be replaced with R Y2’ is hydrogen, C 1-6 Alkyl, C 3-4 Carbocyclyl, 3-4 member heterocyclyl, -S(=O)2R a -S(=O)2OR b -S(=O)2NR c R d -C(=O)R a , -C(=O)OR b , or -C(=O)NR c R d And alkyl, carbocykryl, or heterocyclyl is one or more R u It may also be replaced with Z 1 CR Z1 or N, R Z1 These are hydrogen, halogen, -CN, -NO2, -OH, -NH2, C 1-6 Alkyl, C 1-6 Alkoxy, C 1-6 Alkylamino, C 3-4Carbocyclyl, or 3-4 membered heterocyclyl, wherein alkyl, alkoxy, alkylamino, carbocyclyl, or heterocyclyl is one or more R u It may also be replaced with Each R Z These are independently oxo, halogen, -CN, -NO2, -OH, -NH2, C 1-6 Alkyl, C 1-6 Alkoxy, C 1-6 Alkylamino, C 3-4 Carbocyclyl, or 3-4 membered heterocyclyl, wherein alkyl, alkoxy, alkylamino, carbocyclyl, or heterocyclyl is one or more R u It may also be replaced with z is an integer selected from 0 to 6, as long as the valence allows. Here, R Z It may exist in either ring Y or ring Z. Cy 2 It is a 5-6 member heteroarylene, L 3 These are E-ethenylene, ethynylene, C6 arylene, or 5-6 membered heteroarylene.

[0255] In a particular embodiment, L is the formula of formula I-2-a''. TIFF2026521988000235.tif20128

[0256] In a particular embodiment, Cy 1 teeth, The filename is TIFF2026521988000236.tif20128, and in the formula, TIFF2026521988000237.tif6128 shows adhesion to T, T 1 CR T1 And, V 1 N is, V 2 CR V2 And, R T1 and R V2These are independently hydrogen, halogen, -CN, -NO2, -OH, -NH2, C 1-6 Alkyl, C 1-6 Alkoxy, C 1-6 Alkylamino, C 3-4 Carbocyclyl, or 3-4 membered heterocyclyl, Each R T These are, independently, halogen, -CN, -NO2, -OH, -NH2, C 1-6 Alkyl, C 1-6 Alkoxy, C 1-6 Alkylamino, C 3-4 Carbocyclyl, or 3-4 membered heterocyclyl, t is an integer selected from 0 to 6, as long as the valence allows.

[0257] In a particular embodiment, Cy 1 The following applies: TIFF2026521988000238.tif17128

[0258] In a particular embodiment, T 1 CR T1 Or N. In a particular embodiment, T 1 CR T1 In a particular embodiment, T 1 It is N.

[0259] In a particular embodiment, V 1 CR V1 Or N. In a particular embodiment, V 1 CR V1 In a particular embodiment, V 2 It is N.

[0260] In a particular embodiment, V 2 CR V2 Or N. In a particular embodiment, V 2 CR V2 In a particular embodiment, V 2 It is N.

[0261] In a particular embodiment, R T1, R V1 , and R V2 These are independently hydrogen, halogens (e.g., -F, -Cl, -Br, or -I), -CN, -NO2, -OH, -NH2, C 1-6 Alkyl (e.g., methyl (C1), ethyl (C2), n-propyl (C3), i-propyl (C3), n-butyl (C4), i-butyl (C4), s-butyl (C4), t-butyl (C4), pentyl (C5), or hexyl (C6)), C 1-6 Alkoxy (e.g., methoxy (C1), ethoxy (C2), propoxy (C3), i-propoxy (C3), n-butoxy (C4), i-butoxy (C4), s-butoxy (C4), t-butoxy (C4), pentoxy (C5), or hexoxy (C6)), C 1-6 Alkylaminos (e.g., dimethylamino, diethylamino, di-n-propylamino, di-i-propylamino, di-n-butylamino, di-i-butylamino, di-s-butylamino, di-t-butylamino, dipentylamino, dihexylamino, methylethylamino, methyl-n-propylamino, methyl-i-propylamino, methyl-n-butylamino, methyl-i-butylamino, methyl-s-butylamino, methyl-t-butylamino, methylpentylamino, methylhexylamino, ethyl-n-propylamino, ethyl-i-propylamino, ethyl-n-butylamino) (No, ethyl-s-butylamino, ethyl-i-butylamino, ethyl-t-butylamino, ethylpentylamino, ethylhexylamino, propyl-n-butylamino, propyl-i-butylamino, propyl-s-butylamino, propyl-t-butylamino, propylpentyrylamino, propylhexylamino, n-butylpentylamino, i-butylpentylamino, s-butylpentylamino, t-butylpentylamino, n-butylhexylamino, i-butylhexylamino, s-butylhexylamino, t-butylpentylamino, n-butylhexylamino, i-butylhexylamino, s-butylhexylamino, t-butylhexylamino, or pentylhexylamino), C 3-4Carbocyclyl (e.g., cyclopropyl (C3), cyclopropenyl (C3), cyclobutyl (C4), or cyclobutenyl (C4)) or 3-4 membered heterocyclyl (e.g., a heterocyclyl containing one 3-4 membered ring and one heteroatom selected from N, O, and S), wherein alkyl, alkoxy, alkylamino, carbocyclyl, or heterocyclyl contains one or more R u It may be replaced with .

[0262] In a particular embodiment, R T1 , R V1 , and R V2 These are independently hydrogen, halogen, -CN, -NO2, -OH, -NH2, C 1-6 Alkyl, C 1-6 Alkoxy, C 1-6 Alkylamino, C 2-6 Alkenil, C 2-6 Alkinyl, C 3-6 Carbocyclyl, 3-6 membered heterocyclyl, C6 aryl, or 5-6 membered heteroaryl, and alkyl, alkoxy, alkylamino, alkenyl, alkynyl, carbocykrill, heterocyclyl, aryl, or heteroaryl is one or more R u It may be replaced with .

[0263] In a particular embodiment, R T1 , R V1 , and R V2 These are independently hydrogen, halogen, -CN, -NO2, -OH, -NH2, C 1-6 Alkyl, C 1-6 Alkoxy, C 1-6 Alkylamino, C 2-6 Alkenil, C 2-6 Alkinyl, C 3-6 Carbocyclyl, or 3-6 membered heterocyclyl, wherein alkyl, alkoxy, alkylamino, alkenyl, alkynyl, carbocyclyl, or heterocyclyl is one or more R u It may be replaced with .

[0264] In a particular embodiment, R T1, R V1 , and R V2 These are independently hydrogen, halogen, -CN, -NO2, -OH, -NH2, C 1-6 Alkyl, C 1-6 Alkoxy, C 1-6 Alkylamino, C 3-6 Carbocyclyl, or 3-6 membered heterocyclyl, wherein alkyl, alkoxy, alkylamino, carbocyclyl, or heterocyclyl is one or more R u It may be replaced with .

[0265] In a particular embodiment, R T1 and R V2 Both are hydrogen.

[0266] In a specific method of operation, each R T These are independently halogens (e.g., -F, -Cl, -Br, or -I), -CN, -NO2, -OH, -NH2, C 1-6 Alkyl (e.g., methyl (C1), ethyl (C2), n-propyl (C3), i-propyl (C3), n-butyl (C4), i-butyl (C4), s-butyl (C4), t-butyl (C4), pentyl (C5), or hexyl (C6)), C 1-6 Alkoxy (e.g., methoxy (C1), ethoxy (C2), propoxy (C3), i-propoxy (C3), n-butoxy (C4), i-butoxy (C4), s-butoxy (C4), t-butoxy (C4), pentoxy (C5), or hexoxy (C6)), C 1-6Alkylaminos (e.g., dimethylamino, diethylamino, di-n-propylamino, di-i-propylamino, di-n-butylamino, di-i-butylamino, di-s-butylamino, di-t-butylamino, dipentylamino, dihexylamino, methylethylamino, methyl-n-propylamino, methyl-i-propylamino, methyl-n-butylamino, methyl-i-butylamino, methyl-s-butylamino, methyl-t-butylamino, methylpentylamino, methylhexylamino, ethyl-n-propylamino, ethyl-i-propylamino, ethyl-n-butylamino) (No, ethyl-s-butylamino, ethyl-i-butylamino, ethyl-t-butylamino, ethylpentylamino, ethylhexylamino, propyl-n-butylamino, propyl-i-butylamino, propyl-s-butylamino, propyl-t-butylamino, propylpentyrylamino, propylhexylamino, n-butylpentylamino, i-butylpentylamino, s-butylpentylamino, t-butylpentylamino, n-butylhexylamino, i-butylhexylamino, s-butylhexylamino, t-butylpentylamino, n-butylhexylamino, i-butylhexylamino, s-butylhexylamino, t-butylhexylamino, or pentylhexylamino), C 3-4 Carbocyclyl (e.g., cyclopropyl (C3), cyclopropenyl (C3), cyclobutyl (C4), or cyclobutenyl (C4)) or 3-4 membered heterocyclyl (e.g., a heterocyclyl containing one 3-4 membered ring and one heteroatom selected from N, O, and S), wherein alkyl, alkoxy, alkylamino, carbocyclyl, or heterocyclyl contains one or more R u It may be replaced with .

[0267] In a specific method of operation, each R T C 1-6 It is alkyl. In certain embodiments, at least one R T C 1-6 It is alkyl.

[0268] In certain embodiments, t is 0. In certain embodiments, t is 1. In certain embodiments, t is 2. In certain embodiments, t is 3. In certain embodiments, t is 4. In certain embodiments, t is 5. In certain embodiments, t is 6.

[0269] In a particular embodiment, Cy 1 teeth, TIFF2026521988000239.tif19128, and in the formula, Y 1 is N or CR Y1 And, TIFF2026521988000240.tif6128 shows adhesion to T, R Y1 These are hydrogen, halogen, -CN, -NO2, -OH, -NH2, C 1-6 Alkyl, C 1-6 Alkoxy, C 1-6 Alkylamino, C 3-4 Carbocyclyl, or 3-4 membered heterocyclyl, wherein alkyl, alkoxy, alkylamino, carbocyclyl, or heterocyclyl is one or more R u It may also be replaced with Y 2 C(R Y2 )2, O, or N(R Y2’ ) and Each R Y2 These are independently hydrogen, halogen, -CN, -NO2, -OH, -NH2, C 1-6 Alkyl, C 1-6 Alkoxy, C 1-6 Alkylamino, C 3-4 Carbocyclyl, or 3-4 membered heterocyclyl, wherein alkyl, alkoxy, alkylamino, carbocyclyl, or heterocyclyl is one or more R u It may also be replaced with R Y2’ is hydrogen, C 1-6 Alkyl, C 3-4 Carbocyclyl, 3-4 member heterocyclyl, -S(=O)2R a -S(=O)2ORb -S(=O)2NR c R d -C(=O)R a , -C(=O)OR b , or -C(=O)NR c R d And alkyl, carbocykryl, or heterocyclyl is one or more R u It may also be replaced with Z 1 CR Z1 or N, R Z1 These are hydrogen, halogen, -CN, -NO2, -OH, -NH2, C 1-6 Alkyl, C 1-6 Alkoxy, C 1-6 Alkylamino, C 3-4 Carbocyclyl, 3-4 membered heterocyclyl, alkyl, alkoxy, alkylamino, carbocyclyl, or heterocyclyl, one or more R u It may also be replaced with Each R Z These are independently oxo, halogen, -CN, -NO2, -OH, -NH2, C 1-6 Alkyl, C 1-6 Alkoxy, C 1-6 Alkylamino, C 3-4 Carbocyclyl, or 3-4 membered heterocyclyl, wherein alkyl, alkoxy, alkylamino, carbocyclyl, or heterocyclyl is one or more R u It may also be replaced with z is an integer selected from 0 to 6, as long as the valence allows. Here, R Z It may exist in either ring Y or ring Z.

[0270] In a particular embodiment, Cy 1 teeth, TIFF2026521988000241.tif23128, and in the formula, If TIFF2026521988000242.tif1128 has a double bond, Y 1 is C, If TIFF2026521988000243.tif1128 is a single join, Y 1 is N or CR Y1 And, TIFF2026521988000244.tif6128 shows adhesion to T, R Y1 These are hydrogen, halogen, -CN, -NO2, -OH, -NH2, C 1-6 Alkyl, C 1-6 Alkoxy, C 1-6 Alkylamino, C 3-4 Carbocyclyl, or 3-4 membered heterocyclyl, Y 2 C(R Y2 )2, O, or N(R Y2’ ) and Each R Y2 These are independently hydrogen, halogen, -CN, -NO2, -OH, -NH2, C 1-6 Alkyl, C 1-6 Alkoxy, C 1-6 Alkylamino, C 3-4 Carbocyclyl, or 3-4 membered heterocyclyl, R Y2’ is hydrogen, C 1-6 Alkyl, C 3-4 Carbocyclyl, 3-4 member heterocyclyl, -S(=O)2R a -S(=O)2OR b -S(=O)2NR c R d -C(=O)R a , -C(=O)OR b , or -C(=O)NR c R d And, Z 1 CR Z1 or N, Z 2 CR Z2 or N, R Z1 and RZ2 These are independently hydrogen, halogen, -CN, -NO2, -OH, -NH2, C 1-6 Alkyl, C 1-6 Haloalkyl, C1-6 Alkoxy, C 1-6 Alkylamino, C 3-4 Carbocyclyl, or 3-4 membered heterocyclyl, Each R Z These are independently oxo, halogen, -CN, -NO2, -OH, -NH2, C 1-6 Alkyl, C 1-6 Alkoxy, C 1-6 Alkylamino, C 3-4 Carbocyclyl, or 3-4 membered heterocyclyl, z is an integer selected from 0 to 6, as long as the valence allows. Here, R Z It may exist in either ring Y or ring Z.

[0271] In a particular embodiment, Cy 1 teeth, The file is TIFF2026521988000245.tif23128, and in the formula, R Z1 teeth 、 C substituted with one or more halogens 1-6 It is alkyl.

[0272] In a particular embodiment, Cy 1 teeth, The filename is TIFF2026521988000246.tif81142.

[0273] In a particular embodiment, Cy 1 teeth, The filename is TIFF2026521988000247.tif110144.

[0274] In a particular embodiment, Y 1 is N or CR Y1 In a particular embodiment, Y 1 In a particular embodiment, Y 1 CR Y1 That is the case.

[0275] In a particular embodiment, Y 1 It is C.

[0276] In a particular embodiment, TIFF2026521988000248.tif1128 is a single bond. In certain embodiments, TIFF2026521988000249.tif1128 has a double bond.

[0277] In a particular embodiment, R Y1 These include hydrogen, halogens (e.g., -F, -Cl, -Br, or -I), -CN, -NO2, -OH, -NH2, and C. 1-6 Alkyl (e.g., methyl (C1), ethyl (C2), n-propyl (C3), i-propyl (C3), n-butyl (C4), i-butyl (C4), s-butyl (C4), t-butyl (C4), pentyl (C5), or hexyl (C6)), C 1-6 Alkoxy (e.g., methoxy (C1), ethoxy (C2), propoxy (C3), i-propoxy (C3), n-butoxy (C4), i-butoxy (C4), s-butoxy (C4), t-butoxy (C4), pentoxy (C5), or hexoxy (C6)), C 1-6Alkylaminos (e.g., dimethylamino, diethylamino, di-n-propylamino, di-i-propylamino, di-n-butylamino, di-i-butylamino, di-s-butylamino, di-t-butylamino, dipentylamino, dihexylamino, methylethylamino, methyl-n-propylamino, methyl-i-propylamino, methyl-n-butylamino, methyl-i-butylamino, methyl-s-butylamino, methyl-t-butylamino, methylpentylamino, methylhexylamino, ethyl-n-propylamino, ethyl-i-propylamino, ethyl-n-butylamino) (No, ethyl-s-butylamino, ethyl-i-butylamino, ethyl-t-butylamino, ethylpentylamino, ethylhexylamino, propyl-n-butylamino, propyl-i-butylamino, propyl-s-butylamino, propyl-t-butylamino, propylpentyrylamino, propylhexylamino, n-butylpentylamino, i-butylpentylamino, s-butylpentylamino, t-butylpentylamino, n-butylhexylamino, i-butylhexylamino, s-butylhexylamino, t-butylpentylamino, n-butylhexylamino, i-butylhexylamino, s-butylhexylamino, t-butylhexylamino, or pentylhexylamino), C 3-4 Carbocyclyl (e.g., cyclopropyl (C3), cyclopropenyl (C3), cyclobutyl (C4), or cyclobutenyl (C4)) or 3-4 membered heterocyclyl (e.g., a heterocyclyl containing one 3-4 membered ring and one heteroatom selected from N, O, and S), wherein alkyl, alkoxy, alkylamino, carbocyclyl, or heterocyclyl contains one or more R u It may be replaced with .

[0278] In a particular embodiment, Y 2 C(R Y2 )2, O, or N(R Y2’ )

[0279] In a particular embodiment, Y 2 It is CH2, O, or NMe.

[0280] In a specific method of operation, each R Y2These are independently hydrogen, halogens (e.g., -F, -Cl, -Br, or -I), -CN, -NO2, -OH, -NH2, C 1-6 Alkyl (e.g., methyl (C1), ethyl (C2), n-propyl (C3), i-propyl (C3), n-butyl (C4), i-butyl (C4), s-butyl (C4), t-butyl (C4), pentyl (C5), or hexyl (C6)), C 1-6 Alkoxy (e.g., methoxy (C1), ethoxy (C2), propoxy (C3), i-propoxy (C3), n-butoxy (C4), i-butoxy (C4), s-butoxy (C4), t-butoxy (C4), pentoxy (C5), or hexoxy (C6)), C 1-6 Alkylaminos (e.g., dimethylamino, diethylamino, di-n-propylamino, di-i-propylamino, di-n-butylamino, di-i-butylamino, di-s-butylamino, di-t-butylamino, dipentylamino, dihexylamino, methylethylamino, methyl-n-propylamino, methyl-i-propylamino, methyl-n-butylamino, methyl-i-butylamino, methyl-s-butylamino, methyl-t-butylamino, methylpentylamino, methylhexylamino, ethyl-n-propylamino, ethyl-i-propylamino, ethyl-n-butylamino) (No, ethyl-s-butylamino, ethyl-i-butylamino, ethyl-t-butylamino, ethylpentylamino, ethylhexylamino, propyl-n-butylamino, propyl-i-butylamino, propyl-s-butylamino, propyl-t-butylamino, propylpentyrylamino, propylhexylamino, n-butylpentylamino, i-butylpentylamino, s-butylpentylamino, t-butylpentylamino, n-butylhexylamino, i-butylhexylamino, s-butylhexylamino, t-butylpentylamino, n-butylhexylamino, i-butylhexylamino, s-butylhexylamino, t-butylhexylamino, or pentylhexylamino), C 3-4Carbocyclyl (e.g., cyclopropyl (C3), cyclopropenyl (C3), cyclobutyl (C4), or cyclobutenyl (C4)) or 3-4 membered heterocyclyl (e.g., a heterocyclyl containing one 3-4 membered ring and one heteroatom selected from N, O, and S), wherein alkyl, alkoxy, alkylamino, carbocyrill, or heterocyclyl contains one or more R u It may be replaced with .

[0281] In a specific method of operation, each R Y2 It is hydrogen.

[0282] In a particular embodiment, R Y2’ is hydrogen, C 1-6 Alkyl (e.g., methyl (C1), ethyl (C2), n-propyl (C3), i-propyl (C3), n-butyl (C4), i-butyl (C4), s-butyl (C4), t-butyl (C4), pentyl (C5), or hexyl (C6)), C 3-4 Carbocyclyls (e.g., cyclopropyl (C3), cyclopropenyl (C3), cyclobutyl (C4), or cyclobutenyl (C4)), 3-4 membered heterocyclyls (e.g., heterocyclyls containing one 3-4 membered ring and one heteroatom selected from N, O, and S), -S(=O)2R a -S(=O)2OR b -S(=O)2NR c R d -C(=O)R a , -C(=O)OR b , or -C(=O)NR c R d And alkyl, carbocykryl, or heterocyclyl is one or more R u It may be replaced with .

[0283] In a particular embodiment, Z 1 CR Z1 Or it is N.

[0284] In a particular embodiment, R Z1These include hydrogen, halogens (e.g., -F, -Cl, -Br, or -I), -CN, -NO2, -OH, -NH2, and C. 1-6 Alkyl (e.g., methyl (C1), ethyl (C2), n-propyl (C3), i-propyl (C3), n-butyl (C4), i-butyl (C4), s-butyl (C4), t-butyl (C4), pentyl (C5), or hexyl (C6)), C 1-6 Haloalkyl (C15) is a halogen atom independently substituted with one or more halogens, e.g., one, two, or three halogens. 1-6 Alkyl), C 1-6 Alkoxy (e.g., methoxy (C1), ethoxy (C2), propoxy (C3), i-propoxy (C3), n-butoxy (C4), i-butoxy (C4), s-butoxy (C4), t-butoxy (C4), pentoxy (C5), or hexoxy (C6)), C 1-6 Alkylaminos (e.g., dimethylamino, diethylamino, di-n-propylamino, di-i-propylamino, di-n-butylamino, di-i-butylamino, di-s-butylamino, di-t-butylamino, dipentylamino, dihexylamino, methylethylamino, methyl-n-propylamino, methyl-i-propylamino, methyl-n-butylamino, methyl-i-butylamino, methyl-s-butylamino, methyl-t-butylamino, methylpentylamino, methylhexylamino, ethyl-n-propylamino, ethyl-i-propylamino, ethyl-n-butylamino) (No, ethyl-s-butylamino, ethyl-i-butylamino, ethyl-t-butylamino, ethylpentylamino, ethylhexylamino, propyl-n-butylamino, propyl-i-butylamino, propyl-s-butylamino, propyl-t-butylamino, propylpentyrylamino, propylhexylamino, n-butylpentylamino, i-butylpentylamino, s-butylpentylamino, t-butylpentylamino, n-butylhexylamino, i-butylhexylamino, s-butylhexylamino, t-butylpentylamino, n-butylhexylamino, i-butylhexylamino, s-butylhexylamino, t-butylhexylamino, or pentylhexylamino), C 3-4Carbocyclyl (e.g., cyclopropyl (C3), cyclopropenyl (C3), cyclobutyl (C4), or cyclobutenyl (C4)) or 3-4 membered heterocyclyl (e.g., a heterocyclyl containing one 3-4 membered ring and one heteroatom selected from N, O, and S), wherein alkyl, alkoxy, alkylamino, carbocyrill, or heterocyclyl contains one or more R u It may be replaced with .

[0285] In a particular embodiment, R Z1 These include hydrogen, halogens (e.g., -F, -Cl, -Br, or -I), -CN, -NO2, -OH, -NH2, and C. 1-6 Alkyl (e.g., methyl (C1), ethyl (C2), n-propyl (C3), i-propyl (C3), n-butyl (C4), i-butyl (C4), s-butyl (C4), t-butyl (C4), pentyl (C5), or hexyl (C6)), C 1-6 Alkoxy (e.g., methoxy (C1), ethoxy (C2), propoxy (C3), i-propoxy (C3), n-butoxy (C4), i-butoxy (C4), s-butoxy (C4), t-butoxy (C4), pentoxy (C5), or hexoxy (C6)), C 1-6Alkylaminos (e.g., dimethylamino, diethylamino, di-n-propylamino, di-i-propylamino, di-n-butylamino, di-i-butylamino, di-s-butylamino, di-t-butylamino, dipentylamino, dihexylamino, methylethylamino, methyl-n-propylamino, methyl-i-propylamino, methyl-n-butylamino, methyl-i-butylamino, methyl-s-butylamino, methyl-t-butylamino, methylpentylamino, methylhexylamino, ethyl-n-propylamino, ethyl-i-propylamino, ethyl-n-butylamino) (No, ethyl-s-butylamino, ethyl-i-butylamino, ethyl-t-butylamino, ethylpentylamino, ethylhexylamino, propyl-n-butylamino, propyl-i-butylamino, propyl-s-butylamino, propyl-t-butylamino, propylpentyrylamino, propylhexylamino, n-butylpentylamino, i-butylpentylamino, s-butylpentylamino, t-butylpentylamino, n-butylhexylamino, i-butylhexylamino, s-butylhexylamino, t-butylpentylamino, n-butylhexylamino, i-butylhexylamino, s-butylhexylamino, t-butylhexylamino, or pentylhexylamino), C 3-4 Carbocyclyl (e.g., cyclopropyl (C3), cyclopropenyl (C3), cyclobutyl (C4), or cyclobutenyl (C4)) or 3-4 membered heterocyclyl (e.g., a heterocyclyl containing one 3-4 membered ring and one heteroatom selected from N, O, and S), wherein alkyl, alkoxy, alkylamino, carbocyrill, or heterocyclyl contains one or more R u It may be replaced with .

[0286] In a particular embodiment, Z 2 CR Z2 Or it is N.

[0287] In a particular embodiment, R Z2 These include hydrogen, halogens (e.g., -F, -Cl, -Br, or -I), -CN, -NO2, -OH, -NH2, and C. 1-6Alkyl (e.g., methyl (C1), ethyl (C2), n-propyl (C3), i-propyl (C3), n-butyl (C4), i-butyl (C4), s-butyl (C4), t-butyl (C4), pentyl (C5), or hexyl (C6)), C 1-6 Haloalkyl (C15) is a halogen atom independently substituted with one or more halogens, e.g., one, two, or three halogens. 1-6 Alkyl), C 1-6 Alkoxy (e.g., methoxy (C1), ethoxy (C2), propoxy (C3), i-propoxy (C3), n-butoxy (C4), i-butoxy (C4), s-butoxy (C4), t-butoxy (C4), pentoxy (C5), or hexoxy (C6)), C 1-6 Alkylaminos (e.g., dimethylamino, diethylamino, di-n-propylamino, di-i-propylamino, di-n-butylamino, di-i-butylamino, di-s-butylamino, di-t-butylamino, dipentylamino, dihexylamino, methylethylamino, methyl-n-propylamino, methyl-i-propylamino, methyl-n-butylamino, methyl-i-butylamino, methyl-s-butylamino, methyl-t-butylamino, methylpentylamino, methylhexylamino, ethyl-n-propylamino, ethyl-i-propylamino, ethyl-n-butylamino) (No, ethyl-s-butylamino, ethyl-i-butylamino, ethyl-t-butylamino, ethylpentylamino, ethylhexylamino, propyl-n-butylamino, propyl-i-butylamino, propyl-s-butylamino, propyl-t-butylamino, propylpentyrylamino, propylhexylamino, n-butylpentylamino, i-butylpentylamino, s-butylpentylamino, t-butylpentylamino, n-butylhexylamino, i-butylhexylamino, s-butylhexylamino, t-butylpentylamino, n-butylhexylamino, i-butylhexylamino, s-butylhexylamino, t-butylhexylamino, or pentylhexylamino), C 3-4Carbocyclyl (e.g., cyclopropyl (C3), cyclopropenyl (C3), cyclobutyl (C4), or cyclobutenyl (C4)) or 3-4 membered heterocyclyl (e.g., a heterocyclyl containing one 3-4 membered ring and one heteroatom selected from N, O, and S), wherein alkyl, alkoxy, alkylamino, carbocyrill, or heterocyclyl contains one or more R u It may be replaced with .

[0288] In a specific method of operation, each R Z These are independently oxo, hydrogen, halogen (e.g., -F, -Cl, -Br, or -I), -CN, -NO2, -OH, -NH2, C 1-6 Alkyl (e.g., methyl (C1), ethyl (C2), n-propyl (C3), i-propyl (C3), n-butyl (C4), i-butyl (C4), s-butyl (C4), t-butyl (C4), pentyl (C5), or hexyl (C6)), C 1-6 Alkoxy (e.g., methoxy (C1), ethoxy (C2), propoxy (C3), i-propoxy (C3), n-butoxy (C4), i-butoxy (C4), s-butoxy (C4), t-butoxy (C4), pentoxy (C5), or hexoxy (C6)), C 1-6Alkylaminos (e.g., dimethylamino, diethylamino, di-n-propylamino, di-i-propylamino, di-n-butylamino, di-i-butylamino, di-s-butylamino, di-t-butylamino, dipentylamino, dihexylamino, methylethylamino, methyl-n-propylamino, methyl-i-propylamino, methyl-n-butylamino, methyl-i-butylamino, methyl-s-butylamino, methyl-t-butylamino, methylpentylamino, methylhexylamino, ethyl-n-propylamino, ethyl-i-propylamino, ethyl-n-butylamino) (No, ethyl-s-butylamino, ethyl-i-butylamino, ethyl-t-butylamino, ethylpentylamino, ethylhexylamino, propyl-n-butylamino, propyl-i-butylamino, propyl-s-butylamino, propyl-t-butylamino, propylpentyrylamino, propylhexylamino, n-butylpentylamino, i-butylpentylamino, s-butylpentylamino, t-butylpentylamino, n-butylhexylamino, i-butylhexylamino, s-butylhexylamino, t-butylpentylamino, n-butylhexylamino, i-butylhexylamino, s-butylhexylamino, t-butylhexylamino, or pentylhexylamino), C 3-4 Carbocyclyl (e.g., cyclopropyl (C3), cyclopropenyl (C3), cyclobutyl (C4), or cyclobutenyl (C4)) or 3-4 membered heterocyclyl (e.g., heterocyclyl containing one or two 3-4 membered rings and one heteroatom selected from N, O, and S), wherein alkyl, alkoxy, alkylamino, carbocyrill, or heterocyclyl contains one or more R u It may be replaced with .

[0289] In certain embodiments, at least one R Z It is oxo.

[0290] In certain embodiments, z is 0. In certain embodiments, z is 1. In certain embodiments, z is 2, as far as the valence allows. In certain embodiments, z is 3, as far as the valence allows. In certain embodiments, z is 4, as far as the valence allows. In certain embodiments, z is 5, as far as the valence allows. In certain embodiments, z is 6, as far as the valence allows.

[0291] In a particular embodiment, Cy 1 teeth, The filename is TIFF2026521988000250.tif62141.

[0292] In a particular embodiment, Cy 1 teeth, The filename is TIFF2026521988000251.tif15128.

[0293] In a particular embodiment, Cy 2 This is a C6 arylene or a 5-6 membered heteroarylene (e.g., a heteroaryl containing one 5-6 membered ring and 1-4 heteroatoms selected from N, O, and S), and the arylene or heteroarylene contains one or more R u It may be replaced with .

[0294] In a particular embodiment, Cy 2 is one or more R u It is a C6 arylene which may be substituted with Cy. In certain embodiments, Cy 2 This is C6 arrine.

[0295] In a particular embodiment, Cy 2 is one or more R u These are 5- to 6-membered heteroarylenes that may be substituted with (for example, heteroarylenes containing one 5 or 6-membered ring and 1 to 4 heteroatoms selected from N, O, and S).

[0296] In a particular embodiment, Cy 2These are 5-6 membered heteroarylenes (for example, heteroarylenes containing one 5-6 membered ring and 1-4 heteroatoms selected from N, O, and S).

[0297] In a particular embodiment, Cy 2 is one or more R u These are 5- to 6-membered heteroarylenes that may be substituted with (for example, heteroarylenes containing one 5 or 6-membered ring and 1 to 4 heteroatoms selected from N, O, and S).

[0298] In a particular embodiment, Cy 2 It is pyridinylene.

[0299] In a particular embodiment, Cy 2 is one or more R u It is a pyridinylene which may be substituted with

[0300] In a particular embodiment, Cy 2 is one or more halogens, C 1-6 Alkyl, or C 1-6 A pyridinylene which may be substituted with an alkoxy, C 1-6 Alkoxy is composed of one or more C 1-6 It may be substituted with an alkoxy compound.

[0301] In a particular embodiment, Cy 2 teeth, The filename is TIFF2026521988000252.tif16128, and in the formula, TIFF2026521988000253.tif6128 is Cy 1 It shows adhesion to [the surface].

[0302] In a particular embodiment, Cy 2 teeth, TIFF2026521988000254.tif15128, and in the formula, TIFF2026521988000255.tif6128 is Cy 1 It shows adhesion to [the surface].

[0303] In a particular embodiment, Cy 2 teeth, TIFF2026521988000256.tif66134, and in the formula, TIFF2026521988000257.tif6128 is Cy 1 It shows adhesion to [the surface].

[0304] In a particular embodiment, Cy 2 teeth, The file is TIFF2026521988000258.tif14128, and in the formula, ## is Cy 1 It shows adhesion to [the surface].

[0305] In a particular embodiment, L 2 This is CH2. In a particular embodiment, L 2 CH(C 1-3 Alkyl) is. In certain embodiments, L 2 It is CH(CH3).

[0306] In a particular embodiment, L 3 These are E-ethenylene, ethynylene, C6 arylene, or 5-6 member heteroarylene, and E-ethenylene, arylene, or heteroarylene contains one or more R u It may be replaced with .

[0307] In a particular embodiment, L 3 These are E-ethenylene, ethynylene, C6 arylene, or 5-6 membered heteroarylene.

[0308] In a particular embodiment, L 3 is one or more R u It is E-ethenylene which may be substituted with [another compound].

[0309] In a particular embodiment, L 3 This is unsubstituted E-ethenylene.

[0310] In a particular embodiment, L 3 is one or more Ru This is a C6 arylene that may be substituted with [another compound].

[0311] In a particular embodiment, L 3 is one or more R u It is 1,4-phenylene which may be substituted with

[0312] In a particular embodiment, L 3 This is unsubstituted 1,4-phenylene.

[0313] In a particular embodiment, L 3 It is ethynylene.

[0314] In a particular embodiment, L 3 is one or more R u It is a 5-6 member heteroarylene that may be substituted with [another compound].

[0315] In a particular embodiment, L 3 It is an unsubstituted 5-6 member heteroarylene.

[0316] In a specific method of operation, each R a C 1-6 Alkyl (e.g., methyl (C1), ethyl (C2), n-propyl (C3), i-propyl (C3), n-butyl (C4), i-butyl (C4), s-butyl (C4), t-butyl (C4), pentyl (C5), or hexyl (C6)), C 3-6 Carbocyclyl (e.g., cyclopropyl (C3), cyclopropenyl (C3), cyclobutyl (C4), cyclobutenyl (C4), cyclopentyl (C5), cyclopentenyl (C5), cyclohexyl (C6), cyclohexenyl (C6), or cyclohexadienyl (C6)) or 3-6 membered heterocyclyl (e.g., heterocyclyl containing one or two 3-6 membered rings and 1-4 heteroatoms selected from N, O, and S), wherein alkyl, carbocyclyl, or heterocyclyl contains one or more R u It may be replaced with .

[0317] In a particular embodiment, TIFF2026521988000259.tif7128 is, The filename is TIFF2026521988000260.tif9128.

[0318] In a particular embodiment, TIFF2026521988000261.tif7128 is, The filename is TIFF2026521988000262.tif7128.

[0319] In a particular embodiment, L is Selected from the group consisting of TIFF2026521988000263.tif213145.

[0320] In a particular embodiment, L is The filename is TIFF2026521988000264.tif19128.

[0321] In a specific method of operation, each R b Hydrogen and C are independent of each other. 1-6 Alkyl (e.g., methyl (C1), ethyl (C2), n-propyl (C3), i-propyl (C3), n-butyl (C4), i-butyl (C4), s-butyl (C4), t-butyl (C4), pentyl (C5), or hexyl (C6)), C 3-6 Carbocyclyl (e.g., cyclopropyl (C3), cyclopropenyl (C3), cyclobutyl (C4), cyclobutenyl (C4), cyclopentyl (C5), cyclopentenyl (C5), cyclohexyl (C6), cyclohexenyl (C6), or cyclohexadienyl (C6)) or 3-6 membered heterocyclyl (e.g., heterocyclyl containing one or two 3-6 membered rings and 1-4 heteroatoms selected from N, O, and S), wherein alkyl, carbocyclyl, or heterocyclyl contains one or more R u It may be replaced with .

[0322] In a specific method of operation, each R c and each R dHydrogen and C are independent of each other. 1-6 Alkyl (e.g., methyl (C1), ethyl (C2), n-propyl (C3), i-propyl (C3), n-butyl (C4), i-butyl (C4), s-butyl (C4), t-butyl (C4), pentyl (C5), or hexyl (C6)), C 3-6 Carbocyclyl (e.g., cyclopropyl (C3), cyclopropenyl (C3), cyclobutyl (C4), cyclobutenyl (C4), cyclopentyl (C5), cyclopentenyl (C5), cyclohexyl (C6), cyclohexenyl (C6), or cyclohexadienyl (C6)) or 3-6 membered heterocyclyl (e.g., heterocyclyl containing one or two 3-6 membered rings and 1-4 heteroatoms selected from N, O, and S), wherein alkyl, carbocyclyl, or heterocyclyl contains one or more R u It may be replaced with .

[0323] In a particular embodiment, R a , R b , R c , and R d Independently and arbitrarily, one or more R z It has been replaced with.

[0324] In a particular embodiment, R z These are independently oxo, halogen, -CN, -NO2, -OH, -NH2, C 1-6 Alkyl, C 1-6 Alkoxy, C 1-6 Alkylamino, C 3-6 They are carbocyclyls, or 3- to 6-membered heterocyclyls.

[0325] In a specific method of operation, each R u These are independently oxo, halogen, -CN, -NO2, -OH, -NH2, C 1-6 Alkyl (e.g., methyl (C1), ethyl (C2), n-propyl (C3), i-propyl (C3), n-butyl (C4), i-butyl (C4), s-butyl (C4), t-butyl (C4), pentyl (C5), or hexyl (C6)), C 1-6Alkoxy (e.g., methoxy (C1), ethoxy (C2), propoxy (C3), i-propoxy (C3), n-butoxy (C4), i-butoxy (C4), s-butoxy (C4), t-butoxy (C4), pentoxy (C5), or hexoxy (C6)), C 1-6 Alkylaminos (e.g., dimethylamino, diethylamino, di-n-propylamino, di-i-propylamino, di-n-butylamino, di-i-butylamino, di-s-butylamino, di-t-butylamino, dipentylamino, dihexylamino, methylethylamino, methyl-n-propylamino, methyl-i-propylamino, methyl-n-butylamino, methyl-i-butylamino, methyl-s-butylamino, methyl-t-butylamino, methylpentylamino, methylhexylamino, ethyl-n-propylamino, ethyl-i-propylamino, ethyl-n-butylamino) (No, ethyl-s-butylamino, ethyl-i-butylamino, ethyl-t-butylamino, ethylpentylamino, ethylhexylamino, propyl-n-butylamino, propyl-i-butylamino, propyl-s-butylamino, propyl-t-butylamino, propylpentyrylamino, propylhexylamino, n-butylpentylamino, i-butylpentylamino, s-butylpentylamino, t-butylpentylamino, n-butylhexylamino, i-butylhexylamino, s-butylhexylamino, t-butylpentylamino, n-butylhexylamino, i-butylhexylamino, s-butylhexylamino, t-butylhexylamino, or pentylhexylamino), C 3-4 Carbocyclyls (e.g., cyclopropyl (C3), cyclopropenyl (C3), cyclobutyl (C4), or cyclobutenyl (C4)) or 3-6 membered heterocyclyls (e.g., heterocyclyls containing one or two 3-6 membered rings and 1-4 heteroatoms selected from N, O, and S), and alkyl, alkoxy, alkylamino, carbocyclyl, or heterocyclyl are oxo, halogen, -CN, -NO2, -OH, -NH2, C 1-6 Alkyl, C 1-6 Alkoxy, C 1-6 Alkylamino, C 3-4It may be substituted with one or more substituents selected from carbocyclyls and 3- to 4-membered heterocyclyls.

[0326] In a specific method of operation, each R u These are independently oxo, halogen, -CN, -NO2, -OH, -NH2, C 1-6 Alkyl (e.g., methyl (C1), ethyl (C2), n-propyl (C3), i-propyl (C3), n-butyl (C4), i-butyl (C4), s-butyl (C4), t-butyl (C4), pentyl (C5), or hexyl (C6)), C 1-6 Alkoxy (e.g., methoxy (C1), ethoxy (C2), propoxy (C3), i-propoxy (C3), n-butoxy (C4), i-butoxy (C4), s-butoxy (C4), t-butoxy (C4), pentoxy (C5), or hexoxy (C6)), C 1-6 Alkylaminos (e.g., dimethylamino, diethylamino, di-n-propylamino, di-i-propylamino, di-n-butylamino, di-i-butylamino, di-s-butylamino, di-t-butylamino, dipentylamino, dihexylamino, methylethylamino, methyl-n-propylamino, methyl-i-propylamino, methyl-n-butylamino, methyl-i-butylamino, methyl-s-butylamino, methyl-t-butylamino, methylpentylamino, methylhexylamino, ethyl-n-propylamino, ethyl-i-propylamino, ethyl-n-butylamino) (No, ethyl-s-butylamino, ethyl-i-butylamino, ethyl-t-butylamino, ethylpentylamino, ethylhexylamino, propyl-n-butylamino, propyl-i-butylamino, propyl-s-butylamino, propyl-t-butylamino, propylpentyrylamino, propylhexylamino, n-butylpentylamino, i-butylpentylamino, s-butylpentylamino, t-butylpentylamino, n-butylhexylamino, i-butylhexylamino, s-butylhexylamino, t-butylpentylamino, n-butylhexylamino, i-butylhexylamino, s-butylhexylamino, t-butylhexylamino, or pentylhexylamino), C 3-4Carbocyclyls (e.g., cyclopropyl (C3), cyclopropenyl (C3), cyclobutyl (C4), or cyclobutenyl (C4)) or 3-4 membered heterocyclyls (e.g., heterocyclyls containing one 3-4 membered ring and one heteroatom selected from N, O, and S), and alkyl, alkoxy, alkylamino, carbocyclyl, or heterocyclyl are oxo, halogen, -CN, -NO2, -OH, -NH2, C 1-6 Alkyl, C 1-6 Alkoxy, C 1-6 Alkylamino, C 3-4 It may be substituted with one or more substituents selected from carbocyclyls and 3- to 4-membered heterocyclyls.

[0327] Embodiments of the variables in any of the formulas described herein, for example, formulas I, I-1, I-1-i, I-1-i-1, I-1-i-2, I-2, I-3-i, I-3-ii, I-3-iii, I-3-iv, I-3-v, and I-3-vi, are described below as necessary. Any of the variables may be any part described in the embodiments below. Furthermore, combinations of any part described for any of the variables with any part described for any of the remaining variables are also considered as necessary.

[0328] When a range of values ​​is enumerated, each discrete value and subrange within that range is also intended. For example, "C 1-6 "Alkyl" refers to C1, C2, C3, C4, C5, C6, C 1-6 , C 1-5 , C 1-4 , C 1-3 , C 1-2 , C 2-6 , C 2-5 , C 2-4 , C 2-3 , C 3-6 , C 3-5 , C 3-4 , C 4-6 , C 4-5 , and C 5-6 It is intended to include alkyl groups.

[0329] In certain embodiments, the compound is selected from the compounds listed in Tables 1-3 and their pharmaceutically acceptable salts.

[0330] In certain embodiments, the compound is selected from the compounds listed in Tables 1 to 3.

[0331] In certain embodiments, the compound is selected from the compounds in Table 1 and their pharmaceutically acceptable salts.

[0332] In certain embodiments, the compound is selected from the compounds listed in Table 1.

[0333] In certain embodiments, the compound is selected from the compounds in Table 2 and their pharmaceutically acceptable salts.

[0334] In certain embodiments, the compound is selected from the compounds listed in Table 2.

[0335] In certain embodiments, the compound is selected from the compounds in Table 3 and their pharmaceutically acceptable salts.

[0336] In certain embodiments, the compound is selected from the compounds listed in Table 3.

[0337] (Table 1) TIFF2026521988000265.tif83170TIFF2026521988000266.tif87170TIFF2026521988000267.tif109170TIFF2026521988000268.tif107170TIFF2026521988000269.tif90170TIFF2026521988000270.tif84170TIFF2026521988000271.tif92170TIFF2026521988000272.tif87170TIFF2026521988000273.tif110170TIFF2026521988000274.tif109170TIFF2026521988000275.tif109170TIFF2026521988000276.tif84170TIFF2026521988000277.tif89170TIFF2026521988000278.tif79170TIFF2026521988000279.tif79170TIFF2026521988000280.tif79170TIFF2026521988000281.tif79170TIFF2026521988000282.tif79170TIFF2026521988000283.tif93170TIFF2026521988000284.tif79170TIFF2026521988000285.tif79170TIFF2026521988000286.tif79170TIFF2026521988000287.tif86170TIFF2026521988000288.tif79170TIFF2026521988000289.tif79170TIFF2026521988000290.tif79170TIFF2026521988000291.tif79170TIFF2026521988000292.tif80170TIFF2026521988000293.tif80170TIFF2026521988000294.tif80170TIFF2026521988000295.tif80170TIFF2026521988000296.tif80170TIFF2026521988000297.tif76170

[0338] (Table 2) TIFF2026521988000298.tif104170TIFF2026521988000299.tif104170TIFF2026521988000300.tif106170TIFF2026521988 000301.tif103170TIFF2026521988000302.tif110170TIFF2026521988000303.tif80170TIFF2026521988000304.tif101170 TIFF2026521988000305.tif103170TIFF2026521988000306.tif106170TIFF2026521988000307.tif110170TIFF20265219880 00308.tif106170TIFF2026521988000309.tif105170TIFF2026521988000310.tif105170TIFF2026521988000311.tif103170

[0339] (Table 3) TIFF2026521988000312.tif57170

[0340] In certain embodiments, the compounds are selected from compound numbers A6, A15, A16, A41, A45, A46, A66, A70, A71, A79, B1, B5, B30, and B45, as well as their pharmaceutically acceptable salts.

[0341] In a particular embodiment, the compound is selected from compound numbers A6, A15, A16, A41, A45, A46, A66, A70, A71, A79, B1, B5, B30, and B45.

[0342] In certain embodiments, the compounds are selected from compound numbers A6, A15, A16, A41, A45, A46, A66, A70, A71, and A79, as well as their pharmaceutically acceptable salts.

[0343] In a particular embodiment, the compound is selected from compound numbers A6, A15, A16, A41, A45, A46, A66, A70, A71, and A79.

[0344] In certain embodiments, the compounds are selected from compound numbers B1, B5, B30, and B45, as well as their pharmaceutically acceptable salts.

[0345] In certain embodiments, the compound is selected from compound numbers B1, B5, B30, and B45.

[0346] To date, heterobifunctional proteolytic agents have both potential and challenges. The biggest challenge is that, unlike conventional small molecule drugs, proteolytic agents do not satisfy the classic "Rule of Five" (RO5) proposed by Christopher A. Lipinski in 1997: molecular weight (MW) < 500 kDa, solubility (LogP) < 5, H-binding donor (HBD) < 5, H-binding receptor (HBA) < 10, and number of rotatable bonds (nRotB) < 10. Compounds that conform to Lipinski's rule are more likely to have good pharmacokinetic (PK) properties and high oral bioavailability compared to compounds that do not satisfy RO5. Although heterobifunctional proteolytic agents are considered small molecule compounds, they typically violate RO5 due to molecular weight > 500 kDa and several other RO5 parameters exceeding the cutoff. As a result, poor oral malabsorption is a common and major problem for heterobifunctional proteolytic agents.

[0347] To screen for degradation agents with acceptable oral bioavailability, parameters such as molecular weight, solubility, topological polar surface area (tPSA), H-binding donor, H-binding receptor, number of rotatable bonds, and metabolic stability / permeability must be carefully characterized and optimized. Furthermore, selective off-target protein degradation also needs to be optimized. In fact, many current studies recognize the challenge of achieving orally bioavailable compounds and only demonstrate the efficacy and antiproliferative activity of designed degradation agents against targeted protein degradation at the cellular level.

[0348] This disclosure is based, at least in part, on the finding that the compounds disclosed herein may have improved oral bioavailability compared to other p300 degrading agents.

[0349] The compounds of this disclosure may also have advantageous characteristics compared to other p300 degrading agents. For example, the compounds of this disclosure may potentially exhibit p300 selectivity for CBP, stronger degrading activity against p300, and more favorable pharmacokinetic properties (e.g., C max , T max It may exhibit less interaction with other cellular targets (e.g., hepatocyte transporters such as OATP1B1), and / or AUC, and / or other cellular targets, as well as improved safety (e.g., drug-drug interactions) accordingly.

[0350] In certain embodiments, the compounds disclosed herein have a CBP DC when both values ​​are measured at the same time. 50 DC lower than p300 50 If present, it exhibits selective degradation of p300 compared to CBP. In certain embodiments, the compounds disclosed herein exhibit selective degradation of p300 compared to CBP when both values ​​are measured at the same time. max D compared to p300 which is larger max If it has, it exhibits selectivity. In certain embodiments, the compounds disclosed herein have a smaller DC of p300 compared to CBP. 50 and larger D max It exhibits selectivity through both combinations. In certain embodiments, the compounds disclosed herein are compounds whose DC of CBP 50 The DC of the p300 is at least 10 times smaller than 50 , and / or at least 30, at least 35, at least 40, or at least 45 percent points of p300 D max From CBP's D max The value obtained by subtracting (ΔD max) exhibits selectivity. In certain preferred embodiments, the compounds disclosed herein are CBP DC 50 The DC of the p300 is at least 30 times smaller than 50 , and / or at least 50, at least 55, at least 60, or at least 65 percent points of p300 D max From CBP's D max The value obtained by subtracting (ΔD max ) exhibits selectivity. In certain more preferred embodiments, the compounds disclosed herein are CBP's DC 50 The DC of the p300 is at least about 100 times smaller than 50 , and / or at least 70, at least 75, at least 80, at least 85, or at least 90 percent points of p300 D max From CBP's D max The value obtained by subtracting (ΔD max If it has ), it exhibits selectivity. In certain embodiments, the compounds disclosed herein have a significantly longer time point (e.g., 24 hours) of CBP D max D of p300 measured at a shorter time point (e.g., 2 hours) is equivalent to or greater than that. max If it has, it exhibits selectivity. In certain preferred embodiments, the compound exhibits selectivity at least 30, at least 40, at least 50, at least 60, at least 70, at least 80, or at least 90 percent points (ΔD) even when strictly measured (2 hours for p300 and 48 hours for CBP). max ) are possessed. These beneficial properties of the compounds of this disclosure can be measured according to methods commonly available in the art, such as the methods exemplified herein.

[0351] Due to the presence of the double bond, the compounds of this disclosure may be in a cis or trans, or Z or E configuration. Naturally, one configuration may be illustrated in the structure of the compounds or formulas of this disclosure, but this disclosure also encompasses other configurations. For example, the compounds or formulas of this disclosure may be represented in a cis or trans, or Z or E configuration.

[0352] In one embodiment, the compounds of the Disclosure (e.g., any of the compounds of the formulas disclosed herein or any individual compounds) are pharmaceutically acceptable salts. In another embodiment, the compounds of the Disclosure (e.g., any of the compounds of the formulas disclosed herein or any individual compounds) are solvates. In yet another embodiment, the compounds of the Disclosure (e.g., any of the compounds of the formulas disclosed herein or any individual compounds) are hydrates. Pharmaceutically acceptable salts

[0353] In certain embodiments, the compounds disclosed herein exist as pharmaceutically acceptable salts thereof. In certain embodiments, the methods disclosed herein include methods for treating a disease by administering such pharmaceutically acceptable salts. In certain embodiments, the methods disclosed herein include methods for treating a disease by administering such pharmaceutically acceptable salts as a pharmaceutical composition.

[0354] In certain embodiments, the compounds described herein have acidic or basic groups and therefore react with a number of inorganic or organic bases, as well as inorganic and organic acids, to form pharmaceutically acceptable salts. In certain embodiments, these salts are prepared by reacting the purified compounds separately with suitable acids or bases, either in situ during the final isolation and purification of the compounds disclosed herein, or in their free form, and then isolating the salts thus formed.

[0355] Examples of pharmaceutically acceptable salts include salts prepared by the reaction of the compounds described herein with minerals, organic acids, or inorganic bases, such as acetates, acrylates, adipicates, alginates, aspartates, benzoates, benzenesulfons, bisulfates, bisulfites, bromides, butyrates, butynate-1,4-diates, camphorates, camphor sulfons, caproates, caprylates, chlorobenzoates, chlorides, citrates, cyclopentanepropionates, decanoates, diglucons, dihydrogen phosphates, dinitrobenzoates, dodecyl sulfates, ethanesulfons, formates, fumarates, glucoheptanoates, glycerophosphates, glycolates, hemisulfates, heptanoates, hexanoates, hexine-1,6-diates, hydroxybenzoates, γ-hydroxybutyrates, hydrochlorides, and hydrobromic acids. This includes salts, hydroiodide, 2-hydroxyethanesulfonate, iodide, isobutyrate, lactate, maleate, malonate, methanesulfonate, mandelate, metaphosphate, methanesulfonate, methoxybenzoate, methylbenzoate, monohydrogen phosphate, 1-naphthalenesulfonate, 2-naphthalenesulfonate, nicotinate, nitrate, palmitate, pectinate, persulfate, 3-phenylpropionate, phosphate, picrate, pivalate, propionate, pyrosulfate, pyrophosphate, propiolate, phthalate, phenylacetate, phenylbutyrate, propanesulfonate, salicylate, succinate, sulfate, sulfite, succinate, suberinate, sebacinate, sulfonate, tartrate, thiocyanate, tosylate-undeconeate, and xylenesulfonate.

[0356] Furthermore, the compounds described herein may be prepared as pharmaceutically acceptable salts formed by reacting the free base form of the compounds with a pharmaceutically acceptable inorganic or organic acid, such as inorganic acids (e.g., hydrochloric acid, hydrobromic acid, sulfuric acid, nitric acid, phosphoric acid, metaphosphoric acid, etc.) and organic acids (e.g., acetic acid, propionic acid, hexanoic acid, cyclopentanepropionic acid, glycolic acid, pyruvic acid, lactic acid, malonic acid, succinic acid, malic acid, maleic acid, fumaric acid, p-toluenesulfonic acid, tartaric acid, trifluoroacetic acid, citric acid, benzoic acid, 3-(4-hydroxybenzoyl)benzoic acid, cinnamic acid, mandelic acid, arylsulfonic acid, methanesulfonic acid, ethanesulfonic acid, 1,2-ethanedisulfonic acid, 2-hydroxyethanesulfonic acid) Examples include, but are not limited to, acids (benzenesulfonic acid, 2-naphthalenesulfonic acid, 4-methylbicyclo-[2.2.2]octa-2-ene-1-carboxylic acid, glucoheptonic acid, 4,4'-methylenebis-(3-hydroxy-2-ene-1-carboxylic acid), 3-phenylpropionic acid, trimethylacetic acid, tertiary butylacetic acid, lauryl sulfate, gluconic acid, glutamic acid, hydroxynaphthoic acid, salicylic acid, stearic acid, and muconic acid).

[0357] In certain embodiments, compounds described herein containing a free acid group react with a suitable base such as a pharmaceutically acceptable metal cation hydroxide, carbonate, bicarbonate, or sulfate, with ammonia, or with a pharmaceutically acceptable organic primary, secondary, tertiary, or quaternary amine. Typical salts include alkali salts or alkaline earth salts such as lithium, sodium, potassium, calcium, magnesium, and aluminum salts. Exemplary examples of bases include sodium hydroxide, potassium hydroxide, choline hydroxide, sodium carbonate, and N2. + (C 1-4 Examples include alkyl(4) and others.

[0358] Representative organic amines useful for the formation of base addition salts include ethylamine, diethylamine, ethylenediamine, ethanolamine, diethanolamine, and piperazine. It should be understood that the compounds described herein also involve quaternization of any basic nitrogen-containing group they contain. In certain embodiments, aqueous, oil-soluble, or dispersible products are obtained by such quaternization. solvate

[0359] A “solvate” typically refers to a form of compound associated with a solvent or water (also called a “hydrate”), usually obtained by solvolysis. This physical bonding includes hydrogen bonding. Conventional solvents include water, ethanol, and acetic acid. The compounds of this disclosure may be prepared, for example, in crystalline form and may be solvated or hydrated. Preferred solvates include pharmaceutically acceptable solvates such as hydrates, and further include both stoichiometric and non-stoichiometric solvates. In certain examples, solvates can be isolated, for example, when one or more solvent molecules are incorporated into the crystal lattice of a crystalline solid. “Solvates” encompass both solution-phase solvates and isolateable solvates. Representative solvates include hydrates, ethanol adducts, and methanol adducts.

[0360] Those skilled in organic chemistry will understand that many organic compounds can form complexes with solvents, either by reacting with them or by precipitating or crystallizing them. These complexes are known as “solvates.” For example, a complex with water is known as a “hydrate.” Solvates are within the scope of this disclosure.

[0361] Furthermore, it will be understood by those skilled in organic chemistry that many organic compounds can exist in two or more crystalline forms. For example, the crystalline form may differ depending on the solvate. Therefore, all crystalline forms or their pharmaceutically acceptable solvates are intended and are within the scope of this disclosure.

[0362] In certain embodiments, the compounds described herein exist as solvates. This disclosure provides a method for treating a disease by administering such solvates. This disclosure further provides a method for treating a disease by administering such solvates as pharmaceutical compositions.

[0363] Solvates contain either stoichiometric or non-stoichiometric amounts of a solvent, such as water or ethanol. A hydrate is formed when the solvent is water, or an alcoholate is formed when the solvent is alcohol. Solvates of the compounds described herein can be conveniently prepared or formed during the processes described herein. Furthermore, the compounds provided herein may exist in both solvated and unsolvated forms. Generally, the solvated form is considered equivalent to the unsolvated form for the purposes of the compounds and methods provided herein. Isomers (stereoisomers, geometric isomers, tautomers, etc.)

[0364] It should be understood that compounds having the same molecular formula but differing in the properties or arrangement of their atomic bonds, or in the spatial arrangement of those atoms, are also called "isomers." Isomers that differ in the spatial arrangement of their atoms are called "stereoisomers."

[0365] Stereoisomers that are not mirror images of each other are called "diastereomers," while stereoisomers that are mirror images of each other but cannot be superimposed are called "enantiomers." If a compound has a chiral center, for example, if it is bonded to four different groups, a pair of enantiomers is possible. Enantiomers can be characterized by the absolute configuration of their chiral center, by the Kahn and Prelog R and S sequencing rules, or by the way the molecule rotates its plane of polarization and is designated as dextrorotatory or levorotatory (i.e., as (+) or (-) isomers, respectively). Chiral compounds can exist as individual enantiomers or as mixtures thereof. A mixture containing equal proportions of enantiomers is called a "racemic mixture."

[0366] As used herein, a pure enantiomer compound is substantially free of other enantiomers or stereoisomers of the compound (i.e., enantiomer-rich). In other words, the “S” form of a compound is substantially free of the “R” form of the compound and is therefore the enantiomer-rich “R” form. The terms “enantiomerically pure” or “pure enantiomer” indicate that the compound contains more than 95% by weight, more than 96% by weight, more than 97% by weight, more than 98% by weight, more than 98.5% by weight, more than 99% by weight, more than 99.2% by weight, more than 99.5% by weight, more than 99.6% by weight, more than 99.7% by weight, more than 99.8% by weight, or more than 99.9% by weight of enantiomers. In certain embodiments, weight is based on the total weight of all enantiomers or stereoisomers of the compound.

[0367] As used herein, and unless otherwise indicated, the term “enantiomerically pure (R)-compound” means at least about 95% by weight of the (R)-compound and up to about 5% by weight of the (S)-compound, at least about 99% by weight of the (R)-compound and up to about 1% by weight of the (S)-compound, or at least about 99.9% by weight of the (R)-compound and up to about 0.1% by weight of the (S)-compound. In certain embodiments, weight is based on the total weight of the compound.

[0368] As used herein, and unless otherwise indicated, the term “enantiomerically pure (S)-compound” means at least about 95% by weight of the (S)-compound and up to about 5% by weight of the (R)-compound, at least about 99% by weight of the (S)-compound and up to about 1% by weight of the (R)-compound, or at least about 99.9% by weight of the (S)-compound and up to about 0.1% by weight of the (R)-compound. In certain embodiments, weight is based on the total weight of the compound.

[0369] In the compositions provided herein, enantiomerically pure compounds, or pharmaceutically acceptable salts, solvates, hydrates, or prodrugs thereof, may be present together with other active or inactive components. For example, a pharmaceutical composition containing an enantiomerically pure (R)-compound may, for example, consist of about 90% excipients and about 10% enantiomerically pure (R)-compound. In certain embodiments, the enantiomerically pure (R)-compound in such a composition may consist, for example, by total weight of the compound, at least about 95% by weight of the (R)-compound and up to about 5% by weight of the (S)-compound. For example, a pharmaceutical composition containing an enantiomerically pure (S)-compound may, for example, consist of about 90% excipients and about 10% enantiomerically pure (S)-compound. In certain embodiments, the enantiomerically pure (S)-compound in such a composition may consist, for example, at least about 95% by weight of the (S)-compound and up to about 5% by weight of the (R)-compound by the total weight of the compound. In certain embodiments, the active ingredient may be formulated with little or no excipients or carriers.

[0370] Unless otherwise indicated, the descriptions or nomenclas of specific compounds in this specification and the claims are intended to include both individual enantiomers and mixtures thereof, racemates, or others. Methods for determining stereochemistry and separating stereoisomers are well known in the art.

[0371] In certain embodiments, the compounds described herein exist as geometric isomers. In certain embodiments, the compounds described herein have one or more double bonds. The compounds disclosed herein include all cis, trans, syn, anti, entgegen (E), and tuzamen (Z) isomers, as well as their corresponding mixtures. All geometric forms of the compounds disclosed herein are contemplated and are within the scope of this disclosure.

[0372] In certain embodiments, the compounds disclosed herein have one or more chiral centers, each center existing in either an R or S configuration. The compounds disclosed herein include all diastereomers, enantiomers, and epimers, as well as their corresponding mixtures. All diastereomers, enantiomers, and epimers of the compounds disclosed herein are intended and are within the scope of this disclosure.

[0373] In further embodiments of the compounds and methods provided herein, mixtures of enantiomers and / or diastereomers resulting from a single preparation step, combination, or interconversion are useful for the applications described herein. In certain embodiments, the compounds described herein are prepared as their individual stereoisomers by reacting a racemic mixture of the compounds with an optically active resolving agent to form a pair of diastereomer compounds, separating the diastereomers, and collecting the optically pure enantiomers. In certain embodiments, dissociable complexes are preferred. In certain embodiments, the diastereomers have distinct physical properties (e.g., melting point, boiling point, solubility, reactivity, etc.) and are separated by utilizing these differences. In certain embodiments, the diastereomers are separated by chiral chromatography, or preferably by separation / resolving techniques based on differences in solubility. In certain embodiments, the optically pure enantiomers are then collected together with the resolving agent. Tautomers

[0374] In certain embodiments, the compounds described herein exist as tautomers. The compounds described herein include all possible tautomers in the formulas described herein.

[0375] Tautomers are compounds that can be interconverted by the movement of hydrogen atoms, involving the switching of single bonds and adjacent double bonds. A chemical equilibrium of tautomers exists in bond configurations where tautomerization is possible. For example, enols and ketones are tautomers because they are rapidly interconverted by treatment with either an acid or a base. Another example of tautomerism is the ac and nitro forms of phenylnitromethane, similarly formed by treatment with an acid or a base. The tautomer form may be relevant to achieving the optimal chemical reactivity and biological activity of the compound of interest. All tautomer forms of the compounds disclosed herein are intended and within the scope of this disclosure. The exact ratio of tautomers depends on several factors, including temperature, solvent, and pH. Pharmaceutical composition

[0376] In certain embodiments, the compounds described herein are administered as pure chemical substances. In certain embodiments, the compounds described herein are, for example, as described in Remington: The Science and Practice of Pharmacy (Gennaro, 21 st It is combined with one or more pharmaceutically suitable or acceptable carriers (hereinafter also referred to herein as one or more pharmaceutically suitable (or acceptable) excipients, physiologically suitable (or acceptable) excipients, or physiologically suitable (or acceptable) carriers) selected based on the selected routes of administration and standard pharmacopoeias described in Ed. Mack Pub. Co., Easton, PA (2005)).

[0377] Accordingly, this disclosure provides pharmaceutical compositions comprising a compound described herein, or a pharmaceutically acceptable salt, solvate, or stereoisomer thereof, and a pharmaceutically acceptable excipient.

[0378] In certain embodiments, the compounds provided herein are substantially pure in that they contain less than about 5%, less than about 1%, or less than 0.1% of other small organic molecules, such as unreacted intermediates or synthetic byproducts generated in one or more steps of the synthesis method.

[0379] Pharmaceutical compositions are administered in a manner appropriate to the disease being treated (or prevented). The appropriate dose, as well as the preferred duration and frequency of administration, are determined by factors such as the patient's condition, the type and severity of the patient's disease, the specific form of the active ingredient, and the method of administration. Generally, an appropriate dose and treatment regimen provides the composition in an amount sufficient to deliver therapeutic and / or preventive benefits (e.g., more frequent complete or partial remission, longer disease-free and / or overall survival, or improved clinical outcomes such as reduced symptom severity). The optimal dose is generally determined using experimental models and / or clinical trials. The optimal dose depends on the patient's body weight, weight, or blood volume.

[0380] In certain embodiments, the pharmaceutical composition is formulated for oral, topical (including buccal and sublingual), rectal, vaginal, transdermal, parenteral, intrapulmonary, intradermal, intrathecal and epidural, and intranasal administration. Parenteral administration includes intramuscular, intravenous, intra-arterial, intraperitoneal, or subcutaneous administration. In certain embodiments, the pharmaceutical composition is formulated for intravenous injection, oral administration, inhalation, intranasal administration, topical administration, or ophthalmic administration. In certain embodiments, the pharmaceutical composition is formulated for oral administration. In certain embodiments, the pharmaceutical composition is formulated for intravenous injection. In certain embodiments, the pharmaceutical composition is formulated as tablets, pills, capsules, liquids, inhalants, nasal spray solutions, suppositories, suspensions, gels, colloids, dispersions, suspensions, solutions, emulsions, ointments, lotions, eye drops, or ear drops. In certain embodiments, the pharmaceutical composition is formulated as tablets. Preparation and characterization of compounds

[0381] The compounds of this disclosure can be prepared by several methods well known to those skilled in the art of organic synthesis. For example, the compounds of this disclosure can be synthesized using the methods described below, along with synthetic methods known in the art of synthetic organic chemistry, or variations thereof, as will be understood by those skilled in the art. The compounds of this disclosure (i.e., the compounds of this application (e.g., any of the compounds of the formulas disclosed herein or any individual compounds)) can be synthesized by following the general synthetic scheme described below, as well as the examples, schemes, procedures, and / or steps outlined in this specification (e.g., Examples). General synthesis scheme

[0382] The compound of formula I-1' may be prepared according to the procedure shown in scheme 1A. TIFF2026521988000313.tif38128

[0383] According to Scheme 1A, a commercially available or easily synthesized substituted arene of formula I-1'-1a is reacted with a commercially available or easily synthesized substituted bromide of formula I-1'-2a at a temperature in the range of 60°C to 100°C, preferably 60°C, using a suitable organic base (such as TEA, DIPEA, DBU, and similar), to obtain a compound of formula I-1'.

[0384] R D1 The compound of formula I-1', where =H, may alternatively be prepared according to the procedure shown in scheme 1B. TIFF2026521988000314.tif77128

[0385] According to Scheme 1B, a commercially available or easily synthesized substituted arene I-1'-1b (Y=Cl, Br, I, OTf, or similar) is used with a suitable palladium catalyst (such as Pd(dppf)Cl2, Pd(PPh3)4, Pd X-Phos G2, or similar) and a suitable base (Na2CO3, Cs2CO3, K3PO4, KO). tThe compound of formula I-1'-3b is obtained by bonding commercially available or easily synthesized substituted pyridine I-1'-2b (U=H, B(OR)2, ZnCl, SnR3, or similar) with or without Bu (such as Bu) in a suitable solvent (such as dioxane, THF, DMF, toluene (mixed with water or anhydrous), or similar) at a temperature in the range of 40°C to 120°C, according to standard Buchwald-Hartwig conditions, standard Suzuki-Miyaura conditions, standard Negishi conditions, standard Still conditions, or similar. Next, the bis(benzyloxy)pyridine of formula I-1'-3b is reduced using a suitable inorganic catalyst (such as Pd / C, Pd(OH)2, or similar) in a suitable solvent (such as EtOH, MeOH, or similar) and a suitable hydride source (such as an H2 atmosphere) at a temperature in the range of 40°C to 120°C to obtain the compound of formula I-1'.

[0386] The compound of formula I-3-i may be prepared according to the procedure shown in scheme 2. TIFF2026521988000315.tif92130

[0387] According to Scheme 2, a commercially available or easily synthesized substituted nitro compound of formula I-3-i-1 is reacted with a vinyl Grignard agent of formula I-3-i-2 (X=Br, Cl or I) and similar agents in a suitable solvent (such as THF, dioxane, and similar agents) at a temperature in the range of -60°C to 25°C to obtain a cyclized compound of formula I-3-i-3. The cyclized compound of formula I-3-i-3 is acylated with commercially available 2,2,2-trichloroacetyl chloride using a suitable Lewis acid (such as AlCl3, BF3 etherate, and similar agents) in a suitable solvent (such as DCM, dichloroethane, and similar agents) at a temperature in the range of 0°C to 60°C, preferably 25°C, to obtain an acylated compound of formula I-3-i-4. The acylated compound of formula I-3-i-4 is hydrolyzed in a suitable mixed solvent (such as THF mixed with water, MeOH, and similar substances) at a temperature in the range of 25°C to 80°C using a suitable inorganic base (such as KOH, NaOH, and similar substances) to obtain the acid of formula I-3-i-5. Next, the acid of formula I-3-i-5 is acylated with a suitable chlorine source (such as SOCl2 or oxalyl chloride and similar substances) in a suitable solvent (such as DCM, dichloroethane, and similar substances) at a temperature in the range of 0°C to 80°C using a catalyst (such as DMF and similar substances) to obtain the chloride acyl compound of formula I-3-i-6. The acyl chloride compound of formula I-3-i-6 is combined with a commercially available or easily synthesized amine source using a suitable organic base (TEA, DIPEA, or similar) in a suitable solvent (such as DCM, THF, and similar) at a temperature in the range of -10°C to 20°C to form formula I-3-i(R F4 Obtain the amide of (=amide).

[0388] The compound of formula I-3-ii may be prepared according to the procedure shown in scheme 3. TIFF2026521988000316.tif72137

[0389] According to Scheme 3, a commercially available or easily synthesized bis-aniline of formula I-3-ii-1 is reacted with a carbon monoxide insertion agent (CDI, triphosgene, or similar) using an organic base (such as TEA or DIPEA or similar) in a suitable solvent (such as DCM, DMF, or similar) at a temperature in the range of 0°C to 60°C to obtain a urea compound of formula I-3-ii-2. The urea compound of formula I-3-ii-2 is alkylated in a suitable solvent (such as DMF, THF, or similar) at a temperature in the range of 0°C to 60°C, preferably 40°C, using a suitable inorganic base (such as NaH, t-BuOK, or similar) and a commercially available or easily synthesized substituted alkyl halide to obtain a substituted urea compound of formula I3-ii-3. A urea compound of formula I-3-ii-3 (X = halide) is reacted with a commercially available or easily synthesized substituted alkyl or vinyl borate (Suzuki), zinc (Negishi), or magnesium (Kumada) agent I-3-ii-4 in an inorganic base (Na2CO3, K3PO4, etc.) and a suitable solvent (THF, dioxane, etc.) using a suitable catalyst (Pd(Ph3P)4, PdCl2(Ph3P)2, and similar agents) at a temperature in the range of 0°C to 100°C, preferably 40°C, to obtain a substituted compound of formula I3-ii.

[0390] The compound of formula I-3-iii may be prepared according to the procedure shown in scheme 4. TIFF2026521988000317.tif60129

[0391] According to Scheme 4, a commercially available or easily synthesized substituted arylnitro compound of formula I-3-iii-1 is reacted with a commercially available or easily synthesized substituted amino acid of formula I-3-iii-2 using a suitable inorganic base (such as K2CO3, Cs2CO3, and the like) in a suitable solvent (such as DMF, DMSO, and the like) at a temperature in the range of 50°C to 120°C to obtain a compound of formula I-3-iii-3. The nitro compound of formula I-3-iii-3 is reduced in an acidic solvent (such as HOAc, 1N HCl aqueous solution, and the like) at a temperature in the range of 80°C to 120°C, preferably 100°C, using a suitable reducing agent (such as Fe, SnCl2, and the like) to obtain a cyclized compound of formula I-3-iii.

[0392] The compound of formula I-3-iv may be prepared according to the procedure shown in scheme 5. TIFF2026521988000318.tif89131

[0393] According to Scheme 5, a commercially available or easily synthesized substituted ketoester compound of formula I-3-iv-1 is alkylated with a commercially available or easily synthesized substituted bromoester of formula I-3-iv-2 using a suitable inorganic base (such as K2CO3, Cs2CO3, and the like) in a suitable solvent (such as acetone, DMF, DMSO, and the like) at a temperature in the range of 50°C to 120°C to obtain a compound of formula I-3-iv-3. The ketoester compound of formula I-3-iv-3 is decarboxylated using a suitable acid (such as HCl, H2SO4, and the like) in an acidic solvent (such as HOAc, 1N HCl aqueous solution, and the like) at a temperature in the range of 40°C to 100°C, preferably 60°C, to obtain a keto acid compound of formula I-3-iv-4. The keto acid compound of formula I-3-iv-4 is coupled with a commercially available or easily synthesized substituted aminoester compound of formula I-3-iv-5 in a suitable solvent (DMF, DMSO, etc.) at a temperature in the range of 0°C to 80°C using a suitable coupling agent (T3P, HATU, etc.) to obtain the bonded compound of formula I-3-iv-6. The bonded compound of formula I-3-iv-6 is cyclized under adrol condensation conditions using a suitable base (LDA, LiHMDS, etc.) in a suitable solvent (THF, dioxane, etc.) at a temperature in the range of -78°C to 0°C to obtain the cyclized keto-enol compound of formula I-3-iv-7. The keto-enol compound of formula I-3-iv-7 is reacted with a commercially available or easily synthesized substituted hydrazine compound of formula I-3-iv-8 in a suitable solvent (such as MeOH, EtOH, and similar) at a temperature in the range of 25°C to 80°C to obtain the conjugated compound of formula I-3-iv.

[0394] Compounds of formula I-3-v may also be prepared according to the procedure shown in scheme 6. TIFF2026521988000319.tif57141

[0395] According to Scheme 6, a commercially available or easily synthesized substituted amine compound of formula I-3-v-1 is coupled with a commercially available or easily synthesized substituted acid of formula I-3-v-2 using a suitable coupling agent (such as HATU, T3P, and the like), a suitable organic base (such as TEA, DIPEA, and the like), in a suitable solvent (such as DMF, DMSO, and the like) at a temperature in the range of 0°C to 80°C to obtain a bonded amide compound of formula I-3-v-3. The amide compound of formula I-3-v-3 is cyclized in an aprotic polar solvent (such as DMF, and the like) at a temperature in the range of 60°C to 100°C, preferably 80°C, using a suitable reactive chloride source (such as POCl3, SOCl2, and the like) to obtain a cyclized pyrazine compound of formula I-3-v-4. The cyclized pyrazine compound of formula I-3-v-4 is reduced using a suitable catalyst (such as 10% Pd / C, Pd(OH)2 / C, and similar) in a suitable solvent (such as siRNA, MeOH, and similar) at a temperature in the range of 25°C to 80°C, with a suitable reducing agent (such as H2 gas at a maximum of 50 psi, ammonium formate, and similar), to obtain the reduced compound of formula I-3-v-5. The reduced compound of formula I-3-v-5 is acylated using a commercially available or easily synthesized acylating agent of formula I-3-v-6 in a suitable organic base (such as TEA, DIPEA, and similar) in a suitable solvent (such as DCM, dichloroethane, and similar), at a temperature in the range of -10°C to 25°C, to obtain the acylated compound of formula I-3-v.

[0396] Compounds of formula I-3-vi-a or I-3-vi-b may also be prepared according to the procedure shown in Scheme 7. TIFF2026521988000320.tif48136

[0397] According to Scheme 7, a commercially available or easily synthesized substituted aniline of formula I-3-vi-a-1 or I-3-vi-b-1 is reacted with a commercially available or easily synthesized acyl halide of formula I-3-vi-2 (X=Cl or Br) using a suitable organic base (TEA, DIPEA, and similar) in a suitable solvent (DCM, dichloroethane, and similar) at a temperature in the range of -10°C to 50°C to obtain a compound of formula I-3-vi-a-3 or I-3-vi-b-3. The acylated compound of formula I-3-vi-a-3 or I-3-vi-b-3 is reduced using a suitable chlorine source (POCl3, SOCl2, and similar) in an aprotic polar solvent (DMF, and similar) at a temperature in the range of 0°C to 80°C to obtain a cyclized compound of formula I-3-vi-a-4 or I-3-vi-b-4. An aryl chloride compound of formula I-3-vi-a-4 or I-3-vi-b-4 is hydrolyzed in an aqueous solution in a mixed solvent (such as MeOH and similar substances) at a temperature in the range of 0°C to 60°C using a suitable base (such as NaOH, KOH and similar substances) to obtain a cyclized compound of formula I-3-vi-a or I-3-vi-b.

[0398] The compound of formula I-2 may be prepared according to the procedure shown in scheme 8. TIFF2026521988000321.tif45142

[0399] According to Scheme 8, a commercially available or easily synthesized substituted aryl halide of formula I-2'-1 (X=Cl, Br, or OTf) is reacted with a commercially available or easily synthesized aryl metal agent of formula I-2'-2 (Y=B, Zn, or Mg) in a suitable solvent (dioxane, DMF, or similar) at a temperature in the range of 60°C to 100°C, with or without an inorganic base (Na2CO3, K3PO4, or similar), using a suitable catalyst (such as Pd(Ph3P)4, PdCl2dppf, or similar), to obtain a compound of formula I-2'-3. The ester of formula I-2'-3 is reacted with a reagent suitable for saponification (such as LiOH, or similar) in a suitable solvent (such as THF mixed with water, or similar), at a temperature in the range of 0°C to 60°C, preferably at room temperature, to obtain a carboxylic acid of formula I-2'-4. The acid of formula I-2'-4 is reacted with a commercially available or easily synthesized substituted amine of formula I-2'-5 in an organic solvent (such as DCM, DMF, and similar) at a temperature in the range of 0°C to 60°C using a coupling agent (such as HATU, T3P, and similar) to obtain the bound amide compound of formula I-2'.

[0400] The compound of formula I may be prepared according to the procedure shown in scheme 9. TIFF2026521988000322.tif20128

[0401] According to Scheme 9, a readily synthesized substituted aryl halide (Cl, Br, or OTf) as the target ligand for formula T can be synthesized using a suitable catalyst (such as Pd(Ph3P)4, PdCl2dppf, and similar) (Suzuki), or a suitable catalyst (such as Pd2(dba)3, Pd(OAc)2, and similar) (Buchwald), and an inorganic base (Na2CO3, K3PO3). 4、The bound compound of formula TL is obtained by reacting L (linker) (boronic acid ester, Zn or Mg halide) (with or without t-BuONa and similar substances) in a suitable solvent (dioxane, DMF and similar substances) at a temperature in the range of 60°C to 120°C, with or without an organic base (TEA, DIPEA and similar substances). The bound compound of formula TL (target ligand and linker) is reacted with a commercially available or easily synthesized E3 ligand of formula C at a temperature in the range of 0°C to 100°C, with or without an organic base (TEA, DIPEA and similar substances), by Suzuki coupling catalyzed by Pd(Ph3P)4, PdCl2dppf and similar substances, or by coupling catalyzed by PdCl2(Ph3P)2 and CuI and similar substances, in an organic solvent (dioxane, DMF and similar substances), with or without an organic base (TEA, DIPEA and similar substances), to obtain a decomposition agent compound bound to formula TLC(I). Those skilled in the art will recognize that these steps may be reversed depending on the particular compound. They will also recognize that these steps may be interspersed among those described in schemes 1-8 above, as long as the reactivity of the particular compound allows.

[0402] Those skilled in the art will recognize whether a stereocenter exists in any of the compounds of this disclosure (e.g., any of the compounds of the formulas disclosed herein or any individual compound). Therefore, this disclosure includes both possible stereoisomers (unless otherwise specified in synthesis) and individual enantiomers and / or diastereomers, as well as racemic compounds. Where a compound is desired as a single enantiomer or diastereomer, it may be obtained by stereospecific synthesis or by the separation of the final product or any convenient intermediate. The separation of the final product, intermediate, or starting material may be influenced by any suitable method known in the art. See, for example, “Stereochemistry of Organic Compounds” by EL Eliel, SH Wilen, and LN Mander (Wiley-Interscience, 1994).

[0403] The compounds used in the reactions described herein are prepared by starting from commercially available chemicals and / or compounds described in the chemical literature, according to organic synthesis techniques known to those skilled in the art. “Commercially available chemicals” are obtained from standard commercial suppliers, including Acros Organics (Pittsburgh, Pennsylvania) and Aldrich Chemical (Milwaukee, Wisconsin, including Sigma Chemical and Fluka) (Pittsburgh, Pennsylvania).

[0404] Suitable references and papers that detail the synthesis of reactants useful for the preparation of the compounds described herein, or provide references to articles describing the preparations, include, for example, “Synthetic Organic Chemistry”, John Wiley & Sons, Inc., New York; SR Sandler et al., “Organic Functional Group Preparations”, 2nd Ed., Academic Press, New York, 1983; HO House, “Advanced Organic Chemistry: Reactions, Mechanisms and Structure”, 4th Ed., Wiley-Interscience, New York, 1992; and “Chemistry of Functional Groups”, John Wiley & Sons, in 73 volumes.

[0405] Specific and similar reactants are selectively identified through indicators of known chemicals prepared by the Chemical Abstract Service of the American Chemical Society, which are available in most public and university libraries, as well as online. Known chemicals not commercially available in catalogs are selectively prepared by custom chemical synthesis companies, many of which are standard chemical suppliers (e.g., those listed above). A reference for the preparation and selection of pharmaceutical salts of the compounds described herein is P.H. Stahl & CG Wermuth, “Handbook of Pharmaceutical Salts”, Verlag Helvetica Chimica Acta, Zurich, 2002. Analytical methods, materials, and equipment

[0406] Unless otherwise noted, reagents and solvents were used in the condition they were received from the commercial supplier. Proton nuclear magnetic resonance (NMR) spectra were obtained using either a 400 MHz Bruker or Varian spectrometer. Spectra are shown in ppm(δ), and the coupling constant J is reported in Hertz. Tetramethylsilane (TMS) was used as an internal standard. Liquid chromatography-mass spectrometry (LC / MS) was collected using either a SHIMADZU LCMS-2020EV or an Agilent 1260-6125B LCMS. Purity and low-resolution mass spectral data were measured using either an Agilent 1260-6125B LCMS system (equipped with a diode array detector and an Agilent G6125BA mass spectrometer) or a Waters Acquity UPLC system (equipped with a diode array detector and a Waters 3100 mass detector). Purity was characterized by UV wavelengths of 214 nm, 220 nm, 254 nm, and ESI. Column: Poloshell 120 EC-C18 2.7 μm 4.6 × 100 mm, flow rate 0.8 mL / min, solvent A (100 / 0.1 water / formic acid), solvent B (100 acetonitrile), gradient: retain 5% B up to 0.3 min, 5-95% B from 0.3 to 2 min, 95% B up to 4.8 min, 95-5% B from 4.8 to 5.4 min, then retain 5% B up to 6.5 min. Alternatively, column: Acquity UPLC BEH C18 1.7μm 2.1×50mm, flow rate 0.5mL / min, solvent A (0.1% formic acid solution), solvent B (acetonitrile), gradient: hold 5%B for 0.2 minutes, 5-95%B from 0.2 to 2.0 minutes, hold 95%B up to 3.1 minutes, then hold 5%B at 3.5 minutes. Biological assays

[0407] The biological activity of the compounds disclosed herein can be evaluated using methods and assays known in the art.

[0408] The binding ability of compounds to p300 may be determined using HTRF assay techniques. The HTRF signal may be measured by substituting the test compound with the fluorescent probe 5-(8-(7-acetyl-3-(tetrahydro-2H-pyran-4-yl)-5,6,7,8-tetrahydroimidazo[1,5-a]pyrazine-1-yl)isoquinoline-3-yl)-N-(2-(2-(2-(3-(3',6'-dihydroxy-3-oxo-3H-spiro[isobenzofuran-1,9'-xanthene]-5-yl)thioureido)ethoxy)ethoxy)ethyl)picolinamide from the FLAG-tagged p300. Data analysis is performed using IC of the test compound. 50 To determine this, appropriate software using a four-parameter dose-response curve (e.g., TIBCO Spotfire) may be used.

[0409] The binding ability of a compound to CBP may be determined using HTRF assay techniques. The HTRF signal may be measured by substituting the fluorescent probe 5-(8-(7-acetyl-3-(tetrahydro-2H-pyran-4-yl)-5,6,7,8-tetrahydroimidazo[1,5-a]pyrazine-1-yl)isoquinoline-3-yl)-N-(2-(2-(2-(3-(3',6'-dihydroxy-3-oxo-3H-spiro[isobenzofuran-1,9'-xanthene]-5-yl)thioureido)ethoxy)ethoxy)ethyl)picolinamide from the FLAG-tagged (C-terminus) and His-tagged (N-terminus) CBP constructs with the test compound. Data analysis is performed using IC of the test compound. 50 To determine this, appropriate software using a four-parameter dose-response curve (e.g., TIBCO Spotfire) may be used.

[0410] The cytolytic activity of a compound against p300 may be measured by HiBit technology in specific cells (e.g., A549 P300 HiBit cells) using the test compound at specific initial concentrations (e.g., 0.000064, 0.00019, 0.00057, 0.0017, 0.0051, 0.015, 0.046, 0.14, 0.42, and 1.25 μM) for a specific period (e.g., 2 hours). The resulting protein concentration may be evaluated using a detection buffer (e.g., HiBit Lytic detection buffer). The resulting luminescence may be measured with appropriate equipment (e.g., PerkinElmer EnVision plate reader). Dose-response curves may be generated and analyzed using appropriate software (e.g., TIBCO Spotfire) to obtain DCs of the test compound. 50 and D max You may decide that.

[0411] The cytolytic activity of a compound against CBP may be measured by HiBit technology in specific cells (e.g., A549 CBP HiBit cells) using the test compound at specific initial concentrations (e.g., 0.000064, 0.00019, 0.00057, 0.0017, 0.0051, 0.015, 0.046, 0.14, 0.42, and 1.25 μM) for a specific period (e.g., 24 hours). The resulting pr...

Claims

1. Compound of formula I: T-L-C(I), or a pharmaceutically acceptable salt, solvate, or stereoisomer thereof, in the formula, C is Equation I-1' It is, and in the formula, However, it shows adhesion to L, B １ However, CR Ｂ１ or N, B ３ However, CR Ｂ３ or N, B ４ However, CR Ｂ４ or N, B ５ However, CR Ｂ５ or N, B ６ is C or N, and R Ｂ１ , R Ｂ３ , R Ｂ４ , and R Ｂ５ However, independently, oxo, hydrogen, halogen, -CN, -NO ２ -OH, -NH ２ , C １－６ Alkyl, C １－６ Alkoxy, C １－６ Alkylamino, C ３－４ Carbocyclyl or 3-5 membered heterocyclyl, wherein the alkyl, alkoxy, alkylamino, carbocyclyl, or heterocyclyl is one or more R ｕ It may also be replaced with X does not exist, or is O, S, or NR Ｘ And, R Ｘ However, hydrogen, C １－３ Alkyl, C ３－４ Carbocyclyl, or 3-4 membered heterocyclyl, R Ｄ１ However, hydrogen, deuterium, or C １－６ It is alkyl, Each R Ｄ However, independently, oxo, halogen, -CN, -NO ２ -OH, -NH ２ , C １－６ Alkyl, C １－６ Alkoxy, C １－６ Alkylamino, C ３－４ Carbocyclyl, or 3-4 membered heterocyclyl, d is an integer between 0 and 6, as far as the valence allows, and q is an integer between 0 and 2, T, (i) Equation I-3-i (In the formula, E １ teeth, CR Ｅ１ , or N, E ２ teeth, CR Ｅ２ , or N, E ３ teeth, CR Ｅ３ , or N, However, it shows adhesion to L, R Ｅ１ 、R Ｅ２ 、R Ｅ３ 、and R Ｅ４ are, independently, hydrogen, halogen, -CN, -NO ２ 、-OH, -NH ２ 、C １－６ alkyl, C １－６ alkoxy, C １－６ alkylamino, C ２－６ alkenyl, C ２－６ alkynyl, C ３－１２ carbocyclic, 3- to 12-membered heterocyclic, C ６－１０ aryl, 5- to 10-membered heteroaryl, -SR ｂ 、-S(=O)R ａ 、-S(=O) ２ R ａ 、-S(=O) ２ OR ｂ 、-S(=O) ２ NR ｃ R ｄ 、-NR ｃ S(=O) ２ R ａ 、-NR ｃ S(=O)R ａ 、-NR ｃ S(=O) ２ OR ｂ 、-NR ｃ S(=O) ２ NR ｃ R ｄ 、-NR ｂ C(=O)NR ｃ R ｄ 、-NR ｂ C(=O)R ａ 、-NR ｂ C(=O)OR ｂ 、-OS(=O) ２ R ａ 、-OS(=O) ２ OR ｂ 、-OS(=O) ２ NR ｃ R ｄ 、-OC(=O)R ａ 、-OC(=O)OR ｂ 、-OC(=O)NR ｃ R ｄ 、-C(=O)R ａ 、-C(=O)OR ｂ , or -C(=O)NR ｃ R ｄ The alkyl, alkoxy, alkylamino, alkenyl, alkynyl, carbocykyl, heterocyclyl, aryl, or heteroaryl is one or more R ｕ It may also be replaced with F １ is C or N, F ２ NR Ｆ２’ or CR Ｆ２ And, R Ｆ２’ is hydrogen, C １－６ Alkyl, C ２－６ Alkenil, C ２－６ Alkinyl, C ３－１２ Carbocyclyl, 3-12 member heterocyclyl, C ６－１０ Aryl, 5-10 member heteroaryl, -S (=O) ２ R ａ , -S (=O) ２ OR ｂ , -S (=O) ２ NR ｃ R ｄ , -C(=O)R ａ , -C (=O) OR ｂ , or -C(=O)NR ｃ R ｄ The alkyl, alkenyl, alkynyl, carbocykyl, heterocyclyl, aryl, or heteroaryl is one or more R ｕ It may also be replaced with R Ｆ２ These are hydrogen, halogen, -CN, and -NO ２ -OH, -NH ２ , C １－６ Alkyl, C １－６ Alkoxy, C １－６ Alkylamino, C ２－６ Alkenil, C ２－６ Alkinyl, C ３－１２ Carbocyclyl, 3-12 member heterocyclyl, C ６－１０ Aryl, 5-10 member heteroaryl, -SR ｂ , -S(=O)R ａ , -S (=O) ２ R ａ , -S (=O) ２ OR ｂ , -S (=O) ２ NR ｃ R ｄ , -NR ｃ S (=O) ２ R ａ , -NR ｃ S(=O)R ａ , -NR ｃ S (=O) ２ OR ｂ , -NR ｃ S (=O) ２ NR ｃ R ｄ , -NR ｂ C(=O)NR ｃ R ｄ , -NR ｂ C(=O)R ａ , -NR ｂ C (=O) OR ｂ , -OS (=O) ２ R ａ , -OS (=O) ２ OR ｂ , -OS (=O) ２ NR ｃ R ｄ -OC(=O)R ａ , -OC(=O)OR ｂ , -OC(=O)NR ｃ R ｄ , -C(=O)R ａ , -C (=O) OR ｂ , or -C(=O)NR ｃ R ｄ The alkyl, alkoxy, alkylamino, alkenyl, alkynyl, carbocykyl, heterocyclyl, aryl, or heteroaryl is one or more R ｕ It may also be replaced with F ３ CR Ｆ３ , N, or NR Ｆ３’ And, R Ｆ３ These are hydrogen, halogen, -CN, and -NO ２ -OH, -NH ２ , C １－６ Alkyl, C １－６ Alkoxy, C １－６ Alkylamino, C ２－６ Alkenil, C ２－６ Alkinyl, C ３－１２ Carbocyclyl, 3-12 member heterocyclyl, C ６－１０ Aryl, 5-10 member heteroaryl, -SR ｂ , -S(=O)R ａ , -S (=O) ２ R ａ , -S (=O) ２ OR ｂ , -S (=O) ２ NR ｃ R ｄ , -NR ｃ S (=O) ２ R ａ , -NR ｃ S(=O)R ａ , -NR ｃ S (=O) ２ OR ｂ , -NR ｃ S (=O) ２ NR ｃ R ｄ , -NR ｂ C(=O)NR ｃ R ｄ , -NR ｂ C(=O)R ａ , -NR ｂ C (=O) OR ｂ , -OS (=O) ２ R ａ , -OS (=O) ２ OR ｂ , -OS (=O) ２ NR ｃ R ｄ -OC(=O)R ａ , -OC(=O)OR ｂ , -OC(=O)NR ｃ R ｄ , -C(=O)R ａ , -C (=O) OR ｂ , or -C(=O)NR ｃ R ｄ The alkyl, alkoxy, alkylamino, alkenyl, alkynyl, carbocykyl, heterocyclyl, aryl, or heteroaryl is one or more R ｕ It may also be replaced with R Ｆ３’ However, hydrogen, C １－６ Alkyl, C ２－６ Alkenil, C ２－６ Alkinyl, C ３－１２ Carbocyclyl, 3-12 member heterocyclyl, C ６－１０ Aryl, 5-10 member heteroaryl, -S (=O) ２ R ａ , -S (=O) ２ OR ｂ , -S (=O) ２ NR ｃ R ｄ , -C(=O)R ａ , -C (=O) OR ｂ , or -C(=O)NR ｃ R ｄ The alkyl, alkenyl, alkynyl, carbocykyl, heterocyclyl, aryl, or heteroaryl is one or more R ｕ It may also be replaced with R Ｆ４ is -C(=O)NR ３ａ R ３ｂ , or one or more R ｕ A 5-6 member heteroaryl which may be substituted with, R ３ａ and R ３ｂ These are, independently, hydrogen, C １－６ Alkyl, C ２－６ Alkenil, C ２－６ Alkinyl, C ３－１２ Carbocyclyl, 3-12 member heterocyclyl, C ６－１０ Aryl, 5-10 member heteroaryl, -S (=O) ２ R ａ , -S (=O) ２ OR ｂ , -S (=O) ２ NR ｃ R ｄ , -C(=O)R ａ , -C (=O) OR ｂ , or -C(=O)NR ｃ R ｄ The alkyl, alkenyl, alkynyl, carbocykyl, heterocyclyl, aryl, or heteroaryl is one or more R ｕ Is it okay if it is replaced with, or R ３ａ and R ３ｂ These, together with the nitrogen atoms to which they are bonded, form a 3- to 12-membered heterocycle or a 5- to 10-membered heteroaryl, and the heterocycle or heteroaryl has one or more R ｕ (May be replaced with) Is it theirs? (ii) Formula I-3-ii (In the formula, G １ teeth, , N, or CR Ｇ１ And, G ２ teeth, , N, or CR Ｇ２ And, G ３ teeth, , N, or CR Ｇ３ And, This indicates adhesion to L. R Ｇ１ , R Ｇ２ , R Ｇ３ , and R Ｇ４ These are independently hydrogen, halogen, -CN, and -NO ２ -OH, -NH ２ , C １－６ Alkyl, C １－６ Alkoxy, C １－６ Alkylamino, C ２－６ Alkenil, C ２－６ Alkinyl, C ３－１２ Carbocyclyl, 3-12 member heterocyclyl, C ６－１０ Aryl, 5-10 member heteroaryl, -SR ｂ , -S(=O)R ａ , -S (=O) ２ R ａ , -S (=O) ２ OR ｂ , -S (=O) ２ NR ｃ R ｄ , -NR ｃ S (=O) ２ R ａ , -NR ｃ S(=O)R ａ , -NR ｃ S (=O) ２ OR ｂ , -NR ｃ S (=O) ２ NR ｃ R ｄ , -NR ｂ C(=O)NR ｃ R ｄ , -NR ｂ C(=O)R ａ , -NR ｂ C (=O) OR ｂ , -OS (=O) ２ R ａ , -OS (=O) ２ OR ｂ , -OS (=O) ２ NR ｃ R ｄ -OC(=O)R ａ , -OC(=O)OR ｂ , -OC(=O)NR ｃ R ｄ , -C(=O)R ａ , -C (=O) OR ｂ , or -C(=O)NR ｃ R ｄ The alkyl, alkoxy, alkylamino, alkenyl, alkynyl, carbocykyl, heterocyclyl, aryl, or heteroaryl is one or more R ｕ It may also be replaced with H １ is C(R Ｈ１ ) ２ , NR Ｈ１’ , or O, H ２ is C(R Ｈ２ ) ２ , NR Ｈ２’ , or O, R Ｈ１ and R Ｈ２ Each occurrence is independently of hydrogen, halogen, -CN, and -NO. ２ -OH, -NH ２ , C １－６ Alkyl, C １－６ Alkoxy, C １－６ Alkylamino, C ２－６ Alkenil, C ２－６ Alkinyl, C ３－１２ Carbocyclyl, 3-12 member heterocyclyl, C ６－１０ The alkyl, alkoxy, alkylamino, alkenyl, alkynyl, carbocykrill, heterocyclyl, aryl, or heteroaryl is one or more R ｕ Is it okay if it is replaced with, or Two R's Ｈ１ or two R's Ｈ２ Together with the carbon atoms to which they are bonded, C ３－６ It forms a carbon ring or a 3- to 6-membered heterocycle, and the carbon ring or heterocycle has one or more R ｕ It may be replaced with, and R Ｈ１’ and R Ｈ２’ These are independently hydrogen and C １－６ Alkyl, C ３－６ Carbocyclyl, 3-6 member heterocyclyl, -S (=O) ２ R ａ , -S (=O) ２ OR ｂ , -S (=O) ２ NR ｃ R ｄ , -C(=O)R ａ , -C (=O) OR ｂ , or -C(=O)NR ｃ R ｄ The alkyl, carbocyacrylic, or heterocyclyl is one or more R ｕ (May be replaced with) Is it theirs? (iii) Formula I-3-iii (In the formula, This indicates adhesion to L. I １ is C(R Ｉ１ ) ２ , NR Ｉ１’ , or O, I ２ is C(R Ｉ２ ) ２ , NR Ｉ２’ , or O, R Ｉ１ and R Ｉ２ Each occurrence is independently of hydrogen, halogen, -CN, and -NO. ２ -OH, -NH ２ , C １－６ Alkyl, C １－６ Alkoxy, C １－６ Alkylamino, C ２－６ Alkenil, C ２－６ Alkinyl, C ３－１２ Carbocyclyl, 3-12 member heterocyclyl, C ６－１０ The alkyl, alkoxy, alkylamino, alkenyl, alkynyl, carbocykrill, heterocyclyl, aryl, or heteroaryl is one or more R ｕ Is it okay if it is replaced with, or Two R's Ｉ１ or two R's Ｉ２ Together with the carbon atoms to which they are bonded, C ３－６ It forms a carbon ring or a 3- to 6-membered heterocycle, and the carbon ring or heterocycle has one or more R ｕ It may also be replaced with R Ｉ１’ and R Ｉ２’ These are independently hydrogen and C １－６ Alkyl, C ３－６ Carbocyclyl, 3-6 member heterocyclyl, -S (=O) ２ R ａ , -S (=O) ２ OR ｂ , -S (=O) ２ NR ｃ R ｄ , -C(=O)R ａ , -C (=O) OR ｂ , or -C(=O)NR ｃ R ｄ The alkyl, carbocyacrylic, or heterocyclyl is one or more R ｕ It may also be replaced with Each R Ｉ These are independently oxo, halogen, -CN, and -NO ２ -OH, -NH ２ , C １－６ Alkyl, C １－６ Alkoxy, C １－６ Alkylamino, C ２－６ Alkenil, C ２－６ Alkinyl, C ３－１２ Carbocyclyl, 3-12 member heterocyclyl, C ６－１０ Aryl, 5-10 member heteroaryl, -SR ｂ , -S(=O)R ａ , -S (=O) ２ R ａ , -S (=O) ２ OR ｂ , -S (=O) ２ NR ｃ R ｄ , -NR ｃ S (=O) ２ R ａ , -NR ｃ S(=O)R ａ , -NR ｃ S (=O) ２ OR ｂ , -NR ｃ S (=O) ２ NR ｃ R ｄ , -NR ｂ C(=O)NR ｃ R ｄ , -NR ｂ C(=O)R ａ , -NR ｂ C (=O) OR ｂ , -OS (=O) ２ R ａ , -OS (=O) ２ OR ｂ , -OS (=O) ２ NR ｃ R ｄ -OC(=O)R ａ , -OC(=O)OR ｂ , -OC(=O)NR ｃ R ｄ , -C(=O)R ａ , -C (=O) OR ｂ , or -C(=O)NR ｃ R ｄ The alkyl, alkoxy, alkylamino, alkenyl, alkynyl, carbocykyl, heterocyclyl, aryl, or heteroaryl is one or more R ｕ It may also be replaced with i is an integer selected from 0 to 4. J １ is N or CR Ｊ１ And, J ２ is N or CR Ｊ２ and R Ｊ１ , R Ｊ２ , and R Ｊ３ These are independently hydrogen, halogen, -CN, and -NO ２ -OH, -NH ２ , C １－６ Alkyl, C １－６ Alkoxy, C １－６ Alkylamino, C ２－６ Alkenil, C ２－６ Alkinyl, C ３－１２ Carbocyclyl, 3-12 member heterocyclyl, C ６－１０ Aryl, 5-10 member heteroaryl, -SR ｂ , -S(=O)R ａ , -S (=O) ２ R ａ , -S (=O) ２ OR ｂ , -S (=O) ２ NR ｃ R ｄ , -NR ｃ S (=O) ２ R ａ , -NR ｃ S(=O)R ａ , -NR ｃ S (=O) ２ OR ｂ , -NR ｃ S (=O) ２ NR ｃ R ｄ , -NR ｂ C(=O)NR ｃ R ｄ , -NR ｂ C(=O)R ａ , -NR ｂ C (=O) OR ｂ , -OS (=O) ２ R ａ , -OS (=O) ２ OR ｂ , -OS (=O) ２ NR ｃ R ｄ -OC(=O)R ａ , -OC(=O)OR ｂ , -OC(=O)NR ｃ R ｄ , -C(=O)R ａ , -C (=O) OR ｂ , or -C(=O)NR ｃ R ｄ The alkyl, alkoxy, alkylamino, alkenyl, alkynyl, carbocykyl, heterocyclyl, aryl, or heteroaryl is one or more R ｕ (May be replaced with) Is it theirs? (iv) Formula I-3-iv (In the formula, M １ is N or C, M ２ teeth, , N, or CR Ｍ２ And, M ３ teeth, , N, or CR Ｍ３ And, M ４ teeth, , N, or CR Ｍ４ And, This indicates adhesion to L, and M １ M ２ M ３ , and M ４ At least one of them is N or And, R Ｍ２ , R Ｍ３ , and R Ｍ４ These are independently hydrogen, halogen, -CN, and -NO ２ -OH, -NH ２ , C １－６ Alkyl, C １－６ Alkoxy, C １－６ Alkylamino, C ２－６ Alkenil, C ２－６ Alkinyl, C ３－１２ Carbocyclyl, 3-12 member heterocyclyl, C ６－１０ Aryl, 5-10 member heteroaryl, -SR ｂ , -S(=O)R ａ , -S (=O) ２ R ａ , -S (=O) ２ OR ｂ , -S (=O) ２ NR ｃ R ｄ , -NR ｃ S (=O) ２ R ａ , -NR ｃ S(=O)R ａ , -NR ｃ S (=O) ２ OR ｂ , -NR ｃ S (=O) ２ NR ｃ R ｄ , -NR ｂ C(=O)NR ｃ R ｄ , -NR ｂ C(=O)R ａ , -NR ｂ C (=O) OR ｂ , -OS (=O) ２ R ａ , -OS (=O) ２ OR ｂ , -OS (=O) ２ NR ｃ R ｄ -OC(=O)R ａ , -OC(=O)OR ｂ , -OC(=O)NR ｃ R ｄ , -C(=O)R ａ , -C (=O) OR ｂ , or -C(=O)NR ｃ R ｄ The alkyl, alkoxy, alkylamino, alkenyl, alkynyl, carbocykyl, heterocyclyl, aryl, or heteroaryl is one or more R ｕ It may also be replaced with R Ｋ’ is hydrogen, C １－６ Alkyl, C ２－６ Alkenil, C ２－６ Alkinyl, C ３－１２ Carbocyclyl, 3-12 member heterocyclyl, C ６－１０ Aryl, 5-10 member heteroaryl, -S (=O) ２ R ａ , -S (=O) ２ OR ｂ , -S (=O) ２ NR ｃ R ｄ , -C(=O)R ａ , -C (=O) OR ｂ , or -C(=O)NR ｃ R ｄ The alkyl, alkenyl, alkynyl, carbocykyl, heterocyclyl, aryl, or heteroaryl is one or more R ｕ It may also be replaced with K １ is -C(=O)- or -C(R Ｋ１ ) ２ - and Each R Ｋ１ These are independently hydrogen, halogen, -CN, and -NO ２ -OH, -NH ２ , C １－６ Alkyl, C １－６ Alkoxy, C １－６ Alkylamino, C ２－６ Alkenil, C ２－６ Alkinyl, C ３－１２ Carbocyclyl, 3-12 member heterocyclyl, C ６－１０ The alkyl, alkoxy, alkylamino, alkenyl, alkynyl, carbocykrill, heterocyclyl, aryl, or heteroaryl is one or more R ｕ It may also be replaced with Each R Ｋ These are independently oxo, hydrogen, halogen, -CN, and -NO ２ -OH, -NH ２ , C １－６ Alkyl, C １－６ Alkoxy, C １－６ Alkylamino, C ２－６ Alkenil, C ２－６ Alkinyl, C ３－１２ Carbocyclyl, 3-12 member heterocyclyl, C ６－１０ Aryl, 5-10 member heteroaryl, -SR ｂ , -S(=O)R ａ , -S (=O) ２ R ａ , -S (=O) ２ OR ｂ , -S (=O) ２ NR ｃ R ｄ , -NR ｃ S (=O) ２ R ａ , -NR ｃ S(=O)R ａ , -NR ｃ S (=O) ２ OR ｂ , -NR ｃ S (=O) ２ NR ｃ R ｄ , -NR ｂ C(=O)NR ｃ R ｄ , -NR ｂ C(=O)R ａ , -NR ｂ C (=O) OR ｂ , -OS (=O) ２ R ａ , -OS (=O) ２ OR ｂ , -OS (=O) ２ NR ｃ R ｄ -OC(=O)R ａ , -OC(=O)OR ｂ , -OC(=O)NR ｃ R ｄ , -C(=O)R ａ , -C (=O) OR ｂ , or -C(=O)NR ｃ R ｄ The alkyl, alkoxy, alkylamino, alkenyl, alkynyl, carbocykyl, heterocyclyl, aryl, or heteroaryl is one or more R ｕ It may be replaced with, and k is an integer selected from 0 to 4. Is it theirs? (v) Equation I-3-v (In the formula, P １ teeth, , N, or CR Ｐ１ And, P ２ teeth, , N, or CR Ｐ２ And, This indicates adhesion to L. Each R Ｎ These are independently oxo, halogen, -CN, and -NO ２ -OH, -NH ２ , C １－６ Alkyl, C １－６ Alkoxy, C １－６ Alkylamino, C ２－６ Alkenil, C ２－６ Alkinyl, C ３－１２ Carbocyclyl, 3-12 member heterocyclyl, C ６－１０ Aryl, 5-10 member heteroaryl, -SR ｂ , -S(=O)R ａ , -S (=O) ２ R ａ , -S (=O) ２ OR ｂ , -S (=O) ２ NR ｃ R ｄ , -NR ｃ S (=O) ２ R ａ , -NR ｃ S(=O)R ａ , -NR ｃ S (=O) ２ OR ｂ , -NR ｃ S (=O) ２ NR ｃ R ｄ , -NR ｂ C(=O)NR ｃ R ｄ , -NR ｂ C(=O)R ａ , -NR ｂ C (=O) OR ｂ , -OS (=O) ２ R ａ , -OS (=O) ２ OR ｂ , -OS (=O) ２ NR ｃ R ｄ -OC(=O)R ａ , -OC(=O)OR ｂ , -OC(=O)NR ｃ R ｄ , -C(=O)R ａ , -C (=O) OR ｂ , or -C(=O)NR ｃ R ｄ The alkyl, alkoxy, alkylamino, alkenyl, alkynyl, carbocykyl, heterocyclyl, aryl, or heteroaryl is one or more R ｕ It may also be replaced with n is an integer selected from 0 to 6. R Ｐ１ , R Ｐ２ , and R Ｐ３ These are independently hydrogen, halogen, -CN, and -NO ２ -OH, -NH ２ , C １－６ Alkyl, C １－６ Alkoxy, C １－６ Alkylamino, C ２－６ Alkenil, C ２－６ Alkinyl, C ３－１２ Carbocyclyl, 3-12 member heterocyclyl, C ６－１０ Aryl, 5-10 member heteroaryl, -SR ｂ , -S(=O)R ａ , -S (=O) ２ R ａ , -S (=O) ２ OR ｂ , -S (=O) ２ NR ｃ R ｄ , -NR ｃ S (=O) ２ R ａ , -NR ｃ S(=O)R ａ , -NR ｃ S (=O) ２ OR ｂ , -NR ｃ S (=O) ２ NR ｃ R ｄ , -NR ｂ C(=O)NR ｃ R ｄ , -NR ｂ C(=O)R ａ , -NR ｂ C (=O) OR ｂ , -OS (=O) ２ R ａ , -OS (=O) ２ OR ｂ , -OS (=O) ２ NR ｃ R ｄ -OC(=O)R ａ , -OC(=O)OR ｂ , -OC(=O)NR ｃ R ｄ , -C(=O)R ａ , -C (=O) OR ｂ , or -C(=O)NR ｃ R ｄ The alkyl, alkoxy, alkylamino, alkenyl, alkynyl, carbocykyl, heterocyclyl, aryl, or heteroaryl is one or more R ｕ It may be replaced with, and R ４ is -OH, -NH ２ , C １－６ Alkyl, C １－６ Alkoxy, C １－６ Alkylamino, C ２－６ Alkenil, C ２－６ Alkinyl, C ３－１２ Carbocyclyl, 3-12 member heterocyclyl, C ６－１０ The alkyl, alkoxy, alkylamino, alkenyl, alkynyl, carbocykrill, heterocyclyl, aryl, or heteroaryl is one or more R ｕ (May be replaced with) It is or (vi) Formula I-3-vi (In the formula, Q １ NR Ｑ１’ , C(R Ｑ１ ) ２ , or O, R Ｑ１’ is hydrogen, C １－６ Alkyl, C ２－６ Alkenil, C ２－６ Alkinyl, C ３－１２ Carbocyclyl, 3-12 member heterocyclyl, C ６－１０ Aryl, 5-10 member heteroaryl, -S (=O) ２ R ａ , -S (=O) ２ OR ｂ , -S (=O) ２ NR ｃ R ｄ , -C(=O)R ａ , -C (=O) OR ｂ , or -C(=O)NR ｃ R ｄ The alkyl, alkenyl, alkynyl, carbocykyl, heterocyclyl, aryl, or heteroaryl is one or more R ｕ It may also be replaced with Each R Ｑ１ These are independently hydrogen, halogen, -CN, and -NO ２ -OH, -NH ２ , C １－６ Alkyl, C １－６ Alkoxy, C １－６ Alkylamino, C ２－６ Alkenil, C ２－６ Alkinyl, C ３－１２ Carbocyclyl, 3-12 member heterocyclyl, C ６－１０ The alkyl, alkoxy, alkylamino, alkenyl, alkynyl, carbocykrill, heterocyclyl, aryl, or heteroaryl is one or more R ｕ Is it okay if it is replaced with, or Two R's Ｑ１ Together with the carbon atoms to which they are bonded, C ３－６ It forms a carbon ring or a 3- to 6-membered heterocycle, and the carbon ring or heterocycle has one or more R ｕ It may also be replaced with If it is a double bond, Q ２ is N or CR Ｑ２ Q ３ is N or CR Ｑ３ And, If it is a single bond, Q ２ NR Ｑ２’ , C(R Ｑ２ ) ２ , or O, Q ３ NR Ｑ３’ , C(R Ｑ３ ) ２ , or O, R Ｑ２’ and R Ｑ３’ These are, independently, hydrogen, C １－６ Alkyl, C ２－６ Alkenil, C ２－６ Alkinyl, C ３－１２ Carbocyclyl, 3-12 member heterocyclyl, C ６－１０ Aryl, 5-10 member heteroaryl, -S (=O) ２ R ａ , -S (=O) ２ OR ｂ , -S (=O) ２ NR ｃ R ｄ , -C(=O)R ａ , -C (=O) OR ｂ , or -C(=O)NR ｃ R ｄ The alkyl, alkenyl, alkynyl, carbocykyl, heterocyclyl, aryl, or heteroaryl is one or more R ｕ It may also be replaced with R Ｑ２ and R Ｑ３ Each occurrence is independently of hydrogen, halogen, -CN, and -NO. ２ -OH, -NH ２ , C １－６ Alkyl, C １－６ Alkoxy, C １－６ Alkylamino, C ２－６ Alkenil, C ２－６ Alkinyl, C ３－１２ Carbocyclyl, 3-12 member heterocyclyl, C ６－１０ The alkyl, alkoxy, alkylamino, alkenyl, alkynyl, carbocykrill, heterocyclyl, aryl, or heteroaryl is one or more R ｕ Is it okay if it is replaced with, or Two R's Ｑ２ or two R's Ｑ３ Together with the carbon atoms to which they are bonded, C ３－６ It forms a carbon ring or a 3- to 6-membered heterocycle, and the carbon ring or heterocycle has one or more R ｕ It may also be replaced with S １ CR Ｓ１ or N, S ２ teeth, CR Ｓ２ , or N, S ３ teeth, CR Ｓ３ , or N, S ４ teeth, CR Ｓ４ , or N, This indicates adhesion to L, and R Ｓ１ 、R Ｓ２ 、R Ｓ３ 、and R Ｓ４ are, independently, hydrogen, halogen, -CN, -NO ２ 、-OH, -NH ２ 、C １－６ alkyl, C １－６ alkoxy, C １－６ alkylamino, C ２－６ alkenyl, C ２－６ alkynyl, C ３－１２ carbocyclic, 3- to 12-membered heterocyclic, C ６－１０ aryl, 5- to 10-membered heteroaryl, -SR ｂ 、-S(=O)R ａ 、-S(=O) ２ R ａ 、-S(=O) ２ OR ｂ 、-S(=O) ２ NR ｃ R ｄ 、-NR ｃ S(=O) ２ R ａ 、-NR ｃ S(=O)R ａ 、-NR ｃ S(=O) ２ OR ｂ 、-NR ｃ S(=O) ２ NR ｃ R ｄ 、-NR ｂ C(=O)NR ｃ R ｄ 、-NR ｂ C(=O)R ａ 、-NR ｂ C(=O)OR ｂ 、-OS(=O) ２ R ａ 、-OS(=O) ２ OR ｂ 、-OS(=O) ２ NR ｃ R ｄ 、-OC(=O)R ａ 、-OC(=O)OR ｂ 、-OC(=O)NR ｃ R ｄ 、-C(=O)R ａ 、-C(=O)OR ｂ , or -C(=O)NR ｃ R ｄ The alkyl, alkoxy, alkylamino, alkenyl, alkynyl, carbocykyl, heterocyclyl, aryl, or heteroaryl is one or more R ｕ (May be replaced with) It is, L is given by Equation I-2'' It is, and in the formula, However, it shows adhesion to C, Cy １ but, And in the formula, However, it shows adhesion to T, T １ However, CR Ｔ１ or N, V １ However, CR Ｖ１ or N, V ２ However, CR Ｖ２ or N, R Ｔ１ 、 R Ｖ１ 、 and R Ｖ２ are each independently hydrogen, halogen, -CN, -NO ２ , -OH, -NH ２ , C １－６ alkyl, C １－６ alkoxy, C １－６ alkylamino, C ３－４ carbocyclic, or 3- to 4-membered heterocyclic, and Each R Ｔ However, independently, halogen, -CN, -NO ２ -OH, -NH ２ , C １－６ Alkyl, C １－６ Alkoxy, C １－６ Alkylamino, C ３－４ Carbocyclyl, or 3-4 membered heterocyclyl, t is an integer selected from 0 to 6, as long as the valence allows. or Cy １ but, And in the formula, If it is a double bond, Y １ is C, If it is a single bond, Y １ is N or CR Ｙ１ And, However, it shows adhesion to T, R Ｙ１ However, hydrogen, halogens, -CN, -NO ２ -OH, -NH ２ , C １－６ Alkyl, C １－６ Alkoxy, C １－６ Alkylamino, C ３－４ Carbocyclyl, or 3-4 membered heterocyclyl, Y ２ However, C(R Ｙ２ ) ２ , O, or N(R Ｙ２’ ) and Each R Ｙ２ However, independently, hydrogen, halogen, -CN, -NO ２ -OH, -NH ２ , C １－６ Alkyl, C １－６ Alkoxy, C １－６ Alkylamino, C ３－４ Carbocyclyl, or 3-4 membered heterocyclyl, R Ｙ２’ However, hydrogen, C １－６ Alkyl, C ３－４ Carbocyclyl, 3-4 member heterocyclyl, -S (=O) ２ R ａ , -S (=O) ２ OR ｂ , -S (=O) ２ NR ｃ R ｄ , -C(=O)R ａ , -C (=O) OR ｂ , or -C(=O)NR ｃ R ｄ And, Z １ However, CR Ｚ１ or N, Z ２ However, CR Ｚ２ or N, R Ｚ１ and R Ｚ２ These independently produce hydrogen, halogen, -CN, and -NO. ２ -OH, -NH ２ , C １－６ Alkyl, C １－６ Haloalkyl, C １－６ Alkoxy, C １－６ Alkylamino, C ３－４ Carbocyclyl, or 3-4 membered heterocyclyl, Each R Ｚ However, independently, oxo, halogen, -CN, -NO ２ -OH, -NH ２ , C １－６ Alkyl, C １－６ Alkoxy, C １－６ Alkylamino, C ３－４ Carbocyclyl, or 3-4 membered heterocyclyl, z is an integer selected from 0 to 6, as long as the valence allows. Here, R Ｚ However, it may exist in either ring Y or ring Z. Cy ２ However, C ６ Arylene or 5-6 member heteroarylene, wherein the arylene or heteroarylene contains one or more R ｕ It may also be replaced with L ２ However, CH ２ or CH(C １－３ It is alkyl, and L ３ However, E-ethenylene, ethinylene, C ６ Arylene, or 5-6 member heteroarylene, wherein the E-ethenylene, arylene, or heteroarylene contains one or more R ｕ It may also be replaced with Here, Each R ｕ However, independently, oxo, halogen, -CN, -NO ２ -OH, -NH ２ , C １－６ Alkyl, C １－６ Alkoxy, C １－６ Alkylamino 、 C ３－４ Carbocyclyl, or 3-6 membered heterocyclyl, Each R ａ However, independently, C １－６ Alkyl, C ３－６ Carbocyclyl, or 3-6 membered heterocyclyl, Each R ｂ However, independently, hydrogen, C １－６ Alkyl, C ３－６ It is a carbocyclyl, or a 3- to 6-membered heterocyclyl, and R ｃ and R ｄ Each of them independently produces hydrogen and C １－６ Alkyl, C ３－６ It is either a carbocyclyl or a 3- to 6-membered heterocyclyl, or R ｃ and R ｄ However, together with the nitrogen atoms to which they are bonded, they form 3-6 membered heterocyclines. R ａ , R ｂ , R ｃ , and R ｄ Each occurrence of independently determines one or more R ｚ It may be replaced with, and Each R ｚ However, independently, oxo, halogen, -CN, -NO ２ -OH, -NH ２ , C １－６ Alkyl, C １－６ Alkoxy, C １－６ Alkylamino, C ３－６ Carbocyclyl, or 3-6 membered heterocyclyl, However, the compound of formula I is but But not, The aforementioned compound, or a pharmaceutically acceptable salt, solvate, or stereoisomer thereof.

2. C is the expression I-1-i, I-1-ii, or I-1-iii The compound according to claim 1, wherein the compound is as described above.

3. B １ , B ３ , B ４ , and B ５ None of the above are N, or B １ and B ５ The compound according to claim 2, wherein one of the atoms is N.

4. C is one of the following: I-1-i-1', I-1-i-2', I-1-i-3, I-1-ii-1, I-1-ii-2, I-1-ii-3, I-1-iiii-1, I-1-iiii-2, or I-1-iiii-3 The compound according to claim 3, wherein the compound is as described above.

5. R Ｂ１ , R Ｂ３ , R Ｂ４ , and R Ｂ５ , R Ｂ１ , R Ｂ３ , and R Ｂ４ ,or R Ｂ３ , R Ｂ４ , and R Ｂ５ These independently form oxo, hydrogen, halogen, -CN, -OH, and C. １－６ Alkyl, C １－６ Haloalkyl, C １－６ Alkoxy, or C １－６ A compound according to any one of claims 2 to 4, wherein it is an alkylamino compound.

6. R Ｂ１ , R Ｂ３ , R Ｂ４ , and R Ｂ５ , R Ｂ１ , R Ｂ３ , and R Ｂ４ ,or R Ｂ３ , R Ｂ４ , and R Ｂ５ These independently produce hydrogen, halogen, or C １－６ The compound according to claim 5, wherein it is alkyl.

7. T is given by equation I-3-ii The compound according to any one of claims 1 to 6.

8. T is given by equation I-3-ii-a The compound according to claim 7, wherein the compound is as described above.

9. G １ CR Ｇ１ G ３ is N or CR Ｇ３ And R Ｇ１ and R Ｇ３ However, independently, hydrogen, halogen, -CN, -NO ２ -OH, -NH ２ , C １－６ Alkyl, C １－６ Alkoxy, C １－６ Alkylamino, C ２－６ Alkenil, C ２－６ Alkinyl, C ３－１２ Carbocyclyl, 3-12 member heterocyclyl, C ６－１０ The alkyl, alkoxy, alkylamino, alkenyl, alkynyl, carbocykrill, heterocyclyl, aryl, or heteroaryl is one or more R ｕ The compound according to claim 6 or 7, which may be substituted with

10. R Ｇ１ and R Ｇ３ The compound according to claim 9, wherein each of them is hydrogen.

11. R Ｇ４ However, hydrogen, halogens, -CN, -NO ２ -OH, -NH ２ , C １－６ Alkyl, C １－６ Alkoxy, C １－６ Alkylamino, C ２－６ Alkenil, C ２－６ Alkinyl, C ３－１２ Carbocyclyl, 3-12 member heterocyclyl, C ６－１０ The alkyl, alkoxy, alkylamino, alkenyl, alkynyl, carbocykrill, heterocyclyl, aryl, or heteroaryl is one or more R ｕ The compound according to any one of claims 7 to 10, which may be substituted with

12. R Ｇ４ However, hydrogen, C １－６ Alkyl, C １－６ Alkoxy, C １－６ Alkylamino, C ２－６ Alkenyl or 3-12 membered heterocyclyl, wherein the alkyl, alkoxy, alkylamino, alkenyl, or heterocyclyl is one or more R ｕ The compound according to claim 11, which may be substituted with

13. H １ NR Ｈ１’ H ２ NR Ｈ２’ And R Ｈ１’ and R Ｈ２’ Independently, hydrogen or C １－６ The compound according to any one of claims 7 to 12, wherein it is alkyl.

14. T is given by equation I-3-iv The compound according to any one of claims 1 to 6.

15. T is given by equation I-3-iv-a The compound according to claim 14, wherein the compound is as described above.

16. K １ The compound according to claim 14 or 15, wherein the compound is -C(=O)-.

17. M １ M ３ , and M ４ The compound according to any one of claims 14 to 16, wherein at least two of the elements are N.

18. M １ M ３ , and M ４ The compound according to any one of claims 14 to 17, wherein at least one of the elements is N.

19. M ３ The compound according to any one of claims 14 to 18, wherein N is present.

20. M ３ However, CR Ｍ３ And R Ｍ３ However, hydrogen, halogens, -CN, -NO ２ -OH, -NH ２ , C １－６ Alkyl, C １－６ Alkoxy, C １－６ Alkylamino, C ２－６ Alkenil, C ２－６ Alkinyl, C ３－１２ Carbocyclyl, 3-12 member heterocyclyl, C ６－１０ The alkyl, alkoxy, alkylamino, alkenyl, alkynyl, carbocykrill, heterocyclyl, aryl, or heteroaryl is one or more R ｕ The compound according to any one of claims 14 to 18, which may be substituted with

21. T is given by equation I-3-iv-b The compound according to claim 14, wherein the compound is as described above.

22. Each R Ｋ Independently, hydrogen or C １－６ The compound according to any one of claims 14 to 21, wherein it is alkyl.

23. R Ｋ’ However, hydrogen or C １－６ The compound according to any one of claims 14 to 22, wherein it is alkyl.

24. R Ｍ２ However, hydrogen, halogens, -CN, -NO ２ -OH, -NH ２ , C １－６ Alkyl, C １－６ Alkoxy, C １－６ Alkylamino, C ２－６ Alkenil, C ２－６ Alkinyl, C ３－１２ Carbocyclyl, 3-12 member heterocyclyl, C ６－１０ The alkyl, alkoxy, alkylamino, alkenyl, alkynyl, carbocykrill, heterocyclyl, aryl, or heteroaryl is one or more R ｕ The compound according to any one of claims 14 to 23, which may be substituted with

25. T is of formula I-3-vi The compound according to any one of claims 1 to 6.

26. T is expressed in formula I-3-vi-a or I-3-vi-b The compound according to claim 25, wherein the compound is as described above.

27. R Ｓ２ However, hydrogen, halogens, -CN, -NO ２ -OH, -NH ２ , C １－６ Alkyl, C １－６ Alkoxy, C １－６ Alkylamino, C ２－６ Alkenil, C ２－６ Alkinyl, C ３－１２ Carbocyclyl, 3-12 member heterocyclyl, C ６－１０ The alkyl or 5-10 membered heteroaryl is one or more R ｕ The compound according to claim 25 or 26, which may be substituted with

28. R Ｓ４ However, hydrogen, halogens, -CN, -NO ２ -OH, -NH ２ , C １－６ Alkyl, C １－６ Alkoxy, C １－６ Alkylamino, C ２－６ Alkenil, C ２－６ Alkinyl, C ３－１２ Carbocyclyl, 3-12 member heterocyclyl, C ６－１０ The alkyl, alkoxy, alkylamino, alkenyl, alkynyl, carbocykrill, heterocyclyl, aryl, or heteroaryl is one or more R ｕ The compound according to any one of claims 25 to 27, which may be substituted with

29. Q １ However, NR Ｑ１’ And R Ｑ１’ However, hydrogen or C １－６ The compound according to any one of claims 25 to 28, wherein it is alkyl.

30. is a double bond, Q ２ is N or CR Ｑ２ Q ３ CR Ｑ３ And, R Ｑ２ and R Ｑ３ These independently produce hydrogen, halogen, -CN, and -NO. ２ -OH, -NH ２ , C １－６ Alkyl, C １－６ Alkoxy, C １－６ Alkylamino, C ３－４ It is a carbocyclyl, or a 3-4 member heterocyclyl. The compound according to any one of claims 25 to 29.

31. R Ｑ２ and R Ｑ３ Independently, hydrogen or C １－６ The compound according to claim 30, wherein it is alkyl. Claim 32 is a single bond, and in this case Q ２ is C(R Ｑ２ ) ２ Q ３ NR Ｑ３’ or C(R) Ｑ３ ) ２ And, R Ｑ２ and R Ｑ３ Each of these independently produces hydrogen, halogen, -CN, and -NO. ２ -OH, -NH ２ , C １－６ Alkyl, C １－６ Alkoxy, C １－６ Alkylamino, C ３－４ Carbocyclyl, or a 3-4 membered heterocyclyl, and R Ｑ３’ However, hydrogen, C １－６ Alkyl, C ３－４ It is a carbocyclyl, or a 3-4 member heterocyclyl. The compound according to any one of claims 25 to 31.

33. Each R Ｑ２ However, hydrogen or C １－６ It is alkyl, R Ｑ３’ However, C １－６ It is alkyl, R Ｑ２ and R Ｑ３ Each of them independently, hydrogen or C １－６ The compound according to claim 32, wherein it is alkyl.

34. S １ CR Ｓ１ and S ３ CR Ｓ３ And, R Ｓ１ and R Ｓ３ These independently produce hydrogen, halogen, -CN, and -NO. ２ -OH, -NH ２ , C １－６ Alkyl, C １－６ Alkoxy, C １－６ Alkylamino, C ２－６ Alkenil, C ２－６ Alkinyl, C ３－１２ Carbocyclyl, 3-12 member heterocyclyl, C ６－１０ The alkyl, alkoxy, alkylamino, alkenyl, alkynyl, carbocykrill, heterocyclyl, aryl, or heteroaryl is one or more R ｕ It may be replaced with The compound according to any one of claims 25 to 33.

35. Cy １ but, The compound according to any one of claims 1 to 34.

36. V １ The compound according to claim 35, wherein N is present.

37. T １ CR Ｔ１ V ２ CR Ｖ２ And R Ｔ１ and R Ｖ２ The compound according to claim 35 or 36, wherein is hydrogen.

38. Cy １ but, The compound according to claim 37.

39. Cy １ but, The compound according to any one of claims 1 to 38.

40. Cy １ but, The compound according to claim 39.

41. Cy ２ However, one or more halogens, C １－６ Alkyl, or C １－６ A pyridinylene which may be substituted with an alkoxy, and the C １－６ Alkoxy is one or more C １－６ The compound according to any one of claims 1 to 40, which may be substituted with an alkoxy.

42. Cy ２ but, And, In the formula, ## is Cy １ The compound according to claim 41, which exhibits adhesion to a surface.

43. L ２ However, CH ２ The compound according to any one of claims 1 to 42.

44. L ３ The compound according to any one of claims 1 to 43, wherein the compound is E-ethenylene, ethynylene, or 1,4-phenylene.

45. Compounds selected from the compounds listed in Tables 1-3, or pharmaceutically acceptable salts thereof.

46. A pharmaceutical composition comprising a compound according to any one of claims 1 to 45 and a pharmaceutically acceptable excipient.

47. A method for degrading a protein in a target or biological sample, comprising administering a compound according to any one of claims 1 to 45 to the target, or contacting the biological sample with a compound according to any one of claims 1 to 45.

48. Use of a compound according to any one of claims 1 to 45 in the manufacture of a pharmaceutical product for degrading proteins in a target or biological sample.

49. A compound according to any one of claims 1 to 45, for use in the degradation of proteins in a target or biological sample.

50. The method, use, or compound for use according to any one of claims 47 to 49, wherein the protein is p300 or CBP.

51. A method for treating a p300-mediated disorder, comprising administering a compound according to any one of claims 1 to 45 to a patient in need thereof.

52. Use of a compound according to any one of claims 1 to 45 in the manufacture of a pharmaceutical product for treating a p300-mediated disorder.

53. A compound according to any one of claims 1 to 45, for use in the treatment of p300-mediated disorders.

54. The method, use, or compound for use according to any one of claims 51 to 53, wherein the p300-mediated disorder is cancer, an inflammatory disorder, or an autoimmune disease.

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