Compositions and methods for providing health benefits to growing animals

Abstract

The present disclosure provides compositions and methods for providing health benefits to growing animals, comprising administering to the animal a food composition comprising a brain development blend, which generally includes DHA, EPA, taurine, choline, thiamine, riboflavin, pantothenic acid, niacin, pyridoxine, vitamin B12, and folic acid.

Description

[Technical field]

[0001] CROSS-REFERENCE TO RELATED APPLICATIONS

[0001] This application claims priority to U.S. Provisional Patent Application No. 62 / 950,672, filed December 19, 2019, the disclosure of which is incorporated herein by reference in its entirety.

[0002] [Background technology]

[0002] Generally, dog and cat foods contain sufficient nutrients for such animals to maintain their overall health. However, many commercial dog and cat foods have been modified to address various nutritional needs. For example, veterinary diets are designed to address kidney problems, cognitive problems, heart health, overweight animals, allergies, skin conditions, etc. Furthermore, formulas are designed for various breeds, sizes, and life stages. For example, some diets are designed for growing animals, adult animals, senior animals, or even super senior animals. Despite the existence of numerous pet food products, there is still a need to develop innovative formulas using ingredients and nutrients designed to enhance the development of growing animals.

[0003] [Summary of the invention]

[0003] In one embodiment, a method for providing a health benefit to a growing animal may include administering to the animal a food composition comprising a brain development blend. The food composition may be administered in an amount that provides from about 10 mg / day to about 3000 mg / day of docosahexaenoic acid (DHA), from about 10 mg / day to about 3000 mg / day of eicosapentaenoic acid (EPA), from about 50 mg / day to about 2000 mg / day of taurine, from about 50 mg / day to about 2000 mg / day of choline, from about 0.1 mg / day to about 50 mg / day of thiamine, from about 0.1 mg / day to about 50 mg / day of riboflavin, from about 0.1 mg / day to about 100 mg / day of pantothenic acid, from about 0.1 mg / day to about 250 mg / day of niacin, from about 0.1 mg / day to about 50 mg / day of pyridoxine, from about 0.1 μg / day to about 1000 μg of vitamin B12, and from about 0.01 mg / day to about 15 mg / day of folic acid. The health effect may be selected from the group consisting of enhanced brain growth and development, improved trainability, improved episodic learning, improved episodic memory, reduced spherical aberration of the eye, enhanced photopic vision, and combinations thereof.

[0004]

[0004] In another embodiment, a food composition for a growing animal may include a brain development blend. The brain development blend may include about 5% to about 35% DHA, about 5% to about 35% EPA, about 5% to about 35% taurine, about 5% to about 40% choline, about 0.01% to about 5% thiamine, about 0.01% to about 5% riboflavin, about 0.01% to about 5% pantothenic acid, about 0.1% to about 5% niacin, about 0.01% to about 5% pyridoxine, about 0.0001% to about 1% vitamin B12, and about 0.001% to about 1% folic acid. Generally, the food composition contains an effective amount of the brain development blend sufficient to provide a health benefit selected from the group consisting of enhanced brain growth and development, enhanced trainability, enhanced learning, enhanced memory, reduced spherical aberration of the eye, enhanced photopic vision, and combinations thereof.

[0005]

[0005] Other and further objects, features, and advantages of the present invention will be readily apparent to those skilled in the art.

[0006] [Mode for carrying out the invention] definition

[0006] The term "animal" refers to any animal in need of support for optimal brain and cognitive development and good health during the growth and development stages of its life, including humans, birds, bovines, canines, equines, felines, caprines, lionesses, murines, ovines, or porcines. In one aspect, the animal can be a mammal. In another aspect, the animal can be a companion animal.

[0007] The term "companion animal" refers to domestic animals such as cats, dogs, rabbits, guinea pigs, ferrets, hamsters, mice, gerbils, horses, cows, goats, sheep, donkeys, pigs, etc. In one embodiment, the companion animal may be a canine. In another embodiment, the companion animal may be a feline.

[0008]

[0008] The term "therapeutically effective amount" means an amount of a compound disclosed herein that (i) treats or prevents a particular disease, condition, or disorder, (ii) relieves, ameliorates, or eliminates one or more symptoms of a particular disease, condition, or disorder, or (iii) prevents or delays the onset of one or more symptoms of a particular disease, condition, or disorder described herein.

[0009]

[0009] The terms "treating", "treat" and "treatment" include both prophylactic, i.e., preventative, and palliative treatment.

[0010]

[0010] The term "health and / or wellness of an animal" refers to an animal's physical, mental and social well-being and not merely the absence of disease or infirmity.

[0011]

[0011] The term "in conjunction" means that the food composition, its components, or other compositions disclosed herein are administered to an animal (1) together in a single food composition, or (2) separately at about the same time or periodically, using the same or different routes of administration, with the same or different frequencies. "Periodic" means that the food composition, its components, or other compositions are administered on a schedule acceptable for the particular compound or composition. "About the same time" generally means that the food composition, its components, or other compositions are administered at the same time or within about 72 hours of each other.

[0012]

[0012] The term "food" or "food product" or "food composition" means a product or composition intended for consumption by animals, including humans, and which provides nutrition to the animal.

[0013] The term "regularly" refers to administration at least once a month, and in one aspect, administration at least once a week. In certain embodiments, more frequent administration or intake can be performed, such as twice a week or three times a week. In one aspect, the dosing regimen can include intake at least once a day.

[0014]

[0014] The term "single package" means that the components of the kit are in or physically associated with one or more containers and are considered as one unit for manufacture, distribution, sale, or use. Containers include, but are not limited to, packages such as bags, boxes, cartons, bottles, shrink-wrap packages, stapled or otherwise attached components, or combinations thereof. A single package may be containers of a food composition or its ingredients physically associated such that they are considered as one unit for manufacture, distribution, sale, or use.

[0015]

[0015] The term "virtual package" means that the components of a kit are associated with one or more physical or virtual kit components instructions that instruct the user how to obtain the other components (e.g., a bag or other container containing one component and instructions instructing the user to visit a website, contact a recorded message or fax return service, view a visual message, or contact a caregiver or instructor to obtain safety or technical information regarding one or more components of the kit).

[0016]

[0016] The term "about" means ±20% of the numerical value, in one embodiment ±10%, in another embodiment ±5%, and in a more specific embodiment ±2%. For example, in one embodiment where about is ±20% of the numerical value, the phrase "about 10% to about 20%" can include ranges of 8% to 24% or 12% to 16%, including any subranges thereof.

[0017]

[0017] As used in this specification, embodiments, aspects, and examples using the word "comprising" or other non-limiting language may be replaced with embodiments of "consisting essentially of" and "consisting of."

[0018]

[0018] The term "complete and balanced" when referring to a food composition means a food composition that contains all known necessary nutrients in appropriate amounts and proportions based on the recommendations of recognized authorities in the field of animal nutrition, and thus can serve as the sole source of dietary intake to sustain life or promote production without the need for additional nutritional sources. Nutritionally balanced pet food and animal food compositions, such as complete and balanced food compositions formulated according to standards established by the Association of American Feed Control Officials (AAFCO) as of January 1, 2019, are widely known and widely used in the art.

[0019]

[0019] All percentages expressed herein are by weight of the composition on a dry matter basis unless otherwise stated. Those skilled in the art will understand that the term "dry matter basis" means that the concentration or percentage of an ingredient in a composition is measured or specified after all free moisture in the composition has been removed. When referring to a food composition, such percentages are relative to the food composition. When referring to a blend, such percentages are relative to the blend.

[0020]

[0020] As used herein, ranges are used herein as a shorthand to avoid having to list and describe each and every value within that range. Any appropriate value within such a range can be selected as the upper, lower, or boundary value of the range, as appropriate.

[0021]

[0021] As used herein, the singular form of a word includes the plural, and vice versa, unless the context clearly dictates otherwise. Thus, references to "a," "an," and "the" generally include the plural of the respective term. For example, a reference to the singular "a supplement," "a method," or "a food" includes the plural "supplements," "methods," or "foods." Similarly, the words "comprise," "comprises," and "comprising" should be construed as inclusive rather than exclusive. Similarly, the terms "include," "including," and "or" should all be construed as inclusive unless such a construction is clearly prohibited by the context. Similarly, the term "examples," particularly when followed by a listing of terms, is merely illustrative and illustrative and should not be considered exclusive or inclusive.

[0022]

[0022] The methods and compositions disclosed herein, as well as other developments, are not limited to the particular methodology, procedures, and reagents described herein, because they may vary, as will be understood by those skilled in the art. Moreover, the terminology used herein is for the purpose of describing particular embodiments only, and is not intended to, and does not, limit the scope of the disclosure or claims.

[0023]

[0023] Unless otherwise specified, all technical and scientific terms, terminology, and acronyms used herein have the meaning commonly understood by a person of ordinary skill in the field(s) of the invention or the field(s) in which the term is used. Although any compositions, methods, products, or other means or materials similar or equivalent to those described herein can be used in the practice of the invention, specific compositions, methods, products, or other means or materials are described herein.

[0024]

[0024] All patents, patent applications, publications, technical and / or journal articles, and other references cited or referenced herein are hereby incorporated by reference in their entirety to the extent permitted by law. The discussion of these references is intended only to summarize the assertions made in the references. No admission is made that any such patents, patent applications, publications, or references, or any portion thereof, are related, essential, or prior art. The right to challenge the accuracy and pertinence of any assertion that such patents, patent applications, publications, and other references are related, essential, or prior art is expressly reserved.

[0025] [Mode for carrying out the invention]

[0025] The methods and compositions of the present invention are based on the discovery that a specific nutrient blend for growing animals has been found to improve trainability, improve episodic learning, improve episodic memory, reduce spherical aberration of the eye, and enhance photopic vision in the animals.

[0026]

[0026] In one embodiment, a method for providing a health benefit to a growing animal may include administering to the animal a food composition comprising a brain development blend. The food composition may be administered in an amount that provides from about 10 mg / day to about 3000 mg / day of DHA, from about 10 mg / day to about 3000 mg / day of EPA, from about 50 mg / day to about 2000 mg / day of taurine, from about 50 mg / day to about 2000 mg / day of choline, from about 0.1 mg / day to about 50 mg / day of thiamine, from about 0.1 mg / day to about 50 mg / day of riboflavin, from about 0.1 mg / day to about 100 mg / day of pantothenic acid, from about 0.1 mg / day to about 250 mg / day of niacin, from about 0.1 mg / day to about 50 mg / day of pyridoxine, from about 0.1 μg / day to about 1000 μg / day of vitamin B12, and from about 0.01 mg / day to about 15 mg / day of folic acid. The health effect may be selected from the group consisting of enhanced brain growth and development, improved trainability, improved episodic learning, improved episodic memory, reduced spherical aberration of the eye, enhanced photopic vision, and combinations thereof.

[0027]

[0027] In another embodiment, the food composition for growing animals may include a brain development blend. The brain development blend may include about 5% to about 35% DHA, about 5% to about 35% EPA, about 5% to about 35% taurine, about 5% to about 40% choline, about 0.01% to about 5% thiamine, about 0.01% to about 5% riboflavin, about 0.01% to about 5% pantothenic acid, about 0.1% to about 5% niacin, about 0.01% to about 5% pyridoxine, about 0.0001% to about 1% vitamin B12, and about 0.001% to about 1% folic acid. Generally, the food composition contains an effective amount of the brain development blend sufficient to provide a health effect selected from the group consisting of enhanced brain growth and development, improved trainability, improved episodic learning, improved episodic memory, reduced spherical aberration of the eye, enhanced photopic vision, and combinations thereof.

[0028] As discussed herein, the brain development blend may be used in a variety of forms, such as pet food compositions, main meal compositions, treats, dietary supplements, etc. In one embodiment, the food composition may include about 15% to about 70% protein, about 5% to about 50% carbohydrate, about 5% to about 40% fat, and the brain development blend.

[0029]

[0029] Generally, the blend generally includes docosahexaenoic acid (DHA), eicosapentaenoic acid (EPA), taurine, choline, thiamine, riboflavin, pantothenic acid, niacin, pyridoxine, vitamin B12, and folic acid. The blend may further include vitamin C and vitamin E. Generally, the blend is provided in an effective amount to provide at least one of the health benefits discussed herein. In one aspect, the health benefit may be improved trainability. In another aspect, the health benefit may be improved episodic learning. In yet another aspect, the health benefit may be improved episodic memory. In yet another aspect, the health benefit may be reduced spherical aberration of the eye. In yet another aspect, the health benefit may be enhanced photopic vision. In yet another aspect, the health benefit may be enhanced brain growth and development.

[0030]

[0030] In general, DHA may be present in the food composition in an amount that provides a daily dose of about 10 mg / day to about 3000 mg / day. In some aspects, DHA may be administered in an amount of about 100 mg / day to about 1000 mg / day, or even about 140 mg / day to about 500 mg / day. In other embodiments, DHA may be present in the food composition in an amount ranging from about 100 mg / kg to about 3000 mg / kg, about 1000 mg / kg to about 3000 mg / kg, or even about 1500 mg / kg to about 2500 mg / kg. Furthermore, DHA may be calculated as the amount of the brain development blend. Thus, DHA may be present in the brain development blend in an amount of about 50 g / kg to about 350 g / kg DHA, about 100 g / kg to about 300 g / kg DHA, or even about 150 g / kg to about 250 g / kg DHA. As a percentage, DHA may be present as part of a brain development blend in an amount of about 5% to about 35%, about 10% to about 30%, or even about 15% to about 25%.

[0031]

[0031] In general, EPA may be present in the food composition in an amount that provides a daily dose of about 10 mg / day to about 3000 mg / day. In some aspects, EPA may be administered in an amount of about 100 mg / day to about 1000 mg / day, or even about 140 mg / day to about 500 mg / day. In other embodiments, EPA may be present in the food composition in an amount ranging from about 100 mg / kg to about 3000 mg / kg, about 1000 mg / kg to about 3000 mg / kg, or even about 1500 mg / kg to about 2500 mg / kg. Furthermore, EPA may be calculated as the amount of the brain development blend. Thus, EPA may be present in the brain development blend in an amount of about 50 g / kg to about 350 g / kg, about 100 g / kg to about 300 g / kg, or even about 150 g / kg to about 250 g / kg. As a percentage, EPA may be present as part of the brain development blend in an amount of about 5% to about 35%, about 10% to about 30%, or even about 15% to about 25%.

[0032]

[0032] Generally, taurine may be present in the food composition in an amount that provides a daily dose of about 50 mg / day to about 2000 mg / day. In some aspects, taurine may be administered in an amount of about 100 mg / day to about 1000 mg / day, or even about 150 mg / day to about 600 mg / day. In other embodiments, taurine may be present in the food composition in an amount ranging from about 100 mg / kg to about 5000 mg / kg, about 1000 mg / kg to about 4000 mg / kg, or even about 1500 mg / kg to about 2500 mg / kg. Furthermore, taurine may be calculated as the amount of the brain development blend. Thus, taurine may be present in the brain development blend in an amount of about 50 g / kg to about 350 g / kg, about 100 g / kg to about 300 g / kg, or even about 150 g / kg to about 250 g / kg. As a percentage, taurine may be present as part of the brain development blend in an amount of about 5% to about 35%, about 10% to about 30%, or even about 15% to about 25%.

[0033]

[0033] Generally, choline may be present in the food composition in an amount that provides a daily dose of about 50 mg / day to about 2000 mg / day. In some aspects, choline may be administered in an amount of about 100 mg / day to about 1000 mg / day, or even about 180 mg / day to about 700 mg / day. In other embodiments, choline may be present in the food composition in an amount ranging from about 100 mg / kg to about 6000 mg / kg, about 1000 mg / kg to about 4000 mg / kg, or even about 2000 mg / kg to about 3000 mg / kg. Furthermore, choline may be calculated as the amount of the brain development blend. Thus, choline may be present in the brain development blend in an amount of about 50 g / kg to about 400 g / kg, about 100 g / kg to about 350 g / kg, or even about 200 g / kg to about 300 g / kg. As a percentage, choline may be present as part of the brain development blend in an amount of about 5% to about 40%, about 10% to about 35%, or even about 20% to about 30%.

[0034]

[0034] In general, thiamine may be present in the food composition in an amount that provides a daily dose of about 0.1 mg / day to about 50 mg / day. In some aspects, thiamine may be administered in an amount of about 0.5 mg / day to about 25 mg / day, or even about 1.5 mg / day to about 12.5 mg / day. In other embodiments, thiamine may be present in the food composition in an amount ranging from about 1 mg / kg to about 150 mg / kg, about 10 mg / kg to about 100 mg / kg, or even about 30 mg / kg to about 80 mg / kg. Additionally, thiamine may be calculated as the amount of the brain development blend. Thus, thiamine may be present in the brain development blend in an amount of about 0.1 g / kg to about 50 g / kg, about 0.5 g / kg to about 20 g / kg, or even about 1 g / kg to about 10 g / kg. As a percentage, thiamine may be present as part of the brain development blend in an amount of about 0.01% to about 5%, about 0.05% to about 2%, or even about 0.1% to about 1%.

[0035]

[0035] In general, riboflavin may be present in the food composition in an amount that provides a daily dose of about 0.1 mg / day to about 50 mg / day. In some aspects, riboflavin may be administered in an amount of about 0.5 mg / day to about 25 mg / day, or even about 1.5 mg / day to about 10 mg / day. In other embodiments, riboflavin may be present in the food composition in an amount ranging from about 1 mg / kg to about 100 mg / kg, about 10 mg / kg to about 50 mg / kg, or even about 10 mg / kg to about 30 mg / kg. Furthermore, riboflavin may be calculated as the amount of the brain development blend. Thus, riboflavin may be present in the brain development blend in an amount of about 0.1 g / kg to about 50 g / kg, about 0.5 g / kg to about 20 g / kg, or even about 1 g / kg to about 10 g / kg. As a percentage, riboflavin may be present as part of the brain development blend in an amount of about 0.01% to about 5%, about 0.05% to about 2%, or even about 0.1% to about 1%.

[0036]

[0036] Generally, pantothenic acid may be present in the food composition in an amount that provides a daily dose of about 0.1 mg / day to about 100 mg / day. In some aspects, pantothenic acid may be administered in an amount of about 0.5 mg / day to about 50 mg / day, or even about 1.5 mg / day to about 25 mg / day. In other embodiments, pantothenic acid may be present in the food composition in an amount ranging from about 1 mg / kg to about 250 mg / kg, about 10 mg / kg to about 100 mg / kg, or even about 25 mg / kg to about 75 mg / kg. Furthermore, pantothenic acid may be calculated as the amount of the brain development blend. Thus, pantothenic acid may be present in the brain development blend in an amount of about 0.1 g / kg to about 50 g / kg, about 0.5 g / kg to about 20 g / kg, or even about 1 g / kg to about 10 g / kg. As a percentage, pantothenic acid may be present as part of the brain development blend in an amount of about 0.01% to about 5%, about 0.05% to about 2%, or even about 0.1% to about 1%.

[0037]

[0037] Generally, niacin may be present in the food composition in an amount that provides a daily dose of about 0.1 mg / day to about 250 mg / day. In some aspects, niacin may be administered in an amount of about 1 mg / day to about 150 mg / day, or even about 10 mg / day to about 50 mg / day. In other embodiments, niacin may be present in the food composition in an amount ranging from about 1 mg / kg to about 600 mg / kg, about 10 mg / kg to about 400 mg / kg, or even about 100 mg / kg to about 300 mg / kg. Additionally, niacin may be calculated as the amount of the brain development blend. Thus, niacin may be present in the brain development blend in an amount of about 1 g / kg to about 50 g / kg, about 10 g / kg to about 30 g / kg, or even about 15 g / kg to about 25 g / kg. As a percentage, niacin may be present as part of a brain development blend in an amount of about 0.1% to about 5%, about 1% to about 3%, or even about 1.5% to about 2.5%.

[0038]

[0038] Generally, pyridoxine may be present in the food composition in an amount that provides a daily dose of about 0.1 mg / day to about 50 mg / day. In some aspects, pyridoxine may be administered in an amount of about 0.5 mg / day to about 20 mg / day, or even about 1 mg / day to about 10 mg / day. In other embodiments, pyridoxine may be present in the food composition in an amount ranging from about 1 mg / kg to about 100 mg / kg, about 10 mg / kg to about 40 mg / kg, or even about 10 mg / kg to about 20 mg / kg. Furthermore, pyridoxine may be calculated as the amount of the brain development blend. Thus, pyridoxine may be present in the brain development blend in an amount of about 0.1 g / kg to about 50 g / kg, about 0.5 g / kg to about 20 g / kg, or even about 1 g / kg to about 10 g / kg. As a percentage, pyridoxine may be present as part of the brain development blend in an amount of about 0.01% to about 5%, about 0.05% to about 2%, or even about 0.1% to about 1%.

[0039]

[0039] Generally, vitamin B12 may be present in the food composition in an amount that provides a daily dose of about 0.1 μg / day to about 1000 μg / day. In some aspects, vitamin B12 may be administered in an amount of about 1 μg / day to about 150 μg / day, or even about 2 μg / day to about 100 μg / day. In other embodiments, vitamin B12 may be present in the food composition in an amount ranging from about 0.01 mg / kg to about 5 mg / kg, from about 0.05 mg / kg to about 2.5 mg / kg, or even from about 0.1 mg / kg to about 1 mg / kg. Furthermore, vitamin B12 may be calculated as the amount of the brain development blend. Thus, vitamin B12 may be present in the brain development blend in an amount of about 0.001 g / kg to about 10 g / kg, from about 0.005 g / kg to about 1 g / kg, or even from about 0.01 g / kg to about 0.1 g / kg. As a percentage, Vitamin B12 may be present as part of a brain development blend in an amount of about 0.0001% to about 1%, about 0.0005% to about 0.1%, or even about 0.001% to about 0.01%.

[0040]

[0040] In general, folic acid may be present in the food composition in an amount that provides a daily dose of about 0.01 mg / day to about 15 mg / day. In some aspects, folic acid may be administered in an amount of about 0.1 mg / day to about 10 mg / day, or even about 0.2 mg / day to about 5 mg / day. In other embodiments, folic acid may be present in the food composition in an amount ranging from about 0.1 mg / kg to about 50 mg / kg, about 0.5 mg / kg to about 20 mg / kg, or even about 1 mg / kg to about 10 mg / kg. Furthermore, folic acid may be calculated as the amount of the brain development blend. Thus, folic acid may be present in the brain development blend in an amount of about 0.01 g / kg to about 10 g / kg, about 0.05 g / kg to about 5 g / kg, or even about 0.1 g / kg to about 1 g / kg. As a percentage, folic acid may be present as part of the brain development blend in an amount of about 0.001% to about 1%, about 0.005% to about 0.5%, or even about 0.01% to about 0.1%.

[0041]

[0041] Generally, vitamin E may be present in the food composition in an amount that provides a daily dose of about 0.1 mg / day to about 500 mg / day. In some aspects, vitamin E may be administered in an amount of about 0.25 mg / day to about 250 mg / day, or even about 0.5 mg / day to about 150 mg / day. In other embodiments, vitamin E may be present in the food composition in an amount ranging from about 1 mg / kg to about 3000 mg / kg, about 10 mg / kg to about 2000 mg / kg, or even about 100 mg / kg to about 1000 mg / kg. Furthermore, vitamin E may be calculated as the amount of the brain development blend. Thus, vitamin E may be present in the brain development blend in an amount of about 1 g / kg to about 250 g / kg, about 5 g / kg to about 150 g / kg, or even about 10 g / kg to about 100 g / kg. As a percentage, Vitamin E may be present as part of the brain development blend in an amount of from about 0.1% to about 25%, from about 0.5% to about 15%, or even from about 1% to about 10%.

[0042]

[0042] Generally, vitamin C may be present in the food composition in an amount that provides a daily dose of about 0.1 mg / day to about 8000 mg / day. In some aspects, vitamin C may be administered in an amount of about 0.5 mg / day to about 4000 mg / day, or even about 1 mg / day to about 2000 mg / day. In other embodiments, vitamin C may be present in the food composition in an amount ranging from about 1 mg / kg to about 5000 mg / kg, about 10 mg / kg to about 3000 mg / kg, or even about 100 mg / kg to about 1000 mg / kg. Furthermore, vitamin C may be calculated as the amount of the brain development blend. Thus, vitamin C may be present in the brain development blend in an amount of about 1 g / kg to about 250 g / kg, about 5 g / kg to about 150 g / kg, or even about 10 g / kg to about 100 g / kg. As a percentage, vitamin C may be present as part of the brain development blend in an amount of about 0.1% to about 25%, about 0.5% to about 15%, or even about 1% to about 10%.

[0043] In some embodiments, the compositions of the present invention may include protein. The protein may be a crude protein material and may include vegetable proteins such as soybean meal, soy protein concentrate, corn gluten meal, wheat gluten, cottonseed, and peanut meal, or animal proteins such as casein, albumin, and meat protein. Examples of meat proteins useful herein include beef, pork, lamb, horse, poultry, fish, and mixtures thereof. In one embodiment, the food composition may include protein in an amount from about 5%, 10%, 15%, 20%, 25%, 30%, 35%, 40%, 45%, 50%, 55%, or even 60% to about 25%, 30%, 35%, 40%, 45%, 50%, 55%, 60%, 65%, or even 70%, including various subranges within these amounts. In one aspect, the protein may be about 30% to about 55% of the food composition.

[0044]

[0044] In some embodiments, the compositions of the present invention may include carbohydrates. Generally, any type of carbohydrate may be used in the food composition. Examples of suitable carbohydrates include grains or cereals such as rice, corn, millet, sorghum, alfalfa, barley, soybeans, canola, oats, wheat, rye, triticale, and mixtures thereof. The compositions may also optionally include other ingredients such as dried whey and other dairy by-products. In one embodiment, the carbohydrates comprise about 5% to about 10% of the food composition. In another embodiment, the carbohydrates comprise about 10% to about 15% of the food composition. In other aspects, the carbohydrates may be present in an amount from about 5%, 10%, 15%, 20%, 25%, 30%, 35%, or even 40% to about 10%, 15%, 20%, 25%, 30%, 35%, 40%, 45%, or even 50%.

[0045] In some embodiments, the food composition may include fat. Examples of suitable fats include animal fats and vegetable fats. In one aspect, the fat source may be an animal fat source, such as tallow or poultry fat. Vegetable oils, such as corn oil, sunflower oil, safflower oil, grape seed oil, soybean oil, olive oil, and other oils rich in monounsaturated and polyunsaturated fatty acids, may also be used. In one embodiment, the food composition may include fat in an amount from about 5%, 10%, 15%, 20%, 25%, 30%, or even 35% to about 10%, 15%, 20%, 25%, 30%, 35%, or even 40%, including various subranges within these amounts. In one aspect, the fat comprises about 25% to about 35% of the food composition.

[0046] Administration can be periodic or intermittent, as needed or desired. In one aspect, the food composition can be administered to the animal periodically. In one aspect, administration can be at least once a week. In certain embodiments, more frequent administration or consumption can be performed, such as two or three times a week. In one aspect, the administration regimen can include consumption at least once a day.

[0047]

[0047] According to the methods described herein, administration can extend from birth through adulthood of the animal, including administration as part of a dietary regimen. In various embodiments, the animal can be a human or a companion animal, such as a dog or cat. In general, the animal can be a juvenile or growing animal. In other embodiments, administration can begin periodically over an extended period of time, for example, continuing for weeks, months, or even years.

[0048]

[0048] Such administration may be carried out for a period of time necessary to achieve one or more of the objectives described herein, such as improving trainability, improving episodic learning, improving episodic memory, reducing spherical aberration of the eye, or enhancing photopic vision in the animal. Other dosage amounts may be appropriate and can be determined based on the initial weight of the animal, as well as other variables such as species, sex, breed, age, and the desired health effect.

[0049] The moisture content of such food compositions varies depending on the nature of the food composition. The food composition may be a dry composition (e.g., kibble), a semi-moist composition, a moist composition, or any mixture thereof. In one embodiment, the composition may be a pet food composition, and in one aspect, a complete and nutritionally balanced pet food. In this embodiment, the pet food may be a "wet food", a "dry food", or a food of "intermediate moisture content". "Wet food" refers to pet food that is typically sold in cans or foil bags and has a moisture content that typically ranges from about 70% to about 90%. "Dry food" refers to pet food (typically in the form of small biscuit-like kibbles) that is similar in composition to wet food, but has a limited moisture content, typically ranging from about 5% to about 15% or 20%. In one embodiment, the composition may have a moisture content of about 5% to about 20%. Dry food products include a variety of foods with different moisture contents that are relatively shelf-stable and resistant to microbial or fungal deterioration or contamination. Also, in one aspect, the dry food composition may be an extruded food product for either humans or companion animals.

[0050]

[0050] The food composition may also contain one or more fiber sources. The term "fiber" includes all sources of "bulk" in foods, whether digestible or resistant, soluble or insoluble, fermentable or non-fermentable. Such fibers may be of vegetable origin, such as marine plants, but fibers of microbial origin may also be used. As known to those skilled in the art, a variety of soluble or insoluble fibers may be used. The fiber source may be beet pulp (from sugar beet), gum arabic, gum talha, psyllium, rice bran, carob gum, citrus pulp, pectin, fructooligosaccharides, short chain oligofructose, mannan oligofructose, soybean fiber, arabinogalactan, galactooligosaccharides, arabinoxylan, or mixtures thereof.

[0051] Alternatively, the fiber source may be a fermentable fiber. Fermentable fibers have previously been reported to be beneficial to the immune system of companion animals. Fermentable fibers or other compositions known to those skilled in the art that provide prebiotics and promote the growth of probiotics in the intestine may also be incorporated into the composition to help promote the effects described herein or to promote the effect on the immune system of the animal.

[0052] In some embodiments, the ash content of the food composition ranges from less than 1% to about 15%. In one aspect, the ash content may be from about 5% to about 10%.

[0053]

[0053] Generally, the food compositions may be suitable for consumption as a meal, a meal component, a snack, a dietary supplement, or a treat by humans and animals, including companion animals such as dogs and cats. Such compositions may include complete foods intended to provide the necessary dietary requirements of the animal. Examples of such food compositions include, but are not limited to, dry foods, wet foods, drinks, bars, pre-prepared frozen foods, pre-prepared preserved foods, pre-prepared refrigerated foods, and the like.

[0054]

[0054] As discussed herein, the food compositions of the present invention may be administered to animals as a complete nutritionally balanced diet, as a dietary supplement alone, or in conjunction with dietary supplements, vitamins, and / or other nutritionally beneficial agents well known to those skilled in the art, as part of an overall health and well-being program for the animal. The compositions of the present invention may also be useful as veterinary therapeutic products. Thus, the compositions may optionally contain carriers, diluents, or excipients, the suitability of which for the intended use will be well known to those skilled in the art.

[0055] The food compositions may further comprise one or more substances such as vitamins, minerals, antioxidants, probiotics, prebiotics, salts, and functional additives such as palatants, colorants, emulsifiers, and antimicrobials or other preservatives. Minerals that may be useful in such compositions include, for example, calcium, phosphorus, potassium, sodium, iron, chloride, boron, copper, zinc, magnesium, manganese, iodine, and selenium. Examples of additional vitamins useful herein include fat-soluble vitamins such as A, D, E, and K. Inulin, amino acids, enzymes, coenzymes, and the like may also be useful for inclusion in various embodiments.

[0056]

[0056] In various embodiments, the food composition comprises at least one of: (1) one or more probiotics; (2) one or more inactivated probiotics; (3) one or more components of the inactivated probiotics, such as proteins, lipids, glycoproteins, etc., that promote similar or identical health effects as the probiotics; (4) one or more prebiotics; and (5) combinations thereof. The probiotics or components thereof can be incorporated into the food composition (e.g., distributed evenly or unevenly in the composition) or applied to the food composition (e.g., applied topically with or without a carrier). Such methods are known to those skilled in the art and are described, for example, in US Pat. No. 5,968,569 and related patents.

[0057]

[0057] Typical probiotics include those from the genus Lactobacilli, Bifidobacteria, or Enterococci, such as Lactobacillus reuteii, Lactobacillus acidophilus, Lactobacillus animalis, Lactobacillus ruminis, Lactobacillus johnsonii, Lactobacillus casei, Lactobacillus paracasei, Lactobacillus rhamnosus, Lactobacillus fermentum, and the like. fermentum, and probiotic strains selected from Bifidobacterium spp., Enterococcus faecium, and Enterococcus spp. In some embodiments, the probiotic strain is Lactobacillus reuteri (NCC2581; CNCM I-2448), Lactobacillus reuteri (NCC2592; CNCM I-2450), Lactobacillus rhamnosus (NCC2583; CNCM I-2449), Lactobacillus reuteri (NCC2603; CNCM I-2451), Lactobacillus reuteri (NCC2613; CNCM I-2452), Lactobacillus acidophilus (NCC2628; CNCM I-2453), Bifidobacterium adolescentis (e.g., NCC2627), Bifidobacterium sp. NCC2657, or Enterococcus faecium SF68 (NCIMB 10415). Generally, the food composition may be selected from the group consisting of about 10 4 ~about 10 12 cfu / individual / day, in one embodiment, 10 5 ~about 1011 cfu / individual / day, and in one particular embodiment, 10 7 ~10 10 The probiotic may be present in an amount sufficient to provide cfu / individual / day. Even if the probiotic is killed or inactivated, the amount of the killed or inactivated probiotic or its components should produce the same beneficial effect as live bacteria of the microorganism. Many such probiotics and their effects are known to those skilled in the art, for example, EP 1213970(B1), EP 1143806(B1), U.S. Patent No. 7189390, EP 1482811(B1), EP 1296565(B1), and U.S. Patent No. 6929793. In one embodiment, the probiotic may be Enterococcus faecium SF68 (NCIMB 10415). In another embodiment, the probiotic may be encapsulated in a carrier using methods and materials known to those skilled in the art.

[0058] As mentioned above, the food composition may contain one or more prebiotics, such as fructooligosaccharides, glucooligosaccharides, galactooligosaccharides, isomaltooligosaccharides, xylooligosaccharides, soybean oligosaccharides, lactosucrose, lactulose, and isomaltulose. In one embodiment, the prebiotic may be chicory root, chicory root extract, inulin, or a combination thereof. Generally, the prebiotics may be administered in an amount sufficient to positively stimulate healthy flora in the gut and allow these "good" bacteria to proliferate. Typical amounts range from about 1 g to about 10 g per feeding, or about 5% to about 40% of the daily recommended amount of dietary fiber for the animal. The probiotics and prebiotics may be part of the composition by any suitable means. Generally, these agents may be mixed with the composition or applied to the surface of the composition, for example by sprinkling or spraying. If the agent is part of a kit, the agent may be mixed with other ingredients or may be in a package for the agent. Typically, the food composition contains about 0.1% to about 10% prebiotics on a dry matter basis, in one embodiment about 0.3% to about 7%, and in one particular embodiment about 0.5% to 5% prebiotics. Prebiotics can be incorporated into the composition using methods known to those skilled in the art, for example, US Patent No. 5,952,033.

[0059]

[0059] One skilled in the art can determine the appropriate amounts of food ingredients, vitamins, minerals, probiotics, prebiotics, antioxidants, or other ingredients to use in making a particular composition to be administered to a particular animal. One skilled in the art can consider the species, age, size, weight, health, etc. of the animal when determining the optimal method of formulating a particular composition containing such ingredients. Other factors that can be considered include the desired dosage of each component, the average intake of a particular type of composition by various animals (e.g., based on species, weight, activity / energy requirements, etc.), and manufacturing requirements of the composition.

[0060]

[0060] In a further aspect, the present disclosure provides a kit suitable for administering a food composition to an animal. The kit includes, depending on the components of the kit, in separate containers in a single package or in separate containers in a virtual package, one or more of the following: (1) one or more ingredients suitable for consumption by an animal; (2) instructions on how to combine the ingredients with other kit components to produce a composition useful for producing the health benefits described herein; (3) instructions on how to use the food composition to obtain such benefits; (4) optionally, one or more probiotics; (5) optionally, one or more inactivated probiotics; (6) optionally, one or more components of the inactivated probiotics that promote similar or identical health benefits as the probiotics, such as proteins, lipids, glycoproteins, etc.; (7) optionally, one or more prebiotics; (8) a device for preparing or combining the kit components to produce a composition suitable for administration to an animal; and (9) a device for administering the combined or prepared kit components to an animal. In one embodiment, the kit includes one or more ingredients suitable for consumption by an animal, hi another embodiment, the kit includes instructions on how to combine the ingredients to produce a composition useful for achieving the health benefits described herein.

[0061]

[0061] When the kit includes a virtual package, the kit is limited to the instructions in a virtual environment combined with one or more physical kit components. The kit contains the components in sufficient amounts to obtain the health benefits described herein. Typically, the components of the kit can be mixed immediately prior to ingestion by the animal. The kit may include the components of the kit in any of various combinations and / or mixtures. In one embodiment, the kit includes a food container for ingestion by the animal. The kit may include additional items such as a device for mixing ingredients or a device for containing the mixture (e.g., a food bowl). In another embodiment, the food composition can be mixed with additional dietary supplements such as vitamins and minerals that promote good health in the animal. The components can each be provided in separate containers in a single package or as a mixture of various components in different packages. In some embodiments, the kit includes one or more other ingredients suitable for ingestion by the animal. In one aspect, such a kit can include instructions describing how to combine the ingredients to form a food composition for consumption by an animal, generally by mixing the ingredients or applying optional additives to other ingredients, e.g., sprinkling a dietary supplement onto the food composition.

[0062] In a further aspect, a means may be provided for communicating information or instructions regarding one or more of: (1) the use of the food composition to obtain one of the health benefits described herein; (2) contact information for the consumer to use if they have questions regarding the methods and compositions described herein; and (3) nutritional information regarding the food composition. The communication means may be useful for explaining the benefits of using the method or composition, and for communicating approved methods for administering the food composition to an animal. Such means may include one or more of a physical or electronic document, a digital storage medium, an optical storage medium, an audio presentation, an audiovisual display, or a visual display that includes such information or instructions. In one aspect, the means may be selected from the group consisting of a displayed website, a display kiosk, a pamphlet, a product label, a package insert, an advertisement, a flyer, a notice, an audiotape, a videotape, a DVD, a CD-ROM, a computer readable chip, a computer readable card, a computer readable disk, a USB device, a FireWire device, a computer memory, and any combination thereof.

[0063] In another aspect, a method for producing a food composition comprising one or more other ingredients suitable for consumption by an animal (e.g., one or more of protein, fat, carbohydrate, fiber, vitamins, minerals, probiotics, prebiotics, etc.) may comprise mixing one or more ingredients suitable for consumption by an animal. The composition may be produced according to any method suitable in the art.

[0064]

[0064] In another aspect, a package useful for containing the compositions described herein can include at least one device suitable for containing a food composition and a label affixed to the package that includes a word (or words), image, design, acronym, slogan, phrase, or other design, or combination thereof, indicating that the contents of the package include a food composition. In some embodiments, the label affixed to the package includes a word (or words), image, design, acronym, slogan, phrase, or other design, or combination thereof, indicating that the contents of the package include a food composition having beneficial properties related to health effects as described herein. In one aspect, such design can include words such as "enhance memory," "enhance trainability," "enhance learning," "enhance vision," or equivalent or similar expressions printed on the package. Any package configuration and packaging material suitable for containing the composition can be used in the present invention, such as bags, boxes, bottles, cans, pouches, etc., made from paper, plastic, foil, metal, etc. In one embodiment, the package contains a food composition tailored for a particular animal, such as a human, canine or feline, as appropriate for the label, and in one aspect, a companion animal food composition for dogs or cats. In one embodiment, the package can be a can or pouch containing the food composition described herein. In various embodiments, the package further comprises at least one window that allows the contents of the package to be viewed without opening the package. In some embodiments, the window can be a transparent portion of a packaging member. In other embodiments, the window can be a portion where no packaging member is present.

[0065] [Example]

[0065] The present invention can be further illustrated by the following examples, which are included for illustrative purposes only and, unless otherwise specified, are not intended to limit the scope of the invention.

[0066] Example 1 - Testing on puppies At baseline, 2.5-month-old puppies were randomized into two groups, with each group having 16 puppies with equal gender distribution. During the feeding study, the puppies were fed either a test diet containing a brain development blend (BDB) with elevated levels of B vitamins, taurine, choline, antioxidants (VE and VC), and omega-3 polyunsaturated fatty acids (PUFAs), specifically docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA), or a control diet for 13 months (Table 1). The control diet was a complete and balanced diet containing the essential nutrients found in the BDB at levels exceeding the AAFCO minimum requirements (Table 1). During the feeding study, the puppies were administered several cognitive tests.

[0067] [Table 1]

[0068] The results showed that both groups of puppies performed equally well in common cognitive tests assessing learning, working memory, long-term memory, associative learning, visuospatial learning, and memory, and executive function, confirming that the control diet contained sufficient nutrients to support normal brain and cognitive development. However, puppies fed the test diet performed significantly better in a complex cognitive test assessing episodic learning and memory (DNMP) when the puppies were around 6 months of age, and the effect remained when the puppies were around 15 months of age (pattern separation test) (Table 2). Furthermore, the variable landmark test showed that the BDB puppies showed significantly smaller changes in the longest distance (the most difficult test, Land 4) than those of the control puppies (Table 2). The difference between Land 0 (easiest) and Land 4 (most difficult) in the control puppies was larger than that of the BDB puppies, indicating that the control puppies handled the most difficult test (Land 4) worse than those of the BDB puppies (Table 2).

[0069] [Table 2]

[0070] The DNMP test protocol had two components: an episodic learning component and an episodic memory component. Subjects were tested Monday through Friday, one session per day, with 12 trials per session. Dogs were first trained with a 5-second delay between sample and test presentation, with 30 seconds between trials, until they passed the two-stage learning criterion, or until the end of the test period. Criteria in the 5-second DNMP followed a two-stage system: Stage 1: Dogs scored 90% or more correct in a single session, or 80% or more correct over two consecutive sessions, or three consecutive scores of 10 / 12, 8 / 12, 10 / 12, in that order. Stage 2: Dogs scored 70% or more total over three consecutive 10-trial sessions.

[0071] For the pattern separation task, each subject was tested on three separate spatial tasks, with two of the three correct locations being on the animal's left side (four locations, two cups, one cup with object under it). Training on problem 1 was conducted over the first 15 consecutive trials, problem 2 was assessed over trials 16-30, and problem 3 was assessed over trials 31-45. The intertrial interval was 15 s, and to achieve the learning criterion, subjects were required to obtain 35 / 45 correct responses in a single session and to respond correctly on a minimum of 10 trials per spatial pattern.

[0072]

[0070] In the landmark discrimination task, the visual ability of each subject was tested to find the reward using a cue from the outside world (landmark). The dog was first trained to find the cue associated with the food reward (land 0). The subject was then trained to choose the location closest to the cue after moving the cue away from the food reward. Once the two-step criterion was completed, the landmark was moved further away from the reward in 1 cm increments (land 1, 2, and 4). The subject was moved to the next location after reaching the two-step criterion at each level or until the maximum number of sessions was reached.

[0073] Subjects were tested at distances Land 0, Land 1, and Land 4 and moved to the next distance level after meeting the following criteria: Tier 1: Dogs scored 90% or more correct in a single session or 80% or more correct over two consecutive sessions. Tier 2: Dogs scored 70% or more total over three consecutive 10 trial sessions.

[0074] During the feeding trials, the puppies were also subjected to several clicker training tasks to evaluate their real-life-like trainability. Target Tough training assessed the trainability of the puppies with language comprehension. The trainability tests included the following: Trial 1 - The dog touches the target object with its nose when a "touch" cue is given. Trial 2 - The target object is held within reach of the dog and the dog is made to wait one meter in front of the trainer. When a "touch" cue is given, the dog touches the target object with its nose. Trial 3 - The target object is held six inches above the dog's head and the dog stands on its hind legs and touches the target object with its nose when a "touch" cue is given. Trial 4 - The target object is held within reach of the dog and the dog is made to wait in front of the trainer. When a "touch" cue is given, the dog touches the target object with its nose and holds it for two seconds. The results are expressed as % correct responses to pass the task and are shown in Table 3.

[0075] [Table 3]

[0076] The results showed that BDB puppies performed better than control puppies in Trials 1 and 2, and performed significantly better in Trial 4, the most difficult of the target-touch training tasks. These results are consistent with the better performance observed in BDB puppies than control puppies in complex cognitive tests.

[0077]

[0074] Specific embodiments of the present invention are disclosed herein. Although specific terms are used, they are used generically and for descriptive purposes only and are not intended to be limiting. The scope of the present invention is defined in the claims. Obviously, many modifications and variations of the present invention are possible in light of the above teachings. It is therefore understood that within the scope of the appended claims, the present invention may be practiced otherwise than as specifically described. The present invention may be in the following form. Item 1 1. A method for providing a health benefit to a growing animal, comprising administering to said animal a food composition comprising: Approximately 10 mg / day to approximately 3,000 mg / day of DHA, EPA from about 10 mg / day to about 3000 mg / day Taurine, about 50mg / day to about 2000mg / day About 50 mg / day to about 2000 mg / day of choline, Thiamine, about 0.1 mg / day to about 50 mg / day About 0.1 mg / day to about 50 mg / day of riboflavin, Pantothenic acid, from about 0.1 mg / day to about 100 mg / day Niacin, about 0.1 mg / day to about 250 mg / day About 0.1 mg / day to about 50 mg / day of pyridoxine, About 0.1 μg / day to about 1000 μg / day of vitamin B12, and About 0.01 mg / day to about 15 mg / day of folic acid, is administered in an amount that provides The method, wherein the health effect is selected from the group consisting of enhanced brain and cognitive development, improved trainability, improved episodic learning, improved episodic memory, reduced spherical aberration of the eye, enhanced photopic vision, and combinations thereof. Item 2 The food composition comprises: Approximately 15% to 70% protein, Approximately 5% to 50% carbohydrates, About 5% to about 40% fat, Approximately 100 mg / kg to approximately 3000 mg / kg of DHA, EPA of about 100 mg / kg to about 3000 mg / kg, Taurine from about 100 mg / kg to about 5000 mg / kg, Choline from about 100 mg / kg to about 6000 mg / kg, Thiamine from about 1 mg / kg to about 150 mg / kg, about 1 mg / kg to about 100 mg / kg of riboflavin, about 1 mg / kg to about 250 mg / kg of pantothenic acid, Niacin from about 1 mg / kg to about 600 mg / kg, about 1 mg / kg to about 100 mg / kg pyridoxine, About 0.01 mg / kg to about 5 mg / kg of vitamin B12, and About 0.1 mg / kg to about 50 mg / kg of folic acid, The method according to item 1, comprising: Item 3 The food composition is a dietary supplement comprising a brain development blend, the brain development blend comprising: Approximately 50g / kg to approximately 350g / kg of DHA, EPA at about 50g / kg to about 350g / kg, Taurine, about 50g / kg to about 350g / kg Choline from about 50 g / kg to about 400 g / kg, Thiamine from about 0.1 g / kg to about 50 g / kg, About 0.1 g / kg to about 50 g / kg of riboflavin, Pantothenic acid from about 0.1 g / kg to about 50 g / kg, Niacin, about 1g / kg to about 50g / kg About 0.1 g / kg to about 50 g / kg of pyridoxine, About 0.001 g / kg to about 10 g / kg of vitamin B12, and About 0.01g / kg to about 10g / kg of folic acid, The method according to item 1, comprising: Item 4 2. The method according to claim 1, wherein the food composition is administered to the animal periodically. Item 5 2. The method according to claim 1, wherein the food composition is a pet food composition. Item 6 2. The method of claim 1, wherein the animal is a companion animal. Item 7 2. The method according to claim 1, wherein the food composition further comprises vitamin E and vitamin C. Item 8 2. The method of claim 1, wherein the health benefit is a reduction in ocular spherical aberration, an enhancement of photopic vision, or a combination thereof. Item 9 2. The method of claim 1, wherein the health effect is enhanced brain and cognitive development, improved trainability, improved episodic learning, improved episodic memory, or a combination thereof. Item 10 1. A food composition for a growing animal, the food composition comprising a brain development blend, the brain development blend comprising: Approximately 5% to 35% DHA, Approximately 5% to 35% EPA, About 5% to about 35% taurine, About 5% to about 40% choline, Thiamine, about 0.01% to about 5% About 0.01% to about 5% riboflavin, Approximately 0.01% to approximately 5% pantothenic acid, Approximately 0.1% to 5% niacin, About 0.01% to about 5% pyridoxine, About 0.0001% to about 1% Vitamin B12, and Contains about 0.001% to about 1% folic acid, The food composition contains an effective amount of the brain development blend sufficient to provide a health effect selected from the group consisting of enhanced brain and cognitive development, improved trainability, improved episodic learning, improved episodic memory, reduced ocular spherical aberration, enhanced photopic vision, and combinations thereof. Item 11 The food composition comprises: Approximately 15% to 70% protein, Approximately 5% to 50% carbohydrates, About 5% to about 40% fat, Approximately 100 mg / kg to approximately 3000 mg / kg of DHA, EPA of about 100 mg / kg to about 3000 mg / kg, Taurine from about 100 mg / kg to about 5000 mg / kg, Choline from about 100 mg / kg to about 6000 mg / kg, Thiamine from about 1 mg / kg to about 150 mg / kg, about 1 mg / kg to about 100 mg / kg of riboflavin, about 1 mg / kg to about 250 mg / kg of pantothenic acid, Niacin from about 1 mg / kg to about 600 mg / kg, about 1 mg / kg to about 100 mg / kg pyridoxine, About 0.01 mg / kg to about 5 mg / kg of vitamin B12, and About 0.1 mg / kg to about 50 mg / kg of folic acid, 11. The food composition according to Item 10, comprising: Item 12 The food composition is a dietary supplement comprising the brain development blend, the brain development blend comprising: Approximately 50g / kg to approximately 350g / kg of DHA, EPA at about 50g / kg to about 350g / kg, Taurine, about 50g / kg to about 350g / kg Choline from about 50 g / kg to about 400 g / kg, Thiamine from about 0.1 g / kg to about 50 g / kg, About 0.1 g / kg to about 50 g / kg of riboflavin, Pantothenic acid from about 0.1 g / kg to about 50 g / kg, Niacin, about 1g / kg to about 50g / kg About 0.1 g / kg to about 50 g / kg of pyridoxine, About 0.001 g / kg to about 10 g / kg of vitamin B12, and About 0.01g / kg to about 10g / kg of folic acid, Item 11. The food composition according to Item 10, comprising: Item 13 Item 11. The food composition according to item 10, wherein the food composition is a pet food composition. Item 14 11. The food composition according to item 10, wherein the animal is a companion animal. Item 15 Item 11. The food composition according to item 10, further comprising vitamin E and vitamin C.

Claims

1. 1. A method for providing a health benefit to a growing animal, comprising administering to said animal a food composition, The food composition comprises, based on weight of the food composition on a dry matter basis, 15% to 70% protein, 5% to 50% carbohydrates, 5% to 40% fat, 1500 mg / kg to 2500 mg / kg DHA, EPA from 1500 mg / kg to 2500 mg / kg, 1000 mg / kg to 4000 mg / kg of taurine, 2000 mg / kg to 3000 mg / kg choline, 30 mg / kg to 80 mg / kg thiamine, 10 mg / kg to 30 mg / kg riboflavin, 25 mg / kg to 75 mg / kg pantothenic acid, 100 mg / kg to 300 mg / kg niacin, 10 mg / kg to 20 mg / kg pyridoxine, 0.1 mg / kg to 1 mg / kg of vitamin B12, and 1 mg / kg to 10 mg / kg of folic acid, Including, The food composition comprises: 140 mg / day to 500 mg / day of DHA, 140 mg / day to 500 mg / day of EPA, 100 mg / day to 1000 mg / day of taurine, 180 mg / day to 700 mg / day of choline, 1.5 mg / day to 12.5 mg / day of thiamine, 1.5 mg / day to 10 mg / day of riboflavin, 1.5 mg / day to 25 mg / day of pantothenic acid, 10 mg / day to 50 mg / day of niacin, 1 mg / day to 10 mg / day of pyridoxine, 1 μg / day to 150 μg / day of vitamin B12, and 0.2 mg / day to 5 mg / day of folic acid, is administered in an amount that provides the health benefits are selected from the group consisting of enhanced brain and cognitive development, improved trainability, improved episodic learning, improved episodic memory, and combinations thereof; The method, wherein the animal is a dog.

2. The method of claim 1 , wherein the food composition is administered to the animal on a regular basis.

3. The method of claim 1 or 2, wherein the food composition is a pet food composition.

4. The method of any one of claims 1 to 3, wherein the animal is a companion animal.

5. The method according to any one of claims 1 to 4, wherein the food composition further comprises vitamin E and vitamin C.

6. A food composition for providing a health benefit to a growing animal, comprising: The food composition comprises, based on weight of the food composition on a dry matter basis, 15% to 70% protein, 5% to 50% carbohydrates, 5% to 40% fat, 1500 mg / kg to 2500 mg / kg DHA, EPA from 1500 mg / kg to 2500 mg / kg, 1000 mg / kg to 4000 mg / kg of taurine, 2000 mg / kg to 3000 mg / kg choline, 30 mg / kg to 80 mg / kg thiamine, 10 mg / kg to 30 mg / kg riboflavin, 25 mg / kg to 75 mg / kg pantothenic acid, 100 mg / kg to 300 mg / kg niacin, 10 mg / kg to 20 mg / kg pyridoxine, 0.1 mg / kg to 1 mg / kg of vitamin B12, and 1 mg / kg to 10 mg / kg of folic acid, Including, The food composition is administered to the animal. 140 mg / day to 500 mg / day of DHA, 140 mg / day to 500 mg / day of EPA, 100 mg / day to 1000 mg / day of taurine, 180 mg / day to 700 mg / day of choline, 1.5 mg / day to 12.5 mg / day of thiamine, 1.5 mg / day to 10 mg / day of riboflavin, 1.5 mg / day to 25 mg / day of pantothenic acid, 10 mg / day to 50 mg / day of niacin, 1 mg / day to 10 mg / day of pyridoxine, 1 μg / day to 150 μg / day of vitamin B12, and 0.2 mg / day to 5 mg / day of folic acid, is administered in an amount that provides the health benefits are selected from the group consisting of enhanced brain and cognitive development, improved trainability, improved episodic learning, improved episodic memory, and combinations thereof; The food composition, wherein the animal is a dog.

7. The food composition comprises a brain development blend, the brain development blend comprising, by weight on a dry matter basis of the brain development blend: 5% to 35% DHA, EPA between 5% and 35%; 5% to 35% taurine, 5% to 40% choline, 0.01% to 5% thiamine, 0.01% to 5% riboflavin, 0.01% to 5% pantothenic acid, 0.1% to 5% niacin, 0.01% to 5% pyridoxine, 0.0001% to 1% Vitamin B12, and 7. The food composition of claim 6, comprising 0.001% to 1% folic acid.

8. The food composition is a dietary supplement comprising a brain development blend, the brain development blend comprising, by weight on a dry matter basis of the brain development blend: DHA from 50 g / kg to 350 g / kg, EPA from 50 g / kg to 350 g / kg, 50 g / kg to 350 g / kg of taurine, 50 g / kg to 400 g / kg choline, 0.1 g / kg to 50 g / kg thiamine, 0.1 g / kg to 50 g / kg riboflavin, 0.1 g / kg to 50 g / kg of pantothenic acid, 1 g / kg to 50 g / kg niacin, 0.1 g / kg to 50 g / kg pyridoxine, 0.001 g / kg to 10 g / kg of vitamin B12, and 0.01 g / kg to 10 g / kg of folic acid, The food composition according to claim 6 or 7, comprising:

9. The food composition according to any one of claims 6 to 8, wherein the food composition is a pet food composition.

10. The food composition according to any one of claims 6 to 9, wherein the animal is a companion animal.

11. The food composition according to any one of claims 6 to 10, further comprising vitamin E and vitamin C.

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