Hydrogen Peroxide Disinfectant Compositions

Abstract

The present invention provides herein a disinfectant composition comprising: a) an effective amount of a hydrogen peroxide source; b) a blend of at least one aromatic alcohol and at least one glycol or glycol ether; c) at least one nonionic and / or anionic surfactant; and d) at least one acid. Also provided is a method of using the disinfectant composition, whereby the composition can be applied to any surface and effectively kill a majority of M. tuberculosis and / or M. terrae microorganisms, resulting in a >5 log reduction in a contact time of 5 minutes or less.

Description

[Technical field]

[0001]

[0001]

[0002] The present disclosure relates to disinfectant compositions containing hydrogen peroxide and a novel solvent system that are effective against tuberculosis-containing bacteria. [Background technology]

[0002]

[0003]

[0004] Among known disinfectants and antimicrobial agents, hydrogen peroxide is a suitable choice not only because of its potential as a biocide, but also because of its low toxicity, which decomposes into non-toxic oxygen and water. Furthermore, hydrogen peroxide's inherent ability to kill a broad range of microorganisms combined with the low toxicity of the products makes it an ideal active for disinfectant formulations for non-hard, porous surfaces.

[0003]

[0005] Unfortunately, hydrogen peroxide alone is not able to kill higher levels of organisms such as Mycobacterium tuberculosis, especially when it is difficult to provide shorter kill times (preferably <5 minutes). Thus, hydrogen peroxide is not very effective against certain organisms by itself. Hydrogen peroxide is not effective against Mycobacterium tuberculosis even with high activity levels and long contact times. Furthermore, most commercial hydrogen peroxide-based products are unable to kill Mycobacterium tuberculosis (TB) on hard surfaces within short contact times.

[0004]

[0006] There is a need in the art to provide the hospital disinfectant market with a disinfectant product that is effective in killing tuberculosis-causing bacteria and that exhibits rapid disinfecting properties after application to a surface. Summary of the Invention

[0005]

[0008] It has now surprisingly been found that the combination of hydrogen peroxide and a novel solvent system is effective against tuberculosis-containing bacteria, with an effective bactericidal activity of >5 log reduction against the causative agent of tuberculosis with a contact kill time of 5 minutes or less.

[0006]

[0009] The present disclosure answers the need for disinfectant compositions containing hydrogen peroxide that are effective against tuberculosis-causing bacteria even at high activity levels. The present invention provides a disinfectant composition effective against M. tuberculosis and / or M. terrae that contains an acidified hydrogen peroxide solution having a pH of 0-5 and a novel solvent system. The composition provides effective kill against M. tuberculosis with a >5 log reduction in a contact kill time of 5 minutes or less.

[0007]

[0010] In one aspect, the present invention provides a disinfectant composition comprising: a) an effective amount of a hydrogen peroxide source; b) at least one aromatic alcohol; c) at least one glycol or glycol ether; d) at least one nonionic and / or anionic surfactant; and e) at least one acid.

[0008]

[0011] In one embodiment, the hydrogen peroxide source comprises a hydrogen peroxide solution, sodium percarbonate, potassium percarbonate, sodium perborate, potassium perborate, urea hydrogen peroxide or a peroxide salt, a hydrated salt thereof, or a combination thereof.

[0009]

[0012] In one embodiment, the concentration of the hydrogen peroxide source is from 0.01 w / w% to about 90 w / w% of the total weight of the composition.

[0013] In one embodiment, at least one aromatic alcohol is present, including anisyl alcohol (anis alcohol), benzyl alcohol, phenoxyethanol, vanillyl alcohol, phenols, polyphenols, derivatives thereof, or salts thereof.

[0010]

[0014] In another embodiment, at least one glycol or glycol ether is present comprising butylene glycol, diethylene glycol monomethyl ether, diethylene glycol monobutyl ether, diethylene glycol monoethyl ether, diethylene glycol mono-n-butyl ether, dipropylene glycol butyl ether, dipropylene glycol methyl ether, diethylene glycol propyl ether, ethylene glycol, ethylene glycol monomethyl ether, ethylene glycol monoethyl ether, ethylene glycol monopropyl ether, ethylene glycol monoisopropyl ether, ethylene glycol monobutyl ether, ethylene glycol dimethyl ether, ethylene glycol diethyl ether, ethylene glycol dibutyl ether, propylene glycol, propylene glycol n-butyl ether, tripropylene glycol methyl ether, triethylene glycol monobutyl ether, or combinations thereof.

[0011]

[0015] In one particular embodiment, the at least one aromatic alcohol and the at least one glycol or glycol ether are present as a blend, the blend being in a ratio of 1:100 to 100:1.

[0012]

[0016] In one embodiment, the blend of at least one aromatic alcohol and at least one glycol or glycol ether is present in an amount of about 0.01% to 90% w / w of the total composition.

[0013]

[0017] In one particular embodiment, at least one nonionic and / or anionic surfactant is present in an amount, the total amount of surfactants present being from 0.01 w / w% to 15 w / w% of the total composition.

[0014]

[0018] In another embodiment, the at least one acid comprises an organic acid, an inorganic acid, a carboxylic acid, a mineral acid, a non-surfactant sulfonic acid, or a salt thereof.

[0019] In one embodiment, the total amount of acid is present in an amount between 0.01% and 15% w / w of the total composition.

[0015]

[0020] In yet another embodiment, the composition further comprises a peroxide stabilizer and / or chelator, wherein the stabilizer and / or chelator is present in an amount of 0.01 w / w% to 5 w / w% based on the weight of the total composition.

[0016]

[0021] In one embodiment, the composition has a pH of about 0 to about 5.

[0022] In yet another embodiment, the composition further comprises a second biocide present in an amount between 0.01% w / w and 20% w / w.

[0017]

[0023] In one particular embodiment, the composition comprises a concentrate, while in another embodiment, the composition comprises a ready-to-use composition upon dilution with an aqueous solvent, a non-aqueous solvent, or a mixture thereof.

[0018]

[0024] In further embodiments, the composition is effective against one or more microorganisms including gram positive bacteria, gram negative bacteria, viruses, fungi, mildew, mold, or combinations thereof.

[0019]

[0025] In another embodiment, the composition is effective against M. tuberculosis and / or M. terrae.

[0026] In one particular embodiment, the composition provides effective kill of >5 log reduction with a contact time of 5 minutes or less.

[0020]

[0027] In one particular embodiment, the present invention provides a composition according to the present invention, comprising: a) an effective amount of a hydrogen peroxide source, said hydrogen peroxide source comprising a hydrogen peroxide solution; b) at least one aromatic alcohol, said alcohol comprising benzyl alcohol and / or phenoxyethanol; c) at least one glycol or glycol ether, said glycol comprising diethylene glycol monobutyl ether, triethylene glycol monobutyl ether; d) at least one nonionic and / or anionic surfactant, said surfactant comprising C 12 -C 15 Ethoxylated alcohols, C 12 -C 14 a) at least one acid, said acid comprising methanesulfonic acid; and b) at least one secondary ethoxylated alcohol 70%, 2-ethylhexanol EO-PO nonionic surfactant, caprylyl / decyl glucoside, and / or linear alkylbenzene sulfonic acid; and c) at least one acid, said acid comprising methanesulfonic acid, said composition being effective against M. tuberculosis and / or M. terrae.

[0021]

[0028] In another aspect, the present invention provides a method for disinfecting a surface from M. tuberculosis and / or M. terrae, said method comprising adding an effective amount of a disinfectant composition according to the present invention and applying said composition to the surface in an amount that effectively kills a majority of microorganisms present on said surface.

[0022]

[0029] In another aspect, the method includes a disinfectant composition for inhibiting the growth of and / or reducing the number of viable microorganisms among one or more microorganisms.

[0030] In one aspect, the surface is a hard or soft surface including a floor, a wall, a countertop, an appliance, a fixture, a fabric, a textile, or any other hard or soft surface.

[0023]

[0031] In yet a further aspect, the present invention provides a method for enhancing the disinfecting properties of a hydrogen peroxide source, the method comprising combining sufficient amounts of b) at least one aromatic alcohol; c) at least one glycol or glycol ether; d) at least one nonionic and / or anionic surfactant; and e) at least one acid with a hydrogen peroxide source and applying the composition to a surface.

[0024]

[0032] In another aspect, the present invention provides a disinfectant composition comprising: b) at least one aromatic alcohol; c) at least one glycol or glycol ether; d) at least one nonionic and / or anionic surfactant; and e) at least one acid, the composition being effective against M. tuberculosis and / or M. terrae, and the composition being capable of being diluted with a solvent to form a ready-to-use composition.

[0025]

[0033] In one particular embodiment, the present invention provides a two-part disinfectant comprising: a) a first container containing a biocidal amount of hydrogen peroxide and a solvent; b) at least one aromatic alcohol; c) at least one glycol or glycol ether; d) at least one nonionic and / or anionic surfactant; and e) a second container containing at least one acid.

[0026]

[0034] In one embodiment, the two-part disinfectant is effective against M. tuberculosis and / or M. terrae, wherein the disinfectant provides a >5 log reduction with a contact time of 5 minutes or less.

[0035] In yet a further aspect, the present invention provides an additive for a disinfectant composition comprising: b) at least one aromatic alcohol; c) at least one glycol or glycol ether; d) at least one nonionic and / or anionic surfactant; and e) at least one acid, said additive enhancing the disinfecting properties of said composition when combined with a disinfectant active.

[0027]

[0036] In one aspect, the disinfectant active comprises a hydrogen peroxide solution, alcohol, bleach, an organic acid, or phenol. DETAILED DESCRIPTION OF THE PREFERRED EMBODIMENTS

[0028]

[0038] The present invention provides disinfectant compositions containing a source of hydrogen peroxide that are effective against M. tuberculosis and / or M. terrae, having a >5 log reduction in a contact time of 5 minutes or less. These and other aspects will become apparent from a reading of the detailed description of the invention.

[0029]

[0039] As used herein, the term "effective amount" refers to any amount that will produce a desired effect based on the known purpose and function of the ingredients and application of the composition. What constitutes an effective amount would be determinable by one of ordinary skill in the art without necessitating inventive experimentation.

[0030]

[0040] It has now surprisingly been discovered that the combination of an acidified hydrogen peroxide solution having a pH of 0-5 and a novel organic solvent system provides a composition that exhibits a >5 log reduction against M. terrae and / or tuberculosis in a contact time of 5 minutes or less.

[0031]

[0041] In one aspect of the invention, there is provided a disinfectant composition comprising: a) an effective amount of a source of hydrogen peroxide; b) at least one aromatic alcohol; c) at least one glycol or glycol ether; d) at least one nonionic and / or anionic surfactant; and e) at least one acid.

[0032]

[0042] The disinfectant compositions described in the present invention are concentrates and / or ready-to-use compositions.

[0043] Typically, sources of hydrogen peroxide include, but are not limited to, hydrogen peroxide solutions, percarbonates (i.e., sodium percarbonate, potassium percarbonate), perborates (i.e., sodium perborate, potassium perborate), hydrogen peroxide urea or peroxide salts, hydrated salts thereof, or combinations thereof, and the like.

[0033]

[0044] Typically, the concentration of the hydrogen peroxide source is 0.01 w / w% to about 90 w / w% of the total weight of the composition. The hydrogen peroxide source present in the disinfectant composition is typically present in an amount of 0.1 w / w% to about 50 w / w% based on the total weight of the composition. Suitably, the concentration of the hydrogen peroxide source is 0.5 w / w% to about 20 w / w% based on the total weight of the composition. Desirably, the concentration of the hydrogen peroxide source is 0.01 w / w% to about 15 w / w% of the total weight of the composition. In ready-to-use form, typically, the amount of hydrogen peroxide is 0.01 w / w% to 15 w / w% of the total composition; suitably, 0.1 w / w% to 10 w / w% or desirably, 0.01 w / w% to 7 w / w%.

[0034]

[0045] Typically, at least one aromatic alcohol is present in the composition, including, but not limited to, anisyl alcohol (anis alcohol), benzyl alcohol, phenoxyethanol, vanillyl alcohol, phenols, polyphenols, derivatives thereof, or salts thereof. Suitably, the at least one aromatic alcohol comprises benzyl alcohol and / or phenoxyethanol.

[0035]

[0046] Typically, the at least one aromatic alcohol is present in an amount of about 0.01 w / w% to 50 w / w% based on the weight of the total composition. Suitably, the at least one aromatic alcohol is present in an amount of about 0.1 w / w% to 25 w / w%, preferably about 0.1 w / w% to 15 w / w%, based on the weight of the total composition.

[0036]

[0047] Typically, examples of glycols or glycol ethers include, but are not limited to, butylene glycol, diethylene glycol monomethyl ether, diethylene glycol monobutyl ether, diethylene glycol monoethyl ether, diethylene glycol mono-n-butyl ether, dipropylene glycol butyl ether, dipropylene glycol methyl ether, diethylene glycol propyl ether, ethylene glycol, ethylene glycol monomethyl ether, ethylene glycol monoethyl ether, ethylene glycol monopropyl ether, ethylene glycol monoisopropyl ether, ethylene glycol monobutyl ether, ethylene glycol dimethyl ether, ethylene glycol diethyl ether, ethylene glycol dibutyl ether, propylene glycol, propylene glycol n-butyl ether, tripropylene glycol methyl ether, triethylene glycol monobutyl ether, or combinations thereof, etc. Suitably, the at least one glycol or glycol ether includes diethylene glycol monobutyl ether, and / or triethylene glycol monobutyl ether.

[0037]

[0048] Typically, the at least one glycol or glycol ether is present in an amount of about 0.01% to 50% w / w based on the weight of the total composition. Suitably, the at least one glycol or glycol ether is present in an amount of about 0.1% to 25% w / w based on the weight of the total composition; or desirably, in an amount of about 0.1% to 15% w / w based on the weight of the total composition.

[0038]

[0049] If desired, the composition contains a novel solvent system, whereby the solvent system is a) at least one aromatic alcohol, and / or b) at least one glycol or glycol ether, or c) a blend of at least one aromatic alcohol and at least one glycol or glycol ether. If desired, typically the blend of at least one aromatic alcohol and at least one glycol or glycol ether is present in a ratio of 1:100 to 100:1. Suitably, the blend is in a ratio of 1:50 to 50:1; or desirably, the blend is in a ratio of 1:20 to 20:1.

[0039]

[0050] Typically, the blend of at least one aromatic alcohol and at least one glycol or glycol ether is present in an amount of about 0.01 w / w% to 90 w / w% of the total composition, suitably the blend is present in an amount of about 0.1 w / w% to 75 w / w% or suitably the blend is present in an amount of about 0.1 w / w% to 50 w / w% based on the weight of the total composition.

[0040]

[0051] For example, the disinfectant composition contains a blend of benzyl alcohol and / or phenoxyethanol with diethylene glycol monobutyl ether and / or triethylene glycol monobutyl ether in a ratio of 1:100 to 100:1, whereby the typical total amount of the blend is in an amount of about 0.01 w / w% to 90 w / w% based on the weight of the entire composition.

[0041]

[0052] If desired, the composition further comprises at least one nonionic surfactant and / or anionic surfactant, whereby the total amount of surfactant present is in an amount of from 0.01% to 15% by weight of the total composition, suitably from about 0.01% to 10% by weight of the total composition.

[0042]

[0053] Typically, the nonionic surfactant includes at least one of, but is not limited to, ethoxylated fatty alcohols, polyoxyethylene surfactants, polyethylene glycol esters, sorbitol anhydride esters and their ethoxylated derivatives, glycol esters, carboxylic acid amides, monoalkanolamine condensates, polyoxyethylene fatty acid amides, or combinations thereof.

[0043]

[0054] Suitably, examples of the at least one nonionic surfactant include, but are not limited to, caprylyl / capryl glucoside, C8-C 15 Ethoxylated Alcohols, C8-C 14 Secondary Ethoxylated Alcohol 70%, 2-Ethylhexanol EO-PO Nonionic Surfactant, C8-C 14 Alkylated Polyethylene Glycol, C8-C 14 alkylated polypropylene glycol, polyoxyethylene glycol alkylphenol ethers, and glucoside alkyl ethers, polyoxyethylene glycol alkyl ethers, octaethylene glycol monododecyl ether, pentaethylene glycol monododecyl ether, polyoxypropylene glycol alkyl ethers, glucoside alkyl ethers, decyl glucoside, lauryl glucoside, octyl glucoside, polyoxyethylene glycol octylphenol ether, polyoxyethylene glycol alkylphenol ethers, glycerol alkyl esters, polyglycerol esters, glyceryl laurate, polyoxyethylene glycol sorbitan alkyl esters, sorbitan alkyl esters, dodecyl dimethylamine oxide, block copolymers of polyethylene glycol and polypropylene glycol, poloxamer and polyethoxylated tallowamine (POEA), or mixtures thereof.

[0044]

[0055] Typically, examples of anionic surfactants include, but are not limited to, at least one anionic surfactant, such as, but not limited to, linear alkylbenzene sulfonic acid, alkylbenzene sulfonate, alkyl sulfate / sulfonate, alkanolamide sulfate, ethoxylated alkylphenol, linear alkylbenzene sulfonate, alkyl sulfate, alkoxylated alkyl sulfate, or combinations thereof.

[0045]

[0056] The composition contains at least one acid, such as, but not limited to, an organic acid, an inorganic acid, a carboxylic acid, a mineral acid, a non-surfactant sulfonic acid, or a salt thereof. The total amount of acid present in the composition is from 0.01% to 15% by weight of the total composition. Suitably, in the case of a concentrate or ready-to-use form, it is from 0.01% to 10% by weight; preferably from 0.01% to 5% by weight.

[0046]

[0057] Suitably, examples of the at least one acid include, but are not limited to, citric acid, lactic acid, glycolic acid, tartaric acid, formic acid, acetic acid, phosphoric acid, oxalic acid, propionic acid, or methanesulfonic acid, butyric acid, pentanoic acid, hexanoic acid, octanoic acid, succinic acid, glutaric acid, adipic acid, benzoic acid, phthalic acid, mixtures thereof, and the like.

[0047]

[0058] Typically, concentrated forms of the disinfectant composition have a pH of about 0 to 5; suitably 1 to about 3. For ready-to-use solutions, the pH may be about 0.5 to about 4.5, suitably 0.5 to 3.

[0048]

[0059] It may be desirable to include one or more additional ingredients in the composition, such as, but not limited to, a biocide, a solvent, a corrosion inhibitor, an emulsifier, a fragrance, a dye, a preservative, an antifoam agent, a thickener, a hydrotrope, a second biocide, a sequestering / chelating agent, an aid stabilizing solubilizer, an aqueous solvent, or mixtures thereof.

[0049]

[0060] When stabilizers and / or chelating agents are added, the stabilizers include, but are not limited to, peroxide stabilizers present in an amount of 0.01 w / w% to 5 w / w% based on the weight of the total composition.

[0050]

[0061] Typically, the stabilizers / chelating agents include, but are not limited to, amino carboxylic acid based products, phosphates and phosphonates, hydroxy carboxylates, polyacrylates, sugar acrylates, polymeric clarifiers, dichlor, trichlor, cyanuric acid, organic and / or inorganic sequestering agents, and the like.

[0051]

[0062] Examples of phosphate sequestering agents are inorganic polyphosphates such as sodium hexametaphosphate (SHMP), sodium polyphosphate, sodium tripolyphosphate, sodium trimetaphosphate, sodium pyrophosphate, combinations thereof, and the like.

[0052]

[0063] Examples of phosphonated aminopolycarboxylates are, for example, ethylenediaminetetra(methylenephosphonic acid) (EDTMP), diethylenetriaminepentamethylenephosphonic acid (DETMP), aminotris(methylenephosphonic acid) (ATMP), diethylenetriaminepenta(methylenephosphonic acid) (DTPMP), HEDP, or salts thereof; combinations thereof, and the like.

[0053]

[0064] Suitable examples of stabilizing / chelating agents include, but are not limited to, phosphoric acid, 1-hydroxyethylidene diphosphonic acid (HEDP), phytic acid, aminophosphates, phosphonates, and sodium glutamate, NaH2PO4, Na5PO3. 10, organic phosphonic acids, amino-phosphonates, silver dihydrogen citrate, diphosphonic acids, ethylenediaminetetraacetic acid (EDTA), N-(hydroxyethyl)-ethylenediaminetriacetic acid (HEDTA), tri(methylenephosphonic acid), diethylenetriaminepenta(methylene phosphate), 2-hydroxyethyliminobis(ethylene phosphate), citric acid, dipicolinic acid, ethylenediamine-N,N'-disuccinic acid, methylglycine diacetic acid and their alkali salts, nitrilotriacetic acid (NTA), 2-hydroxyethylimino-diacetic acid (HEIDA) ), and its salts, cyclohexane-1,2-diaminotetrakismethylenephosphonic acid or watersol, diethylenetriaminepenta(methylenephosphonic acid), colloidal stannate, diethylenetriaminepentaacetic acid (DTPA), citrate, gallate, malate, malonate, oxaloacetate, oxalate, pyruvate, succinate, 2-hydroxypyridine-1-oxide (2-HPNO), hydroxyethylidene diphosphonic acid (HEDP) zinc salt, triethanolamine phosphate, or mixtures thereof.

[0054]

[0065] Typically, when a biocide is added to a disinfectant composition, it acts as a second biocide in the composition, whereby it is present in an amount of 0.01% to 40 w / w%, or suitably 0.01 w / w% to 25 w / w%, based on the weight of the total composition.

[0055]

[0066] Examples of second biocides include, but are not limited to, halogen releasing compounds; quaternary ammonium compounds (including quaternary ammonium halides, sulfates, phosphates, nitrates, or combinations thereof, such as benzylalkonium chloride), isothiazolones or mixtures thereof, pyrithiones, glutaraldehyde, iodopropynyl butylcarbamate (IPBC), polyhexamethylene biguanide (PHMB), bronopol, amines (e.g., bis(3-aminopropyl)dodecylamine), metal salts, poly(oxyethylene(dimethylimino)ethylene(dimethylimino)ethylene dichloride), sodium dimethyldithiocarbamate, 2-chloro-4,6-bis(ethylamino)-5-triazine, oxidizers, combinations thereof, and the like.

[0056]

[0067] Examples of halogen-releasing compounds include, but are not limited to, chlorinated isocyanuric acid or its salts, isothiazolinone or mixtures of isothiazolinones; halogenated hydantoins, hypochlorous acid or its salts, chlorine gas, chlorine dioxide, hypobromite salts, hypobromous acid; and compatible combinations thereof; essentially free of any peracid-based solutions, derivatives or salts thereof.

[0057]

[0068] Examples of chlorinated isocyanuric acids or salts thereof include, but are not limited to, trichloroisocyanuric acid (TCCA) and dichloroisocyanuric acid (DCCA); dichloroisocyanurates (e.g., sodium dichloroisocyanurate, potassium dichloroisocyanurate), trichloroisocyanurates (e.g., sodium or potassium trichloroisocyanurate), combinations thereof, and the like.

[0058]

[0069] Examples of chlorinated halogenated hydantoins are those containing both chlorine and bromine, such as bromochlorodimethylhydantoin (BCDMH); dibromodimethylhydantoin (DBDMH), dichlorodimethylhydantoin (DCDMH), dichloromethylethylhydantoin (DCMEH), combinations thereof, and the like.

[0059]

[0070] Hypochlorites; Examples of hypochlorous or hypobromous acids and their salts include, but are not limited to, lithium hypochlorite, sodium hypochlorite, potassium hypochlorite, magnesium hypochlorite, calcium hypochlorite, combinations thereof, and the like.

[0060]

[0071] Examples of metal salts include, but are not limited to, zinc chloride, zinc oxide, aluminum sulfate, copper sulfate, copper citrate, copper EDTA (ethylenediaminetetraacetic acid), copper gluconate, colloidal silver, silver nitrate, potassium monopersulfate, sodium perborate, sodium percarbonate, combinations thereof, and the like.

[0061]

[0072] The disinfectant compositions described in the present invention are concentrates and / or ready-to-use compositions. The concentrated compositions are thereby diluted with an aqueous solvent, a non-aqueous solvent or a mixture thereof to provide a ready-to-use composition for consumers. When diluted, the hydrogen peroxide source is present in an amount of 0.01 w / w% to 20 w / w% based on the weight of the total composition. Suitably, 0.1 w / w% to 15 w / w% based on the weight of the total composition; desirably, 0.1 w / w% to 8 w / w% based on the weight of the total composition.

[0062]

[0073] Typically, the solvent is an aqueous solvent, a non-aqueous solvent, or a mixture thereof, and is present in an amount to equal 100% of the total composition. For example, the solvent is a straight or branched chain water-soluble alcohol, water.

[0063]

[0074] Examples of aqueous solvents include, but are not limited to, water, aqueous alcohol, aqueous ammonia, acid solutions, hydrogen peroxide solutions, salt solutions, water-miscible organic solvents, alkanolamines, or glycol ethers, combinations thereof, and the like.

[0064]

[0075] Examples of non-aqueous solvents include, but are not limited to, non-aqueous alcohols, monohydric or polyhydric alcohols, alkanolamines, or glycol ethers, any substance that is immiscible in water, mixtures thereof, and the like.

[0065]

[0076] Suitably the solvent used is water, an aqueous alcohol, a glycol ether, an aromatic alcohol or blends thereof.

[0077] The disinfectant composition is effective against one or more microorganisms including, but not limited to, gram positive bacteria, gram negative bacteria, viruses, fungi, mildews, molds, or combinations thereof.

[0066]

[0078] Specifically, the microorganism may thereby be, but is not limited to, Staphylococcus aureus, Pseudomonas aeruginosa, Hepatitis virus, Rotavirus, Rhinovirus, Tuberculin, or a combination thereof.

[0067]

[0079] Desirably, the disinfectant composition has high efficacy against tuberculosis-causing bacteria, including, but not limited to, M. terrae. The composition exhibits a >5 log reduction against M. terrae in a contact time of 5 minutes or less. Specifically, the disinfectant composition thereby exhibits a >5 log reduction against M. terrae in a contact time of about 3 minutes.

[0068]

[0080] One aspect of the invention, as described herein, comprises a) an effective amount of a hydrogen peroxide source, said hydrogen peroxide source comprising a hydrogen peroxide solution; b) at least one aromatic alcohol, said alcohol comprising benzyl alcohol and / or phenoxyethanol; c) at least one glycol or glycol ether, said glycol comprising diethylene glycol monobutyl ether, triethylene glycol monobutyl ether; d) at least one nonionic and / or anionic surfactant, said surfactant comprising at least one surfactant selected from the group consisting of C 12 -C 15 Ethoxylated alcohols, C 12 -C 14a) at least one acid, said acid comprising methanesulfonic acid; and b) at least one ethoxylated alcohol 70%, 2-ethylhexanol EO-PO nonionic surfactant, caprylyl / decyl glucoside, and / or linear alkylbenzene sulfonic acid; and c) at least one acid, said acid comprising methanesulfonic acid, said composition being effective against M. tuberculosis and / or M. terrae.

[0069]

[0081] Another aspect of the invention provides a method for disinfecting a surface from M. tuberculosis and / or M. terrae, said method comprising applying to the surface an effective amount of a disinfectant composition according to the invention in an amount effective to kill a majority of microorganisms present on said surface.

[0070]

[0082] The described method provides a disinfectant composition for inhibiting the growth of one or more microorganisms therein and / or reducing the number of viable microorganisms. Specifically, the disinfectant composition according to the present invention exhibits a >5 log reduction in a contact time of 5 minutes or less. Suitably, the disinfectant composition according to the present invention exhibits a >5 log reduction in a contact time of 3 minutes.

[0071]

[0083] Typically the surface is a hard or soft surface including, but not limited to, floors, walls, countertops, appliances, fixtures, fabrics, textiles, upholstery, other hard surfaces, soft surfaces, or any surface requiring treatment against microorganisms; suitably, against tuberculosis-containing bacteria and / or M. terrae.

[0072]

[0084] Examples of soft surfaces include, but are not limited to, upholstery, fabric, upholstered couches, sofas, chairs, seat cushions, upholstered cushions, pillows, upholstered furniture, fabric window treatments, curtains, drapes, shower curtains, fabric gym / laundry / diaper bags, backpacks, fabric hampers, fabric dog / pet bedding, blankets, fabric car seats, fabric stuffed animals, toys, and the like.

[0073]

[0085] For example, the compositions of the present invention provided sanitizing or disinfecting properties to hard non-porous surfaces. The compositions of the present invention are well suited for disinfecting or sanitizing flooring materials, countertops, ceramic surfaces, metal surfaces, glass surfaces, stone surfaces, and the like.

[0074]

[0086] The compositions can be used to clean surfaces, destroy microorganisms on surfaces, and / or prevent the growth of microorganisms on surfaces. Similarly, the compositions can be used in the food service industry to disinfect and sanitize food processing equipment and other food processing surfaces, or to clean produce such as vegetables. The compositions can also be used in the health care industry to disinfect surfaces, facilities, equipment, and hospital equipment and facilities, and / or sanitize instruments.

[0075]

[0087] Killing of Mycobacterium terrae (M. terrae) was evaluated using the OECD Quantitative Method for Evaluating the Bactericidal and Mycobactericidal Activity of Microbicides. This method provides a quantitative assessment of the performance against M. terrae of liquid antimicrobials designed for hard nonporous surfaces. The method is based on a guidance document from the Organization for Economic Cooperation and Development (OECD) and provides the log reduction (LR) as a quantitative measure of the efficacy of liquid disinfectants. The log reduction of M. terrae 10 The log reduction is often used as a preliminary screening tool to determine potential efficacy against M. tuberculosis, which is generally recognized as being more difficult to kill and more challenging to work with in the laboratory. 10 Reduction was assessed using a 3 minute contact time and 5% soil.

[0076]

[0088] In another aspect, the invention provides a method for enhancing the disinfecting properties of a hydrogen peroxide source, the method comprising combining a sufficient amount of b) at least one aromatic alcohol; c) at least one glycol or glycol ether; d) at least one nonionic and / or anionic surfactant; and e) at least one acid with a hydrogen peroxide source and applying the composition to a surface.

[0077]

[0089] In yet another aspect, the present invention provides a disinfectant composition comprising: b) at least one aromatic alcohol; c) at least one glycol or glycol ether; d) at least one nonionic and / or anionic surfactant; and e) at least one acid, the composition being effective against M. tuberculosis and / or M. terrae, and the composition being capable of being diluted with a solvent to form a ready-to-use composition.

[0078]

[0090] Solvents used to form the ready-to-use composition include, but are not limited to, a hydrogen peroxide source, an aqueous solvent, a non-aqueous solvent, or mixtures thereof. Examples of such solvents are described above.

[0079]

[0091] In a further aspect, the present invention provides a two-part disinfectant comprising: a) a first container containing a biocidal amount of hydrogen peroxide and a solvent; b) at least one aromatic alcohol; c) at least one glycol or glycol ether; d) at least one nonionic and / or anionic surfactant; and e) a second container containing at least one acid.

[0080]

[0092] Typically, the two-part disinfectant is effective against M. tuberculosis and / or M. terrae, the disinfectant providing a >5 log reduction in a contact time of 5 minutes or less.Suitably, the two-part disinfectant composition provides a >5 log reduction in a contact time of 3 minutes.

[0081]

[0093] In another aspect, the present invention provides an additive for a disinfectant composition comprising: b) at least one aromatic alcohol; c) at least one glycol or glycol ether; d) at least one nonionic and / or anionic surfactant; and e) at least one acid, said additive enhancing the disinfecting properties of said composition when combined with a disinfectant active.

[0082]

[0094] Typically, disinfectant actives include, but are not limited to, hydrogen peroxide solutions, alcohols, oxidizing agents, metal salts, halogens, bleaches, phenols, antibiotic creams, pharmaceutical actives, astringents, antihistamines, analgesics, skin cleansers / cleaners, antifungal / antimicrobial / antibacterial agents, or essential oils, natural extracts, or other actives with disinfecting properties, combinations thereof, and the like.

[0083]

[0095] The invention is illustrated without limitation by the following examples. All parts and percentages are by weight unless otherwise indicated. EXAMPLES

[0084]

[0096] Example 1. Formulation

[0097] Table 1. Formulations

[0085] [Table 1]

[0086]

[0098] All formulation solutions in Table 1 can be present in their neat (ready to use) state or can be concentrated in two basic ways (shown as an example in Table 7 using Formulation 2). The first way is, for example but not limited to, simply making a 1:4 concentrate (which will be diluted with the appropriate amounts of hydrogen peroxide and water).

[0087]

[0099] Formulation 5 in Table 1 is an acidified hydrogen peroxide formulation containing a surfactant, but the solvent blend was not included in the composition, resulting in a low log reduction of M. terrae (see Table 2). Formulation 3 contains the ingredients of formulation 5 plus a new solvent blend, and showed a dramatic increase in the log reduction of M. terrae. Formulation 4 contains the ingredients of formulation 5 plus half the diethylene of the solvent blend, and showed little log reduction of M. terrae. Formulation 1 contains a new solvent blend ratio in the formulation, and showed a dramatic increase in the log reduction of M. terrae. Formulation 2 is similar to 4, but also contains 1.5% phenoxyethanol, which increased the log reduction of M. terrae. Formulation 6 is similar to 2, but the level of phenoxyethanol (amount, concentration) was doubled along with the butyl carbitol level, which dramatically increased the log reduction of M. terrae.

[0088]

[0100] It is important to note that the solvent blends containing glycol ethers and phenoxyethanol (formulations 7 and 2) had an increasing effect on the efficacy of M. terrae and TB. What is even more unexpected is that formulation 2, despite having a lower level of the solvent blend, managed to pass TB.

[0089]

[0101] Example 2. OECD Test Method for M. terrae with 3 minute contact time

[0102] Table 2. Results of OECD test methods for M. terrae

[0090] [Table 2]

[0091]

[0103] TB was evaluated using the tuberculinicidal test of the AOAC Germicidal Spray Test. This test involves testing Mycobacterium bovis (BCG) ATCC 35743 cultured in 7H11 growth medium for 21 ± 2 days at 36 ± 1°C. According to regulatory agency (EPA) guidelines, all formulations passed, no visible growth was observed in any of the subculture broth tubes per lot, and the controls met their prescribed criteria. All formulations passed BCG when tested as described above (containing 5% organic soil load, 3 minutes contact). All test controls met the established criteria for valid testing.

[0092]

[0104] However, what was particularly surprising was the significant effect that the solvent blends containing glycol ethers and phenoxyethanol (formulations 7 and 2) had on potency enhancement of M. terrae and TB. Even more unexpectedly, formulation 2, which contained an even lower level of the solvent blend, managed to pass TB.

[0093]

[0105] Example 3. TB Evaluation (Pass / Fail)

[0106] Table 3. TB rating at 3 min contact time

[0094] [Table 3]

[0095]

[0107] Example 4. Stability test

[0108] Table 4. Physical stability tests of disinfectant compositions

[0096] [Table 4]

[0097]

[0109] Formulations 1, 7, and 2 were filled into 4 ounce (113 g) glass jars with lids and placed into various controlled temperature ovens. Samples were removed and visually evaluated at the times and temperatures listed in Table 4. At the end of the four week period, all samples were found to have acceptable physical stability.

[0098]

[0110] Example 5. Stability of Hydrogen Peroxide

[0111] Table 5. Stability of hydrogen peroxide

[0099] [Table 5]

[0100]

[0112] The same formulations tested in Table 4 were also tested for H2O2 stability at 50° C. for 4 weeks (see Table 5). All formulations had fairly good peroxide stability with no greater than 6% w / w loss in H2O2 at 50° C. for 4 weeks.

[0101]

[0113] Calculate the percent reduction of hydrogen peroxide: % H2O2 reduction = (initial amount of H2O2 - amount of H2O2 after storage) / initial amount of H2O2, multiply this result by 100.

[0114] Example 6. AOAC Germicidal Spray Method for Disinfecting Hard Surfaces

[0115] Table 6. AOAC Germicidal Spray Methods for Disinfecting Hard Surfaces

[0102] [Table 6]

[0103]

[0116] Formulation 2 was micro tested against S. enterica, S. aureus, and P. aeruginosa using the AOAC germicidal spray method for hard surface disinfection under GLP conditions with a 5% soil load (fetal bovine serum) and a 1 minute contact time (see Table 6). Formulation 2 passed against all three organisms under GLP conditions.

[0104]

[0117] Example 7. Formulation No. 2

[0118] Table 7. Comparison of Formulation No. 2 (w / w%)

[0105] [Table 7]

[0106]

[0119] All formulation solutions in Table 1 can be present in their neat (ready to use) state or can be concentrated in two basic ways (shown as an example in Table 7 using Formulation 2). The first way is, for example but not limited to, simply making a 1:4 concentrate (which will be diluted with the appropriate amounts of hydrogen peroxide and water).

[0107]

[0120] Example 8. Concentrate pack formulation of Formulation No. 2

[0121] Table 8. Comparison of pack formulations of concentrates A and B

[0108] [Table 8]

[0109]

[0122] The second method is similar to the first, but instead of just removing the hydrogen peroxide from the concentrate, two solvents are also removed (Table 7).The concentrate is then diluted with water, hydrogen peroxide, and / or a solvent pack containing diethylene glycol monobutyl ether and phenoxyethanol (Table 8).

[0110]

[0123] It will be understood that each of the elements described in the above examples, or combinations of two or more together, may also find useful application in other types of methods different from those described above. Without further analysis, the above sufficiently discloses the gist of the present disclosure that others may readily adapt it to various applications by applying their current knowledge without omitting features that, in the light of the prior art, fairly constitute essential features of the general or specific aspects of the present disclosure as set forth in the appended claims.

[0111]

[0124] The foregoing embodiments have been presented by way of example only; the scope of the present disclosure is intended to be limited only by the following claims.

[0125] While the invention has been described above with reference to specific embodiments thereof, it will be apparent that many changes, modifications and variations are possible without departing from the inventive concept disclosed herein, and it is therefore intended to embrace all such changes, modifications and variations that fall within the spirit and broad scope of the appended claims.

Claims

1. 1. A disinfectant composition comprising: a) an effective amount of a hydrogen peroxide source; b) at least one aromatic alcohol; c) at least one glycol or glycol ether; d) at least one nonionic and / or anionic surfactant; and e) at least one acid; The at least one nonionic and / or anionic surfactant is １２ -C １５ Ethoxylated Alcohols, C １２ -C １４ The disinfectant composition comprises 70% secondary ethoxylated alcohol, 2-ethylhexanol EO-PO nonionic surfactant, caprylyl / decyl glucoside, and / or linear alkyl benzene sulfonic acid.

2. 10. The disinfectant composition of claim 1, wherein the hydrogen peroxide source comprises hydrogen peroxide solution, sodium percarbonate, potassium percarbonate, sodium perborate, potassium perborate, urea hydrogen peroxide or a peroxide salt, a hydrated salt thereof, or a combination thereof.

3. 3. The disinfectant composition of claim 2, wherein the concentration of the hydrogen peroxide source is from 0.01 w / w% to about 90 w / w% of the total weight of the composition.

4. 2. The disinfectant composition of claim 1, wherein the at least one aromatic alcohol comprises anisyl alcohol, benzyl alcohol, phenoxyethanol, vanillyl alcohol, phenols, polyphenols, derivatives thereof, or salts thereof.

5. 5. The disinfectant composition of claim 4, wherein the at least one aromatic alcohol comprises benzyl alcohol and / or phenoxyethanol and is present in an amount of about 0.01% to 50% w / w of the total composition.

6. The at least one glycol or glycol ether is ethylene glycol, propylene glycol, butylene glycol, diethylene glycol propyl ether, ethylene glycol monomethyl ether, ethylene glycol monoethyl ether, ethylene glycol monopropyl ether, ethylene glycol monoisopropyl ether, ethylene 2. The disinfectant composition of claim 1, comprising ethylene glycol monobutyl ether, diethylene glycol monomethyl ether, diethylene glycol monobutyl ether, diethylene glycol monoethyl ether, diethylene glycol mono-n-butyl ether, ethylene glycol dimethyl ether, ethylene glycol diethyl ether, ethylene glycol dibutyl ether, propylene glycol n-butyl ether, tripropylene glycol methyl ether, dipropylene glycol methyl ether, dipropylene glycol butyl ether, triethylene glycol monobutyl ether, or combinations thereof, present in an amount of about 0.01% to 50% w / w of the total composition.

7. 2. The disinfectant composition of claim 1, wherein the at least one aromatic alcohol and the at least one glycol or glycol ether are present as a blend, the blend being in a ratio of 1:100 to 100:

1.

8. 8. The disinfectant composition of claim 7, wherein the blend of at least one aromatic alcohol and at least one glycol or glycol ether is present in an amount of about 0.01% to 90% w / w of the total composition.

9. 9. The disinfectant composition of claim 8, wherein the blend of at least one aromatic alcohol and at least one glycol or glycol ether is present in an amount of about 0.1% to 75% w / w of the total composition.

10. 2. The disinfectant composition of claim 1, wherein at least one nonionic and / or anionic surfactant is present in an amount, the total amount of surfactants present being in an amount of from 0.01% w / w to 15% w / w of the total composition.

11. The disinfectant composition of claim 1, wherein at least one nonionic surfactant and / or anionic surfactant further comprises an ethoxylated fatty alcohol, a polyoxyethylene surfactant, a polyethylene glycol ester, an anhydrous sorbitol ester and its ethoxylated derivatives, a glycol ester, a carboxylic acid amide, a monoalkanolamine condensate, a polyoxyethylene fatty acid amide, or a combination thereof.

12. The disinfectant composition of claim 1, wherein at least one nonionic surfactant and / or anionic surfactant further comprises caprylyl / capryl glucoside.

13. The disinfectant composition of claim 1, wherein at least one nonionic surfactant and / or anionic surfactant further comprises an alkyl sulfate, an alkanolamide sulfate, an ethoxylated alkylphenol, or a combination thereof.

14. 10. The disinfectant composition of claim 1, wherein the at least one acid comprises an organic acid, an inorganic acid, a carboxylic acid, a mineral acid, a non-surfactant sulfonic acid, or a salt thereof.

15. 15. The disinfectant composition of claim 14, wherein the at least one acid comprises citric acid, lactic acid, glycolic acid, tartaric acid, formic acid, acetic acid, phosphoric acid, oxalic acid, propionic acid, or methanesulfonic acid.

16. The disinfectant composition of claim 14, wherein the total amount of said acids is from 0.01% to 15% w / w of the total composition.

17. 10. The disinfectant composition of claim 1, further comprising a straight or branched chain water-soluble alcohol.

18. 10. The disinfectant composition of claim 1, further comprising a peroxide stabilizer and / or chelating agent, said stabilizer and / or chelating agent being present in an amount of 0.01 w / w% to 5 w / w% based on the weight of the total composition.

19. 20. The disinfectant composition of claim 18, wherein the peroxide stabilizer and / or chelating agent comprises like phosphoric or phosphonic acids, ethylenediaminetetraacetic acid (EDTA), ethylenediamine-N,N'-disuccinic acid, 1-hydroxyethane-1,1-diphosphonic acid (HEDP) or salts thereof.

20. 10. The disinfectant composition of claim 1 having a pH of about 0 to about 5.

21. 10. The disinfectant composition of claim 1, further comprising a second biocide present in an amount of 0.01% to 40% w / w.

22. The disinfectant composition of claim 1 which is a concentrate.

23. 10. The disinfectant composition of claim 1, which is a ready-to-use composition upon dilution with an aqueous solvent, a non-aqueous solvent, or a mixture thereof.

24. 10. The disinfectant composition of claim 1, which is effective against one or more microorganisms including gram positive bacteria, gram negative bacteria, viruses, fungi, mildews, molds, or combinations thereof.

25. 25. The disinfectant composition of claim 24, wherein the microorganism comprises Staphylococcus aureus, Pseudomonas aeruginosa, Hepatitis virus, Rotavirus, Rhinovirus, Tuberculosis, or a combination thereof.

26. 26. The disinfectant composition of claim 25, which is effective against M. tuberculosis and / or M. terrae.

27. 10. The disinfectant composition of claim 1, which provides effective kill of >5 log reduction in a contact time of 5 minutes or less.

28. 30. The disinfectant composition of claim 27, providing an effective kill of >5 log reduction at a contact time of 3 minutes.

29. a) an effective amount of a hydrogen peroxide source, the hydrogen peroxide source comprising a hydrogen peroxide solution; b) at least one aromatic alcohol, the aromatic alcohol comprising benzyl alcohol and / or phenoxyethanol; c) at least one glycol or glycol ether, the glycol or glycol ether comprising diethylene glycol monobutyl ether; d) at least one nonionic and / or anionic surfactant, the surfactant comprising C １２ -C １５ Ethoxylated Alcohols, C １２ -C １４ 10. The disinfectant composition of claim 1, comprising: a surfactant comprising 70% secondary ethoxylated alcohol, 2-ethylhexanol EO-PO nonionic surfactant, caprylyl / decyl glucoside, and / or linear alkyl benzene sulfonic acid; and e) at least one acid comprising methanesulfonic acid, wherein the disinfectant composition is effective against M. tuberculosis and / or M. terrae.

30. 1. A method for disinfecting a surface from M. tuberculosis and / or M. terrae, comprising: The method comprises applying an effective amount of a disinfectant composition according to any one of claims 1 to 28 to a surface in an amount effective to kill a majority of microorganisms present on said surface.

31. 31. The method of claim 30, wherein the method comprises a disinfectant composition for inhibiting the growth of and / or reducing the number of viable microorganisms among one or more microorganisms.

32. The method of claim 30, wherein the disinfectant composition of any one of claims 1 to 28 provides a >5 log reduction in a contact time of 5 minutes or less.

33. 31. The method of claim 30, wherein the surface comprises a floor, a wall, a countertop, an appliance, a fixture, a fabric, a textile, or other hard or soft surface.

34. 1. A method for enhancing the disinfecting properties of a hydrogen peroxide source, the method comprising combining a sufficient amount of b) at least one aromatic alcohol; c) at least one glycol or glycol ether; d) at least one nonionic and / or anionic surfactant; and e) at least one acid with a hydrogen peroxide source and applying the composition to a surface, wherein the at least one nonionic and / or anionic surfactant is selected from the group consisting of C １２ -C １５ Ethoxylated Alcohols, C １２ -C １４ The method includes secondary ethoxylated alcohol 70%, 2-ethylhexanol EO-PO nonionic surfactant, caprylyl / decyl glucoside, and / or linear alkyl benzene sulfonic acid.

35. 1. A disinfectant composition comprising: b) at least one aromatic alcohol; c) at least one glycol or glycol ether; d) at least one nonionic and / or anionic surfactant; and e) at least one acid, said composition being effective against M. tuberculosis and / or M. terrae; and said composition being dilutable with a solvent to form a ready-to-use composition, said solvent comprising a source of hydrogen peroxide, and said at least one nonionic and / or anionic surfactant being at least one acid selected from the group consisting of C. tuberculosis and M. terrae; １２ -C １５ Ethoxylated Alcohols, C １２ -C １４ The disinfectant composition comprises 70% secondary ethoxylated alcohol, 2-ethylhexanol EO-PO nonionic surfactant, caprylyl / decyl glucoside, and / or linear alkyl benzene sulfonic acid.

36. 36. The disinfectant composition of claim 35, wherein the solvent further comprises an aqueous solvent, a non-aqueous solvent, or a mixture thereof.

37. 36. The disinfectant composition of claim 35, wherein the hydrogen peroxide source comprises hydrogen peroxide solution, sodium percarbonate, potassium percarbonate, sodium perborate, potassium perborate, urea hydrogen peroxide or a peroxide salt, a hydrated salt thereof, or a combination thereof.

38. 1. A two-part disinfectant comprising: a) a first container containing a biocidal amount of hydrogen peroxide and a solvent; b) at least one aromatic alcohol; c) at least one glycol or glycol ether; d) at least one nonionic and / or anionic surfactant; and e) a second container containing at least one acid, wherein the at least one nonionic and / or anionic surfactant is selected from the group consisting of C1, C2, C3, C4, C5, C6, C7, C8, C9, C10, C11, C12, C13, C14, C15, C16, C17, C18, C19, C20, C21, C31, C42, C53, C64, C75, C86, C97, C98, C107, C118, C128, C139, C22, C32, C43, C54, C65, C76, C87, C99, C119, C129, C139, C140, C150, C161, C172, C183, C194, C195, C225, C33, C44, C55, C66, C77, C88, C99, C119, C129, C230, C240, C35, C45, C56, C67, C78, ​​C89, C99, C129, C139, C240, C35, C45, C57, C68, C79, C89, C99, C140, C150, C161, C172, C183, C224, C35, C44, C55, C67, C79, C89, C99, C150, C162, C173, C184, C195 １２ -C １５ Ethoxylated Alcohols, C １２ -C １４ The two-part disinfectant comprises 70% secondary ethoxylated alcohol, 2-ethylhexanol EO-PO nonionic surfactant, caprylyl / decyl glucoside, and / or linear alkylbenzene sulfonic acid.

39. 40. The two-part disinfectant of claim 38, which is effective against M. tuberculosis and / or M. terrae and provides a >5 log reduction with a contact time of 5 minutes or less.

40. 40. The two-part disinfectant of claim 39, which provides a >5 log reduction at a contact time of 3 minutes.

41. 1. An additive for a disinfectant composition comprising: b) at least one aromatic alcohol; c) at least one glycol or glycol ether; d) at least one nonionic and / or anionic surfactant; and e) at least one acid, which enhances the disinfecting properties of the composition when combined with a disinfectant active, the disinfectant active comprising a hydrogen peroxide solution, and the at least one nonionic and / or anionic surfactant comprising at least one acid selected from the group consisting of C, C-C-D, C-D-E, C-D-E, C-E-F, C-F-G, C-G-H ... １２ -C １５ Ethoxylated Alcohols, C １２ -C １４ The additives include secondary ethoxylated alcohol 70%, 2-ethylhexanol EO-PO nonionic surfactant, caprylyl / decyl glucoside, and / or linear alkyl benzene sulfonic acid.

42. 42. The disinfectant composition additive of claim 41, wherein the disinfectant active further comprises an alcohol, a bleach, or a phenolic.

43. 42. The additive for a disinfectant composition of claim 41, wherein the hydrogen peroxide solution comprises hydrogen peroxide, sodium percarbonate, potassium percarbonate, sodium perborate, potassium perborate, urea hydrogen peroxide or a peroxide salt, a hydrated salt thereof, or a combination thereof.

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