Infection prevention and deodorizing cleaning agents, and hygiene and daily living products using them

Abstract

To provide an infection prevention and deodorant agent that makes it possible to clean a body by himself in an ordinary life, and to maintain health so as not to utilize medical organizations, and prevents intrusion of fungus, bacterium, and virus into human body, as well as, and a hygiene goods therewith.SOLUTION: An infection prevention and deodorant agent with a titanium phosphate-based compound as an effective component, in which a powdery or particulate titanium phosphate compound is dispersed in a pure aqueous solution, an electrolyte aqueous solution, a mixed solution of pure water / alcohol, or an electrolyte water / alcohol mixed solution in which at least one selected from a polysaccharide, an alkali metal salt of polysaccharide, a polymer having a quaternary ammonium base, and a surfactant having a quaternary ammonium base.SELECTED DRAWING: Figure 1

Description

[Technical field]

[0001] The present invention relates to an infection prevention and deodorizing cleaner for the purpose of "self-medication" or "personal care", as well as daily necessities, clothing, and personal items using the same. More specifically, the present invention relates to an infection prevention and deodorizing cleaner that prevents the invasion of infectious disease-causing pathogens such as fungi, bacteria, and viruses into the human body, so that the user can cleanse the body and maintain health in daily life without having to go to a medical institution, as well as daily necessities, clothing, and personal items using the same. In particular, the present invention relates to an infection-preventing and deodorizing cleaner for cleaning kitchen utensils, toilet utensils, etc., intended to prevent food poisoning, contamination, etc. caused by fungi, bacteria, and viruses, as well as sanitary products such as towels and rags using the same; an infection-preventing and deodorizing cleaner for protecting the hands, face, nose, mouth, throat, eyes, etc., intended to prevent pneumonia, influenza, etc., caused by bacteria and viruses, as well as sanitary products such as masks and eye patches using the same; an infection-preventing and deodorizing cleaner for keeping the hands, feet, and genitals clean, intended to prevent tinea and candidiasis, etc., caused by fungi and bacteria, as well as sanitary products such as gauze and absorbent cotton using the same; an infection-preventing and deodorizing cleaner for keeping the vagina and external genitalia of the internal genitalia of healthy adult female reproductive organs clean, intended to prevent vaginal infections caused by bacteria and fungi, as well as sanitary products using the same, and other infection-preventing and deodorizing cleaners that can be used in a wide range of fields, as well as daily necessities using the same. The present invention also extends to clothing and personal items in which the above-mentioned infection prevention and deodorizing cleaner, which can prevent infection and odor, is attached to underwear, socks, hats, T-shirts, sports uniforms, etc. In principle, the names of products in this invention are based on the Japanese Design Classification (effective May 1, 2019), but are not strictly classified. [Background technology]

[0002] In developed countries, once people's material desires are satisfied, they begin to demand a clean and healthy living environment, that is, a living environment protected from invisible fungi, bacteria, and viruses, and nowadays, it is not uncommon to see antibacterial products that claim to be antibacterial, such as household and kitchen utensils, food containers and packaging materials, clothing, stationery and toys, electrical and electronic products, housing and building materials, vehicles and aircraft. In particular, due to the spread of coronavirus infection, disinfectants such as electrolytic water and alcohol that have antifungal, antibacterial, and antiviral activity are now installed at the entrances and exits of not only public facilities such as hospitals and schools, but also general stores and business establishments (for example, Non-Patent Documents 1 and 2). In this specification, "antibacterial" means to suppress or prevent the growth of fungi and bacteria, or to kill or damage them, and "antiviral" means to inactivate viruses.

[0003] Food is an essential part of daily human life, and ensuring food safety is an extremely important issue. Even now, outbreaks of food poisoning caused by norovirus, Salmonella, enterohemorrhagic Escherichia coli such as O157, and other such bacteria occur frequently in the summer (bacteria) and winter (viruses), and there is still a continuing need for sanitary products to prevent this (e.g., Non-Patent Document 2).

[0004] Furthermore, food in developed countries has the problem of excessive distribution and surplus of materially rich foods, that is, foods with expiration dates and expiration dates cannot be reused like durable consumer goods such as home appliances, furniture, and automobiles, and semi-durable consumer goods such as clothing and bags, and about 1.3 billion tons of food, which is one-third of the world's production, and about 17 million tons of food waste per year in Japan, are discarded without being touched. In particular, foods with short expiration dates such as bento and salads are discarded as they are if they are not sold, and a large amount of edible food is lost almost every day, so food waste can be significantly reduced even by extending the expiration date by just one day. From this perspective, it is also necessary to protect food from fungi and bacteria (for example, Non-Patent Document 3).

[0005] On the other hand, working women today are experiencing more severe physical and immune declines due to overwork and stress, as well as more severe imbalances in female hormones (e.g., decreased estrogen secretion), and are therefore facing problems with vaginal infections, which are endogenous infections caused by the disruption of the balance of bacterial flora present in the vagina, or iatrogenic infections that arise as a result of medical procedures. There is a demand for infection-preventing and deodorizing cleansers that can prevent these infections without the need to visit a medical institution, keep the internal vagina and external genitalia clean, and also give a feeling of cleanliness.

[0006] Until now, antibacterial products have meant woven fabrics and various molded products made of fibers and plastics to which organic or inorganic antibacterial agents are fixed, which are used everywhere, such as household and kitchen utensils, food containers and packaging materials, clothing, stationery and toys, electrical and electronic products, housing and building materials, vehicles and aircraft (e.g., Non-Patent Documents 1 and 2).

[0007] However, recently, due to the influence of the spread of coronavirus infection, a large number of sanitary products, such as hanging or stationary sanitary products that utilize the antibacterial and antiviral activities of chlorine dioxide, sanitary products that directly spray hypochlorous acid water, slightly acidic electrolyzed water, alcohol, and liquids in which inorganic or organic antibacterial agents are dispersed or dissolved, and sanitary products such as masks, diapers, tissues, napkins, and panty liners that have woven fabrics, nonwoven fabrics, absorbent cotton, gauze, etc. soaked in hypochlorous acid water, slightly acidic electrolyzed water, alcohol, and liquids in which inorganic or organic antibacterial agents are dispersed or dissolved, have been sold on the market (for example, Patent Documents 1 to 3 and Non-Patent Document 4).

[0008] On the other hand, to prevent tinea and vaginal infections caused by fungi and bacteria, it is still necessary to acquire the habit of keeping the body, home environment, and genitals clean in daily life. However, rather than prevention, infection has often been treated with local and oral therapy using antifungal agents or antibiotics (e.g., Non-Patent Documents 5 and 6).

[0009] However, antibiotic vaginal tablets such as chloramphenicol, or antimicrobial vaginal tablets such as metronidazole or clindamycin cream, which are inserted into the vagina for local treatment of vaginal infection, reduce the activity of Döderlein's bacillus and may cause side effects such as skin symptoms such as rash, itching, redness, irritation, and erosion, as well as shock and anaphylaxis (dyspnea, generalized flushing, angioedema, urticaria, etc.). In addition, washing the vagina with sterile distilled water, saline, benzalkonium chloride solution, or povidone-iodine solution to enhance the therapeutic effect may result in significant interference with the self-cleaning function of the vagina, as it excretes Döderlein's bacillus.

[0010] And, the antimicrobial agent metronidazole tablets, or the penicillin antibiotics ampicillin capsules or amoxicillin capsules used in the oral therapy of vaginal infections are not established, and in particular, metronidazole tablets have side effects such as diarrhea, rash, tongue coating, loss of appetite, stomach discomfort, abnormal taste, peripheral neuropathy, central nervous system disorder, aseptic meningitis, etc., and are prohibited from being administered to pregnant women. Penicillin antibiotics have side effects such as rash, itching, fever, diarrhea, loose stools, nausea, vomiting, loss of appetite, abdominal pain, abnormal taste, liver damage, and kidney damage, and also cause a decrease in the activity of Doderlein's bacillus.

[0011] Therefore, particularly for vaginal infections, preventive measures such as oral preparations of lactic acid bacteria, vaginal preparations containing lactic acid oligomers, and vaginal cleansers containing lactic acid, as well as sanitary products for cleaning the vagina and external genitalia of the female reproductive system, have been provided (e.g., Patent Documents 4 to 6 and Non-Patent Document 7).

[0012] First, vaginal infection is a dangerous disease, as described below, and is a problem that cannot be ignored in today's society with a declining birthrate, and this problem is thought to be avoided. When bacteria that grow in vaginal infection pass through the cervix, it can cause endometritis, salpingitis, pelvic peritonitis, etc. These pelvic inflammatory diseases are dangerous infections that are accompanied not only by inflammation, lower abdominal pain, fever, vomiting, and adhesion of organs, but also lead to aftereffects such as infertility, ectopic pregnancy, and chronic pelvic pain. When a pregnant woman suffers from bacterial vaginosis, it causes chorionitis and the associated puerperal endometritis, which are thought to be the cause of miscarriage, premature birth, and low birth weight babies, and when the fetus is infected, it can cause not only neonatal pneumonia, meningitis, bacteremia, and sepsis, but also periventricular leukomalacia and chronic lung disease. Thus, even though vaginal infections are asymptomatic, they are dangerous diseases that further reduce birth rates and have adverse effects on offspring, and so there is a growing awareness that it is necessary to take great care on a daily basis (e.g., non-patent documents 5 and 6).

[0013] Secondly, the above preventive measures aim to improve the vaginal environment (for example, Patent Documents 4 to 6 and Non-Patent Documents 5 to 7). In the vagina of a healthy woman, the presence of Döderlein's bacillus (discovered by German obstetrician A. Döderlein), which accounts for 75 to 95% of the vaginal flora, breaks down glycogen exfoliated and shed from the surface of the vaginal epithelial cells to produce lactic acid, which maintains a strong acidity of pH = 3.5 to 4.5, preventing the proliferation of fungi and bacteria, and when a normal balance of the vaginal flora is maintained, the woman will not suffer from vaginal infections. The causes of the destruction of this normal balance of vaginal flora are the decrease in the amount and activity of Döderlein's bacillus and the amount of glycogen shed from the surface of vaginal epithelial cells due to the decrease in physical strength and immunity caused by overwork and stress, and the imbalance of female hormones (e.g., the decrease in estrogen secretion), as well as the adverse effects on the self-cleaning function caused by the overuse of antibiotics, the regulation of menstruation, vaginal douching, the use of intrauterine contraceptive devices (IUDs), etc. In other words, the above preventive measures are intended to protect the vaginal flora mechanism from destruction caused by these causes and to improve the vaginal environment.

[0014] Meanwhile, in recent years, deodorizers for clothes, curtains, etc. have become necessities in daily life. However, in the current age of the threat of viral infections, there is a strong demand for cleaning agents that not only have a deodorizing effect but also have an infection prevention effect that is safe for the human body for daily necessities such as curtains, rugs, and bedding, as well as clothing and personal items such as underwear, socks, hats, T-shirts, and sports uniforms.

[0015] As described above, attention has been drawn to infection prevention and deodorizing cleaners and hygiene products using the same for the purpose of "self-medication" or "personal care", or more broadly, to infection prevention and deodorizing cleaners and daily necessities, clothing, and personal items using the same that prevent the invasion of infectious disease-causing pathogens such as fungi, bacteria, and viruses into the human body in order to keep the body clean and healthy in daily life without having to go to a medical institution. However, no infection prevention and deodorizing cleaner has been found that has activity against various microorganisms such as fungi, bacteria, and viruses, as well as a deodorizing function, is sufficiently effective, can be used safely, and is applicable to a wide range of daily necessities, clothing, and personal items.

[0016] For example, there are many hanging and stationary air purifiers on the market that utilize the disinfecting and sterilizing action and deodorizing function of chlorine dioxide as described in Patent Documents 1 and 2 to disinfect and sterilize viruses and bacteria floating in the air, and to deodorize. However, there are problems with the hanging type, such as skin chemical fever, reported when wearing the hanging type. In addition, stationary types have problems such as the strong chlorine odor and cannot stay in the room where they are installed, the problem that chlorine dioxide may corrode metals, and therefore cannot be placed near electrical appliances and metal products, and the possibility that contact with chlorine dioxide is harmful to the human body cannot be denied. Therefore, chlorine dioxide water cannot be applied to sanitary products such as masks, diapers, tissues, napkins, and panty liners that are soaked in woven fabric, nonwoven fabric, absorbent cotton, gauze, etc.

[0017] There is a report of a wet towel containing a liquid in which an organic antibacterial agent, which is believed to be polyhexamethylene biguanide hydrochloride, a cationic surfactant described in Non-Patent Document 4, is dissolved. This is an improvement over the toxicity and drug-resistant bacteria production problems of conventional wet towels containing triclosan and oxacillin, and although there is a description of activity against bacteria, there is no description of activity against viruses. In addition, there are problems with thermal stability, which is well known for organic antibacterial agents, and chemical stability against light, water, air, etc., as well as safety issues for the human body. As for the safety issue, particular attention must be paid to the fact that there is no chemical bond between the organic antibacterial agent and the woven or nonwoven fabric of the wet towel, and therefore it is possible that the organic antibacterial agent will leak into the human body.

[0018] As an organic antibacterial agent that has improved the problem of such organic antibacterial agent leakage, a silicon compound having a quaternary ammonium salt and an alkoxysilane having antibacterial and antiviral activity has been developed as described in Patent Document 3, and there have been reports of wet tissues using this compound. However, this does not solve the other problems of the organic antibacterial agents mentioned above.

[0019] In addition, there are sanitary products that contain silver particles and alcohol, which are typical examples of inorganic antibacterial agents, but they have no activity against viruses and cannot be applied to a wide range of daily necessities, including those that are effective against influenza, norovirus, etc.

[0020] Regarding vaginal infections, oral agents, vaginal agents, and vaginal washes that improve the vaginal environment have been reported.

[0021] As described in Non-Patent Document 7, oral preparations for improving the vaginal environment include tablets containing lactic acid bacteria, Lactobacillus rhamnosus and Lactobacillus helveticus, which act in the same way as bifidobacteria for improving the intestinal environment, and help increase Doderlein's bacillus to improve the vaginal environment. However, while the optimal pH for growth of lactic acid bacteria is said to be in the range of 5.0 to 8.0, the pH of the lactic acid produced by Doderlein's bacillus is strongly acidic at 3.5 to 4.5, and it has been reported that lactic acid bacteria other than Lactobacillus acidophilus cannot survive in such a strongly acidic environment (e.g., Non-Patent Document 8). Therefore, this is considered to indicate an essential problem in administering lactic acid bacteria.

[0022] A pharmaceutical composition consisting of a lactic acid oligomer and a mucoadhesive has been proposed as a vaginal preparation for improving the vaginal environment (Patent Document 4). It is described that this is effective by releasing lactic acid from the lactic acid oligomer over time, and it is likely that the lactic acid oligomer releases lactic acid by hydrolysis in an acidic environment. However, the hydrolysis does not occur in the lactic acid monomer units that constitute the lactic acid oligomer, and the final product is not necessarily lactic acid. Even if the final product becomes lactic acid, it is thought to have a long life. As for the form of sanitary products, creams, liquids, soaps, tablets, etc., as well as a method of soaking a tampon and inserting it into the vagina, and a method of injecting it into the vagina with a syringe, etc. are described.

[0023] On the other hand, a vaginal cleanser with activated carbon dispersed therein has been proposed as a vaginal cleanser for improving the vaginal environment, and a method has been described in which the cleanser is soaked into gauze, cotton balls, tampons, etc. and inserted into the vagina (Patent Document 5). However, although activated carbon has an excellent function of absorbing odors, which are low molecular weight substances, the ability of activated carbon to absorb fungi and bacteria is limited, and the fungi and bacteria that can be absorbed are also limited (Non-Patent Document 9). In addition, no study has been conducted on the adsorption of viruses.

[0024] Furthermore, an internal cavity injection tool that is presumed to be used for injecting a cleansing agent into the vagina has been disclosed, which is characterized in that it comprises an instrument body having a filling space for filling the internal space of a cylindrical pipe-shaped insert with a liquid agent, and a delivery rod for delivering the liquid agent from the injection hole, and that a sealing plug integrally connected to a detachable operation piece attached to the injection hole vacuum-seals the filling space, and that a partition piece that allows the liquid agent to move only toward the injection hole when the vacuum-sealed state is released by operating the detachable operation piece is interposed between the filling space and the delivery rod (Patent Document 6).The liquid agent contains lactic acid as a pH adjuster, and is considered to be a cleansing gel that is gentle on the vaginal environment, as it is adapted to the vagina, which is kept at a strong acidity of pH = 3.5 to 4.5 by lactic acid produced by Doderlein's bacillus (Non-Patent Document 10). Although the amount of liquid used is small, it is the same as washing with sterile distilled water or saline solution, in that it expels and removes dirt, menstrual residue, and odors from the vaginal opening, and there are concerns that it may have a negative impact on the self-cleaning function of vaginal washes.

[0025] As described above, in daily life, infection prevention agents and deodorant cleaners that can be applied to "self-medication" or "personal care" to keep one's body clean and healthy and prevent the invasion of infectious pathogens such as fungi, bacteria, and viruses into the human body vary in the fields of sanitary products, baby products, nursing care products, and sanitary products, and there are no infection prevention and deodorant cleaners that can be commonly applied across a wide range of fields, and their properties are also different. Accordingly, countless infection prevention and deodorant cleaners in different forms and sanitary products using them are being produced in large quantities. In addition, if there is an infection prevention and deodorant cleaner that has all of the following activities, antifungal activity, antibacterial activity, antiviral activity, and deodorant activity, it would be possible to impart infection prevention and deodorant effects to daily necessities such as curtains, rugs, and bedding, and clothing and personal items such as underwear, socks, hats, T-shirts, and sports uniforms, simply by spraying it. [Prior art documents] [Patent documents]

[0026] [Patent Document 1] Patent No. 6586652 [Patent Document 2] Patent No. 5593423 [Patent Document 3] International Publication No. 2010 / 073825 [Patent Document 4] Special Publication No. 2015-526413 [Patent Document 5] JP 2009-96755 A [Patent Document 6] JP 2018-57574 A [Patent Document 7] Patent No. 3829640 [Patent Document 8] Patent No. 4430877 [Non-patent literature]

[0027] [Non-Patent Document 1] Yasushi Kikuchi, "Current status and problems of antibacterial metallic materials", Materia, Vol. 39 (2000), No. 2, pp. 146-150 [Non-Patent Document 2] Keiichiro Hiyama, "Antibacterial Treatment of Plastic Products", Journal of the Society of Textile Products Consumption Science, Vol. 40, No. 9, pp. 576-584 (1999) [Non-Patent Document 3] Ministry of Agriculture, Forestry and Fisheries (Food Industry Bureau, Biomass Environmental Resources Division, Food Industry Environmental Measures Office), "Toward Food Loss Reduction ~Let's get back the 'Mottainai' spirit!~", September 2013, [online], [Retrieved November 21, 2020], Internet,<https: / / www.maff.go.jp / Kinki / syouhi / mn / iken / attach / pdf / 30nendo-8.pdf> [Non-Patent Document 4] Takumi Kajiura, "The 3rd Tokyo Health Care University Graduate School Overseas Conference," Healthcare-associated Infection, Vol. 4, No. 2, December 2011, pp. 116-118 [Non-Patent Document 5] Hiroshi Tsutsumi, "I. Bacterial Infections, 10 Bacteria encountered in cytological examinations in gynecology, urology, and ophthalmology", Atlas of Infectious Disease Pathology, pp.38-41, [online], [Retrieved November 22, 2020], Internet,<https: / / pathos223.com / atlas / pdf10.pdf> [Non-Patent Document 6] Japanese Society for Sexually Transmitted Diseases, "Part 2 Disease-specific Diagnosis and Treatment, 8. Bacterial Vaginosis", Sexually Transmitted Diseases Diagnosis and Treatment Guidelines - 2008 Edition, Japanese Society for Sexually Transmitted Diseases, Vol. 19, No. 1, Suppl., 2008, pp. 77-80, [online], [Retrieved November 22, 2020], Internet,<http: / / jssti.umin.jp / pdf / guideline2008 / 02-8.pdf> [Non-Patent Document 7] Taiho Pharmaceutical Co., Ltd., "Ingredients that support the increase of good bacteria (Döderlein's bacillus) in the vagina", [online], [Retrieved November 22, 2020], Internet,<https: / / rosell1152.jp / 02 / > [Non-Patent Document 8] Fumio Yamada, Katsuma Ueda, Haruyoshi Nagata, Hiroshi Kaji, Koji Kurozumi, Toru Hamada, "Experience of using live Doderlein vaginal capsules for various vaginitis", Progress in Obstetrics and Gynecology, Vol. 21, No. 2, pp. 141(61)-145(65), 1969, [online], [Retrieved November 22, 2020], Internet,<https: / / www.jstage.jst.go.jp / article / sanpunosinpo1949 / 21 / 2 / 21_2_141 / _pdf> [Non-Patent Document 9] Kim, Ju-young, Sugiura, Norio, Fushimi, Satoshi, Inamori, Yuhei, Nishimura, Osamu, Sudo, Ryuichi, "Bacterial adhesion ability and high-concentration substrate decomposition characteristics on biological activated carbon", Journal of the Japanese Society of Water Treatment Biology, Vol. 30, No. 1, pp. 49-56 (1994) [Non-Patent Document 10] Hanamisui Co., Ltd., "Inclear", [online], [searched on November 23, 2020], Internet,<https: / / hanamisui.jp / inclear / > [Non-Patent Document 11] Nobuyuki Kato, "Antibacterial Action of Alcohols," Konan Women's University Research Bulletin (15), pp.189-198, 1978, [online], [Retrieved November 23, 2020], Internet,<https: / / konan-wu.repo.nii.ac.jp / > [Non-Patent Document 12] Takeaki Iida, Kazuhiko Yamaoka, Seiji Nojiri, Hiroshi Nozaki, "Crystallization process of titanium oxide by hydrolysis of titanium tetrachloride and its physical properties", Journal of Industrial Chemistry, Vol. 69, No. 11, 1966, pp. 2087-2095 [Non-Patent Document 13] Hiroshi Konan, Fumiaki Otani, "Introduction to electrochemical measurement - Basics and know-how on photocatalytic adjustment methods", Electrochemistry and industrial physical chemistry (DENKI KAGAKU), 1998, Vol. 66, No. 10, pp. 996-1003 [Non-Patent Document 14] Takashi Saji, "Generation, Properties and Applications of Condensed Phosphoric Acid", Journal of Industrial Chemistry, 1963, Vol. 66, No. 5, pp. 528-537 [Non-Patent Document 15] Toyosuke Tanaka, "Chemistry of Organoboron Compounds", Organic Synthesis Chemistry, Vol. 22, No. 10, 1964, pp. 806-815 [Non-Patent Document 16] Tokuo Fukuda, "Polylactic acid gel", [online], [searched November 30, 2020], Internet,<http: / / www.aichi-inst.jp / other / up_docs / z_no06_04.pdf> [Non-Patent Document 17] Ayaka Fujita, "Development of a new biodegradable superabsorbent polymer and its performance evaluation", [online], [Retrieved November 30, 2020], Internet,<http: / / www.fbi-award.jp / sentan / jusyou / 2011 / 4.pdf> [Non-Patent Document 18] Yuichi Oya, Koji Nagahama, "Biodegradable polymer materials", Drug Delivery System, 2008, Vol. 23, No. 6, pp. 618-626 Summary of the Invention [Problem to be solved by the invention]

[0028] As explained in the background art, conventionally, different infection prevention and deodorizing cleaners are needed for different purposes, such as infection prevention and deodorizing cleaners for cleaning kitchen utensils and toilet utensils, etc., intended to prevent food poisoning and contamination, etc., caused by fungi, bacteria, and viruses; infection prevention and deodorizing cleaners for protecting the hands, face, nose, mouth, throat, etc., intended to prevent pneumonia, influenza, etc., caused by bacteria and viruses; infection prevention and deodorizing cleaners for keeping the hands, feet, and genitals clean, intended to prevent tinea and candidiasis, etc., caused by fungi and bacteria; and infection prevention and deodorizing cleaners for keeping the vagina and external genitalia of the internal genital organs of healthy adult female reproductive organs clean, intended to prevent vaginal infections caused by bacteria and fungi. For this reason, infection prevention agents and deodorant cleaners that can be used in daily life as "self-medication" or "personal care" to keep oneself healthy by keeping one's body clean and taking care of it, and that prevent the invasion of infectious disease-causing pathogens such as fungi, bacteria, and viruses into the human body, vary not only in substance but also in properties in areas such as sanitary products, baby products, nursing care products, and menstrual products, and countless hygiene products in different forms continue to be produced in large quantities.

[0029] The excessive production of such numerous sanitary products is wasteful, increases product costs, and is an obstacle to consumers' continuous long-term use of "self-medication" or "personal care" in their daily lives. However, if there are infection prevention agents and deodorant cleansers with substances and properties common to the above fields and can be stored at home, they can be sprayed on hands and feet, or impregnated with an appropriate amount into masks, diapers, tissues, socks, bandages, napkins, panty liners, tampons, etc., and used to prevent infection by various fungi, bacteria, and viruses. They can also be impregnated into woven fabrics, nonwoven fabrics, absorbent cotton, gauze, etc. of a material and shape suitable for the method of use, and pasted together with masks, diapers, socks, bandages, napkins, panty liners, etc. for appropriate use. In addition, they can be fully absorbed into tampons and used as vaginal cleansing products as a countermeasure against vaginal infections. Furthermore, infection prevention and deodorizing effects can be imparted to everyday items such as curtains, rugs, and bedding, as well as clothing and personal items such as underwear, socks, hats, T-shirts, and sports uniforms, simply by spraying the product, making it possible to continue ``self-medication'' or ``personal care'' that is closely related to daily life over a long period of time.

[0030] That is, the present invention aims to provide an infection-preventing and deodorizing cleaner that has a preventive effect for any of the following purposes and can be commonly used: an infection-preventing and deodorizing cleaner for cleaning kitchen utensils, toilet utensils, etc., intended to prevent food poisoning, contamination, etc., caused by fungi, bacteria, and viruses; an infection-preventing and deodorizing cleaner for protecting the hands, face, nose, mouth, throat, etc., intended to prevent pneumonia, influenza, etc., caused by bacteria and viruses; an infection-preventing and deodorizing cleaner for keeping the hands, feet, and genitals clean, intended to prevent tinea and candidiasis, etc., caused by fungi and bacteria; and an infection-preventing and deodorizing cleaner for keeping the vagina and external genitalia of the internal genital organs of healthy adult female reproductive organs clean, intended to prevent vaginal infections caused by bacteria and fungi. The aim is to provide cleaning and hygiene products such as sanitary products, baby products, nursing care products, and sanitary products that use the infection prevention and deodorizing detergent, as well as daily necessities including curtains, rugs, and bedding, as well as clothing and personal items such as underwear, socks, hats, T-shirts, and sports uniforms. [Means for solving the problem]

[0031] The inventor recognized that titanium phosphate-based compounds have antifungal and antibacterial activity against fungi and bacteria, and also have deodorizing activity to suppress odors (e.g., Patent Documents 7 and 8). Furthermore, the inventor discovered that a dispersion in which titanium phosphate-based compounds are forcibly dispersed in pure water as particles, rather than being used as a film, has an even higher antibacterial activity and an antiviral activity that kills various viruses, leading to the present invention. The reason for such increased antibacterial and antiviral activity is unclear, but it is believed to be due to the microparticulation effect, i.e., the specific surface area of ​​titanium phosphate-based compound particles is significantly increased compared to the specific surface area of ​​the titanium phosphate-based compound film.

[0032] That is, the present invention relates to an infection-preventing and deodorizing cleaning agent characterized in that titanium phosphate compound particles are dispersed in pure water or electrolytic water.

[0033] The pure water may be any of the well-known ion-exchanged water, distilled water, reverse osmosis water, and elixirs pure water, but distilled water, reverse osmosis water, and elixirs pure water that do not contain organic substances are preferable, and from an economical standpoint, distilled water is more preferable.

[0034] Electrolyzed water is not strong acidity or strong alkalinity, is excellent in safety, and is preferably any of weak acidity electrolyzed water, slightly acidity electrolyzed water, and electrolyzed hypochlorous water, which are approved as food additives, and is more preferably slightly acidity electrolyzed water, which is hypochlorous acid water, which has activity against the widest range of fungi, bacteria, and viruses.Therefore, the electrolyzed water dispersion of titanium phosphate compound particles has better antibacterial and antiviral activity than the pure water dispersion of titanium phosphate compound particles, because electrolyzed water has activity against fungi, bacteria, and viruses that pure water does not have, and because it exhibits a synergistic effect between titanium phosphate compound particles and electrolyzed water.

[0035] The cleaning agent of the present invention preferably further contains a water-soluble alcohol, which, like electrolytic water, exerts a synergistic effect with the titanium phosphate compound particles and enhances the antibacterial properties. Examples of such alcohol include methanol, ethanol, 1-propanol, 1-butanol, and 1-pentanol.

[0036] In particular, the water-soluble alcohols of methanol, ethanol, and 1-propanol are generally used because the alcohol aqueous solution concentration at which antibacterial properties are exhibited in a short time is about 70% by weight (in the case of ethanol), which is considered to be a concentration at which a large amount of alcohol clusters exhibiting antibacterial properties are formed. However, when the alcohol concentration is about 8-20% by weight, about 20-40% by weight, about 40-80% by weight, and about 80-100% by weight, it has been reported that the time until bacteria are killed is about 30 minutes to 48 hours, about 10 minutes to 30 minutes, within about 5 minutes, and about 10 minutes to 30 minutes, respectively, but it is effective after a long contact treatment, and titanium phosphate-based compound particles are also included, so it is preferable to appropriately determine the concentration according to the application.

[0037] On the other hand, it has been reported that the antibacterial effect of alcohol increases with an increase in the number of carbon atoms (Non-Patent Document 11), but in the present invention, it was found that even if a small amount of alcohol with low solubility in water is added, it has an effect equal to or greater than that of the above-mentioned water-soluble alcohol. 1-butanol, which has a solubility in water of about 6 g, and 1-pentanol, which has a solubility in water of about 2 g, are preferred, and it is particularly preferred to add them in amounts of about 6% by weight and about 2% by weight, respectively, of the solvent.

[0038] The infection prevention and deodorant cleaner obtained by dispersing titanium phosphate compound particles in such pure water or electrolytic water, or pure water or electrolytic water containing alcohol, has antifungal activity, antibacterial activity, and antiviral activity, and can be used to prevent various fungal, bacterial, and viral infections by spraying it on hands and feet, or by soaking a mask, diaper, tissue, socks, bandage, napkin, panty liner, tampon, etc. in an appropriate amount. In addition, this cleaner can be soaked into woven fabric, nonwoven fabric, absorbent cotton, gauze, etc. of a material and shape suitable for the method of use, and then pasted together with a mask, diaper, socks, bandage, napkin, panty liner, etc. for appropriate use. Furthermore, it can be fully absorbed into a tampon and used as a vaginal cleansing product as a countermeasure against vaginal infections.

[0039] In this way, the infection prevention and deodorizing cleaner of the present invention is used, and in order for the titanium phosphate compound particles to maintain dispersion stability in the cleaner for a long period of time, it is preferable that polysaccharides and / or alkali metal salts of polysaccharides are contained as dispersants. In addition, polysaccharides and / or alkali metal salts of polysaccharides not only function as dispersants for titanium phosphate compound particles, but also can adjust the viscosity to an appropriate level according to the application of the cleaner, and firmly attach the titanium phosphate compound particles to hands and feet, woven fabrics, nonwoven fabrics, absorbent cotton, gauze, etc., and maintain the infection prevention and deodorizing functions for a long period of time. In addition, the infection prevention and deodorizing functions are spread not only on such sanitary products, but also on daily necessities including curtains, rugs, bedding, etc., and on clothes and personal items such as underwear, socks, hats, T-shirts, and sports uniforms, and exhibit the infection prevention and deodorizing functions for a long period of time.

[0040] In particular, it is preferable that the composition contains at least one selected from cellulose derivatives, microcrystalline cellulose, gum arabic, alginic acid, alginic acid derivatives, guar gum, tara gum, locust bean gum, carrageenan, karaya gum, xanthan gum, gellan gum, succinoglycan, tamarind seed gum, pectin, agar, glucomannan, starch, and modified starch polysaccharides, as well as cellulose derivatives, gum arabic, alginic acid, alginic acid derivatives, carrageenan, karaya gum, xanthan gum, gellan gum, succinoglycan, agar, and modified starch alkali metal salts. Since the dispersion stability and viscosity vary depending on the type, molecular weight, and modification amount of the polysaccharide and / or the alkali metal salt of the polysaccharide used, it is preferable to determine them appropriately depending on the application, but from the viewpoint of the dispersion stability of the titanium phosphate compound particles of the infection prevention and deodorant and the impregnation into the above-mentioned various absorbents, it is preferable to contain about 0.1 to 30% by weight of the solvent.

[0041] It is even more preferable that the composition contains a polymer and / or a surfactant having a quaternary ammonium base that has the same function as the polysaccharide and / or the alkali metal salt of the polysaccharide and further has antifungal activity, antibacterial activity, and antiviral activity.

[0042] In particular, from the viewpoint of dispersion stability, it is preferable that the polymer having a quaternary ammonium salt group is one or more selected from an acrylic polymer having a quaternary ammonium salt, a vinyl polymer having a quaternary ammonium salt, and a polysaccharide derivative having a quaternary ammonium salt, and the surfactant having a quaternary ammonium salt is a saturated hydrocarbon compound having a quaternary ammonium salt and / or a polyalkylene glycol having a quaternary ammonium salt. In the case of such a polymer having a quaternary ammonium salt and a surfactant, it is preferable that the content of the surfactant is about 0.1 to 30% by weight of the solvent from the same viewpoint.

[0043] Among these, in order to obtain dispersion stability, adjust viscosity, and allow titanium phosphate compound particles to adhere firmly to hands and feet, woven fabric, nonwoven fabric, absorbent cotton, gauze, etc., while maintaining a moisturizing state that is gentle on the skin for a long period of time, and to retain infection prevention function, it is most preferable that the compound having a quaternary ammonium salt is polyvinyl alcohol, guar hydroxypropyltrimonium chloride, or hydroxypropyltrimonium hyaluronate having a quaternary ammonium salt.

[0044] When using the above-mentioned quaternary ammonium salt compound, particularly a surfactant having a quaternary ammonium salt, it is preferable that a polysaccharide is further contained in order to set a wide range of viscosity, and polysaccharides that do not have an anionic functional group and are not ionically crosslinked with the quaternary ammonium salt, such as alkyl cellulose, hydroxyalkyl cellulose, hydroxyethyl cellulose, microcrystalline cellulose, guar gum, tara gum, locust bean gum, tamarind seed gum, pectin, glucomannan, and starch, are suitable. In the case of polysaccharides having an anionic functional group, when mixed with a quaternary ammonium compound, gelation may occur, making it difficult to use. In this case, the amount of polysaccharide added is preferably about 0.1 to 30% by weight of the solvent from the viewpoint of impregnation into the various absorbents.

[0045] In particular, when the agent is absorbed into a napkin, panty liner, or tampon and used as an external or internal vaginal cleansing product, it is preferable that the infection prevention and deodorant cleanser contains lactic acid at about 0.1 to 9.0% by weight in order to adjust the pH to 3.5 to 4.5, which is the acidity in the vagina maintained by lactic acid produced by Doderlein's bacillus. This makes the infection prevention and deodorant cleanser suitable for the female genital organs. Since the infection prevention and deodorant of the present invention is not applied to infected persons, it is preferable to wash the vaginal cavity in a manner that does not destroy the balance of the vaginal bacterial flora due to excessive washing. It is preferable to insert a tampon that has been sufficiently absorbed with the cleanser of the present invention once a week for a day and night, but since there are individual differences, it is preferable to wash according to the situation.

[0046] On the other hand, titanium phosphate compound particles have the chemical formula Ti(OH) x (PO 4 ) y (HPO 4 ) z (H 2 PO 4 ) m (OR) n (R is an alkyl group having 1 to 4 carbon atoms, and x, y, z, m, and n are each a number of 0 or more. x≧1, y+z+m≧1, and The titanium phosphate compound particles are characterized by being composed of a titanium phosphate compound represented by the formula (x+3y+2z+m+n=4). The required amount of such titanium phosphate compound particles varies depending on various factors such as the application and the method of use, but in order to exhibit antibacterial activity and antiviral activity, at least 0.001 to 30% by weight is required relative to the dispersion medium containing the various additives described above. To be more effective, the amount is more preferably 0.01 to 30% by weight, and even more preferably 0.1 to 30% by weight.

[0047] The titanium phosphate compound particles are Ti(OH) x (PO 4 ) y (HPO 4 ) z (H 2 PO 4 )m (OR) n (R is an alkyl group having 1 to 4 carbon atoms, and x, y, z, m, and n are each a number of 0 or more. x≧1, y+z+m≧1, and In order to produce particles made of a titanium phosphate-based compound represented by the formula (satisfying x+3y+2z+m+n=4), a method of reacting titanium tetrachloride with a mixed solvent of water and an alcohol having 1 to 4 carbon atoms and then reacting it with phosphoric acid is preferred, but the method is not limited to this.

[0048] Titanium phosphate compound particles inherently have antibacterial activity, antiviral activity, and deodorizing activity, but in order to further enhance the deodorizing activity, it is preferable to mix at least one of titanium silicate compound particles and titanium borate compound particles.

[0049] In particular, from the viewpoint of deodorizing activity, the titanium silicate compound particles are preferably made of a titanium silicate compound prepared by reacting silicon tetrachloride with water or alcohol, or a mixed solution of water and alcohol, and then adding titanium tetrachloride to the resulting reaction solution and reacting it, and the chemical composition of the titanium silicate compound is preferably TiO 2 SiO 2 Similarly, the titanium borate compound particles are preferably made of a titanium borate compound prepared by dissolving boric acid in water or alcohol, or a mixed solution of water and alcohol, and adding titanium tetrachloride to the resulting boric acid solution to cause a reaction, and the chemical composition of the titanium borate compound is preferably TiO 2 ·B 2 O 3 It is more preferable that:

[0050] The mixing ratio of the titanium phosphate compound particles and the titanium silicate compound particles and / or the titanium borate compound particles is preferably in the range of 100:50 to 100:10 by weight in order to significantly exhibit the deodorizing effect of the titanium silicate compound particles and / or the titanium borate compound particles, but it is not necessary to mix the titanium silicate compound particles and / or the titanium borate compound particles, as they are mixed appropriately according to the use of the infection prevention and deodorizing cleaning agent. In addition, when both the titanium silicate compound particles and the titanium borate compound particles are mixed, the mixing ratio of these is preferably 100:10 to 100:50 by weight in order to enhance the deodorizing effect.

[0051] As already explained, the titanium phosphate-based compound particles, titanium silicate-based compound particles, and titanium borate-based compound particles used in the infection prevention and deodorant cleaning agent of the present invention are characterized by being dispersed in an aqueous dispersion medium as particles and used, and the antibacterial activity, antiviral activity, and deodorant activity are significantly improved. This is similar to the idea that the specificity of nanoparticles is partly due to the size of the specific surface area associated with the miniaturization of the particle diameter, and is due to the fact that the specific surface area is larger when the form of these compounds is particulate than when they are film-like. Therefore, the smaller the average particle diameter of these compound particles, the more difficult it is to disperse them into primary particles, and once dispersed into primary particles, the more agglomerates are generated, and the dispersion stability is poor. For this reason, the above-mentioned polysaccharides and / or alkali metal salts of polysaccharides, or polymers and / or surfactants having quaternary ammonium bases are contained, and the average particle size of the titanium phosphate-based compound particles, titanium silicate-based compound particles, and titanium borate-based compound particles is preferably 5 to 100 nm, more preferably 10 to 90 nm, and even more preferably 20 to 80 nm.

[0052] Next, a method for producing titanium phosphate-based compound particles having such antifungal activity, antibacterial activity, antiviral activity, and deodorizing activity, in particular titanium silicate-based compound particles and titanium borate-based compound particles having excellent deodorizing activity, will be described.

[0053] First, titanium phosphate-based compounds are produced using titanium tetrachloride and phosphoric acid as main raw materials through a first step of mixing titanium tetrachloride with a mixed solution of water and an aliphatic alcohol having 1 to 4 carbon atoms to cause a reaction, a second step of adding phosphoric acid to the reaction solution produced in the first step to produce a water / alcohol dispersion of titanium phosphate-based compound particles, and a third step of isolating and washing the titanium phosphate-based compound particles.

[0054] In the first step, the water / alcohol mixed solution contains 30-70% by volume of water, and the amount of titanium tetrachloride added is in the range of 0.01-30 parts by volume per 100 parts of the water / alcohol mixed solution. The reaction temperature and the relative humidity of the environment when titanium tetrachloride is mixed with water / alcohol and reacted are 0-35°C and 10-80%, respectively. In this step, hydrolysis and dehydration condensation reactions of titanium tetrachloride proceed, and nanoscale particulate aggregates are generated. If the reaction temperature is too high, the aggregates become large, and in order to make the average particle size of the final product 5-100 nm, a reaction temperature of 0-20°C is more preferable (Non-Patent Documents 12 and 13).

[0055] In the second step, the reaction solution produced in the first step is diluted 10 to 500 times with a solvent such as a water / alcohol mixed solution, and then phosphoric acid is added to cause a reaction. Here, the amount of phosphoric acid added is in the range of 8 to 500 parts per 100 parts of the reaction solution in terms of volume ratio. When phosphoric acid is added to this reaction solution at a temperature of 0 to 35°C, a reaction occurs immediately, titanium phosphate compound particles are generated, and a water / alcohol dispersion solution of titanium phosphate compound particles can be obtained. Here, a dehydration condensation reaction of phosphoric acid occurs, and titanium tetrachloride is hydrolyzed and fused with the dehydration condensate (Non-Patent Document 14), but the effect on the particle size is not large.

[0056] In the third step, the aqueous / alcoholic solution of the titanium phosphate compound produced in the second step is isolated by a method such as centrifugation, drying at normal pressure, or drying under reduced pressure, and taken out as a solid. The aqueous / alcoholic dispersion of the titanium phosphate compound produced in the second step is transparent, and in appearance, the titanium phosphate compound appears to be dissolved, but the titanium phosphate compound fused to the hydrolysis and dehydration condensation product of titanium tetrachloride by the dehydration condensation reaction of phosphoric acid maintains the nanoparticles formed by the hydrolysis and dehydration condensation of titanium tetrachloride, and when the solvent is removed, titanium phosphate compound particles are obtained. The obtained titanium phosphate compound particles are then washed with pure water and / or a solvent to remove by-products, etc., and become a product preferable as an infection prevention and deodorizing cleaning agent.

[0057] Secondly, titanium silicate compound particles are produced using silicon tetrachloride and titanium tetrachloride as main raw materials through a first step of mixing silicon tetrachloride with a mixed solution of water and an aliphatic alcohol having 1 to 4 carbon atoms to cause a reaction, a second step of adding titanium tetrachloride to the reaction solution produced in the first step to produce a water / alcohol dispersion solution of titanium silicate compound particles, and a third step of isolating and washing the titanium silicate compound particles.

[0058] In the first step, the water / alcohol mixed solution contains 30-70% by volume of water, and the amount of silicon tetrachloride added is in the range of 0.01-30 parts by volume relative to 100 parts of the water / alcohol mixed solution. The reaction temperature and the relative humidity of the environment when silicon tetrachloride is mixed with water / alcohol and reacted are 0-35°C and 10-80%, respectively. In this step, hydrolysis and dehydration condensation reactions of silicon tetrachloride proceed, and nanoscale particle aggregates are generated. However, as with titanium tetrachloride, if the reaction temperature is too high, the particle size becomes large, and in order to make the average particle size of the final product 5-100 nm, a reaction temperature of 0-20°C is more preferable.

[0059] In the second step, 8 to 100 parts by volume of titanium tetrachloride is added to 100 parts by volume of the reaction solution produced in the first step, and the reaction is carried out at a reaction temperature of 0 to 35°C and a relative humidity of the environment of 10 to 80%, respectively, to obtain a water / alcohol dispersion solution of titanium silicate compound particles. In this step, the hydrolysis and dehydration condensation reaction of titanium tetrachloride proceeds, and the titanium silicate compound is generated by fusing with the hydrolysis and dehydration condensation reaction product of silicon tetrachloride. However, if the reaction temperature is too high, the aggregates become large, so that a reaction temperature of 0 to 20°C is more preferable in order to make the average particle size of the final product 5 to 100 nm (Non-Patent Documents 12 and 13).

[0060] In the third step, the aqueous / alcohol dispersion of the titanium silicate compound particles produced in the second step is isolated by a method such as centrifugation, drying at normal pressure, or drying under reduced pressure, and taken out as a solid. The produced titanium silicate compound is TiO 2 SiO 2 The titanium silicate compound particles produced in the second step are dispersed in water / alcohol and are transparent. In appearance, the titanium silicate compound appears to be dissolved, but it is actually a hydrolysis and dehydration condensation product of silicon tetrachloride. Titanium tetrachloride The titanium silicate compound fused by hydrolysis and dehydration condensation reaction forms nanoparticles, and when the solvent is removed, titanium silicate compound particles are obtained. The obtained titanium silicate compound particles are washed with pure water and / or a solvent to remove by-products, etc., and become a product preferable as an infection prevention and deodorizing cleaning agent.

[0061] Thirdly, the titanium borate compound is produced using boric acid and titanium tetrachloride as the main raw materials through a first step of mixing boric acid with a mixed solution of water and an aliphatic alcohol having 1 to 4 carbon atoms to cause a reaction, a second step of adding titanium tetrachloride to the reaction solution produced in the first step to produce a water / alcohol dispersion of titanium borate compound particles, and a third step of isolating and washing the titanium borate compound particles.

[0062] In the first step, the water / alcohol mixed solution contains 30-70% by volume of water, and the amount of boric acid added is in the range of 0.01-30 parts by volume relative to 100 parts of the water / alcohol mixed solution. The reaction temperature and the relative humidity of the environment when boric acid and water / alcohol are mixed and reacted are 20-50°C and 10-80%, respectively. The alkyl borate generated from boric acid and alcohol undergoes hydrolysis and dehydration condensation reactions, and nanoscale particle aggregates of the hydrolysis and dehydration condensation product are generated (Non-Patent Document 15).

[0063] In the second step, 8 to 100 parts by volume of titanium tetrachloride is added to 100 parts by volume of the reaction solution produced in the first step, and the reaction is carried out at a reaction temperature of 0 to 35°C and a relative humidity of the environment of 10 to 80%, respectively, to produce titanium borate compound particles, and a water / alcohol dispersion solution of titanium borate compound particles can be obtained. In this step, the hydrolysis and dehydration condensation reaction of titanium tetrachloride proceeds, and the titanium tetrachloride is fused with the hydrolysis and dehydration condensation reaction product of the alkyl borate, Titanium borate However, if the reaction temperature is too high, the particle size will be large. Therefore, in order to make the average particle size of the final product 5 to 100 nm, a reaction temperature of 0 to 20°C is more preferable (Non-Patent Documents 12 and 13).

[0064] In the third step, the aqueous / alcohol dispersion of the titanium borate compound particles produced in the second step is isolated by a method such as centrifugation, drying at normal pressure, or drying under reduced pressure, and taken out as a solid. The produced titanium borate compound is TiO 2 ·B 2 O 3 The water / alcohol dispersion of titanium borate compound particles produced in the second step is transparent, and from the outside it looks like titanium borate compound is dissolved, but it is actually a compound that has been hydrolyzed and dehydrated and condensed with alkyl borate. Titanium tetrachlorideThe titanium borate compound fused by hydrolysis and dehydration condensation reaction forms nanoparticles, and when the solvent is removed, titanium borate compound particles are obtained. The obtained titanium borate compound particles are washed with pure water and / or a solvent to remove by-products, etc., and become a product preferable as an infection prevention and deodorizing cleaning agent.

[0065] The mixture of titanium phosphate compound particles, titanium silicate compound particles, and titanium borate compound particles thus produced is dispersed in pure water, a mixed solvent of pure water and alcohol, a mixed solvent of electrolytic water and alcohol, and a pure water, a mixed solvent of pure water and alcohol, and a mixed solvent of electrolytic water and alcohol in which polysaccharides, an alkali metal salt of polysaccharides, a polymer having a quaternary ammonium salt, and a surfactant having a quaternary ammonium salt are dissolved to produce an infection prevention and deodorant cleaner. The method of producing the infection prevention and deodorant cleaner is not particularly limited, and a general air disperser and a liquid disperser can be used, but a liquid disperser is preferred. For example, a high-speed rotating shear type agitator such as a disperser, a medium agitation mill such as a ball mill, a sand mill, and an attritor, a colloid mill represented by a homogenizer and a roll mill, and an ultrasonic disperser are selected and used according to the viscosity of the medium.

[0066] In addition, the infection prevention and deodorizing cleaner, which is prepared by dispersing a mixture of titanium phosphate compound particles, titanium silicate compound particles, and titanium borate compound particles in pure water, a mixed solvent of pure water and alcohol, and a mixed solvent of electrolytic water and alcohol, as well as in pure water, a mixed solvent of pure water and alcohol, and a mixed solvent of electrolytic water and alcohol in which polysaccharides, alkali metal salts of polysaccharides, polymers having quaternary ammonium salts, and surfactants having quaternary ammonium salts are dissolved, contains a component that prevents the proliferation of microorganisms, and it is preferable to add water-soluble preservatives such as sodium benzoate, calcium sorbate, p-oxybenzoic acid alkyl esters, sodium propionate, and calcium propionate, and water-soluble antioxidants such as L-ascorbic acid, isoascorbic acid, and citric acid.

[0067] The infection-preventing and deodorizing cleaner of the present invention has been described above. There are a wide variety of combinations of cleaners, and the cleaner can be used in a variety of forms depending on the method and purpose of use.

[0068] For example, the above-mentioned dispersion, which is an infection prevention and deodorant cleaning agent, can be stored and used. In this case, the above-mentioned dispersion can be impregnated into woven fabric, nonwoven fabric, gauze, cotton, sponge, and superabsorbent polymer, or a composite of two or more selected from woven fabric, nonwoven fabric, gauze, cotton, sponge, and superabsorbent polymer, and can be used by pasting it onto masks, diapers, socks, bandages, napkins, panty liners, etc., or can be used as wet tissues and wipes, etc., for washing hands and feet, and as cleaning sheets for toilets and kitchen utensils, etc. In addition, the above-mentioned dispersion can be absorbed into masks, diapers, socks, bandages, napkins, panty liners, etc., and can be fully absorbed into a tampon and used as a vaginal cleanser.

[0069] In particular, for use in preventing infections caused by various fungi, bacteria, and viruses, an effective infection prevention and deodorizing cleaner is one in which a mixture of titanium phosphate compound particles, titanium silicate compound particles, and titanium borate compound particles is dispersed in electrolytic water or a mixed solvent of electrolytic water and alcohol in which a polymer having a quaternary ammonium salt has been dissolved.

[0070] Furthermore, when used as sanitary napkins, panty liners, tampons, and other sanitary products, an even more effective infection-preventing and deodorizing cleanser is one in which a mixture of titanium phosphate-based compound particles, titanium silicate-based compound particles, and titanium borate-based compound particles is dispersed in a mixed solvent of electrolytic water or a mixed solvent of electrolytic water and alcohol in which an appropriate amount of lactic acid has been mixed, in which a polymer having a quaternary ammonium salt has been dissolved.

[0071] The method of using the infection prevention and deodorizing cleaner of the present invention is very convenient for home use. By simply storing the infection prevention and deodorizing cleaner in a spray bottle, it is possible to directly spray it on hands and feet, or to spray it on living items including curtains, rugs, bedding, etc., and on clothes and personal items such as underwear, socks, hats, T-shirts, and sports uniforms, to impart infection prevention and deodorizing functions against fungi, bacteria, and viruses.

[0072] However, instead of storing it as an infection prevention and deodorant cleaning agent, it is also possible to store and use it as a mixture of titanium phosphate compound particles, titanium silicate compound particles, and titanium borate compound particles.In this case, the mixture of titanium phosphate compound particles, titanium silicate compound particles, and titanium borate compound particles is put into pure water, electrolytic water, a mixed solvent of pure water and alcohol, or a mixed solvent of electrolytic water and alcohol, and dispersed with a simple stirrer, and then immediately impregnated into woven fabric, nonwoven fabric, gauze, cotton, sponge, and superabsorbent resin, and two or more composites selected from woven fabric, nonwoven fabric, gauze, cotton, sponge, and superabsorbent resin, and can be used by pasting it with masks, diapers, socks, bandages, napkins, and panty liners, or can be used as it is as wet tissues and wipes, etc., for washing hands and feet, and for cleaning sheets for toilets and kitchen utensils, etc. It can also be absorbed into masks, diapers, socks, bandages, napkins, panty liners, etc., and can also be used as a vaginal cleanser by fully absorbing it into a tampon.

[0073] In addition, the infection-preventing and deodorizing cleaner of the present invention can be impregnated into woven fabric, nonwoven fabric, gauze, cotton, sponge, and superabsorbent polymer, or a composite of two or more selected from woven fabric, nonwoven fabric, gauze, cotton, sponge, and superabsorbent polymer, and then packaged in a packaging material that can block outside air, such as a polyolefin film, a polyethylene vinyl acetate copolymer film, a polyethylene terephthalate film, etc., or a laminate of these films with a metal foil such as aluminum or a metal vapor-deposited film and polyvinyl alcohol, etc., and stored for appropriate use or for supply as a product.

[0074] In particular, for wet tissues, towels, diapers, napkins, panty liners, tampons, etc., it is preferable from the standpoint of safety and hygiene to package woven fabric, nonwoven fabric, gauze, cotton, sponge, superabsorbent polymer, etc., impregnated with the infection-preventing and deodorizing cleaner of the present invention, or a composite of two or more selected from woven fabric, nonwoven fabric, gauze, cotton, sponge, superabsorbent polymer, etc.

[0075] On the other hand, since the woven fabric, nonwoven fabric, gauze, cotton, sponge, and superabsorbent resin impregnated with the infection prevention and deodorizing cleaner of the present invention are disposable consumables, in order to realize environmental conservation and a sustainable recycling-based society in recent years, it is preferable to use biodegradable materials. Gauze and cotton are often made of biodegradable natural cellulose fibers, but the woven fabric, nonwoven fabric, sponge, and superabsorbent resin used in masks, diapers, sanitary products, etc. are often made from synthetic polymers as raw materials.

[0076] Therefore, the sanitary products impregnated with the infection-preventing and deodorizing cleaning agent of the present invention are characterized in that the woven fabric, nonwoven fabric, gauze, cotton, sponge, and superabsorbent resin that constitute them are made from biodegradable polymers such as those listed below.

[0077] Preferred biodegradable polymers include poly(L-lactide) (PLA), poly(3-hydroxybutyrate) (PHB), poly(3-hydroxybutyrate-co-3-hydroxyhexanoate) (PHBH), polybutylene succinate (PBS), polybutylene succinate adipate (PBSA), polybutylene adipate terephthalate (PBAT), polyethylene terephthalate succinate (PETS), polyglycolide (PGA), and poly(ε-caprolactone) (PCL), as well as cellulose derivatives such as acetyl cellulose and starch derivatives.

[0078] Woven fabrics, nonwoven fabrics, gauze, and cotton are manufactured using processed fibers of these polymers, and sponges are manufactured by processing these polymers together with a foam such as carbon dioxide.

[0079] However, since the superabsorbent resin does not absorb moisture sufficiently when the above-mentioned biodegradable polymer is simply used, the sanitary product of the present invention is characterized by using the following biodegradable superabsorbent resin.

[0080] First, superabsorbent resins are aggregates of gelled fine particles such as PLA, PHB, PHBH, PBS, PBSA, PBAT, PETS, PGA, and PCL, as well as cellulose derivatives and starch derivatives, with water-soluble polymers such as polyvinyl alcohol, polyacrylates, polymethacrylates, polyacrylamides, and polyalkylene glycols, as well as alkali metal salts of cellulose derivatives and polysaccharides. These have excellent water absorption properties because they are porous and only require about 1 to 10% by weight of water-soluble polymers. In particular, when gelling fine particles of biodegradable polymers, a superabsorbent resin having biodegradability produced by crosslinking with cellulose derivatives using 1,2,3,4-butanetetracarboxylic dianhydride and then forming an alkali metal salt is most preferred because the water-soluble polymer itself is water-absorbent but does not dissolve and is biodegradable (Non-Patent Documents 16 and 17).

[0081] The second type is a superabsorbent resin that is a crosslinked copolymer particle of PLA, PHB, PHBH, PBS, PBSA, PBAT, PETS, PGA, and PCL monomers with alkylene glycol and glycerin (Non-Patent Document 18).

[0082] Thirdly, biodegradable superabsorbent resins are produced by dispersing particles of PLA, PHB, PHBH, PBS, PBSA, PBAT, PETS, PGA and PCL in the aqueous solution polymerization or reversed suspension polymerization method for producing conventional polyacrylate, polyacrylate, polysulfonate, maleic anhydride, polyacrylamide, polyvinyl alcohol and polyethylene oxide superabsorbent crosslinked particles.

[0083] The amount of water absorbed by the biodegradable superabsorbent polymers described above can be controlled by the composition and production method, so it is preferable to use a superabsorbent polymer appropriate for the application. Effect of the Invention

[0084] The infection-preventive and deodorizing cleaner of the present invention has antifungal activity, antibacterial activity, antiviral activity, and deodorizing activity, and exhibits excellent infection-preventive and deodorizing effects as an infection-preventive and deodorizing cleaner for cleaning kitchen utensils, toilet utensils, etc., intended to prevent food poisoning and contamination, etc., caused by fungi, bacteria, and viruses; an infection-preventive and deodorizing cleaner for protecting the hands, face, nose, mouth, throat, etc., intended to prevent pneumonia, influenza, etc., caused by bacteria and viruses; an infection-preventive and deodorizing cleaner for keeping the hands, feet, and genitals clean, intended to prevent tinea and candidiasis, etc., caused by fungi and bacteria; and an infection-preventive and deodorizing cleaner for keeping the vagina and external genitalia of the internal genital organs of healthy adult female reproductive organs clean, intended to prevent vaginal infections caused by bacteria and fungi. Therefore, it is suitable for "self-medication" or "personal care" in daily life, where one keeps one's body clean and healthy, and can be widely used as hygiene products in the fields of sanitary products, baby products, nursing care products, sanitary products, etc. Moreover, it can be sprayed directly on hands and feet to prevent infection, and can also be sprayed on daily necessities including curtains, rugs, bedding, etc., as well as clothing and personal items such as underwear, socks, hats, T-shirts, and sports uniforms, to impart infection prevention functions against fungi, bacteria, and viruses and deodorization functions.

[0085] In particular, the sanitary products of the present invention are composed of woven fabrics, nonwoven fabrics, gauze, cotton, sponges, and superabsorbent resins, etc., impregnated with the infection-preventing and deodorizing cleaning agent of the present invention, and because these materials are manufactured using biodegradable polymers as raw materials, they provide sanitary products that meet the demands of modern society for environmental conservation and the realization of a sustainable, recycling-oriented society. [Brief description of the drawings]

[0086] [Figure 1]This is a schematic diagram showing the appearance of a hygiene product according to one embodiment of the present invention, in which a biodegradable superabsorbent resin impregnated with an infection prevention and deodorizing cleaning agent and contained in a biodegradable nonwoven bag is attached to the pocket of a biodegradable mask to prevent infections such as pneumonia and influenza caused by bacteria and viruses. [Diagram 2] FIG. 1 is a schematic diagram of a cross section of a baby diaper, illustrating a method of impregnating the cotton-like pulp of a typical baby diaper with an infection prevention and deodorizing cleaning agent and using the same, according to one embodiment of the present invention. [Diagram 3] FIG. 1 is a schematic cross-sectional view of a sanitary napkin used as a vaginal cleansing product, in which a typical applicator-type tampon is impregnated with an infection prevention and deodorant cleanser according to one embodiment of the present invention. DETAILED DESCRIPTION OF THE PREFERRED EMBODIMENTS

[0087] In order to more clearly and specifically explain the infection prevention and deodorizing cleaner of the present invention, and the daily necessities, clothing, and personal items using the same, an example of the infection prevention and deodorizing cleaner will be described below, and examples in which the cleaner is applied to sanitary products such as masks, diapers, and tampons will be described as representative examples. However, the present invention is not limited to the following example, and various modifications can be made within the scope of the present invention, and the present invention is limited only by the technical ideas described in the claims. <Preparation of titanium phosphate compound particles>

[0088] The titanium phosphate compound was produced through a first step of mixing titanium tetrachloride with a mixed solution of water and propyl alcohol to cause a reaction, a second step of adding phosphoric acid to the reaction solution produced in the first step to produce a water / alcohol dispersion solution of titanium phosphate compound particles, and a third step of isolating the titanium phosphate compound particles.

[0089] In the first step, the water / alcohol mixed solution had 50% water by volume, the amount of titanium tetrachloride added was in the range of 10 parts by volume relative to 100 parts of the water / alcohol mixed solution, and the reaction temperature and the relative humidity of the environment when titanium tetrachloride and water / alcohol were mixed and reacted were 0°C and 50%, respectively. In the second step, the reaction solution produced in the first step was diluted 250 times with a solvent such as a water / alcohol mixed solution, and then 250 parts by volume of phosphoric acid was added to 100 parts of this reaction solution and reacted to produce titanium phosphate compound particles. Then, in the third step, the titanium phosphate compound particles were separated by centrifugation of the water / alcohol dispersion solution of the titanium phosphate compound particles produced in the second step, and the titanium phosphate compound particles were isolated by drying under reduced pressure. Furthermore, the titanium phosphate compound particles were produced by washing three times with a water / propyl alcohol mixed solvent and then drying under reduced pressure. The average particle size of this titanium phosphate compound was about 50 nm by electron microscope observation. <Adjustment of infection prevention and deodorizing cleaning agent>

[0090] A water / alcohol mixed solvent was prepared by dissolving 15 g of 1-butanol in 485 g of distilled water, and then 4 g of cationic polyvinyl alcohol, Gohsenex (registered trademark) K-434 (manufactured by Mitsubishi Chemical Corporation), was dissolved in 96 g of the mixed solvent to prepare a dispersion medium for titanium phosphate compound particles.

[0091] 5 mg of the titanium phosphate compound particles prepared was added to 95 g of this dispersion medium and dispersed with a homogenizer to obtain the infection prevention and deodorizing cleaning agent of the present invention. The dispersion stability of the titanium phosphate compound particles was good, and they did not settle for more than one month.

[0092] The above-mentioned infection prevention and deodorizing cleaner is an example, and when a stronger deodorizing effect is required, the titanium phosphate compound particles can be mixed with titanium silicate compound particles and / or titanium borate compound particles in a predetermined weight ratio in the range of 100:50 to 100:10. When both titanium silicate compound particles and titanium borate compound particles are mixed, the blending ratio is preferably 100:10 to 100:50 by weight.

[0093] In addition, from the viewpoint of antibacterial activity and antiviral activity, it is preferable to use electrolyzed water, particularly slightly acidic electrolyzed water, instead of distilled water. As for the alcohol, methanol, ethanol, 1-propanol, and 1-pentanol can be selected, but it is more preferable to add a small amount of 1-pentanol.

[0094] Furthermore, in order to improve the dispersion stability, antibacterial activity and antiviral activity of the titanium phosphate compound particles, titanium silicate compound particles and titanium borate compound particles, polysaccharide derivatives and surfactants having quaternary ammonium salts can be used instead of polyvinyl alcohol having quaternary ammonium salts, but it is particularly preferable to use guar hydroxypropyltrimonium chloride and hydroxypropyltrimonium hyaluronate, which are polysaccharide derivatives having quaternary ammonium salts.

[0095] Although not included in the above examples, when used as a vaginal cleansing product, it is more preferable to add lactic acid at about 0.1 to 9.0% by weight of the infection prevention and deodorant cleanser in order to adjust the pH to 3.5 to 4.5, which is equivalent to the vaginal environment.

[0096] A water-soluble preservative and / or a water-soluble antioxidant may be added in an amount of 0.01% by weight to 1.0% by weight of the infection prevention and deodorant cleaning agent. <Production of sanitary products>

[0097] 1 shows a schematic diagram of the appearance of a sanitary product according to one embodiment of the present invention, in which a biodegradable superabsorbent resin 13 impregnated with an infection prevention and deodorizing cleaning agent and contained in a biodegradable nonwoven bag is attached to a pocket 12 of a biodegradable mask 1 to prevent infections such as pneumonia and influenza caused by bacteria and viruses. It should be noted that the mask 1 and the superabsorbent resin 13 are not necessarily limited to those that are biodegradable, and may be a mask and a superabsorbent resin made of non-biodegradable fibers.

[0098] The infection prevention and deodorizing cleaner thus prepared is impregnated into a biodegradable superabsorbent resin 13 contained in a biodegradable nonwoven bag, and the bag is then placed in a pocket 12 on a mask 1, thereby preventing bacteria and viruses from entering the nose and mouth and causing infections such as pneumonia and influenza.

[0099] 2 shows a method according to one embodiment of the present invention in which a surface material 23 such as a nonwoven fabric that comes into contact with the bottom of a typical disposable diaper for babies 2 is impregnated with an infection prevention and deodorizing detergent, thereby protecting the soft bottom of an infant or small child wearing the disposable diaper for babies 2 from microorganisms that may grow on the bottom. Not only the surface material 23 but also the absorbent paper 211, the cotton-like pulp 212, and the highly absorbent resin 213 may be impregnated with the infection prevention and deodorizing detergent to the extent that it does not inhibit the absorption of urine.

[0100] FIG. 3 is a schematic cross-sectional view of a sanitary napkin according to one embodiment of the present invention, in which a tampon 31 of a general applicator-type tampon 3 is impregnated with an infection prevention and deodorant cleanser and used as a vaginal cleansing product.

[0101] In this way, by regularly washing the inside of the vagina with a vaginal cleansing product in which the infection prevention and deodorant cleanser is impregnated into a tampon 3, it is possible to prevent vaginal infections caused by the invasion of various fungi and bacteria, and also to maintain the balance of the vaginal bacterial flora and prevent vaginal infections. In this case, it is particularly preferable to use the infection prevention and deodorant cleanser containing lactic acid in an amount of about 0.1 to 9.0% by weight. <Evaluation>

[0102] Evidence has already been obtained for the antifungal, antibacterial, and antiviral activities of titanium phosphate compounds alone. As in the above examples, various evaluations of masks, diapers, and tampons as preventive hygiene products using infection prevention and deodorants are ongoing, and because of the impracticality of patent applications, which require time, priority was given to filing the applications. However, the effectiveness of the deodorant activity has already been confirmed by subject sensory evaluation. [Industrial Applicability]

[0103] The infection-preventing and deodorant vaginal cleanser of the present invention and the sanitary goods using the same have antifungal activity, antibacterial activity, antiviral activity, and deodorant activity, and can be applied to infection-preventing and deodorant cleansers for the purpose of "self-medication" or "personal care", as well as to daily necessities, clothing, and personal items using the same. More specifically, the infection-preventing and deodorant cleansers can be used to prevent the invasion of infectious disease-causing pathogens such as fungi, bacteria, and viruses into the human body, and to sanitary goods using the same, in order to keep the body clean and healthy in daily life without having to go to a medical institution. In particular, the present invention can be used in a wide range of fields, such as an infection-preventing and deodorizing cleaner for cleaning kitchen utensils and toilet utensils, and sanitary products such as towels and rags using the same, an infection-preventing and deodorizing cleaner for protecting the hands, face, nose, mouth, throat, and the like ... infection-preventing and deodorizing cleaner for keeping the hands, feet, and genitals clean, and the like, and the like, and the like, and the like, and the like, and the like, and the like, and the like, and the infection-preventing and deodorizing cleaner for keeping the vagina and external genitalia of the internal genitalia of healthy adult females clean, and the infection-preventing and deodorizing cleaner for keeping the vagina and external genitalia of the internal genitalia of healthy adult females clean, and the like, and the like, and the sanitary products such as napkins and tampons using the same, and the like.

[0104] However, the present invention is not limited thereto, and can be used for daily necessities such as curtains, rugs, and bedding, underwear, socks, hats, T-shirts, and sports uniforms, as well as clothing and personal items such as shoes, bags, and accessories, as well as hobby and recreational items such as pet mats, toilets, and clothing, and athletic equipment such as gloves and masks for various sports, etc. Furthermore, it is considered that the present invention can be applied as an antibacterial agent and antiviral agent in cosmetics, buildings, electronic devices, pools, sewage treatment plants, etc., and the industrial applicability of the present invention is extremely great. [Explanation of symbols]

[0105] 1. Biodegradable masks 11 Ear hook 12 Pockets 13. Biodegradable nonwoven bags containing biodegradable superabsorbent polymers 2. Baby diapers 21 Water absorbing material 211 Water-absorbing paper 212 Cotton-like pulp 213 Super absorbent resin 22 Waterproof material 23 Surface material 24 Leak-proof 3D gathers 25 Tape A Butt 3. Tampon applicator 31 Tampons 32 Removal cord 33 Insertion tube 34 Extrusion inner cylinder 35 Gripping part

Claims

1. A dispersion medium containing a polyvinyl alcohol having a quaternary ammonium salt and / or hydroxypropyltrimonium hyaluronate as a dispersant in a solvent of slightly acidic electrolytic water or pure water in an amount of 0.1 to 30% by weight of the solvent, The infection-preventing and deodorizing cleaner is characterized in that 0.001 to 30% by weight of the dispersion medium is dispersed with titanium phosphate compound particles having an average particle size of 5 to 100 nm and made of a titanium phosphate compound represented by Ti(OH)x(PO4)y(HPO4)z(H2PO4)m(OR)n (R is an alkyl group having 1 to 4 carbon atoms, x, y, z, m and n are each a number of 0 or more, and x≧1, y+z+m≧1 and x+3y+2z+m+n=4 are satisfied).

2. The infection prevention and deodorization cleaning agent according to claim 1, characterized in that one or more selected from methanol, ethanol, and 1-propanol are added to the solvent of the slightly acidic electrolyzed water or the pure water in a concentration of 8 to 20% by weight.

3. The infection prevention and deodorization cleaning agent according to claim 1, characterized in that 1-butanol at a concentration of 6% by weight or 1-pentanol at a concentration of 2% by weight is added to the solvent of the slightly acidic electrolyzed water or the pure water.

4. The titanium phosphate compound particles are TiO having an average particle size of 5 to 100 nm. ２ SiO ２ and / or TiO having an average particle size of 5 to 100 nm. ２ ・B ２ O ３ The infection prevention and deodorization cleaning agent according to any one of claims 1 to 3, characterized in that titanium borate-based compound particles made of a titanium borate-based compound represented by the formula (I) are blended in a weight ratio of (the titanium phosphate-based compound particles):(the titanium silicate-based compound particles and / or the titanium borate-based compound particles)=100:50 to 100:

10.

5. The infection-preventing and deodorizing cleaning agent according to claim 4, characterized in that the titanium silicate-based compound and the titanium borate-based compound particles are mixed in a weight ratio of (the titanium silicate-based compound):(the titanium borate-based compound particles)=100:10 to 100:

50.

6. 4. The infection prevention and deodorizing cleaning agent according to claim 1, wherein the infection prevention and deodorizing cleaning agent contains 0.1 to 9.0% by weight of lactic acid.

7. 5. The infection prevention and deodorizing cleaner according to claim 4, characterized in that the infection prevention and deodorizing cleaner contains 0.1 to 9.0% by weight of lactic acid.

8. 6. The infection prevention and deodorizing cleaning agent according to claim 5, characterized in that the infection prevention and deodorizing cleaning agent contains 0.1 to 9.0% by weight of lactic acid.

9. A sanitary product comprising a woven fabric, a nonwoven fabric, gauze, cotton, a sponge, and a superabsorbent polymer, and a composite of two or more selected from the woven fabric, the nonwoven fabric, the gauze, the cotton, the sponge, and the superabsorbent polymer, impregnated with the infection prevention and deodorizing cleaning agent according to any one of claims 1 to 3.

10. A sanitary product in which the infection prevention and deodorizing cleaning agent according to claim 4 is impregnated into a woven fabric, a nonwoven fabric, gauze, cotton, a sponge, and a superabsorbent polymer, as well as a composite of two or more selected from the woven fabric, the nonwoven fabric, the gauze, the cotton, the sponge, and the superabsorbent polymer.

11. A sanitary product in which the infection prevention and deodorizing cleaning agent according to claim 5 is impregnated into a woven fabric, a nonwoven fabric, gauze, cotton, a sponge, and a superabsorbent polymer, as well as a composite of two or more selected from the woven fabric, the nonwoven fabric, the gauze, the cotton, the sponge, and the superabsorbent polymer.

12. A sanitary product in which the infection prevention and deodorizing cleaning agent according to claim 6 is impregnated into a woven fabric, a nonwoven fabric, gauze, cotton, a sponge, and a superabsorbent polymer, as well as a composite of two or more selected from the woven fabric, the nonwoven fabric, the gauze, the cotton, the sponge, and the superabsorbent polymer.

13. A sanitary product in which the infection prevention and deodorizing cleaning agent according to claim 7 is impregnated into a woven fabric, a nonwoven fabric, gauze, cotton, a sponge, and a superabsorbent resin, as well as a composite of two or more selected from the woven fabric, the nonwoven fabric, the gauze, the cotton, the sponge, and the superabsorbent resin.

14. A sanitary product in which the infection prevention and deodorizing cleaning agent according to claim 8 is impregnated into a woven fabric, a nonwoven fabric, gauze, cotton, a sponge, and a superabsorbent polymer, or a composite of two or more selected from the woven fabric, the nonwoven fabric, the gauze, the cotton, the sponge, and the superabsorbent polymer.

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