Compounds for Treating Huntington's Disease

Abstract

This specification relates to compounds, forms thereof, and pharmaceutical compositions, as well as methods of using such compounds, forms thereof, or compositions for treating or ameliorating Huntington's disease. In particular, this specification relates to substituted monocyclic heteroaryl compounds of Formula (I), Formula (II), or Formula (III), forms thereof, and pharmaceutical compositions, as well as methods of using such compounds, forms thereof, or compositions for treating or ameliorating Huntington's disease. [Formula 1] TIFF2022533120000108.tif41164

Description

[Technical field]

[0001] CROSS-REFERENCE TO RELATED APPLICATIONS This application claims priority to U.S. Provisional Application No. 62 / 846,896, filed May 13, 2019, the contents of which are incorporated herein by reference.

[0002] Aspects of the present specification relate to compounds, forms thereof and pharmaceutical compositions useful for treating or ameliorating Huntington's disease, as well as methods of using such compounds, forms thereof or compositions. In particular, another aspect of the present specification relates to substituted monocyclic heteroaryl compounds, forms thereof and pharmaceutical compositions, as well as methods of using such compounds, forms thereof or compositions for treating or ameliorating Huntington's disease. [Background technology]

[0003] Huntington's disease (HD) is a progressive autosomal dominant neurodegenerative disorder of the brain with symptoms characterized by involuntary movements, cognitive impairment, and mental decline. Death is typically caused by pneumonia or coronary artery disease and usually occurs 13-15 years after the onset of symptoms. The prevalence of HD is 3-7 per 100,000 in populations of Western European descent. In North America, an estimated 30,000 people have HD, with an additional 200,000 at risk of inheriting the disease from an affected parent. The disease is caused by an expansion of consecutive trinucleotide CAG repeats in the "mutated" huntingtin (Htt) gene, which produces HTT (Htt protein) that contains an expansion of poly-glutamine (polyQ) stretches, also known as "CAG repeat" sequences. None of the current small molecule therapeutics targets the underlying cause of the disease, and there remains a high unmet need for drugs that can be used to treat or ameliorate HD. As a result, there remains a need to identify and provide small molecule compounds for treating or ameliorating HD.

[0004] All other documents referred to herein are incorporated by reference into this application as if fully set forth herein. Summary of the Invention

[0005] Embodiments herein include compounds of Formula (I), Formula (II), or Formula (III), or compounds comprising forms thereof. [ka] (Wherein, X, B, and R 1 are defined herein) Embodiments herein include a method for treating or ameliorating HD in a subject in need thereof comprising administering to the subject an effective amount of a compound of Formula (I), Formula (II), or Formula (III), or a form thereof.

[0006] Embodiments herein include methods of using a compound of Formula (I), Formula (II), or Formula (III), or a form or composition thereof, to treat or ameliorate HD in a subject in need thereof comprising administering to the subject an effective amount of a compound of Formula (I), Formula (II), or Formula (III), or a form or composition thereof.

[0007] Aspects herein include the use of a compound of Formula (I), Formula (II), or Formula (III), or a form thereof, for treating or ameliorating HD in a subject in need thereof, comprising administering to the subject an effective amount of a compound of Formula (I), Formula (II), or Formula (III), or a form thereof.

[0008] Aspects herein include the use of a compound of Formula (I), Formula (II), or Formula (III), or a form thereof, in the manufacture of a medicament for treating or ameliorating HD in a subject in need thereof, comprising administering an effective amount of the medicament to the subject.

[0009] Aspects herein include the use of a compound of Formula (I), Formula (II), or Formula (III), or a form thereof, in a combination product with one or more therapeutic agents to treat or ameliorate HD in a subject in need thereof comprising administering to the subject an effective amount of a compound of Formula (I), Formula (II), or Formula (III), or a form thereof, in combination with an effective amount of the one or more agents. DETAILED DESCRIPTION OF THE PREFERRED EMBODIMENTS

[0010] An aspect of the present specification relates to a compound of Formula (I), Formula (II), or Formula (III), or a compound comprising a form thereof, wherein the form of the compound is selected from the group consisting of a salt, a hydrate, a solvate, a racemate, an enantiomer, a diastereoisomer, a tautomer, and a mixture thereof. [ka] (In the formula, X is O, NR x , or a bond, R x is hydrogen and C 1-4 alkyl, B is heterocyclyl; Heterocyclyl is a saturated or partially unsaturated 3- to 7-membered monocyclic, 6- to 10-membered bicyclic, or 13- to 16-membered polycyclic ring system having 1, 2, or 3 heteroatom ring members independently selected from N, O, or S, and, where permitted by available valences, 1, 2, 3, 4, or 5 R b may be substituted with a substituent; R b is a halogen, C 1-4 Alkyl, Amino, C 1-4 Alkyl-amino, (C 1-4 Alkyl) 2 -amino, and C 3-6 cycloalkyl; R 1 Heteroaryl, heterocyclyl, phenyl, heteroaryl-C 1-4Alkyl, Heteroaryl-C 2-4 Alkenyl, Heteroaryl-amino, and Heteroaryl-C 1-4 alkyl-amino; Heteroaryl is a 3-7 membered monocyclic or 6-10 membered bicyclic ring system having 1, 2, 3, or 4 heteroatom ring members independently selected from N, O, or S; Heterocyclyl is a saturated or partially unsaturated 3- to 7-membered monocyclic, 6- to 10-membered bicyclic or 13- to 16-membered polycyclic ring system having 1, 2 or 3 heteroatom ring members independently selected from N, O or S; Each example of phenyl, heteroaryl, or heterocyclyl may have one or two R 1a may be substituted with a substituent; R 1a is halogen, hydroxyl, cyano, C 1-4 Alkyl, Deuterium-C 1-4 Alkyl, halo-C 1-4 Alkyl, Amino, C 1-4 Alkyl-amino, (C 1-4 Alkyl) 2 - Amino, C 1-4 Alkoxy, Deuterium-C 1-4 Alkoxy, and halo-C 1-4 alkoxy)

[0011] Aspects of the present specification Aspects of the present specification relate to compounds of Formula (I), Formula (II), or Formula (III), or compounds comprising forms thereof. [ka] (In the formula, X is O, NR x , or a bond, R x is hydrogen and C 1-4 alkyl, B is heterocyclyl; Heterocyclyl is a saturated or partially unsaturated 3- to 7-membered monocyclic, 6- to 10-membered bicyclic, or 13- to 16-membered polycyclic ring system having 1, 2, or 3 heteroatom ring members independently selected from N, O, or S, and, where permitted by available valences, 1, 2, 3, 4, or 5 R b may be substituted with a substituent; R b is a halogen, C 1-4 Alkyl, Amino, C 1-4 Alkyl-amino, (C 1-4 Alkyl) 2 -Amino and C 3-6 cycloalkyl; R 1 Heteroaryl, heterocyclyl, phenyl, heteroaryl-C 1-4 Alkyl, Heteroaryl-C 2-4 Alkenyl, Heteroaryl-amino, and Heteroaryl-C 1-4 alkyl-amino; Heteroaryl is a 3-7 membered monocyclic or 6-10 membered bicyclic ring system having 1, 2, 3, or 4 heteroatom ring members independently selected from N, O, or S; Heterocyclyl is a saturated or partially unsaturated 3- to 7-membered monocyclic, 6- to 10-membered bicyclic or 13- to 16-membered polycyclic ring system having 1, 2 or 3 heteroatom ring members independently selected from N, O or S; Each example of phenyl, heteroaryl, or heterocyclyl may have one or two R 1a may be substituted with a substituent; R 1a is halogen, hydroxyl, cyano, C 1-4 Alkyl, Deuterium-C 1-4 Alkyl, halo-C 1-4 Alkyl, Amino, C 1-4 Alkyl-amino, (C 1-4 Alkyl) 2 - Amino, C 1-4 Alkoxy, Deuterium-C 1-4 Alkoxy, and halo-C 1-4alkoxy)

[0012] In one embodiment, X is O, NR x and a bond.

[0013] Another embodiment includes compounds of formula (I), formula (II), or formula (III) where X is O.

[0014] Another embodiment is where X is NR x

[0033] The present invention includes compounds of formula (I), formula (II), or formula (III),

[0015] Another embodiment includes compounds of formula (I), formula (II), or formula (III) where X is a bond.

[0016] In one embodiment, R x But hydrogen and C 1-4 The present invention includes compounds of formula (I), formula (II), or formula (III) wherein the alkyl is selected from the group consisting of aryl, aryl, aryl and alkyl.

[0017] Another aspect is R x is hydrogen.

[0018] Another aspect is R x is selected from methyl, ethyl, propyl, isopropyl, butyl, and tert-butyl; 1-4 This includes compounds of formula (I), formula (II), or formula (III) in which:

[0019] Another aspect is R x is methyl.

[0020] In one embodiment, B is heterocyclyl, which is a saturated or partially unsaturated 3-7 membered monocyclic, 6-10 membered bicyclic, or 13-16 membered polycyclic ring system having 1, 2, or 3 heteroatom ring members independently selected from N, O, or S, and, where permitted by available valences, 1, 2, 3, 4, or 5 R b This includes compounds of formula (I), formula (II), or formula (III) which may be substituted with a substituent.

[0021] Another embodiment includes compounds of Formula (I), Formula (II), or Formula (III) where B is unsubstituted heterocyclyl, which is a saturated or partially unsaturated 3-7 membered monocyclic, 6-10 membered bicyclic, or 13-16 membered polycyclic ring system having 1, 2, or 3 heteroatom ring members independently selected from N, O, or S.

[0022] Another embodiment is where B is heterocyclyl, which is a saturated or partially unsaturated 3-7 membered monocyclic, 6-10 membered bicyclic, or 13-16 membered polycyclic ring system having 1, 2, or 3 heteroatom ring members independently selected from N, O, or S, and, where permitted by available valences, one R b This includes compounds of formula (I), formula (II), or formula (III) which are substituted with a substituent.

[0023] Another embodiment is where B is heterocyclyl, which is a saturated or partially unsaturated 3-7 membered monocyclic, 6-10 membered bicyclic, or 13-16 membered polycyclic ring system having 1, 2, or 3 heteroatom ring members independently selected from N, O, or S, and where available valences permit, two R b Includes compounds of formula (I), formula (II), or formula (III), each of which is substituted with a substituent.

[0024] Another embodiment is where B is heterocyclyl, which is a saturated or partially unsaturated 3-7 membered monocyclic, 6-10 membered bicyclic, or 13-16 membered polycyclic ring system having 1, 2, or 3 heteroatom ring members independently selected from N, O, or S, and, where permitted by available valences, three R b This includes compounds of formula (I), formula (II), or formula (III) which are substituted with a substituent.

[0025] Another embodiment is where B is heterocyclyl, which is a saturated or partially unsaturated 3-7 membered monocyclic, 6-10 membered bicyclic, or 13-16 membered polycyclic ring system having 1, 2, or 3 heteroatom ring members independently selected from N, O, or S, and, where permitted by available valences, four R b This includes compounds of formula (I), formula (II), or formula (III) which are substituted with a substituent.

[0026] Another embodiment is where B is heterocyclyl, which is a saturated or partially unsaturated 3-7 membered monocyclic, 6-10 membered bicyclic, or 13-16 membered polycyclic ring system having 1, 2, or 3 heteroatom ring members independently selected from N, O, or S, and where available valences permit, five R b This includes compounds of formula (I), formula (II), or formula (III) which are substituted with a substituent.

[0027] Another embodiment is where B is azetidinyl, tetrahydrofuranyl, pyrrolidinyl, piperidinyl, piperidin-1-olate-yl, piperazinyl, 1,4-diazepanyl, 1,2-dihydropyridinyl, 1,2,5,6-tetrahydropyridinyl, 1,2,3,6-tetrahydropyridinyl, hexahydrocyclopentapyrrol-(1H)-yl, hexahydropyrrolo[3,2-b]pyrrol-(2H)-yl, hexahydropyrrolo[3,4-b]pyrrol-(2H)-yl, octahydro-2H-pyrrolo[3,4-c]pyridinyl, octahydro-5H- Pyrrolo[3,2-c]pyridinyl, octahydro-6H-pyrrolo[3,4-b]pyridinyl, hexahydropyrrolo[1,2-a]pyrazin-(2H)-one, hexahydropyrrolo[1,2-a]pyrazin-(1H)-yl, hexahydro-1H-cyclobuta[1.2-c:1,4-c′]dipyrrol-(3H)-yl, octahydropyrrolo[1,2-a]pyrazin-(1H)-yl, octahydro-2H-pyrido[1,2-a]pyrazinyl, hexahydropyrrolo[3,4-b][1,4]oxazin-(2H)-yl, 5-azaspiro[2.4]hepta nyl, 1-azaspiro[3.3]heptanyl, 4-azaspiro[2.5]octanyl, 2-oxa-6-azaspiro[3.4]octanyl, 3-azabicyclo[3.1.0]hexanyl, 8-azabicyclo[3.2.1]octanyl, 8-azabicyclo[3.2.1]oct-2-en-yl, 9-azabicyclo[3.3.1]nonanyl, 2,5-diazabicyclo[2.2.1]heptanyl, 1,4-diazabicyclo[3.1.1]heptanyl, 3,6-diazabicyclo[3.2.0]heptanyl, 2,5-diazabicyclo[2.2.2]octanyl, 1,4-diazabicyclo[3.2.1]octanyl, 3,8-diazabicyclo[3.2.1]octanyl, 1,4-diazabicyclo[3.2.2]nonanyl, 4,7-diazaspiro[2.5]octanyl, 2,6-diazaspiro[3.3]heptanyl, 1,6-diazaspiro[3.4]octanyl, 2,6-diazaspiro[3.4]octanyl, 1,7-diazaspiro[4.4]nonanyl, 1,7-diazaspiro[3.5]nonanyl, 2,6-diazaspiro[3.5]nonanyl, 2,7-diazaspiro[3.5]nonanyl, 5,8-diazaspiro[3.5]nonanyl, 2-oxa-5,8-diazaspiro[3.5]nonanyl, 2,7-diazaspiro[4.4]nonanyl, 2,7-diazaspiro[4.5]decanyl, 2,8-diazaspiro[4.5]decanyl, 6,9-diazaspiro[4.5]decyl, 6-oxa-2,9-diazaspiro[4.5]decanyl, 2,9-diazaspiro[5.5]undecanyl, 4-azadispiro[2.1.2. 5 .3 3 ]decanyl, and 7-azadispiro[5.1.5 8 .3 6 ]hexadecanyl, where available valences permit, one, two, three, four or five R b This includes compounds of formula (I), formula (II), or formula (III) which may be substituted with a substituent.

[0028] Another embodiment is where B is azetidinyl, tetrahydrofuranyl, pyrrolidinyl, piperidinyl, piperidin-1-olate-yl, piperazinyl, 1,4-diazepanyl, 1,2-dihydropyridinyl, 1,2,5,6-tetrahydropyridinyl, 1,2,3,6-tetrahydropyridinyl, hexahydrocyclopentapyrrol-(1H)-yl, hexahydropyrrolo[3,2-b]pyrrol-(2H)-yl, hexahydropyrrolo[3,4-b]pyrrol-(2H)-yl, octahydro-2H-pyrrolo[3,4-c]pyridinyl, octahydro-5H- Pyrrolo[3,2-c]pyridinyl, octahydro-6H-pyrrolo[3,4-b]pyridinyl, hexahydropyrrolo[1,2-a]pyrazin-(2H)-one, hexahydropyrrolo[1,2-a]pyrazin-(1H)-yl, hexahydro-1H-cyclobuta[1.2-c:1,4-c′]dipyrrol-(3H)-yl, octahydropyrrolo[1,2-a]pyrazin-(1H)-yl, octahydro-2H-pyrido[1,2-a]pyrazinyl, hexahydropyrrolo[3,4-b][1,4]oxazin-(2H)-yl, 5-azaspiro[2.4]hepta nyl, 1-azaspiro[3.3]heptanyl, 4-azaspiro[2.5]octanyl, 2-oxa-6-azaspiro[3.4]octanyl, 3-azabicyclo[3.1.0]hexanyl, 8-azabicyclo[3.2.1]octanyl, 8-azabicyclo[3.2.1]oct-2-en-yl, 9-azabicyclo[3.3.1]nonanyl, 2,5-diazabicyclo[2.2.1]heptanyl, 1,4-diazabicyclo[3.1.1]heptanyl, 3,6-diazabicyclo[3.2.0]heptanyl, 2,5-diazabicyclo[2.2.2]octanyl, 1,4-diazabicyclo[3.2.1]octanyl, 3,8-diazabicyclo[3.2.1]octanyl, 1,4-diazabicyclo[3.2.2]nonanyl, 4,7-diazaspiro[2.5]octanyl, 2,6-diazaspiro[3.3]heptanyl, 1,6-diazaspiro[3.4]octanyl, 2,6-diazaspiro[3.4]octanyl, 1,7-diazaspiro[4.4]nonanyl, 1,7-diazaspiro[3.5]nonanyl, 2,6-diazaspiro[3.5]nonanyl, 2,7-diazaspiro[3.5]nonanyl, 5,8-diazaspiro[3.5]nonanyl, 2-oxa-5,8-diazaspiro[3.5]nonanyl, 2,7-diazaspiro[4.4]nonanyl, 2,7-diazaspiro[4.5]decanyl, 2,8-diazaspiro[4.5]decanyl, 6,9-diazaspiro[4.5]decyl, 6-oxa-2,9-diazaspiro[4.5]decanyl, 2,9-diazaspiro[5.5]undecanyl, 4-azadispiro[2.1.2. 5 .3 3 ]decanyl, and 7-azadispiro[5.1.5 8 .3 6 ]hexadecanyl.

[0029] Another embodiment is where B is azetidinyl, tetrahydrofuranyl, pyrrolidinyl, piperidinyl, piperidin-1-olate-yl, piperazinyl, 1,4-diazepanyl, 1,2-dihydropyridinyl, 1,2,5,6-tetrahydropyridinyl, 1,2,3,6-tetrahydropyridinyl, hexahydrocyclopentapyrrol-(1H)-yl, hexahydropyrrolo[3,2-b]pyrrol-(2H)-yl, hexahydropyrrolo[3,4-b]pyrrol-(2H)-yl, octahydro-2H-pyrrolo[3,4-c]pyridinyl, octahydro-5H- Pyrrolo[3,2-c]pyridinyl, octahydro-6H-pyrrolo[3,4-b]pyridinyl, hexahydropyrrolo[1,2-a]pyrazin-(2H)-one, hexahydropyrrolo[1,2-a]pyrazin-(1H)-yl, hexahydro-1H-cyclobuta[1.2-c:1,4-c′]dipyrrol-(3H)-yl, octahydropyrrolo[1,2-a]pyrazin-(1H)-yl, octahydro-2H-pyrido[1,2-a]pyrazinyl, hexahydropyrrolo[3,4-b][1,4]oxazin-(2H)-yl, 5-azaspiro[2.4]hepta nyl, 1-azaspiro[3.3]heptanyl, 4-azaspiro[2.5]octanyl, 2-oxa-6-azaspiro[3.4]octanyl, 3-azabicyclo[3.1.0]hexanyl, 8-azabicyclo[3.2.1]octanyl, 8-azabicyclo[3.2.1]oct-2-en-yl, 9-azabicyclo[3.3.1]nonanyl, 2,5-diazabicyclo[2.2.1]heptanyl, 1,4-diazabicyclo[3.1.1]heptanyl, 3,6-diazabicyclo[3.2.0]heptanyl, 2,5-diazabicyclo[2.2.2]octanyl, 1,4-diazabicyclo[3.2.1]octanyl, 3,8-diazabicyclo[3.2.1]octanyl, 1,4-diazabicyclo[3.2.2]nonanyl, 4,7-diazaspiro[2.5]octanyl, 2,6-diazaspiro[3.3]heptanyl, 1,6-diazaspiro[3.4]octanyl, 2,6-diazaspiro[3.4]octanyl, 1,7-diazaspiro[4.4]nonanyl, 1,7-diazaspiro[3.5]nonanyl, 2,6-diazaspiro[3.5]nonanyl, 2,7-diazaspiro[3.5]nonanyl, 5,8-diazaspiro[3.5]nonanyl, 2-oxa-5,8-diazaspiro[3.5]nonanyl, 2,7-diazaspiro[4.4]nonanyl, 2,7-diazaspiro[4.5]decanyl, 2,8-diazaspiro[4.5]decanyl, 6,9-diazaspiro[4.5]decyl, 6-oxa-2,9-diazaspiro[4.5]decanyl, 2,9-diazaspiro[5.5]undecanyl, 4-azadispiro[2.1.2. 5 .3 3 ]decanyl, and 7-azadispiro[5.1.5 8 .3 6 ]hexadecanyl, where available valences permit, one R b This includes compounds of formula (I), formula (II), or formula (III) which are substituted with a substituent.

[0030] Another embodiment is where B is azetidinyl, tetrahydrofuranyl, pyrrolidinyl, piperidinyl, piperidin-1-olate-yl, piperazinyl, 1,4-diazepanyl, 1,2-dihydropyridinyl, 1,2,5,6-tetrahydropyridinyl, 1,2,3,6-tetrahydropyridinyl, hexahydrocyclopentapyrrol-(1H)-yl, hexahydropyrrolo[3,2-b]pyrrol-(2H)-yl, hexahydropyrrolo[3,4-b]pyrrol-(2H)-yl, octahydro-2H-pyrrolo[3,4-c]pyridinyl, octahydro-5H- Pyrrolo[3,2-c]pyridinyl, octahydro-6H-pyrrolo[3,4-b]pyridinyl, hexahydropyrrolo[1,2-a]pyrazin-(2H)-one, hexahydropyrrolo[1,2-a]pyrazin-(1H)-yl, hexahydro-1H-cyclobuta[1.2-c:1,4-c′]dipyrrol-(3H)-yl, octahydropyrrolo[1,2-a]pyrazin-(1H)-yl, octahydro-2H-pyrido[1,2-a]pyrazinyl, hexahydropyrrolo[3,4-b][1,4]oxazin-(2H)-yl, 5-azaspiro[2.4]hepta nyl, 1-azaspiro[3.3]heptanyl, 4-azaspiro[2.5]octanyl, 2-oxa-6-azaspiro[3.4]octanyl, 3-azabicyclo[3.1.0]hexanyl, 8-azabicyclo[3.2.1]octanyl, 8-azabicyclo[3.2.1]oct-2-en-yl, 9-azabicyclo[3.3.1]nonanyl, 2,5-diazabicyclo[2.2.1]heptanyl, 1,4-diazabicyclo[3.1.1]heptanyl, 3,6-diazabicyclo[3.2.0]heptanyl, 2,5-diazabicyclo[2.2.2]octanyl, 1,4-diazabicyclo[3.2.1]octanyl, 3,8-diazabicyclo[3.2.1]octanyl, 1,4-diazabicyclo[3.2.2]nonanyl, 4,7-diazaspiro[2.5]octanyl, 2,6-diazaspiro[3.3]heptanyl, 1,6-diazaspiro[3.4]octanyl, 2,6-diazaspiro[3.4]octanyl, 1,7-diazaspiro[4.4]nonanyl, 1,7-diazaspiro[3.5]nonanyl, 2,6-diazaspiro[3.5]nonanyl, 2,7-diazaspiro[3.5]nonanyl, 5,8-diazaspiro[3.5]nonanyl, 2-oxa-5,8-diazaspiro[3.5]nonanyl, 2,7-diazaspiro[4.4]nonanyl, 2,7-diazaspiro[4.5]decanyl, 2,8-diazaspiro[4.5]decanyl, 6,9-diazaspiro[4.5]decyl, 6-oxa-2,9-diazaspiro[4.5]decanyl, 2,9-diazaspiro[5.5]undecanyl, 4-azadispiro[2.1.2. 5 .3 3 ]decanyl, and 7-azadispiro[5.1.5 8 .3 6 ]hexadecanyl, where available valences permit, two R b This includes compounds of formula (I), formula (II), or formula (III) which are substituted with a substituent.

[0031] Another embodiment is where B is azetidinyl, tetrahydrofuranyl, pyrrolidinyl, piperidinyl, piperidin-1-olate-yl, piperazinyl, 1,4-diazepanyl, 1,2-dihydropyridinyl, 1,2,5,6-tetrahydropyridinyl, 1,2,3,6-tetrahydropyridinyl, hexahydrocyclopentapyrrol-(1H)-yl, hexahydropyrrolo[3,2-b]pyrrol-(2H)-yl, hexahydropyrrolo[3,4-b]pyrrol-(2H)-yl, octahydro-2H-pyrrolo[3,4-c]pyridinyl, octahydro-5H- Pyrrolo[3,2-c]pyridinyl, octahydro-6H-pyrrolo[3,4-b]pyridinyl, hexahydropyrrolo[1,2-a]pyrazin-(2H)-one, hexahydropyrrolo[1,2-a]pyrazin-(1H)-yl, hexahydro-1H-cyclobuta[1.2-c:1,4-c′]dipyrrol-(3H)-yl, octahydropyrrolo[1,2-a]pyrazin-(1H)-yl, octahydro-2H-pyrido[1,2-a]pyrazinyl, hexahydropyrrolo[3,4-b][1,4]oxazin-(2H)-yl, 5-azaspiro[2.4]hepta nyl, 1-azaspiro[3.3]heptanyl, 4-azaspiro[2.5]octanyl, 2-oxa-6-azaspiro[3.4]octanyl, 3-azabicyclo[3.1.0]hexanyl, 8-azabicyclo[3.2.1]octanyl, 8-azabicyclo[3.2.1]oct-2-en-yl, 9-azabicyclo[3.3.1]nonanyl, 2,5-diazabicyclo[2.2.1]heptanyl, 1,4-diazabicyclo[3.1.1]heptanyl, 3,6-diazabicyclo[3.2.0]heptanyl, 2,5-diazabicyclo[2.2.2]octanyl, 1,4-diazabicyclo[3.2.1]octanyl, 3,8-diazabicyclo[3.2.1]octanyl, 1,4-diazabicyclo[3.2.2]nonanyl, 4,7-diazaspiro[2.5]octanyl, 2,6-diazaspiro[3.3]heptanyl, 1,6-diazaspiro[3.4]octanyl, 2,6-diazaspiro[3.4]octanyl, 1,7-diazaspiro[4.4]nonanyl, 1,7-diazaspiro[3.5]nonanyl, 2,6-diazaspiro[3.5]nonanyl, 2,7-diazaspiro[3.5]nonanyl, 5,8-diazaspiro[3.5]nonanyl, 2-oxa-5,8-diazaspiro[3.5]nonanyl, 2,7-diazaspiro[4.4]nonanyl, 2,7-diazaspiro[4.5]decanyl, 2,8-diazaspiro[4.5]decanyl, 6,9-diazaspiro[4.5]decyl, 6-oxa-2,9-diazaspiro[4.5]decanyl, 2,9-diazaspiro[5.5]undecanyl, 4-azadispiro[2.1.2. 5 .3 3 ]decanyl, and 7-azadispiro[5.1.5 8 .3 6 ]hexadecanyl, where available valences permit, and three R b This includes compounds of formula (I), formula (II), or formula (III) which are substituted with a substituent.

[0032] Another embodiment is where B is azetidinyl, tetrahydrofuranyl, pyrrolidinyl, piperidinyl, piperidin-1-olate-yl, piperazinyl, 1,4-diazepanyl, 1,2-dihydropyridinyl, 1,2,5,6-tetrahydropyridinyl, 1,2,3,6-tetrahydropyridinyl, hexahydrocyclopentapyrrol-(1H)-yl, hexahydropyrrolo[3,2-b]pyrrol-(2H)-yl, hexahydropyrrolo[3,4-b]pyrrol-(2H)-yl, octahydro-2H-pyrrolo[3,4-c]pyridinyl, octahydro-5H- Pyrrolo[3,2-c]pyridinyl, octahydro-6H-pyrrolo[3,4-b]pyridinyl, hexahydropyrrolo[1,2-a]pyrazin-(2H)-one, hexahydropyrrolo[1,2-a]pyrazin-(1H)-yl, hexahydro-1H-cyclobuta[1.2-c:1,4-c′]dipyrrol-(3H)-yl, octahydropyrrolo[1,2-a]pyrazin-(1H)-yl, octahydro-2H-pyrido[1,2-a]pyrazinyl, hexahydropyrrolo[3,4-b][1,4]oxazin-(2H)-yl, 5-azaspiro[2.4]hepta nyl, 1-azaspiro[3.3]heptanyl, 4-azaspiro[2.5]octanyl, 2-oxa-6-azaspiro[3.4]octanyl, 3-azabicyclo[3.1.0]hexanyl, 8-azabicyclo[3.2.1]octanyl, 8-azabicyclo[3.2.1]oct-2-en-yl, 9-azabicyclo[3.3.1]nonanyl, 2,5-diazabicyclo[2.2.1]heptanyl, 1,4-diazabicyclo[3.1.1]heptanyl, 3,6-diazabicyclo[3.2.0]heptanyl, 2,5-diazabicyclo[2.2.2]octanyl, 1,4-diazabicyclo[3.2.1]octanyl, 3,8-diazabicyclo[3.2.1]octanyl, 1,4-diazabicyclo[3.2.2]nonanyl, 4,7-diazaspiro[2.5]octanyl, 2,6-diazaspiro[3.3]heptanyl, 1,6-diazaspiro[3.4]octanyl, 2,6-diazaspiro[3.4]octanyl, 1,7-diazaspiro[4.4]nonanyl, 1,7-diazaspiro[3.5]nonanyl, 2,6-diazaspiro[3.5]nonanyl, 2,7-diazaspiro[3.5]nonanyl, 5,8-diazaspiro[3.5]nonanyl, 2-oxa-5,8-diazaspiro[3.5]nonanyl, 2,7-diazaspiro[4.4]nonanyl, 2,7-diazaspiro[4.5]decanyl, 2,8-diazaspiro[4.5]decanyl, 6,9-diazaspiro[4.5]decyl, 6-oxa-2,9-diazaspiro[4.5]decanyl, 2,9-diazaspiro[5.5]undecanyl, 4-azadispiro[2.1.2. 5 .3 3 ]decanyl, and 7-azadispiro[5.1.5 8 .3 6 ]hexadecanyl, where available valences permit, four R b This includes compounds of formula (I), formula (II), or formula (III) which are substituted with a substituent.

[0033] Another embodiment is where B is azetidinyl, tetrahydrofuranyl, pyrrolidinyl, piperidinyl, piperidin-1-olate-yl, piperazinyl, 1,4-diazepanyl, 1,2-dihydropyridinyl, 1,2,5,6-tetrahydropyridinyl, 1,2,3,6-tetrahydropyridinyl, hexahydrocyclopentapyrrol-(1H)-yl, hexahydropyrrolo[3,2-b]pyrrol-(2H)-yl, hexahydropyrrolo[3,4-b]pyrrol-(2H)-yl, octahydro-2H-pyrrolo[3,4-c]pyridinyl, octahydro-5H- Pyrrolo[3,2-c]pyridinyl, octahydro-6H-pyrrolo[3,4-b]pyridinyl, hexahydropyrrolo[1,2-a]pyrazin-(2H)-one, hexahydropyrrolo[1,2-a]pyrazin-(1H)-yl, hexahydro-1H-cyclobuta[1.2-c:1,4-c′]dipyrrol-(3H)-yl, octahydropyrrolo[1,2-a]pyrazin-(1H)-yl, octahydro-2H-pyrido[1,2-a]pyrazinyl, hexahydropyrrolo[3,4-b][1,4]oxazin-(2H)-yl, 5-azaspiro[2.4]hepta nyl, 1-azaspiro[3.3]heptanyl, 4-azaspiro[2.5]octanyl, 2-oxa-6-azaspiro[3.4]octanyl, 3-azabicyclo[3.1.0]hexanyl, 8-azabicyclo[3.2.1]octanyl, 8-azabicyclo[3.2.1]oct-2-en-yl, 9-azabicyclo[3.3.1]nonanyl, 2,5-diazabicyclo[2.2.1]heptanyl, 1,4-diazabicyclo[3.1.1]heptanyl, 3,6-diazabicyclo[3.2.0]heptanyl, 2,5-diazabicyclo[2.2.2]octanyl, 1,4-diazabicyclo[3.2.1]octanyl, 3,8-diazabicyclo[3.2.1]octanyl, 1,4-diazabicyclo[3.2.2]nonanyl, 4,7-diazaspiro[2.5]octanyl, 2,6-diazaspiro[3.3]heptanyl, 1,6-diazaspiro[3.4]octanyl, 2,6-diazaspiro[3.4]octanyl, 1,7-diazaspiro[4.4]nonanyl, 1,7-diazaspiro[3.5]nonanyl, 2,6-diazaspiro[3.5]nonanyl, 2,7-diazaspiro[3.5]nonanyl, 5,8-diazaspiro[3.5]nonanyl, 2-oxa-5,8-diazaspiro[3.5]nonanyl, 2,7-diazaspiro[4.4]nonanyl, 2,7-diazaspiro[4.5]decanyl, 2,8-diazaspiro[4.5]decanyl, 6,9-diazaspiro[4.5]decyl, 6-oxa-2,9-diazaspiro[4.5]decanyl, 2,9-diazaspiro[5.5]undecanyl, 4-azadispiro[2.1.2. 5 .3 3 ]decanyl, and 7-azadispiro[5.1.5 8 .3 6 ]hexadecanyl, where available valences permit, five R b This includes compounds of formula (I), formula (II), or formula (III) which are substituted with a substituent.

[0034] Another embodiment is where B is selected from the group consisting of pyrrolidinyl, piperidinyl, piperidin-1-olate-yl, piperazinyl, 4-azaspiro[2.5]octanyl, 8-azabicyclo[3.2.1]octanyl, 2,5-diazabicyclo[2.2.1]heptanyl, 1,6-diazaspiro[3.4]octanyl, 2-oxa-5,8-diazaspiro[3.5]nonanyl, and 4-azadispiro[2.1.2]octanyl. 5 .3 3 ]decanyl, where available valences permit, 1, 2, 3, 4 or 5 R b This includes compounds of formula (I), formula (II), or formula (III) which may be substituted with a substituent.

[0035] Another embodiment is where B is selected from the group consisting of pyrrolidinyl, piperidinyl, piperidin-1-olate-yl, piperazinyl, 4-azaspiro[2.5]octanyl, 8-azabicyclo[3.2.1]octanyl, 2,5-diazabicyclo[2.2.1]heptanyl, 1,6-diazaspiro[3.4]octanyl, 2-oxa-5,8-diazaspiro[3.5]nonanyl, and 4-azadispiro[2.1.2]octanyl. 5 .3 3 ]decanyl.

[0036] Another embodiment is where B is selected from the group consisting of pyrrolidinyl, piperidinyl, piperidin-1-olate-yl, piperazinyl, 4-azaspiro[2.5]octanyl, 8-azabicyclo[3.2.1]octanyl, 2,5-diazabicyclo[2.2.1]heptanyl, 1,6-diazaspiro[3.4]octanyl, 2-oxa-5,8-diazaspiro[3.5]nonanyl, and 4-azadispiro[2.1.2]octanyl. 5 .3 3 ]decanyl, where available valences permit, one R b This includes compounds of formula (I), formula (II), or formula (III) which are substituted with a substituent.

[0037] Another embodiment is where B is selected from the group consisting of pyrrolidinyl, piperidinyl, piperidin-1-olate-yl, piperazinyl, 4-azaspiro[2.5]octanyl, 8-azabicyclo[3.2.1]octanyl, 2,5-diazabicyclo[2.2.1]heptanyl, 1,6-diazaspiro[3.4]octanyl, 2-oxa-5,8-diazaspiro[3.5]nonanyl, and 4-azadispiro[2.1.2]octanyl. 5 .3 3 ]decanyl, where available valences permit, two R b This includes compounds of formula (I), formula (II), or formula (III) which are substituted with a substituent.

[0038] Another embodiment is where B is selected from the group consisting of pyrrolidinyl, piperidinyl, piperidin-1-olate-yl, piperazinyl, 4-azaspiro[2.5]octanyl, 8-azabicyclo[3.2.1]octanyl, 2,5-diazabicyclo[2.2.1]heptanyl, 1,6-diazaspiro[3.4]octanyl, 2-oxa-5,8-diazaspiro[3.5]nonanyl, and 4-azadispiro[2.1.2]octanyl. 5 .3 3 ]decanyl, where available valences permit, three R bThis includes compounds of formula (I), formula (II), or formula (III) which are substituted with a substituent.

[0039] Another embodiment is where B is heterocyclyl selected from pyrrolidinyl, piperidinyl, piperazinyl, and 4-azaspiro[2.5]octanyl, and where available valences permit, 1, 2, 3, 4, or 5 R b This includes compounds of formula (I), formula (II), or formula (III) which may be substituted with a substituent.

[0040] Another embodiment includes compounds of formula (I), formula (II), or formula (III) where B is unsubstituted heterocyclyl selected from pyrrolidinyl, piperidinyl, piperazinyl, and 4-azaspiro[2.5]octanyl.

[0041] Another embodiment is where B is heterocyclyl selected from pyrrolidinyl, piperidinyl, piperazinyl, and 4-azaspiro[2.5]octanyl, and where available valences permit, one R b This includes compounds of formula (I), formula (II), or formula (III) which are substituted with a substituent.

[0042] Another embodiment is where B is heterocyclyl selected from pyrrolidinyl, piperidinyl, piperazinyl, and 4-azaspiro[2.5]octanyl, and where available valences permit, two R b This includes compounds of formula (I), formula (II), or formula (III) which are substituted with a substituent.

[0043] Another embodiment is where B is heterocyclyl selected from pyrrolidinyl, piperidinyl, piperazinyl, and 4-azaspiro[2.5]octanyl, and where available valences permit, three R b This includes compounds of formula (I), formula (II), or formula (III) which are substituted with a substituent.

[0044] Another embodiment is where B is heterocyclyl selected from pyrrolidinyl, piperidinyl, piperazinyl, and 4-azaspiro[2.5]octanyl, and where available valences permit, four R b This includes compounds of formula (I), formula (II), or formula (III) which are substituted with a substituent.

[0045] Another embodiment is where B is heterocyclyl selected from pyrrolidinyl, piperidinyl, piperazinyl, and 4-azaspiro[2.5]octanyl, and where available valences permit, five R b This includes compounds of formula (I), formula (II), or formula (III) which are substituted with a substituent.

[0046] Another embodiment is where B is pyrrolidinyl and, where available valences permit, one R b This includes compounds of formula (I), formula (II), or formula (III) which are substituted with a substituent.

[0047] Another embodiment is where B is piperidinyl and, where available valences allow, four R b This includes compounds of formula (I), formula (II), or formula (III) which are substituted with a substituent.

[0048] Another embodiment is where B is piperidinyl and, where available valences permit, five R b This includes compounds of formula (I), formula (II), or formula (III) which are substituted with a substituent.

[0049] Another embodiment includes compounds of formula (I), formula (II), or formula (III) where B is unsubstituted piperazinyl.

[0050] Another embodiment is where B is piperazinyl and, where available valences permit, one R b This includes compounds of formula (I), formula (II), or formula (III) which are substituted with a substituent.

[0051] Another embodiment is where B is piperazinyl and where available valences allow, two R b This includes compounds of formula (I), formula (II), or formula (III) which are substituted with a substituent.

[0052] Another embodiment is where B is piperazinyl and, where available valences allow, three R b This includes compounds of formula (I), formula (II), or formula (III) which are substituted with a substituent.

[0053] Another embodiment is where B is piperazinyl and, where available valences allow, four R b This includes compounds of formula (I), formula (II), or formula (III) which are substituted with a substituent.

[0054] Another embodiment includes compounds of Formula (I), Formula (II), or Formula (III) where B is unsubstituted 4-azaspiro[2.5]octanyl.

[0055] Another embodiment is where B is 4-azaspiro[2.5]octanyl and, where available valences permit, one R b This includes compounds of formula (I), formula (II), or formula (III) which are substituted with a substituent.

[0056] Another embodiment is where B is 4-azaspiro[2.5]octanyl and, where available valences permit, two R b This includes compounds of formula (I), formula (II), or formula (III) which are substituted with a substituent.

[0057] Another embodiment is where B is azetidin-1-yl, tetrahydrofuran-3-yl, pyrrolidin-1-yl, pyrrolidin-3-yl, piperidin-1-yl, piperidin-3-yl, piperidin-4-yl, piperidin-1-olate-4-yl, piperazin-1-yl, 1,4-diazepin-1-yl, 1,2-dihydropyridin-2-yl, 1,2-dihydropyridin-3-yl, 1,2-dihydropyridin-4-yl, 1,2-dihydropyridin-5-yl, 1,2-dihydropyridin-6-yl, 1,2,5,6-tetrahydropyridine-5-yl, 1,2,5,6-tetrahydropyridine ... -yl, 1,2,3,6-tetrahydropyridin-4-yl, hexahydrocyclopentapyrrol-2(1H)-yl, hexahydropyrrolo[3,2-b]pyrrol-1(2H)-yl, hexahydropyrrolo[3,4-b]pyrrol-1(2H)-yl, hexahydropyrrolo[3,4-c]pyrrol-1(1H)-yl, hexahydropyrrolo[3,4-c]pyrrol-2(1H)-yl, hexahydropyrrolo[3,4-c]pyrrol-5(1H)-yl, octahydro-5H-pyrrolo[3,2-c]pyridin-5-yl, octahydro-6H- Pyrrolo[3,4-b]pyridin-6-yl, hexahydropyrrolo[1,2-a]pyrazin-6(2H)-one, hexahydropyrrolo[1,2-a]pyrazin-2(1H)-yl, hexahydro-1H-cyclobuta[1.2-c:1,4-c′]dipyrrol-2(3H)-yl, octahydropyrrolo[1,2-a]pyrazin-2(1H)-yl, octahydro-2H-pyrido[1,2-a]pyrazin-2-yl, hexahydropyrrolo[3,4-b][1,4]oxazin-6(2H)-yl, 5-azaspiro[2.4]heptan-5-yl, 1- Azaspiro[3.3]heptan-2-yl, 4-azaspiro[2.5]octan-7-yl, 2-oxa-6-azaspiro[3.4]octan-6-yl, 3-azabicyclo[3.1.0]hexan-3-yl, 8-azabicyclo[3.2.1]octan-3-yl, 8-azabicyclo[3.2.1]oct-2-en-3-yl, 9-azabicyclo[3.3.1]nonan-3-yl, 2,5-diazabicyclo[2.2.1]heptan-2-yl, 1,4-diazabicyclo[3.1.1]heptan-4-yl, 3,6-diazabicyclo[3.2.0]heptan-3-yl, 3,6-diazabicyclo[3.2.0]heptan-6-yl, 2,5-diazabicyclo[2.2.2]octan-2-yl, 1,4-diazabicyclo[3.2.1]octan-4-yl, 3,8-diazabicyclo[3.2.1]octan-3-yl, 1,4-diazabicyclo[3.2.2]nonan-4-yl, 4,7-diazaspiro[2.5]octan-4-yl, 4,7-diazaspiro [2.5]octan-7-yl, 2,6-diazaspiro[3.3]heptan-2-yl, 1,6-diazaspiro[3.4]octan-6-yl, 2,6-diazaspiro[3.4]octan-2-yl, 2,6-diazaspiro[3.4]octan-6-yl, 1,7-diazaspiro[4.4]nonan-1-yl, 1,7-diazaspiro[4.4]nonan-7-yl, 1,7-diazaspiro[3.5]nonan-7-yl yl, 2,6-diazaspiro[3.5]nonan-2-yl, 2,6-diazaspiro[3.5]nonan-6-yl, 1,7-diazaspiro[3.5]nonan-7-yl, 2,7-diazaspiro[3.5]nonan-2-yl, 2,7-diazaspiro[3.5]nonan-7-yl, 5,8-diazaspiro[3.5]nonan-8-yl, 2-oxa-5,8-diazaspiro[3.5]nonan-8-yl, 2,7-diazaspiro[3.5]nonan-8-yl ro[4.4]nonan-2-yl, 2,7-diazaspiro[4.5]decan-2-yl, 2,7-diazaspiro[4.5]decan-7-yl, 2,8-diazaspiro[4.5]decan-8-yl, 6,9-diazaspiro[4.5]decane(dec)-9-yl, 6-oxa-2,9-diazaspiro[4.5]decan-2-yl, 2,9-diazaspiro[5.5]undecane-9-yl, 4-azadispiro[2.1.2. 5 .3 3 ]decan-9-yl, and 7-azadispiro[5.1.5 8 .3 6 ]hexadecan-15-yl, where available valences permit, one, two, three, four or five R b This includes compounds of formula (I), formula (II), or formula (III) which may be substituted with a substituent.

[0058] Another embodiment is where B is azetidin-1-yl, tetrahydrofuran-3-yl, pyrrolidin-1-yl, pyrrolidin-3-yl, piperidin-1-yl, piperidin-3-yl, piperidin-4-yl, piperidin-1-olate-4-yl, piperazin-1-yl, 1,4-diazepin-1-yl, 1,2-dihydropyridin-2-yl, 1,2-dihydropyridin-3-yl, 1,2-dihydropyridin-4-yl, 1,2-dihydropyridin-5-yl, 1,2-dihydropyridin-6-yl, 1,2,5,6-tetrahydropyridine-5-yl, 1,2,5,6-tetrahydropyridine ... -yl, 1,2,3,6-tetrahydropyridin-4-yl, hexahydrocyclopentapyrrol-2(1H)-yl, hexahydropyrrolo[3,2-b]pyrrol-1(2H)-yl, hexahydropyrrolo[3,4-b]pyrrol-1(2H)-yl, hexahydropyrrolo[3,4-c]pyrrol-1(1H)-yl, hexahydropyrrolo[3,4-c]pyrrol-2(1H)-yl, hexahydropyrrolo[3,4-c]pyrrol-5(1H)-yl, octahydro-5H-pyrrolo[3,2-c]pyridin-5-yl, octahydro-6H- Pyrrolo[3,4-b]pyridin-6-yl, hexahydropyrrolo[1,2-a]pyrazin-6(2H)-one, hexahydropyrrolo[1,2-a]pyrazin-2(1H)-yl, hexahydro-1H-cyclobuta[1.2-c:1,4-c′]dipyrrol-2(3H)-yl, octahydropyrrolo[1,2-a]pyrazin-2(1H)-yl, octahydro-2H-pyrido[1,2-a]pyrazin-2-yl, hexahydropyrrolo[3,4-b][1,4]oxazin-6(2H)-yl, 5-azaspiro[2.4]heptan-5-yl, 1- Azaspiro[3.3]heptan-2-yl, 4-azaspiro[2.5]octan-7-yl, 2-oxa-6-azaspiro[3.4]octan-6-yl, 3-azabicyclo[3.1.0]hexan-3-yl, 8-azabicyclo[3.2.1]octan-3-yl, 8-azabicyclo[3.2.1]oct-2-en-3-yl, 9-azabicyclo[3.3.1]nonan-3-yl, 2,5-diazabicyclo[2.2.1]heptan-2-yl, 1,4-diazabicyclo[3.1.1]heptan-4-yl, 3,6-diazabicyclo[3.2.0]heptan-3-yl, 3,6-diazabicyclo[3.2.0]heptan-6-yl, 2,5-diazabicyclo[2.2.2]octan-2-yl, 1,4-diazabicyclo[3.2.1]octan-4-yl, 3,8-diazabicyclo[3.2.1]octan-3-yl, 1,4-diazabicyclo[3.2.2]nonan-4-yl, 4,7-diazaspiro[2.5]octan-4-yl, 4,7-diazaspiro[2.5]octan-4-yl, 2,6-diazaspiro[3.3]heptan-2-yl, 1,6-diazaspiro[3.4]octan-6-yl, 2,6-diazaspiro[3.4]octan-2-yl, 2,6-diazaspiro[3.4]octan-6-yl, 1,7-diazaspiro[4.4]nonan-1-yl, 1,7-diazaspiro[4.4]nonan-7-yl, 1,7-diazaspiro[3.5]nonane- 7-yl, 2,6-diazaspiro[3.5]nonan-2-yl, 2,6-diazaspiro[3.5]nonan-6-yl, 1,7-diazaspiro[3.5]nonan-7-yl, 2,7-diazaspiro[3.5]nonan-2-yl, 2,7-diazaspiro[3.5]nonan-7-yl, 5,8-diazaspiro[3.5]nonan-8-yl, 2-oxa-5,8-diazaspiro[3.5]nonan-8-yl, 2,7-diaza Zaspiro[4.4]nonan-2-yl, 2,7-diazaspiro[4.5]decan-2-yl, 2,7-diazaspiro[4.5]decan-7-yl, 2,8-diazaspiro[4.5]decan-8-yl, 6,9-diazaspiro[4.5]decan-9-yl, 6-oxa-2,9-diazaspiro[4.5]decan-2-yl, 2,9-diazaspiro[5.5]undecan-9-yl, 4-azadispiro[2.1.2]undecan-2. 5 .3 3 ]decan-9-yl, and 7-azadispiro[5.1.5 8 .3 6 ]hexadecan-15-yl.

[0059] Another embodiment is where B is azetidin-1-yl, tetrahydrofuran-3-yl, pyrrolidin-1-yl, pyrrolidin-3-yl, piperidin-1-yl, piperidin-3-yl, piperidin-4-yl, piperidin-1-olate-4-yl, piperazin-1-yl, 1,4-diazepin-1-yl, 1,2-dihydropyridin-2-yl, 1,2-dihydropyridin-3-yl, 1,2-dihydropyridin-4-yl, 1,2-dihydropyridin-5-yl, 1,2-dihydropyridin-6-yl, 1,2,5,6-tetrahydropyridine-5-yl, 1,2,5,6-tetrahydropyridine ... -yl, 1,2,3,6-tetrahydropyridin-4-yl, hexahydrocyclopentapyrrol-2(1H)-yl, hexahydropyrrolo[3,2-b]pyrrol-1(2H)-yl, hexahydropyrrolo[3,4-b]pyrrol-1(2H)-yl, hexahydropyrrolo[3,4-c]pyrrol-1(1H)-yl, hexahydropyrrolo[3,4-c]pyrrol-2(1H)-yl, hexahydropyrrolo[3,4-c]pyrrol-5(1H)-yl, octahydro-5H-pyrrolo[3,2-c]pyridin-5-yl, octahydro-6H- Pyrrolo[3,4-b]pyridin-6-yl, hexahydropyrrolo[1,2-a]pyrazin-6(2H)-one, hexahydropyrrolo[1,2-a]pyrazin-2(1H)-yl, hexahydro-1H-cyclobuta[1.2-c:1,4-c′]dipyrrol-2(3H)-yl, octahydropyrrolo[1,2-a]pyrazin-2(1H)-yl, octahydro-2H-pyrido[1,2-a]pyrazin-2-yl, hexahydropyrrolo[3,4-b][1,4]oxazin-6(2H)-yl, 5-azaspiro[2.4]heptan-5-yl, 1- Azaspiro[3.3]heptan-2-yl, 4-azaspiro[2.5]octan-7-yl, 2-oxa-6-azaspiro[3.4]octan-6-yl, 3-azabicyclo[3.1.0]hexan-3-yl, 8-azabicyclo[3.2.1]octan-3-yl, 8-azabicyclo[3.2.1]oct-2-en-3-yl, 9-azabicyclo[3.3.1]nonan-3-yl, 2,5-diazabicyclo[2.2.1]heptan-2-yl, 1,4-diazabicyclo[3.1.1]heptan-4-yl, 3,6-diazabicyclo[3.2.0]heptan-3-yl, 3,6-diazabicyclo[3.2.0]heptan-6-yl, 2,5-diazabicyclo[2.2.2]octan-2-yl, 1,4-diazabicyclo[3.2.1]octan-4-yl, 3,8-diazabicyclo[3.2.1]octan-3-yl, 1,4-diazabicyclo[3.2.2]nonan-4-yl, 4,7-diazaspiro[2.5]octan-4-yl, 4,7-diazaspiro[2.5]octan-4-yl, 2,6-diazaspiro[3.3]heptan-2-yl, 1,6-diazaspiro[3.4]octan-6-yl, 2,6-diazaspiro[3.4]octan-2-yl, 2,6-diazaspiro[3.4]octan-6-yl, 1,7-diazaspiro[4.4]nonan-1-yl, 1,7-diazaspiro[4.4]nonan-7-yl, 1,7-diazaspiro[3.5]nonane- 7-yl, 2,6-diazaspiro[3.5]nonan-2-yl, 2,6-diazaspiro[3.5]nonan-6-yl, 1,7-diazaspiro[3.5]nonan-7-yl, 2,7-diazaspiro[3.5]nonan-2-yl, 2,7-diazaspiro[3.5]nonan-7-yl, 5,8-diazaspiro[3.5]nonan-8-yl, 2-oxa-5,8-diazaspiro[3.5]nonan-8-yl, 2,7-diaza Zaspiro[4.4]nonan-2-yl, 2,7-diazaspiro[4.5]decan-2-yl, 2,7-diazaspiro[4.5]decan-7-yl, 2,8-diazaspiro[4.5]decan-8-yl, 6,9-diazaspiro[4.5]decan-9-yl, 6-oxa-2,9-diazaspiro[4.5]decan-2-yl, 2,9-diazaspiro[5.5]undecan-9-yl, 4-azadispiro[2.1.2]undecan-2. 5 .3 3 ]decan-9-yl, and 7-azadispiro[5.1.5 8 .3 6 ]hexadecan-15-yl, and, if permitted by available valences, one R b This includes compounds of formula (I), formula (II), or formula (III) which are substituted with a substituent.

[0060] Another embodiment is where B is azetidin-1-yl, tetrahydrofuran-3-yl, pyrrolidin-1-yl, pyrrolidin-3-yl, piperidin-1-yl, piperidin-3-yl, piperidin-4-yl, piperidin-1-olate-4-yl, piperazin-1-yl, 1,4-diazepin-1-yl, 1,2-dihydropyridin-2-yl, 1,2-dihydropyridin-3-yl, 1,2-dihydropyridin-4-yl, 1,2-dihydropyridin-5-yl, 1,2-dihydropyridin-6-yl, 1,2,5,6-tetrahydropyridine-5-yl, 1,2,5,6-tetrahydropyridine ... -yl, 1,2,3,6-tetrahydropyridin-4-yl, hexahydrocyclopentapyrrol-2(1H)-yl, hexahydropyrrolo[3,2-b]pyrrol-1(2H)-yl, hexahydropyrrolo[3,4-b]pyrrol-1(2H)-yl, hexahydropyrrolo[3,4-c]pyrrol-1(1H)-yl, hexahydropyrrolo[3,4-c]pyrrol-2(1H)-yl, hexahydropyrrolo[3,4-c]pyrrol-5(1H)-yl, octahydro-5H-pyrrolo[3,2-c]pyridin-5-yl, octahydro-6H- Pyrrolo[3,4-b]pyridin-6-yl, hexahydropyrrolo[1,2-a]pyrazin-6(2H)-one, hexahydropyrrolo[1,2-a]pyrazin-2(1H)-yl, hexahydro-1H-cyclobuta[1.2-c:1,4-c′]dipyrrol-2(3H)-yl, octahydropyrrolo[1,2-a]pyrazin-2(1H)-yl, octahydro-2H-pyrido[1,2-a]pyrazin-2-yl, hexahydropyrrolo[3,4-b][1,4]oxazin-6(2H)-yl, 5-azaspiro[2.4]heptan-5-yl, 1- Azaspiro[3.3]heptan-2-yl, 4-azaspiro[2.5]octan-7-yl, 2-oxa-6-azaspiro[3.4]octan-6-yl, 3-azabicyclo[3.1.0]hexan-3-yl, 8-azabicyclo[3.2.1]octan-3-yl, 8-azabicyclo[3.2.1]oct-2-en-3-yl, 9-azabicyclo[3.3.1]nonan-3-yl, 2,5-diazabicyclo[2.2.1]heptan-2-yl, 1,4-diazabicyclo[3.1.1]heptan-4-yl, 3,6-diazabicyclo[3.2.0]heptan-3-yl, 3,6-diazabicyclo[3.2.0]heptan-6-yl, 2,5-diazabicyclo[2.2.2]octan-2-yl, 1,4-diazabicyclo[3.2.1]octan-4-yl, 3,8-diazabicyclo[3.2.1]octan-3-yl, 1,4-diazabicyclo[3.2.2]nonan-4-yl, 4,7-diazaspiro[2.5]octan-4-yl, 4,7-diazaspiro[2.5]octan-4-yl, 2,6-diazaspiro[3.3]heptan-2-yl, 1,6-diazaspiro[3.4]octan-6-yl, 2,6-diazaspiro[3.4]octan-2-yl, 2,6-diazaspiro[3.4]octan-6-yl, 1,7-diazaspiro[4.4]nonan-1-yl, 1,7-diazaspiro[4.4]nonan-7-yl, 1,7-diazaspiro[3.5]nonane- 7-yl, 2,6-diazaspiro[3.5]nonan-2-yl, 2,6-diazaspiro[3.5]nonan-6-yl, 1,7-diazaspiro[3.5]nonan-7-yl, 2,7-diazaspiro[3.5]nonan-2-yl, 2,7-diazaspiro[3.5]nonan-7-yl, 5,8-diazaspiro[3.5]nonan-8-yl, 2-oxa-5,8-diazaspiro[3.5]nonan-8-yl, 2,7-diaza Zaspiro[4.4]nonan-2-yl, 2,7-diazaspiro[4.5]decan-2-yl, 2,7-diazaspiro[4.5]decan-7-yl, 2,8-diazaspiro[4.5]decan-8-yl, 6,9-diazaspiro[4.5]decan-9-yl, 6-oxa-2,9-diazaspiro[4.5]decan-2-yl, 2,9-diazaspiro[5.5]undecan-9-yl, 4-azadispiro[2.1.2]undecan-2. 5 .3 3 ]decan-9-yl, and 7-azadispiro[5.1.5 8 .3 6 ]hexadecan-15-yl, and where available valences permit, two R b This includes compounds of formula (I), formula (II), or formula (III) which are substituted with a substituent.

[0061] Another embodiment is where B is azetidin-1-yl, tetrahydrofuran-3-yl, pyrrolidin-1-yl, pyrrolidin-3-yl, piperidin-1-yl, piperidin-3-yl, piperidin-4-yl, piperidin-1-olate-4-yl, piperazin-1-yl, 1,4-diazepin-1-yl, 1,2-dihydropyridin-2-yl, 1,2-dihydropyridin-3-yl, 1,2-dihydropyridin-4-yl, 1,2-dihydropyridin-5-yl, 1,2-dihydropyridin-6-yl, 1,2,5,6-tetrahydropyridine-5-yl, 1,2,5,6-tetrahydropyridine ... -yl, 1,2,3,6-tetrahydropyridin-4-yl, hexahydrocyclopentapyrrol-2(1H)-yl, hexahydropyrrolo[3,2-b]pyrrol-1(2H)-yl, hexahydropyrrolo[3,4-b]pyrrol-1(2H)-yl, hexahydropyrrolo[3,4-c]pyrrol-1(1H)-yl, hexahydropyrrolo[3,4-c]pyrrol-2(1H)-yl, hexahydropyrrolo[3,4-c]pyrrol-5(1H)-yl, octahydro-5H-pyrrolo[3,2-c]pyridin-5-yl, octahydro-6H- Pyrrolo[3,4-b]pyridin-6-yl, hexahydropyrrolo[1,2-a]pyrazin-6(2H)-one, hexahydropyrrolo[1,2-a]pyrazin-2(1H)-yl, hexahydro-1H-cyclobuta[1.2-c:1,4-c′]dipyrrol-2(3H)-yl, octahydropyrrolo[1,2-a]pyrazin-2(1H)-yl, octahydro-2H-pyrido[1,2-a]pyrazin-2-yl, hexahydropyrrolo[3,4-b][1,4]oxazin-6(2H)-yl, 5-azaspiro[2.4]heptan-5-yl, 1- Azaspiro[3.3]heptan-2-yl, 4-azaspiro[2.5]octan-7-yl, 2-oxa-6-azaspiro[3.4]octan-6-yl, 3-azabicyclo[3.1.0]hexan-3-yl, 8-azabicyclo[3.2.1]octan-3-yl, 8-azabicyclo[3.2.1]oct-2-en-3-yl, 9-azabicyclo[3.3.1]nonan-3-yl, 2,5-diazabicyclo[2.2.1]heptan-2-yl, 1,4-diazabicyclo[3.1.1]heptan-4-yl, 3,6-diazabicyclo[3.2.0]heptan-3-yl, 3,6-diazabicyclo[3.2.0]heptan-6-yl, 2,5-diazabicyclo[2.2.2]octan-2-yl, 1,4-diazabicyclo[3.2.1]octan-4-yl, 3,8-diazabicyclo[3.2.1]octan-3-yl, 1,4-diazabicyclo[3.2.2]nonan-4-yl, 4,7-diazaspiro[2.5]octan-4-yl, 4,7-diazaspiro[2.5]octan-4-yl, 2,6-diazaspiro[3.3]heptan-2-yl, 1,6-diazaspiro[3.4]octan-6-yl, 2,6-diazaspiro[3.4]octan-2-yl, 2,6-diazaspiro[3.4]octan-6-yl, 1,7-diazaspiro[4.4]nonan-1-yl, 1,7-diazaspiro[4.4]nonan-7-yl, 1,7-diazaspiro[3.5]nonane- 7-yl, 2,6-diazaspiro[3.5]nonan-2-yl, 2,6-diazaspiro[3.5]nonan-6-yl, 1,7-diazaspiro[3.5]nonan-7-yl, 2,7-diazaspiro[3.5]nonan-2-yl, 2,7-diazaspiro[3.5]nonan-7-yl, 5,8-diazaspiro[3.5]nonan-8-yl, 2-oxa-5,8-diazaspiro[3.5]nonan-8-yl, 2,7-diaza Zaspiro[4.4]nonan-2-yl, 2,7-diazaspiro[4.5]decan-2-yl, 2,7-diazaspiro[4.5]decan-7-yl, 2,8-diazaspiro[4.5]decan-8-yl, 6,9-diazaspiro[4.5]decan-9-yl, 6-oxa-2,9-diazaspiro[4.5]decan-2-yl, 2,9-diazaspiro[5.5]undecan-9-yl, 4-azadispiro[2.1.2]undecan-2. 5 .3 3 ]decan-9-yl, and 7-azadispiro[5.1.5 8 .3 6 ]hexadecan-15-yl, and where available valences permit, three R b This includes compounds of formula (I), formula (II), or formula (III) which are substituted with a substituent.

[0062] Another embodiment is where B is azetidin-1-yl, tetrahydrofuran-3-yl, pyrrolidin-1-yl, pyrrolidin-3-yl, piperidin-1-yl, piperidin-3-yl, piperidin-4-yl, piperidin-1-olate-4-yl, piperazin-1-yl, 1,4-diazepin-1-yl, 1,2-dihydropyridin-2-yl, 1,2-dihydropyridin-3-yl, 1,2-dihydropyridin-4-yl, 1,2-dihydropyridin-5-yl, 1,2-dihydropyridin-6-yl, 1,2,5,6-tetrahydropyridine-5-yl, 1,2,5,6-tetrahydropyridine ... -yl, 1,2,3,6-tetrahydropyridin-4-yl, hexahydrocyclopentapyrrol-2(1H)-yl, hexahydropyrrolo[3,2-b]pyrrol-1(2H)-yl, hexahydropyrrolo[3,4-b]pyrrol-1(2H)-yl, hexahydropyrrolo[3,4-c]pyrrol-1(1H)-yl, hexahydropyrrolo[3,4-c]pyrrol-2(1H)-yl, hexahydropyrrolo[3,4-c]pyrrol-5(1H)-yl, octahydro-5H-pyrrolo[3,2-c]pyridin-5-yl, octahydro-6H- Pyrrolo[3,4-b]pyridin-6-yl, hexahydropyrrolo[1,2-a]pyrazin-6(2H)-one, hexahydropyrrolo[1,2-a]pyrazin-2(1H)-yl, hexahydro-1H-cyclobuta[1.2-c:1,4-c′]dipyrrol-2(3H)-yl, octahydropyrrolo[1,2-a]pyrazin-2(1H)-yl, octahydro-2H-pyrido[1,2-a]pyrazin-2-yl, hexahydropyrrolo[3,4-b][1,4]oxazin-6(2H)-yl, 5-azaspiro[2.4]heptan-5-yl, 1- Azaspiro[3.3]heptan-2-yl, 4-azaspiro[2.5]octan-7-yl, 2-oxa-6-azaspiro[3.4]octan-6-yl, 3-azabicyclo[3.1.0]hexan-3-yl, 8-azabicyclo[3.2.1]octan-3-yl, 8-azabicyclo[3.2.1]oct-2-en-3-yl, 9-azabicyclo[3.3.1]nonan-3-yl, 2,5-diazabicyclo[2.2.1]heptan-2-yl, 1,4-diazabicyclo[3.1.1]heptan-4-yl, 3,6-diazabicyclo[3.2.0]heptan-3-yl, 3,6-diazabicyclo[3.2.0]heptan-6-yl, 2,5-diazabicyclo[2.2.2]octan-2-yl, 1,4-diazabicyclo[3.2.1]octan-4-yl, 3,8-diazabicyclo[3.2.1]octan-3-yl, 1,4-diazabicyclo[3.2.2]nonan-4-yl, 4,7-diazaspiro[2.5]octan-4-yl, 4,7-diazaspiro[2.5]octan-4-yl, 2,6-diazaspiro[3.3]heptan-2-yl, 1,6-diazaspiro[3.4]octan-6-yl, 2,6-diazaspiro[3.4]octan-2-yl, 2,6-diazaspiro[3.4]octan-6-yl, 1,7-diazaspiro[4.4]nonan-1-yl, 1,7-diazaspiro[4.4]nonan-7-yl, 1,7-diazaspiro[3.5]nonane- 7-yl, 2,6-diazaspiro[3.5]nonan-2-yl, 2,6-diazaspiro[3.5]nonan-6-yl, 1,7-diazaspiro[3.5]nonan-7-yl, 2,7-diazaspiro[3.5]nonan-2-yl, 2,7-diazaspiro[3.5]nonan-7-yl, 5,8-diazaspiro[3.5]nonan-8-yl, 2-oxa-5,8-diazaspiro[3.5]nonan-8-yl, 2,7-diaza Zaspiro[4.4]nonan-2-yl, 2,7-diazaspiro[4.5]decan-2-yl, 2,7-diazaspiro[4.5]decan-7-yl, 2,8-diazaspiro[4.5]decan-8-yl, 6,9-diazaspiro[4.5]decan-9-yl, 6-oxa-2,9-diazaspiro[4.5]decan-2-yl, 2,9-diazaspiro[5.5]undecan-9-yl, 4-azadispiro[2.1.2]undecan-2. 5 .3 3 ]decan-9-yl, and 7-azadispiro[5.1.5 8 .3 6 ]hexadecan-15-yl, and, where available valences permit, four R b This includes compounds of formula (I), formula (II), or formula (III) which are substituted with a substituent.

[0063] Another embodiment is where B is azetidin-1-yl, tetrahydrofuran-3-yl, pyrrolidin-1-yl, pyrrolidin-3-yl, piperidin-1-yl, piperidin-3-yl, piperidin-4-yl, piperidin-1-olate-4-yl, piperazin-1-yl, 1,4-diazepin-1-yl, 1,2-dihydropyridin-2-yl, 1,2-dihydropyridin-3-yl, 1,2-dihydropyridin-4-yl, 1,2-dihydropyridin-5-yl, 1,2-dihydropyridin-6-yl, 1,2,5,6-tetrahydropyridine-5-yl, 1,2,5,6-tetrahydropyridine ... -yl, 1,2,3,6-tetrahydropyridin-4-yl, hexahydrocyclopentapyrrol-2(1H)-yl, hexahydropyrrolo[3,2-b]pyrrol-1(2H)-yl, hexahydropyrrolo[3,4-b]pyrrol-1(2H)-yl, hexahydropyrrolo[3,4-c]pyrrol-1(1H)-yl, hexahydropyrrolo[3,4-c]pyrrol-2(1H)-yl, hexahydropyrrolo[3,4-c]pyrrol-5(1H)-yl, octahydro-5H-pyrrolo[3,2-c]pyridin-5-yl, octahydro-6H- Pyrrolo[3,4-b]pyridin-6-yl, hexahydropyrrolo[1,2-a]pyrazin-6(2H)-one, hexahydropyrrolo[1,2-a]pyrazin-2(1H)-yl, hexahydro-1H-cyclobuta[1.2-c:1,4-c′]dipyrrol-2(3H)-yl, octahydropyrrolo[1,2-a]pyrazin-2(1H)-yl, octahydro-2H-pyrido[1,2-a]pyrazin-2-yl, hexahydropyrrolo[3,4-b][1,4]oxazin-6(2H)-yl, 5-azaspiro[2.4]heptan-5-yl, 1- Azaspiro[3.3]heptan-2-yl, 4-azaspiro[2.5]octan-7-yl, 2-oxa-6-azaspiro[3.4]octan-6-yl, 3-azabicyclo[3.1.0]hexan-3-yl, 8-azabicyclo[3.2.1]octan-3-yl, 8-azabicyclo[3.2.1]oct-2-en-3-yl, 9-azabicyclo[3.3.1]nonan-3-yl, 2,5-diazabicyclo[2.2.1]heptan-2-yl, 1,4-diazabicyclo[3.1.1]heptan-4-yl, 3,6-diazabicyclo[3.2.0]heptan-3-yl, 3,6-diazabicyclo[3.2.0]heptan-6-yl, 2,5-diazabicyclo[2.2.2]octan-2-yl, 1,4-diazabicyclo[3.2.1]octan-4-yl, 3,8-diazabicyclo[3.2.1]octan-3-yl, 1,4-diazabicyclo[3.2.2]nonan-4-yl, 4,7-diazaspiro[2.5]octan-4-yl, 4,7-diazaspiro[2.5]octan-4-yl, 2,6-diazaspiro[3.3]heptan-2-yl, 1,6-diazaspiro[3.4]octan-6-yl, 2,6-diazaspiro[3.4]octan-2-yl, 2,6-diazaspiro[3.4]octan-6-yl, 1,7-diazaspiro[4.4]nonan-1-yl, 1,7-diazaspiro[4.4]nonan-7-yl, 1,7-diazaspiro[3.5]nonane- 7-yl, 2,6-diazaspiro[3.5]nonan-2-yl, 2,6-diazaspiro[3.5]nonan-6-yl, 1,7-diazaspiro[3.5]nonan-7-yl, 2,7-diazaspiro[3.5]nonan-2-yl, 2,7-diazaspiro[3.5]nonan-7-yl, 5,8-diazaspiro[3.5]nonan-8-yl, 2-oxa-5,8-diazaspiro[3.5]nonan-8-yl, 2,7-diaza Zaspiro[4.4]nonan-2-yl, 2,7-diazaspiro[4.5]decan-2-yl, 2,7-diazaspiro[4.5]decan-7-yl, 2,8-diazaspiro[4.5]decan-8-yl, 6,9-diazaspiro[4.5]decan-9-yl, 6-oxa-2,9-diazaspiro[4.5]decan-2-yl, 2,9-diazaspiro[5.5]undecan-9-yl, 4-azadispiro[2.1.2]undecan-2. 5 .3 3 ]decan-9-yl, and 7-azadispiro[5.1.5 8 .3 6 ]hexadecan-15-yl, and where available valences permit, five R b This includes compounds of formula (I), formula (II), or formula (III) which are substituted with a substituent.

[0064] Another embodiment is where B is selected from the group consisting of pyrrolidin-1-yl, piperidin-4-yl, piperidin-1-olate-4-yl, piperazin-1-yl, 4-azaspiro[2.5]octan-7-yl, 8-azabicyclo[3.2.1]octan-3-yl, 2,5-diazabicyclo[2.2.1]heptan-2-yl, 1,6-diazaspiro[3.4]octan-6-yl, 2-oxa-5,8-diazaspiro[3.5]nonan-8-yl, and 4-azadispiro[2.1.2]octan-1-yl. 5 .3 3 ]decan-9-yl, where available valences permit, 1, 2, 3, 4 or 5 R b This includes compounds of formula (I), formula (II), or formula (III) which may be substituted with a substituent.

[0065] Another embodiment is where B is selected from the group consisting of pyrrolidin-1-yl, piperidin-4-yl, piperidin-1-olate-4-yl, piperazin-1-yl, 4-azaspiro[2.5]octan-7-yl, 8-azabicyclo[3.2.1]octan-3-yl, 2,5-diazabicyclo[2.2.1]heptan-2-yl, 1,6-diazaspiro[3.4]octan-6-yl, 2-oxa-5,8-diazaspiro[3.5]nonan-8-yl, and 4-azadispiro[2.1.2]octan-1-yl. 5 .3 3 ]decan-9-yl is an unsubstituted heterocyclyl selected from the group consisting of 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29

[0066] Another embodiment is where B is selected from the group consisting of pyrrolidin-1-yl, piperidin-4-yl, piperidin-1-olate-4-yl, piperazin-1-yl, 4-azaspiro[2.5]octan-7-yl, 8-azabicyclo[3.2.1]octan-3-yl, 2,5-diazabicyclo[2.2.1]heptan-2-yl, 1,6-diazaspiro[3.4]octan-6-yl, 2-oxa-5,8-diazaspiro[3.5]nonan-8-yl, and 4-azadispiro[2.1.2]octan-1-yl. 5 .3 3]decan-9-yl, and, if permitted by available valences, one R b This includes compounds of formula (I), formula (II), or formula (III) which are substituted with a substituent.

[0067] Another embodiment is where B is selected from the group consisting of pyrrolidin-1-yl, piperidin-4-yl, piperidin-1-olate-4-yl, piperazin-1-yl, 4-azaspiro[2.5]octan-7-yl, 8-azabicyclo[3.2.1]octan-3-yl, 2,5-diazabicyclo[2.2.1]heptan-2-yl, 1,6-diazaspiro[3.4]octan-6-yl, 2-oxa-5,8-diazaspiro[3.5]nonan-8-yl, and 4-azadispiro[2.1.2]octan-1-yl. 5 .3 3 ]decan-9-yl, and where available valences permit, two R b This includes compounds of formula (I), formula (II), or formula (III) which are substituted with a substituent.

[0068] Another embodiment is where B is selected from the group consisting of pyrrolidin-1-yl, piperidin-4-yl, piperidin-1-olate-4-yl, piperazin-1-yl, 4-azaspiro[2.5]octan-7-yl, 8-azabicyclo[3.2.1]octan-3-yl, 2,5-diazabicyclo[2.2.1]heptan-2-yl, 1,6-diazaspiro[3.4]octan-6-yl, 2-oxa-5,8-diazaspiro[3.5]nonan-8-yl, and 4-azadispiro[2.1.2]octan-1-yl. 5 .3 3 ]decan-9-yl, and where available valences permit, three R b This includes compounds of formula (I), formula (II), or formula (III) which are substituted with a substituent.

[0069] Another embodiment is where B is selected from the group consisting of pyrrolidin-1-yl, piperidin-4-yl, piperidin-1-olate-4-yl, piperazin-1-yl, 4-azaspiro[2.5]octan-7-yl, 8-azabicyclo[3.2.1]octan-3-yl, 2,5-diazabicyclo[2.2.1]heptan-2-yl, 1,6-diazaspiro[3.4]octan-6-yl, 2-oxa-5,8-diazaspiro[3.5]nonan-8-yl, and 4-azadispiro[2.1.2]octan-1-yl. 5 .3 3 ]decan-9-yl, and, where available valences permit, four R b This includes compounds of formula (I), formula (II), or formula (III) which are substituted with a substituent.

[0070] Another embodiment is where B is selected from the group consisting of pyrrolidin-1-yl, piperidin-4-yl, piperidin-1-olate-4-yl, piperazin-1-yl, 4-azaspiro[2.5]octan-7-yl, 8-azabicyclo[3.2.1]octan-3-yl, 2,5-diazabicyclo[2.2.1]heptan-2-yl, 1,6-diazaspiro[3.4]octan-6-yl, 2-oxa-5,8-diazaspiro[3.5]nonan-8-yl, and 4-azadispiro[2.1.2]octan-1-yl. 5 .3 3 ]decan-9-yl, and, where available valences permit, five R b This includes compounds of formula (I), formula (II), or formula (III) which are substituted with a substituent.

[0071] Another embodiment is where B is heterocyclyl selected from pyrrolidin-1-yl, piperidin-4-yl, piperazin-1-yl, and 4-azaspiro[2.5]octan-7-yl, where available valences permit, 1, 2, 3, 4, or 5 R b This includes compounds of formula (I), formula (II), or formula (III) which may be substituted with a substituent.

[0072] Another embodiment includes compounds of formula (I), formula (II), or formula (III) where B is an unsubstituted heterocyclyl selected from pyrrolidin-1-yl, piperidin-4-yl, piperazin-1-yl, and 4-azaspiro[2.5]octan-7-yl.

[0073] Another embodiment is where B is heterocyclyl selected from pyrrolidin-1-yl, piperidin-4-yl, piperazin-1-yl, and 4-azaspiro[2.5]octan-7-yl, where available valences permit, one R b This includes compounds of formula (I), formula (II), or formula (III) which are substituted with a substituent.

[0074] Another embodiment is where B is heterocyclyl selected from pyrrolidin-1-yl, piperidin-4-yl, piperazin-1-yl, and 4-azaspiro[2.5]octan-7-yl, and where available valences permit, two R b This includes compounds of formula (I), formula (II), or formula (III) which are substituted with a substituent.

[0075] Another embodiment is where B is heterocyclyl selected from pyrrolidin-1-yl, piperidin-4-yl, piperazin-1-yl, and 4-azaspiro[2.5]octan-7-yl, and where available valences permit, three R b This includes compounds of formula (I), formula (II), or formula (III) which are substituted with a substituent.

[0076] Another embodiment is where B is heterocyclyl selected from pyrrolidin-1-yl, piperidin-4-yl, piperazin-1-yl, and 4-azaspiro[2.5]octan-7-yl, where available valences permit, four R b This includes compounds of formula (I), formula (II), or formula (III) which are substituted with a substituent.

[0077] Another embodiment is where B is heterocyclyl selected from pyrrolidin-1-yl, piperidin-4-yl, piperazin-1-yl, and 4-azaspiro[2.5]octan-7-yl, and where available valences permit, five R b This includes compounds of formula (I), formula (II), or formula (III) which are substituted with a substituent.

[0078] Another embodiment is where B is pyrrolidin-1-yl and, where available valences permit, one R b This includes compounds of formula (I), formula (II), or formula (III) which are substituted with a substituent.

[0079] Another embodiment is where B is piperidin-4-yl and, where available valences allow, 4 or 5 R b This includes compounds of formula (I), formula (II), or formula (III) which are substituted with a substituent.

[0080] Another embodiment is where B is piperidin-4-yl and, where available valences allow, four R b This includes compounds of formula (I), formula (II), or formula (III) which are substituted with a substituent.

[0081] Another embodiment is where B is piperidin-4-yl and, where available valences allow, five R b This includes compounds of formula (I), formula (II), or formula (III) which are substituted with a substituent.

[0082] Another embodiment includes compounds of Formula (I), Formula (II), or Formula (III) where B is unsubstituted piperazin-1-yl.

[0083] Another embodiment is where B is piperazin-1-yl and, where available valences permit, one R b This includes compounds of formula (I), formula (II), or formula (III) which are substituted with a substituent.

[0084] Another embodiment is where B is piperazin-1-yl and, where available valences permit, two R b This includes compounds of formula (I), formula (II), or formula (III) which are substituted with a substituent.

[0085] Another embodiment is where B is piperazin-1-yl and, where available valences allow, three R b This includes compounds of formula (I), formula (II), or formula (III) which are substituted with a substituent.

[0086] Another embodiment is where B is piperazin-1-yl and, where available valences allow, four R b This includes compounds of formula (I), formula (II), or formula (III) which are substituted with a substituent.

[0087] Another embodiment includes compounds of formula (I), formula (II), or formula (III) where B is unsubstituted 4-azaspiro[2.5]octan-7-yl.

[0088] Another embodiment is where B is 4-azaspiro[2.5]octan-7-yl and, where available valences permit, one R b This includes compounds of formula (I), formula (II), or formula (III) which are substituted with a substituent.

[0089] Another embodiment is where B is 4-azaspiro[2.5]octan-7-yl and, where available valences permit, two R b This includes compounds of formula (I), formula (II), or formula (III) which are substituted with a substituent.

[0090] Another embodiment includes compounds of formula (I), formula (II), or formula (III) where B is heterocyclyl containing at least one asymmetric carbon atom having the (R) configuration.

[0091] Another embodiment includes compounds of formula (I), formula (II), or formula (III) where B is heterocyclyl containing at least one asymmetric carbon atom having an (S) configuration.

[0092] In one embodiment, R b But halogen, C 1-4 Alkyl, Amino, C 1-4 Alkyl-amino, (C 1-4 Alkyl) 2 -amino, and C 3-6 cycloalkyl is selected from the group consisting of cycloalkyl, ...

[0093] Another aspect is R b But halogen, C 1-4 Alkyl, C 1-4 Alkyl-amino, and C 3-6 cycloalkyl is selected from the group consisting of cycloalkyl, ...

[0094] Another aspect is R b is a halogen selected from bromo, chloro, fluoro, and iodo.

[0095] Another aspect is R b is fluoro.

[0096] Another aspect is R b is selected from methyl, ethyl, propyl, isopropyl, butyl, and tert-butyl; 1-4 This includes compounds of formula (I), formula (II), or formula (III) in which:

[0097] Another aspect is R b is selected from methyl, ethyl, and isopropyl; 1-4 This includes compounds of formula (I), formula (II), or formula (III) in which:

[0098] Another aspect is R b is methyl.

[0099] Another aspect is R b is ethyl.

[0100] Another aspect is R b is isopropyl.

[0101] Another aspect is R b C 1-4 Includes compounds of formula (I), formula (II), or formula (III) that are alkyl-amino.

[0102] Another aspect is R b But, C 1-4 Alkyl-amino, C 1-4 Includes compounds of formula (I), formula (II), or formula (III) where alkyl is selected from methyl, ethyl, propyl, isopropyl, butyl, and tert-butyl.

[0103] Another aspect is R b is selected from methylamino and tert-butylamino.

[0104] Another aspect is R b is methylamino.

[0105] Another aspect is R b is tert-butylamino.

[0106] Another aspect is R b is selected from cyclopropyl, cyclobutyl, cyclopentyl, and cyclohexyl; 3-6 Includes compounds of formula (I), formula (II), or formula (III) which are cycloalkyl.

[0107] Another aspect is R bis cyclopropyl.

[0108] In one embodiment, R 1 Heteroaryl, heterocyclyl, phenyl, heteroaryl-C 1-4 Alkyl, Heteroaryl-C 2-4 Alkenyl, Heteroaryl-amino, and Heteroaryl-C 1-4 alkyl-amino, Heteroaryl is a 3-7 membered monocyclic or 6-10 membered bicyclic ring system having 1, 2, 3, or 4 heteroatom ring members independently selected from N, O, or S; Heterocyclyl is a saturated or partially unsaturated 3- to 7-membered monocyclic, 6- to 10-membered bicyclic or 13- to 16-membered polycyclic ring system having 1, 2 or 3 heteroatom ring members independently selected from N, O or S; Each example of phenyl, heteroaryl, or heterocyclyl may have one or two R 1a It may be substituted with a substituent.

[0109] Another aspect is R 1 Heteroaryl, heterocyclyl, phenyl, heteroaryl-C 1-4 Alkyl, Heteroaryl-C 2-4 Alkenyl, Heteroaryl-amino, and Heteroaryl-C 1-4 alkyl-amino, Heteroaryl is a 3-7 membered monocyclic or 6-10 membered bicyclic ring system having 1, 2, 3, or 4 heteroatom ring members independently selected from N, O, or S; Heterocyclyl is a saturated or partially unsaturated 3- to 7-membered monocyclic, 6- to 10-membered bicyclic or 13- to 16-membered polycyclic ring system having 1, 2 or 3 heteroatom ring members independently selected from N, O or S; Each instance of phenyl, heteroaryl or heterocyclyl is unsubstituted.

[0110] Another aspect is R 1 Heteroaryl, heterocyclyl, phenyl, heteroaryl-C 1-4 Alkyl, Heteroaryl-C 2-4 Alkenyl, Heteroaryl-amino, and Heteroaryl-C 1-4 alkyl-amino, Heteroaryl is a 3-7 membered monocyclic or 6-10 membered bicyclic ring system having 1, 2, 3, or 4 heteroatom ring members independently selected from N, O, or S; Heterocyclyl is a saturated or partially unsaturated 3- to 7-membered monocyclic, 6- to 10-membered bicyclic or 13- to 16-membered polycyclic ring system having 1, 2 or 3 heteroatom ring members independently selected from N, O or S; Each example of phenyl, heteroaryl, or heterocyclyl may be substituted with one R 1a It is substituted with a substituent.

[0111] Another aspect is R 1 Heteroaryl, heterocyclyl, phenyl, heteroaryl-C 1-4 Alkyl, Heteroaryl-C 2-4 Alkenyl, Heteroaryl-amino, and Heteroaryl-C 1-4 alkyl-amino, Heteroaryl is a 3-7 membered monocyclic or 6-10 membered bicyclic ring system having 1, 2, 3, or 4 heteroatom ring members independently selected from N, O, or S; Heterocyclyl is a saturated or partially unsaturated 3- to 7-membered monocyclic, 6- to 10-membered bicyclic or 13- to 16-membered polycyclic ring system having 1, 2 or 3 heteroatom ring members independently selected from N, O or S; Each example of phenyl, heteroaryl, or heterocyclyl may have two R 1a It is substituted with a substituent.

[0112] Another aspect is R 1 Heteroaryl, Heteroaryl-C 2-4 Alkenyl, Heteroaryl-amino, and Heteroaryl-C 1-4 alkyl-amino, Heteroaryl is a 3-7 membered monocyclic or 6-10 membered bicyclic ring system having 1, 2, 3, or 4 heteroatom ring members independently selected from N, O, or S, and heteroaryl may contain, where available valences permit, one or two R 1a It may be substituted with a substituent.

[0113] Another aspect is R 1 Heteroaryl, heterocyclyl, phenyl, heteroaryl-C 1-4 Alkyl, Heteroaryl-C 2-4 Alkenyl, Heteroaryl-amino, and Heteroaryl-C 1-4 alkyl-amino, Heteroaryl is a 3-7 membered monocyclic or 6-10 membered bicyclic ring system having 1, 2, 3, or 4 heteroatom ring members independently selected from N, O, or S, and heteroaryl is unsubstituted.

[0114] Another aspect is R 1 Heteroaryl, Heteroaryl-C 2-4 Alkenyl, Heteroaryl-amino, and Heteroaryl-C 1-4 alkyl-amino, Heteroaryl is a 3-7 membered monocyclic or 6-10 membered bicyclic ring system having 1, 2, 3, or 4 heteroatom ring members independently selected from N, O, or S, and heteroaryl may contain, where available valences permit, one R 1a It is substituted with a substituent.

[0115] Another aspect is R 1 Heteroaryl, Heteroaryl-C 2-4 Alkenyl, Heteroaryl-amino, and Heteroaryl-C 1-4 alkyl-amino, Heteroaryl is a 3-7 membered monocyclic or 6-10 membered bicyclic ring system having 1, 2, 3, or 4 heteroatom ring members independently selected from N, O, or S, and heteroaryl may contain, where available valences permit, two R 1a It is substituted with a substituent.

[0116] Another aspect is R 1thienyl, 1H-pyrazolyl, 1H-imidazolyl, 1,3-thiazolyl, oxazolyl, 1,2,4-oxadiazolyl, 1,3,4-oxadiazolyl, 1,2,4-thiadiazolyl, 1H-1,2,3-triazolyl, 2H-1,2,3-triazolyl, 1H-1,2,4-triazolyl, 1H-tetrazolyl, 2H-tetrazolyl, pyridinyl, pyridin-2(1H)-one-yl, pyrazinyl, pyrimidinyl, pyrimidin-4(3H)-one-yl, pyridazinyl, pyridazin-3(2H)-one-yl, 1,2,4-triazinyl, 1, 3,5-Triazinyl, 1H-Indolyl, 1H-Indazolyl, 2H-Indazolyl, Indolizinyl, Benzofuranyl, Benzothienyl, 1H-Benzimidazolyl, 1,3-Benzoxazolyl, 1,3-Benzothiazolyl, 1,3-Benzodioxolyl, 1,2,3-Benzotriazolyl, 9H-Purinyl, Furo[3,2-b]pyridinyl, Furo[3,2-c]pyridinyl, Furo[2,3-c]pyridinyl, 1,3-Oxazolo[5,4-b]pyridinyl, Thieno[3,2-c]pyridinyl, Thieno[2,3-d]pyrimidinyl, 1H-Pyrrolo[ 2,3-b]pyridinyl, 1H-pyrrolo[2,3-c]pyridinyl, pyrrolo[1,2-a]pyrimidinyl, pyrrolo[1,2-a]pyrazinyl, pyrrolo[1,2-b]pyridazinyl, pyrazolo[1,5-a]pyridinyl, pyrazolo[1,5-a]pyrimidinyl, pyrazolo[1,5-a]pyrazinyl, 1H-pyrazolo[3,4-b]pyridinyl, 1H-pyrazolo[3,4-b]pyrazinyl, 1H-pyrazolo[3,4-c]pyridinyl, 1H-pyrazolo[4,3-b]pyridinyl, 1H-pyrazolo[4,3-d]pyrimidinyl, 2H-pyrazolo[4,3-b]pyridinyl Lysinyl, 2H-pyrazolo[4,3-c]pyridinyl, 5H-pyrrolo[2,3-b]pyrazinyl, imidazo[1,2-a]pyridinyl, imidazo[1,2-a]pyrazinyl, imidazo[1,2-a]pyrimidinyl, imidazo[1,2-b]pyridazinyl, imidazo[1,2-c]pyrimidinyl, 1H-imidazo[4,5-b]pyridinyl, 3H-imidazo[4,5-b]pyridinyl, imidazo[2,1-b][1,3]thiazolyl, imidazo[2,1-b][1,3,4]thiadiazolyl, [1,3]oxazolo[4,5-b]pyridinyl, [1,2,3]triazolo[1,5-a]pyridinyl, 1H-[1,2,3]triazolo[4,5-b]pyridinyl, 3H-[1,2,3]triazolo[4,5-b]pyridinyl, [1,2,4]triazolo[1,5-a]pyridinyl, [1,2,4]triazolo[1,5-a]pyridinyl, [1,2,4]triazolo[1,5-a]pyrazinyl, [1,2,4]triazolo[4,3-a]pyridinyl, tetrazolo[1,5-a]pyridinyl, tetrazolo[1,5-b]pyridazinyl, quinolinyl, isoquinolinyl, and quinoxalinyl, where available valences permit, one or two R, 1a This includes compounds of formula (I), formula (II), or formula (III) which may be substituted with a substituent.

[0117] Another aspect is R 1thienyl, 1H-pyrazolyl, 1H-imidazolyl, 1,3-thiazolyl, oxazolyl, 1,2,4-oxadiazolyl, 1,3,4-oxadiazolyl, 1,2,4-thiadiazolyl, 1H-1,2,3-triazolyl, 2H-1,2,3-triazolyl, 1H-1,2,4-triazolyl, 1H-tetrazolyl, 2H-tetrazolyl, pyridinyl, pyridin-2(1H)-one-yl, pyrazinyl, pyrimidinyl, pyrimidin-4(3H)-one-yl, pyridazinyl, pyridazin-3(2H)-one-yl, 1,2,4-triazinyl, 1, 3,5-Triazinyl, 1H-Indolyl, 1H-Indazolyl, 2H-Indazolyl, Indolizinyl, Benzofuranyl, Benzothienyl, 1H-Benzimidazolyl, 1,3-Benzoxazolyl, 1,3-Benzothiazolyl, 1,3-Benzodioxolyl, 1,2,3-Benzotriazolyl, 9H-Purinyl, Furo[3,2-b]pyridinyl, Furo[3,2-c]pyridinyl, Furo[2,3-c]pyridinyl, 1,3-Oxazolo[5,4-b]pyridinyl, Thieno[3,2-c]pyridinyl, Thieno[2,3-d]pyrimidinyl, 1H-Pyrrolo[ 2,3-b]pyridinyl, 1H-pyrrolo[2,3-c]pyridinyl, pyrrolo[1,2-a]pyrimidinyl, pyrrolo[1,2-a]pyrazinyl, pyrrolo[1,2-b]pyridazinyl, pyrazolo[1,5-a]pyridinyl, pyrazolo[1,5-a]pyrimidinyl, pyrazolo[1,5-a]pyrazinyl, 1H-pyrazolo[3,4-b]pyridinyl, 1H-pyrazolo[3,4-b]pyrazinyl, 1H-pyrazolo[3,4-c]pyridinyl, 1H-pyrazolo[4,3-b]pyridinyl, 1H-pyrazolo[4,3-d]pyrimidinyl, 2H-pyrazolo[4,3-b]pyridinyl Lysinyl, 2H-pyrazolo[4,3-c]pyridinyl, 5H-pyrrolo[2,3-b]pyrazinyl, imidazo[1,2-a]pyridinyl, imidazo[1,2-a]pyrazinyl, imidazo[1,2-a]pyrimidinyl, imidazo[1,2-b]pyridazinyl, imidazo[1,2-c]pyrimidinyl, 1H-imidazo[4,5-b]pyridinyl, 3H-imidazo[4,5-b]pyridinyl, imidazo[2,1-b][1,3]thiazolyl, imidazo[2,1-b][1,3,4]thiadiazolyl, [1,3]oxazolo[4,5-b]pyridinyl, [1,2,3]triazolo[1,5-a]pyridinyl, 1H-[1,2,3]triazolo[4,5-b]pyridinyl, 2H-[1,2,3]triazolo[4,5-b]pyridinyl, 3H-[1,2,3]triazolo[4,5-b]pyridinyl, [1,2,4]triazolo[1,5-a]pyridinyl, [1,2,4]triazolo[1,5-a]pyridinyl, [1,2,4]triazolo[4,3-a]pyridinyl, tetrazolo[1,5-a]pyridinyl, tetrazolo[1,5-b]pyridazinyl, quinolinyl, isoquinolinyl, and quinoxalinyl.

[0118] Another aspect is R 1thienyl, 1H-pyrazolyl, 1H-imidazolyl, 1,3-thiazolyl, oxazolyl, 1,2,4-oxadiazolyl, 1,3,4-oxadiazolyl, 1,2,4-thiadiazolyl, 1H-1,2,3-triazolyl, 2H-1,2,3-triazolyl, 1H-1,2,4-triazolyl, 1H-tetrazolyl, 2H-tetrazolyl, pyridinyl, pyridin-2(1H)-one-yl, pyrazinyl, pyrimidinyl, pyrimidin-4(3H)-one-yl, pyridazinyl, pyridazin-3(2H)-one-yl, 1,2,4-triazinyl, 1, 3,5-Triazinyl, 1H-Indolyl, 1H-Indazolyl, 2H-Indazolyl, Indolizinyl, Benzofuranyl, Benzothienyl, 1H-Benzimidazolyl, 1,3-Benzoxazolyl, 1,3-Benzothiazolyl, 1,3-Benzodioxolyl, 1,2,3-Benzotriazolyl, 9H-Purinyl, Furo[3,2-b]pyridinyl, Furo[3,2-c]pyridinyl, Furo[2,3-c]pyridinyl, 1,3-Oxazolo[5,4-b]pyridinyl, Thieno[3,2-c]pyridinyl, Thieno[2,3-d]pyrimidinyl, 1H-Pyrrolo[ 2,3-b]pyridinyl, 1H-pyrrolo[2,3-c]pyridinyl, pyrrolo[1,2-a]pyrimidinyl, pyrrolo[1,2-a]pyrazinyl, pyrrolo[1,2-b]pyridazinyl, pyrazolo[1,5-a]pyridinyl, pyrazolo[1,5-a]pyrimidinyl, pyrazolo[1,5-a]pyrazinyl, 1H-pyrazolo[3,4-b]pyridinyl, 1H-pyrazolo[3,4-b]pyrazinyl, 1H-pyrazolo[3,4-c]pyridinyl, 1H-pyrazolo[4,3-b]pyridinyl, 1H-pyrazolo[4,3-d]pyrimidinyl, 2H-pyrazolo[4,3-b]pyridinyl Lysinyl, 2H-pyrazolo[4,3-c]pyridinyl, 5H-pyrrolo[2,3-b]pyrazinyl, imidazo[1,2-a]pyridinyl, imidazo[1,2-a]pyrazinyl, imidazo[1,2-a]pyrimidinyl, imidazo[1,2-b]pyridazinyl, imidazo[1,2-c]pyrimidinyl, 1H-imidazo[4,5-b]pyridinyl, 3H-imidazo[4,5-b]pyridinyl, imidazo[2,1-b][1,3]thiazolyl, imidazo[2,1-b][1,3,4]thiadiazolyl, [1,3]oxazolo[4,5-b]pyridinyl, [1,2,3]triazolo[1,5-a]pyridinyl, 1H-[1,2,3]triazolo[4,5-b]pyridinyl, 2H-[1,2,3]triazolo[4,5-b]pyridinyl, 3H-[1,2,3]triazolo[4,5-b]pyridinyl, [1,2,4]triazolo[1,5-a]pyridinyl, [1,2,4]triazolo[1,5-a]pyridinyl, [1,2,4]triazolo[1,5-a]pyridazinyl, [1,2,4]triazolo[4,3-a]pyridinyl, tetrazolo[1,5-a]pyridinyl, tetrazolo[1,5-b]pyridazinyl, quinolinyl, isoquinolinyl, and quinoxalinyl, where available valences permit, one R, 1a This includes compounds of formula (I), formula (II), or formula (III) which are substituted with a substituent.

[0119] Another aspect is R 1thienyl, 1H-pyrazolyl, 1H-imidazolyl, 1,3-thiazolyl, oxazolyl, 1,2,4-oxadiazolyl, 1,3,4-oxadiazolyl, 1,2,4-thiadiazolyl, 1H-1,2,3-triazolyl, 2H-1,2,3-triazolyl, 1H-1,2,4-triazolyl, 1H-tetrazolyl, 2H-tetrazolyl, pyridinyl, pyridin-2(1H)-one-yl, pyrazinyl, pyrimidinyl, pyrimidin-4(3H)-one-yl, pyridazinyl, pyridazin-3(2H)-one-yl, 1,2,4-triazinyl, 1, 3,5-Triazinyl, 1H-Indolyl, 1H-Indazolyl, 2H-Indazolyl, Indolizinyl, Benzofuranyl, Benzothienyl, 1H-Benzimidazolyl, 1,3-Benzoxazolyl, 1,3-Benzothiazolyl, 1,3-Benzodioxolyl, 1,2,3-Benzotriazolyl, 9H-Purinyl, Furo[3,2-b]pyridinyl, Furo[3,2-c]pyridinyl, Furo[2,3-c]pyridinyl, 1,3-Oxazolo[5,4-b]pyridinyl, Thieno[3,2-c]pyridinyl, Thieno[2,3-d]pyrimidinyl, 1H-Pyrrolo[ 2,3-b]pyridinyl, 1H-pyrrolo[2,3-c]pyridinyl, pyrrolo[1,2-a]pyrimidinyl, pyrrolo[1,2-a]pyrazinyl, pyrrolo[1,2-b]pyridazinyl, pyrazolo[1,5-a]pyridinyl, pyrazolo[1,5-a]pyrimidinyl, pyrazolo[1,5-a]pyrazinyl, 1H-pyrazolo[3,4-b]pyridinyl, 1H-pyrazolo[3,4-b]pyrazinyl, 1H-pyrazolo[3,4-c]pyridinyl, 1H-pyrazolo[4,3-b]pyridinyl, 1H-pyrazolo[4,3-d]pyrimidinyl, 2H-pyrazolo[4,3-b]pyridinyl Lysinyl, 2H-pyrazolo[4,3-c]pyridinyl, 5H-pyrrolo[2,3-b]pyrazinyl, imidazo[1,2-a]pyridinyl, imidazo[1,2-a]pyrazinyl, imidazo[1,2-a]pyrimidinyl, imidazo[1,2-b]pyridazinyl, imidazo[1,2-c]pyrimidinyl, 1H-imidazo[4,5-b]pyridinyl, 3H-imidazo[4,5-b]pyridinyl, imidazo[2,1-b][1,3]thiazolyl, imidazo[2,1-b][1,3,4]thiadiazolyl, [1,3]oxazolo[4,5-b]pyridinyl, [1,2,3]triazolo[1,5-a]pyridinyl, 1H-[1,2,3]triazolo[4,5-b]pyridinyl, 2H-[1,2,3]triazolo[4,5-b]pyridinyl, 3H-[1,2,3]triazolo[4,5-b]pyridinyl, [1,2,4]triazolo[1,5-a]pyridinyl, [1,2,4]triazolo[1,5-a]pyridinyl, [1,2,4]triazolo[1,5-a]pyrazinyl, [1,2,4]triazolo[4,3-a]pyridinyl, tetrazolo[1,5-a]pyridinyl, tetrazolo[1,5-b]pyridazinyl, quinolinyl, isoquinolinyl, and quinoxalinyl, where available valences permit, two R, 1a This includes compounds of formula (I), formula (II), or formula (III) which are substituted with a substituent.

[0120] Another aspect is R 1 However, 1H-pyrazolyl, 1H-imidazolyl, 1,3-thiazolyl, oxazolyl, 1H-1,2,3-triazolyl, 2H-1,2,3-triazolyl, 1H-1,2,4-triazolyl, pyridinyl, pyridin-2(1H)-one-yl, pyrimidin-4(3H)-one-yl, pyridazinyl, 1H-indazolyl, 2H-indazolyl, 1,3-benzoxazolyl, pyrrolo[1,2-a]pyrazinyl, imidazolyl, Heteroaryl selected from [1,2-a]pyridinyl, imidazo[1,2-a]pyrazinyl, imidazo[1,2-a]pyrimidinyl, imidazo[1,2-b]pyridazinyl, 2H-[1,2,3]triazolo[4,5-b]pyridinyl, [1,2,4]triazolo[1,5-a]pyridinyl, and [1,2,4]triazolo[1,5-a]pyrazinyl, where available valences permit, one or two R 1a This includes compounds of formula (I), formula (II), or formula (III) which may be substituted with a substituent.

[0121] Another aspect is R 1However, 1H-pyrazolyl, 1H-imidazolyl, 1,3-thiazolyl, oxazolyl, 1H-1,2,3-triazolyl, 2H-1,2,3-triazolyl, 1H-1,2,4-triazolyl, pyridinyl, pyridin-2(1H)-one-yl, pyrimidin-4(3H)-one-yl, pyridazinyl, 1H-indazolyl, 2H-indazolyl, 1,3-benzoxazolyl, pyrrolo[1,2-a]pyrazinyl, imidazo[1, and [1,2,4]triazolo[1,5-a]pyridinyl, imidazo[1,2-a]pyrazinyl, imidazo[1,2-a]pyrimidinyl, imidazo[1,2-b]pyridazinyl, 2H-[1,2,3]triazolo[4,5-b]pyridinyl, [1,2,4]triazolo[1,5-a]pyridinyl, and [1,2,4]triazolo[1,5-a]pyrazinyl.

[0122] Another aspect is R 1 However, 1H-pyrazolyl, 1H-imidazolyl, 1,3-thiazolyl, oxazolyl, 1H-1,2,3-triazolyl, 2H-1,2,3-triazolyl, 1H-1,2,4-triazolyl, pyridinyl, pyridin-2(1H)-one-yl, pyrimidin-4(3H)-one-yl, pyridazinyl, 1H-indazolyl, 2H-indazolyl, 1,3-benzoxazolyl, pyrrolo[1,2-a]pyrazinyl, imidazolyl, heteroaryl selected from 2H-[1,2,3]triazolo[4,5-b]pyridinyl, [1,2,4]triazolo[1,5-a]pyridinyl, and [1,2,4]triazolo[1,5-a]pyrazinyl, where available valences permit, one R 1a This includes compounds of formula (I), formula (II), or formula (III) which are substituted with a substituent.

[0123] Another aspect is R 1However, 1H-pyrazolyl, 1H-imidazolyl, 1,3-thiazolyl, oxazolyl, 1H-1,2,3-triazolyl, 2H-1,2,3-triazolyl, 1H-1,2,4-triazolyl, pyridinyl, pyridin-2(1H)-one-yl, pyrimidin-4(3H)-one-yl, pyridazinyl, 1H-indazolyl, 2H-indazolyl, 1,3-benzoxazolyl, pyrrolo[1,2-a]pyrazinyl, imidazolyl, Heteroaryl selected from 2H-[1,2,3]triazolo[4,5-b]pyridinyl, [1,2,4]triazolo[1,5-a]pyridinyl, and [1,2,4]triazolo[1,5-a]pyrazinyl, where available valences permit, two R 1a This includes compounds of formula (I), formula (II), or formula (III) which are substituted with a substituent.

[0124] Another aspect is R 1Thien-2-yl, thien-3-yl, 1H-pyrazol-1-yl, 1H-pyrazol-3-yl, 1H-pyrazol-4-yl, 1H-pyrazol-5-yl, 1H-imidazol-1-yl, 1H-imidazol-4-yl, 1,3-thiazol-2-yl, 1,3-thiazol-5-yl, 1,3-oxazol-2-yl, 1,3-oxazol-4-yl, 1,3-oxazol-5-yl, 1,2,4-oxadiazol-3-yl, 1,3,4-oxadiazol-2-yl, 1,2,4-thiadiazol-5-yl, 1H-1, 2,3-Triazol-1-yl, 1H-1,2,3-triazol-4-yl, 1H-1,2,3-triazol-5-yl, 2H-1,2,3-triazol-2-yl, 2H-1,2,3-triazol-4-yl, 1H-1,2,4-triazol-1-yl, 1H-1,2,4-triazol-3-yl, 1H-1,2,4-triazol-5-yl, 1H-tetrazol-1-yl, 1H-tetrazol-5-yl, 2H-tetrazol-2-yl, 2H-tetrazol-5-yl, pyridin-2-yl, pyridin-3-yl, pyridin- 4-yl, pyridin-2(1H)-one-4-yl, pyridin-2(1H)-one-5-yl, pyridin-2(1H)-one-6-yl, pyrazin-2-yl, pyrazin-3-yl, pyrimidin-2-yl, pyrimidin-4-yl, pyrimidin-5-yl, pyrimidin-4(3H)-one-6-yl, pyridazin-3-yl, pyridazin-4-yl, pyridazin-3(2H)-one-5-yl, 1,2,4-triazin-3-yl, 1,3,5-triazin-2-yl, 1H-indol-3-yl, 1H-indol-4-yl, 1H-indol- 5-yl, 1H-indol-6-yl, 1H-indazol-5-yl, 1H-indazol-6-yl, 2H-indazol-4-yl, 2H-indazol-5-yl, 2H-indazol-6-yl, indolizin-2-yl, benzofuran-2-yl, benzofuran-5-yl, benzothien-2-yl, benzothien-3-yl, 1H-benzimidazol-2-yl, 1H-benzimidazol-5-yl, 1H-benzimidazol-6-yl, 1,3-benzoxazol-2-yl, 1,3-benzoxazol-5-yl, 1,3-Benzoxazol-6-yl, 1,3-benzothiazol-2-yl, 1,3-benzothiazol-5-yl, 1,3-benzothiazol-6-yl, 1,3-benzodioxol-5-yl, 1,2,3-benzotriazol-5-yl, 9H-purin-8-yl, furo[3,2-b]pyridin-2-yl, furo[3,2-c]pyridin-2-yl, furo[2,3-c]pyridin-2-yl, 1,3-oxazolo[5,4-b]pyridin-5-yl, thieno[3,2-c]pyridin-2-yl, thieno[2,3-d]pyrimidin-6-yl pyrrolo[2,3-b]pyridin-5-yl, 1H-pyrrolo[2,3-c]pyridin-4-yl, pyrrolo[1,2-a]pyrimidin-7-yl, pyrrolo[1,2-a]pyrazin-7-yl, pyrrolo[1,2-b]pyridazin-2-yl, pyrazolo[1,5-a]pyridin-2-yl, pyrazolo[1,5-a]pyridin-5-yl, pyrazolo[1,5-a]pyrazin-2-yl, pyrazolo[1,5-a]pyrimidin-2-yl, pyrazolo[1,5-a]pyrimidin-5-yl, 1H-pyrazolo[3,4-b]pyraz ... 1H-pyrazolo[3,4-b]pyridin-5-yl, 1H-pyrazolo[3,4-b]pyridin-6-yl, 1H-pyrazolo[3,4-c]pyridin-1-yl, 1H-pyrazolo[3,4-c]pyridin-5-yl, 1H-pyrazolo[4,3-b]pyridin-5-yl, 1H-pyrazolo[4,3-b]pyridin-6-yl, 1H-pyrazolo[4,3-d]pyrimidin-5-yl, 2H-pyrazolo[4,3-b]pyridin-5-yl, 2H-pyrazolo[4,3-c]pyridin-5-yl, 5H-pyrrolo[2,3-b]pyrazin-2-yl, imidazo[1,2-a ]pyridin-2-yl, imidazo[1,2-a]pyridin-6-yl, imidazo[1,2-a]pyrazin-2-yl, imidazo[1,2-a]pyrazin-6-yl, imidazo[1,2-a]pyrimidin-2-yl, imidazo[1,2-a]pyrimidin-6-yl, imidazo[1,2-b]pyridazin-2-yl, imidazo[1,2-b]pyridazin-6-yl, imidazo[1,2-c]pyrimidin-2-yl, 1H-imidazo[4,5-b]pyridin-5-yl, 3H-imidazo[4,5-b]pyridin-5-yl, imidazo[2,1-b][1,3]thiazol-6-yl, imidazo[2,1-b][1,3,4]thiadiazol-6-yl, [1,3]oxazolo[4,5-b]pyridin-2-yl, [1,2,3]triazolo[1,5-a]pyridin-5-yl, [1,2,3]triazolo[1,5-a]pyridin-6-yl, 1H-[1,2,3]triazolo[4,5-b]pyridin-5-yl, 2H-[1,2,3]triazolo[4,5-b]pyridin-6-yl, 3H-[1,2,3]triazolo[4,5-b]pyridin-5-yl, [1,2,4]triazolo[1,5-a]pyridin-2-yl, [1,2,4]triazolo[1,5-a]pyridin-6-yl, [1,2,4]thiazolo[1,5-a]pyridin-6-yl heteroaryl selected from riazolo[1,5-a]pyridin-7-yl, [1,2,4]triazolo[1,5-a]pyrazin-2-yl, [1,2,4]triazolo[1,5-a]pyrazin-5-yl, [1,2,4]triazolo[1,5-a]pyrazin-6-yl, [1,2,4]triazolo[4,3-a]pyridin-6-yl, [1,2,4]triazolo[4,3-a]pyridin-7-yl, tetrazolo[1,5-a]pyridin-7-yl, tetrazolo[1,5-b]pyridazin-7-yl, quinolin-6-yl, isoquinolin-6-yl, and quinoxalin-2-yl, where available valences permit, one or two R, 1a This includes compounds of formula (I), formula (II), or formula (III) which may be substituted with a substituent.

[0125] Another aspect is R 1Thien-2-yl, thien-3-yl, 1H-pyrazol-1-yl, 1H-pyrazol-3-yl, 1H-pyrazol-4-yl, 1H-pyrazol-5-yl, 1H-imidazol-1-yl, 1H-imidazol-4-yl, 1,3-thiazol-2-yl, 1,3-thiazol-5-yl, 1,3-oxazol-2-yl, 1,3-oxazol-4-yl, 1,3-oxazol-5-yl, 1,2,4-oxadiazol-3-yl, 1,3,4-oxadiazol-2-yl, 1,2,4-thiadiazol-5-yl, 1H-1, 2,3-Triazol-1-yl, 1H-1,2,3-triazol-4-yl, 1H-1,2,3-triazol-5-yl, 2H-1,2,3-triazol-2-yl, 2H-1,2,3-triazol-4-yl, 1H-1,2,4-triazol-1-yl, 1H-1,2,4-triazol-3-yl, 1H-1,2,4-triazol-5-yl, 1H-tetrazol-1-yl, 1H-tetrazol-5-yl, 2H-tetrazol-2-yl, 2H-tetrazol-5-yl, pyridin-2-yl, pyridin-3-yl, pyridin- 4-yl, pyridin-2(1H)-one-4-yl, pyridin-2(1H)-one-5-yl, pyridin-2(1H)-one-6-yl, pyrazin-2-yl, pyrazin-3-yl, pyrimidin-2-yl, pyrimidin-4-yl, pyrimidin-5-yl, pyrimidin-4(3H)-one-6-yl, pyridazin-3-yl, pyridazin-4-yl, pyridazin-3(2H)-one-5-yl, 1,2,4-triazin-3-yl, 1,3,5-triazin-2-yl, 1H-indol-3-yl, 1H-indol-4-yl, 1H-indol- 5-yl, 1H-indol-6-yl, 1H-indazol-5-yl, 1H-indazol-6-yl, 2H-indazol-4-yl, 2H-indazol-5-yl, 2H-indazol-6-yl, indolizin-2-yl, benzofuran-2-yl, benzofuran-5-yl, benzothien-2-yl, benzothien-3-yl, 1H-benzimidazol-2-yl, 1H-benzimidazol-5-yl, 1H-benzimidazol-6-yl, 1,3-benzoxazol-2-yl, 1,3-benzoxazol-5-yl, 1,3-Benzoxazol-6-yl, 1,3-benzothiazol-2-yl, 1,3-benzothiazol-5-yl, 1,3-benzothiazol-6-yl, 1,3-benzodioxol-5-yl, 1,2,3-benzotriazol-5-yl, 9H-purin-8-yl, furo[3,2-b]pyridin-2-yl, furo[3,2-c]pyridin-2-yl, furo[2,3-c]pyridin-2-yl, 1,3-oxazolo[5,4-b]pyridin-5-yl, thieno[3,2-c]pyridin-2-yl, thieno[2,3-d]pyrimidin-6-yl pyrrolo[2,3-b]pyridin-5-yl, 1H-pyrrolo[2,3-c]pyridin-4-yl, pyrrolo[1,2-a]pyrimidin-7-yl, pyrrolo[1,2-a]pyrazin-7-yl, pyrrolo[1,2-b]pyridazin-2-yl, pyrazolo[1,5-a]pyridin-2-yl, pyrazolo[1,5-a]pyridin-5-yl, pyrazolo[1,5-a]pyrazin-2-yl, pyrazolo[1,5-a]pyrimidin-2-yl, pyrazolo[1,5-a]pyrimidin-5-yl, 1H-pyrazolo[3,4-b]pyraz ... 1H-pyrazolo[3,4-b]pyridin-5-yl, 1H-pyrazolo[3,4-b]pyridin-6-yl, 1H-pyrazolo[3,4-c]pyridin-1-yl, 1H-pyrazolo[3,4-c]pyridin-5-yl, 1H-pyrazolo[4,3-b]pyridin-5-yl, 1H-pyrazolo[4,3-b]pyridin-6-yl, 1H-pyrazolo[4,3-d]pyrimidin-5-yl, 2H-pyrazolo[4,3-b]pyridin-5-yl, 2H-pyrazolo[4,3-c]pyridin-5-yl, 5H-pyrrolo[2,3-b]pyrazin-2-yl, imidazo[1,2-a ]pyridin-2-yl, imidazo[1,2-a]pyridin-6-yl, imidazo[1,2-a]pyrazin-2-yl, imidazo[1,2-a]pyrazin-6-yl, imidazo[1,2-a]pyrimidin-2-yl, imidazo[1,2-a]pyrimidin-6-yl, imidazo[1,2-b]pyridazin-2-yl, imidazo[1,2-b]pyridazin-6-yl, imidazo[1,2-c]pyrimidin-2-yl, 1H-imidazo[4,5-b]pyridin-5-yl, 3H-imidazo[4,5-b]pyridin-5-yl, imidazo[2,1-b][1,3]thiazol-6-yl, imidazo[2,1-b][1,3,4]thiadiazol-6-yl, [1,3]oxazolo[4,5-b]pyridin-2-yl, [1,2,3]triazolo[1,5-a]pyridin-5-yl, [1,2,3]triazolo[1,5-a]pyridin-6-yl, 1H-[1,2,3]triazolo[4,5-b]pyridin-5-yl, 2H-[1,2,3]triazolo[4,5-b]pyridin-6-yl, 3H-[1,2,3]triazolo[4,5-b]pyridin-5-yl, [1,2,4]triazolo[1,5-a]pyridin-2-yl, [1,2,4]triazolo[1,5-a]pyridin-6-yl, [1,2,4]triazolo[1,5-a]pyridin The present invention also includes compounds of formula (I), formula (II), or formula (III) in which the heteroaryl is selected from tetrazolo[1,5-a]pyridin-7-yl, [1,2,4]triazolo[1,5-a]pyrazin-2-yl, [1,2,4]triazolo[1,5-a]pyrazin-5-yl, [1,2,4]triazolo[1,5-a]pyrazin-6-yl, [1,2,4]triazolo[4,3-a]pyridin-6-yl, [1,2,4]triazolo[4,3-a]pyridin-7-yl, tetrazolo[1,5-a]pyridin-7-yl, tetrazolo[1,5-b]pyridazin-7-yl, quinolin-6-yl, isoquinolin-6-yl, and quinoxalin-2-yl.

[0126] Another aspect is R 1Thien-2-yl, thien-3-yl, 1H-pyrazol-1-yl, 1H-pyrazol-3-yl, 1H-pyrazol-4-yl, 1H-pyrazol-5-yl, 1H-imidazol-1-yl, 1H-imidazol-4-yl, 1,3-thiazol-2-yl, 1,3-thiazol-5-yl, 1,3-oxazol-2-yl, 1,3-oxazol-4-yl, 1,3-oxazol-5-yl, 1,2,4-oxadiazol-3-yl, 1,3,4-oxadiazol-2-yl, 1,2,4-thiadiazol-5-yl, 1H-1, 2,3-Triazol-1-yl, 1H-1,2,3-triazol-4-yl, 1H-1,2,3-triazol-5-yl, 2H-1,2,3-triazol-2-yl, 2H-1,2,3-triazol-4-yl, 1H-1,2,4-triazol-1-yl, 1H-1,2,4-triazol-3-yl, 1H-1,2,4-triazol-5-yl, 1H-tetrazol-1-yl, 1H-tetrazol-5-yl, 2H-tetrazol-2-yl, 2H-tetrazol-5-yl, pyridin-2-yl, pyridin-3-yl, pyridin- 4-yl, pyridin-2(1H)-one-4-yl, pyridin-2(1H)-one-5-yl, pyridin-2(1H)-one-6-yl, pyrazin-2-yl, pyrazin-3-yl, pyrimidin-2-yl, pyrimidin-4-yl, pyrimidin-5-yl, pyrimidin-4(3H)-one-6-yl, pyridazin-3-yl, pyridazin-4-yl, pyridazin-3(2H)-one-5-yl, 1,2,4-triazin-3-yl, 1,3,5-triazin-2-yl, 1H-indol-3-yl, 1H-indol-4-yl, 1H-indol- 5-yl, 1H-indol-6-yl, 1H-indazol-5-yl, 1H-indazol-6-yl, 2H-indazol-4-yl, 2H-indazol-5-yl, 2H-indazol-6-yl, indolizin-2-yl, benzofuran-2-yl, benzofuran-5-yl, benzothien-2-yl, benzothien-3-yl, 1H-benzimidazol-2-yl, 1H-benzimidazol-5-yl, 1H-benzimidazol-6-yl, 1,3-benzoxazol-2-yl, 1,3-benzoxazol-5-yl, 1,3-Benzoxazol-6-yl, 1,3-benzothiazol-2-yl, 1,3-benzothiazol-5-yl, 1,3-benzothiazol-6-yl, 1,3-benzodioxol-5-yl, 1,2,3-benzotriazol-5-yl, 9H-purin-8-yl, furo[3,2-b]pyridin-2-yl, furo[3,2-c]pyridin-2-yl, furo[2,3-c]pyridin-2-yl, 1,3-oxazolo[5,4-b]pyridin-5-yl, thieno[3,2-c]pyridin-2-yl, thieno[2,3-d]pyrimidin-6-yl pyrrolo[2,3-b]pyridin-5-yl, 1H-pyrrolo[2,3-c]pyridin-4-yl, pyrrolo[1,2-a]pyrimidin-7-yl, pyrrolo[1,2-a]pyrazin-7-yl, pyrrolo[1,2-b]pyridazin-2-yl, pyrazolo[1,5-a]pyridin-2-yl, pyrazolo[1,5-a]pyridin-5-yl, pyrazolo[1,5-a]pyrazin-2-yl, pyrazolo[1,5-a]pyrimidin-2-yl, pyrazolo[1,5-a]pyrimidin-5-yl, 1H-pyrazolo[3,4-b]pyraz ... 1H-pyrazolo[3,4-b]pyridin-5-yl, 1H-pyrazolo[3,4-b]pyridin-6-yl, 1H-pyrazolo[3,4-c]pyridin-1-yl, 1H-pyrazolo[3,4-c]pyridin-5-yl, 1H-pyrazolo[4,3-b]pyridin-5-yl, 1H-pyrazolo[4,3-b]pyridin-6-yl, 1H-pyrazolo[4,3-d]pyrimidin-5-yl, 2H-pyrazolo[4,3-b]pyridin-5-yl, 2H-pyrazolo[4,3-c]pyridin-5-yl, 5H-pyrrolo[2,3-b]pyrazin-2-yl, imidazo[1,2-a ]pyridin-2-yl, imidazo[1,2-a]pyridin-6-yl, imidazo[1,2-a]pyrazin-2-yl, imidazo[1,2-a]pyrazin-6-yl, imidazo[1,2-a]pyrimidin-2-yl, imidazo[1,2-a]pyrimidin-6-yl, imidazo[1,2-b]pyridazin-2-yl, imidazo[1,2-b]pyridazin-6-yl, imidazo[1,2-c]pyrimidin-2-yl, 1H-imidazo[4,5-b]pyridin-5-yl, 3H-imidazo[4,5-b]pyridin-5-yl, imidazo[2,1-b][1,3]thiazol-6-yl, imidazo[2,1-b][1,3,4]thiadiazol-6-yl, [1,3]oxazolo[4,5-b]pyridin-2-yl, [1,2,3]triazolo[1,5-a]pyridin-5-yl, [1,2,3]triazolo[1,5-a]pyridin-6-yl, 1H-[1,2,3]triazolo[4,5-b]pyridin-5-yl, 2H-[1,2,3]triazolo[4,5-b]pyridin-6-yl, 3H-[1,2,3]triazolo[4,5-b]pyridin-5-yl, [1,2,4]triazolo[1,5-a]pyridin-2-yl, [1,2,4]triazolo[1,5-a]pyridin-6-yl, [1,2,4 ]triazolo[1,5-a]pyridin-7-yl, [1,2,4]triazolo[1,5-a]pyrazin-2-yl, [1,2,4]triazolo[1,5-a]pyrazin-5-yl, [1,2,4]triazolo[1,5-a]pyrazin-6-yl, [1,2,4]triazolo[4,3-a]pyridin-6-yl, [1,2,4]triazolo[4,3-a]pyridin-7-yl, tetrazolo[1,5-a]pyridin-7-yl, tetrazolo[1,5-b]pyridazin-7-yl, quinolin-6-yl, isoquinolin-6-yl, and quinoxalin-2-yl, where available valences permit, one R, 1a This includes compounds of formula (I), formula (II), or formula (III) which are substituted with a substituent.

[0127] Another aspect is R 1Thien-2-yl, thien-3-yl, 1H-pyrazol-1-yl, 1H-pyrazol-3-yl, 1H-pyrazol-4-yl, 1H-pyrazol-5-yl, 1H-imidazol-1-yl, 1H-imidazol-4-yl, 1,3-thiazol-2-yl, 1,3-thiazol-5-yl, 1,3-oxazol-2-yl, 1,3-oxazol-4-yl, 1,3-oxazol-5-yl, 1,2,4-oxadiazol-3-yl, 1,3,4-oxadiazol-2-yl, 1,2,4-thiadiazol-5-yl, 1H-1, 2,3-Triazol-1-yl, 1H-1,2,3-triazol-4-yl, 1H-1,2,3-triazol-5-yl, 2H-1,2,3-triazol-2-yl, 2H-1,2,3-triazol-4-yl, 1H-1,2,4-triazol-1-yl, 1H-1,2,4-triazol-3-yl, 1H-1,2,4-triazol-5-yl, 1H-tetrazol-1-yl, 1H-tetrazol-5-yl, 2H-tetrazol-2-yl, 2H-tetrazol-5-yl, pyridin-2-yl, pyridin-3-yl, pyridin- 4-yl, pyridin-2(1H)-one-4-yl, pyridin-2(1H)-one-5-yl, pyridin-2(1H)-one-6-yl, pyrazin-2-yl, pyrazin-3-yl, pyrimidin-2-yl, pyrimidin-4-yl, pyrimidin-5-yl, pyrimidin-4(3H)-one-6-yl, pyridazin-3-yl, pyridazin-4-yl, pyridazin-3(2H)-one-5-yl, 1,2,4-triazin-3-yl, 1,3,5-triazin-2-yl, 1H-indol-3-yl, 1H-indol-4-yl, 1H-indol- 5-yl, 1H-indol-6-yl, 1H-indazol-5-yl, 1H-indazol-6-yl, 2H-indazol-4-yl, 2H-indazol-5-yl, 2H-indazol-6-yl, indolizin-2-yl, benzofuran-2-yl, benzofuran-5-yl, benzothien-2-yl, benzothien-3-yl, 1H-benzimidazol-2-yl, 1H-benzimidazol-5-yl, 1H-benzimidazol-6-yl, 1,3-benzoxazol-2-yl, 1,3-benzoxazol-5-yl, 1,3-Benzoxazol-6-yl, 1,3-benzothiazol-2-yl, 1,3-benzothiazol-5-yl, 1,3-benzothiazol-6-yl, 1,3-benzodioxol-5-yl, 1,2,3-benzotriazol-5-yl, 9H-purin-8-yl, furo[3,2-b]pyridin-2-yl, furo[3,2-c]pyridin-2-yl, furo[2,3-c]pyridin-2-yl, 1,3-oxazolo[5,4-b]pyridin-5-yl, thieno[3,2-c]pyridin-2-yl, thieno[2,3-d]pyrimidin-6-yl pyrrolo[2,3-b]pyridin-5-yl, 1H-pyrrolo[2,3-c]pyridin-4-yl, pyrrolo[1,2-a]pyrimidin-7-yl, pyrrolo[1,2-a]pyrazin-7-yl, pyrrolo[1,2-b]pyridazin-2-yl, pyrazolo[1,5-a]pyridin-2-yl, pyrazolo[1,5-a]pyridin-5-yl, pyrazolo[1,5-a]pyrazin-2-yl, pyrazolo[1,5-a]pyrimidin-2-yl, pyrazolo[1,5-a]pyrimidin-5-yl, 1H-pyrazolo[3,4-b]pyraz ... 1H-pyrazolo[3,4-b]pyridin-5-yl, 1H-pyrazolo[3,4-b]pyridin-6-yl, 1H-pyrazolo[3,4-c]pyridin-1-yl, 1H-pyrazolo[3,4-c]pyridin-5-yl, 1H-pyrazolo[4,3-b]pyridin-5-yl, 1H-pyrazolo[4,3-b]pyridin-6-yl, 1H-pyrazolo[4,3-d]pyrimidin-5-yl, 2H-pyrazolo[4,3-b]pyridin-5-yl, 2H-pyrazolo[4,3-c]pyridin-5-yl, 5H-pyrrolo[2,3-b]pyrazin-2-yl, imidazo[1,2-a ]pyridin-2-yl, imidazo[1,2-a]pyridin-6-yl, imidazo[1,2-a]pyrazin-2-yl, imidazo[1,2-a]pyrazin-6-yl, imidazo[1,2-a]pyrimidin-2-yl, imidazo[1,2-a]pyrimidin-6-yl, imidazo[1,2-b]pyridazin-2-yl, imidazo[1,2-b]pyridazin-6-yl, imidazo[1,2-c]pyrimidin-2-yl, 1H-imidazo[4,5-b]pyridin-5-yl, 3H-imidazo[4,5-b]pyridin-5-yl, imidazo[2,1-b][1,3]thiazol-6-yl, imidazo[2,1-b][1,3,4]thiadiazol-6-yl, [1,3]oxazolo[4,5-b]pyridin-2-yl, [1,2,3]triazolo[1,5-a]pyridin-5-yl, [1,2,3]triazolo[1,5-a]pyridin-6-yl, 1H-[1,2,3]triazolo[4,5-b]pyridin-5-yl, 2H-[1,2,3]triazolo[4,5-b]pyridin-6-yl, 3H-[1,2,3]triazolo[4,5-b]pyridin-5-yl, [1,2,4]triazolo[1,5-a]pyridin-2-yl, [1,2,4]triazolo[1,5-a]pyridin-6-yl, [1,2,4 ]triazolo[1,5-a]pyridin-7-yl, [1,2,4]triazolo[1,5-a]pyrazin-2-yl, [1,2,4]triazolo[1,5-a]pyrazin-5-yl, [1,2,4]triazolo[1,5-a]pyrazin-6-yl, [1,2,4]triazolo[4,3-a]pyridin-6-yl, [1,2,4]triazolo[4,3-a]pyridin-7-yl, tetrazolo[1,5-a]pyridin-7-yl, tetrazolo[1,5-b]pyridazin-7-yl, quinolin-6-yl, isoquinolin-6-yl, and quinoxalin-2-yl, where available valences permit, two R, 1a This includes compounds of formula (I), formula (II), or formula (III) which are substituted with a substituent.

[0128] Another aspect is R 11H-pyrazol-3-yl, 1H-pyrazol-4-yl, 1H-imidazol-1-yl, 1,3-thiazol-2-yl, 1,3-oxazol-2-yl, 1,3-oxazol-5-yl, 1H-1,2,3-triazol-1-yl, 2H-1,2,3-triazol-2-yl, 1H-1,2,4-triazol-1-yl, pyridin-4-yl, pyridin-2(1H)-one-4-yl, pyrimidin-4(3H)-one-6-yl, pyridazin-3-yl, 1H-indazol-5-yl, 2H-indazol-4-yl, 2H-indazol-5-yl, heteroaryl selected from 1,3-benzoxazol-6-yl, pyrrolo[1,2-a]pyrazin-7-yl, imidazo[1,2-a]pyridin-6-yl, imidazo[1,2-a]pyrazin-6-yl, imidazo[1,2-a]pyrimidin-6-yl, imidazo[1,2-b]pyridazin-6-yl, 2H-[1,2,3]triazolo[4,5-b]pyridin-6-yl, [1,2,4]triazolo[1,5-a]pyridin-6-yl, and [1,2,4]triazolo[1,5-a]pyrazin-2-yl, where available valences permit, one or two R 1a This includes compounds of formula (I), formula (II), or formula (III) which may be substituted with a substituent.

[0129] Another aspect is R 1However, 1H-pyrazol-3-yl, 1H-pyrazol-4-yl, 1H-imidazol-1-yl, 1,3-thiazol-2-yl, 1,3-oxazol-2-yl, 1,3-oxazol-5-yl, 1H-1,2,3-triazol-1-yl, 2H-1,2,3-triazol-2-yl, 1H-1,2,4-triazol-1-yl, pyridin-4-yl, pyridin-2(1H)-one-4-yl, pyrimidin-4(3H)-one-6-yl, pyridazin-3-yl, 1H-indazol-5-yl, 2H-indazol-4-yl, 2H-indazol-5-yl, 1,3 -benzoxazol-6-yl, pyrrolo[1,2-a]pyrazin-7-yl, imidazo[1,2-a]pyridin-6-yl, imidazo[1,2-a]pyrazin-6-yl, imidazo[1,2-a]pyrimidin-6-yl, imidazo[1,2-b]pyridazin-6-yl, 2H-[1,2,3]triazolo[4,5-b]pyridin-6-yl, [1,2,4]triazolo[1,5-a]pyridin-6-yl, and [1,2,4]triazolo[1,5-a]pyrazin-2-yl.

[0130] Another aspect is R 1However, 1H-pyrazol-3-yl, 1H-pyrazol-4-yl, 1H-imidazol-1-yl, 1,3-thiazol-2-yl, 1,3-oxazol-2-yl, 1,3-oxazol-5-yl, 1H-1,2,3-triazol-1-yl, 2H-1,2,3-triazol-2-yl, 1H-1,2,4-triazol-1-yl, pyridin-4-yl, pyridin-2(1H)-one-4-yl, pyrimidin-4(3H)-one-6-yl, pyridazin-3-yl, 1H-indazol-5-yl, 2H-indazol-4-yl, 2H-indazol-5-yl heteroaryl selected from among pyrrolo[1,2-a]pyrazin-7-yl, imidazo[1,2-a]pyridin-6-yl, imidazo[1,2-a]pyrazin-6-yl, imidazo[1,2-a]pyrimidin-6-yl, imidazo[1,2-b]pyridazin-6-yl, 2H-[1,2,3]triazolo[4,5-b]pyridin-6-yl, [1,2,4]triazolo[1,5-a]pyridin-6-yl, and [1,2,4]triazolo[1,5-a]pyrazin-2-yl, where available valences permit, one R 1a This includes compounds of formula (I), formula (II), or formula (III) which are substituted with a substituent.

[0131] Another aspect is R 1However, 1H-pyrazol-3-yl, 1H-pyrazol-4-yl, 1H-imidazol-1-yl, 1,3-thiazol-2-yl, 1,3-oxazol-2-yl, 1,3-oxazol-5-yl, 1H-1,2,3-triazol-1-yl, 2H-1,2,3-triazol-2-yl, 1H-1,2,4-triazol-1-yl, pyridin-4-yl, pyridin-2(1H)-one-4-yl, pyrimidin-4(3H)-one-6-yl, pyridazin-3-yl, 1H-indazol-5-yl, 2H-indazol-4-yl, 2H-indazol-5-yl , 1,3-benzoxazol-6-yl, pyrrolo[1,2-a]pyrazin-7-yl, imidazo[1,2-a]pyridin-6-yl, imidazo[1,2-a]pyrazin-6-yl, imidazo[1,2-a]pyrimidin-6-yl, imidazo[1,2-b]pyridazin-6-yl, 2H-[1,2,3]triazolo[[4,5-b]pyridin-6-yl, [1,2,4]triazolo[[1,5-a]pyridin-6-yl, and [1,2,4]triazolo[[1,5-a]pyrazin-2-yl, where available valences permit, two R 1a This includes compounds of formula (I), formula (II), or formula (III) which are substituted with a substituent.

[0132] Another aspect is R 1 Heteroaryl-C 2-4 alkenyl, Heteroaryl is a 3-7 membered monocyclic or 6-10 membered bicyclic ring system having 1, 2, 3, or 4 heteroatom ring members independently selected from N, O, or S, and heteroaryl may contain, where available valences permit, one or two R 1a It may be substituted with a substituent.

[0133] Another aspect is R 1 Heteroaryl-C 2-4and heteroaryl is thienyl, 1H-pyrazolyl, 1H-imidazolyl, 1,3-thiazolyl, oxazolyl, 1,2,4-oxadiazolyl, 1,3,4-oxadiazolyl, 1,2,4-thiadiazolyl, 1H-tetrazolyl, 2H-tetrazolyl, pyridinyl, pyrazinyl, pyrimidinyl, 1,2,4-triazolyl, 1H ... is selected from diphenyl, 1,3,5-triazinyl, 1H-indolyl, 1H-indazolyl, 2H-indazolyl, indolizinyl, benzofuranyl, benzothienyl, 1H-benzimidazolyl, 1,3-benzoxazolyl, 1,3-benzothiazolyl, 1,3-benzodioxolyl, 1,2,3-benzotriazolyl, 9H-purinyl, quinolinyl, isoquinolinyl, and quinoxalinyl; C 2-4 alkenyl is selected from ethenyl, propenyl, and butenyl; Heteroaryl may contain one or two R, where available valences permit. 1a It may be substituted with a substituent.

[0134] Another aspect is R 1 is 2-(1H-pyrazol-4-yl)ethenyl and, if permitted by available valences, one or two R 1a This includes compounds of formula (I), formula (II), or formula (III) which may be substituted with a substituent.

[0135] Another aspect is R 1is heteroaryl-amino, and heteroaryl is thienyl, 1H-pyrazolyl, 1H-imidazolyl, 1,3-thiazolyl, oxazolyl, 1,2,4-oxadiazolyl, 1,3,4-oxadiazolyl, 1,2,4-thiadiazolyl, 1H-tetrazolyl, 2H-tetrazolyl, pyridinyl, pyrazinyl, pyrimidinyl, pyridazinyl, 1,2,4-triazinyl, 1,3,5-triazinyl, 1H - selected from indolyl, 1H-indazolyl, 2H-indazolyl, indolizinyl, benzofuranyl, benzothienyl, 1H-benzimidazolyl, 1,3-benzoxazolyl, 1,3-benzothiazolyl, 1,3-benzodioxolyl, 1,2,3-benzotriazolyl, 9H-purinyl, quinolinyl, isoquinolinyl, and quinoxalinyl, where available valences permit, one or two R 1a This includes compounds of formula (I), formula (II), or formula (III) which may be substituted with a substituent.

[0136] Another aspect is R 1 are (pyridin-3-yl)amino, (pyrazin-2-yl)amino, and (pyrimidin-5-yl)amino, and, where available valences permit, one or two R 1a This includes compounds of formula (I), formula (II), or formula (III) which may be substituted with a substituent.

[0137] Another aspect is R 1 Heteroaryl-C 1-4The compounds of formula (I), (II), or (III) that are alkyl-amino, heteroaryl include thienyl, 1H-pyrazolyl, 1H-imidazolyl, 1,3-thiazolyl, oxazolyl, 1,2,4-oxadiazolyl, 1,3,4-oxadiazolyl, 1,2,4-thiadiazolyl, 1H-tetrazolyl, 2H-tetrazolyl, pyridinyl, pyrazinyl, pyrimidinyl, pyridazinyl, 1,2, selected from 4-triazinyl, 1,3,5-triazinyl, 1H-indolyl, 1H-indazolyl, 2H-indazolyl, indolizinyl, benzofuranyl, benzothienyl, 1H-benzimidazolyl, 1,3-benzoxazolyl, 1,3-benzothiazolyl, 1,3-benzodioxolyl, 1,2,3-benzotriazolyl, 9H-purinyl, quinolinyl, isoquinolinyl, and quinoxalinyl; C 1-4 alkyl is selected from methyl, ethyl, propyl, and butyl; Heteroaryl may contain one or two R, where available valences permit. 1a It may be substituted with a substituent.

[0138] Another aspect is R 1 is (1H-pyrazol-4-yl)methylamino, (pyridin-3-yl)methylamino, (pyridin-4-yl)methylamino, (quinolin-3-yl)methylamino, and (quinolin-8-yl)methylamino, where available valences permit, one or two R 1a This includes compounds of formula (I), formula (II), or formula (III) which may be substituted with a substituent.

[0139] In one embodiment, R 1a But halogen, hydroxyl, cyano, C 1-4 Alkyl, Deuterium-C 1-4 Alkyl, halo-C 1-4 Alkyl, Amino, C 1-4 Alkyl-amino, (C 1-4 Alkyl) 2 - Amino, C 1-4 Alkoxy, Deuterium-C 1-4 Alkoxy, and halo-C1-4 The present invention includes compounds of formula (I), formula (II), or formula (III) wherein:

[0140] Another aspect is R 1a But halogen, cyano, C 1-4 Alkyl, Deuterium-C 1-4 Alkyl, halo-C 1-4 Alkyl, C 1-4 Alkoxy, and Deuterium-C 1-4 The present invention includes compounds of formula (I), formula (II), or formula (III) wherein:

[0141] Another aspect is R 1a is selected from methyl, ethyl, propyl, isopropyl, butyl, and tert-butyl; 1-4 This includes compounds of formula (I), formula (II), or formula (III) in which:

[0142] Another aspect is R 1a is selected from methyl and ethyl.

[0143] Another aspect is R 1a is methyl.

[0144] Another aspect is R 1a is ethyl.

[0145] Another aspect is R 1a is a halogen selected from bromo, chloro, fluoro, and iodo.

[0146] Another aspect is R 1a is fluoro.

[0147] Another aspect is R 1ais cyano.

[0148] Another aspect is R 1a But deuterium C 1-4 Alkyl, C 1-4 Alkyl includes compounds of formula (I), formula (II), or formula (III) selected from methyl, ethyl, propyl, isopropyl, butyl, and tert-butyl, which are partially or fully substituted with one or more deuterium atoms, where available valences permit.

[0149] Another aspect is R 1a but( 2 H 3 ) methyl.

[0150] Another aspect is R 1a But, Halo-C 1-4 Alkyl, C 1-4 Alkyl includes compounds of formula (I), formula (II), or formula (III) selected from methyl, ethyl, propyl, isopropyl, butyl, and tert-butyl, which are partially or fully substituted with one or more halogen atoms, where available valences permit.

[0151] Another aspect is R 1a is trifluoromethyl.

[0152] Another aspect is R 1a is selected from methoxy, ethoxy, propoxy, isopropoxy, butoxy and tert-butoxy 1-4 Includes compounds of formula (I), formula (II), or formula (III) which are alkoxy.

[0153] Another aspect is R 1a is methoxy.

[0154] Another aspect is R 1a But deuterium C 1-4 Alkoxy, C 1-4 Alkoxy includes compounds of formula (I), formula (II), or formula (III) selected from methoxy, ethoxy, propoxy, isopropoxy, butoxy, and tert-butoxy, which are partially or fully substituted with one or more deuterium atoms, where available valences permit.

[0155] Another aspect is R 1a but( 2 H 3 ) methoxy.

[0156] Another aspect herein includes a compound of formula (I), or a form thereof. [ka] (In the formula, X is O, NR x , or a bond, R x is hydrogen and C 1-4 alkyl, B is heterocyclyl; Heterocyclyl is a saturated or partially unsaturated 3- to 7-membered monocyclic, 6- to 10-membered bicyclic, or 13- to 16-membered polycyclic ring system having 1, 2, or 3 heteroatom ring members independently selected from N, O, or S, and, where permitted by available valences, 1, 2, 3, 4, or 5 R b each of which may be substituted with a substituent; R b is a halogen, C 1-4 Alkyl, Amino, C 1-4 Alkyl-amino, (C 1-4 Alkyl) 2 -Amino and C 3-6 cycloalkyl; R 1 Heteroaryl, heterocyclyl, phenyl, heteroaryl-C 1-4Alkyl, Heteroaryl-C 2-4 Alkenyl, Heteroaryl-amino, Heteroaryl-C 1-4 alkyl-amino; Heteroaryl is a 3-7 membered monocyclic or 6-10 membered bicyclic ring system having 1, 2, 3, or 4 heteroatom ring members independently selected from N, O, or S; Heterocyclyl is a saturated or partially unsaturated 3- to 7-membered monocyclic, 6- to 10-membered bicyclic or 13- to 16-membered polycyclic ring system having 1, 2 or 3 heteroatom ring members independently selected from N, O or S; Each example of phenyl, heteroaryl, or heterocyclyl may have one or two R 1a may be substituted with a substituent; R 1a is halogen, hydroxyl, cyano, C 1-4 Alkyl, Deuterium-C 1-4 Alkyl, halo-C 1-4 Alkyl, Amino, C 1-4 Alkyl-amino, (C 1-4 Alkyl) 2 - Amino, C 1-4 Alkoxy, Deuterium-C 1-4 Alkoxy, and halo-C 1-4 alkoxy)

[0157] In one embodiment, X is O, NR x and a bond.

[0158] Another embodiment includes compounds of Formula (I) wherein X is O.

[0159] Another embodiment is where X is NR x

[0023] In particular, the present invention includes compounds of formula (I)

[0160] Another embodiment includes compounds of Formula (I) where X is a bond.

[0161] In one embodiment, R x But hydrogen and C1-4 The compounds of formula (I) include those in which the aryl group is selected from alkyl.

[0162] Another aspect is R x is hydrogen.

[0163] Another aspect is R x is selected from methyl, ethyl, propyl, isopropyl, butyl, and tert-butyl; 1-4 This includes compounds of formula (I) wherein:

[0164] Another aspect is R x is methyl.

[0165] In one embodiment, B is heterocyclyl, which is a saturated or partially unsaturated 3-7 membered monocyclic, 6-10 membered bicyclic, or 13-16 membered polycyclic ring system having 1, 2, or 3 heteroatom ring members independently selected from N, O, or S, and, where permitted by available valences, 1, 2, 3, 4, or 5 R b This includes compounds of formula (I) which may be substituted with substituents.

[0166] Another embodiment includes compounds of formula (I) where B is unsubstituted heterocyclyl, which is a saturated or partially unsaturated 3-7 membered monocyclic, 6-10 membered bicyclic, or 13-16 membered polycyclic ring system having 1, 2, or 3 heteroatom ring members independently selected from N, O, or S.

[0167] Another embodiment is where B is heterocyclyl, which is a saturated or partially unsaturated 3-7 membered monocyclic, 6-10 membered bicyclic, or 13-16 membered polycyclic ring system having 1, 2, or 3 heteroatom ring members independently selected from N, O, or S, and, where permitted by available valences, one R b This includes compounds of formula (I) which are substituted with a substituent.

[0168] Another embodiment is where B is heterocyclyl, which is a saturated or partially unsaturated 3-7 membered monocyclic, 6-10 membered bicyclic, or 13-16 membered polycyclic ring system having 1, 2, or 3 heteroatom ring members independently selected from N, O, or S, and where available valences permit, two R b Includes compounds of formula (I), each of which is substituted with a substituent.

[0169] Another embodiment is where B is heterocyclyl, which is a saturated or partially unsaturated 3-7 membered monocyclic, 6-10 membered bicyclic, or 13-16 membered polycyclic ring system having 1, 2, or 3 heteroatom ring members independently selected from N, O, or S, and, where permitted by available valences, three R b This includes compounds of formula (I) which are substituted with a substituent.

[0170] Another embodiment is where B is heterocyclyl, which is a saturated or partially unsaturated 3-7 membered monocyclic, 6-10 membered bicyclic, or 13-16 membered polycyclic ring system having 1, 2, or 3 heteroatom ring members independently selected from N, O, or S, and, where permitted by available valences, four R b This includes compounds of formula (I) which are substituted with a substituent.

[0171] Another embodiment is where B is heterocyclyl, which is a saturated or partially unsaturated 3-7 membered monocyclic, 6-10 membered bicyclic, or 13-16 membered polycyclic ring system having 1, 2, or 3 heteroatom ring members independently selected from N, O, or S, and where available valences permit, five R b This includes compounds of formula (I) which are substituted with a substituent.

[0172] Another embodiment is where B is azetidinyl, tetrahydrofuranyl, pyrrolidinyl, piperidinyl, piperidin-1-olate-yl, piperazinyl, 1,4-diazepanyl, 1,2-dihydropyridinyl, 1,2,5,6-tetrahydropyridinyl, 1,2,3,6-tetrahydropyridinyl, hexahydrocyclopentapyrrol-(1H)-yl, hexahydropyrrolo[3,2-b]pyrrol-(2H)-yl, hexahydropyrrolo[3,4-b]pyrrol-(2H)-yl, octahydro-2H-pyrrolo[3,4-c]pyridinyl, octahydro-5H- Pyrrolo[3,2-c]pyridinyl, octahydro-6H-pyrrolo[3,4-b]pyridinyl, hexahydropyrrolo[1,2-a]pyrazin-(2H)-one, hexahydropyrrolo[1,2-a]pyrazin-(1H)-yl, hexahydro-1H-cyclobuta[1.2-c:1,4-c′]dipyrrol-(3H)-yl, octahydropyrrolo[1,2-a]pyrazin-(1H)-yl, octahydro-2H-pyrido[1,2-a]pyrazinyl, hexahydropyrrolo[3,4-b][1,4]oxazin-(2H)-yl, 5-azaspiro[2.4]hepta nyl, 1-azaspiro[3.3]heptanyl, 4-azaspiro[2.5]octanyl, 2-oxa-6-azaspiro[3.4]octanyl, 3-azabicyclo[3.1.0]hexanyl, 8-azabicyclo[3.2.1]octanyl, 8-azabicyclo[3.2.1]oct-2-en-yl, 9-azabicyclo[3.3.1]nonanyl, 2,5-diazabicyclo[2.2.1]heptanyl, 1,4-diazabicyclo[3.1.1]heptanyl, 3,6-diazabicyclo[3.2.0]heptanyl, 2,5-diazabicyclo[2.2.2]octanyl, 1,4-diazabicyclo[3.2.1]octanyl, 3,8-diazabicyclo[3.2.1]octanyl, 1,4-diazabicyclo[3.2.2]nonanyl, 4,7-diazaspiro[2.5]octanyl, 2,6-diazaspiro[3.3]heptanyl, 1,6-diazaspiro[3.4]octanyl, 2,6-diazaspiro[3.4]octanyl, 1,7-diazaspiro[4.4]nonanyl, 1,7-diazaspiro[3.5]nonanyl, 2,6-diazaspiro[3.5]nonanyl, 2,7-diazaspiro[3.5]nonanyl, 5,8-diazaspiro[3.5]nonanyl, 2-oxa-5,8-diazaspiro[3.5]nonanyl, 2,7-diazaspiro[4.4]nonanyl, 2,7-diazaspiro[4.5]decanyl, 2,8-diazaspiro[4.5]decanyl, 6,9-diazaspiro[4.5]decyl, 6-oxa-2,9-diazaspiro[4.5]decanyl, 2,9-diazaspiro[5.5]undecanyl, 4-azadispiro[2.1.2. 5 .3 3 ]decanyl, and 7-azadispiro[5.1.5 8 .3 6 ]hexadecanyl, where available valences permit, one, two, three, four or five R b This includes compounds of formula (I) which may be substituted with substituents.

[0173] Another embodiment is where B is azetidinyl, tetrahydrofuranyl, pyrrolidinyl, piperidinyl, piperidin-1-olate-yl, piperazinyl, 1,4-diazepanyl, 1,2-dihydropyridinyl, 1,2,5,6-tetrahydropyridinyl, 1,2,3,6-tetrahydropyridinyl, hexahydrocyclopentapyrrol-(1H)-yl, hexahydropyrrolo[3,2-b]pyrrol-(2H)-yl, hexahydropyrrolo[3,4-b]pyrrol-(2H)-yl, octahydro-2H-pyrrolo[3,4-c]pyridinyl, octahydro-5H- Pyrrolo[3,2-c]pyridinyl, octahydro-6H-pyrrolo[3,4-b]pyridinyl, hexahydropyrrolo[1,2-a]pyrazin-(2H)-one, hexahydropyrrolo[1,2-a]pyrazin-(1H)-yl, hexahydro-1H-cyclobuta[1.2-c:1,4-c′]dipyrrol-(3H)-yl, octahydropyrrolo[1,2-a]pyrazin-(1H)-yl, octahydro-2H-pyrido[1,2-a]pyrazinyl, hexahydropyrrolo[3,4-b][1,4]oxazin-(2H)-yl, 5-azaspiro[2.4]hepta nyl, 1-azaspiro[3.3]heptanyl, 4-azaspiro[2.5]octanyl, 2-oxa-6-azaspiro[3.4]octanyl, 3-azabicyclo[3.1.0]hexanyl, 8-azabicyclo[3.2.1]octanyl, 8-azabicyclo[3.2.1]oct-2-en-yl, 9-azabicyclo[3.3.1]nonanyl, 2,5-diazabicyclo[2.2.1]heptanyl, 1,4-diazabicyclo[3.1.1]heptanyl, 3,6-diazabicyclo[3.2.0]heptanyl, 2,5-diazabicyclo[2.2.2]octanyl, 1,4-diazabicyclo[3.2.1]octanyl, 3,8-diazabicyclo[3.2.1]octanyl, 1,4-diazabicyclo[3.2.2]nonanyl, 4,7-diazaspiro[2.5]octanyl, 2,6-diazaspiro[3.3]heptanyl, 1,6-diazaspiro[3.4]octanyl, 2,6-diazaspiro[3.4]octanyl, 1,7-diazaspiro[4.4]nonanyl, 1,7-diazaspiro[3.5]nonanyl, 2,6-diazaspiro[3.5]nonanyl, 2,7-diazaspiro[3.5]nonanyl, 5,8-diazaspiro[3.5]nonanyl, 2-oxa-5,8-diazaspiro[3.5]nonanyl, 2,7-diazaspiro[4.4]nonanyl, 2,7-diazaspiro[4.5]decanyl, 2,8-diazaspiro[4.5]decanyl, 6,9-diazaspiro[4.5]decyl, 6-oxa-2,9-diazaspiro[4.5]decanyl, 2,9-diazaspiro[5.5]undecanyl, 4-azadispiro[2.1.2. 5 .3 3 ]decanyl, and 7-azadispiro[5.1.5 8 .3 6 ]hexadecanyl.

[0174] Another embodiment is where B is azetidinyl, tetrahydrofuranyl, pyrrolidinyl, piperidinyl, piperidin-1-olate-yl, piperazinyl, 1,4-diazepanyl, 1,2-dihydropyridinyl, 1,2,5,6-tetrahydropyridinyl, 1,2,3,6-tetrahydropyridinyl, hexahydrocyclopentapyrrol-(1H)-yl, hexahydropyrrolo[3,2-b]pyrrol-(2H)-yl, hexahydropyrrolo[3,4-b]pyrrol-(2H)-yl, octahydro-2H-pyrrolo[3,4-c]pyridinyl, octahydro-5H- Pyrrolo[3,2-c]pyridinyl, octahydro-6H-pyrrolo[3,4-b]pyridinyl, hexahydropyrrolo[1,2-a]pyrazin-(2H)-one, hexahydropyrrolo[1,2-a]pyrazin-(1H)-yl, hexahydro-1H-cyclobuta[1.2-c:1,4-c′]dipyrrol-(3H)-yl, octahydropyrrolo[1,2-a]pyrazin-(1H)-yl, octahydro-2H-pyrido[1,2-a]pyrazinyl, hexahydropyrrolo[3,4-b][1,4]oxazin-(2H)-yl, 5-azaspiro[2.4]hepta nyl, 1-azaspiro[3.3]heptanyl, 4-azaspiro[2.5]octanyl, 2-oxa-6-azaspiro[3.4]octanyl, 3-azabicyclo[3.1.0]hexanyl, 8-azabicyclo[3.2.1]octanyl, 8-azabicyclo[3.2.1]oct-2-en-yl, 9-azabicyclo[3.3.1]nonanyl, 2,5-diazabicyclo[2.2.1]heptanyl, 1,4-diazabicyclo[3.1.1]heptanyl, 3,6-diazabicyclo[3.2.0]heptanyl, 2,5-diazabicyclo[2.2.2]octanyl, 1,4-diazabicyclo[3.2.1]octanyl, 3,8-diazabicyclo[3.2.1]octanyl, 1,4-diazabicyclo[3.2.2]nonanyl, 4,7-diazaspiro[2.5]octanyl, 2,6-diazaspiro[3.3]heptanyl, 1,6-diazaspiro[3.4]octanyl, 2,6-diazaspiro[3.4]octanyl, 1,7-diazaspiro[4.4]nonanyl, 1,7-diazaspiro[3.5]nonanyl, 2,6-diazaspiro[3.5]nonanyl, 2,7-diazaspiro[3.5]nonanyl, 5,8-diazaspiro[3.5]nonanyl, 2-oxa-5,8-diazaspiro[3.5]nonanyl, 2,7-diazaspiro[4.4]nonanyl, 2,7-diazaspiro[4.5]decanyl, 2,8-diazaspiro[4.5]decanyl, 6,9-diazaspiro[4.5]decyl, 6-oxa-2,9-diazaspiro[4.5]decanyl, 2,9-diazaspiro[5.5]undecanyl, 4-azadispiro[2.1.2. 5 .3 3 ]decanyl, and 7-azadispiro[5.1.5 8 .3 6 ]hexadecanyl, where available valences permit, one R b This includes compounds of formula (I) which are substituted with a substituent.

[0175] Another embodiment is where B is azetidinyl, tetrahydrofuranyl, pyrrolidinyl, piperidinyl, piperidin-1-olate-yl, piperazinyl, 1,4-diazepanyl, 1,2-dihydropyridinyl, 1,2,5,6-tetrahydropyridinyl, 1,2,3,6-tetrahydropyridinyl, hexahydrocyclopentapyrrol-(1H)-yl, hexahydropyrrolo[3,2-b]pyrrol-(2H)-yl, hexahydropyrrolo[3,4-b]pyrrol-(2H)-yl, octahydro-2H-pyrrolo[3,4-c]pyridinyl, octahydro-5H- Pyrrolo[3,2-c]pyridinyl, octahydro-6H-pyrrolo[3,4-b]pyridinyl, hexahydropyrrolo[1,2-a]pyrazin-(2H)-one, hexahydropyrrolo[1,2-a]pyrazin-(1H)-yl, hexahydro-1H-cyclobuta[1.2-c:1,4-c′]dipyrrol-(3H)-yl, octahydropyrrolo[1,2-a]pyrazin-(1H)-yl, octahydro-2H-pyrido[1,2-a]pyrazinyl, hexahydropyrrolo[3,4-b][1,4]oxazin-(2H)-yl, 5-azaspiro[2.4]hepta nyl, 1-azaspiro[3.3]heptanyl, 4-azaspiro[2.5]octanyl, 2-oxa-6-azaspiro[3.4]octanyl, 3-azabicyclo[3.1.0]hexanyl, 8-azabicyclo[3.2.1]octanyl, 8-azabicyclo[3.2.1]oct-2-en-yl, 9-azabicyclo[3.3.1]nonanyl, 2,5-diazabicyclo[2.2.1]heptanyl, 1,4-diazabicyclo[3.1.1]heptanyl, 3,6-diazabicyclo[3.2.0]heptanyl, 2,5-diazabicyclo[2.2.2]octanyl, 1,4-diazabicyclo[3.2.1]octanyl, 3,8-diazabicyclo[3.2.1]octanyl, 1,4-diazabicyclo[3.2.2]nonanyl, 4,7-diazaspiro[2.5]octanyl, 2,6-diazaspiro[3.3]heptanyl, 1,6-diazaspiro[3.4]octanyl, 2,6-diazaspiro[3.4]octanyl, 1,7-diazaspiro[4.4]nonanyl, 1,7-diazaspiro[3.5]nonanyl, 2,6-diazaspiro[3.5]nonanyl, 2,7-diazaspiro[3.5]nonanyl, 5,8-diazaspiro[3.5]nonanyl, 2-oxa-5,8-diazaspiro[3.5]nonanyl, 2,7-diazaspiro[4.4]nonanyl, 2,7-diazaspiro[4.5]decanyl, 2,8-diazaspiro[4.5]decanyl, 6,9-diazaspiro[4.5]decyl, 6-oxa-2,9-diazaspiro[4.5]decanyl, 2,9-diazaspiro[5.5]undecanyl, 4-azadispiro[2.1.2. 5 .3 3 ]decanyl, and 7-azadispiro[5.1.5 8 .3 6 ]hexadecanyl, where available valences permit, two R b This includes compounds of formula (I) which are substituted with a substituent.

[0176] Another embodiment is where B is azetidinyl, tetrahydrofuranyl, pyrrolidinyl, piperidinyl, piperidin-1-olate-yl, piperazinyl, 1,4-diazepanyl, 1,2-dihydropyridinyl, 1,2,5,6-tetrahydropyridinyl, 1,2,3,6-tetrahydropyridinyl, hexahydrocyclopentapyrrol-(1H)-yl, hexahydropyrrolo[3,2-b]pyrrol-(2H)-yl, hexahydropyrrolo[3,4-b]pyrrol-(2H)-yl, octahydro-2H-pyrrolo[3,4-c]pyridinyl, octahydro-5H- Pyrrolo[3,2-c]pyridinyl, octahydro-6H-pyrrolo[3,4-b]pyridinyl, hexahydropyrrolo[1,2-a]pyrazin-(2H)-one, hexahydropyrrolo[1,2-a]pyrazin-(1H)-yl, hexahydro-1H-cyclobuta[1.2-c:1,4-c′]dipyrrol-(3H)-yl, octahydropyrrolo[1,2-a]pyrazin-(1H)-yl, octahydro-2H-pyrido[1,2-a]pyrazinyl, hexahydropyrrolo[3,4-b][1,4]oxazin-(2H)-yl, 5-azaspiro[2.4]hepta nyl, 1-azaspiro[3.3]heptanyl, 4-azaspiro[2.5]octanyl, 2-oxa-6-azaspiro[3.4]octanyl, 3-azabicyclo[3.1.0]hexanyl, 8-azabicyclo[3.2.1]octanyl, 8-azabicyclo[3.2.1]oct-2-en-yl, 9-azabicyclo[3.3.1]nonanyl, 2,5-diazabicyclo[2.2.1]heptanyl, 1,4-diazabicyclo[3.1.1]heptanyl, 3,6-diazabicyclo[3.2.0]heptanyl, 2,5-diazabicyclo[2.2.2]octanyl, 1,4-diazabicyclo[3.2.1]octanyl, 3,8-diazabicyclo[3.2.1]octanyl, 1,4-diazabicyclo[3.2.2]nonanyl, 4,7-diazaspiro[2.5]octanyl, 2,6-diazaspiro[3.3]heptanyl, 1,6-diazaspiro[3.4]octanyl, 2,6-diazaspiro[3.4]octanyl, 1,7-diazaspiro[4.4]nonanyl, 1,7-diazaspiro[3.5]nonanyl, 2,6-diazaspiro[3.5]nonanyl, 2,7-diazaspiro[3.5]nonanyl, 5,8-diazaspiro[3.5]nonanyl, 2-oxa-5,8-diazaspiro[3.5]nonanyl, 2,7-diazaspiro[4.4]nonanyl, 2,7-diazaspiro[4.5]decanyl, 2,8-diazaspiro[4.5]decanyl, 6,9-diazaspiro[4.5]decyl, 6-oxa-2,9-diazaspiro[4.5]decanyl, 2,9-diazaspiro[5.5]undecanyl, 4-azadispiro[2.1.2. 5 .3 3 ]decanyl, and 7-azadispiro[5.1.5 8 .3 6 ]hexadecanyl, where available valences permit, and three R b This includes compounds of formula (I) which are substituted with a substituent.

[0177] Another embodiment is where B is azetidinyl, tetrahydrofuranyl, pyrrolidinyl, piperidinyl, piperidin-1-olate-yl, piperazinyl, 1,4-diazepanyl, 1,2-dihydropyridinyl, 1,2,5,6-tetrahydropyridinyl, 1,2,3,6-tetrahydropyridinyl, hexahydrocyclopentapyrrol-(1H)-yl, hexahydropyrrolo[3,2-b]pyrrol-(2H)-yl, hexahydropyrrolo[3,4-b]pyrrol-(2H)-yl, octahydro-2H-pyrrolo[3,4-c]pyridinyl, octahydro-5H- Pyrrolo[3,2-c]pyridinyl, octahydro-6H-pyrrolo[3,4-b]pyridinyl, hexahydropyrrolo[1,2-a]pyrazin-(2H)-one, hexahydropyrrolo[1,2-a]pyrazin-(1H)-yl, hexahydro-1H-cyclobuta[1.2-c:1,4-c′]dipyrrol-(3H)-yl, octahydropyrrolo[1,2-a]pyrazin-(1H)-yl, octahydro-2H-pyrido[1,2-a]pyrazinyl, hexahydropyrrolo[3,4-b][1,4]oxazin-(2H)-yl, 5-azaspiro[2.4]hepta nyl, 1-azaspiro[3.3]heptanyl, 4-azaspiro[2.5]octanyl, 2-oxa-6-azaspiro[3.4]octanyl, 3-azabicyclo[3.1.0]hexanyl, 8-azabicyclo[3.2.1]octanyl, 8-azabicyclo[3.2.1]oct-2-en-yl, 9-azabicyclo[3.3.1]nonanyl, 2,5-diazabicyclo[2.2.1]heptanyl, 1,4-diazabicyclo[3.1.1]heptanyl, 3,6-diazabicyclo[3.2.0]heptanyl, 2,5-diazabicyclo[2.2.2]octanyl, 1,4-diazabicyclo[3.2.1]octanyl, 3,8-diazabicyclo[3.2.1]octanyl, 1,4-diazabicyclo[3.2.2]nonanyl, 4,7-diazaspiro[2.5]octanyl, 2,6-diazaspiro[3.3]heptanyl, 1,6-diazaspiro[3.4]octanyl, 2,6-diazaspiro[3.4]octanyl, 1,7-diazaspiro[4.4]nonanyl, 1,7-diazaspiro[3.5]nonanyl, 2,6-diazaspiro[3.5]nonanyl, 2,7-diazaspiro[3.5]nonanyl, 5,8-diazaspiro[3.5]nonanyl, 2-oxa-5,8-diazaspiro[3.5]nonanyl, 2,7-diazaspiro[4.4]nonanyl, 2,7-diazaspiro[4.5]decanyl, 2,8-diazaspiro[4.5]decanyl, 6,9-diazaspiro[4.5]decyl, 6-oxa-2,9-diazaspiro[4.5]decanyl, 2,9-diazaspiro[5.5]undecanyl, 4-azadispiro[2.1.2. 5 .3 3 ]decanyl, and 7-azadispiro[5.1.5 8 .3 6 ]hexadecanyl, where available valences permit, four R b This includes compounds of formula (I) which are substituted with a substituent.

[0178] Another embodiment is where B is azetidinyl, tetrahydrofuranyl, pyrrolidinyl, piperidinyl, piperidin-1-olate-yl, piperazinyl, 1,4-diazepanyl, 1,2-dihydropyridinyl, 1,2,5,6-tetrahydropyridinyl, 1,2,3,6-tetrahydropyridinyl, hexahydrocyclopentapyrrol-(1H)-yl, hexahydropyrrolo[3,2-b]pyrrol-(2H)-yl, hexahydropyrrolo[3,4-b]pyrrol-(2H)-yl, octahydro-2H-pyrrolo[3,4-c]pyridinyl, octahydro-5H- Pyrrolo[3,2-c]pyridinyl, octahydro-6H-pyrrolo[3,4-b]pyridinyl, hexahydropyrrolo[1,2-a]pyrazin-(2H)-one, hexahydropyrrolo[1,2-a]pyrazin-(1H)-yl, hexahydro-1H-cyclobuta[1.2-c:1,4-c′]dipyrrol-(3H)-yl, octahydropyrrolo[1,2-a]pyrazin-(1H)-yl, octahydro-2H-pyrido[1,2-a]pyrazinyl, hexahydropyrrolo[3,4-b][1,4]oxazin-(2H)-yl, 5-azaspiro[2.4]hepta nyl, 1-azaspiro[3.3]heptanyl, 4-azaspiro[2.5]octanyl, 2-oxa-6-azaspiro[3.4]octanyl, 3-azabicyclo[3.1.0]hexanyl, 8-azabicyclo[3.2.1]octanyl, 8-azabicyclo[3.2.1]oct-2-en-yl, 9-azabicyclo[3.3.1]nonanyl, 2,5-diazabicyclo[2.2.1]heptanyl, 1,4-diazabicyclo[3.1.1]heptanyl, 3,6-diazabicyclo[3.2.0]heptanyl, 2,5-diazabicyclo[2.2.2]octanyl, 1,4-diazabicyclo[3.2.1]octanyl, 3,8-diazabicyclo[3.2.1]octanyl, 1,4-diazabicyclo[3.2.2]nonanyl, 4,7-diazaspiro[2.5]octanyl, 2,6-diazaspiro[3.3]heptanyl, 1,6-diazaspiro[3.4]octanyl, 2,6-diazaspiro[3.4]octanyl, 1,7-diazaspiro[4.4]nonanyl, 1,7-diazaspiro[3.5]nonanyl, 2,6-diazaspiro[3.5]nonanyl, 2,7-diazaspiro[3.5]nonanyl, 5,8-diazaspiro[3.5]nonanyl, 2-oxa-5,8-diazaspiro[3.5]nonanyl, 2,7-diazaspiro[4.4]nonanyl, 2,7-diazaspiro[4.5]decanyl, 2,8-diazaspiro[4.5]decanyl, 6,9-diazaspiro[4.5]decyl, 6-oxa-2,9-diazaspiro[4.5]decanyl, 2,9-diazaspiro[5.5]undecanyl, 4-azadispiro[2.1.2. 5 .3 3 ]decanyl, and 7-azadispiro[5.1.5 8 .3 6 ]hexadecanyl, where available valences permit, five R b This includes compounds of formula (I) which are substituted with a substituent.

[0179] Another embodiment is where B is selected from the group consisting of pyrrolidinyl, piperidinyl, piperidin-1-olate-yl, piperazinyl, 4-azaspiro[2.5]octanyl, 8-azabicyclo[3.2.1]octanyl, 2,5-diazabicyclo[2.2.1]heptanyl, 1,6-diazaspiro[3.4]octanyl, 2-oxa-5,8-diazaspiro[3.5]nonanyl, and 4-azadispiro[2.1.2]octanyl. 5 .3 3 ]decanyl, where available valences permit, 1, 2, 3, 4 or 5 R b This includes compounds of formula (I) which may be substituted with substituents.

[0180] Another embodiment is where B is selected from the group consisting of pyrrolidinyl, piperidinyl, piperidin-1-olate-yl, piperazinyl, 4-azaspiro[2.5]octanyl, 8-azabicyclo[3.2.1]octanyl, 2,5-diazabicyclo[2.2.1]heptanyl, 1,6-diazaspiro[3.4]octanyl, 2-oxa-5,8-diazaspiro[3.5]nonanyl, and 4-azadispiro[2.1.2]octanyl. 5 .3 3 ]decanyl.

[0181] Another embodiment is where B is selected from the group consisting of pyrrolidinyl, piperidinyl, piperidin-1-olate-yl, piperazinyl, 4-azaspiro[2.5]octanyl, 8-azabicyclo[3.2.1]octanyl, 2,5-diazabicyclo[2.2.1]heptanyl, 1,6-diazaspiro[3.4]octanyl, 2-oxa-5,8-diazaspiro[3.5]nonanyl, and 4-azadispiro[2.1.2]octanyl. 5 .3 3 ]decanyl, where available valences permit, one R b This includes compounds of formula (I) which are substituted with a substituent.

[0182] Another embodiment is where B is selected from the group consisting of pyrrolidinyl, piperidinyl, piperidin-1-olate-yl, piperazinyl, 4-azaspiro[2.5]octanyl, 8-azabicyclo[3.2.1]octanyl, 2,5-diazabicyclo[2.2.1]heptanyl, 1,6-diazaspiro[3.4]octanyl, 2-oxa-5,8-diazaspiro[3.5]nonanyl, and 4-azadispiro[2.1.2]octanyl. 5 .3 3 ]decanyl, where available valences permit, two R b This includes compounds of formula (I) which are substituted with a substituent.

[0183] Another embodiment is where B is selected from the group consisting of pyrrolidinyl, piperidinyl, piperidin-1-olate-yl, piperazinyl, 4-azaspiro[2.5]octanyl, 8-azabicyclo[3.2.1]octanyl, 2,5-diazabicyclo[2.2.1]heptanyl, 1,6-diazaspiro[3.4]octanyl, 2-oxa-5,8-diazaspiro[3.5]nonanyl, and 4-azadispiro[2.1.2]octanyl. 5 .3 3 ]decanyl, where available valences permit, three R b This includes compounds of formula (I) which are substituted with a substituent.

[0184] Another embodiment is where B is selected from the group consisting of pyrrolidinyl, piperidinyl, piperidin-1-olate-yl, piperazinyl, 4-azaspiro[2.5]octanyl, 8-azabicyclo[3.2.1]octanyl, 2,5-diazabicyclo[2.2.1]heptanyl, 1,6-diazaspiro[3.4]octanyl, 2-oxa-5,8-diazaspiro[3.5]nonanyl, and 4-azadispiro[2.1.2]octanyl. 5 .3 3 ]decanyl, and, where available valences permit, four R b This includes compounds of formula (I) which are substituted with a substituent.

[0185] Another embodiment is where B is selected from the group consisting of pyrrolidinyl, piperidinyl, piperidin-1-olate-yl, piperazinyl, 4-azaspiro[2.5]octanyl, 8-azabicyclo[3.2.1]octanyl, 2,5-diazabicyclo[2.2.1]heptanyl, 1,6-diazaspiro[3.4]octanyl, 2-oxa-5,8-diazaspiro[3.5]nonanyl, and 4-azadispiro[2.1.2]octanyl. 5 .3 3 ]decanyl, and, where available valences permit, five R b This includes compounds of formula (I) which are substituted with a substituent.

[0186] Another embodiment is where B is heterocyclyl selected from pyrrolidinyl, piperidinyl, piperazinyl, and 4-azaspiro[2.5]octanyl, and where available valences permit, 1, 2, 3, 4, or 5 R b This includes compounds of formula (I) which may be substituted with substituents.

[0187] Another embodiment includes compounds of Formula (I) where B is unsubstituted heterocyclyl selected from pyrrolidinyl, piperidinyl, piperazinyl, and 4-azaspiro[2.5]octanyl.

[0188] Another embodiment is where B is heterocyclyl selected from pyrrolidinyl, piperidinyl, piperazinyl, and 4-azaspiro[2.5]octanyl, and where available valences permit, one R b This includes compounds of formula (I) which are substituted with a substituent.

[0189] Another embodiment is where B is heterocyclyl selected from pyrrolidinyl, piperidinyl, piperazinyl, and 4-azaspiro[2.5]octanyl, and where available valences permit, two R b This includes compounds of formula (I) which are substituted with a substituent.

[0190] Another embodiment is where B is heterocyclyl selected from pyrrolidinyl, piperidinyl, piperazinyl, and 4-azaspiro[2.5]octanyl, and where available valences permit, three R b This includes compounds of formula (I) which are substituted with a substituent.

[0191] Another embodiment is where B is heterocyclyl selected from pyrrolidinyl, piperidinyl, piperazinyl, and 4-azaspiro[2.5]octanyl, and where available valences permit, four R b This includes compounds of formula (I) which are substituted with a substituent.

[0192] Another embodiment is where B is heterocyclyl selected from pyrrolidinyl, piperidinyl, piperazinyl, and 4-azaspiro[2.5]octanyl, and where available valences permit, five R b This includes compounds of formula (I) which are substituted with a substituent.

[0193] Another embodiment is where B is pyrrolidinyl and, where available valences permit, one R b This includes compounds of formula (I) which are substituted with a substituent.

[0194] Another embodiment is where B is piperidinyl and, where available valences allow, 4 or 5 R bThis includes compounds of formula (I) which are substituted with a substituent.

[0195] Another embodiment is where B is piperidinyl and, where available valences allow, four R b This includes compounds of formula (I) which are substituted with a substituent.

[0196] Another embodiment is where B is piperidinyl and, where available valences permit, five R b This includes compounds of formula (I) which are substituted with a substituent.

[0197] Another embodiment includes compounds of Formula (I) where B is unsubstituted piperazinyl.

[0198] Another embodiment is where B is piperazinyl and, where available valences permit, one R b This includes compounds of formula (I) which are substituted with a substituent.

[0199] Another embodiment is where B is piperazinyl and where available valences allow, two R b This includes compounds of formula (I) which are substituted with a substituent.

[0200] Another embodiment is where B is piperazinyl and, where available valences allow, three R b This includes compounds of formula (I) which are substituted with a substituent.

[0201] Another embodiment is where B is piperazinyl and, where available valences allow, four R b This includes compounds of formula (I) which are substituted with a substituent.

[0202] Another embodiment includes compounds of Formula (I) where B is unsubstituted 4-azaspiro[2.5]octanyl.

[0203] Another embodiment is where B is 4-azaspiro[2.5]octanyl and, where available valences permit, one R bThis includes compounds of formula (I) which are substituted with a substituent.

[0204] Another embodiment is where B is 4-azaspiro[2.5]octanyl and, where available valences permit, two R b This includes compounds of formula (I) which are substituted with a substituent.

[0205] Another embodiment is where B is azetidin-1-yl, tetrahydrofuran-3-yl, pyrrolidin-1-yl, pyrrolidin-3-yl, piperidin-1-yl, piperidin-3-yl, piperidin-4-yl, piperidin-1-olate-4-yl, piperazin-1-yl, 1,4-diazepin-1-yl, 1,2-dihydropyridin-2-yl, 1,2-dihydropyridin-3-yl, 1,2-dihydropyridin-4-yl, 1,2-dihydropyridin-5-yl, 1,2-dihydropyridin-6-yl, 1,2,5,6-tetrahydropyridine-5-yl, 1,2,5,6-tetrahydropyridine ... -yl, 1,2,3,6-tetrahydropyridin-4-yl, hexahydrocyclopentapyrrol-2(1H)-yl, hexahydropyrrolo[3,2-b]pyrrol-1(2H)-yl, hexahydropyrrolo[3,4-b]pyrrol-1(2H)-yl, hexahydropyrrolo[3,4-c]pyrrol-1(1H)-yl, hexahydropyrrolo[3,4-c]pyrrol-2(1H)-yl, hexahydropyrrolo[3,4-c]pyrrol-5(1H)-yl, octahydro-5H-pyrrolo[3,2-c]pyridin-5-yl, octahydro-6H- Pyrrolo[3,4-b]pyridin-6-yl, hexahydropyrrolo[1,2-a]pyrazin-6(2H)-one, hexahydropyrrolo[1,2-a]pyrazin-2(1H)-yl, hexahydro-1H-cyclobuta[1.2-c:1,4-c′]dipyrrol-2(3H)-yl, octahydropyrrolo[1,2-a]pyrazin-2(1H)-yl, octahydro-2H-pyrido[1,2-a]pyrazin-2-yl, hexahydropyrrolo[3,4-b][1,4]oxazin-6(2H)-yl, 5-azaspiro[2.4]heptan-5-yl, 1- Azaspiro[3.3]heptan-2-yl, 4-azaspiro[2.5]octan-7-yl, 2-oxa-6-azaspiro[3.4]octan-6-yl, 3-azabicyclo[3.1.0]hexan-3-yl, 8-azabicyclo[3.2.1]octan-3-yl, 8-azabicyclo[3.2.1]oct-2-en-3-yl, 9-azabicyclo[3.3.1]nonan-3-yl, 2,5-diazabicyclo[2.2.1]heptan-2-yl, 1,4-diazabicyclo[3.1.1]heptan-4-yl, 3,6-diazabicyclo[3.2.0]heptan-3-yl, 3,6-diazabicyclo[3.2.0]heptan-6-yl, 2,5-diazabicyclo[2.2.2]octan-2-yl, 1,4-diazabicyclo[3.2.1]octan-4-yl, 3,8-diazabicyclo[3.2.1]octan-3-yl, 1,4-diazabicyclo[3.2.2]nonan-4-yl, 4,7-diazaspiro[2.5]octan-4-yl, 4,7-diazaspiro[2.5]octan-4-yl, 2,6-diazaspiro[3.3]heptan-2-yl, 1,6-diazaspiro[3.4]octan-6-yl, 2,6-diazaspiro[3.4]octan-2-yl, 2,6-diazaspiro[3.4]octan-6-yl, 1,7-diazaspiro[4.4]nonan-1-yl, 1,7-diazaspiro[4.4]nonan-7-yl, 1,7-diazaspiro[3.5]nonane- 7-yl, 2,6-diazaspiro[3.5]nonan-2-yl, 2,6-diazaspiro[3.5]nonan-6-yl, 1,7-diazaspiro[3.5]nonan-7-yl, 2,7-diazaspiro[3.5]nonan-2-yl, 2,7-diazaspiro[3.5]nonan-7-yl, 5,8-diazaspiro[3.5]nonan-8-yl, 2-oxa-5,8-diazaspiro[3.5]nonan-8-yl, 2,7-diaza Zaspiro[4.4]nonan-2-yl, 2,7-diazaspiro[4.5]decan-2-yl, 2,7-diazaspiro[4.5]decan-7-yl, 2,8-diazaspiro[4.5]decan-8-yl, 6,9-diazaspiro[4.5]decan-9-yl, 6-oxa-2,9-diazaspiro[4.5]decan-2-yl, 2,9-diazaspiro[5.5]undecan-9-yl, 4-azadispiro[2.1.2]undecan-2. 5 .3 3 ]decan-9-yl, and 7-azadispiro[5.1.5 8 .3 6 ]hexadecan-15-yl, where available valences permit, 1, 2, 3, 4 or 5 R b This includes compounds of formula (I) which may be substituted with substituents.

[0206] Another embodiment is where B is azetidin-1-yl, tetrahydrofuran-3-yl, pyrrolidin-1-yl, pyrrolidin-3-yl, piperidin-1-yl, piperidin-3-yl, piperidin-4-yl, piperidin-1-olate-4-yl, piperazin-1-yl, 1,4-diazepin-1-yl, 1,2-dihydropyridin-2-yl, 1,2-dihydropyridin-3-yl, 1,2-dihydropyridin-4-yl, 1,2-dihydropyridin-5-yl, 1,2-dihydropyridin-6-yl, 1,2,5,6-tetrahydropyridine-5-yl, 1,2,5,6-tetrahydropyridine ... -yl, 1,2,3,6-tetrahydropyridin-4-yl, hexahydrocyclopentapyrrol-2(1H)-yl, hexahydropyrrolo[3,2-b]pyrrol-1(2H)-yl, hexahydropyrrolo[3,4-b]pyrrol-1(2H)-yl, hexahydropyrrolo[3,4-c]pyrrol-1(1H)-yl, hexahydropyrrolo[3,4-c]pyrrol-2(1H)-yl, hexahydropyrrolo[3,4-c]pyrrol-5(1H)-yl, octahydro-5H-pyrrolo[3,2-c]pyridin-5-yl, octahydro-6H- Pyrrolo[3,4-b]pyridin-6-yl, hexahydropyrrolo[1,2-a]pyrazin-6(2H)-one, hexahydropyrrolo[1,2-a]pyrazin-2(1H)-yl, hexahydro-1H-cyclobuta[1.2-c:1,4-c′]dipyrrol-2(3H)-yl, octahydropyrrolo[1,2-a]pyrazin-2(1H)-yl, octahydro-2H-pyrido[1,2-a]pyrazin-2-yl, hexahydropyrrolo[3,4-b][1,4]oxazin-6(2H)-yl, 5-azaspiro[2.4]heptan-5-yl, 1- Azaspiro[3.3]heptan-2-yl, 4-azaspiro[2.5]octan-7-yl, 2-oxa-6-azaspiro[3.4]octan-6-yl, 3-azabicyclo[3.1.0]hexan-3-yl, 8-azabicyclo[3.2.1]octan-3-yl, 8-azabicyclo[3.2.1]oct-2-en-3-yl, 9-azabicyclo[3.3.1]nonan-3-yl, 2,5-diazabicyclo[2.2.1]heptan-2-yl, 1,4-diazabicyclo[3.1.1]heptan-4-yl, 3,6-diazabicyclo[3.2.0]heptan-3-yl, 3,6-diazabicyclo[3.2.0]heptan-6-yl, 2,5-diazabicyclo[2.2.2]octan-2-yl, 1,4-diazabicyclo[3.2.1]octan-4-yl, 3,8-diazabicyclo[3.2.1]octan-3-yl, 1,4-diazabicyclo[3.2.2]nonan-4-yl, 4,7-diazaspiro[2.5]octan-4-yl, 4,7-diazaspiro[2.5]octan-4-yl, 2,6-diazaspiro[3.3]heptan-2-yl, 1,6-diazaspiro[3.4]octan-6-yl, 2,6-diazaspiro[3.4]octan-2-yl, 2,6-diazaspiro[3.4]octan-6-yl, 1,7-diazaspiro[4.4]nonan-1-yl, 1,7-diazaspiro[4.4]nonan-7-yl, 1,7-diazaspiro[3.5]nonane- 7-yl, 2,6-diazaspiro[3.5]nonan-2-yl, 2,6-diazaspiro[3.5]nonan-6-yl, 1,7-diazaspiro[3.5]nonan-7-yl, 2,7-diazaspiro[3.5]nonan-2-yl, 2,7-diazaspiro[3.5]nonan-7-yl, 5,8-diazaspiro[3.5]nonan-8-yl, 2-oxa-5,8-diazaspiro[3.5]nonan-8-yl, 2,7-diaza Zaspiro[4.4]nonan-2-yl, 2,7-diazaspiro[4.5]decan-2-yl, 2,7-diazaspiro[4.5]decan-7-yl, 2,8-diazaspiro[4.5]decan-8-yl, 6,9-diazaspiro[4.5]decan-9-yl, 6-oxa-2,9-diazaspiro[4.5]decan-2-yl, 2,9-diazaspiro[5.5]undecan-9-yl, 4-azadispiro[2.1.2]undecan-2. 5 .3 3 ]decan-9-yl, and 7-azadispiro[5.1.5 8 .3 6 ]hexadecan-15-yl.

[0207] Another embodiment is where B is azetidin-1-yl, tetrahydrofuran-3-yl, pyrrolidin-1-yl, pyrrolidin-3-yl, piperidin-1-yl, piperidin-3-yl, piperidin-4-yl, piperidin-1-olate-4-yl, piperazin-1-yl, 1,4-diazepin-1-yl, 1,2-dihydropyridin-2-yl, 1,2-dihydropyridin-3-yl, 1,2-dihydropyridin-4-yl, 1,2-dihydropyridin-5-yl, 1,2-dihydropyridin-6-yl, 1,2,5,6-tetrahydropyridine-5-yl, 1,2,5,6-tetrahydropyridine ... -yl, 1,2,3,6-tetrahydropyridin-4-yl, hexahydrocyclopentapyrrol-2(1H)-yl, hexahydropyrrolo[3,2-b]pyrrol-1(2H)-yl, hexahydropyrrolo[3,4-b]pyrrol-1(2H)-yl, hexahydropyrrolo[3,4-c]pyrrol-1(1H)-yl, hexahydropyrrolo[3,4-c]pyrrol-2(1H)-yl, hexahydropyrrolo[3,4-c]pyrrol-5(1H)-yl, octahydro-5H-pyrrolo[3,2-c]pyridin-5-yl, octahydro-6H- Pyrrolo[3,4-b]pyridin-6-yl, hexahydropyrrolo[1,2-a]pyrazin-6(2H)-one, hexahydropyrrolo[1,2-a]pyrazin-2(1H)-yl, hexahydro-1H-cyclobuta[1.2-c:1,4-c′]dipyrrol-2(3H)-yl, octahydropyrrolo[1,2-a]pyrazin-2(1H)-yl, octahydro-2H-pyrido[1,2-a]pyrazin-2-yl, hexahydropyrrolo[3,4-b][1,4]oxazin-6(2H)-yl, 5-azaspiro[2.4]heptan-5-yl, 1- Azaspiro[3.3]heptan-2-yl, 4-azaspiro[2.5]octan-7-yl, 2-oxa-6-azaspiro[3.4]octan-6-yl, 3-azabicyclo[3.1.0]hexan-3-yl, 8-azabicyclo[3.2.1]octan-3-yl, 8-azabicyclo[3.2.1]oct-2-en-3-yl, 9-azabicyclo[3.3.1]nonan-3-yl, 2,5-diazabicyclo[2.2.1]heptan-2-yl, 1,4-diazabicyclo[3.1.1]heptan-4-yl, 3,6-diazabicyclo[3.2.0]heptan-3-yl, 3,6-diazabicyclo[3.2.0]heptan-6-yl, 2,5-diazabicyclo[2.2.2]octan-2-yl, 1,4-diazabicyclo[3.2.1]octan-4-yl, 3,8-diazabicyclo[3.2.1]octan-3-yl, 1,4-diazabicyclo[3.2.2]nonan-4-yl, 4,7-diazaspiro[2.5]octan-4-yl, 4,7-diazaspiro[2.5]octan-4-yl, 2,6-diazaspiro[3.3]heptan-2-yl, 1,6-diazaspiro[3.4]octan-6-yl, 2,6-diazaspiro[3.4]octan-2-yl, 2,6-diazaspiro[3.4]octan-6-yl, 1,7-diazaspiro[4.4]nonan-1-yl, 1,7-diazaspiro[4.4]nonan-7-yl, 1,7-diazaspiro[3.5]nonane- 7-yl, 2,6-diazaspiro[3.5]nonan-2-yl, 2,6-diazaspiro[3.5]nonan-6-yl, 1,7-diazaspiro[3.5]nonan-7-yl, 2,7-diazaspiro[3.5]nonan-2-yl, 2,7-diazaspiro[3.5]nonan-7-yl, 5,8-diazaspiro[3.5]nonan-8-yl, 2-oxa-5,8-diazaspiro[3.5]nonan-8-yl, 2,7-diaza Zaspiro[4.4]nonan-2-yl, 2,7-diazaspiro[4.5]decan-2-yl, 2,7-diazaspiro[4.5]decan-7-yl, 2,8-diazaspiro[4.5]decan-8-yl, 6,9-diazaspiro[4.5]decan-9-yl, 6-oxa-2,9-diazaspiro[4.5]decan-2-yl, 2,9-diazaspiro[5.5]undecan-9-yl, 4-azadispiro[2.1.2]undecan-2. 5 .3 3 ]decan-9-yl, and 7-azadispiro[5.1.5 8 .3 6 ]hexadecan-15-yl, and, if permitted by available valences, one R b This includes compounds of formula (I) which are substituted with a substituent.

[0208] Another embodiment is where B is azetidin-1-yl, tetrahydrofuran-3-yl, pyrrolidin-1-yl, pyrrolidin-3-yl, piperidin-1-yl, piperidin-3-yl, piperidin-4-yl, piperidin-1-olate-4-yl, piperazin-1-yl, 1,4-diazepin-1-yl, 1,2-dihydropyridin-2-yl, 1,2-dihydropyridin-3-yl, 1,2-dihydropyridin-4-yl, 1,2-dihydropyridin-5-yl, 1,2-dihydropyridin-6-yl, 1,2,5,6-tetrahydropyridine-5-yl, 1,2,5,6-tetrahydropyridine ... -yl, 1,2,3,6-tetrahydropyridin-4-yl, hexahydrocyclopentapyrrol-2(1H)-yl, hexahydropyrrolo[3,2-b]pyrrol-1(2H)-yl, hexahydropyrrolo[3,4-b]pyrrol-1(2H)-yl, hexahydropyrrolo[3,4-c]pyrrol-1(1H)-yl, hexahydropyrrolo[3,4-c]pyrrol-2(1H)-yl, hexahydropyrrolo[3,4-c]pyrrol-5(1H)-yl, octahydro-5H-pyrrolo[3,2-c]pyridin-5-yl, octahydro-6H- Pyrrolo[3,4-b]pyridin-6-yl, hexahydropyrrolo[1,2-a]pyrazin-6(2H)-one, hexahydropyrrolo[1,2-a]pyrazin-2(1H)-yl, hexahydro-1H-cyclobuta[1.2-c:1,4-c′]dipyrrol-2(3H)-yl, octahydropyrrolo[1,2-a]pyrazin-2(1H)-yl, octahydro-2H-pyrido[1,2-a]pyrazin-2-yl, hexahydropyrrolo[3,4-b][1,4]oxazin-6(2H)-yl, 5-azaspiro[2.4]heptan-5-yl, 1- Azaspiro[3.3]heptan-2-yl, 4-azaspiro[2.5]octan-7-yl, 2-oxa-6-azaspiro[3.4]octan-6-yl, 3-azabicyclo[3.1.0]hexan-3-yl, 8-azabicyclo[3.2.1]octan-3-yl, 8-azabicyclo[3.2.1]oct-2-en-3-yl, 9-azabicyclo[3.3.1]nonan-3-yl, 2,5-diazabicyclo[2.2.1]heptan-2-yl, 1,4-diazabicyclo[3.1.1]heptan-4-yl, 3,6-diazabicyclo[3.2.0]heptan-3-yl, 3,6-diazabicyclo[3.2.0]heptan-6-yl, 2,5-diazabicyclo[2.2.2]octan-2-yl, 1,4-diazabicyclo[3.2.1]octan-4-yl, 3,8-diazabicyclo[3.2.1]octan-3-yl, 1,4-diazabicyclo[3.2.2]nonan-4-yl, 4,7-diazaspiro[2.5]octan-4-yl, 4,7-diazaspiro[2.5]octan-4-yl, 2,6-diazaspiro[3.3]heptan-2-yl, 1,6-diazaspiro[3.4]octan-6-yl, 2,6-diazaspiro[3.4]octan-2-yl, 2,6-diazaspiro[3.4]octan-6-yl, 1,7-diazaspiro[4.4]nonan-1-yl, 1,7-diazaspiro[4.4]nonan-7-yl, 1,7-diazaspiro[3.5]nonane- 7-yl, 2,6-diazaspiro[3.5]nonan-2-yl, 2,6-diazaspiro[3.5]nonan-6-yl, 1,7-diazaspiro[3.5]nonan-7-yl, 2,7-diazaspiro[3.5]nonan-2-yl, 2,7-diazaspiro[3.5]nonan-7-yl, 5,8-diazaspiro[3.5]nonan-8-yl, 2-oxa-5,8-diazaspiro[3.5]nonan-8-yl, 2,7-diaza Zaspiro[4.4]nonan-2-yl, 2,7-diazaspiro[4.5]decan-2-yl, 2,7-diazaspiro[4.5]decan-7-yl, 2,8-diazaspiro[4.5]decan-8-yl, 6,9-diazaspiro[4.5]decan-9-yl, 6-oxa-2,9-diazaspiro[4.5]decan-2-yl, 2,9-diazaspiro[5.5]undecan-9-yl, 4-azadispiro[2.1.2]undecan-2. 5 .3 3 ]decan-9-yl, and 7-azadispiro[5.1.5 8 .3 6 ]hexadecan-15-yl, and where available valences permit, two R b This includes compounds of formula (I) which are substituted with a substituent.

[0209] Another embodiment is where B is azetidin-1-yl, tetrahydrofuran-3-yl, pyrrolidin-1-yl, pyrrolidin-3-yl, piperidin-1-yl, piperidin-3-yl, piperidin-4-yl, piperidin-1-olate-4-yl, piperazin-1-yl, 1,4-diazepin-1-yl, 1,2-dihydropyridin-2-yl, 1,2-dihydropyridin-3-yl, 1,2-dihydropyridin-4-yl, 1,2-dihydropyridin-5-yl, 1,2-dihydropyridin-6-yl, 1,2,5,6-tetrahydropyridine-5-yl, 1,2,5,6-tetrahydropyridine ... -yl, 1,2,3,6-tetrahydropyridin-4-yl, hexahydrocyclopentapyrrol-2(1H)-yl, hexahydropyrrolo[3,2-b]pyrrol-1(2H)-yl, hexahydropyrrolo[3,4-b]pyrrol-1(2H)-yl, hexahydropyrrolo[3,4-c]pyrrol-1(1H)-yl, hexahydropyrrolo[3,4-c]pyrrol-2(1H)-yl, hexahydropyrrolo[3,4-c]pyrrol-5(1H)-yl, octahydro-5H-pyrrolo[3,2-c]pyridin-5-yl, octahydro-6H- Pyrrolo[3,4-b]pyridin-6-yl, hexahydropyrrolo[1,2-a]pyrazin-6(2H)-one, hexahydropyrrolo[1,2-a]pyrazin-2(1H)-yl, hexahydro-1H-cyclobuta[1.2-c:1,4-c′]dipyrrol-2(3H)-yl, octahydropyrrolo[1,2-a]pyrazin-2(1H)-yl, octahydro-2H-pyrido[1,2-a]pyrazin-2-yl, hexahydropyrrolo[3,4-b][1,4]oxazin-6(2H)-yl, 5-azaspiro[2.4]heptan-5-yl, 1- Azaspiro[3.3]heptan-2-yl, 4-azaspiro[2.5]octan-7-yl, 2-oxa-6-azaspiro[3.4]octan-6-yl, 3-azabicyclo[3.1.0]hexan-3-yl, 8-azabicyclo[3.2.1]octan-3-yl, 8-azabicyclo[3.2.1]oct-2-en-3-yl, 9-azabicyclo[3.3.1]nonan-3-yl, 2,5-diazabicyclo[2.2.1]heptan-2-yl, 1,4-diazabicyclo[3.1.1]heptan-4-yl, 3,6-diazabicyclo[3.2.0]heptan-3-yl, 3,6-diazabicyclo[3.2.0]heptan-6-yl, 2,5-diazabicyclo[2.2.2]octan-2-yl, 1,4-diazabicyclo[3.2.1]octan-4-yl, 3,8-diazabicyclo[3.2.1]octan-3-yl, 1,4-diazabicyclo[3.2.2]nonan-4-yl, 4,7-diazaspiro[2.5]octan-4-yl, 4,7-diazaspiro[2.5]octan-4-yl, 2,6-diazaspiro[3.3]heptan-2-yl, 1,6-diazaspiro[3.4]octan-6-yl, 2,6-diazaspiro[3.4]octan-2-yl, 2,6-diazaspiro[3.4]octan-6-yl, 1,7-diazaspiro[4.4]nonan-1-yl, 1,7-diazaspiro[4.4]nonan-7-yl, 1,7-diazaspiro[3.5]nonane- 7-yl, 2,6-diazaspiro[3.5]nonan-2-yl, 2,6-diazaspiro[3.5]nonan-6-yl, 1,7-diazaspiro[3.5]nonan-7-yl, 2,7-diazaspiro[3.5]nonan-2-yl, 2,7-diazaspiro[3.5]nonan-7-yl, 5,8-diazaspiro[3.5]nonan-8-yl, 2-oxa-5,8-diazaspiro[3.5]nonan-8-yl, 2,7-diaza Zaspiro[4.4]nonan-2-yl, 2,7-diazaspiro[4.5]decan-2-yl, 2,7-diazaspiro[4.5]decan-7-yl, 2,8-diazaspiro[4.5]decan-8-yl, 6,9-diazaspiro[4.5]decan-9-yl, 6-oxa-2,9-diazaspiro[4.5]decan-2-yl, 2,9-diazaspiro[5.5]undecan-9-yl, 4-azadispiro[2.1.2]undecan-2. 5 .3 3 ]decan-9-yl, and 7-azadispiro[5.1.5 8 .3 6 ]hexadecan-15-yl, and where available valences permit, three R b This includes compounds of formula (I) which are substituted with a substituent.

[0210] Another embodiment is where B is azetidin-1-yl, tetrahydrofuran-3-yl, pyrrolidin-1-yl, pyrrolidin-3-yl, piperidin-1-yl, piperidin-3-yl, piperidin-4-yl, piperidin-1-olate-4-yl, piperazin-1-yl, 1,4-diazepin-1-yl, 1,2-dihydropyridin-2-yl, 1,2-dihydropyridin-3-yl, 1,2-dihydropyridin-4-yl, 1,2-dihydropyridin-5-yl, 1,2-dihydropyridin-6-yl, 1,2,5,6-tetrahydropyridine-5-yl, 1,2,5,6-tetrahydropyridine ... -yl, 1,2,3,6-tetrahydropyridin-4-yl, hexahydrocyclopentapyrrol-2(1H)-yl, hexahydropyrrolo[3,2-b]pyrrol-1(2H)-yl, hexahydropyrrolo[3,4-b]pyrrol-1(2H)-yl, hexahydropyrrolo[3,4-c]pyrrol-1(1H)-yl, hexahydropyrrolo[3,4-c]pyrrol-2(1H)-yl, hexahydropyrrolo[3,4-c]pyrrol-5(1H)-yl, octahydro-5H-pyrrolo[3,2-c]pyridin-5-yl, octahydro-6H- Pyrrolo[3,4-b]pyridin-6-yl, hexahydropyrrolo[1,2-a]pyrazin-6(2H)-one, hexahydropyrrolo[1,2-a]pyrazin-2(1H)-yl, hexahydro-1H-cyclobuta[1.2-c:1,4-c′]dipyrrol-2(3H)-yl, octahydropyrrolo[1,2-a]pyrazin-2(1H)-yl, octahydro-2H-pyrido[1,2-a]pyrazin-2-yl, hexahydropyrrolo[3,4-b][1,4]oxazin-6(2H)-yl, 5-azaspiro[2.4]heptan-5-yl, 1- Azaspiro[3.3]heptan-2-yl, 4-azaspiro[2.5]octan-7-yl, 2-oxa-6-azaspiro[3.4]octan-6-yl, 3-azabicyclo[3.1.0]hexan-3-yl, 8-azabicyclo[3.2.1]octan-3-yl, 8-azabicyclo[3.2.1]oct-2-en-3-yl, 9-azabicyclo[3.3.1]nonan-3-yl, 2,5-diazabicyclo[2.2.1]heptan-2-yl, 1,4-diazabicyclo[3.1.1]heptan-4-yl, 3,6-diazabicyclo[3.2.0]heptan-3-yl, 3,6-diazabicyclo[3.2.0]heptan-6-yl, 2,5-diazabicyclo[2.2.2]octan-2-yl, 1,4-diazabicyclo[3.2.1]octan-4-yl, 3,8-diazabicyclo[3.2.1]octan-3-yl, 1,4-diazabicyclo[3.2.2]nonan-4-yl, 4,7-diazaspiro[2.5]octan-4-yl, 4,7-diazaspiro[2.5]octan-4-yl, 2,6-diazaspiro[3.3]heptan-2-yl, 1,6-diazaspiro[3.4]octan-6-yl, 2,6-diazaspiro[3.4]octan-2-yl, 2,6-diazaspiro[3.4]octan-6-yl, 1,7-diazaspiro[4.4]nonan-1-yl, 1,7-diazaspiro[4.4]nonan-7-yl, 1,7-diazaspiro[3.5]nonane- 7-yl, 2,6-diazaspiro[3.5]nonan-2-yl, 2,6-diazaspiro[3.5]nonan-6-yl, 1,7-diazaspiro[3.5]nonan-7-yl, 2,7-diazaspiro[3.5]nonan-2-yl, 2,7-diazaspiro[3.5]nonan-7-yl, 5,8-diazaspiro[3.5]nonan-8-yl, 2-oxa-5,8-diazaspiro[3.5]nonan-8-yl, 2,7-diaza Zaspiro[4.4]nonan-2-yl, 2,7-diazaspiro[4.5]decan-2-yl, 2,7-diazaspiro[4.5]decan-7-yl, 2,8-diazaspiro[4.5]decan-8-yl, 6,9-diazaspiro[4.5]decan-9-yl, 6-oxa-2,9-diazaspiro[4.5]decan-2-yl, 2,9-diazaspiro[5.5]undecan-9-yl, 4-azadispiro[2.1.2]undecan-2. 5 .3 3 ]decan-9-yl, and 7-azadispiro[5.1.5 8 .3 6 ]hexadecan-15-yl, and, where available valences permit, four R b This includes compounds of formula (I) which are substituted with a substituent.

[0211] Another embodiment is where B is azetidin-1-yl, tetrahydrofuran-3-yl, pyrrolidin-1-yl, pyrrolidin-3-yl, piperidin-1-yl, piperidin-3-yl, piperidin-4-yl, piperidin-1-olate-4-yl, piperazin-1-yl, 1,4-diazepin-1-yl, 1,2-dihydropyridin-2-yl, 1,2-dihydropyridin-3-yl, 1,2-dihydropyridin-4-yl, 1,2-dihydropyridin-5-yl, 1,2-dihydropyridin-6-yl, 1,2,5,6-tetrahydropyridine-5-yl, 1,2,5,6-tetrahydropyridine ... -yl, 1,2,3,6-tetrahydropyridin-4-yl, hexahydrocyclopentapyrrol-2(1H)-yl, hexahydropyrrolo[3,2-b]pyrrol-1(2H)-yl, hexahydropyrrolo[3,4-b]pyrrol-1(2H)-yl, hexahydropyrrolo[3,4-c]pyrrol-1(1H)-yl, hexahydropyrrolo[3,4-c]pyrrol-2(1H)-yl, hexahydropyrrolo[3,4-c]pyrrol-5(1H)-yl, octahydro-5H-pyrrolo[3,2-c]pyridin-5-yl, octahydro-6H- Pyrrolo[3,4-b]pyridin-6-yl, hexahydropyrrolo[1,2-a]pyrazin-6(2H)-one, hexahydropyrrolo[1,2-a]pyrazin-2(1H)-yl, hexahydro-1H-cyclobuta[1.2-c:1,4-c′]dipyrrol-2(3H)-yl, octahydropyrrolo[1,2-a]pyrazin-2(1H)-yl, octahydro-2H-pyrido[1,2-a]pyrazin-2-yl, hexahydropyrrolo[3,4-b][1,4]oxazin-6(2H)-yl, 5-azaspiro[2.4]heptan-5-yl, 1- Azaspiro[3.3]heptan-2-yl, 4-azaspiro[2.5]octan-7-yl, 2-oxa-6-azaspiro[3.4]octan-6-yl, 3-azabicyclo[3.1.0]hexan-3-yl, 8-azabicyclo[3.2.1]octan-3-yl, 8-azabicyclo[3.2.1]oct-2-en-3-yl, 9-azabicyclo[3.3.1]nonan-3-yl, 2,5-diazabicyclo[2.2.1]heptan-2-yl, 1,4-diazabicyclo[3.1.1]heptan-4-yl, 3,6-diazabicyclo[3.2.0]heptan-3-yl, 3,6-diazabicyclo[3.2.0]heptan-6-yl, 2,5-diazabicyclo[2.2.2]octan-2-yl, 1,4-diazabicyclo[3.2.1]octan-4-yl, 3,8-diazabicyclo[3.2.1]octan-3-yl, 1,4-diazabicyclo[3.2.2]nonan-4-yl, 4,7-diazaspiro[2.5]octan-4-yl, 4,7-diazaspiro[2.5]octan-4-yl, 2,6-diazaspiro[3.3]heptan-2-yl, 1,6-diazaspiro[3.4]octan-6-yl, 2,6-diazaspiro[3.4]octan-2-yl, 2,6-diazaspiro[3.4]octan-6-yl, 1,7-diazaspiro[4.4]nonan-1-yl, 1,7-diazaspiro[4.4]nonan-7-yl, 1,7-diazaspiro[3.5]nonane- 7-yl, 2,6-diazaspiro[3.5]nonan-2-yl, 2,6-diazaspiro[3.5]nonan-6-yl, 1,7-diazaspiro[3.5]nonan-7-yl, 2,7-diazaspiro[3.5]nonan-2-yl, 2,7-diazaspiro[3.5]nonan-7-yl, 5,8-diazaspiro[3.5]nonan-8-yl, 2-oxa-5,8-diazaspiro[3.5]nonan-8-yl, 2,7-diaza Zaspiro[4.4]nonan-2-yl, 2,7-diazaspiro[4.5]decan-2-yl, 2,7-diazaspiro[4.5]decan-7-yl, 2,8-diazaspiro[4.5]decan-8-yl, 6,9-diazaspiro[4.5]decan-9-yl, 6-oxa-2,9-diazaspiro[4.5]decan-2-yl, 2,9-diazaspiro[5.5]undecan-9-yl, 4-azadispiro[2.1.2]undecan-2. 5 .3 3 ]decan-9-yl, and 7-azadispiro[5.1.5 8 .3 6 ]hexadecan-15-yl, and where available valences permit, five R b This includes compounds of formula (I) which are substituted with a substituent.

[0212] Another embodiment is where B is selected from the group consisting of pyrrolidin-1-yl, piperidin-4-yl, piperidin-1-olate-4-yl, piperazin-1-yl, 4-azaspiro[2.5]octan-7-yl, 8-azabicyclo[3.2.1]octan-3-yl, 2,5-diazabicyclo[2.2.1]heptan-2-yl, 1,6-diazaspiro[3.4]octan-6-yl, 2-oxa-5,8-diazaspiro[3.5]nonan-8-yl, and 4-azadispiro[2.1.2]octan-1-yl. 5 .3 3 ]decan-9-yl, where available valences permit, 1, 2, 3, 4 or 5 R b This includes compounds of formula (I) which may be substituted with substituents.

[0213] Another embodiment is where B is selected from the group consisting of pyrrolidin-1-yl, piperidin-4-yl, piperidin-1-olate-4-yl, piperazin-1-yl, 4-azaspiro[2.5]octan-7-yl, 8-azabicyclo[3.2.1]octan-3-yl, 2,5-diazabicyclo[2.2.1]heptan-2-yl, 1,6-diazaspiro[3.4]octan-6-yl, 2-oxa-5,8-diazaspiro[3.5]nonan-8-yl, and 4-azadispiro[2.1.2]octan-1-yl. 5 .3 3 ]decan-9-yl.

[0214] Another embodiment is where B is selected from the group consisting of pyrrolidin-1-yl, piperidin-4-yl, piperidin-1-olate-4-yl, piperazin-1-yl, 4-azaspiro[2.5]octan-7-yl, 8-azabicyclo[3.2.1]octan-3-yl, 2,5-diazabicyclo[2.2.1]heptan-2-yl, 1,6-diazaspiro[3.4]octan-6-yl, 2-oxa-5,8-diazaspiro[3.5]nonan-8-yl, and 4-azadispiro[2.1.2]octan-1-yl. 5 .3 3 ]decan-9-yl, and, if permitted by available valences, one R bThis includes compounds of formula (I) which are substituted with a substituent.

[0215] Another embodiment is where B is selected from the group consisting of pyrrolidin-1-yl, piperidin-4-yl, piperidin-1-olate-4-yl, piperazin-1-yl, 4-azaspiro[2.5]octan-7-yl, 8-azabicyclo[3.2.1]octan-3-yl, 2,5-diazabicyclo[2.2.1]heptan-2-yl, 1,6-diazaspiro[3.4]octan-6-yl, 2-oxa-5,8-diazaspiro[3.5]nonan-8-yl, and 4-azadispiro[2.1.2]octan-1-yl. 5 .3 3 ]decan-9-yl, and where available valences permit, two R b This includes compounds of formula (I) which are substituted with a substituent.

[0216] Another embodiment is where B is selected from the group consisting of pyrrolidin-1-yl, piperidin-4-yl, piperidin-1-olate-4-yl, piperazin-1-yl, 4-azaspiro[2.5]octan-7-yl, 8-azabicyclo[3.2.1]octan-3-yl, 2,5-diazabicyclo[2.2.1]heptan-2-yl, 1,6-diazaspiro[3.4]octan-6-yl, 2-oxa-5,8-diazaspiro[3.5]nonan-8-yl, and 4-azadispiro[2.1.2]octan-1-yl. 5 .3 3 ]decan-9-yl, and where available valences permit, three R b This includes compounds of formula (I) which are substituted with a substituent.

[0217] Another embodiment is where B is selected from the group consisting of pyrrolidin-1-yl, piperidin-4-yl, piperidin-1-olate-4-yl, piperazin-1-yl, 4-azaspiro[2.5]octan-7-yl, 8-azabicyclo[3.2.1]octan-3-yl, 2,5-diazabicyclo[2.2.1]heptan-2-yl, 1,6-diazaspiro[3.4]octan-6-yl, 2-oxa-5,8-diazaspiro[3.5]nonan-8-yl, and 4-azadispiro[2.1.2]octan-1-yl. 5.3 3 ]decan-9-yl, and, where available valences permit, four R b This includes compounds of formula (I) which are substituted with a substituent.

[0218] Another embodiment is where B is selected from the group consisting of pyrrolidin-1-yl, piperidin-4-yl, piperidin-1-olate-4-yl, piperazin-1-yl, 4-azaspiro[2.5]octan-7-yl, 8-azabicyclo[3.2.1]octan-3-yl, 2,5-diazabicyclo[2.2.1]heptan-2-yl, 1,6-diazaspiro[3.4]octan-6-yl, 2-oxa-5,8-diazaspiro[3.5]nonan-8-yl, and 4-azadispiro[2.1.2]octan-1-yl. 5 .3 3 ]decan-9-yl, and, where available valences permit, five R b This includes compounds of formula (I) which are substituted with a substituent.

[0219] Another embodiment is where B is heterocyclyl selected from pyrrolidin-1-yl, piperidin-4-yl, piperazin-1-yl, and 4-azaspiro[2.5]octan-7-yl, where available valences permit, 1, 2, 3, 4, or 5 R b This includes compounds of formula (I) which may be substituted with substituents.

[0220] Another embodiment includes compounds of formula (I) where B is unsubstituted heterocyclyl selected from pyrrolidin-1-yl, piperidin-4-yl, piperazin-1-yl, and 4-azaspiro[2.5]octan-7-yl.

[0221] Another embodiment is where B is heterocyclyl selected from pyrrolidin-1-yl, piperidin-4-yl, piperazin-1-yl, and 4-azaspiro[2.5]octan-7-yl, where available valences permit, one R b This includes compounds of formula (I) which are substituted with a substituent.

[0222] Another embodiment is where B is heterocyclyl selected from pyrrolidin-1-yl, piperidin-4-yl, piperazin-1-yl, and 4-azaspiro[2.5]octan-7-yl, and where available valences permit, two R b This includes compounds of formula (I) which are substituted with a substituent.

[0223] Another embodiment is where B is heterocyclyl selected from pyrrolidin-1-yl, piperidin-4-yl, piperazin-1-yl, and 4-azaspiro[2.5]octan-7-yl, and where available valences permit, three R b This includes compounds of formula (I) which are substituted with a substituent.

[0224] Another embodiment is where B is heterocyclyl selected from pyrrolidin-1-yl, piperidin-4-yl, piperazin-1-yl, and 4-azaspiro[2.5]octan-7-yl, where available valences permit, four R b This includes compounds of formula (I) which are substituted with a substituent.

[0225] Another embodiment is where B is heterocyclyl selected from pyrrolidin-1-yl, piperidin-4-yl, piperazin-1-yl, and 4-azaspiro[2.5]octan-7-yl, and where available valences permit, five R b This includes compounds of formula (I) which are substituted with a substituent.

[0226] Another embodiment is where B is pyrrolidin-1-yl and, where available valences permit, one R b This includes compounds of formula (I) which are substituted with a substituent.

[0227] Another embodiment is where B is piperidin-4-yl and, where available valences allow, 4 or 5 R b This includes compounds of formula (I) which are substituted with a substituent.

[0228] Another embodiment is where B is piperidin-4-yl and, where available valences allow, four R b This includes compounds of formula (I) which are substituted with a substituent.

[0229] Another embodiment is where B is piperidin-4-yl and, where available valences allow, five R b This includes compounds of formula (I) which are substituted with a substituent.

[0230] Another embodiment includes compounds of Formula (I) where B is unsubstituted piperazin-1-yl.

[0231] Another embodiment is where B is piperazin-1-yl and, where available valences permit, one R b This includes compounds of formula (I) which are substituted with a substituent.

[0232] Another embodiment is where B is piperazin-1-yl and, where available valences permit, two R b This includes compounds of formula (I) which are substituted with a substituent.

[0233] Another embodiment is where B is piperazin-1-yl and, where available valences allow, three R b This includes compounds of formula (I) which are substituted with a substituent.

[0234] Another embodiment is where B is piperazin-1-yl and, where available valences allow, four R b This includes compounds of formula (I) which are substituted with a substituent.

[0235] Another embodiment includes compounds of Formula (I) where B is unsubstituted 4-azaspiro[2.5]octan-7-yl.

[0236] Another embodiment is where B is 4-azaspiro[2.5]octan-7-yl and, where available valences permit, one R b This includes compounds of formula (I) which are substituted with a substituent.

[0237] Another embodiment is where B is 4-azaspiro[2.5]octan-7-yl and, where available valences permit, two R b This includes compounds of formula (I) which are substituted with a substituent.

[0238] Another embodiment includes compounds of formula (I) where B is heterocyclyl containing at least one asymmetric carbon atom having the (R) configuration.

[0239] Another embodiment includes compounds of Formula (I) where B is heterocyclyl containing at least one asymmetric carbon atom having an (S) configuration.

[0240] In one embodiment, R b But halogen, C 1-4 Alkyl, Amino, C 1-4 Alkyl-amino, (C 1-4 Alkyl) 2 -amino, and C 3-6 cycloalkyl.

[0241] Another aspect is R b But halogen, C 1-4 Alkyl, C 1-4 Alkyl-amino, and C 3-6 cycloalkyl.

[0242] Another aspect is R b is a halogen selected from bromo, chloro, fluoro, and iodo.

[0243] Another aspect is R b is fluoro.

[0244] Another aspect is R b is selected from methyl, ethyl, propyl, isopropyl, butyl, and tert-butyl; 1-4 This includes compounds of formula (I) wherein:

[0245] Another aspect is R b is selected from methyl, ethyl, and isopropyl; 1-4 This includes compounds of formula (I) wherein:

[0246] Another aspect is R b is methyl.

[0247] Another aspect is R b is ethyl.

[0248] Another aspect is R b is isopropyl.

[0249] Another aspect is R b C 1-4 Includes compounds of formula (I) which are alkyl-amino.

[0250] Another aspect is R b But, C 1-4 Alkyl-amino, C 1-4 Includes compounds of formula (I) where alkyl is selected from methyl, ethyl, propyl, isopropyl, butyl, and tert-butyl.

[0251] Another aspect is R b is selected from methylamino and tert-butylamino.

[0252] Another aspect is R b is methylamino.

[0253] Another aspect is R b is tert-butylamino.

[0254] Another aspect is R b is selected from cyclopropyl, cyclobutyl, cyclopentyl, and cyclohexyl; 3-6 Includes compounds of formula (I) which are cycloalkyl.

[0255] Another aspect is R b is cyclopropyl.

[0256] In one embodiment, R 1 Heteroaryl, heterocyclyl, phenyl, heteroaryl-C 1-4 Alkyl, Heteroaryl-C 2-4 Alkenyl, Heteroaryl-amino, and Heteroaryl-C 1-4 alkyl-amino, Heteroaryl is a 3-7 membered monocyclic or 6-10 membered bicyclic ring system having 1, 2, 3, or 4 heteroatom ring members independently selected from N, O, or S; Heterocyclyl is a saturated or partially unsaturated 3- to 7-membered monocyclic, 6- to 10-membered bicyclic or 13- to 16-membered polycyclic ring system having 1, 2 or 3 heteroatom ring members independently selected from N, O or S; Each example of phenyl, heteroaryl, or heterocyclyl may have one or two R 1a It may be substituted with a substituent.

[0257] Another aspect is R 1 Heteroaryl, heterocyclyl, phenyl, heteroaryl-C 1-4 Alkyl, Heteroaryl-C 2-4 Alkenyl, Heteroaryl-amino, and Heteroaryl-C 1-4 alkyl-amino, Heteroaryl is a 3-7 membered monocyclic or 6-10 membered bicyclic ring system having 1, 2, 3, or 4 heteroatom ring members independently selected from N, O, or S; Heterocyclyl is a saturated or partially unsaturated 3- to 7-membered monocyclic, 6- to 10-membered bicyclic or 13- to 16-membered polycyclic ring system having 1, 2 or 3 heteroatom ring members independently selected from N, O or S; Each instance of phenyl, heteroaryl or heterocyclyl is unsubstituted.

[0258] Another aspect is R 1 Heteroaryl, heterocyclyl, phenyl, heteroaryl-C 1-4 Alkyl, Heteroaryl-C 2-4 Alkenyl, Heteroaryl-amino, and Heteroaryl-C 1-4 alkyl-amino, Heteroaryl is a 3-7 membered monocyclic or 6-10 membered bicyclic ring system having 1, 2, 3, or 4 heteroatom ring members independently selected from N, O, or S; Heterocyclyl is a saturated or partially unsaturated 3- to 7-membered monocyclic, 6- to 10-membered bicyclic or 13- to 16-membered polycyclic ring system having 1, 2 or 3 heteroatom ring members independently selected from N, O or S; Each example of phenyl, heteroaryl, or heterocyclyl may be substituted with one R 1a It is substituted with a substituent.

[0259] Another aspect is R 1 Heteroaryl, heterocyclyl, phenyl, heteroaryl-C 1-4 Alkyl, Heteroaryl-C 2-4 Alkenyl, Heteroaryl-amino, and Heteroaryl-C 1-4 alkyl-amino, Heteroaryl is a 3-7 membered monocyclic or 6-10 membered bicyclic ring system having 1, 2, 3, or 4 heteroatom ring members independently selected from N, O, or S; Heterocyclyl is a saturated or partially unsaturated 3- to 7-membered monocyclic, 6- to 10-membered bicyclic or 13- to 16-membered polycyclic ring system having 1, 2 or 3 heteroatom ring members independently selected from N, O or S; Each example of phenyl, heteroaryl, or heterocyclyl may have two R1a It is substituted with a substituent.

[0260] Another aspect is R 1 Heteroaryl, Heteroaryl-C 2-4 Alkenyl, Heteroaryl-amino, and Heteroaryl-C 1-4 and alkyl-amino, heteroaryl is a 3-7 membered monocyclic or 6-10 membered bicyclic ring system having 1, 2, 3, or 4 heteroatom ring members independently selected from N, O, or S, and heteroaryl may, where available valences permit, include one or two R 1a It may be substituted with a substituent.

[0261] Another aspect is R 1 Heteroaryl, Heteroaryl-C 2-4 Alkenyl, Heteroaryl-amino, and Heteroaryl-C 1-4 alkyl-amino, Heteroaryl is a 3-7 membered monocyclic or 6-10 membered bicyclic ring system having 1, 2, 3, or 4 heteroatom ring members independently selected from N, O, or S, and heteroaryl is unsubstituted.

[0262] Another aspect is R 1 Heteroaryl, Heteroaryl-C 2-4 Alkenyl, Heteroaryl-amino, and Heteroaryl-C 1-4 alkyl-amino, Heteroaryl is a 3-7 membered monocyclic or 6-10 membered bicyclic ring system having 1, 2, 3, or 4 heteroatom ring members independently selected from N, O, or S, and heteroaryl may contain, where available valences permit, one R 1a It is substituted with a substituent.

[0263] Another aspect is R 1 Heteroaryl, Heteroaryl-C 2-4Alkenyl, Heteroaryl-amino, and Heteroaryl-C 1-4 alkyl-amino, Heteroaryl is a 3-7 membered monocyclic or 6-10 membered bicyclic ring system having 1, 2, 3, or 4 heteroatom ring members independently selected from N, O, or S, and heteroaryl may contain, where available valences permit, two R 1a It is substituted with a substituent.

[0264] Another aspect is R 1thienyl, 1H-pyrazolyl, 1H-imidazolyl, 1,3-thiazolyl, oxazolyl, 1,2,4-oxadiazolyl, 1,3,4-oxadiazolyl, 1,2,4-thiadiazolyl, 1H-1,2,3-triazolyl, 2H-1,2,3-triazolyl, 1H-1,2,4-triazolyl, 1H-tetrazolyl, 2H-tetrazolyl, pyridinyl, pyridin-2(1H)-one-yl, pyrazinyl, pyrimidinyl, pyrimidin-4(3H)-one-yl, pyridazinyl, pyridazin-3(2H)-one-yl, 1,2,4-triazinyl, 1, 3,5-Triazinyl, 1H-Indolyl, 1H-Indazolyl, 2H-Indazolyl, Indolizinyl, Benzofuranyl, Benzothienyl, 1H-Benzimidazolyl, 1,3-Benzoxazolyl, 1,3-Benzothiazolyl, 1,3-Benzodioxolyl, 1,2,3-Benzotriazolyl, 9H-Purinyl, Furo[3,2-b]pyridinyl, Furo[3,2-c]pyridinyl, Furo[2,3-c]pyridinyl, 1,3-Oxazolo[5,4-b]pyridinyl, Thieno[3,2-c]pyridinyl, Thieno[2,3-d]pyrimidinyl, 1H-Pyrrolo[ 2,3-b]pyridinyl, 1H-pyrrolo[2,3-c]pyridinyl, pyrrolo[1,2-a]pyrimidinyl, pyrrolo[1,2-a]pyrazinyl, pyrrolo[1,2-b]pyridazinyl, pyrazolo[1,5-a]pyridinyl, pyrazolo[1,5-a]pyrimidinyl, pyrazolo[1,5-a]pyrazinyl, 1H-pyrazolo[3,4-b]pyridinyl, 1H-pyrazolo[3,4-b]pyrazinyl, 1H-pyrazolo[3,4-c]pyridinyl, 1H-pyrazolo[4,3-b]pyridinyl, 1H-pyrazolo[4,3-d]pyrimidinyl, 2H-pyrazolo[4,3-b]pyridinyl Lysinyl, 2H-pyrazolo[4,3-c]pyridinyl, 5H-pyrrolo[2,3-b]pyrazinyl, imidazo[1,2-a]pyridinyl, imidazo[1,2-a]pyrazinyl, imidazo[1,2-a]pyrimidinyl, imidazo[1,2-b]pyridazinyl, imidazo[1,2-c]pyrimidinyl, 1H-imidazo[4,5-b]pyridinyl, 3H-imidazo[4,5-b]pyridinyl, imidazo[2,1-b][1,3]thiazolyl, imidazo[2,1-b][1,3,4]thiadiazolyl, [1,3]oxazolo[4,5-b]pyridinyl, [1,2,3]triazolo[1,5-a]pyridinyl, 1H-[1,2,3]triazolo[4,5-b]pyridinyl, 2H-[1,2,3]triazolo[4,5-b]pyridinyl, 3H-[1,2,3]triazolo[4,5-b]pyridinyl, [1,2,4]triazolo[1,5-a]pyridinyl, [1,2,4]triazolo[1,5-a]pyridinyl, [1,2,4]triazolo[1,5-a]pyrazinyl, [1,2,4]triazolo[4,3-a]pyridinyl, tetrazolo[1,5-a]pyridinyl, tetrazolo[1,5-b]pyridazinyl, quinolinyl, isoquinolinyl, and quinoxalinyl, where available valences permit, one or two R, 1a This includes compounds of formula (I) which may be substituted with substituents.

[0265] Another aspect is R 1thienyl, 1H-pyrazolyl, 1H-imidazolyl, 1,3-thiazolyl, oxazolyl, 1,2,4-oxadiazolyl, 1,3,4-oxadiazolyl, 1,2,4-thiadiazolyl, 1H-1,2,3-triazolyl, 2H-1,2,3-triazolyl, 1H-1,2,4-triazolyl, 1H-tetrazolyl, 2H-tetrazolyl, pyridinyl, pyridin-2(1H)-one-yl, pyrazinyl, pyrimidinyl, pyrimidin-4(3H)-one-yl, pyridazinyl, pyridazin-3(2H)-one-yl, 1,2,4-triazinyl, 1, 3,5-Triazinyl, 1H-Indolyl, 1H-Indazolyl, 2H-Indazolyl, Indolizinyl, Benzofuranyl, Benzothienyl, 1H-Benzimidazolyl, 1,3-Benzoxazolyl, 1,3-Benzothiazolyl, 1,3-Benzodioxolyl, 1,2,3-Benzotriazolyl, 9H-Purinyl, Furo[3,2-b]pyridinyl, Furo[3,2-c]pyridinyl, Furo[2,3-c]pyridinyl, 1,3-Oxazolo[5,4-b]pyridinyl, Thieno[3,2-c]pyridinyl, Thieno[2,3-d]pyrimidinyl, 1H-Pyrrolo[ 2,3-b]pyridinyl, 1H-pyrrolo[2,3-c]pyridinyl, pyrrolo[1,2-a]pyrimidinyl, pyrrolo[1,2-a]pyrazinyl, pyrrolo[1,2-b]pyridazinyl, pyrazolo[1,5-a]pyridinyl, pyrazolo[1,5-a]pyrimidinyl, pyrazolo[1,5-a]pyrazinyl, 1H-pyrazolo[3,4-b]pyridinyl, 1H-pyrazolo[3,4-b]pyrazinyl, 1H-pyrazolo[3,4-c]pyridinyl, 1H-pyrazolo[4,3-b]pyridinyl, 1H-pyrazolo[4,3-d]pyrimidinyl, 2H-pyrazolo[4,3-b]pyridinyl Lysinyl, 2H-pyrazolo[4,3-c]pyridinyl, 5H-pyrrolo[2,3-b]pyrazinyl, imidazo[1,2-a]pyridinyl, imidazo[1,2-a]pyrazinyl, imidazo[1,2-a]pyrimidinyl, imidazo[1,2-b]pyridazinyl, imidazo[1,2-c]pyrimidinyl, 1H-imidazo[4,5-b]pyridinyl, 3H-imidazo[4,5-b]pyridinyl, imidazo[2,1-b][1,3]thiazolyl, imidazo[2,1-b][1,3,4]thiadiazolyl, [1,3]oxazolo[4,5-b]pyridinyl, [1,2,3]triazolo[1,5-a]pyridinyl, 1H-[1,2,3]triazolo[4,5-b]pyridinyl, 2H-[1,2,3]triazolo[4,5-b]pyridinyl, 3H-[1,2,3]triazolo[4,5-b]pyridinyl, [1,2,4]triazolo[1,5-a]pyridinyl, [1,2,4]triazolo[1,5-a]pyridinyl, [1,2,4]triazolo[4,3-a]pyridinyl, tetrazolo[1,5-a]pyridinyl, tetrazolo[1,5-b]pyridazinyl, quinolinyl, isoquinolinyl, and quinoxalinyl.

[0266] Another aspect is R 1thienyl, 1H-pyrazolyl, 1H-imidazolyl, 1,3-thiazolyl, oxazolyl, 1,2,4-oxadiazolyl, 1,3,4-oxadiazolyl, 1,2,4-thiadiazolyl, 1H-1,2,3-triazolyl, 2H-1,2,3-triazolyl, 1H-1,2,4-triazolyl, 1H-tetrazolyl, 2H-tetrazolyl, pyridinyl, pyridin-2(1H)-one-yl, pyrazinyl, pyrimidinyl, pyrimidin-4(3H)-one-yl, pyridazinyl, pyridazin-3(2H)-one-yl, 1,2,4-triazinyl, 1, 3,5-Triazinyl, 1H-Indolyl, 1H-Indazolyl, 2H-Indazolyl, Indolizinyl, Benzofuranyl, Benzothienyl, 1H-Benzimidazolyl, 1,3-Benzoxazolyl, 1,3-Benzothiazolyl, 1,3-Benzodioxolyl, 1,2,3-Benzotriazolyl, 9H-Purinyl, Furo[3,2-b]pyridinyl, Furo[3,2-c]pyridinyl, Furo[2,3-c]pyridinyl, 1,3-Oxazolo[5,4-b]pyridinyl, Thieno[3,2-c]pyridinyl, Thieno[2,3-d]pyrimidinyl, 1H-Pyrrolo[ 2,3-b]pyridinyl, 1H-pyrrolo[2,3-c]pyridinyl, pyrrolo[1,2-a]pyrimidinyl, pyrrolo[1,2-a]pyrazinyl, pyrrolo[1,2-b]pyridazinyl, pyrazolo[1,5-a]pyridinyl, pyrazolo[1,5-a]pyrimidinyl, pyrazolo[1,5-a]pyrazinyl, 1H-pyrazolo[3,4-b]pyridinyl, 1H-pyrazolo[3,4-b]pyrazinyl, 1H-pyrazolo[3,4-c]pyridinyl, 1H-pyrazolo[4,3-b]pyridinyl, 1H-pyrazolo[4,3-d]pyrimidinyl, 2H-pyrazolo[4,3-b]pyridinyl Lysinyl, 2H-pyrazolo[4,3-c]pyridinyl, 5H-pyrrolo[2,3-b]pyrazinyl, imidazo[1,2-a]pyridinyl, imidazo[1,2-a]pyrazinyl, imidazo[1,2-a]pyrimidinyl, imidazo[1,2-b]pyridazinyl, imidazo[1,2-c]pyrimidinyl, 1H-imidazo[4,5-b]pyridinyl, 3H-imidazo[4,5-b]pyridinyl, imidazo[2,1-b][1,3]thiazolyl, imidazo[2,1-b][1,3,4]thiadiazolyl, [1,3]oxazolo[4,5-b]pyridinyl, [1,2,3]triazolo[1,5-a]pyridinyl, 1H-[1,2,3]triazolo[4,5-b]pyridinyl, 2H-[1,2,3]triazolo[4,5-b]pyridinyl, 3H-[1,2,3]triazolo[4,5-b]pyridinyl, [1,2,4]triazolo[1,5-a]pyridinyl, [1,2,4]triazolo[1,5-a]pyridinyl, [1,2,4]triazolo[1,5-a]pyridazinyl, [1,2,4]triazolo[4,3-a]pyridinyl, tetrazolo[1,5-a]pyridinyl, tetrazolo[1,5-b]pyridazinyl, quinolinyl, isoquinolinyl, and quinoxalinyl, where available valences permit, one R, 1a This includes compounds of formula (I) which are substituted with a substituent.

[0267] Another aspect is R 1thienyl, 1H-pyrazolyl, 1H-imidazolyl, 1,3-thiazolyl, oxazolyl, 1,2,4-oxadiazolyl, 1,3,4-oxadiazolyl, 1,2,4-thiadiazolyl, 1H-1,2,3-triazolyl, 2H-1,2,3-triazolyl, 1H-1,2,4-triazolyl, 1H-tetrazolyl, 2H-tetrazolyl, pyridinyl, pyridin-2(1H)-one-yl, pyrazinyl, pyrimidinyl, pyrimidin-4(3H)-one-yl, pyridazinyl, pyridazin-3(2H)-one-yl, 1,2,4-triazinyl, 1, 3,5-Triazinyl, 1H-Indolyl, 1H-Indazolyl, 2H-Indazolyl, Indolizinyl, Benzofuranyl, Benzothienyl, 1H-Benzimidazolyl, 1,3-Benzoxazolyl, 1,3-Benzothiazolyl, 1,3-Benzodioxolyl, 1,2,3-Benzotriazolyl, 9H-Purinyl, Furo[3,2-b]pyridinyl, Furo[3,2-c]pyridinyl, Furo[2,3-c]pyridinyl, 1,3-Oxazolo[5,4-b]pyridinyl, Thieno[3,2-c]pyridinyl, Thieno[2,3-d]pyrimidinyl, 1H-Pyrrolo[ 2,3-b]pyridinyl, 1H-pyrrolo[2,3-c]pyridinyl, pyrrolo[1,2-a]pyrimidinyl, pyrrolo[1,2-a]pyrazinyl, pyrrolo[1,2-b]pyridazinyl, pyrazolo[1,5-a]pyridinyl, pyrazolo[1,5-a]pyrimidinyl, pyrazolo[1,5-a]pyrazinyl, 1H-pyrazolo[3,4-b]pyridinyl, 1H-pyrazolo[3,4-b]pyrazinyl, 1H-pyrazolo[3,4-c]pyridinyl, 1H-pyrazolo[4,3-b]pyridinyl, 1H-pyrazolo[4,3-d]pyrimidinyl, 2H-pyrazolo[4,3-b]pyridinyl Lysinyl, 2H-pyrazolo[4,3-c]pyridinyl, 5H-pyrrolo[2,3-b]pyrazinyl, imidazo[1,2-a]pyridinyl, imidazo[1,2-a]pyrazinyl, imidazo[1,2-a]pyrimidinyl, imidazo[1,2-b]pyridazinyl, imidazo[1,2-c]pyrimidinyl, 1H-imidazo[4,5-b]pyridinyl, 3H-imidazo[4,5-b]pyridinyl, imidazo[2,1-b][1,3]thiazolyl, imidazo[2,1-b][1,3,4]thiadiazolyl, [1,3]oxazolo[4,5-b]pyridinyl, [1,2,3]triazolo[1,5-a]pyridinyl, 1H-[1,2,3]triazolo[4,5-b]pyridinyl, 2H-[1,2,3]triazolo[4,5-b]pyridinyl, 3H-[1,2,3]triazolo[4,5-b]pyridinyl, [1,2,4]triazolo[1,5-a]pyridinyl, [1,2,4]triazolo[1,5-a]pyridinyl, [1,2,4]triazolo[1,5-a]pyrazinyl, [1,2,4]triazolo[4,3-a]pyridinyl, tetrazolo[1,5-a]pyridinyl, tetrazolo[1,5-b]pyridazinyl, quinolinyl, isoquinolinyl, and quinoxalinyl, where available valences permit, two R, 1a This includes compounds of formula (I) which are substituted with a substituent.

[0268] Another aspect is R 1 However, 1H-pyrazolyl, 1H-imidazolyl, 1,3-thiazolyl, oxazolyl, 1H-1,2,3-triazolyl, 2H-1,2,3-triazolyl, 1H-1,2,4-triazolyl, pyridinyl, pyridin-2(1H)-one-yl, pyrimidin-4(3H)-one-yl, pyridazinyl, 1H-indazolyl, 2H-indazolyl, 1,3-benzoxazolyl, pyrrolo[1, heteroaryl selected from the group consisting of [1,2-a]pyrazinyl, imidazo[1,2-a]pyridinyl, imidazo[1,2-a]pyrazinyl, imidazo[1,2-a]pyrimidinyl, imidazo[1,2-b]pyridazinyl, [1,2,4]triazolo[1,5-a]pyridinyl, and [1,2,4]triazolo[1,5-a]pyrazinyl, where available valences permit, one or two R 1a This includes compounds of formula (I) which may be substituted with substituents.

[0269] Another aspect is R 1However, 1H-pyrazolyl, 1H-imidazolyl, 1,3-thiazolyl, oxazolyl, 1H-1,2,3-triazolyl, 2H-1,2,3-triazolyl, 1H-1,2,4-triazolyl, pyridinyl, pyridin-2(1H)-one-yl, pyrimidin-4(3H)-one-yl, pyridazinyl, 1H-indazolyl, 2H-indazolyl, 1,3-benzoxazolyl, pyridin ... and [1,2,4]triazolo[1,5-a]pyridinyl, and [1,2,4]triazolo[1,5-a]pyrazinyl.

[0270] Another aspect is R 1 However, 1H-pyrazolyl, 1H-imidazolyl, 1,3-thiazolyl, oxazolyl, 1H-1,2,3-triazolyl, 2H-1,2,3-triazolyl, 1H-1,2,4-triazolyl, pyridinyl, pyridin-2(1H)-one-yl, pyrimidin-4(3H)-one-yl, pyridazinyl, 1H-indazolyl, 2H-indazolyl, 1,3-benzoxazolyl, pyrrolo[ heteroaryl selected from [1,2-a]pyrazinyl, imidazo[1,2-a]pyridinyl, imidazo[1,2-a]pyrazinyl, imidazo[1,2-a]pyrimidinyl, imidazo[1,2-b]pyridazinyl, [1,2,4]triazolo[1,5-a]pyridinyl, and [1,2,4]triazolo[1,5-a]pyrazinyl, where available valences permit, one R 1a This includes compounds of formula (I) which are substituted with a substituent.

[0271] Another aspect is R 1However, 1H-pyrazolyl, 1H-imidazolyl, 1,3-thiazolyl, oxazolyl, 1H-1,2,3-triazolyl, 2H-1,2,3-triazolyl, 1H-1,2,4-triazolyl, pyridinyl, pyridin-2(1H)-one-yl, pyrimidin-4(3H)-one-yl, pyridazinyl, 1H-indazolyl, 2H-indazolyl, 1,3-benzoxazolyl, pyrrolo[ heteroaryl selected from [1,2-a]pyrazinyl, imidazo[1,2-a]pyridinyl, imidazo[1,2-a]pyrazinyl, imidazo[1,2-a]pyrimidinyl, imidazo[1,2-b]pyridazinyl, [1,2,4]triazolo[1,5-a]pyridinyl, and [1,2,4]triazolo[1,5-a]pyrazinyl, where available valences permit, two R 1a This includes compounds of formula (I) which are substituted with a substituent.

[0272] Another aspect is R 1Thien-2-yl, thien-3-yl, 1H-pyrazol-1-yl, 1H-pyrazol-3-yl, 1H-pyrazol-4-yl, 1H-pyrazol-5-yl, 1H-imidazol-1-yl, 1H-imidazol-4-yl, 1,3-thiazol-2-yl, 1,3-thiazol-5-yl, 1,3-oxazol-2-yl, 1,3-oxazol-4-yl, 1,3-oxazol-5-yl, 1,2,4-oxadiazol-3-yl, 1,3,4-oxadiazol-2-yl, 1,2,4-thiadiazol-5-yl, 1H-1, 2,3-Triazol-1-yl, 1H-1,2,3-triazol-4-yl, 1H-1,2,3-triazol-5-yl, 2H-1,2,3-triazol-2-yl, 2H-1,2,3-triazol-4-yl, 1H-1,2,4-triazol-1-yl, 1H-1,2,4-triazol-3-yl, 1H-1,2,4-triazol-5-yl, 1H-tetrazol-1-yl, 1H-tetrazol-5-yl, 2H-tetrazol-2-yl, 2H-tetrazol-5-yl, pyridin-2-yl, pyridin-3-yl, pyridin- 4-yl, pyridin-2(1H)-one-4-yl, pyridin-2(1H)-one-5-yl, pyridin-2(1H)-one-6-yl, pyrazin-2-yl, pyrazin-3-yl, pyrimidin-2-yl, pyrimidin-4-yl, pyrimidin-5-yl, pyrimidin-4(3H)-one-6-yl, pyridazin-3-yl, pyridazin-4-yl, pyridazin-3(2H)-one-5-yl, 1,2,4-triazin-3-yl, 1,3,5-triazin-2-yl, 1H-indol-3-yl, 1H-indol-4-yl, 1H-indol- 5-yl, 1H-indol-6-yl, 1H-indazol-5-yl, 1H-indazol-6-yl, 2H-indazol-4-yl, 2H-indazol-5-yl, 2H-indazol-6-yl, indolizin-2-yl, benzofuran-2-yl, benzofuran-5-yl, benzothien-2-yl, benzothien-3-yl, 1H-benzimidazol-2-yl, 1H-benzimidazol-5-yl, 1H-benzimidazol-6-yl, 1,3-benzoxazol-2-yl, 1,3-benzoxazol-5-yl, 1,3-Benzoxazol-6-yl, 1,3-benzothiazol-2-yl, 1,3-benzothiazol-5-yl, 1,3-benzothiazol-6-yl, 1,3-benzodioxol-5-yl, 1,2,3-benzotriazol-5-yl, 9H-purin-8-yl, furo[3,2-b]pyridin-2-yl, furo[3,2-c]pyridin-2-yl, furo[2,3-c]pyridin-2-yl, 1,3-oxazolo[5,4-b]pyridin-5-yl, thieno[3,2-c]pyridin-2-yl, thieno[2,3-d]pyrimidin-6-yl pyrrolo[2,3-b]pyridin-5-yl, 1H-pyrrolo[2,3-c]pyridin-4-yl, pyrrolo[1,2-a]pyrimidin-7-yl, pyrrolo[1,2-a]pyrazin-7-yl, pyrrolo[1,2-b]pyridazin-2-yl, pyrazolo[1,5-a]pyridin-2-yl, pyrazolo[1,5-a]pyridin-5-yl, pyrazolo[1,5-a]pyrazin-2-yl, pyrazolo[1,5-a]pyrimidin-2-yl, pyrazolo[1,5-a]pyrimidin-5-yl, 1H-pyrazolo[3,4-b]pyraz ... 1H-pyrazolo[3,4-b]pyridin-5-yl, 1H-pyrazolo[3,4-b]pyridin-6-yl, 1H-pyrazolo[3,4-c]pyridin-1-yl, 1H-pyrazolo[3,4-c]pyridin-5-yl, 1H-pyrazolo[4,3-b]pyridin-5-yl, 1H-pyrazolo[4,3-b]pyridin-6-yl, 1H-pyrazolo[4,3-d]pyrimidin-5-yl, 2H-pyrazolo[4,3-b]pyridin-5-yl, 2H-pyrazolo[4,3-c]pyridin-5-yl, 5H-pyrrolo[2,3-b]pyrazin-2-yl, imidazo[1,2-a ]pyridin-2-yl, imidazo[1,2-a]pyridin-6-yl, imidazo[1,2-a]pyrazin-2-yl, imidazo[1,2-a]pyrazin-6-yl, imidazo[1,2-a]pyrimidin-2-yl, imidazo[1,2-a]pyrimidin-6-yl, imidazo[1,2-b]pyridazin-2-yl, imidazo[1,2-b]pyridazin-6-yl, imidazo[1,2-c]pyrimidin-2-yl, 1H-imidazo[4,5-b]pyridin-5-yl, 3H-imidazo[4,5-b]pyridin-5-yl, imidazo[2,1-b][1,3]thiazol-6-yl, imidazo[2,1-b][1,3,4]thiadiazol-6-yl, [1,3]oxazolo[4,5-b]pyridin-2-yl, [1,2,3]triazolo[1,5-a]pyridin-5-yl, [1,2,3]triazolo[1,5-a]pyridin-6-yl, 1H-[1,2,3]triazolo[4,5-b]pyridin-5-yl, 2H-[1,2,3]triazolo[4,5-b]pyridin-6-yl, 3H-[1,2,3]triazolo[4,5-b]pyridin-5-yl, [1,2,4]triazolo[1,5-a]pyridin-2-yl, [1,2,4]triazolo[1,5-a]pyridin-6-yl, [1,2,4]thiazolo[1,5-a]pyridin-6-yl heteroaryl selected from riazolo[1,5-a]pyridin-7-yl, [1,2,4]triazolo[1,5-a]pyrazin-2-yl, [1,2,4]triazolo[1,5-a]pyrazin-5-yl, [1,2,4]triazolo[1,5-a]pyrazin-6-yl, [1,2,4]triazolo[4,3-a]pyridin-6-yl, [1,2,4]triazolo[4,3-a]pyridin-7-yl, tetrazolo[1,5-a]pyridin-7-yl, tetrazolo[1,5-b]pyridazin-7-yl, quinolin-6-yl, isoquinolin-6-yl, and quinoxalin-2-yl, where available valences permit, one or two R, 1a This includes compounds of formula (I) which may be substituted with substituents.

[0273] Another aspect is R 1Thien-2-yl, thien-3-yl, 1H-pyrazol-1-yl, 1H-pyrazol-3-yl, 1H-pyrazol-4-yl, 1H-pyrazol-5-yl, 1H-imidazol-1-yl, 1H-imidazol-4-yl, 1,3-thiazol-2-yl, 1,3-thiazol-5-yl, 1,3-oxazol-2-yl, 1,3-oxazol-4-yl, 1,3-oxazol-5-yl, 1,2,4-oxadiazol-3-yl, 1,3,4-oxadiazol-2-yl, 1,2,4-thiadiazol-5-yl, 1H-1, 2,3-Triazol-1-yl, 1H-1,2,3-triazol-4-yl, 1H-1,2,3-triazol-5-yl, 2H-1,2,3-triazol-2-yl, 2H-1,2,3-triazol-4-yl, 1H-1,2,4-triazol-1-yl, 1H-1,2,4-triazol-3-yl, 1H-1,2,4-triazol-5-yl, 1H-tetrazol-1-yl, 1H-tetrazol-5-yl, 2H-tetrazol-2-yl, 2H-tetrazol-5-yl, pyridin-2-yl, pyridin-3-yl, pyridin- 4-yl, pyridin-2(1H)-one-4-yl, pyridin-2(1H)-one-5-yl, pyridin-2(1H)-one-6-yl, pyrazin-2-yl, pyrazin-3-yl, pyrimidin-2-yl, pyrimidin-4-yl, pyrimidin-5-yl, pyrimidin-4(3H)-one-6-yl, pyridazin-3-yl, pyridazin-4-yl, pyridazin-3(2H)-one-5-yl, 1,2,4-triazin-3-yl, 1,3,5-triazin-2-yl, 1H-indol-3-yl, 1H-indol-4-yl, 1H-indol- 5-yl, 1H-indol-6-yl, 1H-indazol-5-yl, 1H-indazol-6-yl, 2H-indazol-4-yl, 2H-indazol-5-yl, 2H-indazol-6-yl, indolizin-2-yl, benzofuran-2-yl, benzofuran-5-yl, benzothien-2-yl, benzothien-3-yl, 1H-benzimidazol-2-yl, 1H-benzimidazol-5-yl, 1H-benzimidazol-6-yl, 1,3-benzoxazol-2-yl, 1,3-benzoxazol-5-yl, 1,3-Benzoxazol-6-yl, 1,3-benzothiazol-2-yl, 1,3-benzothiazol-5-yl, 1,3-benzothiazol-6-yl, 1,3-benzodioxol-5-yl, 1,2,3-benzotriazol-5-yl, 9H-purin-8-yl, furo[3,2-b]pyridin-2-yl, furo[3,2-c]pyridin-2-yl, furo[2,3-c]pyridin-2-yl, 1,3-oxazolo[5,4-b]pyridin-5-yl, thieno[3,2-c]pyridin-2-yl, thieno[2,3-d]pyrimidin-6-yl pyrrolo[2,3-b]pyridin-5-yl, 1H-pyrrolo[2,3-c]pyridin-4-yl, pyrrolo[1,2-a]pyrimidin-7-yl, pyrrolo[1,2-a]pyrazin-7-yl, pyrrolo[1,2-b]pyridazin-2-yl, pyrazolo[1,5-a]pyridin-2-yl, pyrazolo[1,5-a]pyridin-5-yl, pyrazolo[1,5-a]pyrazin-2-yl, pyrazolo[1,5-a]pyrimidin-2-yl, pyrazolo[1,5-a]pyrimidin-5-yl, 1H-pyrazolo[3,4-b]pyraz ... 1H-pyrazolo[3,4-b]pyridin-5-yl, 1H-pyrazolo[3,4-b]pyridin-6-yl, 1H-pyrazolo[3,4-c]pyridin-1-yl, 1H-pyrazolo[3,4-c]pyridin-5-yl, 1H-pyrazolo[4,3-b]pyridin-5-yl, 1H-pyrazolo[4,3-b]pyridin-6-yl, 1H-pyrazolo[4,3-d]pyrimidin-5-yl, 2H-pyrazolo[4,3-b]pyridin-5-yl, 2H-pyrazolo[4,3-c]pyridin-5-yl, 5H-pyrrolo[2,3-b]pyrazin-2-yl, imidazo[1,2-a ]pyridin-2-yl, imidazo[1,2-a]pyridin-6-yl, imidazo[1,2-a]pyrazin-2-yl, imidazo[1,2-a]pyrazin-6-yl, imidazo[1,2-a]pyrimidin-2-yl, imidazo[1,2-a]pyrimidin-6-yl, imidazo[1,2-b]pyridazin-2-yl, imidazo[1,2-b]pyridazin-6-yl, imidazo[1,2-c]pyrimidin-2-yl, 1H-imidazo[4,5-b]pyridin-5-yl, 3H-imidazo[4,5-b]pyridin-5-yl, imidazo[2,1-b][1,3]thiazol-6-yl, imidazo[2,1-b][1,3,4]thiadiazol-6-yl, [1,3]oxazolo[4,5-b]pyridin-2-yl, [1,2,3]triazolo[1,5-a]pyridin-5-yl, [1,2,3]triazolo[1,5-a]pyridin-6-yl, 1H-[1,2,3]triazolo[4,5-b]pyridin-5-yl, 2H-[1,2,3]triazolo[4,5-b]pyridin-6-yl, 3H-[1,2,3]triazolo[4,5-b]pyridin-5-yl, [1,2,4]triazolo[1,5-a]pyridin-2-yl, [1,2,4]triazolo[1,5-a]pyridin-6-yl, [1 [1,2,4]triazolo[1,5-a]pyridin-7-yl, [1,2,4]triazolo[1,5-a]pyrazin-2-yl, [1,2,4]triazolo[1,5-a]pyrazin-5-yl, [1,2,4]triazolo[1,5-a]pyrazin-6-yl, [1,2,4]triazolo[4,3-a]pyridin-6-yl, [1,2,4]triazolo[4,3-a]pyridin-7-yl, tetrazolo[1,5-a]pyridin-7-yl, tetrazolo[1,5-b]pyridazin-7-yl, quinolin-6-yl, isoquinolin-6-yl, and quinoxalin-2-yl.

[0274] Another aspect is R 1Thien-2-yl, thien-3-yl, 1H-pyrazol-1-yl, 1H-pyrazol-3-yl, 1H-pyrazol-4-yl, 1H-pyrazol-5-yl, 1H-imidazol-1-yl, 1H-imidazol-4-yl, 1,3-thiazol-2-yl, 1,3-thiazol-5-yl, 1,3-oxazol-2-yl, 1,3-oxazol-4-yl, 1,3-oxazol-5-yl, 1,2,4-oxadiazol-3-yl, 1,3,4-oxadiazol-2-yl, 1,2,4-thiadiazol-5-yl, 1H-1, 2,3-Triazol-1-yl, 1H-1,2,3-triazol-4-yl, 1H-1,2,3-triazol-5-yl, 2H-1,2,3-triazol-2-yl, 2H-1,2,3-triazol-4-yl, 1H-1,2,4-triazol-1-yl, 1H-1,2,4-triazol-3-yl, 1H-1,2,4-triazol-5-yl, 1H-tetrazol-1-yl, 1H-tetrazol-5-yl, 2H-tetrazol-2-yl, 2H-tetrazol-5-yl, pyridin-2-yl, pyridin-3-yl, pyridin- 4-yl, pyridin-2(1H)-one-4-yl, pyridin-2(1H)-one-5-yl, pyridin-2(1H)-one-6-yl, pyrazin-2-yl, pyrazin-3-yl, pyrimidin-2-yl, pyrimidin-4-yl, pyrimidin-5-yl, pyrimidin-4(3H)-one-6-yl, pyridazin-3-yl, pyridazin-4-yl, pyridazin-3(2H)-one-5-yl, 1,2,4-triazin-3-yl, 1,3,5-triazin-2-yl, 1H-indol-3-yl, 1H-indol-4-yl, 1H-indol- 5-yl, 1H-indol-6-yl, 1H-indazol-5-yl, 1H-indazol-6-yl, 2H-indazol-4-yl, 2H-indazol-5-yl, 2H-indazol-6-yl, indolizin-2-yl, benzofuran-2-yl, benzofuran-5-yl, benzothien-2-yl, benzothien-3-yl, 1H-benzimidazol-2-yl, 1H-benzimidazol-5-yl, 1H-benzimidazol-6-yl, 1,3-benzoxazol-2-yl, 1,3-benzoxazol-5-yl, 1,3-Benzoxazol-6-yl, 1,3-benzothiazol-2-yl, 1,3-benzothiazol-5-yl, 1,3-benzothiazol-6-yl, 1,3-benzodioxol-5-yl, 1,2,3-benzotriazol-5-yl, 9H-purin-8-yl, furo[3,2-b]pyridin-2-yl, furo[3,2-c]pyridin-2-yl, furo[2,3-c]pyridin-2-yl, 1,3-oxazolo[5,4-b]pyridin-5-yl, thieno[3,2-c]pyridin-2-yl, thieno[2,3-d]pyrimidin-6-yl pyrrolo[2,3-b]pyridin-5-yl, 1H-pyrrolo[2,3-c]pyridin-4-yl, pyrrolo[1,2-a]pyrimidin-7-yl, pyrrolo[1,2-a]pyrazin-7-yl, pyrrolo[1,2-b]pyridazin-2-yl, pyrazolo[1,5-a]pyridin-2-yl, pyrazolo[1,5-a]pyridin-5-yl, pyrazolo[1,5-a]pyrazin-2-yl, pyrazolo[1,5-a]pyrimidin-2-yl, pyrazolo[1,5-a]pyrimidin-5-yl, 1H-pyrazolo[3,4-b]pyraz ... 1H-pyrazolo[3,4-b]pyridin-5-yl, 1H-pyrazolo[3,4-b]pyridin-6-yl, 1H-pyrazolo[3,4-c]pyridin-1-yl, 1H-pyrazolo[3,4-c]pyridin-5-yl, 1H-pyrazolo[4,3-b]pyridin-5-yl, 1H-pyrazolo[4,3-b]pyridin-6-yl, 1H-pyrazolo[4,3-d]pyrimidin-5-yl, 2H-pyrazolo[4,3-b]pyridin-5-yl, 2H-pyrazolo[4,3-c]pyridin-5-yl, 5H-pyrrolo[2,3-b]pyrazin-2-yl, imidazo[1,2-a ]pyridin-2-yl, imidazo[1,2-a]pyridin-6-yl, imidazo[1,2-a]pyrazin-2-yl, imidazo[1,2-a]pyrazin-6-yl, imidazo[1,2-a]pyrimidin-2-yl, imidazo[1,2-a]pyrimidin-6-yl, imidazo[1,2-b]pyridazin-2-yl, imidazo[1,2-b]pyridazin-6-yl, imidazo[1,2-c]pyrimidin-2-yl, 1H-imidazo[4,5-b]pyridin-5-yl, 3H-imidazo[4,5-b]pyridin-5-yl, imidazo[2,1-b][1,3]thiazol-6-yl, imidazo[2,1-b][1,3,4]thiadiazol-6-yl, [1,3]oxazolo[4,5-b]pyridin-2-yl, [1,2,3]triazolo[1,5-a]pyridin-5-yl, [1,2,3]triazolo[1,5-a]pyridin-6-yl, 1H-[1,2,3]triazolo[4,5-b]pyridin-5-yl, 2H-[1,2,3]triazolo[4,5-b]pyridin-6-yl, 3H-[1,2,3]triazolo[4,5-b]pyridin-5-yl, [1,2,4]triazolo[1,5-a]pyridin-2-yl, [1,2,4]triazolo[1,5-a]pyridin-6-yl, [1,2,4 ]triazolo[1,5-a]pyridin-7-yl, [1,2,4]triazolo[1,5-a]pyrazin-2-yl, [1,2,4]triazolo[1,5-a]pyrazin-5-yl, [1,2,4]triazolo[1,5-a]pyrazin-6-yl, [1,2,4]triazolo[4,3-a]pyridin-6-yl, [1,2,4]triazolo[4,3-a]pyridin-7-yl, tetrazolo[1,5-a]pyridin-7-yl, tetrazolo[1,5-b]pyridazin-7-yl, quinolin-6-yl, isoquinolin-6-yl, and quinoxalin-2-yl, where available valences permit, one R, 1a This includes compounds of formula (I) which are substituted with a substituent.

[0275] Another aspect is R 1Thien-2-yl, thien-3-yl, 1H-pyrazol-1-yl, 1H-pyrazol-3-yl, 1H-pyrazol-4-yl, 1H-pyrazol-5-yl, 1H-imidazol-1-yl, 1H-imidazol-4-yl, 1,3-thiazol-2-yl, 1,3-thiazol-5-yl, 1,3-oxazol-2-yl, 1,3-oxazol-4-yl, 1,3-oxazol-5-yl, 1,2,4-oxadiazol-3-yl, 1,3,4-oxadiazol-2-yl, 1,2,4-thiadiazol-5-yl, 1H-1, 2,3-Triazol-1-yl, 1H-1,2,3-triazol-4-yl, 1H-1,2,3-triazol-5-yl, 2H-1,2,3-triazol-2-yl, 2H-1,2,3-triazol-4-yl, 1H-1,2,4-triazol-1-yl, 1H-1,2,4-triazol-3-yl, 1H-1,2,4-triazol-5-yl, 1H-tetrazol-1-yl, 1H-tetrazol-5-yl, 2H-tetrazol-2-yl, 2H-tetrazol-5-yl, pyridin-2-yl, pyridin-3-yl, pyridin- 4-yl, pyridin-2(1H)-one-4-yl, pyridin-2(1H)-one-5-yl, pyridin-2(1H)-one-6-yl, pyrazin-2-yl, pyrazin-3-yl, pyrimidin-2-yl, pyrimidin-4-yl, pyrimidin-5-yl, pyrimidin-4(3H)-one-6-yl, pyridazin-3-yl, pyridazin-4-yl, pyridazin-3(2H)-one-5-yl, 1,2,4-triazin-3-yl, 1,3,5-triazin-2-yl, 1H-indol-3-yl, 1H-indol-4-yl, 1H-indol- 5-yl, 1H-indol-6-yl, 1H-indazol-5-yl, 1H-indazol-6-yl, 2H-indazol-4-yl, 2H-indazol-5-yl, 2H-indazol-6-yl, indolizin-2-yl, benzofuran-2-yl, benzofuran-5-yl, benzothien-2-yl, benzothien-3-yl, 1H-benzimidazol-2-yl, 1H-benzimidazol-5-yl, 1H-benzimidazol-6-yl, 1,3-benzoxazol-2-yl, 1,3-benzoxazol-5-yl, 1,3-Benzoxazol-6-yl, 1,3-benzothiazol-2-yl, 1,3-benzothiazol-5-yl, 1,3-benzothiazol-6-yl, 1,3-benzodioxol-5-yl, 1,2,3-benzotriazol-5-yl, 9H-purin-8-yl, furo[3,2-b]pyridin-2-yl, furo[3,2-c]pyridin-2-yl, furo[2,3-c]pyridin-2-yl, 1,3-oxazolo[5,4-b]pyridin-5-yl, thieno[3,2-c]pyridin-2-yl, thieno[2,3-d]pyrimidin-6-yl pyrrolo[2,3-b]pyridin-5-yl, 1H-pyrrolo[2,3-c]pyridin-4-yl, pyrrolo[1,2-a]pyrimidin-7-yl, pyrrolo[1,2-a]pyrazin-7-yl, pyrrolo[1,2-b]pyridazin-2-yl, pyrazolo[1,5-a]pyridin-2-yl, pyrazolo[1,5-a]pyridin-5-yl, pyrazolo[1,5-a]pyrazin-2-yl, pyrazolo[1,5-a]pyrimidin-2-yl, pyrazolo[1,5-a]pyrimidin-5-yl, 1H-pyrazolo[3,4-b]pyraz ... 1H-pyrazolo[3,4-b]pyridin-5-yl, 1H-pyrazolo[3,4-b]pyridin-6-yl, 1H-pyrazolo[3,4-c]pyridin-1-yl, 1H-pyrazolo[3,4-c]pyridin-5-yl, 1H-pyrazolo[4,3-b]pyridin-5-yl, 1H-pyrazolo[4,3-b]pyridin-6-yl, 1H-pyrazolo[4,3-d]pyrimidin-5-yl, 2H-pyrazolo[4,3-b]pyridin-5-yl, 2H-pyrazolo[4,3-c]pyridin-5-yl, 5H-pyrrolo[2,3-b]pyrazin-2-yl, imidazo[1,2-a ]pyridin-2-yl, imidazo[1,2-a]pyridin-6-yl, imidazo[1,2-a]pyrazin-2-yl, imidazo[1,2-a]pyrazin-6-yl, imidazo[1,2-a]pyrimidin-2-yl, imidazo[1,2-a]pyrimidin-6-yl, imidazo[1,2-b]pyridazin-2-yl, imidazo[1,2-b]pyridazin-6-yl, imidazo[1,2-c]pyrimidin-2-yl, 1H-imidazo[4,5-b]pyridin-5-yl, 3H-imidazo[4,5-b]pyridin-5-yl, imidazo[2,1-b][1,3]thiazol-6-yl, imidazo[2,1-b][1,3,4]thiadiazol-6-yl, [1,3]oxazolo[4,5-b]pyridin-2-yl, [1,2,3]triazolo[1,5-a]pyridin-5-yl, [1,2,3]triazolo[1,5-a]pyridin-6-yl, 1H-[1,2,3]triazolo[4,5-b]pyridin-5-yl, 2H-[1,2,3]triazolo[4,5-b]pyridin-6-yl, 3H-[1,2,3]triazolo[4,5-b]pyridin-5-yl, [1,2,4]triazolo[1,5-a]pyridin-2-yl, [1,2,4]triazolo[1,5-a]pyridin-6-yl, [1,2,4 ]triazolo[1,5-a]pyridin-7-yl, [1,2,4]triazolo[1,5-a]pyrazin-2-yl, [1,2,4]triazolo[1,5-a]pyrazin-5-yl, [1,2,4]triazolo[1,5-a]pyrazin-6-yl, [1,2,4]triazolo[4,3-a]pyridin-6-yl, [1,2,4]triazolo[4,3-a]pyridin-7-yl, tetrazolo[1,5-a]pyridin-7-yl, tetrazolo[1,5-b]pyridazin-7-yl, quinolin-6-yl, isoquinolin-6-yl, and quinoxalin-2-yl, where available valences permit, two R, 1a This includes compounds of formula (I) which are substituted with a substituent.

[0276] Another aspect is R 11H-pyrazol-3-yl, 1H-pyrazol-4-yl, 1H-imidazol-1-yl, 1,3-thiazol-2-yl, 1,3-oxazol-2-yl, 1,3-oxazol-5-yl, 1H-1,2,3-triazol-1-yl, 2H-1,2,3-triazol-2-yl, 1H-1,2,4-triazol-1-yl, pyridin-4-yl, pyridin-2(1H)-one-4-yl, pyrimidin-4(3H)-one-6-yl, pyridazin-3-yl, 1H-indazol-5-yl, 2H-indazol-4-yl , 2H-indazol-5-yl, 1,3-benzoxazol-6-yl, pyrrolo[1,2-a]pyrazin-7-yl, imidazo[1,2-a]pyridin-6-yl, imidazo[1,2-a]pyrazin-6-yl, imidazo[1,2-a]pyrimidin-6-yl, imidazo[1,2-b]pyridazin-6-yl, [1,2,4]triazolo[1,5-a]pyridin-6-yl, and [1,2,4]triazolo[1,5-a]pyrazin-2-yl, where available valences permit, one or two R 1a This includes compounds of formula (I) which may be substituted with substituents.

[0277] Another aspect is R 1However, 1H-pyrazol-3-yl, 1H-pyrazol-4-yl, 1H-imidazol-1-yl, 1,3-thiazol-2-yl, 1,3-oxazol-2-yl, 1,3-oxazol-5-yl, 1H-1,2,3-triazol-1-yl, 2H-1,2,3-triazol-2-yl, 1H-1,2,4-triazol-1-yl, pyridin-4-yl, pyridin-2(1H)-one-4-yl, pyrimidin-4(3H)-one-6-yl, pyridazin-3-yl, 1H-indazol-5-yl, 2H-indazole and [1,2,4]triazolo[1,5-a]pyridin-6-yl.

[0278] Another aspect is R 1However, 1H-pyrazol-3-yl, 1H-pyrazol-4-yl, 1H-imidazol-1-yl, 1,3-thiazol-2-yl, 1,3-oxazol-2-yl, 1,3-oxazol-5-yl, 1H-1,2,3-triazol-1-yl, 2H-1,2,3-triazol-2-yl, 1H-1,2,4-triazol-1-yl, pyridin-4-yl, pyridin-2(1H)-one-4-yl, pyrimidin-4(3H)-one-6-yl, pyridazin-3-yl, 1H-indazol-5-yl, 2H-indazol-4-yl heteroaryl selected from among R, 2H-indazol-5-yl, 1,3-benzoxazol-6-yl, pyrrolo[1,2-a]pyrazin-7-yl, imidazo[1,2-a]pyridin-6-yl, imidazo[1,2-a]pyrazin-6-yl, imidazo[1,2-a]pyrimidin-6-yl, imidazo[1,2-b]pyridazin-6-yl, [1,2,4]triazolo[[1,5-a]pyridin-6-yl, and [1,2,4]triazolo[[1,5-a]pyrazin-2-yl, where available valences permit, one R 1a This includes compounds of formula (I) which are substituted with a substituent.

[0279] Another aspect is R 1However, 1H-pyrazol-3-yl, 1H-pyrazol-4-yl, 1H-imidazol-1-yl, 1,3-thiazol-2-yl, 1,3-oxazol-2-yl, 1,3-oxazol-5-yl, 1H-1,2,3-triazol-1-yl, 2H-1,2,3-triazol-2-yl, 1H-1,2,4-triazol-1-yl, pyridin-4-yl, pyridin-2(1H)-one-4-yl, pyrimidin-4(3H)-one-6-yl, pyridazin-3-yl, 1H-indazol-5-yl, 2H-indazol-4-yl heteroaryl selected from among pyrrolo[1,2-a]pyrazin-7-yl, imidazo[1,2-a]pyridin-6-yl, imidazo[1,2-a]pyrazin-6-yl, imidazo[1,2-a]pyrimidin-6-yl, imidazo[1,2-b]pyridazin-6-yl, [1,2,4]triazolo[1,5-a]pyridin-6-yl, and [1,2,4]triazolo[1,5-a]pyrazin-2-yl, where available valences permit, two R 1a This includes compounds of formula (I) which are substituted with a substituent.

[0280] Another aspect is R 1 Heteroaryl-C 2-4 alkenyl, Heteroaryl is a 3-7 membered monocyclic or 6-10 membered bicyclic ring system having 1, 2, 3, or 4 heteroatom ring members independently selected from N, O, or S, and heteroaryl may contain, where available valences permit, one or two R 1a It may be substituted with a substituent.

[0281] Another aspect is R 1 Heteroaryl-C 2-4 alkenyl, heteroaryl is selected from thienyl, 1H-pyrazolyl, 1H-imidazolyl, 1,3-thiazolyl, oxazolyl, 1,2,4-oxadiazolyl, 1,3,4-oxadiazolyl, 1,2,4-thiadiazolyl, 1H-tetrazolyl, 2H-tetrazolyl, pyridinyl, pyrazinyl, pyrimidinyl, 1,2,4-triazinyl, 1,3,5-triazinyl, 1H-indolyl, 1H-indazolyl, 2H-indazolyl, indolizinyl, benzofuranyl, benzothienyl, 1H-benzimidazolyl, 1,3-benzoxazolyl, 1,3-benzothiazolyl, 1,3-benzodioxolyl, 1,2,3-benzotriazolyl, 9H-purinyl, quinolinyl, isoquinolinyl, and quinoxalinyl; C 2-4 alkenyl is selected from ethenyl, propenyl, and butenyl; Heteroaryl may contain one or two R, where available valences permit. 1a It may be substituted with a substituent.

[0282] Another aspect is R 1 is 2-(1H-pyrazol-4-yl)ethenyl and, if permitted by available valences, one or two R 1a This includes compounds of formula (I) which may be substituted with substituents.

[0283] Another aspect is R 1is heteroaryl-amino, and heteroaryl is thienyl, 1H-pyrazolyl, 1H-imidazolyl, 1,3-thiazolyl, oxazolyl, 1,2,4-oxadiazolyl, 1,3,4-oxadiazolyl, 1,2,4-thiadiazolyl, 1H-tetrazolyl, 2H-tetrazolyl, pyridinyl, pyrazinyl, pyrimidinyl, pyridazinyl, 1,2,4-triazinyl, 1,3,5-triazinyl, 1H - selected from indolyl, 1H-indazolyl, 2H-indazolyl, indolizinyl, benzofuranyl, benzothienyl, 1H-benzimidazolyl, 1,3-benzoxazolyl, 1,3-benzothiazolyl, 1,3-benzodioxolyl, 1,2,3-benzotriazolyl, 9H-purinyl, quinolinyl, isoquinolinyl, and quinoxalinyl, where available valences permit, one or two R 1a This includes compounds of formula (I) which may be substituted with substituents.

[0284] Another aspect is R 1 are (pyridin-3-yl)amino, (pyrazin-2-yl)amino, and (pyrimidin-5-yl)amino, and, where available valences permit, one or two R 1a This includes compounds of formula (I) which may be substituted with substituents.

[0285] Another aspect is R 1 Heteroaryl-C 1-4Includes compounds of formula (I) that are alkyl-amino, heteroaryl is thienyl, 1H-pyrazolyl, 1H-imidazolyl, 1,3-thiazolyl, oxazolyl, 1,2,4-oxadiazolyl, 1,3,4-oxadiazolyl, 1,2,4-thiadiazolyl, 1H-tetrazolyl, 2H-tetrazolyl, pyridinyl, pyrazinyl, pyrimidinyl, pyridazinyl, 1,2,4-triazinyl. , 1,3,5-triazinyl, 1H-indolyl, 1H-indazolyl, 2H-indazolyl, indolizinyl, benzofuranyl, benzothienyl, 1H-benzimidazolyl, 1,3-benzoxazolyl, 1,3-benzothiazolyl, 1,3-benzodioxolyl, 1,2,3-benzotriazolyl, 9H-purinyl, quinolinyl, isoquinolinyl, and quinoxalinyl; C 1-4 alkyl is selected from methyl, ethyl, propyl, and butyl; Heteroaryl may contain one or two R, where available valences permit. 1a It may be substituted with a substituent.

[0286] Another aspect is R 1 is (1H-pyrazol-4-yl)methylamino, (pyridin-3-yl)methylamino, (pyridin-4-yl)methylamino, (quinolin-3-yl)methylamino, and (quinolin-8-yl)methylamino, where available valences permit, one or two R 1a This includes compounds of formula (I) which may be substituted with substituents.

[0287] In one embodiment, R 1a But halogen, hydroxyl, cyano, C 1-4 Alkyl, Deuterium-C 1-4 Alkyl, halo-C 1-4 Alkyl, Amino, C 1-4 Alkyl-amino, (C 1-4 Alkyl) 2 - Amino, C 1-4 Alkoxy, Deuterium-C 1-4 Alkoxy, and halo-C 1-4The compounds of formula (I) include those compounds in which:

[0288] Another aspect is R 1a But halogen, cyano, C 1-4 Alkyl, Deuterium-C 1-4 Alkyl, halo-C 1-4 Alkyl, C 1-4 Alkoxy, and Deuterium-C 1-4 The compounds of formula (I) include those compounds in which:

[0289] Another aspect is R 1a is selected from methyl, ethyl, propyl, isopropyl, butyl, and tert-butyl; 1-4 This includes compounds of formula (I) wherein:

[0290] Another aspect is R 1a is selected from methyl and ethyl.

[0291] Another aspect is R 1a is methyl.

[0292] Another aspect is R 1a is ethyl.

[0293] Another aspect is R 1a is a halogen selected from bromo, chloro, fluoro, and iodo.

[0294] Another aspect is R 1a is fluoro.

[0295] Another aspect is R 1a is cyano.

[0296] Another aspect is R 1a But deuterium C 1-4 Alkyl, C 1-4Alkyl includes compounds of formula (I) selected from methyl, ethyl, propyl, isopropyl, butyl, and tert-butyl, which are partially or fully substituted with one or more deuterium atoms, where available valences permit.

[0297] Another aspect is R 1a but( 2 H 3 ) methyl.

[0298] Another aspect is R 1a But, Halo-C 1-4 Alkyl, C 1-4 Alkyl includes compounds of formula (I) where available valences permit, selected from methyl, ethyl, propyl, isopropyl, butyl, and tert-butyl, partially or fully substituted with one or more halogen atoms.

[0299] Another aspect is R 1a is trifluoromethyl.

[0300] Another aspect is R 1a is selected from methoxy, ethoxy, propoxy, isopropoxy, butoxy and tert-butoxy; 1-4 Includes compounds of formula (I) which are alkoxy.

[0301] Another aspect is R 1a is methoxy.

[0302] Another aspect is R 1a But deuterium C 1-4 Alkoxy, C 1-4 Alkoxy includes compounds of formula (I) selected from methoxy, ethoxy, propoxy, isopropoxy, butoxy and tert-butoxy, partially or fully substituted with one or more deuterium atoms, where available valences permit.

[0303] Another aspect is R1a but( 2 H 3 ) methoxy.

[0304] Another aspect of the present invention includes a compound of formula (II), or a form thereof: [ka] (In the formula, X is O, NR x , or a bond, R x is hydrogen and C 1-4 alkyl, B is heterocyclyl; Heterocyclyl is a saturated or partially unsaturated 3- to 7-membered monocyclic, 6- to 10-membered bicyclic, or 13- to 16-membered polycyclic ring system having 1, 2, or 3 heteroatom ring members independently selected from N, O, or S, and, where permitted by available valences, 1, 2, 3, 4, or 5 R b each of which may be substituted with a substituent; R b is a halogen, C 1-4 Alkyl, Amino, C 1-4 Alkyl-amino, (C 1-4 Alkyl) 2 -Amino and C 3-6 cycloalkyl; R 1 Heteroaryl, heterocyclyl, phenyl, heteroaryl-C 1-4 Alkyl, Heteroaryl-C 2-4 Alkenyl, Heteroaryl-amino, and Heteroaryl-C 1-4 alkyl-amino; Heteroaryl is a 3-7 membered monocyclic or 6-10 membered bicyclic ring system having 1, 2, 3, or 4 heteroatom ring members independently selected from N, O, or S; Heterocyclyl is a saturated or partially unsaturated 3- to 7-membered monocyclic, 6- to 10-membered bicyclic or 13- to 16-membered polycyclic ring system having 1, 2 or 3 heteroatom ring members independently selected from N, O or S; Each example of phenyl, heteroaryl, or heterocyclyl may have one or two R 1a may be substituted with a substituent; R 1a is halogen, hydroxyl, cyano, C 1-4 Alkyl, Deuterium-C 1-4 Alkyl, halo-C 1-4 Alkyl, Amino, C 1-4 Alkyl-amino, (C 1-4 Alkyl) 2 - Amino, C 1-4 Alkoxy, Deuterium-C 1-4 Alkoxy, and halo-C 1-4 alkoxy)

[0305] In one embodiment, X is O, NR x and a bond.

[0306] Another embodiment includes compounds of formula (II) where X is O.

[0307] Another embodiment is where X is NR x

[0033] The present invention includes compounds of formula (II)

[0308] Another embodiment includes compounds of formula (II) where X is a bond.

[0309] In one embodiment, R x But hydrogen and C 1-4 The compound of formula (II) includes compounds of formula (II) wherein the alkyl group is selected from alkyl, aryl ... and aryl.

[0310] Another aspect is R x is hydrogen.

[0311] Another aspect is R xis selected from methyl, ethyl, propyl, isopropyl, butyl, and tert-butyl; 1-4 This includes compounds of formula (II) in which:

[0312] Another aspect is R x is methyl.

[0313] In one embodiment, B is heterocyclyl, which is a saturated or partially unsaturated 3-7 membered monocyclic, 6-10 membered bicyclic, or 13-16 membered polycyclic ring system having 1, 2, or 3 heteroatom ring members independently selected from N, O, or S, and, where permitted by available valences, 1, 2, 3, 4, or 5 R b This includes compounds of formula (II) which may be substituted with a substituent.

[0314] Another embodiment is where B is heterocyclyl, which is a saturated or partially unsaturated 3-7 membered monocyclic, 6-10 membered bicyclic, or 13-16 membered polycyclic ring system having 1, 2, or 3 heteroatom ring members independently selected from N, O, or S, and, where permitted by available valences, one R b This includes compounds of formula (II) which are substituted with a substituent.

[0315] Another embodiment is where B is heterocyclyl, which is a saturated or partially unsaturated 3-7 membered monocyclic, 6-10 membered bicyclic, or 13-16 membered polycyclic ring system having 1, 2, or 3 heteroatom ring members independently selected from N, O, or S, and, where permitted by available valences, four R b This includes compounds of formula (II) which are substituted with a substituent.

[0316] Another embodiment is where B is heterocyclyl, which is a saturated or partially unsaturated 3-7 membered monocyclic, 6-10 membered bicyclic, or 13-16 membered polycyclic ring system having 1, 2, or 3 heteroatom ring members independently selected from N, O, or S, and where available valences permit, five Rb This includes compounds of formula (II) which are substituted with a substituent.

[0317] Another embodiment is where B is azetidinyl, tetrahydrofuranyl, pyrrolidinyl, piperidinyl, piperidin-1-olate-yl, piperazinyl, 1,4-diazepanyl, 1,2-dihydropyridinyl, 1,2,5,6-tetrahydropyridinyl, 1,2,3,6-tetrahydropyridinyl, hexahydrocyclopentapyrrol-(1H)-yl, hexahydropyrrolo[3,2-b]pyrrol-(2H)-yl, hexahydropyrrolo[3,4-b]pyrrol-(2H)-yl, octahydro-2H-pyrrolo[3,4-c]pyridinyl, octahydro-5H- Pyrrolo[3,2-c]pyridinyl, octahydro-6H-pyrrolo[3,4-b]pyridinyl, hexahydropyrrolo[1,2-a]pyrazin-(2H)-one, hexahydropyrrolo[1,2-a]pyrazin-(1H)-yl, hexahydro-1H-cyclobuta[1.2-c:1,4-c′]dipyrrol-(3H)-yl, octahydropyrrolo[1,2-a]pyrazin-(1H)-yl, octahydro-2H-pyrido[1,2-a]pyrazinyl, hexahydropyrrolo[3,4-b][1,4]oxazin-(2H)-yl, 5-azaspiro[2.4]hepta nyl, 1-azaspiro[3.3]heptanyl, 4-azaspiro[2.5]octanyl, 2-oxa-6-azaspiro[3.4]octanyl, 3-azabicyclo[3.1.0]hexanyl, 8-azabicyclo[3.2.1]octanyl, 8-azabicyclo[3.2.1]oct-2-en-yl, 9-azabicyclo[3.3.1]nonanyl, 2,5-diazabicyclo[2.2.1]heptanyl, 1,4-diazabicyclo[3.1.1]heptanyl, 3,6-diazabicyclo[3.2.0]heptanyl, 2,5-diazabicyclo[2.2.2]octanyl, 1,4-diazabicyclo[3.2.1]octanyl, 3,8-diazabicyclo[3.2.1]octanyl, 1,4-diazabicyclo[3.2.2]nonanyl, 4,7-diazaspiro[2.5]octanyl, 2,6-diazaspiro[3.3]heptanyl, 1,6-diazaspiro[3.4]octanyl, 2,6-diazaspiro[3.4]octanyl, 1,7-diazaspiro[4.4]nonanyl, 1,7-diazaspiro[3.5]nonanyl, 2,6-diazaspiro[3.5]nonanyl, 2,7-diazaspiro[3.5]nonanyl, 5,8-diazaspiro[3.5]nonanyl, 2-oxa-5,8-diazaspiro[3.5]nonanyl, 2,7-diazaspiro[4.4]nonanyl, 2,7-diazaspiro[4.5]decanyl, 2,8-diazaspiro[4.5]decanyl, 6,9-diazaspiro[4.5]decyl, 6-oxa-2,9-diazaspiro[4.5]decanyl, 2,9-diazaspiro[5.5]undecanyl, 4-azadispiro[2.1.2. 5 .3 3 ]decanyl, and 7-azadispiro[5.1.5 8 .3 6 ]hexadecanyl, where available valences permit, 1, 2, 3, 4 or 5 R b This includes compounds of formula (II) which may be substituted with a substituent.

[0318] Another embodiment is where B is azetidinyl, tetrahydrofuranyl, pyrrolidinyl, piperidinyl, piperidin-1-olate-yl, piperazinyl, 1,4-diazepanyl, 1,2-dihydropyridinyl, 1,2,5,6-tetrahydropyridinyl, 1,2,3,6-tetrahydropyridinyl, hexahydrocyclopentapyrrol-(1H)-yl, hexahydropyrrolo[3,2-b]pyrrol-(2H)-yl, hexahydropyrrolo[3,4-b]pyrrol-(2H)-yl, octahydro-2H-pyrrolo[3,4-c]pyridinyl, octahydro-5H- Pyrrolo[3,2-c]pyridinyl, octahydro-6H-pyrrolo[3,4-b]pyridinyl, hexahydropyrrolo[1,2-a]pyrazin-(2H)-one, hexahydropyrrolo[1,2-a]pyrazin-(1H)-yl, hexahydro-1H-cyclobuta[1.2-c:1,4-c′]dipyrrol-(3H)-yl, octahydropyrrolo[1,2-a]pyrazin-(1H)-yl, octahydro-2H-pyrido[1,2-a]pyrazinyl, hexahydropyrrolo[3,4-b][1,4]oxazin-(2H)-yl, 5-azaspiro[2.4]hepta nyl, 1-azaspiro[3.3]heptanyl, 4-azaspiro[2.5]octanyl, 2-oxa-6-azaspiro[3.4]octanyl, 3-azabicyclo[3.1.0]hexanyl, 8-azabicyclo[3.2.1]octanyl, 8-azabicyclo[3.2.1]oct-2-en-yl, 9-azabicyclo[3.3.1]nonanyl, 2,5-diazabicyclo[2.2.1]heptanyl, 1,4-diazabicyclo[3.1.1]heptanyl, 3,6-diazabicyclo[3.2.0]heptanyl, 2,5-diazabicyclo[2.2.2]octanyl, 1,4-diazabicyclo[3.2.1]octanyl, 3,8-diazabicyclo[3.2.1]octanyl, 1,4-diazabicyclo[3.2.2]nonanyl, 4,7-diazaspiro[2.5]octanyl, 2,6-diazaspiro[3.3]heptanyl, 1,6-diazaspiro[3.4]octanyl, 2,6-diazaspiro[3.4]octanyl, 1,7-diazaspiro[4.4]nonanyl, 1,7-diazaspiro[3.5]nonanyl, 2,6-diazaspiro[3.5]nonanyl, 2,7-diazaspiro[3.5]nonanyl, 5,8-diazaspiro[3.5]nonanyl, 2-oxa-5,8-diazaspiro[3.5]nonanyl, 2,7-diazaspiro[4.4]nonanyl, 2,7-diazaspiro[4.5]decanyl, 2,8-diazaspiro[4.5]decanyl, 6,9-diazaspiro[4.5]decyl, 6-oxa-2,9-diazaspiro[4.5]decanyl, 2,9-diazaspiro[5.5]undecanyl, 4-azadispiro[2.1.2. 5 .3 3 ]decanyl, and 7-azadispiro[5.1.5 8 .3 6 ]hexadecanyl.

[0319] Another embodiment is where B is azetidinyl, tetrahydrofuranyl, pyrrolidinyl, piperidinyl, piperidin-1-olate-yl, piperazinyl, 1,4-diazepanyl, 1,2-dihydropyridinyl, 1,2,5,6-tetrahydropyridinyl, 1,2,3,6-tetrahydropyridinyl, hexahydrocyclopentapyrrol-(1H)-yl, hexahydropyrrolo[3,2-b]pyrrol-(2H)-yl, hexahydropyrrolo[3,4-b]pyrrol-(2H)-yl, octahydro-2H-pyrrolo[3,4-c]pyridinyl, octahydro-5H- Pyrrolo[3,2-c]pyridinyl, octahydro-6H-pyrrolo[3,4-b]pyridinyl, hexahydropyrrolo[1,2-a]pyrazin-(2H)-one, hexahydropyrrolo[1,2-a]pyrazin-(1H)-yl, hexahydro-1H-cyclobuta[1.2-c:1,4-c′]dipyrrol-(3H)-yl, octahydropyrrolo[1,2-a]pyrazin-(1H)-yl, octahydro-2H-pyrido[1,2-a]pyrazinyl, hexahydropyrrolo[3,4-b][1,4]oxazin-(2H)-yl, 5-azaspiro[2.4]hepta nyl, 1-azaspiro[3.3]heptanyl, 4-azaspiro[2.5]octanyl, 2-oxa-6-azaspiro[3.4]octanyl, 3-azabicyclo[3.1.0]hexanyl, 8-azabicyclo[3.2.1]octanyl, 8-azabicyclo[3.2.1]oct-2-en-yl, 9-azabicyclo[3.3.1]nonanyl, 2,5-diazabicyclo[2.2.1]heptanyl, 1,4-diazabicyclo[3.1.1]heptanyl, 3,6-diazabicyclo[3.2.0]heptanyl, 2,5-diazabicyclo[2.2.2]octanyl, 1,4-diazabicyclo[3.2.1]octanyl, 3,8-diazabicyclo[3.2.1]octanyl, 1,4-diazabicyclo[3.2.2]nonanyl, 4,7-diazaspiro[2.5]octanyl, 2,6-diazaspiro[3.3]heptanyl, 1,6-diazaspiro[3.4]octanyl, 2,6-diazaspiro[3.4]octanyl, 1,7-diazaspiro[4.4]nonanyl, 1,7-diazaspiro[3.5]nonanyl, 2,6-diazaspiro[3.5]nonanyl, 2,7-diazaspiro[3.5]nonanyl, 5,8-diazaspiro[3.5]nonanyl, 2-oxa-5,8-diazaspiro[3.5]nonanyl, 2,7-diazaspiro[4.4]nonanyl, 2,7-diazaspiro[4.5]decanyl, 2,8-diazaspiro[4.5]decanyl, 6,9-diazaspiro[4.5]decyl, 6-oxa-2,9-diazaspiro[4.5]decanyl, 2,9-diazaspiro[5.5]undecanyl, 4-azadispiro[2.1.2. 5 .3 3 ]decanyl, and 7-azadispiro[5.1.5 8 .3 6 ]hexadecanyl, where available valences permit, one R b This includes compounds of formula (II) which may be substituted with a substituent.

[0320] Another embodiment is where B is azetidinyl, tetrahydrofuranyl, pyrrolidinyl, piperidinyl, piperidin-1-olate-yl, piperazinyl, 1,4-diazepanyl, 1,2-dihydropyridinyl, 1,2,5,6-tetrahydropyridinyl, 1,2,3,6-tetrahydropyridinyl, hexahydrocyclopentapyrrol-(1H)-yl, hexahydropyrrolo[3,2-b]pyrrol-(2H)-yl, hexahydropyrrolo[3,4-b]pyrrol-(2H)-yl, octahydro-2H-pyrrolo[3,4-c]pyridinyl, octahydro-5H- Pyrrolo[3,2-c]pyridinyl, octahydro-6H-pyrrolo[3,4-b]pyridinyl, hexahydropyrrolo[1,2-a]pyrazin-(2H)-one, hexahydropyrrolo[1,2-a]pyrazin-(1H)-yl, hexahydro-1H-cyclobuta[1.2-c:1,4-c′]dipyrrol-(3H)-yl, octahydropyrrolo[1,2-a]pyrazin-(1H)-yl, octahydro-2H-pyrido[1,2-a]pyrazinyl, hexahydropyrrolo[3,4-b][1,4]oxazin-(2H)-yl, 5-azaspiro[2.4]hepta nyl, 1-azaspiro[3.3]heptanyl, 4-azaspiro[2.5]octanyl, 2-oxa-6-azaspiro[3.4]octanyl, 3-azabicyclo[3.1.0]hexanyl, 8-azabicyclo[3.2.1]octanyl, 8-azabicyclo[3.2.1]oct-2-en-yl, 9-azabicyclo[3.3.1]nonanyl, 2,5-diazabicyclo[2.2.1]heptanyl, 1,4-diazabicyclo[3.1.1]heptanyl, 3,6-diazabicyclo[3.2.0]heptanyl, 2,5-diazabicyclo[2.2.2]octanyl, 1,4-diazabicyclo[3.2.1]octanyl, 3,8-diazabicyclo[3.2.1]octanyl, 1,4-diazabicyclo[3.2.2]nonanyl, 4,7-diazaspiro[2.5]octanyl, 2,6-diazaspiro[3.3]heptanyl, 1,6-diazaspiro[3.4]octanyl, 2,6-diazaspiro[3.4]octanyl, 1,7-diazaspiro[4.4]nonanyl, 1,7-diazaspiro[3.5]nonanyl, 2,6-diazaspiro[3.5]nonanyl, 2,7-diazaspiro[3.5]nonanyl, 5,8-diazaspiro[3.5]nonanyl, 2-oxa-5,8-diazaspiro[3.5]nonanyl, 2,7-diazaspiro[4.4]nonanyl, 2,7-diazaspiro[4.5]decanyl, 2,8-diazaspiro[4.5]decanyl, 6,9-diazaspiro[4.5]decyl, 6-oxa-2,9-diazaspiro[4.5]decanyl, 2,9-diazaspiro[5.5]undecanyl, 4-azadispiro[2.1.2. 5 .3 3 ]decanyl, and 7-azadispiro[5.1.5 8 .3 6 ]hexadecanyl, where available valences permit, two R b This includes compounds of formula (II) which may be substituted with a substituent.

[0321] Another embodiment is where B is azetidinyl, tetrahydrofuranyl, pyrrolidinyl, piperidinyl, piperidin-1-olate-yl, piperazinyl, 1,4-diazepanyl, 1,2-dihydropyridinyl, 1,2,5,6-tetrahydropyridinyl, 1,2,3,6-tetrahydropyridinyl, hexahydrocyclopentapyrrol-(1H)-yl, hexahydropyrrolo[3,2-b]pyrrol-(2H)-yl, hexahydropyrrolo[3,4-b]pyrrol-(2H)-yl, octahydro-2H-pyrrolo[3,4-c]pyridinyl, octahydro-5H- Pyrrolo[3,2-c]pyridinyl, octahydro-6H-pyrrolo[3,4-b]pyridinyl, hexahydropyrrolo[1,2-a]pyrazin-(2H)-one, hexahydropyrrolo[1,2-a]pyrazin-(1H)-yl, hexahydro-1H-cyclobuta[1.2-c:1,4-c′]dipyrrol-(3H)-yl, octahydropyrrolo[1,2-a]pyrazin-(1H)-yl, octahydro-2H-pyrido[1,2-a]pyrazinyl, hexahydropyrrolo[3,4-b][1,4]oxazin-(2H)-yl, 5-azaspiro[2.4]hepta nyl, 1-azaspiro[3.3]heptanyl, 4-azaspiro[2.5]octanyl, 2-oxa-6-azaspiro[3.4]octanyl, 3-azabicyclo[3.1.0]hexanyl, 8-azabicyclo[3.2.1]octanyl, 8-azabicyclo[3.2.1]oct-2-en-yl, 9-azabicyclo[3.3.1]nonanyl, 2,5-diazabicyclo[2.2.1]heptanyl, 1,4-diazabicyclo[3.1.1]heptanyl, 3,6-diazabicyclo[3.2.0]heptanyl, 2,5-diazabicyclo[2.2.2]octanyl, 1,4-diazabicyclo[3.2.1]octanyl, 3,8-diazabicyclo[3.2.1]octanyl, 1,4-diazabicyclo[3.2.2]nonanyl, 4,7-diazaspiro[2.5]octanyl, 2,6-diazaspiro[3.3]heptanyl, 1,6-diazaspiro[3.4]octanyl, 2,6-diazaspiro[3.4]octanyl, 1,7-diazaspiro[4.4]nonanyl, 1,7-diazaspiro[3.5]nonanyl, 2,6-diazaspiro[3.5]nonanyl, 2,7-diazaspiro[3.5]nonanyl, 5,8-diazaspiro[3.5]nonanyl, 2-oxa-5,8-diazaspiro[3.5]nonanyl, 2,7-diazaspiro[4.4]nonanyl, 2,7-diazaspiro[4.5]decanyl, 2,8-diazaspiro[4.5]decanyl, 6,9-diazaspiro[4.5]decyl, 6-oxa-2,9-diazaspiro[4.5]decanyl, 2,9-diazaspiro[5.5]undecanyl, 4-azadispiro[2.1.2. 5 .3 3 ]decanyl, and 7-azadispiro[5.1.5 8 .3 6 ]hexadecanyl, where available valences permit, and three R b This includes compounds of formula (II) which may be substituted with a substituent.

[0322] Another embodiment is where B is azetidinyl, tetrahydrofuranyl, pyrrolidinyl, piperidinyl, piperidin-1-olate-yl, piperazinyl, 1,4-diazepanyl, 1,2-dihydropyridinyl, 1,2,5,6-tetrahydropyridinyl, 1,2,3,6-tetrahydropyridinyl, hexahydrocyclopentapyrrol-(1H)-yl, hexahydropyrrolo[3,2-b]pyrrol-(2H)-yl, hexahydropyrrolo[3,4-b]pyrrol-(2H)-yl, octahydro-2H-pyrrolo[3,4-c]pyridinyl, octahydro-5H- Pyrrolo[3,2-c]pyridinyl, octahydro-6H-pyrrolo[3,4-b]pyridinyl, hexahydropyrrolo[1,2-a]pyrazin-(2H)-one, hexahydropyrrolo[1,2-a]pyrazin-(1H)-yl, hexahydro-1H-cyclobuta[1.2-c:1,4-c′]dipyrrol-(3H)-yl, octahydropyrrolo[1,2-a]pyrazin-(1H)-yl, octahydro-2H-pyrido[1,2-a]pyrazinyl, hexahydropyrrolo[3,4-b][1,4]oxazin-(2H)-yl, 5-azaspiro[2.4]hepta nyl, 1-azaspiro[3.3]heptanyl, 4-azaspiro[2.5]octanyl, 2-oxa-6-azaspiro[3.4]octanyl, 3-azabicyclo[3.1.0]hexanyl, 8-azabicyclo[3.2.1]octanyl, 8-azabicyclo[3.2.1]oct-2-en-yl, 9-azabicyclo[3.3.1]nonanyl, 2,5-diazabicyclo[2.2.1]heptanyl, 1,4-diazabicyclo[3.1.1]heptanyl, 3,6-diazabicyclo[3.2.0]heptanyl, 2,5-diazabicyclo[2.2.2]octanyl, 1,4-diazabicyclo[3.2.1]octanyl, 3,8-diazabicyclo[3.2.1]octanyl, 1,4-diazabicyclo[3.2.2]nonanyl, 4,7-diazaspiro[2.5]octanyl, 2,6-diazaspiro[3.3]heptanyl, 1,6-diazaspiro[3.4]octanyl, 2,6-diazaspiro[3.4]octanyl, 1,7-diazaspiro[4.4]nonanyl, 1,7-diazaspiro[3.5]nonanyl, 2,6-diazaspiro[3.5]nonanyl, 2,7-diazaspiro[3.5]nonanyl, 5,8-diazaspiro[3.5]nonanyl, 2-oxa-5,8-diazaspiro[3.5]nonanyl, 2,7-diazaspiro[4.4]nonanyl, 2,7-diazaspiro[4.5]decanyl, 2,8-diazaspiro[4.5]decanyl, 6,9-diazaspiro[4.5]decyl, 6-oxa-2,9-diazaspiro[4.5]decanyl, 2,9-diazaspiro[5.5]undecanyl, 4-azadispiro[2.1.2. 5 .3 3 ]decanyl, and 7-azadispiro[5.1.5 8 .3 6 ]hexadecanyl, where available valences permit, four R b This includes compounds of formula (II) which may be substituted with a substituent.

[0323] Another embodiment is where B is azetidinyl, tetrahydrofuranyl, pyrrolidinyl, piperidinyl, piperidin-1-olate-yl, piperazinyl, 1,4-diazepanyl, 1,2-dihydropyridinyl, 1,2,5,6-tetrahydropyridinyl, 1,2,3,6-tetrahydropyridinyl, hexahydrocyclopentapyrrol-(1H)-yl, hexahydropyrrolo[3,2-b]pyrrol-(2H)-yl, hexahydropyrrolo[3,4-b]pyrrol-(2H)-yl, octahydro-2H-pyrrolo[3,4-c]pyridinyl, octahydro-5H- Pyrrolo[3,2-c]pyridinyl, octahydro-6H-pyrrolo[3,4-b]pyridinyl, hexahydropyrrolo[1,2-a]pyrazin-(2H)-one, hexahydropyrrolo[1,2-a]pyrazin-(1H)-yl, hexahydro-1H-cyclobuta[1.2-c:1,4-c′]dipyrrol-(3H)-yl, octahydropyrrolo[1,2-a]pyrazin-(1H)-yl, octahydro-2H-pyrido[1,2-a]pyrazinyl, hexahydropyrrolo[3,4-b][1,4]oxazin-(2H)-yl, 5-azaspiro[2.4]hepta nyl, 1-azaspiro[3.3]heptanyl, 4-azaspiro[2.5]octanyl, 2-oxa-6-azaspiro[3.4]octanyl, 3-azabicyclo[3.1.0]hexanyl, 8-azabicyclo[3.2.1]octanyl, 8-azabicyclo[3.2.1]oct-2-en-yl, 9-azabicyclo[3.3.1]nonanyl, 2,5-diazabicyclo[2.2.1]heptanyl, 1,4-diazabicyclo[3.1.1]heptanyl, 3,6-diazabicyclo[3.2.0]heptanyl, 2,5-diazabicyclo[2.2.2]octanyl, 1,4-diazabicyclo[3.2.1]octanyl, 3,8-diazabicyclo[3.2.1]octanyl, 1,4-diazabicyclo[3.2.2]nonanyl, 4,7-diazaspiro[2.5]octanyl, 2,6-diazaspiro[3.3]heptanyl, 1,6-diazaspiro[3.4]octanyl, 2,6-diazaspiro[3.4]octanyl, 1,7-diazaspiro[4.4]nonanyl, 1,7-diazaspiro[3.5]nonanyl, 2,6-diazaspiro[3.5]nonanyl, 2,7-diazaspiro[3.5]nonanyl, 5,8-diazaspiro[3.5]nonanyl, 2-oxa-5,8-diazaspiro[3.5]nonanyl, 2,7-diazaspiro[4.4]nonanyl, 2,7-diazaspiro[4.5]decanyl, 2,8-diazaspiro[4.5]decanyl, 6,9-diazaspiro[4.5]decyl, 6-oxa-2,9-diazaspiro[4.5]decanyl, 2,9-diazaspiro[5.5]undecanyl, 4-azadispiro[2.1.2. 5 .3 3 ]decanyl, and 7-azadispiro[5.1.5 8 .3 6 ]hexadecanyl, where available valences permit, five R b This includes compounds of formula (II) which may be substituted with a substituent.

[0324] Another embodiment includes compounds of formula (II) where B is unsubstituted heterocyclyl selected from pyrrolidinyl, piperidinyl, and piperazinyl.

[0325] Another embodiment is where B is heterocyclyl selected from pyrrolidinyl, piperidinyl, and piperazinyl, and where available valences permit, one R b This includes compounds of formula (II) which are substituted with a substituent.

[0326] Another embodiment is where B is heterocyclyl selected from pyrrolidinyl, piperidinyl, and piperazinyl, and where available valences permit, two R b This includes compounds of formula (II) which are substituted with a substituent.

[0327] Another embodiment is where B is heterocyclyl selected from pyrrolidinyl, piperidinyl, and piperazinyl, and where available valences permit, three R b This includes compounds of formula (II) which are substituted with a substituent.

[0328] Another embodiment is where B is heterocyclyl selected from pyrrolidinyl, piperidinyl, and piperazinyl, and where available valences permit, four Rb This includes compounds of formula (II) which are substituted with a substituent.

[0329] Another embodiment is where B is heterocyclyl selected from pyrrolidinyl, piperidinyl, and piperazinyl, and where available valences permit, five R b This includes compounds of formula (II) which are substituted with a substituent.

[0330] Another embodiment is where B is pyrrolidinyl and, where available valences permit, one R b This includes compounds of formula (II) which are substituted with a substituent.

[0331] Another embodiment is where B is piperidinyl and, where available valences allow, 4 or 5 R b This includes compounds of formula (II) which are substituted with a substituent.

[0332] Another embodiment is where B is piperidinyl and, where available valences allow, four R b This includes compounds of formula (II) which are substituted with a substituent.

[0333] Another embodiment is where B is piperidinyl and, where available valences permit, five R b This includes compounds of formula (II) which are substituted with a substituent.

[0334] Another embodiment is where B is heterocyclyl selected from piperazinyl and, where available valences permit, one R b This includes compounds of formula (II) which are substituted with a substituent.

[0335] Another embodiment is where B is azetidin-1-yl, tetrahydrofuran-3-yl, pyrrolidin-1-yl, pyrrolidin-3-yl, piperidin-1-yl, piperidin-3-yl, piperidin-4-yl, piperidin-1-olate-4-yl, piperazin-1-yl, 1,4-diazepin-1-yl, 1,2-dihydropyridin-2-yl, 1,2-dihydropyridin-3-yl, 1,2-dihydropyridin-4-yl, 1,2-dihydropyridin-5-yl, 1,2-dihydropyridin-6-yl, 1,2,5,6-tetrahydropyridine-5-yl, 1,2,5,6-tetrahydropyridine ... -yl, 1,2,3,6-tetrahydropyridin-4-yl, hexahydrocyclopentapyrrol-2(1H)-yl, hexahydropyrrolo[3,2-b]pyrrol-1(2H)-yl, hexahydropyrrolo[3,4-b]pyrrol-1(2H)-yl, hexahydropyrrolo[3,4-c]pyrrol-1(1H)-yl, hexahydropyrrolo[3,4-c]pyrrol-2(1H)-yl, hexahydropyrrolo[3,4-c]pyrrol-5(1H)-yl, octahydro-5H-pyrrolo[3,2-c]pyridin-5-yl, octahydro-6H- Pyrrolo[3,4-b]pyridin-6-yl, hexahydropyrrolo[1,2-a]pyrazin-6(2H)-one, hexahydropyrrolo[1,2-a]pyrazin-2(1H)-yl, hexahydro-1H-cyclobuta[1.2-c:1,4-c′]dipyrrol-2(3H)-yl, octahydropyrrolo[1,2-a]pyrazin-2(1H)-yl, octahydro-2H-pyrido[1,2-a]pyrazin-2-yl, hexahydropyrrolo[3,4-b][1,4]oxazin-6(2H)-yl, 5-azaspiro[2.4]heptan-5-yl, 1- Azaspiro[3.3]heptan-2-yl, 4-azaspiro[2.5]octan-7-yl, 2-oxa-6-azaspiro[3.4]octan-6-yl, 3-azabicyclo[3.1.0]hexan-3-yl, 8-azabicyclo[3.2.1]octan-3-yl, 8-azabicyclo[3.2.1]oct-2-en-3-yl, 9-azabicyclo[3.3.1]nonan-3-yl, 2,5-diazabicyclo[2.2.1]heptan-2-yl, 1,4-diazabicyclo[3.1.1]heptan-4-yl, 3,6-diazabicyclo[3.2.0]heptan-3-yl, 3,6-diazabicyclo[3.2.0]heptan-6-yl, 2,5-diazabicyclo[2.2.2]octan-2-yl, 1,4-diazabicyclo[3.2.1]octan-4-yl, 3,8-diazabicyclo[3.2.1]octan-3-yl, 1,4-diazabicyclo[3.2.2]nonan-4-yl, 4,7-diazaspiro[2.5]octan-4-yl, 4,7-diazaspiro[2.5]octan-4-yl, 2,6-diazaspiro[3.3]heptan-2-yl, 1,6-diazaspiro[3.4]octan-6-yl, 2,6-diazaspiro[3.4]octan-2-yl, 2,6-diazaspiro[3.4]octan-6-yl, 1,7-diazaspiro[4.4]nonan-1-yl, 1,7-diazaspiro[4.4]nonan-7-yl, 1,7-diazaspiro[3.5]nonane- 7-yl, 2,6-diazaspiro[3.5]nonan-2-yl, 2,6-diazaspiro[3.5]nonan-6-yl, 1,7-diazaspiro[3.5]nonan-7-yl, 2,7-diazaspiro[3.5]nonan-2-yl, 2,7-diazaspiro[3.5]nonan-7-yl, 5,8-diazaspiro[3.5]nonan-8-yl, 2-oxa-5,8-diazaspiro[3.5]nonan-8-yl, 2,7-diaza Zaspiro[4.4]nonan-2-yl, 2,7-diazaspiro[4.5]decan-2-yl, 2,7-diazaspiro[4.5]decan-7-yl, 2,8-diazaspiro[4.5]decan-8-yl, 6,9-diazaspiro[4.5]decan-9-yl, 6-oxa-2,9-diazaspiro[4.5]decan-2-yl, 2,9-diazaspiro[5.5]undecan-9-yl, 4-azadispiro[2.1.2]undecan-2. 5 .3 3 ]decan-9-yl, and 7-azadispiro[5.1.5 8 .3 6 ]hexadecan-15-yl, where available valences permit, one, two, three, four or five R b This includes compounds of formula (II) which may be substituted with a substituent.

[0336] Another embodiment is where B is azetidin-1-yl, tetrahydrofuran-3-yl, pyrrolidin-1-yl, pyrrolidin-3-yl, piperidin-1-yl, piperidin-3-yl, piperidin-4-yl, piperidin-1-olate-4-yl, piperazin-1-yl, 1,4-diazepin-1-yl, 1,2-dihydropyridin-2-yl, 1,2-dihydropyridin-3-yl, 1,2-dihydropyridin-4-yl, 1,2-dihydropyridin-5-yl, 1,2-dihydropyridin-6-yl, 1,2,5,6-tetrahydropyridine-5-yl, 1,2,5,6-tetrahydropyridine ... -yl, 1,2,3,6-tetrahydropyridin-4-yl, hexahydrocyclopentapyrrol-2(1H)-yl, hexahydropyrrolo[3,2-b]pyrrol-1(2H)-yl, hexahydropyrrolo[3,4-b]pyrrol-1(2H)-yl, hexahydropyrrolo[3,4-c]pyrrol-1(1H)-yl, hexahydropyrrolo[3,4-c]pyrrol-2(1H)-yl, hexahydropyrrolo[3,4-c]pyrrol-5(1H)-yl, octahydro-5H-pyrrolo[3,2-c]pyridin-5-yl, octahydro-6H- Pyrrolo[3,4-b]pyridin-6-yl, hexahydropyrrolo[1,2-a]pyrazin-6(2H)-one, hexahydropyrrolo[1,2-a]pyrazin-2(1H)-yl, hexahydro-1H-cyclobuta[1.2-c:1,4-c′]dipyrrol-2(3H)-yl, octahydropyrrolo[1,2-a]pyrazin-2(1H)-yl, octahydro-2H-pyrido[1,2-a]pyrazin-2-yl, hexahydropyrrolo[3,4-b][1,4]oxazin-6(2H)-yl, 5-azaspiro[2.4]heptan-5-yl, 1- Azaspiro[3.3]heptan-2-yl, 4-azaspiro[2.5]octan-7-yl, 2-oxa-6-azaspiro[3.4]octan-6-yl, 3-azabicyclo[3.1.0]hexan-3-yl, 8-azabicyclo[3.2.1]octan-3-yl, 8-azabicyclo[3.2.1]oct-2-en-3-yl, 9-azabicyclo[3.3.1]nonan-3-yl, 2,5-diazabicyclo[2.2.1]heptan-2-yl, 1,4-diazabicyclo[3.1.1]heptan-4-yl, 3,6-diazabicyclo[3.2.0]heptan-3-yl, 3,6-diazabicyclo[3.2.0]heptan-6-yl, 2,5-diazabicyclo[2.2.2]octan-2-yl, 1,4-diazabicyclo[3.2.1]octan-4-yl, 3,8-diazabicyclo[3.2.1]octan-3-yl, 1,4-diazabicyclo[3.2.2]nonan-4-yl, 4,7-diazaspiro[2.5]octan-4-yl, 4,7-diazaspiro[2.5]octan-4-yl, 2,6-diazaspiro[3.3]heptan-2-yl, 1,6-diazaspiro[3.4]octan-6-yl, 2,6-diazaspiro[3.4]octan-2-yl, 2,6-diazaspiro[3.4]octan-6-yl, 1,7-diazaspiro[4.4]nonan-1-yl, 1,7-diazaspiro[4.4]nonan-7-yl, 1,7-diazaspiro[3.5]nonane- 7-yl, 2,6-diazaspiro[3.5]nonan-2-yl, 2,6-diazaspiro[3.5]nonan-6-yl, 1,7-diazaspiro[3.5]nonan-7-yl, 2,7-diazaspiro[3.5]nonan-2-yl, 2,7-diazaspiro[3.5]nonan-7-yl, 5,8-diazaspiro[3.5]nonan-8-yl, 2-oxa-5,8-diazaspiro[3.5]nonan-8-yl, 2,7-diaza Zaspiro[4.4]nonan-2-yl, 2,7-diazaspiro[4.5]decan-2-yl, 2,7-diazaspiro[4.5]decan-7-yl, 2,8-diazaspiro[4.5]decan-8-yl, 6,9-diazaspiro[4.5]decan-9-yl, 6-oxa-2,9-diazaspiro[4.5]decan-2-yl, 2,9-diazaspiro[5.5]undecan-9-yl, 4-azadispiro[2.1.2]undecan-2. 5 .3 3 ]decan-9-yl, and 7-azadispiro[5.1.5 8 .3 6 ]hexadecan-15-yl.

[0337] Another embodiment is where B is azetidin-1-yl, tetrahydrofuran-3-yl, pyrrolidin-1-yl, pyrrolidin-3-yl, piperidin-1-yl, piperidin-3-yl, piperidin-4-yl, piperidin-1-olate-4-yl, piperazin-1-yl, 1,4-diazepin-1-yl, 1,2-dihydropyridin-2-yl, 1,2-dihydropyridin-3-yl, 1,2-dihydropyridin-4-yl, 1,2-dihydropyridin-5-yl, 1,2-dihydropyridin-6-yl, 1,2,5,6-tetrahydropyridine-5-yl, 1,2,5,6-tetrahydropyridine ... -yl, 1,2,3,6-tetrahydropyridin-4-yl, hexahydrocyclopentapyrrol-2(1H)-yl, hexahydropyrrolo[3,2-b]pyrrol-1(2H)-yl, hexahydropyrrolo[3,4-b]pyrrol-1(2H)-yl, hexahydropyrrolo[3,4-c]pyrrol-1(1H)-yl, hexahydropyrrolo[3,4-c]pyrrol-2(1H)-yl, hexahydropyrrolo[3,4-c]pyrrol-5(1H)-yl, octahydro-5H-pyrrolo[3,2-c]pyridin-5-yl, octahydro-6H- Pyrrolo[3,4-b]pyridin-6-yl, hexahydropyrrolo[1,2-a]pyrazin-6(2H)-one, hexahydropyrrolo[1,2-a]pyrazin-2(1H)-yl, hexahydro-1H-cyclobuta[1.2-c:1,4-c′]dipyrrol-2(3H)-yl, octahydropyrrolo[1,2-a]pyrazin-2(1H)-yl, octahydro-2H-pyrido[1,2-a]pyrazin-2-yl, hexahydropyrrolo[3,4-b][1,4]oxazin-6(2H)-yl, 5-azaspiro[2.4]heptan-5-yl, 1- Azaspiro[3.3]heptan-2-yl, 4-azaspiro[2.5]octan-7-yl, 2-oxa-6-azaspiro[3.4]octan-6-yl, 3-azabicyclo[3.1.0]hexan-3-yl, 8-azabicyclo[3.2.1]octan-3-yl, 8-azabicyclo[3.2.1]oct-2-en-3-yl, 9-azabicyclo[3.3.1]nonan-3-yl, 2,5-diazabicyclo[2.2.1]heptan-2-yl, 1,4-diazabicyclo[3.1.1]heptan-4-yl, 3,6-diazabicyclo[3.2.0]heptan-3-yl, 3,6-diazabicyclo[3.2.0]heptan-6-yl, 2,5-diazabicyclo[2.2.2]octan-2-yl, 1,4-diazabicyclo[3.2.1]octan-4-yl, 3,8-diazabicyclo[3.2.1]octan-3-yl, 1,4-diazabicyclo[3.2.2]nonan-4-yl, 4,7-diazaspiro[2.5]octan-4-yl, 4,7-diazaspiro[2.5]octan-4-yl, 2,6-diazaspiro[3.3]heptan-2-yl, 1,6-diazaspiro[3.4]octan-6-yl, 2,6-diazaspiro[3.4]octan-2-yl, 2,6-diazaspiro[3.4]octan-6-yl, 1,7-diazaspiro[4.4]nonan-1-yl, 1,7-diazaspiro[4.4]nonan-7-yl, 1,7-diazaspiro[3.5]nonane- 7-yl, 2,6-diazaspiro[3.5]nonan-2-yl, 2,6-diazaspiro[3.5]nonan-6-yl, 1,7-diazaspiro[3.5]nonan-7-yl, 2,7-diazaspiro[3.5]nonan-2-yl, 2,7-diazaspiro[3.5]nonan-7-yl, 5,8-diazaspiro[3.5]nonan-8-yl, 2-oxa-5,8-diazaspiro[3.5]nonan-8-yl, 2,7-diaza Zaspiro[4.4]nonan-2-yl, 2,7-diazaspiro[4.5]decan-2-yl, 2,7-diazaspiro[4.5]decan-7-yl, 2,8-diazaspiro[4.5]decan-8-yl, 6,9-diazaspiro[4.5]decan-9-yl, 6-oxa-2,9-diazaspiro[4.5]decan-2-yl, 2,9-diazaspiro[5.5]undecan-9-yl, 4-azadispiro[2.1.2]undecan-2. 5 .3 3 ]decan-9-yl, and 7-azadispiro[5.1.5 8 .3 6 ]hexadecan-15-yl, and, if permitted by available valences, one R b This includes compounds of formula (II) which are substituted with a substituent.

[0338] Another embodiment is where B is azetidin-1-yl, tetrahydrofuran-3-yl, pyrrolidin-1-yl, pyrrolidin-3-yl, piperidin-1-yl, piperidin-3-yl, piperidin-4-yl, piperidin-1-olate-4-yl, piperazin-1-yl, 1,4-diazepin-1-yl, 1,2-dihydropyridin-2-yl, 1,2-dihydropyridin-3-yl, 1,2-dihydropyridin-4-yl, 1,2-dihydropyridin-5-yl, 1,2-dihydropyridin-6-yl, 1,2,5,6-tetrahydropyridine-5-yl, 1,2,5,6-tetrahydropyridine ... -yl, 1,2,3,6-tetrahydropyridin-4-yl, hexahydrocyclopentapyrrol-2(1H)-yl, hexahydropyrrolo[3,2-b]pyrrol-1(2H)-yl, hexahydropyrrolo[3,4-b]pyrrol-1(2H)-yl, hexahydropyrrolo[3,4-c]pyrrol-1(1H)-yl, hexahydropyrrolo[3,4-c]pyrrol-2(1H)-yl, hexahydropyrrolo[3,4-c]pyrrol-5(1H)-yl, octahydro-5H-pyrrolo[3,2-c]pyridin-5-yl, octahydro-6H- Pyrrolo[3,4-b]pyridin-6-yl, hexahydropyrrolo[1,2-a]pyrazin-6(2H)-one, hexahydropyrrolo[1,2-a]pyrazin-2(1H)-yl, hexahydro-1H-cyclobuta[1.2-c:1,4-c′]dipyrrol-2(3H)-yl, octahydropyrrolo[1,2-a]pyrazin-2(1H)-yl, octahydro-2H-pyrido[1,2-a]pyrazin-2-yl, hexahydropyrrolo[3,4-b][1,4]oxazin-6(2H)-yl, 5-azaspiro[2.4]heptan-5-yl, 1- Azaspiro[3.3]heptan-2-yl, 4-azaspiro[2.5]octan-7-yl, 2-oxa-6-azaspiro[3.4]octan-6-yl, 3-azabicyclo[3.1.0]hexan-3-yl, 8-azabicyclo[3.2.1]octan-3-yl, 8-azabicyclo[3.2.1]oct-2-en-3-yl, 9-azabicyclo[3.3.1]nonan-3-yl, 2,5-diazabicyclo[2.2.1]heptan-2-yl, 1,4-diazabicyclo[3.1.1]heptan-4-yl, 3,6-diazabicyclo[3.2.0]heptan-3-yl, 3,6-diazabicyclo[3.2.0]heptan-6-yl, 2,5-diazabicyclo[2.2.2]octan-2-yl, 1,4-diazabicyclo[3.2.1]octan-4-yl, 3,8-diazabicyclo[3.2.1]octan-3-yl, 1,4-diazabicyclo[3.2.2]nonan-4-yl, 4,7-diazaspiro[2.5]octan-4-yl, 4,7-diazaspiro[2.5]octan-4-yl, 2,6-diazaspiro[3.3]heptan-2-yl, 1,6-diazaspiro[3.4]octan-6-yl, 2,6-diazaspiro[3.4]octan-2-yl, 2,6-diazaspiro[3.4]octan-6-yl, 1,7-diazaspiro[4.4]nonan-1-yl, 1,7-diazaspiro[4.4]nonan-7-yl, 1,7-diazaspiro[3.5]nonane- 7-yl, 2,6-diazaspiro[3.5]nonan-2-yl, 2,6-diazaspiro[3.5]nonan-6-yl, 1,7-diazaspiro[3.5]nonan-7-yl, 2,7-diazaspiro[3.5]nonan-2-yl, 2,7-diazaspiro[3.5]nonan-7-yl, 5,8-diazaspiro[3.5]nonan-8-yl, 2-oxa-5,8-diazaspiro[3.5]nonan-8-yl, 2,7-diaza Zaspiro[4.4]nonan-2-yl, 2,7-diazaspiro[4.5]decan-2-yl, 2,7-diazaspiro[4.5]decan-7-yl, 2,8-diazaspiro[4.5]decan-8-yl, 6,9-diazaspiro[4.5]decan-9-yl, 6-oxa-2,9-diazaspiro[4.5]decan-2-yl, 2,9-diazaspiro[5.5]undecan-9-yl, 4-azadispiro[2.1.2]undecan-2. 5 .3 3 ]decan-9-yl, and 7-azadispiro[5.1.5 8 .3 6 ]hexadecan-15-yl, and where available valences permit, two R b This includes compounds of formula (II) which are substituted with a substituent.

[0339] Another embodiment is where B is azetidin-1-yl, tetrahydrofuran-3-yl, pyrrolidin-1-yl, pyrrolidin-3-yl, piperidin-1-yl, piperidin-3-yl, piperidin-4-yl, piperidin-1-olate-4-yl, piperazin-1-yl, 1,4-diazepin-1-yl, 1,2-dihydropyridin-2-yl, 1,2-dihydropyridin-3-yl, 1,2-dihydropyridin-4-yl, 1,2-dihydropyridin-5-yl, 1,2-dihydropyridin-6-yl, 1,2,5,6-tetrahydropyridine-5-yl, 1,2,5,6-tetrahydropyridine ... -yl, 1,2,3,6-tetrahydropyridin-4-yl, hexahydrocyclopentapyrrol-2(1H)-yl, hexahydropyrrolo[3,2-b]pyrrol-1(2H)-yl, hexahydropyrrolo[3,4-b]pyrrol-1(2H)-yl, hexahydropyrrolo[3,4-c]pyrrol-1(1H)-yl, hexahydropyrrolo[3,4-c]pyrrol-2(1H)-yl, hexahydropyrrolo[3,4-c]pyrrol-5(1H)-yl, octahydro-5H-pyrrolo[3,2-c]pyridin-5-yl, octahydro-6H- Pyrrolo[3,4-b]pyridin-6-yl, hexahydropyrrolo[1,2-a]pyrazin-6(2H)-one, hexahydropyrrolo[1,2-a]pyrazin-2(1H)-yl, hexahydro-1H-cyclobuta[1.2-c:1,4-c′]dipyrrol-2(3H)-yl, octahydropyrrolo[1,2-a]pyrazin-2(1H)-yl, octahydro-2H-pyrido[1,2-a]pyrazin-2-yl, hexahydropyrrolo[3,4-b][1,4]oxazin-6(2H)-yl, 5-azaspiro[2.4]heptan-5-yl, 1- Azaspiro[3.3]heptan-2-yl, 4-azaspiro[2.5]octan-7-yl, 2-oxa-6-azaspiro[3.4]octan-6-yl, 3-azabicyclo[3.1.0]hexan-3-yl, 8-azabicyclo[3.2.1]octan-3-yl, 8-azabicyclo[3.2.1]oct-2-en-3-yl, 9-azabicyclo[3.3.1]nonan-3-yl, 2,5-diazabicyclo[2.2.1]heptan-2-yl, 1,4-diazabicyclo[3.1.1]heptan-4-yl, 3,6-diazabicyclo[3.2.0]heptan-3-yl, 3,6-diazabicyclo[3.2.0]heptan-6-yl, 2,5-diazabicyclo[2.2.2]octan-2-yl, 1,4-diazabicyclo[3.2.1]octan-4-yl, 3,8-diazabicyclo[3.2.1]octan-3-yl, 1,4-diazabicyclo[3.2.2]nonan-4-yl, 4,7-diazaspiro[2.5]octan-4-yl, 4,7-diazaspiro[2.5]octan-4-yl, 2,6-diazaspiro[3.3]heptan-2-yl, 1,6-diazaspiro[3.4]octan-6-yl, 2,6-diazaspiro[3.4]octan-2-yl, 2,6-diazaspiro[3.4]octan-6-yl, 1,7-diazaspiro[4.4]nonan-1-yl, 1,7-diazaspiro[4.4]nonan-7-yl, 1,7-diazaspiro[3.5]nonane- 7-yl, 2,6-diazaspiro[3.5]nonan-2-yl, 2,6-diazaspiro[3.5]nonan-6-yl, 1,7-diazaspiro[3.5]nonan-7-yl, 2,7-diazaspiro[3.5]nonan-2-yl, 2,7-diazaspiro[3.5]nonan-7-yl, 5,8-diazaspiro[3.5]nonan-8-yl, 2-oxa-5,8-diazaspiro[3.5]nonan-8-yl, 2,7-diaza Zaspiro[4.4]nonan-2-yl, 2,7-diazaspiro[4.5]decan-2-yl, 2,7-diazaspiro[4.5]decan-7-yl, 2,8-diazaspiro[4.5]decan-8-yl, 6,9-diazaspiro[4.5]decan-9-yl, 6-oxa-2,9-diazaspiro[4.5]decan-2-yl, 2,9-diazaspiro[5.5]undecan-9-yl, 4-azadispiro[2.1.2]undecan-2. 5 .3 3 ]decan-9-yl, and 7-azadispiro[5.1.5 8 .3 6 ]hexadecan-15-yl, and where available valences permit, three R b This includes compounds of formula (II) which are substituted with a substituent.

[0340] Another embodiment is where B is azetidin-1-yl, tetrahydrofuran-3-yl, pyrrolidin-1-yl, pyrrolidin-3-yl, piperidin-1-yl, piperidin-3-yl, piperidin-4-yl, piperidin-1-olate-4-yl, piperazin-1-yl, 1,4-diazepin-1-yl, 1,2-dihydropyridin-2-yl, 1,2-dihydropyridin-3-yl, 1,2-dihydropyridin-4-yl, 1,2-dihydropyridin-5-yl, 1,2-dihydropyridin-6-yl, 1,2,5,6-tetrahydropyridine-5-yl, 1,2,5,6-tetrahydropyridine ... -yl, 1,2,3,6-tetrahydropyridin-4-yl, hexahydrocyclopentapyrrol-2(1H)-yl, hexahydropyrrolo[3,2-b]pyrrol-1(2H)-yl, hexahydropyrrolo[3,4-b]pyrrol-1(2H)-yl, hexahydropyrrolo[3,4-c]pyrrol-1(1H)-yl, hexahydropyrrolo[3,4-c]pyrrol-2(1H)-yl, hexahydropyrrolo[3,4-c]pyrrol-5(1H)-yl, octahydro-5H-pyrrolo[3,2-c]pyridin-5-yl, octahydro-6H- Pyrrolo[3,4-b]pyridin-6-yl, hexahydropyrrolo[1,2-a]pyrazin-6(2H)-one, hexahydropyrrolo[1,2-a]pyrazin-2(1H)-yl, hexahydro-1H-cyclobuta[1.2-c:1,4-c′]dipyrrol-2(3H)-yl, octahydropyrrolo[1,2-a]pyrazin-2(1H)-yl, octahydro-2H-pyrido[1,2-a]pyrazin-2-yl, hexahydropyrrolo[3,4-b][1,4]oxazin-6(2H)-yl, 5-azaspiro[2.4]heptan-5-yl, 1- Azaspiro[3.3]heptan-2-yl, 4-azaspiro[2.5]octan-7-yl, 2-oxa-6-azaspiro[3.4]octan-6-yl, 3-azabicyclo[3.1.0]hexan-3-yl, 8-azabicyclo[3.2.1]octan-3-yl, 8-azabicyclo[3.2.1]oct-2-en-3-yl, 9-azabicyclo[3.3.1]nonan-3-yl, 2,5-diazabicyclo[2.2.1]heptan-2-yl, 1,4-diazabicyclo[3.1.1]heptan-4-yl, 3,6-diazabicyclo[3.2.0]heptan-3-yl, 3,6-diazabicyclo[3.2.0]heptan-6-yl, 2,5-diazabicyclo[2.2.2]octan-2-yl, 1,4-diazabicyclo[3.2.1]octan-4-yl, 3,8-diazabicyclo[3.2.1]octan-3-yl, 1,4-diazabicyclo[3.2.2]nonan-4-yl, 4,7-diazaspiro[2.5]octan-4-yl, 4,7-diazaspiro[2.5]octan-4-yl, 2,6-diazaspiro[3.3]heptan-2-yl, 1,6-diazaspiro[3.4]octan-6-yl, 2,6-diazaspiro[3.4]octan-2-yl, 2,6-diazaspiro[3.4]octan-6-yl, 1,7-diazaspiro[4.4]nonan-1-yl, 1,7-diazaspiro[4.4]nonan-7-yl, 1,7-diazaspiro[3.5]nonane- 7-yl, 2,6-diazaspiro[3.5]nonan-2-yl, 2,6-diazaspiro[3.5]nonan-6-yl, 1,7-diazaspiro[3.5]nonan-7-yl, 2,7-diazaspiro[3.5]nonan-2-yl, 2,7-diazaspiro[3.5]nonan-7-yl, 5,8-diazaspiro[3.5]nonan-8-yl, 2-oxa-5,8-diazaspiro[3.5]nonan-8-yl, 2,7-diaza Zaspiro[4.4]nonan-2-yl, 2,7-diazaspiro[4.5]decan-2-yl, 2,7-diazaspiro[4.5]decan-7-yl, 2,8-diazaspiro[4.5]decan-8-yl, 6,9-diazaspiro[4.5]decan-9-yl, 6-oxa-2,9-diazaspiro[4.5]decan-2-yl, 2,9-diazaspiro[5.5]undecan-9-yl, 4-azadispiro[2.1.2]undecan-2. 5 .3 3 ]decan-9-yl, and 7-azadispiro[5.1.5 8 .3 6 ]hexadecan-15-yl, and, where available valences permit, four R b This includes compounds of formula (II) which are substituted with a substituent.

[0341] Another embodiment is where B is azetidin-1-yl, tetrahydrofuran-3-yl, pyrrolidin-1-yl, pyrrolidin-3-yl, piperidin-1-yl, piperidin-3-yl, piperidin-4-yl, piperidin-1-olate-4-yl, piperazin-1-yl, 1,4-diazepin-1-yl, 1,2-dihydropyridin-2-yl, 1,2-dihydropyridin-3-yl, 1,2-dihydropyridin-4-yl, 1,2-dihydropyridin-5-yl, 1,2-dihydropyridin-6-yl, 1,2,5,6-tetrahydropyridine-5-yl, 1,2,5,6-tetrahydropyridine ... -yl, 1,2,3,6-tetrahydropyridin-4-yl, hexahydrocyclopentapyrrol-2(1H)-yl, hexahydropyrrolo[3,2-b]pyrrol-1(2H)-yl, hexahydropyrrolo[3,4-b]pyrrol-1(2H)-yl, hexahydropyrrolo[3,4-c]pyrrol-1(1H)-yl, hexahydropyrrolo[3,4-c]pyrrol-2(1H)-yl, hexahydropyrrolo[3,4-c]pyrrol-5(1H)-yl, octahydro-5H-pyrrolo[3,2-c]pyridin-5-yl, octahydro-6H- Pyrrolo[3,4-b]pyridin-6-yl, hexahydropyrrolo[1,2-a]pyrazin-6(2H)-one, hexahydropyrrolo[1,2-a]pyrazin-2(1H)-yl, hexahydro-1H-cyclobuta[1.2-c:1,4-c′]dipyrrol-2(3H)-yl, octahydropyrrolo[1,2-a]pyrazin-2(1H)-yl, octahydro-2H-pyrido[1,2-a]pyrazin-2-yl, hexahydropyrrolo[3,4-b][1,4]oxazin-6(2H)-yl, 5-azaspiro[2.4]heptan-5-yl, 1- Azaspiro[3.3]heptan-2-yl, 4-azaspiro[2.5]octan-7-yl, 2-oxa-6-azaspiro[3.4]octan-6-yl, 3-azabicyclo[3.1.0]hexan-3-yl, 8-azabicyclo[3.2.1]octan-3-yl, 8-azabicyclo[3.2.1]oct-2-en-3-yl, 9-azabicyclo[3.3.1]nonan-3-yl, 2,5-diazabicyclo[2.2.1]heptan-2-yl, 1,4-diazabicyclo[3.1.1]heptan-4-yl, 3,6-diazabicyclo[3.2.0]heptan-3-yl, 3,6-diazabicyclo[3.2.0]heptan-6-yl, 2,5-diazabicyclo[2.2.2]octan-2-yl, 1,4-diazabicyclo[3.2.1]octan-4-yl, 3,8-diazabicyclo[3.2.1]octan-3-yl, 1,4-diazabicyclo[3.2.2]nonan-4-yl, 4,7-diazaspiro[2.5]octan-4-yl, 4,7-diazaspiro[2.5]octan-4-yl, 2,6-diazaspiro[3.3]heptan-2-yl, 1,6-diazaspiro[3.4]octan-6-yl, 2,6-diazaspiro[3.4]octan-2-yl, 2,6-diazaspiro[3.4]octan-6-yl, 1,7-diazaspiro[4.4]nonan-1-yl, 1,7-diazaspiro[4.4]nonan-7-yl, 1,7-diazaspiro[3.5]nonane- 7-yl, 2,6-diazaspiro[3.5]nonan-2-yl, 2,6-diazaspiro[3.5]nonan-6-yl, 1,7-diazaspiro[3.5]nonan-7-yl, 2,7-diazaspiro[3.5]nonan-2-yl, 2,7-diazaspiro[3.5]nonan-7-yl, 5,8-diazaspiro[3.5]nonan-8-yl, 2-oxa-5,8-diazaspiro[3.5]nonan-8-yl, 2,7-diaza Zaspiro[4.4]nonan-2-yl, 2,7-diazaspiro[4.5]decan-2-yl, 2,7-diazaspiro[4.5]decan-7-yl, 2,8-diazaspiro[4.5]decan-8-yl, 6,9-diazaspiro[4.5]decan-9-yl, 6-oxa-2,9-diazaspiro[4.5]decan-2-yl, 2,9-diazaspiro[5.5]undecan-9-yl, 4-azadispiro[2.1.2]undecan-2. 5 .3 3 ]decan-9-yl, and 7-azadispiro[5.1.5 8 .3 6 ]hexadecan-15-yl, and where available valences permit, five R b This includes compounds of formula (II) which are substituted with a substituent.

[0342] Another embodiment is where B is heterocyclyl selected from pyrrolidin-1-yl, piperidin-4-yl, and piperazin-1-yl, and where available valences permit, 1, 2, 3, 4, or 5 R b This includes compounds of formula (II) which may be substituted with a substituent.

[0343] Another embodiment includes compounds of formula (II) where B is unsubstituted heterocyclyl selected from pyrrolidin-1-yl, piperidin-4-yl, and piperazin-1-yl.

[0344] Another embodiment is where B is heterocyclyl selected from pyrrolidin-1-yl, piperidin-4-yl, and piperazin-1-yl, and where available valences permit, one R b This includes compounds of formula (II) which are substituted with a substituent.

[0345] Another embodiment is where B is heterocyclyl selected from pyrrolidin-1-yl, piperidin-4-yl, and piperazin-1-yl, and where available valences permit, two R b This includes compounds of formula (II) which are substituted with a substituent.

[0346] Another embodiment is where B is heterocyclyl selected from pyrrolidin-1-yl, piperidin-4-yl, and piperazin-1-yl, and where available valences permit, three R b This includes compounds of formula (II) which are substituted with a substituent.

[0347] Another embodiment is where B is heterocyclyl selected from pyrrolidin-1-yl, piperidin-4-yl, and piperazin-1-yl, and where available valences permit, four R b This includes compounds of formula (II) which are substituted with a substituent.

[0348] Another embodiment is where B is heterocyclyl selected from pyrrolidin-1-yl, piperidin-4-yl, and piperazin-1-yl, and where available valences permit, five R b This includes compounds of formula (II) which are substituted with a substituent.

[0349] Another embodiment is where B is pyrrolidin-1-yl and, where available valences permit, one R b This includes compounds of formula (II) which are substituted with a substituent.

[0350] Another embodiment is where B is piperidin-4-yl and, where available valences allow, 4 or 5 R b This includes compounds of formula (II) which are substituted with a substituent.

[0351] Another embodiment is where B is piperidin-4-yl and, where available valences allow, four R b This includes compounds of formula (II) which are substituted with a substituent.

[0352] Another embodiment is where B is piperidin-4-yl and, where available valences allow, five R b This includes compounds of formula (II) which are substituted with a substituent.

[0353] Another embodiment is where B is piperazin-1-yl and, where available valences permit, one R b This includes compounds of formula (II) which are substituted with a substituent.

[0354] Another embodiment includes compounds of formula (II) where B is heterocyclyl containing at least one asymmetric carbon atom having the (R) configuration.

[0355] Another embodiment includes compounds of formula (II) where B is heterocyclyl containing at least one asymmetric carbon atom having an (S) configuration.

[0356] In one embodiment, R b But halogen, C1-4 Alkyl, Amino, C 1-4 Alkyl-amino, (C 1-4 Alkyl) 2 -amino, and C 3-6 cycloalkyl.

[0357] Another aspect is R b But halogen, C 1-4 Alkyl, C 1-4 Alkyl-amino, and C 3-6 cycloalkyl.

[0358] Another aspect is R b is a halogen selected from bromo, chloro, fluoro, and iodo.

[0359] Another aspect is R b is fluoro.

[0360] Another aspect is R b is selected from methyl, ethyl, propyl, isopropyl, butyl, and tert-butyl; 1-4 This includes compounds of formula (II) in which:

[0361] Another aspect is R b is selected from methyl and isopropyl 1-4 This includes compounds of formula (II) in which:

[0362] Another aspect is R b is methyl.

[0363] Another aspect is R b is isopropyl.

[0364] Another aspect is R b C 1-4 Includes compounds of formula (II) which are alkyl-amino.

[0365] Another aspect is R b But, C 1-4 Alkyl-amino, C 1-4 Includes compounds of formula (II) where alkyl is selected from methyl, ethyl, propyl, isopropyl, butyl, and tert-butyl.

[0366] Another aspect is R b is tert-butylamino.

[0367] Another aspect is R b is selected from cyclopropyl, cyclobutyl, cyclopentyl, and cyclohexyl; 3-6 This includes compounds of formula (II) which are cycloalkyl.

[0368] Another aspect is R b is cyclopropyl.

[0369] In one embodiment, R 1 Heteroaryl, heterocyclyl, phenyl, heteroaryl-C 1-4 Alkyl, Heteroaryl-C 2-4 Alkenyl, Heteroaryl-amino, and Heteroaryl-C 1-4 alkyl-amino, Heteroaryl is a 3-7 membered monocyclic or 6-10 membered bicyclic ring system having 1, 2, 3, or 4 heteroatom ring members independently selected from N, O, or S; Heterocyclyl is a saturated or partially unsaturated 3- to 7-membered monocyclic, 6- to 10-membered bicyclic or 13- to 16-membered polycyclic ring system having 1, 2 or 3 heteroatom ring members independently selected from N, O or S; Each example of phenyl, heteroaryl, or heterocyclyl may have one or two R 1a It may be substituted with a substituent.

[0370] Another aspect is R 1 Heteroaryl, heterocyclyl, phenyl, heteroaryl-C 1-4 Alkyl, Heteroaryl-C 2-4 Alkenyl, Heteroaryl-amino, and Heteroaryl-C 1-4 alkyl-amino, Heteroaryl is a 3-7 membered monocyclic or 6-10 membered bicyclic ring system having 1, 2, 3, or 4 heteroatom ring members independently selected from N, O, or S; Heterocyclyl is a saturated or partially unsaturated 3- to 7-membered monocyclic, 6- to 10-membered bicyclic or 13- to 16-membered polycyclic ring system having 1, 2 or 3 heteroatom ring members independently selected from N, O or S; Each instance of phenyl, heteroaryl or heterocyclyl is unsubstituted.

[0371] Another aspect is R 1 Heteroaryl, heterocyclyl, phenyl, heteroaryl-C 1-4 Alkyl, Heteroaryl-C 2-4 Alkenyl, Heteroaryl-amino, and Heteroaryl-C 1-4 alkyl-amino, Heteroaryl is a 3-7 membered monocyclic or 6-10 membered bicyclic ring system having 1, 2, 3, or 4 heteroatom ring members independently selected from N, O, or S; Heterocyclyl is a saturated or partially unsaturated 3- to 7-membered monocyclic, 6- to 10-membered bicyclic or 13- to 16-membered polycyclic ring system having 1, 2 or 3 heteroatom ring members independently selected from N, O or S; Each example of phenyl, heteroaryl, or heterocyclyl may be substituted with one R 1a It is substituted with a substituent.

[0372] Another aspect is R 1 Heteroaryl, heterocyclyl, phenyl, heteroaryl-C1-4 Alkyl, Heteroaryl-C 2-4 Alkenyl, Heteroaryl-amino, and Heteroaryl-C 1-4 alkyl-amino, Heteroaryl is a 3-7 membered monocyclic or 6-10 membered bicyclic ring system having 1, 2, 3, or 4 heteroatom ring members independently selected from N, O, or S; Heterocyclyl is a saturated or partially unsaturated 3- to 7-membered monocyclic, 6- to 10-membered bicyclic or 13- to 16-membered polycyclic ring system having 1, 2 or 3 heteroatom ring members independently selected from N, O or S; Each example of phenyl, heteroaryl, or heterocyclyl may have two R 1a It is substituted with a substituent.

[0373] Another aspect is R 1 is selected from heteroaryl, and heteroaryl-amino; Heteroaryl is a 3-7 membered monocyclic or 6-10 membered bicyclic ring system having 1, 2, 3, or 4 heteroatom ring members independently selected from N, O, or S, and heteroaryl may contain, where available valences permit, one or two R 1a It may be substituted with a substituent.

[0374] Another aspect is R 1 is selected from heteroaryl, and heteroaryl-amino; Heteroaryl is a 3-7 membered monocyclic or 6-10 membered bicyclic ring system having 1, 2, 3, or 4 heteroatom ring members independently selected from N, O, or S, and heteroaryl is unsubstituted.

[0375] Another aspect is R 1 is selected from heteroaryl, and heteroaryl-amino; Heteroaryl is a 3-7 membered monocyclic or 6-10 membered bicyclic ring system having 1, 2, 3, or 4 heteroatom ring members independently selected from N, O, or S, and heteroaryl may contain, where available valences permit, one R 1a It is substituted with a substituent.

[0376] Another aspect is R 1 is selected from heteroaryl, and heteroaryl-amino; Heteroaryl is a 3-7 membered monocyclic or 6-10 membered bicyclic ring system having 1, 2, 3, or 4 heteroatom ring members independently selected from N, O, or S, and heteroaryl may contain, where available valences permit, two R 1a It is substituted with a substituent.

[0377] Another aspect is R 1thienyl, 1H-pyrazolyl, 1H-imidazolyl, 1,3-thiazolyl, oxazolyl, 1,2,4-oxadiazolyl, 1,3,4-oxadiazolyl, 1,2,4-thiadiazolyl, 1H-1,2,3-triazolyl, 2H-1,2,3-triazolyl, 1H-1,2,4-triazolyl, 1H-tetrazolyl, 2H-tetrazolyl, pyridinyl, pyridin-2(1H)-one-yl, pyrazinyl, pyrimidinyl, pyrimidin-4(3H)-one-yl, pyridazinyl, pyridazin-3(2H)-one-yl, 1,2,4-triazinyl, 1, 3,5-Triazinyl, 1H-Indolyl, 1H-Indazolyl, 2H-Indazolyl, Indolizinyl, Benzofuranyl, Benzothienyl, 1H-Benzimidazolyl, 1,3-Benzoxazolyl, 1,3-Benzothiazolyl, 1,3-Benzodioxolyl, 1,2,3-Benzotriazolyl, 9H-Purinyl, Furo[3,2-b]pyridinyl, Furo[3,2-c]pyridinyl, Furo[2,3-c]pyridinyl, 1,3-Oxazolo[5,4-b]pyridinyl, Thieno[3,2-c]pyridinyl, Thieno[2,3-d]pyrimidinyl, 1H-Pyrrolo[ 2,3-b]pyridinyl, 1H-pyrrolo[2,3-c]pyridinyl, pyrrolo[1,2-a]pyrimidinyl, pyrrolo[1,2-a]pyrazinyl, pyrrolo[1,2-b]pyridazinyl, pyrazolo[1,5-a]pyridinyl, pyrazolo[1,5-a]pyrimidinyl, pyrazolo[1,5-a]pyrazinyl, 1H-pyrazolo[3,4-b]pyridinyl, 1H-pyrazolo[3,4-b]pyrazinyl, 1H-pyrazolo[3,4-c]pyridinyl, 1H-pyrazolo[4,3-b]pyridinyl, 1H-pyrazolo[4,3-d]pyrimidinyl, 2H-pyrazolo[4,3-b]pyridinyl Lysinyl, 2H-pyrazolo[4,3-c]pyridinyl, 5H-pyrrolo[2,3-b]pyrazinyl, imidazo[1,2-a]pyridinyl, imidazo[1,2-a]pyrazinyl, imidazo[1,2-a]pyrimidinyl, imidazo[1,2-b]pyridazinyl, imidazo[1,2-c]pyrimidinyl, 1H-imidazo[4,5-b]pyridinyl, 3H-imidazo[4,5-b]pyridinyl, imidazo[2,1-b][1,3]thiazolyl, imidazo[2,1-b][1,3,4]thiadiazolyl, [1,3]oxazolo[4,5-b]pyridinyl, [1,2,3]triazolo[1,5-a]pyridinyl, 1H-[1,2,3]triazolo[4,5-b]pyridinyl, 2H-[1,2,3]triazolo[4,5-b]pyridinyl, 3H-[1,2,3]triazolo[4,5-b]pyridinyl, [1,2,4]triazolo[1,5-a]pyridinyl, [1,2,4]triazolo[1,5-a]pyridinyl, [1,2,4]triazolo[1,5-a]pyrazinyl, [1,2,4]triazolo[4,3-a]pyridinyl, tetrazolo[1,5-a]pyridinyl, tetrazolo[1,5-b]pyridazinyl, quinolinyl, isoquinolinyl, and quinoxalinyl, where available valences permit, one or two R, 1a This includes compounds of formula (II) which may be substituted with a substituent.

[0378] Another aspect is R 1thienyl, 1H-pyrazolyl, 1H-imidazolyl, 1,3-thiazolyl, oxazolyl, 1,2,4-oxadiazolyl, 1,3,4-oxadiazolyl, 1,2,4-thiadiazolyl, 1H-1,2,3-triazolyl, 2H-1,2,3-triazolyl, 1H-1,2,4-triazolyl, 1H-tetrazolyl, 2H-tetrazolyl, pyridinyl, pyridin-2(1H)-one-yl, pyrazinyl, pyrimidinyl, pyrimidin-4(3H)-one-yl, pyridazinyl, pyridazin-3(2H)-one-yl, 1,2,4-triazinyl, 1, 3,5-Triazinyl, 1H-Indolyl, 1H-Indazolyl, 2H-Indazolyl, Indolizinyl, Benzofuranyl, Benzothienyl, 1H-Benzimidazolyl, 1,3-Benzoxazolyl, 1,3-Benzothiazolyl, 1,3-Benzodioxolyl, 1,2,3-Benzotriazolyl, 9H-Purinyl, Furo[3,2-b]pyridinyl, Furo[3,2-c]pyridinyl, Furo[2,3-c]pyridinyl, 1,3-Oxazolo[5,4-b]pyridinyl, Thieno[3,2-c]pyridinyl, Thieno[2,3-d]pyrimidinyl, 1H-Pyrrolo[ 2,3-b]pyridinyl, 1H-pyrrolo[2,3-c]pyridinyl, pyrrolo[1,2-a]pyrimidinyl, pyrrolo[1,2-a]pyrazinyl, pyrrolo[1,2-b]pyridazinyl, pyrazolo[1,5-a]pyridinyl, pyrazolo[1,5-a]pyrimidinyl, pyrazolo[1,5-a]pyrazinyl, 1H-pyrazolo[3,4-b]pyridinyl, 1H-pyrazolo[3,4-b]pyrazinyl, 1H-pyrazolo[3,4-c]pyridinyl, 1H-pyrazolo[4,3-b]pyridinyl, 1H-pyrazolo[4,3-d]pyrimidinyl, 2H-pyrazolo[4,3-b]pyridinyl Lysinyl, 2H-pyrazolo[4,3-c]pyridinyl, 5H-pyrrolo[2,3-b]pyrazinyl, imidazo[1,2-a]pyridinyl, imidazo[1,2-a]pyrazinyl, imidazo[1,2-a]pyrimidinyl, imidazo[1,2-b]pyridazinyl, imidazo[1,2-c]pyrimidinyl, 1H-imidazo[4,5-b]pyridinyl, 3H-imidazo[4,5-b]pyridinyl, imidazo[2,1-b][1,3]thiazolyl, imidazo[2,1-b][1,3,4]thiadiazolyl, [1,3]oxazolo[4,5-b]pyridinyl, [1,2,3]triazolo[1,5-a]pyridinyl, 1H-[1,2,3]triazolo[4,5-b]pyridinyl, 2H-[1,2,3]triazolo[4,5-b]pyridinyl, 3H-[1,2,3]triazolo[4,5-b]pyridinyl, [1,2,4]triazolo[1,5-a]pyridinyl, [1,2,4]triazolo[1,5-a]pyridinyl, [1,2,4]triazolo[4,3-a]pyridinyl, tetrazolo[1,5-a]pyridinyl, tetrazolo[1,5-b]pyridazinyl, quinolinyl, isoquinolinyl, and quinoxalinyl.

[0379] Another aspect is R 1thienyl, 1H-pyrazolyl, 1H-imidazolyl, 1,3-thiazolyl, oxazolyl, 1,2,4-oxadiazolyl, 1,3,4-oxadiazolyl, 1,2,4-thiadiazolyl, 1H-1,2,3-triazolyl, 2H-1,2,3-triazolyl, 1H-1,2,4-triazolyl, 1H-tetrazolyl, 2H-tetrazolyl, pyridinyl, pyridin-2(1H)-one-yl, pyrazinyl, pyrimidinyl, pyrimidin-4(3H)-one-yl, pyridazinyl, pyridazin-3(2H)-one-yl, 1,2,4-triazinyl, 1, 3,5-Triazinyl, 1H-Indolyl, 1H-Indazolyl, 2H-Indazolyl, Indolizinyl, Benzofuranyl, Benzothienyl, 1H-Benzimidazolyl, 1,3-Benzoxazolyl, 1,3-Benzothiazolyl, 1,3-Benzodioxolyl, 1,2,3-Benzotriazolyl, 9H-Purinyl, Furo[3,2-b]pyridinyl, Furo[3,2-c]pyridinyl, Furo[2,3-c]pyridinyl, 1,3-Oxazolo[5,4-b]pyridinyl, Thieno[3,2-c]pyridinyl, Thieno[2,3-d]pyrimidinyl, 1H-Pyrrolo[ 2,3-b]pyridinyl, 1H-pyrrolo[2,3-c]pyridinyl, pyrrolo[1,2-a]pyrimidinyl, pyrrolo[1,2-a]pyrazinyl, pyrrolo[1,2-b]pyridazinyl, pyrazolo[1,5-a]pyridinyl, pyrazolo[1,5-a]pyrimidinyl, pyrazolo[1,5-a]pyrazinyl, 1H-pyrazolo[3,4-b]pyridinyl, 1H-pyrazolo[3,4-b]pyrazinyl, 1H-pyrazolo[3,4-c]pyridinyl, 1H-pyrazolo[4,3-b]pyridinyl, 1H-pyrazolo[4,3-d]pyrimidinyl, 2H-pyrazolo[4,3-b]pyridinyl Lysinyl, 2H-pyrazolo[4,3-c]pyridinyl, 5H-pyrrolo[2,3-b]pyrazinyl, imidazo[1,2-a]pyridinyl, imidazo[1,2-a]pyrazinyl, imidazo[1,2-a]pyrimidinyl, imidazo[1,2-b]pyridazinyl, imidazo[1,2-c]pyrimidinyl, 1H-imidazo[4,5-b]pyridinyl, 3H-imidazo[4,5-b]pyridinyl, imidazo[2,1-b][1,3]thiazolyl, imidazo[2,1-b][1,3,4]thiadiazolyl, [1,3]oxazolo[4,5-b]pyridinyl, [1,2,3]triazolo[1,5-a]pyridinyl, 1H-[1,2,3]triazolo[4,5-b]pyridinyl, 2H-[1,2,3]triazolo[4,5-b]pyridinyl, 3H-[1,2,3]triazolo[4,5-b]pyridinyl, [1,2,4]triazolo[1,5-a]pyridinyl, [1,2,4]triazolo[1,5-a]pyridinyl, [1,2,4]triazolo[1,5-a]pyridazinyl, [1,2,4]triazolo[4,3-a]pyridinyl, tetrazolo[1,5-a]pyridinyl, tetrazolo[1,5-b]pyridazinyl, quinolinyl, isoquinolinyl, and quinoxalinyl, where available valences permit, one R, 1a This includes compounds of formula (II) which are substituted with a substituent.

[0380] Another aspect is R 1thienyl, 1H-pyrazolyl, 1H-imidazolyl, 1,3-thiazolyl, oxazolyl, 1,2,4-oxadiazolyl, 1,3,4-oxadiazolyl, 1,2,4-thiadiazolyl, 1H-1,2,3-triazolyl, 2H-1,2,3-triazolyl, 1H-1,2,4-triazolyl, 1H-tetrazolyl, 2H-tetrazolyl, pyridinyl, pyridin-2(1H)-one-yl, pyrazinyl, pyrimidinyl, pyrimidin-4(3H)-one-yl, pyridazinyl, pyridazin-3(2H)-one-yl, 1,2,4-triazinyl, 1, 3,5-Triazinyl, 1H-Indolyl, 1H-Indazolyl, 2H-Indazolyl, Indolizinyl, Benzofuranyl, Benzothienyl, 1H-Benzimidazolyl, 1,3-Benzoxazolyl, 1,3-Benzothiazolyl, 1,3-Benzodioxolyl, 1,2,3-Benzotriazolyl, 9H-Purinyl, Furo[3,2-b]pyridinyl, Furo[3,2-c]pyridinyl, Furo[2,3-c]pyridinyl, 1,3-Oxazolo[5,4-b]pyridinyl, Thieno[3,2-c]pyridinyl, Thieno[2,3-d]pyrimidinyl, 1H-Pyrrolo[ 2,3-b]pyridinyl, 1H-pyrrolo[2,3-c]pyridinyl, pyrrolo[1,2-a]pyrimidinyl, pyrrolo[1,2-a]pyrazinyl, pyrrolo[1,2-b]pyridazinyl, pyrazolo[1,5-a]pyridinyl, pyrazolo[1,5-a]pyrimidinyl, pyrazolo[1,5-a]pyrazinyl, 1H-pyrazolo[3,4-b]pyridinyl, 1H-pyrazolo[3,4-b]pyrazinyl, 1H-pyrazolo[3,4-c]pyridinyl, 1H-pyrazolo[4,3-b]pyridinyl, 1H-pyrazolo[4,3-d]pyrimidinyl, 2H-pyrazolo[4,3-b]pyridinyl Lysinyl, 2H-pyrazolo[4,3-c]pyridinyl, 5H-pyrrolo[2,3-b]pyrazinyl, imidazo[1,2-a]pyridinyl, imidazo[1,2-a]pyrazinyl, imidazo[1,2-a]pyrimidinyl, imidazo[1,2-b]pyridazinyl, imidazo[1,2-c]pyrimidinyl, 1H-imidazo[4,5-b]pyridinyl, 3H-imidazo[4,5-b]pyridinyl, imidazo[2,1-b][1,3]thiazolyl, imidazo[2,1-b][1,3,4]thiadiazolyl, [1,3]oxazolo[4,5-b]pyridinyl, [1,2,3]triazolo[1,5-a]pyridinyl, 1H-[1,2,3]triazolo[4,5-b]pyridinyl, 2H-[1,2,3]triazolo[4,5-b]pyridinyl, 3H-[1,2,3]triazolo[4,5-b]pyridinyl, [1,2,4]triazolo[1,5-a]pyridinyl, [1,2,4]triazolo[1,5-a]pyridinyl, [1,2,4]triazolo[1,5-a]pyrazinyl, [1,2,4]triazolo[4,3-a]pyridinyl, tetrazolo[1,5-a]pyridinyl, tetrazolo[1,5-b]pyridazinyl, quinolinyl, isoquinolinyl, and quinoxalinyl, where available valences permit, two R, 1a This includes compounds of formula (II) which are substituted with a substituent.

[0381] Another aspect is R 1 is heteroaryl selected from 1H-pyrazolyl, 2H-1,2,3-triazolyl, 2H-indazolyl, imidazo[1,2-a]pyridinyl, imidazo[1,2-b]pyridazinyl, and 2H-[1,2,3]triazolo[4,5-b]pyridinyl, where available valences permit, one or two R 1a This includes compounds of formula (II) which may be substituted with a substituent.

[0382] Another aspect is R 1 is an unsubstituted heteroaryl selected from 1H-pyrazolyl, 2H-1,2,3-triazolyl, 2H-indazolyl, imidazo[1,2-a]pyridinyl, imidazo[1,2-b]pyridazinyl, and 2H-[1,2,3]triazolo[4,5-b]pyridinyl.

[0383] Another aspect is R 1 is heteroaryl selected from 1H-pyrazolyl, 2H-1,2,3-triazolyl, 2H-indazolyl, imidazo[1,2-a]pyridinyl, imidazo[1,2-b]pyridazinyl, and 2H-[1,2,3]triazolo[4,5-b]pyridinyl, and where permitted by available valences, one R 1a This includes compounds of formula (II) which are substituted with a substituent.

[0384] Another aspect is R 1 is a heteroaryl selected from 1H-pyrazolyl, 2H-1,2,3-triazolyl, 2H-indazolyl, imidazo[1,2-a]pyridinyl, imidazo[1,2-b]pyridazinyl, and 2H-[1,2,3]triazolo[4,5-b]pyridinyl, where available valences permit, two R 1a This includes compounds of formula (II) which are substituted with a substituent.

[0385] Another aspect is R 1Thien-2-yl, thien-3-yl, 1H-pyrazol-1-yl, 1H-pyrazol-3-yl, 1H-pyrazol-4-yl, 1H-pyrazol-5-yl, 1H-imidazol-1-yl, 1H-imidazol-4-yl, 1,3-thiazol-2-yl, 1,3-thiazol-5-yl, 1,3-oxazol-2-yl, 1,3-oxazol-4-yl, 1,3-oxazol-5-yl, 1,2,4-oxadiazol-3-yl, 1,3,4-oxadiazol-2-yl, 1,2,4-thiadiazol-5-yl, 1H-1, 2,3-Triazol-1-yl, 1H-1,2,3-triazol-4-yl, 1H-1,2,3-triazol-5-yl, 2H-1,2,3-triazol-2-yl, 2H-1,2,3-triazol-4-yl, 1H-1,2,4-triazol-1-yl, 1H-1,2,4-triazol-3-yl, 1H-1,2,4-triazol-5-yl, 1H-tetrazol-1-yl, 1H-tetrazol-5-yl, 2H-tetrazol-2-yl, 2H-tetrazol-5-yl, pyridin-2-yl, pyridin-3-yl, pyridin- 4-yl, pyridin-2(1H)-one-4-yl, pyridin-2(1H)-one-5-yl, pyridin-2(1H)-one-6-yl, pyrazin-2-yl, pyrazin-3-yl, pyrimidin-2-yl, pyrimidin-4-yl, pyrimidin-5-yl, pyrimidin-4(3H)-one-6-yl, pyridazin-3-yl, pyridazin-4-yl, pyridazin-3(2H)-one-5-yl, 1,2,4-triazin-3-yl, 1,3,5-triazin-2-yl, 1H-indol-3-yl, 1H-indol-4-yl, 1H-indol- 5-yl, 1H-indol-6-yl, 1H-indazol-5-yl, 1H-indazol-6-yl, 2H-indazol-4-yl, 2H-indazol-5-yl, 2H-indazol-6-yl, indolizin-2-yl, benzofuran-2-yl, benzofuran-5-yl, benzothien-2-yl, benzothien-3-yl, 1H-benzimidazol-2-yl, 1H-benzimidazol-5-yl, 1H-benzimidazol-6-yl, 1,3-benzoxazol-2-yl, 1,3-benzoxazol-5-yl, 1,3-Benzoxazol-6-yl, 1,3-benzothiazol-2-yl, 1,3-benzothiazol-5-yl, 1,3-benzothiazol-6-yl, 1,3-benzodioxol-5-yl, 1,2,3-benzotriazol-5-yl, 9H-purin-8-yl, furo[3,2-b]pyridin-2-yl, furo[3,2-c]pyridin-2-yl, furo[2,3-c]pyridin-2-yl, 1,3-oxazolo[5,4-b]pyridin-5-yl, thieno[3,2-c]pyridin-2-yl, thieno[2,3-d]pyrimidin-6-yl pyrrolo[2,3-b]pyridin-5-yl, 1H-pyrrolo[2,3-c]pyridin-4-yl, pyrrolo[1,2-a]pyrimidin-7-yl, pyrrolo[1,2-a]pyrazin-7-yl, pyrrolo[1,2-b]pyridazin-2-yl, pyrazolo[1,5-a]pyridin-2-yl, pyrazolo[1,5-a]pyridin-5-yl, pyrazolo[1,5-a]pyrazin-2-yl, pyrazolo[1,5-a]pyrimidin-2-yl, pyrazolo[1,5-a]pyrimidin-5-yl, 1H-pyrazolo[3,4-b]pyraz ... 1H-pyrazolo[3,4-b]pyridin-5-yl, 1H-pyrazolo[3,4-b]pyridin-6-yl, 1H-pyrazolo[3,4-c]pyridin-1-yl, 1H-pyrazolo[3,4-c]pyridin-5-yl, 1H-pyrazolo[4,3-b]pyridin-5-yl, 1H-pyrazolo[4,3-b]pyridin-6-yl, 1H-pyrazolo[4,3-d]pyrimidin-5-yl, 2H-pyrazolo[4,3-b]pyridin-5-yl, 2H-pyrazolo[4,3-c]pyridin-5-yl, 5H-pyrrolo[2,3-b]pyrazin-2-yl, imidazo[1,2-a ]pyridin-2-yl, imidazo[1,2-a]pyridin-6-yl, imidazo[1,2-a]pyrazin-2-yl, imidazo[1,2-a]pyrazin-6-yl, imidazo[1,2-a]pyrimidin-2-yl, imidazo[1,2-a]pyrimidin-6-yl, imidazo[1,2-b]pyridazin-2-yl, imidazo[1,2-b]pyridazin-6-yl, imidazo[1,2-c]pyrimidin-2-yl, 1H-imidazo[4,5-b]pyridin-5-yl, 3H-imidazo[4,5-b]pyridin-5-yl, imidazo[2,1-b][1,3]thiazol-6-yl, imidazo[2,1-b][1,3,4]thiadiazol-6-yl, [1,3]oxazolo[4,5-b]pyridin-2-yl, [1,2,3]triazolo[1,5-a]pyridin-5-yl, [1,2,3]triazolo[1,5-a]pyridin-6-yl, 1H-[1,2,3]triazolo[4,5-b]pyridin-5-yl, 2H-[1,2,3]triazolo[4,5-b]pyridin-6-yl, 3H-[1,2,3]triazolo[4,5-b]pyridin-5-yl, [1,2,4]triazolo[1,5-a]pyridin-2-yl, [1,2,4]triazolo[1,5-a]pyridin-6-yl, [1,2,4]thiazolo[1,5-a]pyridin-6-yl heteroaryl selected from riazolo[1,5-a]pyridin-7-yl, [1,2,4]triazolo[1,5-a]pyrazin-2-yl, [1,2,4]triazolo[1,5-a]pyrazin-5-yl, [1,2,4]triazolo[1,5-a]pyrazin-6-yl, [1,2,4]triazolo[4,3-a]pyridin-6-yl, [1,2,4]triazolo[4,3-a]pyridin-7-yl, tetrazolo[1,5-a]pyridin-7-yl, tetrazolo[1,5-b]pyridazin-7-yl, quinolin-6-yl, isoquinolin-6-yl, and quinoxalin-2-yl, where available valences permit, one or two R, 1a This includes compounds of formula (II) which may be substituted with a substituent.

[0386] Another aspect is R 1Thien-2-yl, thien-3-yl, 1H-pyrazol-1-yl, 1H-pyrazol-3-yl, 1H-pyrazol-4-yl, 1H-pyrazol-5-yl, 1H-imidazol-1-yl, 1H-imidazol-4-yl, 1,3-thiazol-2-yl, 1,3-thiazol-5-yl, 1,3-oxazol-2-yl, 1,3-oxazol-4-yl, 1,3-oxazol-5-yl, 1,2,4-oxadiazol-3-yl, 1,3,4-oxadiazol-2-yl, 1,2,4-thiadiazol-5-yl, 1H-1, 2,3-Triazol-1-yl, 1H-1,2,3-triazol-4-yl, 1H-1,2,3-triazol-5-yl, 2H-1,2,3-triazol-2-yl, 2H-1,2,3-triazol-4-yl, 1H-1,2,4-triazol-1-yl, 1H-1,2,4-triazol-3-yl, 1H-1,2,4-triazol-5-yl, 1H-tetrazol-1-yl, 1H-tetrazol-5-yl, 2H-tetrazol-2-yl, 2H-tetrazol-5-yl, pyridin-2-yl, pyridin-3-yl, pyridin- 4-yl, pyridin-2(1H)-one-4-yl, pyridin-2(1H)-one-5-yl, pyridin-2(1H)-one-6-yl, pyrazin-2-yl, pyrazin-3-yl, pyrimidin-2-yl, pyrimidin-4-yl, pyrimidin-5-yl, pyrimidin-4(3H)-one-6-yl, pyridazin-3-yl, pyridazin-4-yl, pyridazin-3(2H)-one-5-yl, 1,2,4-triazin-3-yl, 1,3,5-triazin-2-yl, 1H-indol-3-yl, 1H-indol-4-yl, 1H-indol- 5-yl, 1H-indol-6-yl, 1H-indazol-5-yl, 1H-indazol-6-yl, 2H-indazol-4-yl, 2H-indazol-5-yl, 2H-indazol-6-yl, indolizin-2-yl, benzofuran-2-yl, benzofuran-5-yl, benzothien-2-yl, benzothien-3-yl, 1H-benzimidazol-2-yl, 1H-benzimidazol-5-yl, 1H-benzimidazol-6-yl, 1,3-benzoxazol-2-yl, 1,3-benzoxazol-5-yl, 1,3-Benzoxazol-6-yl, 1,3-benzothiazol-2-yl, 1,3-benzothiazol-5-yl, 1,3-benzothiazol-6-yl, 1,3-benzodioxol-5-yl, 1,2,3-benzotriazol-5-yl, 9H-purin-8-yl, furo[3,2-b]pyridin-2-yl, furo[3,2-c]pyridin-2-yl, furo[2,3-c]pyridin-2-yl, 1,3-oxazolo[5,4-b]pyridin-5-yl, thieno[3,2-c]pyridin-2-yl, thieno[2,3-d]pyrimidin-6-yl pyrrolo[2,3-b]pyridin-5-yl, 1H-pyrrolo[2,3-c]pyridin-4-yl, pyrrolo[1,2-a]pyrimidin-7-yl, pyrrolo[1,2-a]pyrazin-7-yl, pyrrolo[1,2-b]pyridazin-2-yl, pyrazolo[1,5-a]pyridin-2-yl, pyrazolo[1,5-a]pyridin-5-yl, pyrazolo[1,5-a]pyrazin-2-yl, pyrazolo[1,5-a]pyrimidin-2-yl, pyrazolo[1,5-a]pyrimidin-5-yl, 1H-pyrazolo[3,4-b]pyraz ... 1H-pyrazolo[3,4-b]pyridin-5-yl, 1H-pyrazolo[3,4-b]pyridin-6-yl, 1H-pyrazolo[3,4-c]pyridin-1-yl, 1H-pyrazolo[3,4-c]pyridin-5-yl, 1H-pyrazolo[4,3-b]pyridin-5-yl, 1H-pyrazolo[4,3-b]pyridin-6-yl, 1H-pyrazolo[4,3-d]pyrimidin-5-yl, 2H-pyrazolo[4,3-b]pyridin-5-yl, 2H-pyrazolo[4,3-c]pyridin-5-yl, 5H-pyrrolo[2,3-b]pyrazin-2-yl, imidazo[1,2-a ]pyridin-2-yl, imidazo[1,2-a]pyridin-6-yl, imidazo[1,2-a]pyrazin-2-yl, imidazo[1,2-a]pyrazin-6-yl, imidazo[1,2-a]pyrimidin-2-yl, imidazo[1,2-a]pyrimidin-6-yl, imidazo[1,2-b]pyridazin-2-yl, imidazo[1,2-b]pyridazin-6-yl, imidazo[1,2-c]pyrimidin-2-yl, 1H-imidazo[4,5-b]pyridin-5-yl, 3H-imidazo[4,5-b]pyridin-5-yl, imidazo[2,1-b][1,3]thiazol-6-yl, imidazo[2,1-b][1,3,4]thiadiazol-6-yl, [1,3]oxazolo[4,5-b]pyridin-2-yl, [1,2,3]triazolo[1,5-a]pyridin-5-yl, [1,2,3]triazolo[1,5-a]pyridin-6-yl, 1H-[1,2,3]triazolo[4,5-b]pyridin-5-yl, 2H-[1,2,3]triazolo[4,5-b]pyridin-6-yl, 3H-[1,2,3]triazolo[4,5-b]pyridin-5-yl, [1,2,4]triazolo[1,5-a]pyridin-2-yl, [1,2,4]triazolo[1,5-a]pyridin-6-yl, [1, The compound of formula (II) is an unsubstituted heteroaryl selected from [1,2,4]triazolo[1,5-a]pyridin-7-yl, [1,2,4]triazolo[1,5-a]pyrazin-2-yl, [1,2,4]triazolo[1,5-a]pyrazin-5-yl, [1,2,4]triazolo[1,5-a]pyrazin-6-yl, [1,2,4]triazolo[4,3-a]pyridin-6-yl, [1,2,4]triazolo[4,3-a]pyridin-7-yl, tetrazolo[1,5-a]pyridin-7-yl, tetrazolo[1,5-b]pyridazin-7-yl, quinolin-6-yl, isoquinolin-6-yl, and quinoxalin-2-yl.

[0387] Another aspect is R 1Thien-2-yl, thien-3-yl, 1H-pyrazol-1-yl, 1H-pyrazol-3-yl, 1H-pyrazol-4-yl, 1H-pyrazol-5-yl, 1H-imidazol-1-yl, 1H-imidazol-4-yl, 1,3-thiazol-2-yl, 1,3-thiazol-5-yl, 1,3-oxazol-2-yl, 1,3-oxazol-4-yl, 1,3-oxazol-5-yl, 1,2,4-oxadiazol-3-yl, 1,3,4-oxadiazol-2-yl, 1,2,4-thiadiazol-5-yl, 1H-1, 2,3-Triazol-1-yl, 1H-1,2,3-triazol-4-yl, 1H-1,2,3-triazol-5-yl, 2H-1,2,3-triazol-2-yl, 2H-1,2,3-triazol-4-yl, 1H-1,2,4-triazol-1-yl, 1H-1,2,4-triazol-3-yl, 1H-1,2,4-triazol-5-yl, 1H-tetrazol-1-yl, 1H-tetrazol-5-yl, 2H-tetrazol-2-yl, 2H-tetrazol-5-yl, pyridin-2-yl, pyridin-3-yl, pyridin- 4-yl, pyridin-2(1H)-one-4-yl, pyridin-2(1H)-one-5-yl, pyridin-2(1H)-one-6-yl, pyrazin-2-yl, pyrazin-3-yl, pyrimidin-2-yl, pyrimidin-4-yl, pyrimidin-5-yl, pyrimidin-4(3H)-one-6-yl, pyridazin-3-yl, pyridazin-4-yl, pyridazin-3(2H)-one-5-yl, 1,2,4-triazin-3-yl, 1,3,5-triazin-2-yl, 1H-indol-3-yl, 1H-indol-4-yl, 1H-indol- 5-yl, 1H-indol-6-yl, 1H-indazol-5-yl, 1H-indazol-6-yl, 2H-indazol-4-yl, 2H-indazol-5-yl, 2H-indazol-6-yl, indolizin-2-yl, benzofuran-2-yl, benzofuran-5-yl, benzothien-2-yl, benzothien-3-yl, 1H-benzimidazol-2-yl, 1H-benzimidazol-5-yl, 1H-benzimidazol-6-yl, 1,3-benzoxazol-2-yl, 1,3-benzoxazol-5-yl, 1,3-Benzoxazol-6-yl, 1,3-benzothiazol-2-yl, 1,3-benzothiazol-5-yl, 1,3-benzothiazol-6-yl, 1,3-benzodioxol-5-yl, 1,2,3-benzotriazol-5-yl, 9H-purin-8-yl, furo[3,2-b]pyridin-2-yl, furo[3,2-c]pyridin-2-yl, furo[2,3-c]pyridin-2-yl, 1,3-oxazolo[5,4-b]pyridin-5-yl, thieno[3,2-c]pyridin-2-yl, thieno[2,3-d]pyrimidin-6-yl pyrrolo[2,3-b]pyridin-5-yl, 1H-pyrrolo[2,3-c]pyridin-4-yl, pyrrolo[1,2-a]pyrimidin-7-yl, pyrrolo[1,2-a]pyrazin-7-yl, pyrrolo[1,2-b]pyridazin-2-yl, pyrazolo[1,5-a]pyridin-2-yl, pyrazolo[1,5-a]pyridin-5-yl, pyrazolo[1,5-a]pyrazin-2-yl, pyrazolo[1,5-a]pyrimidin-2-yl, pyrazolo[1,5-a]pyrimidin-5-yl, 1H-pyrazolo[3,4-b]pyraz ... 1H-pyrazolo[3,4-b]pyridin-5-yl, 1H-pyrazolo[3,4-b]pyridin-6-yl, 1H-pyrazolo[3,4-c]pyridin-1-yl, 1H-pyrazolo[3,4-c]pyridin-5-yl, 1H-pyrazolo[4,3-b]pyridin-5-yl, 1H-pyrazolo[4,3-b]pyridin-6-yl, 1H-pyrazolo[4,3-d]pyrimidin-5-yl, 2H-pyrazolo[4,3-b]pyridin-5-yl, 2H-pyrazolo[4,3-c]pyridin-5-yl, 5H-pyrrolo[2,3-b]pyrazin-2-yl, imidazo[1,2-a ]pyridin-2-yl, imidazo[1,2-a]pyridin-6-yl, imidazo[1,2-a]pyrazin-2-yl, imidazo[1,2-a]pyrazin-6-yl, imidazo[1,2-a]pyrimidin-2-yl, imidazo[1,2-a]pyrimidin-6-yl, imidazo[1,2-b]pyridazin-2-yl, imidazo[1,2-b]pyridazin-6-yl, imidazo[1,2-c]pyrimidin-2-yl, 1H-imidazo[4,5-b]pyridin-5-yl, 3H-imidazo[4,5-b]pyridin-5-yl, imidazo[2,1-b][1,3]thiazol-6-yl, imidazo[2,1-b][1,3,4]thiadiazol-6-yl, [1,3]oxazolo[4,5-b]pyridin-2-yl, [1,2,3]triazolo[1,5-a]pyridin-5-yl, [1,2,3]triazolo[1,5-a]pyridin-6-yl, 1H-[1,2,3]triazolo[4,5-b]pyridin-5-yl, 2H-[1,2,3]triazolo[4,5-b]pyridin-6-yl, 3H-[1,2,3]triazolo[4,5-b]pyridin-5-yl, [1,2,4]triazolo[1,5-a]pyridin-2-yl, [1,2,4]triazolo[1,5-a]pyridin-6-yl, [1,2,4 ]triazolo[1,5-a]pyridin-7-yl, [1,2,4]triazolo[1,5-a]pyrazin-2-yl, [1,2,4]triazolo[1,5-a]pyrazin-5-yl, [1,2,4]triazolo[1,5-a]pyrazin-6-yl, [1,2,4]triazolo[4,3-a]pyridin-6-yl, [1,2,4]triazolo[4,3-a]pyridin-7-yl, tetrazolo[1,5-a]pyridin-7-yl, tetrazolo[1,5-b]pyridazin-7-yl, quinolin-6-yl, isoquinolin-6-yl, and quinoxalin-2-yl, where available valences permit, one R, 1a This includes compounds of formula (II) which are substituted with a substituent.

[0388] Another aspect is R 1Thien-2-yl, thien-3-yl, 1H-pyrazol-1-yl, 1H-pyrazol-3-yl, 1H-pyrazol-4-yl, 1H-pyrazol-5-yl, 1H-imidazol-1-yl, 1H-imidazol-4-yl, 1,3-thiazol-2-yl, 1,3-thiazol-5-yl, 1,3-oxazol-2-yl, 1,3-oxazol-4-yl, 1,3-oxazol-5-yl, 1,2,4-oxadiazol-3-yl, 1,3,4-oxadiazol-2-yl, 1,2,4-thiadiazol-5-yl, 1H-1, 2,3-Triazol-1-yl, 1H-1,2,3-triazol-4-yl, 1H-1,2,3-triazol-5-yl, 2H-1,2,3-triazol-2-yl, 2H-1,2,3-triazol-4-yl, 1H-1,2,4-triazol-1-yl, 1H-1,2,4-triazol-3-yl, 1H-1,2,4-triazol-5-yl, 1H-tetrazol-1-yl, 1H-tetrazol-5-yl, 2H-tetrazol-2-yl, 2H-tetrazol-5-yl, pyridin-2-yl, pyridin-3-yl, pyridin- 4-yl, pyridin-2(1H)-one-4-yl, pyridin-2(1H)-one-5-yl, pyridin-2(1H)-one-6-yl, pyrazin-2-yl, pyrazin-3-yl, pyrimidin-2-yl, pyrimidin-4-yl, pyrimidin-5-yl, pyrimidin-4(3H)-one-6-yl, pyridazin-3-yl, pyridazin-4-yl, pyridazin-3(2H)-one-5-yl, 1,2,4-triazin-3-yl, 1,3,5-triazin-2-yl, 1H-indol-3-yl, 1H-indol-4-yl, 1H-indol- 5-yl, 1H-indol-6-yl, 1H-indazol-5-yl, 1H-indazol-6-yl, 2H-indazol-4-yl, 2H-indazol-5-yl, 2H-indazol-6-yl, indolizin-2-yl, benzofuran-2-yl, benzofuran-5-yl, benzothien-2-yl, benzothien-3-yl, 1H-benzimidazol-2-yl, 1H-benzimidazol-5-yl, 1H-benzimidazol-6-yl, 1,3-benzoxazol-2-yl, 1,3-benzoxazol-5-yl, 1,3-Benzoxazol-6-yl, 1,3-benzothiazol-2-yl, 1,3-benzothiazol-5-yl, 1,3-benzothiazol-6-yl, 1,3-benzodioxol-5-yl, 1,2,3-benzotriazol-5-yl, 9H-purin-8-yl, furo[3,2-b]pyridin-2-yl, furo[3,2-c]pyridin-2-yl, furo[2,3-c]pyridin-2-yl, 1,3-oxazolo[5,4-b]pyridin-5-yl, thieno[3,2-c]pyridin-2-yl, thieno[2,3-d]pyrimidin-6-yl pyrrolo[2,3-b]pyridin-5-yl, 1H-pyrrolo[2,3-c]pyridin-4-yl, pyrrolo[1,2-a]pyrimidin-7-yl, pyrrolo[1,2-a]pyrazin-7-yl, pyrrolo[1,2-b]pyridazin-2-yl, pyrazolo[1,5-a]pyridin-2-yl, pyrazolo[1,5-a]pyridin-5-yl, pyrazolo[1,5-a]pyrazin-2-yl, pyrazolo[1,5-a]pyrimidin-2-yl, pyrazolo[1,5-a]pyrimidin-5-yl, 1H-pyrazolo[3,4-b]pyraz ... 1H-pyrazolo[3,4-b]pyridin-5-yl, 1H-pyrazolo[3,4-b]pyridin-6-yl, 1H-pyrazolo[3,4-c]pyridin-1-yl, 1H-pyrazolo[3,4-c]pyridin-5-yl, 1H-pyrazolo[4,3-b]pyridin-5-yl, 1H-pyrazolo[4,3-b]pyridin-6-yl, 1H-pyrazolo[4,3-d]pyrimidin-5-yl, 2H-pyrazolo[4,3-b]pyridin-5-yl, 2H-pyrazolo[4,3-c]pyridin-5-yl, 5H-pyrrolo[2,3-b]pyrazin-2-yl, imidazo[1,2-a ]pyridin-2-yl, imidazo[1,2-a]pyridin-6-yl, imidazo[1,2-a]pyrazin-2-yl, imidazo[1,2-a]pyrazin-6-yl, imidazo[1,2-a]pyrimidin-2-yl, imidazo[1,2-a]pyrimidin-6-yl, imidazo[1,2-b]pyridazin-2-yl, imidazo[1,2-b]pyridazin-6-yl, imidazo[1,2-c]pyrimidin-2-yl, 1H-imidazo[4,5-b]pyridin-5-yl, 3H-imidazo[4,5-b]pyridin-5-yl, imidazo[2,1-b][1,3]thiazol-6-yl, imidazo[2,1-b][1,3,4]thiadiazol-6-yl, [1,3]oxazolo[4,5-b]pyridin-2-yl, [1,2,3]triazolo[1,5-a]pyridin-5-yl, [1,2,3]triazolo[1,5-a]pyridin-6-yl, 1H-[1,2,3]triazolo[4,5-b]pyridin-5-yl, 2H-[1,2,3]triazolo[4,5-b]pyridin-6-yl, 3H-[1,2,3]triazolo[4,5-b]pyridin-5-yl, [1,2,4]triazolo[1,5-a]pyridin-2-yl, [1,2,4]triazolo[1,5-a]pyridin-6-yl, [1,2,4 ]triazolo[1,5-a]pyridin-7-yl, [1,2,4]triazolo[1,5-a]pyrazin-2-yl, [1,2,4]triazolo[1,5-a]pyrazin-5-yl, [1,2,4]triazolo[1,5-a]pyrazin-6-yl, [1,2,4]triazolo[4,3-a]pyridin-6-yl, [1,2,4]triazolo[4,3-a]pyridin-7-yl, tetrazolo[1,5-a]pyridin-7-yl, tetrazolo[1,5-b]pyridazin-7-yl, quinolin-6-yl, isoquinolin-6-yl, and quinoxalin-2-yl, where available valences permit, two R, 1a This includes compounds of formula (II) which are substituted with a substituent.

[0389] Another aspect is R 1 is heteroaryl selected from 1H-pyrazol-4-yl, 2H-1,2,3-triazol-2-yl, 2H-indazol-5-yl, imidazo[1,2-a]pyridin-6-yl, imidazo[1,2-b]pyridazin-6-yl, and 2H-[1,2,3]triazolo[4,5-b]pyridin-6-yl, where available valences permit, one or two R 1a This includes compounds of formula (II) which may be substituted with a substituent.

[0390] Another aspect is R 1is an unsubstituted heteroaryl selected from 1H-pyrazol-4-yl, 2H-1,2,3-triazol-2-yl, 2H-indazol-5-yl, imidazo[1,2-a]pyridin-6-yl, imidazo[1,2-b]pyridazin-6-yl, and 2H-[1,2,3]triazolo[4,5-b]pyridin-6-yl.

[0391] Another aspect is R 1 is heteroaryl selected from 1H-pyrazol-4-yl, 2H-1,2,3-triazol-2-yl, 2H-indazol-5-yl, imidazo[1,2-a]pyridin-6-yl, imidazo[1,2-b]pyridazin-6-yl, and 2H-[1,2,3]triazolo[4,5-b]pyridin-6-yl, if permitted by available valences, and 1a This includes compounds of formula (II) which are substituted with a substituent.

[0392] Another aspect is R 1 is heteroaryl selected from 1H-pyrazol-4-yl, 2H-1,2,3-triazol-2-yl, 2H-indazol-5-yl, imidazo[1,2-a]pyridin-6-yl, imidazo[1,2-b]pyridazin-6-yl, and 2H-[1,2,3]triazolo[4,5-b]pyridin-6-yl, where available valences permit, two R 1a This includes compounds of formula (II) which are substituted with a substituent.

[0393] Another aspect is R 1is heteroaryl-amino, wherein heteroaryl is thienyl, 1H-pyrazolyl, 1H-imidazolyl, 1,3-thiazolyl, oxazolyl, 1,2,4-oxadiazolyl, 1,3,4-oxadiazolyl, 1,2,4-thiadiazolyl, 1H-tetrazolyl, 2H-tetrazolyl, pyridinyl, pyrazinyl, pyrimidinyl, pyridazinyl, 1,2,4-tri ... is selected from diphenyl, 1,3,5-triazinyl, 1H-indolyl, 1H-indazolyl, 2H-indazolyl, indolizinyl, benzofuranyl, benzothienyl, 1H-benzimidazolyl, 1,3-benzoxazolyl, 1,3-benzothiazolyl, 1,3-benzodioxolyl, 1,2,3-benzotriazolyl, 9H-purinyl, quinolinyl, isoquinolinyl, and quinoxalinyl; Heteroaryl may contain one or two R, where available valences permit. 1a It may be substituted with a substituent.

[0394] Another aspect is R 1 is (pyrazin-2-yl)amino and, if permitted by available valences, one or two R 1a This includes compounds of formula (II) which may be substituted with a substituent.

[0395] In one embodiment, R 1a But halogen, hydroxyl, cyano, C 1-4 Alkyl, Deuterium-C 1-4 Alkyl, halo-C 1-4 Alkyl, Amino, C 1-4 Alkyl-amino, (C 1-4 Alkyl) 2 - Amino, C 1-4 Alkoxy, Deuterium-C 1-4 Alkoxy, and halo-C 1-4 The compounds of formula (II) include those compounds of formula (II) in which each is independently selected from alkoxy.

[0396] Another aspect is R 1a But halogen, cyano, C 1-4 Alkyl, Deuterium-C 1-4 Alkyl, and C1-4 The compounds of formula (II) include those compounds of formula (II) in which each is independently selected from alkoxy.

[0397] Another aspect is R 1a is selected from methyl, ethyl, propyl, isopropyl, butyl, and tert-butyl; 1-4 This includes compounds of formula (II) in which:

[0398] Another aspect is R 1a is methyl.

[0399] Another aspect is R 1a is a halogen selected from bromo, chloro, fluoro, and iodo.

[0400] Another aspect is R 1a is fluoro.

[0401] Another aspect is R 1a is cyano.

[0402] Another aspect is R 1a But deuterium C 1-4 Alkyl, C 1-4 Alkyl includes compounds of formula (II) where available valences permit, selected from methyl, ethyl, propyl, isopropyl, butyl, and tert-butyl, partially or fully substituted with one or more deuterium atoms.

[0403] Another aspect is R 1a but( 2 H 3 ) methyl.

[0404] Another aspect is R 1a is selected from methoxy, ethoxy, propoxy, isopropoxy, butoxy and tert-butoxy; 1-4 This includes compounds of formula (II) which are alkoxy.

[0405] Another aspect is R 1a is methoxy.

[0406] Another aspect of the present invention includes a compound of formula (III), or a form thereof: [ka] (In the formula, X is O, NR x , or a bond, R x is hydrogen and C 1-4 alkyl, B is heterocyclyl; Heterocyclyl is a saturated or partially unsaturated 3- to 7-membered monocyclic, 6- to 10-membered bicyclic, or 13- to 16-membered polycyclic ring system having 1, 2, or 3 heteroatom ring members independently selected from N, O, or S, and, where permitted by available valences, 1, 2, 3, 4, or 5 R b each of which may be substituted with a substituent; R b is a halogen, C 1-4 Alkyl, Amino, C 1-4 Alkyl-amino, (C 1-4 Alkyl) 2 -Amino and C 3-6 cycloalkyl; R 1 Heteroaryl, heterocyclyl, phenyl, heteroaryl-C 1-4 Alkyl, Heteroaryl-C 2-4 Alkenyl, Heteroaryl-amino, Heteroaryl-C 1-4 alkyl-amino; Heteroaryl is a 3-7 membered monocyclic or 6-10 membered bicyclic ring system having 1, 2, 3, or 4 heteroatom ring members independently selected from N, O, or S; Heterocyclyl is a saturated or partially unsaturated 3- to 7-membered monocyclic, 6- to 10-membered bicyclic or 13- to 16-membered polycyclic ring system having 1, 2 or 3 heteroatom ring members independently selected from N, O or S; Each example of phenyl, heteroaryl, or heterocyclyl may have one or two R 1a may be substituted with a substituent; R 1a is halogen, hydroxyl, cyano, C 1-4 Alkyl, Deuterium-C 1-4 Alkyl, halo-C 1-4 Alkyl, Amino, C 1-4 Alkyl-amino, (C 1-4 Alkyl) 2 - Amino, C 1-4 Alkoxy, Deuterium-C 1-4 Alkoxy, and halo-C 1-4 alkoxy)

[0407] In one embodiment, X is O, NR x and a bond.

[0408] Another embodiment is where X is NR x

[0033] The present invention includes compounds of formula (III)

[0409] Another embodiment includes compounds of formula (III) where X is a bond.

[0410] In one embodiment, R x But hydrogen and C 1-4 The compound of formula (III) includes compounds of formula (III) wherein the alkyl is selected from the group consisting of aryl, ... and alkyl.

[0411] Another aspect is R x is hydrogen.

[0412] Another aspect is R x is selected from methyl, ethyl, propyl, isopropyl, butyl, and tert-butyl; 1-4This includes compounds of formula (III) wherein:

[0413] Another aspect is R x is methyl.

[0414] In one embodiment, B is heterocyclyl, which is a saturated or partially unsaturated 3-7 membered monocyclic, 6-10 membered bicyclic, or 13-16 membered polycyclic ring system having 1, 2, or 3 heteroatom ring members independently selected from N, O, or S, and, where permitted by available valences, 1, 2, 3, 4, or 5 R b The compounds of formula (III) include those which may be substituted with a substituent.

[0415] Another embodiment is where B is heterocyclyl, which is a saturated or partially unsaturated 3-7 membered monocyclic, 6-10 membered bicyclic, or 13-16 membered polycyclic ring system having 1, 2, or 3 heteroatom ring members independently selected from N, O, or S, and where available valences permit, two R b This includes compounds of formula (III) which are substituted with a substituent.

[0416] Another embodiment is where B is heterocyclyl, which is a saturated or partially unsaturated 3-7 membered monocyclic, 6-10 membered bicyclic, or 13-16 membered polycyclic ring system having 1, 2, or 3 heteroatom ring members independently selected from N, O, or S, and, where permitted by available valences, four R b This includes compounds of formula (III) which are substituted with a substituent.

[0417] Another embodiment is where B is azetidinyl, tetrahydrofuranyl, pyrrolidinyl, piperidinyl, piperidin-1-olate-yl, piperazinyl, 1,4-diazepanyl, 1,2-dihydropyridinyl, 1,2,5,6-tetrahydropyridinyl, 1,2,3,6-tetrahydropyridinyl, hexahydrocyclopentapyrrol-(1H)-yl, hexahydropyrrolo[3,2-b]pyrrol-(2H)-yl, hexahydropyrrolo[3,4-b]pyrrol-(2H)-yl, octahydro-2H-pyrrolo[3,4-c]pyridinyl, octahydro-5H- Pyrrolo[3,2-c]pyridinyl, octahydro-6H-pyrrolo[3,4-b]pyridinyl, hexahydropyrrolo[1,2-a]pyrazin-(2H)-one, hexahydropyrrolo[1,2-a]pyrazin-(1H)-yl, hexahydro-1H-cyclobuta[1.2-c:1,4-c′]dipyrrol-(3H)-yl, octahydropyrrolo[1,2-a]pyrazin-(1H)-yl, octahydro-2H-pyrido[1,2-a]pyrazinyl, hexahydropyrrolo[3,4-b][1,4]oxazin-(2H)-yl, 5-azaspiro[2.4]hepta nyl, 1-azaspiro[3.3]heptanyl, 4-azaspiro[2.5]octanyl, 2-oxa-6-azaspiro[3.4]octanyl, 3-azabicyclo[3.1.0]hexanyl, 8-azabicyclo[3.2.1]octanyl, 8-azabicyclo[3.2.1]oct-2-en-yl, 9-azabicyclo[3.3.1]nonanyl, 2,5-diazabicyclo[2.2.1]heptanyl, 1,4-diazabicyclo[3.1.1]heptanyl, 3,6-diazabicyclo[3.2.0]heptanyl, 2,5-diazabicyclo[2.2.2]octanyl, 1,4-diazabicyclo[3.2.1]octanyl, 3,8-diazabicyclo[3.2.1]octanyl, 1,4-diazabicyclo[3.2.2]nonanyl, 4,7-diazaspiro[2.5]octanyl, 2,6-diazaspiro[3.3]heptanyl, 1,6-diazaspiro[3.4]octanyl, 2,6-diazaspiro[3.4]octanyl, 1,7-diazaspiro[4.4]nonanyl, 1,7-diazaspiro[3.5]nonanyl, 2,6-diazaspiro[3.5]nonanyl, 2,7-diazaspiro[3.5]nonanyl, 5,8-diazaspiro[3.5]nonanyl, 2-oxa-5,8-diazaspiro[3.5]nonanyl, 2,7-diazaspiro[4.4]nonanyl, 2,7-diazaspiro[4.5]decanyl, 2,8-diazaspiro[4.5]decanyl, 6,9-diazaspiro[4.5]decyl, 6-oxa-2,9-diazaspiro[4.5]decanyl, 2,9-diazaspiro[5.5]undecanyl, 4-azadispiro[2.1.2. 5 .3 3 ]decanyl, and 7-azadispiro[5.1.5 8 .3 6 ]hexadecanyl, where available valences permit, one, two, three, four or five R b The compounds of formula (III) include those which may be substituted with a substituent.

[0418] Another embodiment is where B is azetidinyl, tetrahydrofuranyl, pyrrolidinyl, piperidinyl, piperidin-1-olate-yl, piperazinyl, 1,4-diazepanyl, 1,2-dihydropyridinyl, 1,2,5,6-tetrahydropyridinyl, 1,2,3,6-tetrahydropyridinyl, hexahydrocyclopentapyrrol-(1H)-yl, hexahydropyrrolo[3,2-b]pyrrol-(2H)-yl, hexahydropyrrolo[3,4-b]pyrrol-(2H)-yl, octahydro-2H-pyrrolo[3,4-c]pyridinyl, octahydro-5H- Pyrrolo[3,2-c]pyridinyl, octahydro-6H-pyrrolo[3,4-b]pyridinyl, hexahydropyrrolo[1,2-a]pyrazin-(2H)-one, hexahydropyrrolo[1,2-a]pyrazin-(1H)-yl, hexahydro-1H-cyclobuta[1.2-c:1,4-c′]dipyrrol-(3H)-yl, octahydropyrrolo[1,2-a]pyrazin-(1H)-yl, octahydro-2H-pyrido[1,2-a]pyrazinyl, hexahydropyrrolo[3,4-b][1,4]oxazin-(2H)-yl, 5-azaspiro[2.4]hepta nyl, 1-azaspiro[3.3]heptanyl, 4-azaspiro[2.5]octanyl, 2-oxa-6-azaspiro[3.4]octanyl, 3-azabicyclo[3.1.0]hexanyl, 8-azabicyclo[3.2.1]octanyl, 8-azabicyclo[3.2.1]oct-2-en-yl, 9-azabicyclo[3.3.1]nonanyl, 2,5-diazabicyclo[2.2.1]heptanyl, 1,4-diazabicyclo[3.1.1]heptanyl, 3,6-diazabicyclo[3.2.0]heptanyl, 2,5-diazabicyclo[2.2.2]octanyl, 1,4-diazabicyclo[3.2.1]octanyl, 3,8-diazabicyclo[3.2.1]octanyl, 1,4-diazabicyclo[3.2.2]nonanyl, 4,7-diazaspiro[2.5]octanyl, 2,6-diazaspiro[3.3]heptanyl, 1,6-diazaspiro[3.4]octanyl, 2,6-diazaspiro[3.4]octanyl, 1,7-diazaspiro[4.4]nonanyl, 1,7-diazaspiro[3.5]nonanyl, 2,6-diazaspiro[3.5]nonanyl, 2,7-diazaspiro[3.5]nonanyl, 5,8-diazaspiro[3.5]nonanyl, 2-oxa-5,8-diazaspiro[3.5]nonanyl, 2,7-diazaspiro[4.4]nonanyl, 2,7-diazaspiro[4.5]decanyl, 2,8-diazaspiro[4.5]decanyl, 6,9-diazaspiro[4.5]decyl, 6-oxa-2,9-diazaspiro[4.5]decanyl, 2,9-diazaspiro[5.5]undecanyl, 4-azadispiro[2.1.2. 5 .3 3 ]decanyl, and 7-azadispiro[5.1.5 8 .3 6 ]hexadecanyl.

[0419] Another embodiment is where B is azetidinyl, tetrahydrofuranyl, pyrrolidinyl, piperidinyl, piperidin-1-olate-yl, piperazinyl, 1,4-diazepanyl, 1,2-dihydropyridinyl, 1,2,5,6-tetrahydropyridinyl, 1,2,3,6-tetrahydropyridinyl, hexahydrocyclopentapyrrol-(1H)-yl, hexahydropyrrolo[3,2-b]pyrrol-(2H)-yl, hexahydropyrrolo[3,4-b]pyrrol-(2H)-yl, octahydro-2H-pyrrolo[3,4-c]pyridinyl, octahydro-5H- Pyrrolo[3,2-c]pyridinyl, octahydro-6H-pyrrolo[3,4-b]pyridinyl, hexahydropyrrolo[1,2-a]pyrazin-(2H)-one, hexahydropyrrolo[1,2-a]pyrazin-(1H)-yl, hexahydro-1H-cyclobuta[1.2-c:1,4-c′]dipyrrol-(3H)-yl, octahydropyrrolo[1,2-a]pyrazin-(1H)-yl, octahydro-2H-pyrido[1,2-a]pyrazinyl, hexahydropyrrolo[3,4-b][1,4]oxazin-(2H)-yl, 5-azaspiro[2.4]hepta nyl, 1-azaspiro[3.3]heptanyl, 4-azaspiro[2.5]octanyl, 2-oxa-6-azaspiro[3.4]octanyl, 3-azabicyclo[3.1.0]hexanyl, 8-azabicyclo[3.2.1]octanyl, 8-azabicyclo[3.2.1]oct-2-en-yl, 9-azabicyclo[3.3.1]nonanyl, 2,5-diazabicyclo[2.2.1]heptanyl, 1,4-diazabicyclo[3.1.1]heptanyl, 3,6-diazabicyclo[3.2.0]heptanyl, 2,5-diazabicyclo[2.2.2]octanyl, 1,4-diazabicyclo[3.2.1]octanyl, 3,8-diazabicyclo[3.2.1]octanyl, 1,4-diazabicyclo[3.2.2]nonanyl, 4,7-diazaspiro[2.5]octanyl, 2,6-diazaspiro[3.3]heptanyl, 1,6-diazaspiro[3.4]octanyl, 2,6-diazaspiro[3.4]octanyl, 1,7-diazaspiro[4.4]nonanyl, 1,7-diazaspiro[3.5]nonanyl, 2,6-diazaspiro[3.5]nonanyl, 2,7-diazaspiro[3.5]nonanyl, 5,8-diazaspiro[3.5]nonanyl, 2-oxa-5,8-diazaspiro[3.5]nonanyl, 2,7-diazaspiro[4.4]nonanyl, 2,7-diazaspiro[4.5]decanyl, 2,8-diazaspiro[4.5]decanyl, 6,9-diazaspiro[4.5]decyl, 6-oxa-2,9-diazaspiro[4.5]decanyl, 2,9-diazaspiro[5.5]undecanyl, 4-azadispiro[2.1.2. 5 .3 3 ]decanyl, and 7-azadispiro[5.1.5 8 .3 6 ]hexadecanyl, where available valences permit, one R b The compounds of formula (III) include those which may be substituted with a substituent.

[0420] Another embodiment is where B is azetidinyl, tetrahydrofuranyl, pyrrolidinyl, piperidinyl, piperidin-1-olate-yl, piperazinyl, 1,4-diazepanyl, 1,2-dihydropyridinyl, 1,2,5,6-tetrahydropyridinyl, 1,2,3,6-tetrahydropyridinyl, hexahydrocyclopentapyrrol-(1H)-yl, hexahydropyrrolo[3,2-b]pyrrol-(2H)-yl, hexahydropyrrolo[3,4-b]pyrrol-(2H)-yl, octahydro-2H-pyrrolo[3,4-c]pyridinyl, octahydro-5H- Pyrrolo[3,2-c]pyridinyl, octahydro-6H-pyrrolo[3,4-b]pyridinyl, hexahydropyrrolo[1,2-a]pyrazin-(2H)-one, hexahydropyrrolo[1,2-a]pyrazin-(1H)-yl, hexahydro-1H-cyclobuta[1.2-c:1,4-c′]dipyrrol-(3H)-yl, octahydropyrrolo[1,2-a]pyrazin-(1H)-yl, octahydro-2H-pyrido[1,2-a]pyrazinyl, hexahydropyrrolo[3,4-b][1,4]oxazin-(2H)-yl, 5-azaspiro[2.4]hepta nyl, 1-azaspiro[3.3]heptanyl, 4-azaspiro[2.5]octanyl, 2-oxa-6-azaspiro[3.4]octanyl, 3-azabicyclo[3.1.0]hexanyl, 8-azabicyclo[3.2.1]octanyl, 8-azabicyclo[3.2.1]oct-2-en-yl, 9-azabicyclo[3.3.1]nonanyl, 2,5-diazabicyclo[2.2.1]heptanyl, 1,4-diazabicyclo[3.1.1]heptanyl, 3,6-diazabicyclo[3.2.0]heptanyl, 2,5-diazabicyclo[2.2.2]octanyl, 1,4-diazabicyclo[3.2.1]octanyl, 3,8-diazabicyclo[3.2.1]octanyl, 1,4-diazabicyclo[3.2.2]nonanyl, 4,7-diazaspiro[2.5]octanyl, 2,6-diazaspiro[3.3]heptanyl, 1,6-diazaspiro[3.4]octanyl, 2,6-diazaspiro[3.4]octanyl, 1,7-diazaspiro[4.4]nonanyl, 1,7-diazaspiro[3.5]nonanyl, 2,6-diazaspiro[3.5]nonanyl, 2,7-diazaspiro[3.5]nonanyl, 5,8-diazaspiro[3.5]nonanyl, 2-oxa-5,8-diazaspiro[3.5]nonanyl, 2,7-diazaspiro[4.4]nonanyl, 2,7-diazaspiro[4.5]decanyl, 2,8-diazaspiro[4.5]decanyl, 6,9-diazaspiro[4.5]decyl, 6-oxa-2,9-diazaspiro[4.5]decanyl, 2,9-diazaspiro[5.5]undecanyl, 4-azadispiro[2.1.2. 5 .3 3 ]decanyl, and 7-azadispiro[5.1.5 8 .3 6 ]hexadecanyl, where available valences permit, two R b The compounds of formula (III) include those which may be substituted with a substituent.

[0421] Another embodiment is where B is azetidinyl, tetrahydrofuranyl, pyrrolidinyl, piperidinyl, piperidin-1-olate-yl, piperazinyl, 1,4-diazepanyl, 1,2-dihydropyridinyl, 1,2,5,6-tetrahydropyridinyl, 1,2,3,6-tetrahydropyridinyl, hexahydrocyclopentapyrrol-(1H)-yl, hexahydropyrrolo[3,2-b]pyrrol-(2H)-yl, hexahydropyrrolo[3,4-b]pyrrol-(2H)-yl, octahydro-2H-pyrrolo[3,4-c]pyridinyl, octahydro-5H- Pyrrolo[3,2-c]pyridinyl, octahydro-6H-pyrrolo[3,4-b]pyridinyl, hexahydropyrrolo[1,2-a]pyrazin-(2H)-one, hexahydropyrrolo[1,2-a]pyrazin-(1H)-yl, hexahydro-1H-cyclobuta[1.2-c:1,4-c′]dipyrrol-(3H)-yl, octahydropyrrolo[1,2-a]pyrazin-(1H)-yl, octahydro-2H-pyrido[1,2-a]pyrazinyl, hexahydropyrrolo[3,4-b][1,4]oxazin-(2H)-yl, 5-azaspiro[2.4]hepta nyl, 1-azaspiro[3.3]heptanyl, 4-azaspiro[2.5]octanyl, 2-oxa-6-azaspiro[3.4]octanyl, 3-azabicyclo[3.1.0]hexanyl, 8-azabicyclo[3.2.1]octanyl, 8-azabicyclo[3.2.1]oct-2-en-yl, 9-azabicyclo[3.3.1]nonanyl, 2,5-diazabicyclo[2.2.1]heptanyl, 1,4-diazabicyclo[3.1.1]heptanyl, 3,6-diazabicyclo[3.2.0]heptanyl, 2,5-diazabicyclo[2.2.2]octanyl, 1,4-diazabicyclo[3.2.1]octanyl, 3,8-diazabicyclo[3.2.1]octanyl, 1,4-diazabicyclo[3.2.2]nonanyl, 4,7-diazaspiro[2.5]octanyl, 2,6-diazaspiro[3.3]heptanyl, 1,6-diazaspiro[3.4]octanyl, 2,6-diazaspiro[3.4]octanyl, 1,7-diazaspiro[4.4]nonanyl, 1,7-diazaspiro[3.5]nonanyl, 2,6-diazaspiro[3.5]nonanyl, 2,7-diazaspiro[3.5]nonanyl, 5,8-diazaspiro[3.5]nonanyl, 2-oxa-5,8-diazaspiro[3.5]nonanyl, 2,7-diazaspiro[4.4]nonanyl, 2,7-diazaspiro[4.5]decanyl, 2,8-diazaspiro[4.5]decanyl, 6,9-diazaspiro[4.5]decyl, 6-oxa-2,9-diazaspiro[4.5]decanyl, 2,9-diazaspiro[5.5]undecanyl, 4-azadispiro[2.1.2. 5 .3 3 ]decanyl, and 7-azadispiro[5.1.5 8 .3 6 ]hexadecanyl, where available valences permit, and three R b The compounds of formula (III) include those which may be substituted with a substituent.

[0422] Another embodiment is where B is azetidinyl, tetrahydrofuranyl, pyrrolidinyl, piperidinyl, piperidin-1-olate-yl, piperazinyl, 1,4-diazepanyl, 1,2-dihydropyridinyl, 1,2,5,6-tetrahydropyridinyl, 1,2,3,6-tetrahydropyridinyl, hexahydrocyclopentapyrrol-(1H)-yl, hexahydropyrrolo[3,2-b]pyrrol-(2H)-yl, hexahydropyrrolo[3,4-b]pyrrol-(2H)-yl, octahydro-2H-pyrrolo[3,4-c]pyridinyl, octahydro-5H- Pyrrolo[3,2-c]pyridinyl, octahydro-6H-pyrrolo[3,4-b]pyridinyl, hexahydropyrrolo[1,2-a]pyrazin-(2H)-one, hexahydropyrrolo[1,2-a]pyrazin-(1H)-yl, hexahydro-1H-cyclobuta[1.2-c:1,4-c′]dipyrrol-(3H)-yl, octahydropyrrolo[1,2-a]pyrazin-(1H)-yl, octahydro-2H-pyrido[1,2-a]pyrazinyl, hexahydropyrrolo[3,4-b][1,4]oxazin-(2H)-yl, 5-azaspiro[2.4]hepta nyl, 1-azaspiro[3.3]heptanyl, 4-azaspiro[2.5]octanyl, 2-oxa-6-azaspiro[3.4]octanyl, 3-azabicyclo[3.1.0]hexanyl, 8-azabicyclo[3.2.1]octanyl, 8-azabicyclo[3.2.1]oct-2-en-yl, 9-azabicyclo[3.3.1]nonanyl, 2,5-diazabicyclo[2.2.1]heptanyl, 1,4-diazabicyclo[3.1.1]heptanyl, 3,6-diazabicyclo[3.2.0]heptanyl, 2,5-diazabicyclo[2.2.2]octanyl, 1,4-diazabicyclo[3.2.1]octanyl, 3,8-diazabicyclo[3.2.1]octanyl, 1,4-diazabicyclo[3.2.2]nonanyl, 4,7-diazaspiro[2.5]octanyl, 2,6-diazaspiro[3.3]heptanyl, 1,6-diazaspiro[3.4]octanyl, 2,6-diazaspiro[3.4]octanyl, 1,7-diazaspiro[4.4]nonanyl, 1,7-diazaspiro[3.5]nonanyl, 2,6-diazaspiro[3.5]nonanyl, 2,7-diazaspiro[3.5]nonanyl, 5,8-diazaspiro[3.5]nonanyl, 2-oxa-5,8-diazaspiro[3.5]nonanyl, 2,7-diazaspiro[4.4]nonanyl, 2,7-diazaspiro[4.5]decanyl, 2,8-diazaspiro[4.5]decanyl, 6,9-diazaspiro[4.5]decyl, 6-oxa-2,9-diazaspiro[4.5]decanyl, 2,9-diazaspiro[5.5]undecanyl, 4-azadispiro[2.1.2. 5 .3 3 ]decanyl, and 7-azadispiro[5.1.5 8 .3 6 ]hexadecanyl, where available valences permit, four R b The compounds of formula (III) include those which may be substituted with a substituent.

[0423] Another embodiment is where B is azetidinyl, tetrahydrofuranyl, pyrrolidinyl, piperidinyl, piperidin-1-olate-yl, piperazinyl, 1,4-diazepanyl, 1,2-dihydropyridinyl, 1,2,5,6-tetrahydropyridinyl, 1,2,3,6-tetrahydropyridinyl, hexahydrocyclopentapyrrol-(1H)-yl, hexahydropyrrolo[3,2-b]pyrrol-(2H)-yl, hexahydropyrrolo[3,4-b]pyrrol-(2H)-yl, octahydro-2H-pyrrolo[3,4-c]pyridinyl, octahydro-5H- Pyrrolo[3,2-c]pyridinyl, octahydro-6H-pyrrolo[3,4-b]pyridinyl, hexahydropyrrolo[1,2-a]pyrazin-(2H)-one, hexahydropyrrolo[1,2-a]pyrazin-(1H)-yl, hexahydro-1H-cyclobuta[1.2-c:1,4-c′]dipyrrol-(3H)-yl, octahydropyrrolo[1,2-a]pyrazin-(1H)-yl, octahydro-2H-pyrido[1,2-a]pyrazinyl, hexahydropyrrolo[3,4-b][1,4]oxazin-(2H)-yl, 5-azaspiro[2.4]hepta nyl, 1-azaspiro[3.3]heptanyl, 4-azaspiro[2.5]octanyl, 2-oxa-6-azaspiro[3.4]octanyl, 3-azabicyclo[3.1.0]hexanyl, 8-azabicyclo[3.2.1]octanyl, 8-azabicyclo[3.2.1]oct-2-en-yl, 9-azabicyclo[3.3.1]nonanyl, 2,5-diazabicyclo[2.2.1]heptanyl, 1,4-diazabicyclo[3.1.1]heptanyl, 3,6-diazabicyclo[3.2.0]heptanyl, 2,5-diazabicyclo[2.2.2]octanyl, 1,4-diazabicyclo[3.2.1]octanyl, 3,8-diazabicyclo[3.2.1]octanyl, 1,4-diazabicyclo[3.2.2]nonanyl, 4,7-diazaspiro[2.5]octanyl, 2,6-diazaspiro[3.3]heptanyl, 1,6-diazaspiro[3.4]octanyl, 2,6-diazaspiro[3.4]octanyl, 1,7-diazaspiro[4.4]nonanyl, 1,7-diazaspiro[3.5]nonanyl, 2,6-diazaspiro[3.5]nonanyl, 2,7-diazaspiro[3.5]nonanyl, 5,8-diazaspiro[3.5]nonanyl, 2-oxa-5,8-diazaspiro[3.5]nonanyl, 2,7-diazaspiro[4.4]nonanyl, 2,7-diazaspiro[4.5]decanyl, 2,8-diazaspiro[4.5]decanyl, 6,9-diazaspiro[4.5]decyl, 6-oxa-2,9-diazaspiro[4.5]decanyl, 2,9-diazaspiro[5.5]undecanyl, 4-azadispiro[2.1.2. 5 .3 3 ]decanyl, and 7-azadispiro[5.1.5 8 .3 6 ]hexadecanyl, where available valences permit, five R b The compounds of formula (III) include those which may be substituted with a substituent.

[0424] Another embodiment is where B is heterocyclyl selected from piperidinyl and piperazinyl and, where available valences permit, 1, 2, 3, 4 or 5 R b The compounds of formula (III) include those which may be substituted with a substituent.

[0425] Another embodiment includes compounds of formula (III) where B is unsubstituted heterocyclyl selected from piperidinyl and piperazinyl.

[0426] Another embodiment is where B is heterocyclyl selected from piperidinyl and piperazinyl, and where available valences permit, one R b This includes compounds of formula (III) which are substituted with a substituent.

[0427] Another embodiment is where B is heterocyclyl selected from piperidinyl and piperazinyl, and where available valences permit, two R b This includes compounds of formula (III) which are substituted with a substituent.

[0428] Another embodiment is where B is heterocyclyl selected from piperidinyl and piperazinyl, and where available valences permit, three R bThis includes compounds of formula (III) which are substituted with a substituent.

[0429] Another embodiment is where B is heterocyclyl selected from piperidinyl and piperazinyl, and where available valences permit, four R b This includes compounds of formula (III) which are substituted with a substituent.

[0430] Another embodiment is where B is heterocyclyl selected from piperidinyl and piperazinyl, and where available valences permit, five R b This includes compounds of formula (III) which are substituted with a substituent.

[0431] Another embodiment is where B is piperidinyl and, where available valences allow, four R b This includes compounds of formula (III) which are substituted with a substituent.

[0432] Another embodiment is where B is piperazinyl and where available valences allow, two R b This includes compounds of formula (III) which are substituted with a substituent.

[0433] Another embodiment is where B is azetidin-1-yl, tetrahydrofuran-3-yl, pyrrolidin-1-yl, pyrrolidin-3-yl, piperidin-1-yl, piperidin-3-yl, piperidin-4-yl, piperidin-1-olate-4-yl, piperazin-1-yl, 1,4-diazepin-1-yl, 1,2-dihydropyridin-2-yl, 1,2-dihydropyridin-3-yl, 1,2-dihydropyridin-4-yl, 1,2-dihydropyridin-5-yl, 1,2-dihydropyridin-6-yl, 1,2,5,6-tetrahydropyridine-5-yl, 1,2,5,6-tetrahydropyridine ... -yl, 1,2,3,6-tetrahydropyridin-4-yl, hexahydrocyclopentapyrrol-2(1H)-yl, hexahydropyrrolo[3,2-b]pyrrol-1(2H)-yl, hexahydropyrrolo[3,4-b]pyrrol-1(2H)-yl, hexahydropyrrolo[3,4-c]pyrrol-1(1H)-yl, hexahydropyrrolo[3,4-c]pyrrol-2(1H)-yl, hexahydropyrrolo[3,4-c]pyrrol-5(1H)-yl, octahydro-5H-pyrrolo[3,2-c]pyridin-5-yl, octahydro-6H- Pyrrolo[3,4-b]pyridin-6-yl, hexahydropyrrolo[1,2-a]pyrazin-6(2H)-one, hexahydropyrrolo[1,2-a]pyrazin-2(1H)-yl, hexahydro-1H-cyclobuta[1.2-c:1,4-c′]dipyrrol-2(3H)-yl, octahydropyrrolo[1,2-a]pyrazin-2(1H)-yl, octahydro-2H-pyrido[1,2-a]pyrazin-2-yl, hexahydropyrrolo[3,4-b][1,4]oxazin-6(2H)-yl, 5-azaspiro[2.4]heptan-5-yl, 1- Azaspiro[3.3]heptan-2-yl, 4-azaspiro[2.5]octan-7-yl, 2-oxa-6-azaspiro[3.4]octan-6-yl, 3-azabicyclo[3.1.0]hexan-3-yl, 8-azabicyclo[3.2.1]octan-3-yl, 8-azabicyclo[3.2.1]oct-2-en-3-yl, 9-azabicyclo[3.3.1]nonan-3-yl, 2,5-diazabicyclo[2.2.1]heptan-2-yl, 1,4-diazabicyclo[3.1.1]heptan-4-yl, 3,6-diazabicyclo[3.2.0]heptan-3-yl, 3,6-diazabicyclo[3.2.0]heptan-6-yl, 2,5-diazabicyclo[2.2.2]octan-2-yl, 1,4-diazabicyclo[3.2.1]octan-4-yl, 3,8-diazabicyclo[3.2.1]octan-3-yl, 1,4-diazabicyclo[3.2.2]nonan-4-yl, 4,7-diazaspiro[2.5]octan-4-yl, 4,7-diazaspiro[2.5]octan-4-yl, 2,6-diazaspiro[3.3]heptan-2-yl, 1,6-diazaspiro[3.4]octan-6-yl, 2,6-diazaspiro[3.4]octan-2-yl, 2,6-diazaspiro[3.4]octan-6-yl, 1,7-diazaspiro[4.4]nonan-1-yl, 1,7-diazaspiro[4.4]nonan-7-yl, 1,7-diazaspiro[3.5]nonane- 7-yl, 2,6-diazaspiro[3.5]nonan-2-yl, 2,6-diazaspiro[3.5]nonan-6-yl, 1,7-diazaspiro[3.5]nonan-7-yl, 2,7-diazaspiro[3.5]nonan-2-yl, 2,7-diazaspiro[3.5]nonan-7-yl, 5,8-diazaspiro[3.5]nonan-8-yl, 2-oxa-5,8-diazaspiro[3.5]nonan-8-yl, 2,7-diaza Zaspiro[4.4]nonan-2-yl, 2,7-diazaspiro[4.5]decan-2-yl, 2,7-diazaspiro[4.5]decan-7-yl, 2,8-diazaspiro[4.5]decan-8-yl, 6,9-diazaspiro[4.5]decan-9-yl, 6-oxa-2,9-diazaspiro[4.5]decan-2-yl, 2,9-diazaspiro[5.5]undecan-9-yl, 4-azadispiro[2.1.2]undecan-2. 5 .3 3 ]decan-9-yl, and 7-azadispiro[5.1.5 8 .3 6 ]hexadecan-15-yl, where available valences permit, 1, 2, 3, 4 or 5 R b The compounds of formula (III) include those which may be substituted with a substituent.

[0434] Another embodiment is where B is azetidin-1-yl, tetrahydrofuran-3-yl, pyrrolidin-1-yl, pyrrolidin-3-yl, piperidin-1-yl, piperidin-3-yl, piperidin-4-yl, piperidin-1-olate-4-yl, piperazin-1-yl, 1,4-diazepin-1-yl, 1,2-dihydropyridin-2-yl, 1,2-dihydropyridin-3-yl, 1,2-dihydropyridin-4-yl, 1,2-dihydropyridin-5-yl, 1,2-dihydropyridin-6-yl, 1,2,5,6-tetrahydropyridine-5-yl, 1,2,5,6-tetrahydropyridine ... -yl, 1,2,3,6-tetrahydropyridin-4-yl, hexahydrocyclopentapyrrol-2(1H)-yl, hexahydropyrrolo[3,2-b]pyrrol-1(2H)-yl, hexahydropyrrolo[3,4-b]pyrrol-1(2H)-yl, hexahydropyrrolo[3,4-c]pyrrol-1(1H)-yl, hexahydropyrrolo[3,4-c]pyrrol-2(1H)-yl, hexahydropyrrolo[3,4-c]pyrrol-5(1H)-yl, octahydro-5H-pyrrolo[3,2-c]pyridin-5-yl, octahydro-6H- Pyrrolo[3,4-b]pyridin-6-yl, hexahydropyrrolo[1,2-a]pyrazin-6(2H)-one, hexahydropyrrolo[1,2-a]pyrazin-2(1H)-yl, hexahydro-1H-cyclobuta[1.2-c:1,4-c′]dipyrrol-2(3H)-yl, octahydropyrrolo[1,2-a]pyrazin-2(1H)-yl, octahydro-2H-pyrido[1,2-a]pyrazin-2-yl, hexahydropyrrolo[3,4-b][1,4]oxazin-6(2H)-yl, 5-azaspiro[2.4]heptan-5-yl, 1- Azaspiro[3.3]heptan-2-yl, 4-azaspiro[2.5]octan-7-yl, 2-oxa-6-azaspiro[3.4]octan-6-yl, 3-azabicyclo[3.1.0]hexan-3-yl, 8-azabicyclo[3.2.1]octan-3-yl, 8-azabicyclo[3.2.1]oct-2-en-3-yl, 9-azabicyclo[3.3.1]nonan-3-yl, 2,5-diazabicyclo[2.2.1]heptan-2-yl, 1,4-diazabicyclo[3.1.1]heptan-4-yl, 3,6-diazabicyclo[3.2.0]heptan-3-yl, 3,6-diazabicyclo[3.2.0]heptan-6-yl, 2,5-diazabicyclo[2.2.2]octan-2-yl, 1,4-diazabicyclo[3.2.1]octan-4-yl, 3,8-diazabicyclo[3.2.1]octan-3-yl, 1,4-diazabicyclo[3.2.2]nonan-4-yl, 4,7-diazaspiro[2.5]octan-4-yl, 4,7-diazaspiro[2.5]octan-4-yl, 2,6-diazaspiro[3.3]heptan-2-yl, 1,6-diazaspiro[3.4]octan-6-yl, 2,6-diazaspiro[3.4]octan-2-yl, 2,6-diazaspiro[3.4]octan-6-yl, 1,7-diazaspiro[4.4]nonan-1-yl, 1,7-diazaspiro[4.4]nonan-7-yl, 1,7-diazaspiro[3.5]nonane- 7-yl, 2,6-diazaspiro[3.5]nonan-2-yl, 2,6-diazaspiro[3.5]nonan-6-yl, 1,7-diazaspiro[3.5]nonan-7-yl, 2,7-diazaspiro[3.5]nonan-2-yl, 2,7-diazaspiro[3.5]nonan-7-yl, 5,8-diazaspiro[3.5]nonan-8-yl, 2-oxa-5,8-diazaspiro[3.5]nonan-8-yl, 2,7-diaza Zaspiro[4.4]nonan-2-yl, 2,7-diazaspiro[4.5]decan-2-yl, 2,7-diazaspiro[4.5]decan-7-yl, 2,8-diazaspiro[4.5]decan-8-yl, 6,9-diazaspiro[4.5]decan-9-yl, 6-oxa-2,9-diazaspiro[4.5]decan-2-yl, 2,9-diazaspiro[5.5]undecan-9-yl, 4-azadispiro[2.1.2]undecan-2. 5 .3 3 ]decan-9-yl, and 7-azadispiro[5.1.5 8 .3 6 ]hexadecan-15-yl.

[0435] Another embodiment is where B is azetidin-1-yl, tetrahydrofuran-3-yl, pyrrolidin-1-yl, pyrrolidin-3-yl, piperidin-1-yl, piperidin-3-yl, piperidin-4-yl, piperidin-1-olate-4-yl, piperazin-1-yl, 1,4-diazepin-1-yl, 1,2-dihydropyridin-2-yl, 1,2-dihydropyridin-3-yl, 1,2-dihydropyridin-4-yl, 1,2-dihydropyridin-5-yl, 1,2-dihydropyridin-6-yl, 1,2,5,6-tetrahydropyridine-5-yl, 1,2,5,6-tetrahydropyridine ... -yl, 1,2,3,6-tetrahydropyridin-4-yl, hexahydrocyclopentapyrrol-2(1H)-yl, hexahydropyrrolo[3,2-b]pyrrol-1(2H)-yl, hexahydropyrrolo[3,4-b]pyrrol-1(2H)-yl, hexahydropyrrolo[3,4-c]pyrrol-1(1H)-yl, hexahydropyrrolo[3,4-c]pyrrol-2(1H)-yl, hexahydropyrrolo[3,4-c]pyrrol-5(1H)-yl, octahydro-5H-pyrrolo[3,2-c]pyridin-5-yl, octahydro-6H- Pyrrolo[3,4-b]pyridin-6-yl, hexahydropyrrolo[1,2-a]pyrazin-6(2H)-one, hexahydropyrrolo[1,2-a]pyrazin-2(1H)-yl, hexahydro-1H-cyclobuta[1.2-c:1,4-c′]dipyrrol-2(3H)-yl, octahydropyrrolo[1,2-a]pyrazin-2(1H)-yl, octahydro-2H-pyrido[1,2-a]pyrazin-2-yl, hexahydropyrrolo[3,4-b][1,4]oxazin-6(2H)-yl, 5-azaspiro[2.4]heptan-5-yl, 1- Azaspiro[3.3]heptan-2-yl, 4-azaspiro[2.5]octan-7-yl, 2-oxa-6-azaspiro[3.4]octan-6-yl, 3-azabicyclo[3.1.0]hexan-3-yl, 8-azabicyclo[3.2.1]octan-3-yl, 8-azabicyclo[3.2.1]oct-2-en-3-yl, 9-azabicyclo[3.3.1]nonan-3-yl, 2,5-diazabicyclo[2.2.1]heptan-2-yl, 1,4-diazabicyclo[3.1.1]heptan-4-yl, 3,6-diazabicyclo[3.2.0]heptan-3-yl, 3,6-diazabicyclo[3.2.0]heptan-6-yl, 2,5-diazabicyclo[2.2.2]octan-2-yl, 1,4-diazabicyclo[3.2.1]octan-4-yl, 3,8-diazabicyclo[3.2.1]octan-3-yl, 1,4-diazabicyclo[3.2.2]nonan-4-yl, 4,7-diazaspiro[2.5]octan-4-yl, 4,7-diazaspiro[2.5]octan-4-yl, 2,6-diazaspiro[3.3]heptan-2-yl, 1,6-diazaspiro[3.4]octan-6-yl, 2,6-diazaspiro[3.4]octan-2-yl, 2,6-diazaspiro[3.4]octan-6-yl, 1,7-diazaspiro[4.4]nonan-1-yl, 1,7-diazaspiro[4.4]nonan-7-yl, 1,7-diazaspiro[3.5]nonane- 7-yl, 2,6-diazaspiro[3.5]nonan-2-yl, 2,6-diazaspiro[3.5]nonan-6-yl, 1,7-diazaspiro[3.5]nonan-7-yl, 2,7-diazaspiro[3.5]nonan-2-yl, 2,7-diazaspiro[3.5]nonan-7-yl, 5,8-diazaspiro[3.5]nonan-8-yl, 2-oxa-5,8-diazaspiro[3.5]nonan-8-yl, 2,7-diaza Zaspiro[4.4]nonan-2-yl, 2,7-diazaspiro[4.5]decan-2-yl, 2,7-diazaspiro[4.5]decan-7-yl, 2,8-diazaspiro[4.5]decan-8-yl, 6,9-diazaspiro[4.5]decan-9-yl, 6-oxa-2,9-diazaspiro[4.5]decan-2-yl, 2,9-diazaspiro[5.5]undecan-9-yl, 4-azadispiro[2.1.2]undecan-2. 5 .3 3 ]decan-9-yl, and 7-azadispiro[5.1.5 8 .3 6 ]hexadecan-15-yl, and, if permitted by available valences, one R b This includes compounds of formula (III) which are substituted with a substituent.

[0436] Another embodiment is where B is azetidin-1-yl, tetrahydrofuran-3-yl, pyrrolidin-1-yl, pyrrolidin-3-yl, piperidin-1-yl, piperidin-3-yl, piperidin-4-yl, piperidin-1-olate-4-yl, piperazin-1-yl, 1,4-diazepin-1-yl, 1,2-dihydropyridin-2-yl, 1,2-dihydropyridin-3-yl, 1,2-dihydropyridin-4-yl, 1,2-dihydropyridin-5-yl, 1,2-dihydropyridin-6-yl, 1,2,5,6-tetrahydropyridine-5-yl, 1,2,5,6-tetrahydropyridine ... -yl, 1,2,3,6-tetrahydropyridin-4-yl, hexahydrocyclopentapyrrol-2(1H)-yl, hexahydropyrrolo[3,2-b]pyrrol-1(2H)-yl, hexahydropyrrolo[3,4-b]pyrrol-1(2H)-yl, hexahydropyrrolo[3,4-c]pyrrol-1(1H)-yl, hexahydropyrrolo[3,4-c]pyrrol-2(1H)-yl, hexahydropyrrolo[3,4-c]pyrrol-5(1H)-yl, octahydro-5H-pyrrolo[3,2-c]pyridin-5-yl, octahydro-6H- Pyrrolo[3,4-b]pyridin-6-yl, hexahydropyrrolo[1,2-a]pyrazin-6(2H)-one, hexahydropyrrolo[1,2-a]pyrazin-2(1H)-yl, hexahydro-1H-cyclobuta[1.2-c:1,4-c′]dipyrrol-2(3H)-yl, octahydropyrrolo[1,2-a]pyrazin-2(1H)-yl, octahydro-2H-pyrido[1,2-a]pyrazin-2-yl, hexahydropyrrolo[3,4-b][1,4]oxazin-6(2H)-yl, 5-azaspiro[2.4]heptan-5-yl, 1- Azaspiro[3.3]heptan-2-yl, 4-azaspiro[2.5]octan-7-yl, 2-oxa-6-azaspiro[3.4]octan-6-yl, 3-azabicyclo[3.1.0]hexan-3-yl, 8-azabicyclo[3.2.1]octan-3-yl, 8-azabicyclo[3.2.1]oct-2-en-3-yl, 9-azabicyclo[3.3.1]nonan-3-yl, 2,5-diazabicyclo[2.2.1]heptan-2-yl, 1,4-diazabicyclo[3.1.1]heptan-4-yl, 3,6-diazabicyclo[3.2.0]heptan-3-yl, 3,6-diazabicyclo[3.2.0]heptan-6-yl, 2,5-diazabicyclo[2.2.2]octan-2-yl, 1,4-diazabicyclo[3.2.1]octan-4-yl, 3,8-diazabicyclo[3.2.1]octan-3-yl, 1,4-diazabicyclo[3.2.2]nonan-4-yl, 4,7-diazaspiro[2.5]octan-4-yl, 4,7-diazaspiro[2.5]octan-4-yl, 2,6-diazaspiro[3.3]heptan-2-yl, 1,6-diazaspiro[3.4]octan-6-yl, 2,6-diazaspiro[3.4]octan-2-yl, 2,6-diazaspiro[3.4]octan-6-yl, 1,7-diazaspiro[4.4]nonan-1-yl, 1,7-diazaspiro[4.4]nonan-7-yl, 1,7-diazaspiro[3.5]nonane- 7-yl, 2,6-diazaspiro[3.5]nonan-2-yl, 2,6-diazaspiro[3.5]nonan-6-yl, 1,7-diazaspiro[3.5]nonan-7-yl, 2,7-diazaspiro[3.5]nonan-2-yl, 2,7-diazaspiro[3.5]nonan-7-yl, 5,8-diazaspiro[3.5]nonan-8-yl, 2-oxa-5,8-diazaspiro[3.5]nonan-8-yl, 2,7-diaza Zaspiro[4.4]nonan-2-yl, 2,7-diazaspiro[4.5]decan-2-yl, 2,7-diazaspiro[4.5]decan-7-yl, 2,8-diazaspiro[4.5]decan-8-yl, 6,9-diazaspiro[4.5]decan-9-yl, 6-oxa-2,9-diazaspiro[4.5]decan-2-yl, 2,9-diazaspiro[5.5]undecan-9-yl, 4-azadispiro[2.1.2]undecan-2. 5 .3 3 ]decan-9-yl, and 7-azadispiro[5.1.5 8 .3 6 ]hexadecan-15-yl, and where available valences permit, two R b This includes compounds of formula (III) which are substituted with a substituent.

[0437] Another embodiment is where B is azetidin-1-yl, tetrahydrofuran-3-yl, pyrrolidin-1-yl, pyrrolidin-3-yl, piperidin-1-yl, piperidin-3-yl, piperidin-4-yl, piperidin-1-olate-4-yl, piperazin-1-yl, 1,4-diazepin-1-yl, 1,2-dihydropyridin-2-yl, 1,2-dihydropyridin-3-yl, 1,2-dihydropyridin-4-yl, 1,2-dihydropyridin-5-yl, 1,2-dihydropyridin-6-yl, 1,2,5,6-tetrahydropyridine-5-yl, 1,2,5,6-tetrahydropyridine ... -yl, 1,2,3,6-tetrahydropyridin-4-yl, hexahydrocyclopentapyrrol-2(1H)-yl, hexahydropyrrolo[3,2-b]pyrrol-1(2H)-yl, hexahydropyrrolo[3,4-b]pyrrol-1(2H)-yl, hexahydropyrrolo[3,4-c]pyrrol-1(1H)-yl, hexahydropyrrolo[3,4-c]pyrrol-2(1H)-yl, hexahydropyrrolo[3,4-c]pyrrol-5(1H)-yl, octahydro-5H-pyrrolo[3,2-c]pyridin-5-yl, octahydro-6H- Pyrrolo[3,4-b]pyridin-6-yl, hexahydropyrrolo[1,2-a]pyrazin-6(2H)-one, hexahydropyrrolo[1,2-a]pyrazin-2(1H)-yl, hexahydro-1H-cyclobuta[1.2-c:1,4-c′]dipyrrol-2(3H)-yl, octahydropyrrolo[1,2-a]pyrazin-2(1H)-yl, octahydro-2H-pyrido[1,2-a]pyrazin-2-yl, hexahydropyrrolo[3,4-b][1,4]oxazin-6(2H)-yl, 5-azaspiro[2.4]heptan-5-yl, 1- Azaspiro[3.3]heptan-2-yl, 4-azaspiro[2.5]octan-7-yl, 2-oxa-6-azaspiro[3.4]octan-6-yl, 3-azabicyclo[3.1.0]hexan-3-yl, 8-azabicyclo[3.2.1]octan-3-yl, 8-azabicyclo[3.2.1]oct-2-en-3-yl, 9-azabicyclo[3.3.1]nonan-3-yl, 2,5-diazabicyclo[2.2.1]heptan-2-yl, 1,4-diazabicyclo[3.1.1]heptan-4-yl, 3,6-diazabicyclo[3.2.0]heptan-3-yl, 3,6-diazabicyclo[3.2.0]heptan-6-yl, 2,5-diazabicyclo[2.2.2]octan-2-yl, 1,4-diazabicyclo[3.2.1]octan-4-yl, 3,8-diazabicyclo[3.2.1]octan-3-yl, 1,4-diazabicyclo[3.2.2]nonan-4-yl, 4,7-diazaspiro[2.5]octan-4-yl, 4,7-diazaspiro[2.5]octan-4-yl, 2,6-diazaspiro[3.3]heptan-2-yl, 1,6-diazaspiro[3.4]octan-6-yl, 2,6-diazaspiro[3.4]octan-2-yl, 2,6-diazaspiro[3.4]octan-6-yl, 1,7-diazaspiro[4.4]nonan-1-yl, 1,7-diazaspiro[4.4]nonan-7-yl, 1,7-diazaspiro[3.5]nonane- 7-yl, 2,6-diazaspiro[3.5]nonan-2-yl, 2,6-diazaspiro[3.5]nonan-6-yl, 1,7-diazaspiro[3.5]nonan-7-yl, 2,7-diazaspiro[3.5]nonan-2-yl, 2,7-diazaspiro[3.5]nonan-7-yl, 5,8-diazaspiro[3.5]nonan-8-yl, 2-oxa-5,8-diazaspiro[3.5]nonan-8-yl, 2,7-diaza Zaspiro[4.4]nonan-2-yl, 2,7-diazaspiro[4.5]decan-2-yl, 2,7-diazaspiro[4.5]decan-7-yl, 2,8-diazaspiro[4.5]decan-8-yl, 6,9-diazaspiro[4.5]decan-9-yl, 6-oxa-2,9-diazaspiro[4.5]decan-2-yl, 2,9-diazaspiro[5.5]undecan-9-yl, 4-azadispiro[2.1.2]undecan-2. 5 .3 3 ]decan-9-yl, and 7-azadispiro[5.1.5 8 .3 6 ]hexadecan-15-yl, and where available valences permit, three R b This includes compounds of formula (III) which are substituted with a substituent.

[0438] Another embodiment is where B is azetidin-1-yl, tetrahydrofuran-3-yl, pyrrolidin-1-yl, pyrrolidin-3-yl, piperidin-1-yl, piperidin-3-yl, piperidin-4-yl, piperidin-1-olate-4-yl, piperazin-1-yl, 1,4-diazepin-1-yl, 1,2-dihydropyridin-2-yl, 1,2-dihydropyridin-3-yl, 1,2-dihydropyridin-4-yl, 1,2-dihydropyridin-5-yl, 1,2-dihydropyridin-6-yl, 1,2,5,6-tetrahydropyridine-5-yl, 1,2,5,6-tetrahydropyridine ... -yl, 1,2,3,6-tetrahydropyridin-4-yl, hexahydrocyclopentapyrrol-2(1H)-yl, hexahydropyrrolo[3,2-b]pyrrol-1(2H)-yl, hexahydropyrrolo[3,4-b]pyrrol-1(2H)-yl, hexahydropyrrolo[3,4-c]pyrrol-1(1H)-yl, hexahydropyrrolo[3,4-c]pyrrol-2(1H)-yl, hexahydropyrrolo[3,4-c]pyrrol-5(1H)-yl, octahydro-5H-pyrrolo[3,2-c]pyridin-5-yl, octahydro-6H- Pyrrolo[3,4-b]pyridin-6-yl, hexahydropyrrolo[1,2-a]pyrazin-6(2H)-one, hexahydropyrrolo[1,2-a]pyrazin-2(1H)-yl, hexahydro-1H-cyclobuta[1.2-c:1,4-c′]dipyrrol-2(3H)-yl, octahydropyrrolo[1,2-a]pyrazin-2(1H)-yl, octahydro-2H-pyrido[1,2-a]pyrazin-2-yl, hexahydropyrrolo[3,4-b][1,4]oxazin-6(2H)-yl, 5-azaspiro[2.4]heptan-5-yl, 1- Azaspiro[3.3]heptan-2-yl, 4-azaspiro[2.5]octan-7-yl, 2-oxa-6-azaspiro[3.4]octan-6-yl, 3-azabicyclo[3.1.0]hexan-3-yl, 8-azabicyclo[3.2.1]octan-3-yl, 8-azabicyclo[3.2.1]oct-2-en-3-yl, 9-azabicyclo[3.3.1]nonan-3-yl, 2,5-diazabicyclo[2.2.1]heptan-2-yl, 1,4-diazabicyclo[3.1.1]heptan-4-yl, 3,6-diazabicyclo[3.2.0]heptan-3-yl, 3,6-diazabicyclo[3.2.0]heptan-6-yl, 2,5-diazabicyclo[2.2.2]octan-2-yl, 1,4-diazabicyclo[3.2.1]octan-4-yl, 3,8-diazabicyclo[3.2.1]octan-3-yl, 1,4-diazabicyclo[3.2.2]nonan-4-yl, 4,7-diazaspiro[2.5]octan-4-yl, 4,7-diazaspiro[2.5]octan-4-yl, 2,6-diazaspiro[3.3]heptan-2-yl, 1,6-diazaspiro[3.4]octan-6-yl, 2,6-diazaspiro[3.4]octan-2-yl, 2,6-diazaspiro[3.4]octan-6-yl, 1,7-diazaspiro[4.4]nonan-1-yl, 1,7-diazaspiro[4.4]nonan-7-yl, 1,7-diazaspiro[3.5]nonane- 7-yl, 2,6-diazaspiro[3.5]nonan-2-yl, 2,6-diazaspiro[3.5]nonan-6-yl, 1,7-diazaspiro[3.5]nonan-7-yl, 2,7-diazaspiro[3.5]nonan-2-yl, 2,7-diazaspiro[3.5]nonan-7-yl, 5,8-diazaspiro[3.5]nonan-8-yl, 2-oxa-5,8-diazaspiro[3.5]nonan-8-yl, 2,7-diaza Zaspiro[4.4]nonan-2-yl, 2,7-diazaspiro[4.5]decan-2-yl, 2,7-diazaspiro[4.5]decan-7-yl, 2,8-diazaspiro[4.5]decan-8-yl, 6,9-diazaspiro[4.5]decan-9-yl, 6-oxa-2,9-diazaspiro[4.5]decan-2-yl, 2,9-diazaspiro[5.5]undecan-9-yl, 4-azadispiro[2.1.2]undecan-2. 5 .3 3 ]decan-9-yl, and 7-azadispiro[5.1.5 8 .3 6 ]hexadecan-15-yl, and, where available valences permit, four R b This includes compounds of formula (III) which are substituted with a substituent.

[0439] Another embodiment is where B is azetidin-1-yl, tetrahydrofuran-3-yl, pyrrolidin-1-yl, pyrrolidin-3-yl, piperidin-1-yl, piperidin-3-yl, piperidin-4-yl, piperidin-1-olate-4-yl, piperazin-1-yl, 1,4-diazepin-1-yl, 1,2-dihydropyridin-2-yl, 1,2-dihydropyridin-3-yl, 1,2-dihydropyridin-4-yl, 1,2-dihydropyridin-5-yl, 1,2-dihydropyridin-6-yl, 1,2,5,6-tetrahydropyridine-5-yl, 1,2,5,6-tetrahydropyridine ... -yl, 1,2,3,6-tetrahydropyridin-4-yl, hexahydrocyclopentapyrrol-2(1H)-yl, hexahydropyrrolo[3,2-b]pyrrol-1(2H)-yl, hexahydropyrrolo[3,4-b]pyrrol-1(2H)-yl, hexahydropyrrolo[3,4-c]pyrrol-1(1H)-yl, hexahydropyrrolo[3,4-c]pyrrol-2(1H)-yl, hexahydropyrrolo[3,4-c]pyrrol-5(1H)-yl, octahydro-5H-pyrrolo[3,2-c]pyridin-5-yl, octahydro-6H- Pyrrolo[3,4-b]pyridin-6-yl, hexahydropyrrolo[1,2-a]pyrazin-6(2H)-one, hexahydropyrrolo[1,2-a]pyrazin-2(1H)-yl, hexahydro-1H-cyclobuta[1.2-c:1,4-c′]dipyrrol-2(3H)-yl, octahydropyrrolo[1,2-a]pyrazin-2(1H)-yl, octahydro-2H-pyrido[1,2-a]pyrazin-2-yl, hexahydropyrrolo[3,4-b][1,4]oxazin-6(2H)-yl, 5-azaspiro[2.4]heptan-5-yl, 1- Azaspiro[3.3]heptan-2-yl, 4-azaspiro[2.5]octan-7-yl, 2-oxa-6-azaspiro[3.4]octan-6-yl, 3-azabicyclo[3.1.0]hexan-3-yl, 8-azabicyclo[3.2.1]octan-3-yl, 8-azabicyclo[3.2.1]oct-2-en-3-yl, 9-azabicyclo[3.3.1]nonan-3-yl, 2,5-diazabicyclo[2.2.1]heptan-2-yl, 1,4-diazabicyclo[3.1.1]heptan-4-yl, 3,6-diazabicyclo[3.2.0]heptan-3-yl, 3,6-diazabicyclo[3.2.0]heptan-6-yl, 2,5-diazabicyclo[2.2.2]octan-2-yl, 1,4-diazabicyclo[3.2.1]octan-4-yl, 3,8-diazabicyclo[3.2.1]octan-3-yl, 1,4-diazabicyclo[3.2.2]nonan-4-yl, 4,7-diazaspiro[2.5]octan-4-yl, 4,7-diazaspiro[2.5]octan-4-yl, 2,6-diazaspiro[3.3]heptan-2-yl, 1,6-diazaspiro[3.4]octan-6-yl, 2,6-diazaspiro[3.4]octan-2-yl, 2,6-diazaspiro[3.4]octan-6-yl, 1,7-diazaspiro[4.4]nonan-1-yl, 1,7-diazaspiro[4.4]nonan-7-yl, 1,7-diazaspiro[3.5]nonane- 7-yl, 2,6-diazaspiro[3.5]nonan-2-yl, 2,6-diazaspiro[3.5]nonan-6-yl, 1,7-diazaspiro[3.5]nonan-7-yl, 2,7-diazaspiro[3.5]nonan-2-yl, 2,7-diazaspiro[3.5]nonan-7-yl, 5,8-diazaspiro[3.5]nonan-8-yl, 2-oxa-5,8-diazaspiro[3.5]nonan-8-yl, 2,7-diaza Zaspiro[4.4]nonan-2-yl, 2,7-diazaspiro[4.5]decan-2-yl, 2,7-diazaspiro[4.5]decan-7-yl, 2,8-diazaspiro[4.5]decan-8-yl, 6,9-diazaspiro[4.5]decan-9-yl, 6-oxa-2,9-diazaspiro[4.5]decan-2-yl, 2,9-diazaspiro[5.5]undecan-9-yl, 4-azadispiro[2.1.2]undecan-2. 5 .3 3 ]decan-9-yl, and 7-azadispiro[5.1.5 8 .3 6 ]hexadecan-15-yl, and where available valences permit, five R b This includes compounds of formula (III) which are substituted with a substituent.

[0440] Another embodiment is where B is heterocyclyl selected from piperidin-4-yl and piperazin-1-yl and, where available valences permit, 1, 2, 3, 4 or 5 R b The compounds of formula (III) include those which may be substituted with a substituent.

[0441] Another embodiment includes compounds of formula (III) where B is unsubstituted heterocyclyl selected from piperidin-4-yl and piperazin-1-yl.

[0442] Another embodiment is where B is heterocyclyl selected from piperidin-4-yl and piperazin-1-yl, and where available valences permit, one R b This includes compounds of formula (III) which are substituted with a substituent.

[0443] Another embodiment is where B is heterocyclyl selected from piperidin-4-yl and piperazin-1-yl, and where available valences permit, two R b This includes compounds of formula (III) which are substituted with a substituent.

[0444] Another embodiment is where B is heterocyclyl selected from piperidin-4-yl and piperazin-1-yl, and where available valences permit, three R b This includes compounds of formula (III) which are substituted with a substituent.

[0445] Another embodiment is where B is heterocyclyl selected from piperidin-4-yl and piperazin-1-yl, and where available valences permit, four R b This includes compounds of formula (III) which are substituted with a substituent.

[0446] Another embodiment is where B is heterocyclyl selected from piperidin-4-yl and piperazin-1-yl, and where available valences permit, five R b This includes compounds of formula (III) which are substituted with a substituent.

[0447] Another embodiment is where B is piperidin-4-yl and, where available valences allow, four R b This includes compounds of formula (III) which are substituted with a substituent.

[0448] Another embodiment is where B is heterocyclyl selected from piperazin-4-yl and, where available valences permit, two R b This includes compounds of formula (III) which are substituted with a substituent.

[0449] Another embodiment includes compounds of formula (III) where B is heterocyclyl containing at least one asymmetric carbon atom having the (R) configuration.

[0450] Another embodiment includes compounds of formula (III) where B is heterocyclyl containing at least one asymmetric carbon atom having an (S) configuration.

[0451] In one embodiment, R b But halogen, C 1-4 Alkyl, Amino, C 1-4 Alkyl-amino, (C 1-4 Alkyl) 2 -amino, and C 3-6 cycloalkyl.

[0452] Another aspect is R b is selected from methyl, ethyl, propyl, isopropyl, butyl, and tert-butyl; 1-4 This includes compounds of formula (III) wherein:

[0453] Another aspect is R b is methyl.

[0454] In one embodiment, R 1 Heteroaryl, heterocyclyl, phenyl, heteroaryl-C 1-4 Alkyl, Heteroaryl-C 2-4Alkenyl, Heteroaryl-amino, and Heteroaryl-C 1-4 alkyl-amino, Heteroaryl is a 3-7 membered monocyclic or 6-10 membered bicyclic ring system having 1, 2, 3, or 4 heteroatom ring members independently selected from N, O, or S; Heterocyclyl is a saturated or partially unsaturated 3- to 7-membered monocyclic, 6- to 10-membered bicyclic or 13- to 16-membered polycyclic ring system having 1, 2 or 3 heteroatom ring members independently selected from N, O or S; Each example of phenyl, heteroaryl, or heterocyclyl may have one or two R 1a It may be substituted with a substituent.

[0455] Another aspect is R 1 Heteroaryl, heterocyclyl, phenyl, heteroaryl-C 1-4 Alkyl, Heteroaryl-C 2-4 Alkenyl, Heteroaryl-amino, and Heteroaryl-C 1-4 alkyl-amino, Heteroaryl is a 3-7 membered monocyclic or 6-10 membered bicyclic ring system having 1, 2, 3, or 4 heteroatom ring members independently selected from N, O, or S; Heterocyclyl is a saturated or partially unsaturated 3- to 7-membered monocyclic, 6- to 10-membered bicyclic or 13- to 16-membered polycyclic ring system having 1, 2 or 3 heteroatom ring members independently selected from N, O or S; Each instance of phenyl, heteroaryl or heterocyclyl is unsubstituted.

[0456] Another aspect is R 1 Heteroaryl, heterocyclyl, phenyl, heteroaryl-C 1-4 Alkyl, Heteroaryl-C 2-4 Alkenyl, Heteroaryl-amino, and Heteroaryl-C 1-4alkyl-amino, Heteroaryl is a 3-7 membered monocyclic or 6-10 membered bicyclic ring system having 1, 2, 3, or 4 heteroatom ring members independently selected from N, O, or S; Heterocyclyl is a saturated or partially unsaturated 3- to 7-membered monocyclic, 6- to 10-membered bicyclic or 13- to 16-membered polycyclic ring system having 1, 2 or 3 heteroatom ring members independently selected from N, O or S; Each example of phenyl, heteroaryl, or heterocyclyl may be substituted with one R 1a It is substituted with a substituent.

[0457] Another aspect is R 1 is heteroaryl, Heteroaryl is a 3-7 membered monocyclic or 6-10 membered bicyclic ring system having 1, 2, 3, or 4 heteroatom ring members independently selected from N, O, or S, and heteroaryl may contain, where available valences permit, one or two R 1a It may be substituted with a substituent.

[0458] Another aspect is R 1 is heteroaryl, Heteroaryl is a 3-7 membered monocyclic or 6-10 membered bicyclic ring system having 1, 2, 3, or 4 heteroatom ring members independently selected from N, O, or S, and heteroaryl is unsubstituted.

[0459] Another aspect is R 1 is heteroaryl, Heteroaryl is a 3-7 membered monocyclic or 6-10 membered bicyclic ring system having 1, 2, 3, or 4 heteroatom ring members independently selected from N, O, or S, and heteroaryl may contain, where available valences permit, one R 1a It is substituted with a substituent.

[0460] Another aspect is R 1thienyl, 1H-pyrazolyl, 1H-imidazolyl, 1,3-thiazolyl, oxazolyl, 1,2,4-oxadiazolyl, 1,3,4-oxadiazolyl, 1,2,4-thiadiazolyl, 1H-1,2,3-triazolyl, 2H-1,2,3-triazolyl, 1H-1,2,4-triazolyl, 1H-tetrazolyl, 2H-tetrazolyl, pyridinyl, pyridin-2(1H)-one-yl, pyrazinyl, pyrimidinyl, pyrimidin-4(3H)-one-yl, pyridazinyl, pyridazin-3(2H)-one-yl, 1,2,4-triazinyl, 1, 3,5-Triazinyl, 1H-Indolyl, 1H-Indazolyl, 2H-Indazolyl, Indolizinyl, Benzofuranyl, Benzothienyl, 1H-Benzimidazolyl, 1,3-Benzoxazolyl, 1,3-Benzothiazolyl, 1,3-Benzodioxolyl, 1,2,3-Benzotriazolyl, 9H-Purinyl, Furo[3,2-b]pyridinyl, Furo[3,2-c]pyridinyl, Furo[2,3-c]pyridinyl, 1,3-Oxazolo[5,4-b]pyridinyl, Thieno[3,2-c]pyridinyl, Thieno[2,3-d]pyrimidinyl, 1H-Pyrrolo[ 2,3-b]pyridinyl, 1H-pyrrolo[2,3-c]pyridinyl, pyrrolo[1,2-a]pyrimidinyl, pyrrolo[1,2-a]pyrazinyl, pyrrolo[1,2-b]pyridazinyl, pyrazolo[1,5-a]pyridinyl, pyrazolo[1,5-a]pyrimidinyl, pyrazolo[1,5-a]pyrazinyl, 1H-pyrazolo[3,4-b]pyridinyl, 1H-pyrazolo[3,4-b]pyrazinyl, 1H-pyrazolo[3,4-c]pyridinyl, 1H-pyrazolo[4,3-b]pyridinyl, 1H-pyrazolo[4,3-d]pyrimidinyl, 2H-pyrazolo[4,3-b]pyridinyl Lysinyl, 2H-pyrazolo[4,3-c]pyridinyl, 5H-pyrrolo[2,3-b]pyrazinyl, imidazo[1,2-a]pyridinyl, imidazo[1,2-a]pyrazinyl, imidazo[1,2-a]pyrimidinyl, imidazo[1,2-b]pyridazinyl, imidazo[1,2-c]pyrimidinyl, 1H-imidazo[4,5-b]pyridinyl, 3H-imidazo[4,5-b]pyridinyl, imidazo[2,1-b][1,3]thiazolyl, imidazo[2,1-b][1,3,4]thiadiazolyl, [1,3]oxazolo[4,5-b]pyridinyl, [1,2,3]triazolo[1,5-a]pyridinyl, 1H-[1,2,3]triazolo[4,5-b]pyridinyl, 2H-[1,2,3]triazolo[4,5-b]pyridinyl, 3H-[1,2,3]triazolo[4,5-b]pyridinyl, [1,2,4]triazolo[1,5-a]pyridinyl, [1,2,4]triazolo[1,5-a]pyridinyl, [1,2,4]triazolo[1,5-a]pyrazinyl, [1,2,4]triazolo[4,3-a]pyridinyl, tetrazolo[1,5-a]pyridinyl, tetrazolo[1,5-b]pyridazinyl, quinolinyl, isoquinolinyl, and quinoxalinyl, where available valences permit, one or two R, 1a The compounds of formula (III) include those which may be substituted with a substituent.

[0461] Another aspect is R 1thienyl, 1H-pyrazolyl, 1H-imidazolyl, 1,3-thiazolyl, oxazolyl, 1,2,4-oxadiazolyl, 1,3,4-oxadiazolyl, 1,2,4-thiadiazolyl, 1H-1,2,3-triazolyl, 2H-1,2,3-triazolyl, 1H-1,2,4-triazolyl, 1H-tetrazolyl, 2H-tetrazolyl, pyridinyl, pyridin-2(1H)-one-yl, pyrazinyl, pyrimidinyl, pyrimidin-4(3H)-one-yl, pyridazinyl, pyridazin-3(2H)-one-yl, 1,2,4-triazinyl, 1, 3,5-Triazinyl, 1H-Indolyl, 1H-Indazolyl, 2H-Indazolyl, Indolizinyl, Benzofuranyl, Benzothienyl, 1H-Benzimidazolyl, 1,3-Benzoxazolyl, 1,3-Benzothiazolyl, 1,3-Benzodioxolyl, 1,2,3-Benzotriazolyl, 9H-Purinyl, Furo[3,2-b]pyridinyl, Furo[3,2-c]pyridinyl, Furo[2,3-c]pyridinyl, 1,3-Oxazolo[5,4-b]pyridinyl, Thieno[3,2-c]pyridinyl, Thieno[2,3-d]pyrimidinyl, 1H-Pyrrolo[ 2,3-b]pyridinyl, 1H-pyrrolo[2,3-c]pyridinyl, pyrrolo[1,2-a]pyrimidinyl, pyrrolo[1,2-a]pyrazinyl, pyrrolo[1,2-b]pyridazinyl, pyrazolo[1,5-a]pyridinyl, pyrazolo[1,5-a]pyrimidinyl, pyrazolo[1,5-a]pyrazinyl, 1H-pyrazolo[3,4-b]pyridinyl, 1H-pyrazolo[3,4-b]pyrazinyl, 1H-pyrazolo[3,4-c]pyridinyl, 1H-pyrazolo[4,3-b]pyridinyl, 1H-pyrazolo[4,3-d]pyrimidinyl, 2H-pyrazolo[4,3-b]pyridinyl Lysinyl, 2H-pyrazolo[4,3-c]pyridinyl, 5H-pyrrolo[2,3-b]pyrazinyl, imidazo[1,2-a]pyridinyl, imidazo[1,2-a]pyrazinyl, imidazo[1,2-a]pyrimidinyl, imidazo[1,2-b]pyridazinyl, imidazo[1,2-c]pyrimidinyl, 1H-imidazo[4,5-b]pyridinyl, 3H-imidazo[4,5-b]pyridinyl, imidazo[2,1-b][1,3]thiazolyl, imidazo[2,1-b][1,3,4]thiadiazolyl, [1,3]oxazolo[4,5-b]pyridinyl, [1,2,3]triazolo[1,5-a]pyridinyl, 1H-[1,2,3]triazolo[4,5-b]pyridinyl, 2H-[1,2,3]triazolo[4,5-b]pyridinyl, 3H-[1,2,3]triazolo[4,5-b]pyridinyl, [1,2,4]triazolo[1,5-a]pyridinyl, [1,2,4]triazolo[1,5-a]pyridinyl, [1,2,4...

Claims

1. A compound of formula (I), formula (II), or formula (III), or a form thereof, wherein the form of the compound is selected from the group consisting of a salt, a hydrate, a solvate, a racemate, an enantiomer, a diastereoisomer, and a tautomer thereof. 【Chemistry 1】 (In the formula, X is O, NR x and a bond; R x is hydrogen and C 1-4 is selected from the group consisting of alkyl, B is heterocyclyl; Heterocyclyl is a saturated or partially unsaturated 3- to 7-membered monocyclic, 6- to 10-membered bicyclic, or 13- to 16-membered polycyclic ring system having 1, 2, or 3 heteroatom ring members independently selected from N, O, or S, and, where permitted by available valences, 1, 2, 3, 4, or 5 R b may be substituted with a substituent; R b But halogen, C 1-4 Alkyl, Amino, C 1-4 Alkyl-amino, (C 1-4 Alkyl) 2 -amino, and C 3-6 cycloalkyl; R 1 is heteroaryl, heterocyclyl, phenyl, heteroaryl-C 1-4 Alkyl, Heteroaryl-C 2-4 Alkenyl, heteroaryl-amino, and heteroaryl-C 1-4 alkyl-amino; heteroaryl is a 3-7 membered monocyclic or 6-10 membered bicyclic ring system having 1, 2, 3, or 4 heteroatom ring members independently selected from N, O, or S; heterocyclyl is a saturated or partially unsaturated 3- to 7-membered monocyclic, 6- to 10-membered bicyclic or 13- to 16-membered polycyclic ring system having 1, 2 or 3 heteroatom ring members independently selected from N, O or S; Each instance of phenyl, heteroaryl, or heterocyclyl may, where available valences permit, have one or two R 1a may be substituted with a substituent; R 1a is halogen, hydroxyl, cyano, C 1-4 Alkyl, Deuterium-C 1-4 Alkyl, halo-C 1-4 Alkyl, Amino, C 1-4 Alkyl-amino, (C 1-4 Alkyl) 2 - Amino, C 1-4 Alkoxy, Deuterium-C 1-4 Alkoxy, and halo-C 1-4 alkoxy)

2. 2. The compound or a form thereof according to claim 1, wherein the compound is a compound of formula (I). 【Chemistry 2】

3. 3. The compound or a form thereof according to claim 1 or 2, wherein X is selected from the group consisting of O and a bond.

4. B is selected from the group consisting of pyrrolidinyl, piperidinyl, piperidin-1-olate-yl, piperazinyl, 4-azaspiro[2.5]octanyl, 8-azabicyclo[3.2.1]octanyl, 2,5-diazabicyclo[2.2.1]heptanyl, 1,6-diazaspiro[3.4]octanyl, 2-oxa-5,8-diazaspiro[3.5]nonanyl, and 4-azadispiro[2.1.2]octanyl. 5 .3 3 ]decanyl, where available valences permit, one, two, three, four or five R b 3. The compound according to claim 1 or 2, or a form thereof, which may be substituted with a substituent.

5. R 1 1H-pyrazolyl, 1H-imidazolyl, 1,3-thiazolyl, oxazolyl, 1H-1,2,3-triazolyl, 2H-1,2,3-triazolyl, 1H-1,2,4-triazolyl, pyridinyl, pyridin-2(1H)-one-yl, pyrimidin-4(3H)-one-yl, pyridazinyl, 1H-indazolyl, 2H-indazolyl, 1,3-benzoxazolyl, pyrrolo[1,2-a]pyrazinyl, imidazo[1,2- 3. The compound or form thereof according to claim 1 or 2, wherein the heteroaryl is selected from the group consisting of 2H-[1,2,3]triazolo[4,5-b]pyridinyl, [1,2,4]triazolo[1,5-a]pyridinyl, imidazo[1,2-a]pyrazinyl, imidazo[1,2-a]pyrimidinyl, imidazo[1,2-b]pyridazinyl, 2H-[1,2,3]triazolo[4,5-b]pyridinyl, [1,2,4]triazolo[1,5-a]pyridinyl, and [1,2,4]triazolo[1,5-a]pyrazinyl.

6. R 1 The compound or a form thereof according to claim 5, wherein is a heteroaryl selected from the group consisting of 1H-pyrazolyl and 2H-indazolyl.

7. R 1a But halogen, cyano, C 1-4 Alkyl, Deuterium-C 1-4 Alkyl, halo-C 1-4 Alkyl, C 1-4 Alkoxy, and deuterium-C 1-4 3. The compound or a form thereof according to claim 1 or 2, wherein said compound or a form thereof is selected from the group consisting of alkoxy.

8. R 1a But halogen, C 1-4 Alkyl, and C 1-4 8. The compound or a form thereof according to claim 7, selected from the group consisting of alkoxy.

9. 5-(1H-pyrazol-4-yl)-2-{6-[(2,2,6,6-tetramethylpiperidin-4-yl)oxy]pyridazin-3-yl}pyridin-3-ol; 2-{6-[methyl(2,2,6,6-tetramethylpiperidin-4-yl)amino]pyridazin-3-yl}-5-(1H-pyrazol-4-yl)pyridin-3-ol; 5-[1-( 2 H 3 ) methyl-1H-pyrazol-4-yl]-2-{6-[(2,2,6,6-tetramethylpiperidin-4-yl)oxy]pyridazin-3-yl}pyridin-3-ol; 5-(1-methyl-1H-pyrazol-3-yl)-2-{6-[(2,2,6,6-tetramethylpiperidin-4-yl)oxy]pyridazin-3-yl}pyridin-3-ol; 5-(1H-imidazol-1-yl)-2-{6-[(2,2,6,6-tetramethylpiperidin-4-yl)oxy]pyridazin-3-yl}pyridin-3-ol; 2-(6-{[(3R,4S)-3-fluoro-2,2,6,6-tetramethylpiperidin-4-yl]oxy}pyridazin-3-yl)-5-(1H-pyrazol-4-yl)pyridin-3-ol; 2-(6-{[(3S,4R)-3-fluoro-2,2,6,6-tetramethylpiperidin-4-yl]oxy}pyridazin-3-yl)-5-(1H-pyrazol-4-yl)pyridin-3-ol; 2-(6-{[(3R,4S)-3-fluoro-2,2,6,6-tetramethylpiperidin-4-yl]oxy}pyridazin-3-yl)-5-(1-methyl-1H-pyrazol-3-yl)pyridin-3-ol; 2-(6-{[(3S,4R)-3-fluoro-2,2,6,6-tetramethylpiperidin-4-yl]oxy}pyridazin-3-yl)-5-(1-methyl-1H-pyrazol-3-yl)pyridin-3-ol; 2-(6-{[(3R,4S)-3-fluoro-2,2,6,6-tetramethylpiperidin-4-yl]amino}pyridazin-3-yl)-5-(1H-pyrazol-4-yl)pyridin-3-ol; 2-(6-{[(3R,4S)-3-fluoro-2,2,6,6-tetramethylpiperidin-4-yl]oxy}pyridazin-3-yl)-5-(1H-imidazol-1-yl)pyridin-3-ol; 2-(6-{[(3S,4R)-3-fluoro-2,2,6,6-tetramethylpiperidin-4-yl]oxy}pyridazin-3-yl)-5-(1H-imidazol-1-yl)pyridin-3-ol; 5-(1,3-oxazol-2-yl)-2-{6-[(2,2,6,6-tetramethylpiperidin-4-yl)oxy]pyridazin-3-yl}pyridin-3-ol; 2-(6-{[(3R,4S)-3-fluoro-2,2,6,6-tetramethylpiperidin-4-yl]oxy}pyridazin-3-yl)-5-(2H-1,2,3-triazol-2-yl)pyridin-3-ol; 2-(6-{[(3S,4R)-3-fluoro-2,2,6,6-tetramethylpiperidin-4-yl]oxy}pyridazin-3-yl)-5-(2H-1,2,3-triazol-2-yl)pyridin-3-ol; 2-(6-{[(3R,4S)-3-fluoro-2,2,6,6-tetramethylpiperidin-4-yl]oxy}pyridazin-3-yl)-5-(1,3-oxazol-2-yl)pyridin-3-ol; 2-(6-{[(3S,4R)-3-fluoro-2,2,6,6-tetramethylpiperidin-4-yl]oxy}pyridazin-3-yl)-5-(1,3-oxazol-2-yl)pyridin-3-ol; 5-(1-methyl-1H-pyrazol-3-yl)-2-{6-[methyl(2,2,6,6-tetramethylpiperidin-4-yl)amino]pyridazin-3-yl}pyridin-3-ol; 2-{6-[methyl(2,2,6,6-tetramethylpiperidin-4-yl)amino]pyridazin-3-yl}-5-(1,3-oxazol-2-yl)pyridin-3-ol; 5-(1H-imidazol-1-yl)-2-{6-[methyl(2,2,6,6-tetramethylpiperidin-4-yl)amino]pyridazin-3-yl}pyridin-3-ol; 2-(6-{[(3S,4S)-3-fluoro-2,2,6,6-tetramethylpiperidin-4-yl]amino}pyridazin-3-yl)-5-(1H-pyrazol-3-yl)pyridin-3-ol; 2-(6-{[(3R,4R)-3-fluoro-2,2,6,6-tetramethylpiperidin-4-yl]amino}pyridazin-3-yl)-5-(1H-pyrazol-3-yl)pyridin-3-ol; 2-{6-[(3R)-(tert-butylamino)pyrrolidin-1-yl]pyridazin-3-yl}-5-(1-methyl-1H-pyrazol-3-yl)pyridin-3-ol; 2-{6-[(3S)-(tert-butylamino)pyrrolidin-1-yl]pyridazin-3-yl}-5-(1-methyl-1H-pyrazol-3-yl)pyridin-3-ol; 2-{6-[(3R)-(tert-butylamino)pyrrolidin-1-yl]pyridazin-3-yl}-5-(1H-pyrazol-4-yl)pyridin-3-ol; 2-{6-[(3S)-(tert-butylamino)pyrrolidin-1-yl]pyridazin-3-yl}-5-(1H-pyrazol-4-yl)pyridin-3-ol; 2-(6-{[(3R,4R)-3-fluoro-2,2,6,6-tetramethylpiperidin-4-yl]amino}pyridazin-3-yl)-5-[1-( 2 H 3 ) methyl-1H-pyrazol-4-yl]pyridin-3-ol; 2-(6-{[(3S,4S)-3-fluoro-2,2,6,6-tetramethylpiperidin-4-yl]amino}pyridazin-3-yl)-5-[1-( 2 H 3 ) methyl-1H-pyrazol-4-yl]pyridin-3-ol; 2-{6-[(2,2,6,6-tetramethylpiperidin-4-yl)oxy]pyridazin-3-yl}-5-(2H-1,2,3-triazol-2-yl)pyridin-3-ol; 2-{6-[(5,5-dimethyl-4-azaspiro[2.5]octan-7-yl)oxy]pyridazin-3-yl}-5-(2H-1,2,3-triazol-2-yl)pyridin-3-ol; 5-(5-fluoro-1H-pyrazol-4-yl)-2-(6-{[(3R,4S)-3-fluoro-2,2,6,6-tetramethylpiperidin-4-yl]oxy}pyridazin-3-yl)pyridin-3-ol; 5-(5-fluoro-1H-pyrazol-4-yl)-2-(6-{[(3S,4R)-3-fluoro-2,2,6,6-tetramethylpiperidin-4-yl]oxy}pyridazin-3-yl)pyridin-3-ol; 2-{6-[(3R)-3-(tert-butylamino)pyrrolidin-1-yl]pyridazin-3-yl}-5-[1-( 2 H 3 ) methyl-1H-pyrazol-4-yl]pyridin-3-ol; 2-{6-[(3R)-3-(tert-butylamino)pyrrolidin-1-yl]pyridazin-3-yl}-5-(2H-1,2,3-triazol-2-yl)pyridin-3-ol; 2-(6-{[(3R,4R)-3-fluoro-2,2,6,6-tetramethylpiperidin-4-yl]amino}pyridazin-3-yl)-5-{6-[( 2 H 3 ) methyloxy]pyrimidin-4-yl}pyridin-3-ol; 2-{6-[(5,5-dimethyl-4-azaspiro[2.5]octan-7-yl)oxy]pyridazin-3-yl}-5-(5-fluoro-1H-pyrazol-4-yl)pyridin-3-ol; 2-{6-[(5,5-dimethyl-4-azaspiro[2.5]octan-7-yl)oxy]pyridazin-3-yl}-5-(1H-pyrazol-4-yl)pyridin-3-ol; 2-{6-[(5,5-dimethyl-4-azaspiro[2.5]octan-7-yl)oxy]pyridazin-3-yl}-5-(1,3-oxazol-2-yl)pyridin-3-ol; 2-{6-[3-(tert-butylamino)pyrrolidin-1-yl]pyridazin-3-yl}-5-[1-( 2 H 3 ) methyl-1H-pyrazol-4-yl]pyridin-3-ol; 2-{6-[(3R)-3-(tert-butylamino)pyrrolidin-1-yl]pyridazin-3-yl}-5-(6-methoxypyrimidin-4-yl)pyridin-3-ol; 2-{6-[(4-azadispiro[2.1.2 5 .3 3 ]decan-9-yl)oxy]pyridazin-3-yl}-5-(1H-pyrazol-4-yl)pyridin-3-ol; 2-(6-{[(1R,3s,5S)-1,5-dimethyl-8-azabicyclo[3.2.1]octan-3-yl]oxy}pyridazin-3-yl)-5-(2H-1,2,3-triazol-2-yl)pyridin-3-ol; 2-(6-{[(1S,3r,5R)-1,5-dimethyl-8-azabicyclo[3.2.1]octan-3-yl]oxy}pyridazin-3-yl)-5-(2H-1,2,3-triazol-2-yl)pyridin-3-ol; 2-(6-{[(1R,3s,5S)-1,5-dimethyl-8-azabicyclo[3.2.1]octan-3-yl]oxy}pyridazin-3-yl)-5-[1-( 2 H 3 ) methyl-1H-pyrazol-4-yl]pyridin-3-ol; 2-(6-{[(1S,3r,5R)-1,5-dimethyl-8-azabicyclo[3.2.1]octan-3-yl]oxy}pyridazin-3-yl)-5-[1-( 2 H 3 ) methyl-1H-pyrazol-4-yl]pyridin-3-ol; 5-[6-(6-{[(3R,4S)-3-fluoro-2,2,6,6-tetramethylpiperidin-4-yl]oxy}pyridazin-3-yl)-5-hydroxypyridin-3-yl]-2-methyl-2H-indazole-7-carbonitrile; 5-[6-(6-{[(3S,4R)-3-fluoro-2,2,6,6-tetramethylpiperidin-4-yl]oxy}pyridazin-3-yl)-5-hydroxypyridin-3-yl]-2-methyl-2H-indazole-7-carbonitrile; 5-(7-fluoro-2-methyl-2H-indazol-5-yl)-2-(6-{[(3R,4S)-3-fluoro-2,2,6,6-tetramethylpiperidin-4-yl]oxy}pyridazin-3-yl)pyridin-3-ol; 5-(7-fluoro-2-methyl-2H-indazol-5-yl)-2-(6-{[(3S,4R)-3-fluoro-2,2,6,6-tetramethylpiperidin-4-yl]oxy}pyridazin-3-yl)pyridin-3-ol; 2-(6-{[(1R,3s,5S)-1,5-dimethyl-8-azabicyclo[3.2.1]octan-3-yl]oxy}pyridazin-3-yl)-5-(pyrimidin-5-yl)pyridin-3-ol; 2-(6-{[(1S,3r,5R)-1,5-dimethyl-8-azabicyclo[3.2.1]octan-3-yl]oxy}pyridazin-3-yl)-5-(pyrimidin-5-yl)pyridin-3-ol; 6-(6-{[(3R,4S)-3-fluoro-2,2,6,6-tetramethylpiperidin-4-yl]oxy}pyridazin-3-yl)-5-hydroxy-1'-methyl[3,4'-bipyridin]-2'(1'H)-one; 6-(6-{[(3S,4R)-3-fluoro-2,2,6,6-tetramethylpiperidin-4-yl]oxy}pyridazin-3-yl)-5-hydroxy-1'-methyl[3,4'-bipyridin]-2'(1'H)-one; 5-(2,8-dimethylimidazo[1,2-b]pyridazin-6-yl)-2-(6-{[(3R,4S)-3-fluoro-2,2,6,6-tetramethylpiperidin-4-yl]oxy}pyridazin-3-yl)pyridin-3-ol; 5-(2,8-dimethylimidazo[1,2-b]pyridazin-6-yl)-2-(6-{[(3S,4R)-3-fluoro-2,2,6,6-tetramethylpiperidin-4-yl]oxy}pyridazin-3-yl)pyridin-3-ol; 2-(6-{[(3S,4R)-3-fluoro-2,2,6,6-tetramethylpiperidin-4-yl]oxy}pyridazin-3-yl)-5-(1H-pyrazol-4-yl)pyridin-3-ol; 2-(6-{[(3R,4S)-3-fluoro-2,2,6,6-tetramethylpiperidin-4-yl]oxy}pyridazin-3-yl)-5-(1H-pyrazol-4-yl)pyridin-3-ol; 5-(5-fluoro-1H-pyrazol-4-yl)-2-(6-{[(3S,4R)-3-fluoro-2,2,6,6-tetramethylpiperidin-4-yl]oxy}pyridazin-3-yl)pyridin-3-ol; 2-(6-{[(3R,4S)-3-fluoro-2,2,6,6-tetramethylpiperidin-4-yl]oxy}pyridazin-3-yl)-5-(4-methyl-1H-imidazol-1-yl)pyridin-3-ol; 2-(6-{[(3S,4R)-3-fluoro-2,2,6,6-tetramethylpiperidin-4-yl]oxy}pyridazin-3-yl)-5-(4-methyl-1H-imidazol-1-yl)pyridin-3-ol; 6-[6-(6-{[(3R,4S)-3-fluoro-2,2,6,6-tetramethylpiperidin-4-yl]oxy}pyridazin-3-yl)-5-hydroxypyridin-3-yl]-3-methylpyrimidin-4(3H)-one; 6-[6-(6-{[(3S,4R)-3-fluoro-2,2,6,6-tetramethylpiperidin-4-yl]oxy}pyridazin-3-yl)-5-hydroxypyridin-3-yl]-3-methylpyrimidin-4(3H)-one; 2-(6-{[(3R,4S)-3-fluoro-2,2,6,6-tetramethylpiperidin-4-yl]oxy}pyridazin-3-yl)-5-(2-methylimidazo[1,2-a]pyridin-6-yl)pyridin-3-ol; 2-(6-{[(3S,4R)-3-fluoro-2,2,6,6-tetramethylpiperidin-4-yl]oxy}pyridazin-3-yl)-5-(2-methylimidazo[1,2-a]pyridin-6-yl)pyridin-3-ol; 5-(2,8-dimethylimidazo[1,2-a]pyridin-6-yl)-2-(6-{[(3R,4S)-3-fluoro-2,2,6,6-tetramethylpiperidin-4-yl]oxy}pyridazin-3-yl)pyridin-3-ol; 5-(2,8-dimethylimidazo[1,2-a]pyridin-6-yl)-2-(6-{[(3S,4R)-3-fluoro-2,2,6,6-tetramethylpiperidin-4-yl]oxy}pyridazin-3-yl)pyridin-3-ol; 5-(8-ethyl-2-methylimidazo[1,2-a]pyridin-6-yl)-2-(6-{[(3R,4S)-3-fluoro-2,2,6,6-tetramethylpiperidin-4-yl]oxy}pyridazin-3-yl)pyridin-3-ol; 5-(8-ethyl-2-methylimidazo[1,2-a]pyridin-6-yl)-2-(6-{[(3S,4R)-3-fluoro-2,2,6,6-tetramethylpiperidin-4-yl]oxy}pyridazin-3-yl)pyridin-3-ol; 2-(6-{[(3R,4S)-3-fluoro-2,2,6,6-tetramethylpiperidin-4-yl]oxy}pyridazin-3-yl)-5-[2-methyl-8-(trifluoromethyl)imidazo[1,2-a]pyridin-6-yl]pyridin-3-ol; 2-(6-{[(3S,4R)-3-fluoro-2,2,6,6-tetramethylpiperidin-4-yl]oxy}pyridazin-3-yl)-5-[2-methyl-8-(trifluoromethyl)imidazo[1,2-a]pyridin-6-yl]pyridin-3-ol; 5-(2,8-dimethylimidazo[1,2-b]pyridazin-6-yl)-2-(6-{[(3R,4S)-3-fluoro-2,2,6,6-tetramethylpiperidin-4-yl]oxy}pyridazin-3-yl)pyridin-3-ol; 5-(2,8-dimethylimidazo[1,2-b]pyridazin-6-yl)-2-(6-{[(3S,4R)-3-fluoro-2,2,6,6-tetramethylpiperidin-4-yl]oxy}pyridazin-3-yl)pyridin-3-ol; 2-(6-{[(3R,4S)-3-fluoro-2,2,6,6-tetramethylpiperidin-4-yl]oxy}pyridazin-3-yl)-5-(2-methylimidazo[1,2-b]pyridazin-6-yl)pyridin-3-ol; 2-(6-{[(3S,4R)-3-fluoro-2,2,6,6-tetramethylpiperidin-4-yl]oxy}pyridazin-3-yl)-5-(2-methylimidazo[1,2-b]pyridazin-6-yl)pyridin-3-ol; 2-(6-{[(3R,4S)-3-fluoro-2,2,6,6-tetramethylpiperidin-4-yl]oxy}pyridazin-3-yl)-5-(imidazo[1,2-b]pyridazin-6-yl)pyridin-3-ol; 2-(6-{[(3S,4R)-3-fluoro-2,2,6,6-tetramethylpiperidin-4-yl]oxy}pyridazin-3-yl)-5-(imidazo[1,2-b]pyridazin-6-yl)pyridin-3-ol; 5-(2,8-dimethylimidazo[1,2-b]pyridazin-6-yl)-2-{6-[(2,2,6,6-tetramethylpiperidin-4-yl)oxy]pyridazin-3-yl}pyridin-3-ol; 2-(6-{[(3R,4S)-3-fluoro-2,2,6,6-tetramethylpiperidin-4-yl]oxy}pyridazin-3-yl)-5-(1H-pyrazol-4-yl)pyridin-3-ol; 2-(6-{[(3S,4R)-3-fluoro-2,2,6,6-tetramethylpiperidin-4-yl]oxy}pyridazin-3-yl)-5-(1H-pyrazol-4-yl)pyridin-3-ol; 5-(7-fluoro-2-methyl-2H-indazol-5-yl)-2-{6-[(2,2,6,6-tetramethylpiperidin-4-yl)oxy]pyridazin-3-yl}pyridin-3-ol; 2-{6-[(5,5-dimethyl-4-azaspiro[2.5]octan-7-yl)(methyl)amino]pyridazin-3-yl}-5-[1-( 2 H 3 ) methyl-1H-pyrazol-4-yl]pyridin-3-ol; 2-(6-{[(3R,4S)-3-fluoro-2,2,6,6-tetramethylpiperidin-4-yl]oxy}pyridazin-3-yl)-5-(2-methylimidazo[1,2-a]pyrimidin-6-yl)pyridin-3-ol; 2-(6-{[(3S,4R)-3-fluoro-2,2,6,6-tetramethylpiperidin-4-yl]oxy}pyridazin-3-yl)-5-(2-methylimidazo[1,2-a]pyrimidin-6-yl)pyridin-3-ol; 2-(6-{[(3R,4S)-3-fluoro-2,2,6,6-tetramethylpiperidin-4-yl]oxy}pyridazin-3-yl)-5-(2-methyl[1,2,4]triazolo[1,5-a]pyridin-6-yl)pyridin-3-ol; 2-(6-{[(3S,4R)-3-fluoro-2,2,6,6-tetramethylpiperidin-4-yl]oxy}pyridazin-3-yl)-5-(2-methyl[1,2,4]triazolo[1,5-a]pyridin-6-yl)pyridin-3-ol; 5-(2,4-dimethyl-1,3-benzoxazol-6-yl)-2-(6-{[(3R,4S)-3-fluoro-2,2,6,6-tetramethylpiperidin-4-yl]oxy}pyridazin-3-yl)pyridin-3-ol; 5-(2,4-dimethyl-1,3-benzoxazol-6-yl)-2-(6-{[(3S,4R)-3-fluoro-2,2,6,6-tetramethylpiperidin-4-yl]oxy}pyridazin-3-yl)pyridin-3-ol; 2-(6-{[(3R,4S)-3-fluoro-2,2,6,6-tetramethylpiperidin-4-yl]oxy}pyridazin-3-yl)-5-(8-methoxy-2-methylimidazo[1,2-b]pyridazin-6-yl)pyridin-3-ol; 2-(6-{[(3S,4R)-3-fluoro-2,2,6,6-tetramethylpiperidin-4-yl]oxy}pyridazin-3-yl)-5-(8-methoxy-2-methylimidazo[1,2-b]pyridazin-6-yl)pyridin-3-ol; 5-(7-fluoro-2-methyl-2H-indazol-4-yl)-2-(6-{[(3R,4S)-3-fluoro-2,2,6,6-tetramethylpiperidin-4-yl]oxy}pyridazin-3-yl)pyridin-3-ol; 5-(7-fluoro-2-methyl-2H-indazol-4-yl)-2-(6-{[(3S,4R)-3-fluoro-2,2,6,6-tetramethylpiperidin-4-yl]oxy}pyridazin-3-yl)pyridin-3-ol; 6-[6-(6-{[(3R,4S)-3-fluoro-2,2,6,6-tetramethylpiperidin-4-yl]oxy}pyridazin-3-yl)-5-hydroxypyridin-3-yl]-2-methylimidazo[1,2-a]pyridine-8-carbonitrile; 6-[6-(6-{[(3S,4R)-3-fluoro-2,2,6,6-tetramethylpiperidin-4-yl]oxy}pyridazin-3-yl)-5-hydroxypyridin-3-yl]-2-methylimidazo[1,2-a]pyridine-8-carbonitrile; 5-(8-ethyl-2-methylimidazo[1,2-b]pyridazin-6-yl)-2-(6-{[(3R,4S)-3-fluoro-2,2,6,6-tetramethylpiperidin-4-yl]oxy}pyridazin-3-yl)pyridin-3-ol; 5-(8-ethyl-2-methylimidazo[1,2-b]pyridazin-6-yl)-2-(6-{[(3S,4R)-3-fluoro-2,2,6,6-tetramethylpiperidin-4-yl]oxy}pyridazin-3-yl)pyridin-3-ol; 2-{6-[(2,2,6,6-tetramethylpiperidin-4-yl)oxy]pyridazin-3-yl}-5-(1H-1,2,4-triazol-1-yl)pyridin-3-ol; 5-[6-(6-{[2,2,6,6-tetramethylpiperidin-4-yl]oxy}pyridazin-3-yl)-5-hydroxypyridin-3-yl]-2-methyl-2H-indazole-7-carbonitrile; 2-{6-[(2,2,6,6-tetramethylpiperidin-4-yl)oxy]pyridazin-3-yl}-5-(1H-1,2,3-triazol-1-yl)pyridin-3-ol; 2-{6-[(5,5-dimethyl-4-azaspiro[2.5]octan-7-yl)(methyl)amino]pyridazin-3-yl}-5-(7-fluoro-2-methyl-2H-indazol-5-yl)pyridin-3-ol; 5-(imidazo[1,2-b]pyridazin-6-yl)-2-{6-[(2,2,6,6-tetramethylpiperidin-4-yl)oxy]pyridazin-3-yl}pyridin-3-ol; 2-(6-{[(3R,4S)-3-fluoro-2,2,6,6-tetramethylpiperidin-4-yl]oxy}pyridazin-3-yl)-5-(imidazo[1,2-a]pyrazin-6-yl)pyridin-3-ol; 2-(6-{[(3S,4R)-3-fluoro-2,2,6,6-tetramethylpiperidin-4-yl]oxy}pyridazin-3-yl)-5-(imidazo[1,2-a]pyrazin-6-yl)pyridin-3-ol; 5-(1,3-dimethylpyrrolo[1,2-a]pyrazin-7-yl)-2-(6-{[(3R,4S)-3-fluoro-2,2,6,6-tetramethylpiperidin-4-yl]oxy}pyridazin-3-yl)pyridin-3-ol; 5-(1,3-dimethylpyrrolo[1,2-a]pyrazin-7-yl)-2-(6-{[(3S,4R)-3-fluoro-2,2,6,6-tetramethylpiperidin-4-yl]oxy}pyridazin-3-yl)pyridin-3-ol; 6-[6-(6-{[(3R,4S)-3-fluoro-2,2,6,6-tetramethylpiperidin-4-yl]oxy}pyridazin-3-yl)-5-hydroxypyridin-3-yl]-2-methylimidazo[1,2-b]pyridazine-8-carbonitrile; 6-[6-(6-{[(3S,4R)-3-fluoro-2,2,6,6-tetramethylpiperidin-4-yl]oxy}pyridazin-3-yl)-5-hydroxypyridin-3-yl]-2-methylimidazo[1,2-b]pyridazine-8-carbonitrile; 2-{6-[(3R,5S)-3,5-dimethylpiperazin-1-yl]pyridazin-3-yl}-5-(7-fluoro-2-methyl-2H-indazol-5-yl)pyridin-3-ol; 2-{6-[(3S,5R)-3,5-dimethylpiperazin-1-yl]pyridazin-3-yl}-5-(7-fluoro-2-methyl-2H-indazol-5-yl)pyridin-3-ol; 5-(6-methoxypyrimidin-4-yl)-2-{6-[(3R)-3-(methylamino)pyrrolidin-1-yl]pyridazin-3-yl}pyridin-3-ol; 2-(6-{[(1R,3s,5S)-1,5-dimethyl-8-azabicyclo[3.2.1]octan-3-yl]oxy}pyridazin-3-yl)-5-(1H-1,2,3-triazol-1-yl)pyridin-3-ol; 2-(6-{[(1S,3r,5S)-1,5-dimethyl-8-azabicyclo[3.2.1]octan-3-yl]oxy}pyridazin-3-yl)-5-(1H-1,2,3-triazol-1-yl)pyridin-3-ol; 2-(6-{[(3R,4S)-3-fluoro-2,2,6,6-tetramethylpiperidin-4-yl]oxy}pyridazin-3-yl)-5-([1,2,4]triazolo[1,5-a]pyrazin-2-yl)pyridin-3-ol; 2-(6-{[(3S,4R)-3-fluoro-2,2,6,6-tetramethylpiperidin-4-yl]oxy}pyridazin-3-yl)-5-([1,2,4]triazolo[1,5-a]pyrazin-2-yl)pyridin-3-ol; 2-{6-[(4-azadispiro[2.1.2 5 .3 3 ]decan-9-yl)oxy]pyridazin-3-yl}-5-(2H-1,2,3-triazol-2-yl)pyridin-3-ol; 5-(6-methoxypyrimidin-4-yl)-2-{6-[(2,2,6,6-tetramethylpiperidin-4-yl)oxy]pyridazin-3-yl}pyridin-3-ol; 2-{6-[(5,5-dimethyl-4-azaspiro[2.5]octan-7-yl)oxy]pyridazin-3-yl}-5-[1-( 2 H 3 ) methyl-1H-pyrazol-4-yl]pyridin-3-ol; 2-{6-[(3R)-3-(tert-butylamino)pyrrolidin-1-yl]pyridazin-3-yl}-5-(2-methyl-1,3-oxazol-5-yl)pyridin-3-ol; 2-{6-[(3R)-3-(methylamino)pyrrolidin-1-yl]pyridazin-3-yl}-5-(2-methyl-1,3-oxazol-5-yl)pyridin-3-ol; 5-(6-{6-[(3R,5S)-3,5-dimethylpiperazin-1-yl]pyridazin-3-yl}-5-hydroxypyridin-3-yl)-2-methyl-2H-indazole-7-carbonitrile; 5-(6-{6-[(3S,5R)-3,5-dimethylpiperazin-1-yl]pyridazin-3-yl}-5-hydroxypyridin-3-yl)-2-methyl-2H-indazole-7-carbonitrile; 2-{6-[(5,5-dimethyl-4-azaspiro[2.5]octan-7-yl)oxy]pyridazin-3-yl}-5-(1,3-thiazol-2-yl)pyridin-3-ol; 2-{6-[(3R)-3-(methylamino)pyrrolidin-1-yl]pyridazin-3-yl}-5-(1,3-oxazol-2-yl)pyridin-3-ol; 5-(8-methoxy-2-methylimidazo[1,2-b]pyridazin-6-yl)-2-{6-[(2,2,6,6-tetramethylpiperidin-4-yl)oxy]pyridazin-3-yl}pyridin-3-ol; 2-(6-{[(5R,7S)-5-methyl-4-azaspiro[2.5]octan-7-yl]oxy}pyridazin-3-yl)-5-[1-( 2 H 3 ) methyl-1H-pyrazol-4-yl]pyridin-3-ol; 2-(6-{[(5S,7R)-5-methyl-4-azaspiro[2.5]octan-7-yl]oxy}pyridazin-3-yl)-5-[1-( 2 H 3 ) methyl-1H-pyrazol-4-yl]pyridin-3-ol; 2-(6-{[(5S,7S)-5-methyl-4-azaspiro[2.5]octan-7-yl]oxy}pyridazin-3-yl)-5-[1-( 2 H 3 ) methyl-1H-pyrazol-4-yl]pyridin-3-ol; 2-(6-{[(5R,7R)-5-methyl-4-azaspiro[2.5]octan-7-yl]oxy}pyridazin-3-yl)-5-[1-( 2 H 3 ) methyl-1H-pyrazol-4-yl]pyridin-3-ol; 2-{6-[(3R,5S)-3,5-dimethylpiperazin-1-yl]pyridazin-3-yl}-5-(1H-pyrazol-4-yl)pyridin-3-ol; 2-{6-[(3S,5R)-3,5-dimethylpiperazin-1-yl]pyridazin-3-yl}-5-(1H-pyrazol-4-yl)pyridin-3-ol; 2-{6-[(3R,5S)-3,5-dimethylpiperazin-1-yl]pyridazin-3-yl}-5-(7-methoxy-2-methyl-2H-indazol-5-yl)pyridin-3-ol; 2-{6-[(3S,5R)-3,5-dimethylpiperazin-1-yl]pyridazin-3-yl}-5-(7-methoxy-2-methyl-2H-indazol-5-yl)pyridin-3-ol; 5-(1H-pyrazol-4-yl)-2-[6-(3,3,5,5-tetramethylpiperazin-1-yl)pyridazin-3-yl]pyridin-3-ol; 5-(7-fluoro-2-methyl-2H-indazol-5-yl)-2-[6-(3,3,5,5-tetramethylpiperazin-1-yl)pyridazin-3-yl]pyridin-3-ol; 5-(1H-pyrazol-4-yl)-2-{6-[(3R,5S)-3,4,5-trimethylpiperazin-1-yl]pyridazin-3-yl}pyridin-3-ol; 5-(1H-pyrazol-4-yl)-2-{6-[(3S,5R)-3,4,5-trimethylpiperazin-1-yl]pyridazin-3-yl}pyridin-3-ol; 5-(7-fluoro-2-methyl-2H-indazol-5-yl)-2-{6-[(3R,5S)-3,4,5-trimethylpiperazin-1-yl]pyridazin-3-yl}pyridin-3-ol; 5-(7-fluoro-2-methyl-2H-indazol-5-yl)-2-{6-[(3S,5R)-3,4,5-trimethylpiperazin-1-yl]pyridazin-3-yl}pyridin-3-ol; 2-{6-[(3R,5S)-3,5-dimethylpiperazin-1-yl]pyridazin-3-yl}-5-(2-methylimidazo[1,2-a]pyridin-6-yl)pyridin-3-ol; 2-{6-[(3S,5R)-3,5-dimethylpiperazin-1-yl]pyridazin-3-yl}-5-(2-methylimidazo[1,2-a]pyridin-6-yl)pyridin-3-ol; 5-(7-fluoro-2-methyl-2H-indazol-5-yl)-2-[6-(piperazin-1-yl)pyridazin-3-yl]pyridin-3-ol; 2-{6-[(3R,5S)-3,5-dimethylpiperazin-1-yl]pyridazin-3-yl}-5-([1,2,4]triazolo[1,5-a]pyridin-6-yl)pyridin-3-ol; 2-{6-[(3S,5R)-3,5-dimethylpiperazin-1-yl]pyridazin-3-yl}-5-([1,2,4]triazolo[1,5-a]pyridin-6-yl)pyridin-3-ol; 5-(7-methoxy-2-methyl-2H-indazol-5-yl)-2-[6-(3-methylpiperazin-1-yl)pyridazin-3-yl]pyridin-3-ol; 6-{6-[(3R,5S)-3,5-dimethylpiperazin-1-yl]pyridazin-3-yl}-2'-methoxy[3,4'-bipyridin]-5-ol; 6-{6-[(3S,5R)-3,5-dimethylpiperazin-1-yl]pyridazin-3-yl}-2'-methoxy[3,4'-bipyridin]-5-ol; 5-(7-fluoro-2-methyl-2H-indazol-5-yl)-2-[6-(3-methylpiperazin-1-yl)pyridazin-3-yl]pyridin-3-ol; 2-[6-(4,7-diazaspiro[2.5]octan-7-yl)pyridazin-3-yl]-5-(7-fluoro-2-methyl-2H-indazol-5-yl)pyridin-3-ol; 2-{6-[(3R,5S)-3,5-dimethylpiperazin-1-yl]pyridazin-3-yl}-5-(2-methyl[1,2,4]triazolo[1,5-a]pyridin-6-yl)pyridin-3-ol; 2-{6-[(3S,5R)-3,5-dimethylpiperazin-1-yl]pyridazin-3-yl}-5-(2-methyl[1,2,4]triazolo[1,5-a]pyridin-6-yl)pyridin-3-ol; 2-[6-(4-cyclopropylpiperazin-1-yl)pyridazin-3-yl]-5-(7-fluoro-2-methyl-2H-indazol-5-yl)pyridin-3-ol; 5-(7-fluoro-2-methyl-2H-indazol-5-yl)-2-[6-(4-methylpiperazin-1-yl)pyridazin-3-yl]pyridin-3-ol; [(3R,4S)-3-fluoro-4-({6-[3-hydroxy-5-(1H-pyrazol-4-yl)pyridin-2-yl]pyridazin-3-yl}oxy)-2,2,6,6-tetramethylpiperidin-1-yl]oxidanyl; 5-(7-fluoro-2-methyl-2H-indazol-5-yl)-2-{6-[(3S)-3-methylpiperazin-1-yl]pyridazin-3-yl}pyridin-3-ol; 5-(7-fluoro-2-methyl-2H-indazol-5-yl)-2-{6-[(3R)-3-methylpiperazin-1-yl]pyridazin-3-yl}pyridin-3-ol; 2-[6-(2,5-diazabicyclo[2.2.1]heptan-2-yl)pyridazin-3-yl]-5-(7-fluoro-2-methyl-2H-indazol-5-yl)pyridin-3-ol; 2-{6-[(3R,5R)-3,5-dimethylpiperazin-1-yl]pyridazin-3-yl}-5-(7-fluoro-2-methyl-2H-indazol-5-yl)pyridin-3-ol; 2-{6-[(3S,5R)-3,5-dimethylpiperazin-1-yl]pyridazin-3-yl}-5-(7-fluoro-2-methyl-2H-indazol-5-yl)pyridin-3-ol; 2-[6-(1,6-diazaspiro[3.4]octan-6-yl)pyridazin-3-yl]-5-(2-methylimidazo[1,2-a]pyridin-6-yl)pyridin-3-ol; 2-[6-(3-methylpiperazin-1-yl)pyridazin-3-yl]-5-{[(3-methyl-1H-pyrazol-4-yl)methyl]amino}pyridin-3-ol; 2-[6-(3-methylpiperazin-1-yl)pyridazin-3-yl]-5-{[(pyridin-2-yl)methyl]amino}pyridin-3-ol; 2-[6-(3-methylpiperazin-1-yl)pyridazin-3-yl]-5-{[(pyridin-3-yl)methyl]amino}pyridin-3-ol; 2-[6-(3-methylpiperazin-1-yl)pyridazin-3-yl]-5-{[(pyridin-4-yl)methyl]amino}pyridin-3-ol; 2-[6-(3-methylpiperazin-1-yl)pyridazin-3-yl]-5-{[(quinolin-3-yl)methyl]amino}pyridin-3-ol; 2-[6-(3-methylpiperazin-1-yl)pyridazin-3-yl]-5-{[(quinolin-8-yl)methyl]amino}pyridin-3-ol; 2-{6-[(6,6-dimethyl-2-oxa-5-azaspiro[3.5]nonan-8-yl)oxy]pyridazin-3-yl}-5-(1H-pyrazol-4-yl)pyridin-3-ol; 2-{6-[(3R,5S)-3,5-dimethylpiperazin-1-yl]pyridazin-3-yl}-5-(2-methylimidazo[1,2-a]pyrimidin-6-yl)pyridin-3-ol; 2-{6-[(3S,5R)-3,5-dimethylpiperazin-1-yl]pyridazin-3-yl}-5-(2-methylimidazo[1,2-a]pyrimidin-6-yl)pyridin-3-ol; 2-[6-(2,5-diazabicyclo[2.2.1]heptan-2-yl)pyridazin-3-yl]-5-(2-methylimidazo[1,2-a]pyrimidin-6-yl)pyridin-3-ol; 2-[6-(3-methylpiperazin-1-yl)pyridazin-3-yl]-5-[(pyridin-3-yl)amino]pyridin-3-ol; 2-{6-[(3R,5S)-3,5-dimethylpiperazin-1-yl]pyridazin-3-yl}-5-[(E)-2-(1-methyl-1H-pyrazol-4-yl)ethenyl]pyridin-3-ol; 2-{6-[(3S,5R)-3,5-dimethylpiperazin-1-yl]pyridazin-3-yl}-5-[(E)-2-(1-methyl-1H-pyrazol-4-yl)ethenyl]pyridin-3-ol; 2-[6-(3-ethylpiperazin-1-yl)pyridazin-3-yl]-5-(1H-pyrazol-4-yl)pyridin-3-ol; 2-[6-(3-ethylpiperazin-1-yl)pyridazin-3-yl]-5-(7-fluoro-2-methyl-2H-indazol-5-yl)pyridin-3-ol; 2-{6-[(3S)-3-(propan-2-yl)piperazin-1-yl]pyridazin-3-yl}-5-(1H-pyrazol-4-yl)pyridin-3-ol; 2-{6-[(3R)-3-(propan-2-yl)piperazin-1-yl]pyridazin-3-yl}-5-(1H-pyrazol-4-yl)pyridin-3-ol; 5-(7-fluoro-2-methyl-2H-indazol-5-yl)-2-{6-[(3S)-3-(propan-2-yl)piperazin-1-yl]pyridazin-3-yl}pyridin-3-ol; 2-[6-(3-cyclopropylpiperazin-1-yl)pyridazin-3-yl]-5-(1H-pyrazol-4-yl)pyridin-3-ol; 2-{6-[(3R,5S)-3,5-dimethylpiperazin-1-yl]pyridazin-3-yl}-5-(2-methyl-2H-indazol-5-yl)pyridin-3-ol; 2-{6-[(3S,5R)-3,5-dimethylpiperazin-1-yl]pyridazin-3-yl}-5-(2-methyl-2H-indazol-5-yl)pyridin-3-ol; 2-{6-[(3R,5S)-3,5-dimethylpiperazin-1-yl]pyridazin-3-yl}-5-[(6-methylpyridin-3-yl)amino]pyridin-3-ol; 2-{6-[(3R,5S)-3,5-dimethylpiperazin-1-yl]pyridazin-3-yl}-5-(1-methyl-1H-indazol-5-yl)pyridin-3-ol; 2-{6-[(3S,5R)-3,5-dimethylpiperazin-1-yl]pyridazin-3-yl}-5-(1-methyl-1H-indazol-5-yl)pyridin-3-ol; 5-[(6-methylpyridin-3-yl)amino]-2-{6-[(3R)-3-(propan-2-yl)piperazin-1-yl]pyridazin-3-yl}pyridin-3-ol; 5-[(6-methylpyridin-3-yl)amino]-2-{6-[(3S)-3-(propan-2-yl)piperazin-1-yl]pyridazin-3-yl}pyridin-3-ol; 2-{6-[(3S)-3-cyclopropylpiperazin-1-yl]pyridazin-3-yl}-5-(2H-1,2,3-triazol-2-yl)pyridin-3-ol; 2-{6-[(3S)-3-cyclopropylpiperazin-1-yl]pyridazin-3-yl}-5-[1-( 2 H 3 ) methyl-1H-pyrazol-4-yl]pyridin-3-ol; 2-{6-[3-(propan-2-yl)piperazin-1-yl]pyridazin-3-yl}-5-[(E)-2-(1H-pyrazol-4-yl)ethenyl]pyridin-3-ol; 2-{6-[(3R,5S)-3,5-dimethylpiperazin-1-yl]pyridazin-3-yl}-5-(2H-indazol-5-yl)pyridin-3-ol; 2-{6-[(3S,5R)-3,5-dimethylpiperazin-1-yl]pyridazin-3-yl}-5-(2H-indazol-5-yl)pyridin-3-ol; 2-{6-[(3S)-3-ethylpiperazin-1-yl]pyridazin-3-yl}-5-(1H-pyrazol-4-yl)pyridin-3-ol; 5-[(5-methylpyrazin-2-yl)amino]-2-{6-[(3R)-3-(propan-2-yl)piperazin-1-yl]pyridazin-3-yl}pyridin-3-ol; 5-[(5-methylpyrazin-2-yl)amino]-2-{6-[(3S)-3-(propan-2-yl)piperazin-1-yl]pyridazin-3-yl}pyridin-3-ol; 5-[(2-methylpyrimidin-5-yl)amino]-2-{6-[(3R)-3-(propan-2-yl)piperazin-1-yl]pyridazin-3-yl}pyridin-3-ol; 5-[(2-methylpyrimidin-5-yl)amino]-2-{6-[(3S)-3-(propan-2-yl)piperazin-1-yl]pyridazin-3-yl}pyridin-3-ol; 2-{3-[methyl(2,2,6,6-tetramethylpiperidin-4-yl)amino]-1,2,4-triazin-6-yl}-5-(1H-pyrazol-4-yl)pyridin-3-ol; 2-{3-[3-(tert-butylamino)pyrrolidin-1-yl]-1,2,4-triazin-6-yl}-5-(1H-pyrazol-4-yl)pyridin-3-ol; 2-{3-[3-(tert-butylamino)pyrrolidin-1-yl]-1,2,4-triazin-6-yl}-5-[1-( 2 H 3 ) methyl-1H-pyrazol-4-yl]pyridin-3-ol; 2-{3-[3-(tert-butylamino)pyrrolidin-1-yl]-1,2,4-triazin-6-yl}-5-(2H-1,2,3-triazol-2-yl)pyridin-3-ol; 2-(3-{[(3S,4S)-3-fluoro-2,2,6,6-tetramethylpiperidin-4-yl]amino}-1,2,4-triazin-6-yl)-5-(1H-pyrazol-4-yl)pyridin-3-ol; 2-(3-{[(3R,4R)-3-fluoro-2,2,6,6-tetramethylpiperidin-4-yl]amino}-1,2,4-triazin-6-yl)-5-(1H-pyrazol-4-yl)pyridin-3-ol; 2-(3-{[(3R,4R)-3-fluoro-2,2,6,6-tetramethylpiperidin-4-yl]amino}-1,2,4-triazin-6-yl)-5-[1-( 2 H 3 ) methyl-1H-pyrazol-4-yl]pyridin-3-ol; 2-(3-{[(3S,4S)-3-fluoro-2,2,6,6-tetramethylpiperidin-4-yl]amino}-1,2,4-triazin-6-yl)-5-[1-( 2 H 3 ) methyl-1H-pyrazol-4-yl]pyridin-3-ol; 5-(1H-pyrazol-4-yl)-2-{3-[(2,2,6,6-tetramethylpiperidin-4-yl)oxy]-1,2,4-triazin-6-yl}pyridin-3-ol; 5-[1-( 2 H 3 ) methyl-1H-pyrazol-4-yl]-2-{3-[methyl(2,2,6,6-tetramethylpiperidin-4-yl)amino]-1,2,4-triazin-6-yl}pyridin-3-ol; 5-(5-fluoro-1H-pyrazol-4-yl)-2-{3-[methyl(2,2,6,6-tetramethylpiperidin-4-yl)amino]-1,2,4-triazin-6-yl}pyridin-3-ol; 2-{3-[methyl(2,2,6,6-tetramethylpiperidin-4-yl)amino]-1,2,4-triazin-6-yl}-5-(2H-1,2,3-triazol-2-yl)pyridin-3-ol; 2-{3-[(3S)-3-(tert-butylamino)pyrrolidin-1-yl]-1,2,4-triazin-6-yl}-5-(3-fluoro-1H-pyrazol-4-yl)pyridin-3-ol; 2-{3-[(3R)-3-(tert-butylamino)pyrrolidin-1-yl]-1,2,4-triazin-6-yl}-5-(7-methoxy-2-methyl-2H-indazol-5-yl)pyridin-3-ol; 6-(6-{3-[(3R)-3-(tert-butylamino)pyrrolidin-1-yl]-1,2,4-triazin-6-yl}-5-hydroxypyridin-3-yl)-2-methylimidazo[1,2-a]pyridine-8-carbonitrile; 2-{3-[(3R)-3-(tert-butylamino)pyrrolidin-1-yl]-1,2,4-triazin-6-yl}-5-(8-ethyl-2-methylimidazo[1,2-a]pyridin-6-yl)pyridin-3-ol; 2-{3-[(3R)-3-(tert-butylamino)pyrrolidin-1-yl]-1,2,4-triazin-6-yl}-5-(2,8-dimethylimidazo[1,2-b]pyridazin-6-yl)pyridin-3-ol; 5-(7-methoxy-2-methyl-2H-indazol-5-yl)-2-[3-(4-methylpiperazin-1-yl)-1,2,4-triazin-6-yl]pyridin-3-ol; 5-(8-fluoro-2-methylimidazo[1,2-a]pyridin-6-yl)-2-[3-(4-methylpiperazin-1-yl)-1,2,4-triazin-6-yl]pyridin-3-ol; 2-[3-(4-methylpiperazin-1-yl)-1,2,4-triazin-6-yl]-5-(1H-pyrazol-4-yl)pyridin-3-ol; 5-(2,8-dimethylimidazo[1,2-a]pyridin-6-yl)-2-[3-(4-methylpiperazin-1-yl)-1,2,4-triazin-6-yl]pyridin-3-ol; 5-[(5-methylpyrazin-2-yl)amino]-2-{3-[(3S)-3-(propan-2-yl)piperazin-1-yl]-1,2,4-triazin-6-yl}pyridin-3-ol; 5-(7-fluoro-2-methyl-2H-indazol-5-yl)-2-{3-[(3S)-3-(propan-2-yl)piperazin-1-yl]-1,2,4-triazin-6-yl}pyridin-3-ol; 2-{3-[(3S)-3-(propan-2-yl)piperazin-1-yl]-1,2,4-triazin-6-yl}-5-(2H-1,2,3-triazol-2-yl)pyridin-3-ol; 2-{3-[(3S)-3-cyclopropylpiperazin-1-yl]-1,2,4-triazin-6-yl}-5-(2-methyl-2H-[1,2,3]triazolo[4,5-b]pyridin-6-yl)pyridin-3-ol; 2-{3-[(3S)-3-cyclopropylpiperazin-1-yl]-1,2,4-triazin-6-yl}-5-(7-fluoro-2-methyl-2H-indazol-5-yl)pyridin-3-ol; 2-{3-[(3S)-3-cyclopropylpiperazin-1-yl]-1,2,4-triazin-6-yl}-5-(2H-1,2,3-triazol-2-yl)pyridin-3-ol; 2-{3-[(3S)-3-cyclopropylpiperazin-1-yl]-1,2,4-triazin-6-yl}-5-[(5-methylpyrazin-2-yl)amino]pyridin-3-ol; 2-{6-[methyl(2,2,6,6-tetramethylpiperidin-4-yl)amino]-1,2,4-triazin-3-yl}-5-(2H-1,2,3-triazol-2-yl)pyridin-3-ol; 2-{6-[methyl(2,2,6,6-tetramethylpiperidin-4-yl)amino]-1,2,4-triazin-3-yl}-5-(1H-pyrazol-4-yl)pyridin-3-ol; 2-{6-[(2,2,6,6-tetramethylpiperidin-4-yl)amino]-1,2,4-triazin-3-yl}-5-(2H-1,2,3-triazol-2-yl)pyridin-3-ol; 2-{6-[(3R,5S)-3,5-dimethylpiperazin-1-yl]-1,2,4-triazin-3-yl}-5-(7-fluoro-2-methyl-2H-indazol-5-yl)pyridin-3-ol; and 2-{6-[(3S,5R)-3,5-dimethylpiperazin-1-yl]-1,2,4-triazin-3-yl}-5-(7-fluoro-2-methyl-2H-indazol-5-yl)pyridin-3-ol or a form thereof selected from the group consisting of: wherein the form of the compound is selected from the group consisting of a salt, a hydrate, a solvate, a racemate, an enantiomer, a diastereoisomer, and a tautomer thereof.

10. 5-(1H-pyrazol-4-yl)-2-{6-[(2,2,6,6-tetramethylpiperidin-4-yl)oxy]pyridazin-3-yl}pyridin-3-ol; 2-{6-[methyl(2,2,6,6-tetramethylpiperidin-4-yl)amino]pyridazin-3-yl}-5-(1H-pyrazol-4-yl)pyridin-3-ol; 5-[1-( 2 H 3 ) methyl-1H-pyrazol-4-yl]-2-{6-[(2,2,6,6-tetramethylpiperidin-4-yl)oxy]pyridazin-3-yl}pyridin-3-ol; 5-(1-methyl-1H-pyrazol-3-yl)-2-{6-[(2,2,6,6-tetramethylpiperidin-4-yl)oxy]pyridazin-3-yl}pyridin-3-ol; 5-(1H-imidazol-1-yl)-2-{6-[(2,2,6,6-tetramethylpiperidin-4-yl)oxy]pyridazin-3-yl}pyridin-3-ol; 2-(6-{[(3R,4S)-3-fluoro-2,2,6,6-tetramethylpiperidin-4-yl]oxy}pyridazin-3-yl)-5-(1H-pyrazol-4-yl)pyridin-3-ol; 2-(6-{[(3S,4R)-3-fluoro-2,2,6,6-tetramethylpiperidin-4-yl]oxy}pyridazin-3-yl)-5-(1H-pyrazol-4-yl)pyridin-3-ol; 2-(6-{[(3R,4S)-3-fluoro-2,2,6,6-tetramethylpiperidin-4-yl]oxy}pyridazin-3-yl)-5-(1-methyl-1H-pyrazol-3-yl)pyridin-3-ol; 2-(6-{[(3S,4R)-3-fluoro-2,2,6,6-tetramethylpiperidin-4-yl]oxy}pyridazin-3-yl)-5-(1-methyl-1H-pyrazol-3-yl)pyridin-3-ol; 2-(6-{[(3R,4S)-3-fluoro-2,2,6,6-tetramethylpiperidin-4-yl]amino}pyridazin-3-yl)-5-(1H-pyrazol-4-yl)pyridin-3-ol; 2-(6-{[(3R,4S)-3-fluoro-2,2,6,6-tetramethylpiperidin-4-yl]oxy}pyridazin-3-yl)-5-(1H-imidazol-1-yl)pyridin-3-ol; 2-(6-{[(3S,4R)-3-fluoro-2,2,6,6-tetramethylpiperidin-4-yl]oxy}pyridazin-3-yl)-5-(1H-imidazol-1-yl)pyridin-3-ol; 5-(1,3-oxazol-2-yl)-2-{6-[(2,2,6,6-tetramethylpiperidin-4-yl)oxy]pyridazin-3-yl}pyridin-3-ol; 2-(6-{[(3R,4S)-3-fluoro-2,2,6,6-tetramethylpiperidin-4-yl]oxy}pyridazin-3-yl)-5-(2H-1,2,3-triazol-2-yl)pyridin-3-ol; 2-(6-{[(3S,4R)-3-fluoro-2,2,6,6-tetramethylpiperidin-4-yl]oxy}pyridazin-3-yl)-5-(2H-1,2,3-triazol-2-yl)pyridin-3-ol; 2-(6-{[(3R,4S)-3-fluoro-2,2,6,6-tetramethylpiperidin-4-yl]oxy}pyridazin-3-yl)-5-(1,3-oxazol-2-yl)pyridin-3-ol; 2-(6-{[(3S,4R)-3-fluoro-2,2,6,6-tetramethylpiperidin-4-yl]oxy}pyridazin-3-yl)-5-(1,3-oxazol-2-yl)pyridin-3-ol; 5-(1-methyl-1H-pyrazol-3-yl)-2-{6-[methyl(2,2,6,6-tetramethylpiperidin-4-yl)amino]pyridazin-3-yl}pyridin-3-ol; 2-{6-[methyl(2,2,6,6-tetramethylpiperidin-4-yl)amino]pyridazin-3-yl}-5-(1,3-oxazol-2-yl)pyridin-3-ol; 5-(1H-imidazol-1-yl)-2-{6-[methyl(2,2,6,6-tetramethylpiperidin-4-yl)amino]pyridazin-3-yl}pyridin-3-ol; 2-(6-{[(3S,4S)-3-fluoro-2,2,6,6-tetramethylpiperidin-4-yl]amino}pyridazin-3-yl)-5-(1H-pyrazol-3-yl)pyridin-3-ol; 2-(6-{[(3R,4R)-3-fluoro-2,2,6,6-tetramethylpiperidin-4-yl]amino}pyridazin-3-yl)-5-(1H-pyrazol-3-yl)pyridin-3-ol; 2-{6-[(3R)-(tert-butylamino)pyrrolidin-1-yl]pyridazin-3-yl}-5-(1-methyl-1H-pyrazol-3-yl)pyridin-3-ol; 2-{6-[(3S)-(tert-butylamino)pyrrolidin-1-yl]pyridazin-3-yl}-5-(1-methyl-1H-pyrazol-3-yl)pyridin-3-ol; 2-{6-[(3R)-(tert-butylamino)pyrrolidin-1-yl]pyridazin-3-yl}-5-(1H-pyrazol-4-yl)pyridin-3-ol; 2-{6-[(3S)-(tert-butylamino)pyrrolidin-1-yl]pyridazin-3-yl}-5-(1H-pyrazol-4-yl)pyridin-3-ol; 2-(6-{[(3R,4R)-3-fluoro-2,2,6,6-tetramethylpiperidin-4-yl]amino}pyridazin-3-yl)-5-[1-( 2 H 3 ) methyl-1H-pyrazol-4-yl]pyridin-3-ol; 2-(6-{[(3S,4S)-3-fluoro-2,2,6,6-tetramethylpiperidin-4-yl]amino}pyridazin-3-yl)-5-[1-( 2 H 3 ) methyl-1H-pyrazol-4-yl]pyridin-3-ol; 2-{6-[(2,2,6,6-tetramethylpiperidin-4-yl)oxy]pyridazin-3-yl}-5-(2H-1,2,3-triazol-2-yl)pyridin-3-ol; 2-{6-[(5,5-dimethyl-4-azaspiro[2.5]octan-7-yl)oxy]pyridazin-3-yl}-5-(2H-1,2,3-triazol-2-yl)pyridin-3-ol; 5-(5-fluoro-1H-pyrazol-4-yl)-2-(6-{[(3R,4S)-3-fluoro-2,2,6,6-tetramethylpiperidin-4-yl]oxy}pyridazin-3-yl)pyridin-3-ol; 5-(5-fluoro-1H-pyrazol-4-yl)-2-(6-{[(3S,4R)-3-fluoro-2,2,6,6-tetramethylpiperidin-4-yl]oxy}pyridazin-3-yl)pyridin-3-ol; 2-{6-[(3R)-3-(tert-butylamino)pyrrolidin-1-yl]pyridazin-3-yl}-5-[1-( 2 H 3 ) methyl-1H-pyrazol-4-yl]pyridin-3-ol; 2-{6-[(3R)-3-(tert-butylamino)pyrrolidin-1-yl]pyridazin-3-yl}-5-(2H-1,2,3-triazol-2-yl)pyridin-3-ol; 2-(6-{[(3R,4R)-3-fluoro-2,2,6,6-tetramethylpiperidin-4-yl]amino}pyridazin-3-yl)-5-{6-[( 2 H 3 ) methyloxy]pyrimidin-4-yl}pyridin-3-ol; 2-{6-[(5,5-dimethyl-4-azaspiro[2.5]octan-7-yl)oxy]pyridazin-3-yl}-5-(5-fluoro-1H-pyrazol-4-yl)pyridin-3-ol; 2-{6-[(5,5-dimethyl-4-azaspiro[2.5]octan-7-yl)oxy]pyridazin-3-yl}-5-(1H-pyrazol-4-yl)pyridin-3-ol; 2-{6-[(5,5-dimethyl-4-azaspiro[2.5]octan-7-yl)oxy]pyridazin-3-yl}-5-(1,3-oxazol-2-yl)pyridin-3-ol; 2-{6-[3-(tert-butylamino)pyrrolidin-1-yl]pyridazin-3-yl}-5-[1-( 2 H 3 ) methyl-1H-pyrazol-4-yl]pyridin-3-ol; 2-{6-[(3R)-3-(tert-butylamino)pyrrolidin-1-yl]pyridazin-3-yl}-5-(6-methoxypyrimidin-4-yl)pyridin-3-ol; 2-{6-[(4-azadispiro[2.1.2 5 .3 3 ]decan-9-yl)oxy]pyridazin-3-yl}-5-(1H-pyrazol-4-yl)pyridin-3-ol; 2-(6-{[(1R,3s,5S)-1,5-dimethyl-8-azabicyclo[3.2.1]octan-3-yl]oxy}pyridazin-3-yl)-5-(2H-1,2,3-triazol-2-yl)pyridin-3-ol; 2-(6-{[(1S,3r,5R)-1,5-dimethyl-8-azabicyclo[3.2.1]octan-3-yl]oxy}pyridazin-3-yl)-5-(2H-1,2,3-triazol-2-yl)pyridin-3-ol; 2-(6-{[(1R,3s,5S)-1,5-dimethyl-8-azabicyclo[3.2.1]octan-3-yl]oxy}pyridazin-3-yl)-5-[1-( 2 H 3 ) methyl-1H-pyrazol-4-yl]pyridin-3-ol; 2-(6-{[(1S,3r,5R)-1,5-dimethyl-8-azabicyclo[3.2.1]octan-3-yl]oxy}pyridazin-3-yl)-5-[1-( 2 H 3 ) methyl-1H-pyrazol-4-yl]pyridin-3-ol; 5-[6-(6-{[(3R,4S)-3-fluoro-2,2,6,6-tetramethylpiperidin-4-yl]oxy}pyridazin-3-yl)-5-hydroxypyridin-3-yl]-2-methyl-2H-indazole-7-carbonitrile; 5-[6-(6-{[(3S,4R)-3-fluoro-2,2,6,6-tetramethylpiperidin-4-yl]oxy}pyridazin-3-yl)-5-hydroxypyridin-3-yl]-2-methyl-2H-indazole-7-carbonitrile; 5-(7-fluoro-2-methyl-2H-indazol-5-yl)-2-(6-{[(3R,4S)-3-fluoro-2,2,6,6-tetramethylpiperidin-4-yl]oxy}pyridazin-3-yl)pyridin-3-ol; 5-(7-fluoro-2-methyl-2H-indazol-5-yl)-2-(6-{[(3S,4R)-3-fluoro-2,2,6,6-tetramethylpiperidin-4-yl]oxy}pyridazin-3-yl)pyridin-3-ol; 2-(6-{[(1R,3s,5S)-1,5-dimethyl-8-azabicyclo[3.2.1]octan-3-yl]oxy}pyridazin-3-yl)-5-(pyrimidin-5-yl)pyridin-3-ol; 2-(6-{[(1S,3r,5R)-1,5-dimethyl-8-azabicyclo[3.2.1]octan-3-yl]oxy}pyridazin-3-yl)-5-(pyrimidin-5-yl)pyridin-3-ol; 6-(6-{[(3R,4S)-3-fluoro-2,2,6,6-tetramethylpiperidin-4-yl]oxy}pyridazin-3-yl)-5-hydroxy-1'-methyl[3,4'-bipyridin]-2'(1'H)-one; 6-(6-{[(3S,4R)-3-fluoro-2,2,6,6-tetramethylpiperidin-4-yl]oxy}pyridazin-3-yl)-5-hydroxy-1'-methyl[3,4'-bipyridin]-2'(1'H)-one; 5-(2,8-dimethylimidazo[1,2-b]pyridazin-6-yl)-2-(6-{[(3R,4S)-3-fluoro-2,2,6,6-tetramethylpiperidin-4-yl]oxy}pyridazin-3-yl)pyridin-3-ol; 5-(2,8-dimethylimidazo[1,2-b]pyridazin-6-yl)-2-(6-{[(3S,4R)-3-fluoro-2,2,6,6-tetramethylpiperidin-4-yl]oxy}pyridazin-3-yl)pyridin-3-ol; 2-(6-{[(3S,4R)-3-fluoro-2,2,6,6-tetramethylpiperidin-4-yl]oxy}pyridazin-3-yl)-5-(1H-pyrazol-4-yl)pyridin-3-ol; 2-(6-{[(3R,4S)-3-fluoro-2,2,6,6-tetramethylpiperidin-4-yl]oxy}pyridazin-3-yl)-5-(1H-pyrazol-4-yl)pyridin-3-ol; 5-(5-fluoro-1H-pyrazol-4-yl)-2-(6-{[(3S,4R)-3-fluoro-2,2,6,6-tetramethylpiperidin-4-yl]oxy}pyridazin-3-yl)pyridin-3-ol; 2-(6-{[(3R,4S)-3-fluoro-2,2,6,6-tetramethylpiperidin-4-yl]oxy}pyridazin-3-yl)-5-(4-methyl-1H-imidazol-1-yl)pyridin-3-ol; 2-(6-{[(3S,4R)-3-fluoro-2,2,6,6-tetramethylpiperidin-4-yl]oxy}pyridazin-3-yl)-5-(4-methyl-1H-imidazol-1-yl)pyridin-3-ol; 6-[6-(6-{[(3R,4S)-3-fluoro-2,2,6,6-tetramethylpiperidin-4-yl]oxy}pyridazin-3-yl)-5-hydroxypyridin-3-yl]-3-methylpyrimidin-4(3H)-one; 6-[6-(6-{[(3S,4R)-3-fluoro-2,2,6,6-tetramethylpiperidin-4-yl]oxy}pyridazin-3-yl)-5-hydroxypyridin-3-yl]-3-methylpyrimidin-4(3H)-one; 2-(6-{[(3R,4S)-3-fluoro-2,2,6,6-tetramethylpiperidin-4-yl]oxy}pyridazin-3-yl)-5-(2-methylimidazo[1,2-a]pyridin-6-yl)pyridin-3-ol; 2-(6-{[(3S,4R)-3-fluoro-2,2,6,6-tetramethylpiperidin-4-yl]oxy}pyridazin-3-yl)-5-(2-methylimidazo[1,2-a]pyridin-6-yl)pyridin-3-ol; 5-(2,8-dimethylimidazo[1,2-a]pyridin-6-yl)-2-(6-{[(3R,4S)-3-fluoro-2,2,6,6-tetramethylpiperidin-4-yl]oxy}pyridazin-3-yl)pyridin-3-ol; 5-(2,8-dimethylimidazo[1,2-a]pyridin-6-yl)-2-(6-{[(3S,4R)-3-fluoro-2,2,6,6-tetramethylpiperidin-4-yl]oxy}pyridazin-3-yl)pyridin-3-ol; 5-(8-ethyl-2-methylimidazo[1,2-a]pyridin-6-yl)-2-(6-{[(3R,4S)-3-fluoro-2,2,6,6-tetramethylpiperidin-4-yl]oxy}pyridazin-3-yl)pyridin-3-ol; 5-(8-ethyl-2-methylimidazo[1,2-a]pyridin-6-yl)-2-(6-{[(3S,4R)-3-fluoro-2,2,6,6-tetramethylpiperidin-4-yl]oxy}pyridazin-3-yl)pyridin-3-ol; 2-(6-{[(3R,4S)-3-fluoro-2,2,6,6-tetramethylpiperidin-4-yl]oxy}pyridazin-3-yl)-5-[2-methyl-8-(trifluoromethyl)imidazo[1,2-a]pyridin-6-yl]pyridin-3-ol; 2-(6-{[(3S,4R)-3-fluoro-2,2,6,6-tetramethylpiperidin-4-yl]oxy}pyridazin-3-yl)-5-[2-methyl-8-(trifluoromethyl)imidazo[1,2-a]pyridin-6-yl]pyridin-3-ol; 5-(2,8-dimethylimidazo[1,2-b]pyridazin-6-yl)-2-(6-{[(3R,4S)-3-fluoro-2,2,6,6-tetramethylpiperidin-4-yl]oxy}pyridazin-3-yl)pyridin-3-ol; 5-(2,8-dimethylimidazo[1,2-b]pyridazin-6-yl)-2-(6-{[(3S,4R)-3-fluoro-2,2,6,6-tetramethylpiperidin-4-yl]oxy}pyridazin-3-yl)pyridin-3-ol; 2-(6-{[(3R,4S)-3-fluoro-2,2,6,6-tetramethylpiperidin-4-yl]oxy}pyridazin-3-yl)-5-(2-methylimidazo[1,2-b]pyridazin-6-yl)pyridin-3-ol; 2-(6-{[(3S,4R)-3-fluoro-2,2,6,6-tetramethylpiperidin-4-yl]oxy}pyridazin-3-yl)-5-(2-methylimidazo[1,2-b]pyridazin-6-yl)pyridin-3-ol; 2-(6-{[(3R,4S)-3-fluoro-2,2,6,6-tetramethylpiperidin-4-yl]oxy}pyridazin-3-yl)-5-(imidazo[1,2-b]pyridazin-6-yl)pyridin-3-ol; 2-(6-{[(3S,4R)-3-fluoro-2,2,6,6-tetramethylpiperidin-4-yl]oxy}pyridazin-3-yl)-5-(imidazo[1,2-b]pyridazin-6-yl)pyridin-3-ol; 5-(2,8-dimethylimidazo[1,2-b]pyridazin-6-yl)-2-{6-[(2,2,6,6-tetramethylpiperidin-4-yl)oxy]pyridazin-3-yl}pyridin-3-ol; 2-(6-{[(3R,4S)-3-fluoro-2,2,6,6-tetramethylpiperidin-4-yl]oxy}pyridazin-3-yl)-5-(1H-pyrazol-4-yl)pyridin-3-ol; 2-(6-{[(3S,4R)-3-fluoro-2,2,6,6-tetramethylpiperidin-4-yl]oxy}pyridazin-3-yl)-5-(1H-pyrazol-4-yl)pyridin-3-ol; 5-(7-fluoro-2-methyl-2H-indazol-5-yl)-2-{6-[(2,2,6,6-tetramethylpiperidin-4-yl)oxy]pyridazin-3-yl}pyridin-3-ol; 2-{6-[(5,5-dimethyl-4-azaspiro[2.5]octan-7-yl)(methyl)amino]pyridazin-3-yl}-5-[1-( 2 H 3 ) methyl-1H-pyrazol-4-yl]pyridin-3-ol; 2-(6-{[(3R,4S)-3-fluoro-2,2,6,6-tetramethylpiperidin-4-yl]oxy}pyridazin-3-yl)-5-(2-methylimidazo[1,2-a]pyrimidin-6-yl)pyridin-3-ol; 2-(6-{[(3S,4R)-3-fluoro-2,2,6,6-tetramethylpiperidin-4-yl]oxy}pyridazin-3-yl)-5-(2-methylimidazo[1,2-a]pyrimidin-6-yl)pyridin-3-ol; 2-(6-{[(3R,4S)-3-fluoro-2,2,6,6-tetramethylpiperidin-4-yl]oxy}pyridazin-3-yl)-5-(2-methyl[1,2,4]triazolo[1,5-a]pyridin-6-yl)pyridin-3-ol; 2-(6-{[(3S,4R)-3-fluoro-2,2,6,6-tetramethylpiperidin-4-yl]oxy}pyridazin-3-yl)-5-(2-methyl[1,2,4]triazolo[1,5-a]pyridin-6-yl)pyridin-3-ol; 5-(2,4-dimethyl-1,3-benzoxazol-6-yl)-2-(6-{[(3R,4S)-3-fluoro-2,2,6,6-tetramethylpiperidin-4-yl]oxy}pyridazin-3-yl)pyridin-3-ol; 5-(2,4-dimethyl-1,3-benzoxazol-6-yl)-2-(6-{[(3S,4R)-3-fluoro-2,2,6,6-tetramethylpiperidin-4-yl]oxy}pyridazin-3-yl)pyridin-3-ol; 2-(6-{[(3R,4S)-3-fluoro-2,2,6,6-tetramethylpiperidin-4-yl]oxy}pyridazin-3-yl)-5-(8-methoxy-2-methylimidazo[1,2-b]pyridazin-6-yl)pyridin-3-ol; 2-(6-{[(3S,4R)-3-fluoro-2,2,6,6-tetramethylpiperidin-4-yl]oxy}pyridazin-3-yl)-5-(8-methoxy-2-methylimidazo[1,2-b]pyridazin-6-yl)pyridin-3-ol; 5-(7-fluoro-2-methyl-2H-indazol-4-yl)-2-(6-{[(3R,4S)-3-fluoro-2,2,6,6-tetramethylpiperidin-4-yl]oxy}pyridazin-3-yl)pyridin-3-ol; 5-(7-fluoro-2-methyl-2H-indazol-4-yl)-2-(6-{[(3S,4R)-3-fluoro-2,2,6,6-tetramethylpiperidin-4-yl]oxy}pyridazin-3-yl)pyridin-3-ol; 6-[6-(6-{[(3R,4S)-3-fluoro-2,2,6,6-tetramethylpiperidin-4-yl]oxy}pyridazin-3-yl)-5-hydroxypyridin-3-yl]-2-methylimidazo[1,2-a]pyridine-8-carbonitrile; 6-[6-(6-{[(3S,4R)-3-fluoro-2,2,6,6-tetramethylpiperidin-4-yl]oxy}pyridazin-3-yl)-5-hydroxypyridin-3-yl]-2-methylimidazo[1,2-a]pyridine-8-carbonitrile; 5-(8-ethyl-2-methylimidazo[1,2-b]pyridazin-6-yl)-2-(6-{[(3R,4S)-3-fluoro-2,2,6,6-tetramethylpiperidin-4-yl]oxy}pyridazin-3-yl)pyridin-3-ol; 5-(8-ethyl-2-methylimidazo[1,2-b]pyridazin-6-yl)-2-(6-{[(3S,4R)-3-fluoro-2,2,6,6-tetramethylpiperidin-4-yl]oxy}pyridazin-3-yl)pyridin-3-ol; 2-{6-[(2,2,6,6-tetramethylpiperidin-4-yl)oxy]pyridazin-3-yl}-5-(1H-1,2,4-triazol-1-yl)pyridin-3-ol; 5-[6-(6-{[2,2,6,6-tetramethylpiperidin-4-yl]oxy}pyridazin-3-yl)-5-hydroxypyridin-3-yl]-2-methyl-2H-indazole-7-carbonitrile; 2-{6-[(2,2,6,6-tetramethylpiperidin-4-yl)oxy]pyridazin-3-yl}-5-(1H-1,2,3-triazol-1-yl)pyridin-3-ol; 2-{6-[(5,5-dimethyl-4-azaspiro[2.5]octan-7-yl)(methyl)amino]pyridazin-3-yl}-5-(7-fluoro-2-methyl-2H-indazol-5-yl)pyridin-3-ol; 5-(imidazo[1,2-b]pyridazin-6-yl)-2-{6-[(2,2,6,6-tetramethylpiperidin-4-yl)oxy]pyridazin-3-yl}pyridin-3-ol; 2-(6-{[(3R,4S)-3-fluoro-2,2,6,6-tetramethylpiperidin-4-yl]oxy}pyridazin-3-yl)-5-(imidazo[1,2-a]pyrazin-6-yl)pyridin-3-ol; 2-(6-{[(3S,4R)-3-fluoro-2,2,6,6-tetramethylpiperidin-4-yl]oxy}pyridazin-3-yl)-5-(imidazo[1,2-a]pyrazin-6-yl)pyridin-3-ol; 5-(1,3-dimethylpyrrolo[1,2-a]pyrazin-7-yl)-2-(6-{[(3R,4S)-3-fluoro-2,2,6,6-tetramethylpiperidin-4-yl]oxy}pyridazin-3-yl)pyridin-3-ol; 5-(1,3-dimethylpyrrolo[1,2-a]pyrazin-7-yl)-2-(6-{[(3S,4R)-3-fluoro-2,2,6,6-tetramethylpiperidin-4-yl]oxy}pyridazin-3-yl)pyridin-3-ol; 6-[6-(6-{[(3R,4S)-3-fluoro-2,2,6,6-tetramethylpiperidin-4-yl]oxy}pyridazin-3-yl)-5-hydroxypyridin-3-yl]-2-methylimidazo[1,2-b]pyridazine-8-carbonitrile; 6-[6-(6-{[(3S,4R)-3-fluoro-2,2,6,6-tetramethylpiperidin-4-yl]oxy}pyridazin-3-yl)-5-hydroxypyridin-3-yl]-2-methylimidazo[1,2-b]pyridazine-8-carbonitrile; 2-{6-[(3R,5S)-3,5-dimethylpiperazin-1-yl]pyridazin-3-yl}-5-(7-fluoro-2-methyl-2H-indazol-5-yl)pyridin-3-ol; 2-{6-[(3S,5R)-3,5-dimethylpiperazin-1-yl]pyridazin-3-yl}-5-(7-fluoro-2-methyl-2H-indazol-5-yl)pyridin-3-ol; 5-(6-methoxypyrimidin-4-yl)-2-{6-[(3R)-3-(methylamino)pyrrolidin-1-yl]pyridazin-3-yl}pyridin-3-ol; 2-(6-{[(1R,3s,5S)-1,5-dimethyl-8-azabicyclo[3.2.1]octan-3-yl]oxy}pyridazin-3-yl)-5-(1H-1,2,3-triazol-1-yl)pyridin-3-ol; 2-(6-{[(1S,3r,5S)-1,5-dimethyl-8-azabicyclo[3.2.1]octan-3-yl]oxy}pyridazin-3-yl)-5-(1H-1,2,3-triazol-1-yl)pyridin-3-ol; 2-(6-{[(3R,4S)-3-fluoro-2,2,6,6-tetramethylpiperidin-4-yl]oxy}pyridazin-3-yl)-5-([1,2,4]triazolo[1,5-a]pyrazin-2-yl)pyridin-3-ol; 2-(6-{[(3S,4R)-3-fluoro-2,2,6,6-tetramethylpiperidin-4-yl]oxy}pyridazin-3-yl)-5-([1,2,4]triazolo[1,5-a]pyrazin-2-yl)pyridin-3-ol; 2-{6-[(4-azadispiro[2.1.2 5 .3 3 ]decan-9-yl)oxy]pyridazin-3-yl}-5-(2H-1,2,3-triazol-2-yl)pyridin-3-ol; 5-(6-methoxypyrimidin-4-yl)-2-{6-[(2,2,6,6-tetramethylpiperidin-4-yl)oxy]pyridazin-3-yl}pyridin-3-ol; 2-{6-[(5,5-dimethyl-4-azaspiro[2.5]octan-7-yl)oxy]pyridazin-3-yl}-5-[1-( 2 H 3 ) methyl-1H-pyrazol-4-yl]pyridin-3-ol; 2-{6-[(3R)-3-(tert-butylamino)pyrrolidin-1-yl]pyridazin-3-yl}-5-(2-methyl-1,3-oxazol-5-yl)pyridin-3-ol; 2-{6-[(3R)-3-(methylamino)pyrrolidin-1-yl]pyridazin-3-yl}-5-(2-methyl-1,3-oxazol-5-yl)pyridin-3-ol; 5-(6-{6-[(3R,5S)-3,5-dimethylpiperazin-1-yl]pyridazin-3-yl}-5-hydroxypyridin-3-yl)-2-methyl-2H-indazole-7-carbonitrile; 5-(6-{6-[(3S,5R)-3,5-dimethylpiperazin-1-yl]pyridazin-3-yl}-5-hydroxypyridin-3-yl)-2-methyl-2H-indazole-7-carbonitrile; 2-{6-[(5,5-dimethyl-4-azaspiro[2.5]octan-7-yl)oxy]pyridazin-3-yl}-5-(1,3-thiazol-2-yl)pyridin-3-ol; 2-{6-[(3R)-3-(methylamino)pyrrolidin-1-yl]pyridazin-3-yl}-5-(1,3-oxazol-2-yl)pyridin-3-ol; 5-(8-methoxy-2-methylimidazo[1,2-b]pyridazin-6-yl)-2-{6-[(2,2,6,6-tetramethylpiperidin-4-yl)oxy]pyridazin-3-yl}pyridin-3-ol; 2-(6-{[(5R,7S)-5-methyl-4-azaspiro[2.5]octan-7-yl]oxy}pyridazin-3-yl)-5-[1-( 2 H 3 ) methyl-1H-pyrazol-4-yl]pyridin-3-ol; 2-(6-{[(5S,7R)-5-methyl-4-azaspiro[2.5]octan-7-yl]oxy}pyridazin-3-yl)-5-[1-( 2 H 3 ) methyl-1H-pyrazol-4-yl]pyridin-3-ol; 2-(6-{[(5S,7S)-5-methyl-4-azaspiro[2.5]octan-7-yl]oxy}pyridazin-3-yl)-5-[1-( 2 H 3 ) methyl-1H-pyrazol-4-yl]pyridin-3-ol; 2-(6-{[(5R,7R)-5-methyl-4-azaspiro[2.5]octan-7-yl]oxy}pyridazin-3-yl)-5-[1-( 2 H 3 ) methyl-1H-pyrazol-4-yl]pyridin-3-ol; 2-{6-[(3R,5S)-3,5-dimethylpiperazin-1-yl]pyridazin-3-yl}-5-(1H-pyrazol-4-yl)pyridin-3-ol; 2-{6-[(3S,5R)-3,5-dimethylpiperazin-1-yl]pyridazin-3-yl}-5-(1H-pyrazol-4-yl)pyridin-3-ol; 2-{6-[(3R,5S)-3,5-dimethylpiperazin-1-yl]pyridazin-3-yl}-5-(7-methoxy-2-methyl-2H-indazol-5-yl)pyridin-3-ol; 2-{6-[(3S,5R)-3,5-dimethylpiperazin-1-yl]pyridazin-3-yl}-5-(7-methoxy-2-methyl-2H-indazol-5-yl)pyridin-3-ol; 5-(1H-pyrazol-4-yl)-2-[6-(3,3,5,5-tetramethylpiperazin-1-yl)pyridazin-3-yl]pyridin-3-ol; 5-(7-fluoro-2-methyl-2H-indazol-5-yl)-2-[6-(3,3,5,5-tetramethylpiperazin-1-yl)pyridazin-3-yl]pyridin-3-ol; 5-(1H-pyrazol-4-yl)-2-{6-[(3R,5S)-3,4,5-trimethylpiperazin-1-yl]pyridazin-3-yl}pyridin-3-ol; 5-(1H-pyrazol-4-yl)-2-{6-[(3S,5R)-3,4,5-trimethylpiperazin-1-yl]pyridazin-3-yl}pyridin-3-ol; 5-(7-fluoro-2-methyl-2H-indazol-5-yl)-2-{6-[(3R,5S)-3,4,5-trimethylpiperazin-1-yl]pyridazin-3-yl}pyridin-3-ol; 5-(7-fluoro-2-methyl-2H-indazol-5-yl)-2-{6-[(3S,5R)-3,4,5-trimethylpiperazin-1-yl]pyridazin-3-yl}pyridin-3-ol; 2-{6-[(3R,5S)-3,5-dimethylpiperazin-1-yl]pyridazin-3-yl}-5-(2-methylimidazo[1,2-a]pyridin-6-yl)pyridin-3-ol; 2-{6-[(3S,5R)-3,5-dimethylpiperazin-1-yl]pyridazin-3-yl}-5-(2-methylimidazo[1,2-a]pyridin-6-yl)pyridin-3-ol; 5-(7-fluoro-2-methyl-2H-indazol-5-yl)-2-[6-(piperazin-1-yl)pyridazin-3-yl]pyridin-3-ol; 2-{6-[(3R,5S)-3,5-dimethylpiperazin-1-yl]pyridazin-3-yl}-5-([1,2,4]triazolo[1,5-a]pyridin-6-yl)pyridin-3-ol; 2-{6-[(3S,5R)-3,5-dimethylpiperazin-1-yl]pyridazin-3-yl}-5-([1,2,4]triazolo[1,5-a]pyridin-6-yl)pyridin-3-ol; 5-(7-methoxy-2-methyl-2H-indazol-5-yl)-2-[6-(3-methylpiperazin-1-yl)pyridazin-3-yl]pyridin-3-ol; 6-{6-[(3R,5S)-3,5-dimethylpiperazin-1-yl]pyridazin-3-yl}-2'-methoxy[3,4'-bipyridin]-5-ol; 6-{6-[(3S,5R)-3,5-dimethylpiperazin-1-yl]pyridazin-3-yl}-2'-methoxy[3,4'-bipyridin]-5-ol; 5-(7-fluoro-2-methyl-2H-indazol-5-yl)-2-[6-(3-methylpiperazin-1-yl)pyridazin-3-yl]pyridin-3-ol; 2-[6-(4,7-diazaspiro[2.5]octan-7-yl)pyridazin-3-yl]-5-(7-fluoro-2-methyl-2H-indazol-5-yl)pyridin-3-ol; 2-{6-[(3R,5S)-3,5-dimethylpiperazin-1-yl]pyridazin-3-yl}-5-(2-methyl[1,2,4]triazolo[1,5-a]pyridin-6-yl)pyridin-3-ol; 2-{6-[(3S,5R)-3,5-dimethylpiperazin-1-yl]pyridazin-3-yl}-5-(2-methyl[1,2,4]triazolo[1,5-a]pyridin-6-yl)pyridin-3-ol; 2-[6-(4-cyclopropylpiperazin-1-yl)pyridazin-3-yl]-5-(7-fluoro-2-methyl-2H-indazol-5-yl)pyridin-3-ol; 5-(7-fluoro-2-methyl-2H-indazol-5-yl)-2-[6-(4-methylpiperazin-1-yl)pyridazin-3-yl]pyridin-3-ol; [(3R,4S)-3-fluoro-4-({6-[3-hydroxy-5-(1H-pyrazol-4-yl)pyridin-2-yl]pyridazin-3-yl}oxy)-2,2,6,6-tetramethylpiperidin-1-yl]oxidanyl; 5-(7-fluoro-2-methyl-2H-indazol-5-yl)-2-{6-[(3S)-3-methylpiperazin-1-yl]pyridazin-3-yl}pyridin-3-ol; 5-(7-fluoro-2-methyl-2H-indazol-5-yl)-2-{6-[(3R)-3-methylpiperazin-1-yl]pyridazin-3-yl}pyridin-3-ol; 2-[6-(2,5-diazabicyclo[2.2.1]heptan-2-yl)pyridazin-3-yl]-5-(7-fluoro-2-methyl-2H-indazol-5-yl)pyridin-3-ol; 2-{6-[(3R,5R)-3,5-dimethylpiperazin-1-yl]pyridazin-3-yl}-5-(7-fluoro-2-methyl-2H-indazol-5-yl)pyridin-3-ol; 2-{6-[(3S,5R)-3,5-dimethylpiperazin-1-yl]pyridazin-3-yl}-5-(7-fluoro-2-methyl-2H-indazol-5-yl)pyridin-3-ol; 2-[6-(1,6-diazaspiro[3.4]octan-6-yl)pyridazin-3-yl]-5-(2-methylimidazo[1,2-a]pyridin-6-yl)pyridin-3-ol; 2-[6-(3-methylpiperazin-1-yl)pyridazin-3-yl]-5-{[(3-methyl-1H-pyrazol-4-yl)methyl]amino}pyridin-3-ol; 2-[6-(3-methylpiperazin-1-yl)pyridazin-3-yl]-5-{[(pyridin-2-yl)methyl]amino}pyridin-3-ol; 2-[6-(3-methylpiperazin-1-yl)pyridazin-3-yl]-5-{[(pyridin-3-yl)methyl]amino}pyridin-3-ol; 2-[6-(3-methylpiperazin-1-yl)pyridazin-3-yl]-5-{[(pyridin-4-yl)methyl]amino}pyridin-3-ol; 2-[6-(3-methylpiperazin-1-yl)pyridazin-3-yl]-5-{[(quinolin-3-yl)methyl]amino}pyridin-3-ol; 2-[6-(3-methylpiperazin-1-yl)pyridazin-3-yl]-5-{[(quinolin-8-yl)methyl]amino}pyridin-3-ol; 2-{6-[(6,6-dimethyl-2-oxa-5-azaspiro[3.5]nonan-8-yl)oxy]pyridazin-3-yl}-5-(1H-pyrazol-4-yl)pyridin-3-ol; 2-{6-[(3R,5S)-3,5-dimethylpiperazin-1-yl]pyridazin-3-yl}-5-(2-methylimidazo[1,2-a]pyrimidin-6-yl)pyridin-3-ol; 2-{6-[(3S,5R)-3,5-dimethylpiperazin-1-yl]pyridazin-3-yl}-5-(2-methylimidazo[1,2-a]pyrimidin-6-yl)pyridin-3-ol; 2-[6-(2,5-diazabicyclo[2.2.1]heptan-2-yl)pyridazin-3-yl]-5-(2-methylimidazo[1,2-a]pyrimidin-6-yl)pyridin-3-ol; 2-[6-(3-methylpiperazin-1-yl)pyridazin-3-yl]-5-[(pyridin-3-yl)amino]pyridin-3-ol; 2-{6-[(3R,5S)-3,5-dimethylpiperazin-1-yl]pyridazin-3-yl}-5-[(E)-2-(1-methyl-1H-pyrazol-4-yl)ethenyl]pyridin-3-ol; 2-{6-[(3S,5R)-3,5-dimethylpiperazin-1-yl]pyridazin-3-yl}-5-[(E)-2-(1-methyl-1H-pyrazol-4-yl)ethenyl]pyridin-3-ol; 2-[6-(3-ethylpiperazin-1-yl)pyridazin-3-yl]-5-(1H-pyrazol-4-yl)pyridin-3-ol; 2-[6-(3-ethylpiperazin-1-yl)pyridazin-3-yl]-5-(7-fluoro-2-methyl-2H-indazol-5-yl)pyridin-3-ol; 2-{6-[(3S)-3-(propan-2-yl)piperazin-1-yl]pyridazin-3-yl}-5-(1H-pyrazol-4-yl)pyridin-3-ol; 2-{6-[(3R)-3-(propan-2-yl)piperazin-1-yl]pyridazin-3-yl}-5-(1H-pyrazol-4-yl)pyridin-3-ol; 5-(7-fluoro-2-methyl-2H-indazol-5-yl)-2-{6-[(3S)-3-(propan-2-yl)piperazin-1-yl]pyridazin-3-yl}pyridin-3-ol; 2-[6-(3-cyclopropylpiperazin-1-yl)pyridazin-3-yl]-5-(1H-pyrazol-4-yl)pyridin-3-ol; 2-{6-[(3R,5S)-3,5-dimethylpiperazin-1-yl]pyridazin-3-yl}-5-(2-methyl-2H-indazol-5-yl)pyridin-3-ol; 2-{6-[(3S,5R)-3,5-dimethylpiperazin-1-yl]pyridazin-3-yl}-5-(2-methyl-2H-indazol-5-yl)pyridin-3-ol; 2-{6-[(3R,5S)-3,5-dimethylpiperazin-1-yl]pyridazin-3-yl}-5-[(6-methylpyridin-3-yl)amino]pyridin-3-ol; 2-{6-[(3R,5S)-3,5-dimethylpiperazin-1-yl]pyridazin-3-yl}-5-(1-methyl-1H-indazol-5-yl)pyridin-3-ol; 2-{6-[(3S,5R)-3,5-dimethylpiperazin-1-yl]pyridazin-3-yl}-5-(1-methyl-1H-indazol-5-yl)pyridin-3-ol; 5-[(6-methylpyridin-3-yl)amino]-2-{6-[(3R)-3-(propan-2-yl)piperazin-1-yl]pyridazin-3-yl}pyridin-3-ol; 5-[(6-methylpyridin-3-yl)amino]-2-{6-[(3S)-3-(propan-2-yl)piperazin-1-yl]pyridazin-3-yl}pyridin-3-ol; 2-{6-[(3S)-3-cyclopropylpiperazin-1-yl]pyridazin-3-yl}-5-(2H-1,2,3-triazol-2-yl)pyridin-3-ol; 2-{6-[(3S)-3-cyclopropylpiperazin-1-yl]pyridazin-3-yl}-5-[1-( 2 H 3 ) methyl-1H-pyrazol-4-yl]pyridin-3-ol; 2-{6-[3-(propan-2-yl)piperazin-1-yl]pyridazin-3-yl}-5-[(E)-2-(1H-pyrazol-4-yl)ethenyl]pyridin-3-ol; 2-{6-[(3R,5S)-3,5-dimethylpiperazin-1-yl]pyridazin-3-yl}-5-(2H-indazol-5-yl)pyridin-3-ol; 2-{6-[(3S,5R)-3,5-dimethylpiperazin-1-yl]pyridazin-3-yl}-5-(2H-indazol-5-yl)pyridin-3-ol; 2-{6-[(3S)-3-ethylpiperazin-1-yl]pyridazin-3-yl}-5-(1H-pyrazol-4-yl)pyridin-3-ol; 5-[(5-methylpyrazin-2-yl)amino]-2-{6-[(3R)-3-(propan-2-yl)piperazin-1-yl]pyridazin-3-yl}pyridin-3-ol; 5-[(5-methylpyrazin-2-yl)amino]-2-{6-[(3S)-3-(propan-2-yl)piperazin-1-yl]pyridazin-3-yl}pyridin-3-ol; 5-[(2-methylpyrimidin-5-yl)amino]-2-{6-[(3R)-3-(propan-2-yl)piperazin-1-yl]pyridazin-3-yl}pyridin-3-ol; and 5-[(2-methylpyrimidin-5-yl)amino]-2-{6-[(3S)-3-(propan-2-yl)piperazin-1-yl]pyridazin-3-yl}pyridin-3-ol or a form thereof, wherein the form of the compound is selected from the group consisting of a salt, a hydrate, a solvate, a racemate, an enantiomer, a diastereoisomer, and a tautomer thereof.

11. 5-(1H-pyrazol-4-yl)-2-{6-[(2,2,6,6-tetramethylpiperidin-4-yl)oxy]pyridazin-3-yl}pyridin-3-ol bistrifluoroacetate; 2-{6-[methyl(2,2,6,6-tetramethylpiperidin-4-yl)amino]pyridazin-3-yl}-5-(1H-pyrazol-4-yl)pyridin-3-ol dihydrochloride; 5-[1-( 2 H 3 ) methyl-1H-pyrazol-4-yl]-2-{6-[(2,2,6,6-tetramethylpiperidin-4-yl)oxy]pyridazin-3-yl}pyridin-3-ol hydrochloride; 2-(6-{[(3R,4R)-3-fluoro-2,2,6,6-tetramethylpiperidin-4-yl]amino}pyridazin-3-yl)-5-[1-( 2 H 3 ) methyl-1H-pyrazol-4-yl]pyridin-3-ol formate; 2-(6-{[(3S,4S)-3-fluoro-2,2,6,6-tetramethylpiperidin-4-yl]amino}pyridazin-3-yl)-5-[1-( 2 H 3 ) methyl-1H-pyrazol-4-yl]pyridin-3-ol formate; 2-{6-[(5,5-dimethyl-4-azaspiro[2.5]octan-7-yl)oxy]pyridazin-3-yl}-5-(2H-1,2,3-triazol-2-yl)pyridin-3-ol dihydrochloride; 5-(5-fluoro-1H-pyrazol-4-yl)-2-(6-{[(3R,4S)-3-fluoro-2,2,6,6-tetramethylpiperidin-4-yl]oxy}pyridazin-3-yl)pyridin-3-ol nitrile trifluoroacetate; 5-(5-fluoro-1H-pyrazol-4-yl)-2-(6-{[(3S,4R)-3-fluoro-2,2,6,6-tetramethylpiperidin-4-yl]oxy}pyridazin-3-yl)pyridin-3-ol ditrifluoroacetate; 2-(6-{[(3R,4R)-3-fluoro-2,2,6,6-tetramethylpiperidin-4-yl]amino}pyridazin-3-yl)-5-{6-[( 2 H 3 ) methyloxy]pyrimidin-4-yl}pyridin-3-ol diformate; 2-{6-[(5,5-dimethyl-4-azaspiro[2.5]octan-7-yl)oxy]pyridazin-3-yl}-5-(5-fluoro-1H-pyrazol-4-yl)pyridin-3-ol ditrifluoroacetate; 2-{6-[(5,5-dimethyl-4-azaspiro[2.5]octan-7-yl)oxy]pyridazin-3-yl}-5-(1H-pyrazol-4-yl)pyridin-3-ol dihydrochloride; 2-{6-[(5,5-dimethyl-4-azaspiro[2.5]octan-7-yl)oxy]pyridazin-3-yl}-5-(1,3-oxazol-2-yl)pyridin-3-ol dihydrochloride; 2-{6-[3-(tert-butylamino)pyrrolidin-1-yl]pyridazin-3-yl}-5-[1-( 2 H 3 ) methyl-1H-pyrazol-4-yl]pyridin-3-ol dihydrochloride; 2-{6-[(4-azadispiro[2.1.2 5 .3 3 ]decan-9-yl)oxy]pyridazin-3-yl}-5-(1H-pyrazol-4-yl)pyridin-3-ol dihydrochloride; 2-(6-{[(1R,3s,5S)-1,5-dimethyl-8-azabicyclo[3.2.1]octan-3-yl]oxy}pyridazin-3-yl)-5-(2H-1,2,3-triazol-2-yl)pyridin-3-ol dihydrochloride; 2-(6-{[(1S,3r,5R)-1,5-dimethyl-8-azabicyclo[3.2.1]octan-3-yl]oxy}pyridazin-3-yl)-5-(2H-1,2,3-triazol-2-yl)pyridin-3-ol dihydrochloride; 2-(6-{[(1R,3s,5S)-1,5-dimethyl-8-azabicyclo[3.2.1]octan-3-yl]oxy}pyridazin-3-yl)-5-(pyrimidin-5-yl)pyridin-3-ol dihydrochloride; 2-(6-{[(1S,3r,5R)-1,5-dimethyl-8-azabicyclo[3.2.1]octan-3-yl]oxy}pyridazin-3-yl)-5-(pyrimidin-5-yl)pyridin-3-ol dihydrochloride; 2-(6-{[(3S,4R)-3-fluoro-2,2,6,6-tetramethylpiperidin-4-yl]oxy}pyridazin-3-yl)-5-(1H-pyrazol-4-yl)pyridin-3-ol hydrochloride; 2-(6-{[(3S,4R)-3-fluoro-2,2,6,6-tetramethylpiperidin-4-yl]oxy}pyridazin-3-yl)-5-(1H-pyrazol-4-yl)pyridin-3-ol hydrochloride; 5-(5-fluoro-1H-pyrazol-4-yl)-2-(6-{[(3S,4R)-3-fluoro-2,2,6,6-tetramethylpiperidin-4-yl]oxy}pyridazin-3-yl)pyridin-3-ol hydrochloride; 2-(6-{[(3R,4S)-3-fluoro-2,2,6,6-tetramethylpiperidin-4-yl]oxy}pyridazin-3-yl)-5-(2-methylimidazo[1,2-a]pyridin-6-yl)pyridin-3-ol trihydrochloride; 2-(6-{[(3S,4R)-3-fluoro-2,2,6,6-tetramethylpiperidin-4-yl]oxy}pyridazin-3-yl)-5-(2-methylimidazo[1,2-a]pyridin-6-yl)pyridin-3-ol trihydrochloride; 5-(2,8-dimethylimidazo[1,2-a]pyridin-6-yl)-2-(6-{[(3R,4S)-3-fluoro-2,2,6,6-tetramethylpiperidin-4-yl]oxy}pyridazin-3-yl)pyridin-3-ol trihydrochloride; 5-(2,8-dimethylimidazo[1,2-a]pyridin-6-yl)-2-(6-{[(3S,4R)-3-fluoro-2,2,6,6-tetramethylpiperidin-4-yl]oxy}pyridazin-3-yl)pyridin-3-ol trihydrochloride; 5-(8-ethyl-2-methylimidazo[1,2-a]pyridin-6-yl)-2-(6-{[(3R,4S)-3-fluoro-2,2,6,6-tetramethylpiperidin-4-yl]oxy}pyridazin-3-yl)pyridin-3-ol trihydrochloride; 5-(8-ethyl-2-methylimidazo[1,2-a]pyridin-6-yl)-2-(6-{[(3S,4R)-3-fluoro-2,2,6,6-tetramethylpiperidin-4-yl]oxy}pyridazin-3-yl)pyridin-3-ol trihydrochloride; 2-(6-{[(3R,4S)-3-fluoro-2,2,6,6-tetramethylpiperidin-4-yl]oxy}pyridazin-3-yl)-5-[2-methyl-8-(trifluoromethyl)imidazo[1,2-a]pyridin-6-yl]pyridin-3-ol trihydrochloride; 2-(6-{[(3S,4R)-3-fluoro-2,2,6,6-tetramethylpiperidin-4-yl]oxy}pyridazin-3-yl)-5-[2-methyl-8-(trifluoromethyl)imidazo[1,2-a]pyridin-6-yl]pyridin-3-ol trihydrochloride; 2-(6-{[(3R,4S)-3-fluoro-2,2,6,6-tetramethylpiperidin-4-yl]oxy}pyridazin-3-yl)-5-(2-methylimidazo[1,2-b]pyridazin-6-yl)pyridin-3-ol dihydrochloride; 2-(6-{[(3S,4R)-3-fluoro-2,2,6,6-tetramethylpiperidin-4-yl]oxy}pyridazin-3-yl)-5-(2-methylimidazo[1,2-b]pyridazin-6-yl)pyridin-3-ol dihydrochloride; 2-(6-{[(3R,4S)-3-fluoro-2,2,6,6-tetramethylpiperidin-4-yl]oxy}pyridazin-3-yl)-5-(imidazo[1,2-b]pyridazin-6-yl)pyridin-3-ol dihydrochloride; 2-(6-{[(3S,4R)-3-fluoro-2,2,6,6-tetramethylpiperidin-4-yl]oxy}pyridazin-3-yl)-5-(imidazo[1,2-b]pyridazin-6-yl)pyridin-3-ol dihydrochloride; 5-(2,8-dimethylimidazo[1,2-b]pyridazin-6-yl)-2-{6-[(2,2,6,6-tetramethylpiperidin-4-yl)oxy]pyridazin-3-yl}pyridin-3-ol dihydrochloride; 2-(6-{[(3R,4S)-3-fluoro-2,2,6,6-tetramethylpiperidin-4-yl]oxy}pyridazin-3-yl)-5-(1H-pyrazol-4-yl)pyridin-3-ol hydrochloride; 2-(6-{[(3S,4R)-3-fluoro-2,2,6,6-tetramethylpiperidin-4-yl]oxy}pyridazin-3-yl)-5-(1H-pyrazol-4-yl)pyridin-3-ol hydrochloride; 5-(7-fluoro-2-methyl-2H-indazol-5-yl)-2-{6-[(2,2,6,6-tetramethylpiperidin-4-yl)oxy]pyridazin-3-yl}pyridin-3-ol dihydrochloride; 2-{6-[(5,5-dimethyl-4-azaspiro[2.5]octan-7-yl)(methyl)amino]pyridazin-3-yl}-5-[1-( 2 H 3 ) methyl-1H-pyrazol-4-yl]pyridin-3-ol dihydrochloride; 2-(6-{[(3R,4S)-3-fluoro-2,2,6,6-tetramethylpiperidin-4-yl]oxy}pyridazin-3-yl)-5-(2-methylimidazo[1,2-a]pyrimidin-6-yl)pyridin-3-ol trihydrochloride; 2-(6-{[(3S,4R)-3-fluoro-2,2,6,6-tetramethylpiperidin-4-yl]oxy}pyridazin-3-yl)-5-(2-methylimidazo[1,2-a]pyrimidin-6-yl)pyridin-3-ol trihydrochloride; 2-(6-{[(3R,4S)-3-fluoro-2,2,6,6-tetramethylpiperidin-4-yl]oxy}pyridazin-3-yl)-5-(2-methyl[1,2,4]triazolo[1,5-a]pyridin-6-yl)pyridin-3-ol trihydrochloride; 2-(6-{[(3S,4R)-3-fluoro-2,2,6,6-tetramethylpiperidin-4-yl]oxy}pyridazin-3-yl)-5-(2-methyl[1,2,4]triazolo[1,5-a]pyridin-6-yl)pyridin-3-ol trihydrochloride; 5-(2,4-dimethyl-1,3-benzoxazol-6-yl)-2-(6-{[(3R,4S)-3-fluoro-2,2,6,6-tetramethylpiperidin-4-yl]oxy}pyridazin-3-yl)pyridin-3-ol dihydrochloride; 5-(2,4-dimethyl-1,3-benzoxazol-6-yl)-2-(6-{[(3S,4R)-3-fluoro-2,2,6,6-tetramethylpiperidin-4-yl]oxy}pyridazin-3-yl)pyridin-3-ol dihydrochloride; 2-(6-{[(3R,4S)-3-fluoro-2,2,6,6-tetramethylpiperidin-4-yl]oxy}pyridazin-3-yl)-5-(8-methoxy-2-methylimidazo[1,2-b]pyridazin-6-yl)pyridin-3-ol dihydrochloride; 2-(6-{[(3S,4R)-3-fluoro-2,2,6,6-tetramethylpiperidin-4-yl]oxy}pyridazin-3-yl)-5-(8-methoxy-2-methylimidazo[1,2-b]pyridazin-6-yl)pyridin-3-ol dihydrochloride; 2-{6-[(2,2,6,6-tetramethylpiperidin-4-yl)oxy]pyridazin-3-yl}-5-(1H-1,2,4-triazol-1-yl)pyridin-3-ol dihydrochloride; 5-[6-(6-{[2,2,6,6-tetramethylpiperidin-4-yl]oxy}pyridazin-3-yl)-5-hydroxypyridin-3-yl]-2-methyl-2H-indazole-7-carbonitrile dihydrochloride; 2-{6-[(5,5-dimethyl-4-azaspiro[2.5]octan-7-yl)(methyl)amino]pyridazin-3-yl}-5-(7-fluoro-2-methyl-2H-indazol-5-yl)pyridin-3-ol dihydrochloride; 5-(imidazo[1,2-b]pyridazin-6-yl)-2-{6-[(2,2,6,6-tetramethylpiperidin-4-yl)oxy]pyridazin-3-yl}pyridin-3-ol dihydrochloride; 2-{6-[(3R,5S)-3,5-dimethylpiperazin-1-yl]pyridazin-3-yl}-5-(7-fluoro-2-methyl-2H-indazol-5-yl)pyridin-3-ol dihydrochloride; 2-{6-[(3S,5R)-3,5-dimethylpiperazin-1-yl]pyridazin-3-yl}-5-(7-fluoro-2-methyl-2H-indazol-5-yl)pyridin-3-ol dihydrochloride; 2-(6-{[(1R,3s,5S)-1,5-dimethyl-8-azabicyclo[3.2.1]octan-3-yl]oxy}pyridazin-3-yl)-5-(1H-1,2,3-triazol-1-yl)pyridin-3-ol hydrochloride; 2-(6-{[(1S,3r,5R)-1,5-dimethyl-8-azabicyclo[3.2.1]octan-3-yl]oxy}pyridazin-3-yl)-5-(1H-1,2,3-triazol-1-yl)pyridin-3-ol hydrochloride; 5-(6-methoxypyrimidin-4-yl)-2-{6-[(2,2,6,6-tetramethylpiperidin-4-yl)oxy]pyridazin-3-yl}pyridin-3-ol dihydrochloride; 2-{6-[(3R)-3-(tert-butylamino)pyrrolidin-1-yl]pyridazin-3-yl}-5-(2-methyl-1,3-oxazol-5-yl)pyridin-3-ol dihydrochloride; 5-(8-Methoxy-2-methylimidazo[1,2-b]pyridazin-6-yl)-2-{6-[(2,2,6,6-tetramethylpiperidin-4-yl)oxy]pyridazin-3-yl}pyridin-3-ol dihydrochloride; 2-(6-{[(5R,7S)-5-methyl-4-azaspiro[2.5]octan-7-yl]oxy}pyridazin-3-yl)-5-[1-( 2 H 3 ) methyl-1H-pyrazol-4-yl]pyridin-3-ol dihydrochloride; 2-(6-{[(5S,7S)-5-methyl-4-azaspiro[2.5]octan-7-yl]oxy}pyridazin-3-yl)-5-[1-( 2 H 3 ) methyl-1H-pyrazol-4-yl]pyridin-3-ol dihydrochloride; 2-(6-{[(5R,7R)-5-methyl-4-azaspiro[2.5]octan-7-yl]oxy}pyridazin-3-yl)-5-[1-( 2 H 3 ) methyl-1H-pyrazol-4-yl]pyridin-3-ol dihydrochloride; 2-{6-[(3R,5S)-3,5-dimethylpiperazin-1-yl]pyridazin-3-yl}-5-(1H-pyrazol-4-yl)pyridin-3-ol dihydrochloride; 2-{6-[(3S,5R)-3,5-dimethylpiperazin-1-yl]pyridazin-3-yl}-5-(1H-pyrazol-4-yl)pyridin-3-ol dihydrochloride; 2-{6-[(3R,5S)-3,5-dimethylpiperazin-1-yl]pyridazin-3-yl}-5-(7-methoxy-2-methyl-2H-indazol-5-yl)pyridin-3-ol dihydrochloride; 2-{6-[(3S,5R)-3,5-dimethylpiperazin-1-yl]pyridazin-3-yl}-5-(7-methoxy-2-methyl-2H-indazol-5-yl)pyridin-3-ol dihydrochloride; 5-(1H-pyrazol-4-yl)-2-[6-(3,3,5,5-tetramethylpiperazin-1-yl)pyridazin-3-yl]pyridin-3-ol hydrochloride; 5-(7-fluoro-2-methyl-2H-indazol-5-yl)-2-[6-(3,3,5,5-tetramethylpiperazin-1-yl)pyridazin-3-yl]pyridin-3-ol hydrochloride; 5-(1H-pyrazol-4-yl)-2-{6-[(3R,5S)-3,4,5-trimethylpiperazin-1-yl]pyridazin-3-yl}pyridin-3-ol dihydrochloride; 5-(1H-pyrazol-4-yl)-2-{6-[(3S,5R)-3,4,5-trimethylpiperazin-1-yl]pyridazin-3-yl}pyridin-3-ol dihydrochloride; 5-(7-fluoro-2-methyl-2H-indazol-5-yl)-2-{6-[(3R,5S)-3,4,5-trimethylpiperazin-1-yl]pyridazin-3-yl}pyridin-3-ol dihydrochloride; 5-(7-fluoro-2-methyl-2H-indazol-5-yl)-2-{6-[(3S,5R)-3,4,5-trimethylpiperazin-1-yl]pyridazin-3-yl}pyridin-3-ol dihydrochloride; 2-{6-[(3R,5S)-3,5-dimethylpiperazin-1-yl]pyridazin-3-yl}-5-(2-methylimidazo[1,2-a]pyridin-6-yl)pyridin-3-ol dihydrochloride; 2-{6-[(3S,5R)-3,5-dimethylpiperazin-1-yl]pyridazin-3-yl}-5-(2-methylimidazo[1,2-a]pyridin-6-yl)pyridin-3-ol dihydrochloride; 2-{6-[(3R,5S)-3,5-dimethylpiperazin-1-yl]pyridazin-3-yl}-5-([1,2,4]triazolo[1,5-a]pyridin-6-yl)pyridin-3-ol dihydrochloride; 2-{6-[(3S,5R)-3,5-dimethylpiperazin-1-yl]pyridazin-3-yl}-5-([1,2,4]triazolo[1,5-a]pyridin-6-yl)pyridin-3-ol dihydrochloride; 5-(7-Methoxy-2-methyl-2H-indazol-5-yl)-2-[6-(3-methylpiperazin-1-yl)pyridazin-3-yl]pyridin-3-ol dihydrochloride; 5-(7-fluoro-2-methyl-2H-indazol-5-yl)-2-[6-(4-methylpiperazin-1-yl)pyridazin-3-yl]pyridin-3-ol dihydrochloride; 2-[6-(2,5-diazabicyclo[2.2.1]heptan-2-yl)pyridazin-3-yl]-5-(7-fluoro-2-methyl-2H-indazol-5-yl)pyridin-3-ol hydrochloride; 2-[6-(1,6-diazaspiro[3.4]octan-6-yl)pyridazin-3-yl]-5-(2-methylimidazo[1,2-a]pyridin-6-yl)pyridin-3-ol dihydrochloride; 2-[6-(3-methylpiperazin-1-yl)pyridazin-3-yl]-5-{[(3-methyl-1H-pyrazol-4-yl)methyl]amino}pyridin-3-ol dihydrochloride; 2-[6-(3-methylpiperazin-1-yl)pyridazin-3-yl]-5-{[(pyridin-2-yl)methyl]amino}pyridin-3-ol dihydrochloride; 2-[6-(3-methylpiperazin-1-yl)pyridazin-3-yl]-5-{[(pyridin-3-yl)methyl]amino}pyridin-3-ol dihydrochloride; 2-[6-(3-methylpiperazin-1-yl)pyridazin-3-yl]-5-{[(pyridin-4-yl)methyl]amino}pyridin-3-ol 2-[6-(3-methylpiperazin-1-yl)pyridazin-3-yl]-5-{[(quinolin-3-yl)methyl]amino}pyridin-3-ol dihydrochloride; 2-[6-(3-methylpiperazin-1-yl)pyridazin-3-yl]-5-{[(quinolin-8-yl)methyl]amino}pyridin-3-ol dihydrochloride; 2-{6-[(3R,5S)-3,5-dimethylpiperazin-1-yl]pyridazin-3-yl}-5-(2-methylimidazo[1,2-a]pyrimidin-6-yl)pyridin-3-ol trifluoroacetate; 2-{6-[(3S,5R)-3,5-dimethylpiperazin-1-yl]pyridazin-3-yl}-5-(2-methylimidazo[1,2-a]pyrimidin-6-yl)pyridin-3-ol trifluoroacetate; 2-[6-(2,5-diazabicyclo[2.2.1]heptan-2-yl)pyridazin-3-yl]-5-(2-methylimidazo[1,2-a]pyrimidin-6-yl)pyridin-3-ol trifluoroacetate; 2-[6-(3-methylpiperazin-1-yl)pyridazin-3-yl]-5-[(pyridin-3-yl)amino]pyridin-3-ol dihydrochloride; 2-{6-[(3R,5S)-3,5-dimethylpiperazin-1-yl]pyridazin-3-yl}-5-[(E)-2-(1-methyl-1H-pyrazol-4-yl)ethenyl]pyridin-3-ol dihydrochloride; 2-{6-[(3S,5R)-3,5-dimethylpiperazin-1-yl]pyridazin-3-yl}-5-[(E)-2-(1-methyl-1H-pyrazol-4-yl)ethenyl]pyridin-3-ol dihydrochloride; 2-[6-(3-ethylpiperazin-1-yl)pyridazin-3-yl]-5-(1H-pyrazol-4-yl)pyridin-3-ol dihydrochloride; 2-[6-(3-ethylpiperazin-1-yl)pyridazin-3-yl]-5-(7-fluoro-2-methyl-2H-indazol-5-yl)pyridin-3-ol dihydrochloride; 2-{6-[(3S)-3-(propan-2-yl)piperazin-1-yl]pyridazin-3-yl}-5-(1H-pyrazol-4-yl)pyridin-3-ol dihydrochloride; 2-{6-[(3R)-3-(propan-2-yl)piperazin-1-yl]pyridazin-3-yl}-5-(1H-pyrazol-4-yl)pyridin-3-ol dihydrochloride; 5-(7-fluoro-2-methyl-2H-indazol-5-yl)-2-{6-[(3S)-3-(propan-2-yl)piperazin-1-yl]pyridazin-3-yl}pyridin-3-ol dihydrochloride; 2-[6-(3-cyclopropylpiperazin-1-yl)pyridazin-3-yl]-5-(1H-pyrazol-4-yl)pyridin-3-ol dihydrochloride; 2-{6-[(3R,5S)-3,5-dimethylpiperazin-1-yl]pyridazin-3-yl}-5-[(6-methylpyridin-3-yl)amino]pyridin-3-ol dihydrochloride; 2-{6-[(3R,5S)-3,5-dimethylpiperazin-1-yl]pyridazin-3-yl}-5-(1-methyl-1H-indazol-5-yl)pyridin-3-ol dihydrochloride; 2-{6-[(3S,5R)-3,5-dimethylpiperazin-1-yl]pyridazin-3-yl}-5-(1-methyl-1H-indazol-5-yl)pyridin-3-ol dihydrochloride; 5-[(6-methylpyridin-3-yl)amino]-2-{6-[(3R)-3-(propan-2-yl)piperazin-1-yl]pyridazin-3-yl}pyridin-3-ol dihydrochloride; 5-[(6-methylpyridin-3-yl)amino]-2-{6-[(3S)-3-(propan-2-yl)piperazin-1-yl]pyridazin-3-yl}pyridin-3-ol dihydrochloride; 2-{6-[(3S)-3-cyclopropylpiperazin-1-yl]pyridazin-3-yl}-5-(2H-1,2,3-triazol-2-yl)pyridin-3-ol dihydrochloride; 2-{6-[(3S)-3-cyclopropylpiperazin-1-yl]pyridazin-3-yl}-5-[1-( 2 H 3 ) methyl-1H-pyrazol-4-yl]pyridin-3-ol dihydrochloride; 2-{6-[3-(propan-2-yl)piperazin-1-yl]pyridazin-3-yl}-5-[(E)-2-(1H-pyrazol-4-yl)ethenyl]pyridin-3-ol dihydrochloride; 2-{6-[(3R,5S)-3,5-dimethylpiperazin-1-yl]pyridazin-3-yl}-5-(2H-indazol-5-yl)pyridin-3-ol dihydrochloride; 2-{6-[(3S,5R)-3,5-dimethylpiperazin-1-yl]pyridazin-3-yl}-5-(2H-indazol-5-yl)pyridin-3-ol dihydrochloride; 2-{6-[(3S)-3-ethylpiperazin-1-yl]pyridazin-3-yl}-5-(1H-pyrazol-4-yl)pyridin-3-ol dihydrochloride; 5-[(5-methylpyrazin-2-yl)amino]-2-{6-[(3R)-3-(propan-2-yl)piperazin-1-yl]pyridazin-3-yl}pyridin-3-ol dihydrochloride; 5-[(5-methylpyrazin-2-yl)amino]-2-{6-[(3S)-3-(propan-2-yl)piperazin-1-yl]pyridazin-3-yl}pyridin-3-ol dihydrochloride; 5-[(2-methylpyrimidin-5-yl)amino]-2-{6-[(3R)-3-(propan-2-yl)piperazin-1-yl]pyridazin-3-yl}pyridin-3-ol dihydrochloride; 5-[(2-methylpyrimidin-5-yl)amino]-2-{6-[(3S)-3-(propan-2-yl)piperazin-1-yl]pyridazin-3-yl}pyridin-3-ol dihydrochloride; 2-{3-[methyl(2,2,6,6-tetramethylpiperidin-4-yl)amino]-1,2,4-triazin-6-yl}-5-(1H-pyrazol-4-yl)pyridin-3-ol trifluoroacetate; 2-{3-[3-(tert-butylamino)pyrrolidin-1-yl]-1,2,4-triazin-6-yl}-5-(1H-pyrazol-4-yl)pyridin-3-ol diformate; 2-{3-[3-(tert-butylamino)pyrrolidin-1-yl]-1,2,4-triazin-6-yl}-5-[1-( 2 H 3 ) methyl-1H-pyrazol-4-yl]pyridin-3-ol diformate; 2-{3-[3-(tert-butylamino)pyrrolidin-1-yl]-1,2,4-triazin-6-yl}-5-(2H-1,2,3-triazol-2-yl)pyridin-3-ol nitrile trifluoroacetate; 2-(3-{[(3S,4S)-3-fluoro-2,2,6,6-tetramethylpiperidin-4-yl]amino}-1,2,4-triazin-6-yl)-5-(1H-pyrazol-4-yl)pyridin-3-ol trihydrochloride; 2-(3-{[(3R,4R)-3-fluoro-2,2,6,6-tetramethylpiperidin-4-yl]amino}-1,2,4-triazin-6-yl)-5-(1H-pyrazol-4-yl)pyridin-3-ol trihydrochloride; 5-(1H-pyrazol-4-yl)-2-{3-[(2,2,6,6-tetramethylpiperidin-4-yl)oxy]-1,2,4-triazin-6-yl}pyridin-3-ol trifluoroacetate; 5-[1-( 2 H 3 ) methyl-1H-pyrazol-4-yl]-2-{3-[methyl(2,2,6,6-tetramethylpiperidin-4-yl)amino]-1,2,4-triazin-6-yl}pyridin-3-ol bistrifluoroacetate; 5-(5-fluoro-1H-pyrazol-4-yl)-2-{3-[methyl(2,2,6,6-tetramethylpiperidin-4-yl)amino]-1,2,4-triazin-6-yl}pyridin-3-ol ditrifluoroacetate; 2-{3-[methyl(2,2,6,6-tetramethylpiperidin-4-yl)amino]-1,2,4-triazin-6-yl}-5-(2H-1,2,3-triazol-2-yl)pyridin-3-ol nitrile trifluoroacetate; 2-{3-[(3S)-3-(tert-butylamino)pyrrolidin-1-yl]-1,2,4-triazin-6-yl}-5-(3-fluoro-1H-pyrazol-4-yl)pyridin-3-ol hydrochloride; 2-{3-[(3R)-3-(tert-butylamino)pyrrolidin-1-yl]-1,2,4-triazin-6-yl}-5-(7-methoxy-2-methyl-2H-indazol-5-yl)pyridin-3-ol hydrochloride; 6-(6-{3-[(3R)-3-(tert-butylamino)pyrrolidin-1-yl]-1,2,4-triazin-6-yl}-5-hydroxypyridin-3-yl)-2-methylimidazo[1,2-a]pyridine-8-carbonitrile hydrochloride; 2-{3-[(3R)-3-(tert-butylamino)pyrrolidin-1-yl]-1,2,4-triazin-6-yl}-5-(8-ethyl-2-methylimidazo[1,2-a]pyridin-6-yl)pyridin-3-ol hydrochloride; 2-{3-[(3R)-3-(tert-butylamino)pyrrolidin-1-yl]-1,2,4-triazin-6-yl}-5-(2,8-dimethylimidazo[1,2-b]pyridazin-6-yl)pyridin-3-ol hydrochloride; 5-(7-methoxy-2-methyl-2H-indazol-5-yl)-2-[3-(4-methylpiperazin-1-yl)-1,2,4-triazin-6-yl]pyridin-3-ol hydrochloride; 5-(8-fluoro-2-methylimidazo[1,2-a]pyridin-6-yl)-2-[3-(4-methylpiperazin-1-yl)-1,2,4-triazin-6-yl]pyridin-3-ol hydrochloride; 2-[3-(4-methylpiperazin-1-yl)-1,2,4-triazin-6-yl]-5-(1H-pyrazol-4-yl)pyridin-3-ol hydrochloride; 5-(2,8-dimethylimidazo[1,2-a]pyridin-6-yl)-2-[3-(4-methylpiperazin-1-yl)-1,2,4-triazin-6-yl]pyridin-3-ol hydrochloride; 5-[(5-methylpyrazin-2-yl)amino]-2-{3-[(3S)-3-(propan-2-yl)piperazin-1-yl]-1,2,4-triazin-6-yl}pyridin-3-ol dihydrochloride; 5-(7-fluoro-2-methyl-2H-indazol-5-yl)-2-{3-[(3S)-3-(propan-2-yl)piperazin-1-yl]-1,2,4-triazin-6-yl}pyridin-3-ol hydrochloride; 2-{3-[(3S)-3-(propan-2-yl)piperazin-1-yl]-1,2,4-triazin-6-yl}-5-(2H-1,2,3-triazol-2-yl)pyridin-3-ol hydrochloride; 2-{3-[(3S)-3-cyclopropylpiperazin-1-yl]-1,2,4-triazin-6-yl}-5-(2-methyl-2H-[1,2,3]triazolo[4,5-b]pyridin-6-yl)pyridin-3-ol trifluoroacetate; 2-{3-[(3S)-3-cyclopropylpiperazin-1-yl]-1,2,4-triazin-6-yl}-5-(7-fluoro-2-methyl-2H-indazol-5-yl)pyridin-3-ol hydrochloride; 2-{3-[(3S)-3-cyclopropylpiperazin-1-yl]-1,2,4-triazin-6-yl}-5-(2H-1,2,3-triazol-2-yl)pyridin-3-ol trifluoroacetate; and 2-{3-[(3S)-3-cyclopropylpiperazin-1-yl]-1,2,4-triazin-6-yl}-5-[(5-methylpyrazin-2-yl)amino]pyridin-3-ol hydrochloride or a form thereof, wherein the salt form of said compound is selected from the group consisting of a hydrate, solvate, racemate, enantiomer, diastereoisomer, and tautomer form thereof.

12. 5-(1H-pyrazol-4-yl)-2-{6-[(2,2,6,6-tetramethylpiperidin-4-yl)oxy]pyridazin-3-yl}pyridin-3-ol bistrifluoroacetate; 2-{6-[methyl(2,2,6,6-tetramethylpiperidin-4-yl)amino]pyridazin-3-yl}-5-(1H-pyrazol-4-yl)pyridin-3-ol dihydrochloride; 5-[1-( 2 H 3 ) methyl-1H-pyrazol-4-yl]-2-{6-[(2,2,6,6-tetramethylpiperidin-4-yl)oxy]pyridazin-3-yl}pyridin-3-ol hydrochloride; 2-(6-{[(3R,4R)-3-fluoro-2,2,6,6-tetramethylpiperidin-4-yl]amino}pyridazin-3-yl)-5-[1-( 2 H 3 ) methyl-1H-pyrazol-4-yl]pyridin-3-ol formate; 2-(6-{[(3S,4S)-3-fluoro-2,2,6,6-tetramethylpiperidin-4-yl]amino}pyridazin-3-yl)-5-[1-( 2 H 3 ) methyl-1H-pyrazol-4-yl]pyridin-3-ol formate; 2-{6-[(5,5-dimethyl-4-azaspiro[2.5]octan-7-yl)oxy]pyridazin-3-yl}-5-(2H-1,2,3-triazol-2-yl)pyridin-3-ol dihydrochloride; 5-(5-fluoro-1H-pyrazol-4-yl)-2-(6-{[(3R,4S)-3-fluoro-2,2,6,6-tetramethylpiperidin-4-yl]oxy}pyridazin-3-yl)pyridin-3-ol nitrile trifluoroacetate; 5-(5-fluoro-1H-pyrazol-4-yl)-2-(6-{[(3S,4R)-3-fluoro-2,2,6,6-tetramethylpiperidin-4-yl]oxy}pyridazin-3-yl)pyridin-3-ol ditrifluoroacetate; 2-(6-{[(3R,4R)-3-fluoro-2,2,6,6-tetramethylpiperidin-4-yl]amino}pyridazin-3-yl)-5-{6-[( 2 H 3 ) methyloxy]pyrimidin-4-yl}pyridin-3-ol diformate; 2-{6-[(5,5-dimethyl-4-azaspiro[2.5]octan-7-yl)oxy]pyridazin-3-yl}-5-(5-fluoro-1H-pyrazol-4-yl)pyridin-3-ol ditrifluoroacetate; 2-{6-[(5,5-dimethyl-4-azaspiro[2.5]octan-7-yl)oxy]pyridazin-3-yl}-5-(1H-pyrazol-4-yl)pyridin-3-ol dihydrochloride; 2-{6-[(5,5-dimethyl-4-azaspiro[2.5]octan-7-yl)oxy]pyridazin-3-yl}-5-(1,3-oxazol-2-yl)pyridin-3-ol dihydrochloride; 2-{6-[3-(tert-butylamino)pyrrolidin-1-yl]pyridazin-3-yl}-5-[1-( 2 H 3 ) methyl-1H-pyrazol-4-yl]pyridin-3-ol dihydrochloride; 2-{6-[(4-azadispiro[2.1.2 5 .3 3 ]decan-9-yl)oxy]pyridazin-3-yl}-5-(1H-pyrazol-4-yl)pyridin-3-ol dihydrochloride; 2-(6-{[(1R,3s,5S)-1,5-dimethyl-8-azabicyclo[3.2.1]octan-3-yl]oxy}pyridazin-3-yl)-5-(2H-1,2,3-triazol-2-yl)pyridin-3-ol dihydrochloride; 2-(6-{[(1S,3r,5R)-1,5-dimethyl-8-azabicyclo[3.2.1]octan-3-yl]oxy}pyridazin-3-yl)-5-(2H-1,2,3-triazol-2-yl)pyridin-3-ol dihydrochloride; 2-(6-{[(1R,3s,5S)-1,5-dimethyl-8-azabicyclo[3.2.1]octan-3-yl]oxy}pyridazin-3-yl)-5-(pyrimidin-5-yl)pyridin-3-ol dihydrochloride; 2-(6-{[(1S,3r,5R)-1,5-dimethyl-8-azabicyclo[3.2.1]octan-3-yl]oxy}pyridazin-3-yl)-5-(pyrimidin-5-yl)pyridin-3-ol dihydrochloride; 2-(6-{[(3S,4R)-3-fluoro-2,2,6,6-tetramethylpiperidin-4-yl]oxy}pyridazin-3-yl)-5-(1H-pyrazol-4-yl)pyridin-3-ol hydrochloride; 2-(6-{[(3S,4R)-3-fluoro-2,2,6,6-tetramethylpiperidin-4-yl]oxy}pyridazin-3-yl)-5-(1H-pyrazol-4-yl)pyridin-3-ol hydrochloride; 5-(5-fluoro-1H-pyrazol-4-yl)-2-(6-{[(3S,4R)-3-fluoro-2,2,6,6-tetramethylpiperidin-4-yl]oxy}pyridazin-3-yl)pyridin-3-ol hydrochloride; 2-(6-{[(3R,4S)-3-fluoro-2,2,6,6-tetramethylpiperidin-4-yl]oxy}pyridazin-3-yl)-5-(2-methylimidazo[1,2-a]pyridin-6-yl)pyridin-3-ol trihydrochloride; 2-(6-{[(3S,4R)-3-fluoro-2,2,6,6-tetramethylpiperidin-4-yl]oxy}pyridazin-3-yl)-5-(2-methylimidazo[1,2-a]pyridin-6-yl)pyridin-3-ol trihydrochloride; 5-(2,8-dimethylimidazo[1,2-a]pyridin-6-yl)-2-(6-{[(3R,4S)-3-fluoro-2,2,6,6-tetramethylpiperidin-4-yl]oxy}pyridazin-3-yl)pyridin-3-ol trihydrochloride; 5-(2,8-dimethylimidazo[1,2-a]pyridin-6-yl)-2-(6-{[(3S,4R)-3-fluoro-2,2,6,6-tetramethylpiperidin-4-yl]oxy}pyridazin-3-yl)pyridin-3-ol trihydrochloride; 5-(8-ethyl-2-methylimidazo[1,2-a]pyridin-6-yl)-2-(6-{[(3R,4S)-3-fluoro-2,2,6,6-tetramethylpiperidin-4-yl]oxy}pyridazin-3-yl)pyridin-3-ol trihydrochloride; 5-(8-ethyl-2-methylimidazo[1,2-a]pyridin-6-yl)-2-(6-{[(3S,4R)-3-fluoro-2,2,6,6-tetramethylpiperidin-4-yl]oxy}pyridazin-3-yl)pyridin-3-ol trihydrochloride; 2-(6-{[(3R,4S)-3-fluoro-2,2,6,6-tetramethylpiperidin-4-yl]oxy}pyridazin-3-yl)-5-[2-methyl-8-(trifluoromethyl)imidazo[1,2-a]pyridin-6-yl]pyridin-3-ol trihydrochloride; 2-(6-{[(3S,4R)-3-fluoro-2,2,6,6-tetramethylpiperidin-4-yl]oxy}pyridazin-3-yl)-5-[2-methyl-8-(trifluoromethyl)imidazo[1,2-a]pyridin-6-yl]pyridin-3-ol trihydrochloride; 2-(6-{[(3R,4S)-3-fluoro-2,2,6,6-tetramethylpiperidin-4-yl]oxy}pyridazin-3-yl)-5-(2-methylimidazo[1,2-b]pyridazin-6-yl)pyridin-3-ol dihydrochloride; 2-(6-{[(3S,4R)-3-fluoro-2,2,6,6-tetramethylpiperidin-4-yl]oxy}pyridazin-3-yl)-5-(2-methylimidazo[1,2-b]pyridazin-6-yl)pyridin-3-ol dihydrochloride; 2-(6-{[(3R,4S)-3-fluoro-2,2,6,6-tetramethylpiperidin-4-yl]oxy}pyridazin-3-yl)-5-(imidazo[1,2-b]pyridazin-6-yl)pyridin-3-ol dihydrochloride; 2-(6-{[(3S,4R)-3-fluoro-2,2,6,6-tetramethylpiperidin-4-yl]oxy}pyridazin-3-yl)-5-(imidazo[1,2-b]pyridazin-6-yl)pyridin-3-ol dihydrochloride; 5-(2,8-dimethylimidazo[1,2-b]pyridazin-6-yl)-2-{6-[(2,2,6,6-tetramethylpiperidin-4-yl)oxy]pyridazin-3-yl}pyridin-3-ol dihydrochloride; 2-(6-{[(3R,4S)-3-fluoro-2,2,6,6-tetramethylpiperidin-4-yl]oxy}pyridazin-3-yl)-5-(1H-pyrazol-4-yl)pyridin-3-ol hydrochloride; 2-(6-{[(3S,4R)-3-fluoro-2,2,6,6-tetramethylpiperidin-4-yl]oxy}pyridazin-3-yl)-5-(1H-pyrazol-4-yl)pyridin-3-ol hydrochloride; 5-(7-fluoro-2-methyl-2H-indazol-5-yl)-2-{6-[(2,2,6,6-tetramethylpiperidin-4-yl)oxy]pyridazin-3-yl}pyridin-3-ol dihydrochloride; 2-{6-[(5,5-dimethyl-4-azaspiro[2.5]octan-7-yl)(methyl)amino]pyridazin-3-yl}-5-[1-( 2 H 3 ) methyl-1H-pyrazol-4-yl]pyridin-3-ol dihydrochloride; 2-(6-{[(3R,4S)-3-fluoro-2,2,6,6-tetramethylpiperidin-4-yl]oxy}pyridazin-3-yl)-5-(2-methylimidazo[1,2-a]pyrimidin-6-yl)pyridin-3-ol trihydrochloride; 2-(6-{[(3S,4R)-3-fluoro-2,2,6,6-tetramethylpiperidin-4-yl]oxy}pyridazin-3-yl)-5-(2-methylimidazo[1,2-a]pyrimidin-6-yl)pyridin-3-ol trihydrochloride; 2-(6-{[(3R,4S)-3-fluoro-2,2,6,6-tetramethylpiperidin-4-yl]oxy}pyridazin-3-yl)-5-(2-methyl[1,2,4]triazolo[1,5-a]pyridin-6-yl)pyridin-3-ol trihydrochloride; 2-(6-{[(3S,4R)-3-fluoro-2,2,6,6-tetramethylpiperidin-4-yl]oxy}pyridazin-3-yl)-5-(2-methyl[1,2,4]triazolo[1,5-a]pyridin-6-yl)pyridin-3-ol trihydrochloride; 5-(2,4-dimethyl-1,3-benzoxazol-6-yl)-2-(6-{[(3R,4S)-3-fluoro-2,2,6,6-tetramethylpiperidin-4-yl]oxy}pyridazin-3-yl)pyridin-3-ol dihydrochloride; 5-(2,4-dimethyl-1,3-benzoxazol-6-yl)-2-(6-{[(3S,4R)-3-fluoro-2,2,6,6-tetramethylpiperidin-4-yl]oxy}pyridazin-3-yl)pyridin-3-ol dihydrochloride; 2-(6-{[(3R,4S)-3-fluoro-2,2,6,6-tetramethylpiperidin-4-yl]oxy}pyridazin-3-yl)-5-(8-methoxy-2-methylimidazo[1,2-b]pyridazin-6-yl)pyridin-3-ol dihydrochloride; 2-(6-{[(3S,4R)-3-fluoro-2,2,6,6-tetramethylpiperidin-4-yl]oxy}pyridazin-3-yl)-5-(8-methoxy-2-methylimidazo[1,2-b]pyridazin-6-yl)pyridin-3-ol dihydrochloride; 2-{6-[(2,2,6,6-tetramethylpiperidin-4-yl)oxy]pyridazin-3-yl}-5-(1H-1,2,4-triazol-1-yl)pyridin-3-ol dihydrochloride; 5-[6-(6-{[2,2,6,6-tetramethylpiperidin-4-yl]oxy}pyridazin-3-yl)-5-hydroxypyridin-3-yl]-2-methyl-2H-indazole-7-carbonitrile dihydrochloride; 2-{6-[(5,5-dimethyl-4-azaspiro[2.5]octan-7-yl)(methyl)amino]pyridazin-3-yl}-5-(7-fluoro-2-methyl-2H-indazol-5-yl)pyridin-3-ol dihydrochloride; 5-(imidazo[1,2-b]pyridazin-6-yl)-2-{6-[(2,2,6,6-tetramethylpiperidin-4-yl)oxy]pyridazin-3-yl}pyridin-3-ol dihydrochloride; 2-{6-[(3R,5S)-3,5-dimethylpiperazin-1-yl]pyridazin-3-yl}-5-(7-fluoro-2-methyl-2H-indazol-5-yl)pyridin-3-ol dihydrochloride; 2-{6-[(3S,5R)-3,5-dimethylpiperazin-1-yl]pyridazin-3-yl}-5-(7-fluoro-2-methyl-2H-indazol-5-yl)pyridin-3-ol dihydrochloride; 2-(6-{[(1R,3s,5S)-1,5-dimethyl-8-azabicyclo[3.2.1]octan-3-yl]oxy}pyridazin-3-yl)-5-(1H-1,2,3-triazol-1-yl)pyridin-3-ol hydrochloride; 2-(6-{[(1S,3r,5R)-1,5-dimethyl-8-azabicyclo[3.2.1]octan-3-yl]oxy}pyridazin-3-yl)-5-(1H-1,2,3-triazol-1-yl)pyridin-3-ol hydrochloride; 5-(6-methoxypyrimidin-4-yl)-2-{6-[(2,2,6,6-tetramethylpiperidin-4-yl)oxy]pyridazin-3-yl}pyridin-3-ol dihydrochloride; 2-{6-[(3R)-3-(tert-butylamino)pyrrolidin-1-yl]pyridazin-3-yl}-5-(2-methyl-1,3-oxazol-5-yl)pyridin-3-ol dihydrochloride; 5-(8-Methoxy-2-methylimidazo[1,2-b]pyridazin-6-yl)-2-{6-[(2,2,6,6-tetramethylpiperidin-4-yl)oxy]pyridazin-3-yl}pyridin-3-ol dihydrochloride; 2-(6-{[(5R,7S)-5-methyl-4-azaspiro[2.5]octan-7-yl]oxy}pyridazin-3-yl)-5-[1-( 2 H 3 ) methyl-1H-pyrazol-4-yl]pyridin-3-ol dihydrochloride; 2-(6-{[(5S,7S)-5-methyl-4-azaspiro[2.5]octan-7-yl]oxy}pyridazin-3-yl)-5-[1-( 2 H 3 ) methyl-1H-pyrazol-4-yl]pyridin-3-ol dihydrochloride; 2-(6-{[(5R,7R)-5-methyl-4-azaspiro[2.5]octan-7-yl]oxy}pyridazin-3-yl)-5-[1-( 2 H 3 ) methyl-1H-pyrazol-4-yl]pyridin-3-ol dihydrochloride; 2-{6-[(3R,5S)-3,5-dimethylpiperazin-1-yl]pyridazin-3-yl}-5-(1H-pyrazol-4-yl)pyridin-3-ol dihydrochloride; 2-{6-[(3S,5R)-3,5-dimethylpiperazin-1-yl]pyridazin-3-yl}-5-(1H-pyrazol-4-yl)pyridin-3-ol dihydrochloride; 2-{6-[(3R,5S)-3,5-dimethylpiperazin-1-yl]pyridazin-3-yl}-5-(7-methoxy-2-methyl-2H-indazol-5-yl)pyridin-3-ol dihydrochloride; 2-{6-[(3S,5R)-3,5-dimethylpiperazin-1-yl]pyridazin-3-yl}-5-(7-methoxy-2-methyl-2H-indazol-5-yl)pyridin-3-ol dihydrochloride; 5-(1H-pyrazol-4-yl)-2-[6-(3,3,5,5-tetramethylpiperazin-1-yl)pyridazin-3-yl]pyridin-3-ol hydrochloride; 5-(7-fluoro-2-methyl-2H-indazol-5-yl)-2-[6-(3,3,5,5-tetramethylpiperazin-1-yl)pyridazin-3-yl]pyridin-3-ol hydrochloride; 5-(1H-pyrazol-4-yl)-2-{6-[(3R,5S)-3,4,5-trimethylpiperazin-1-yl]pyridazin-3-yl}pyridin-3-ol dihydrochloride; 5-(1H-pyrazol-4-yl)-2-{6-[(3S,5R)-3,4,5-trimethylpiperazin-1-yl]pyridazin-3-yl}pyridin-3-ol dihydrochloride; 5-(7-fluoro-2-methyl-2H-indazol-5-yl)-2-{6-[(3R,5S)-3,4,5-trimethylpiperazin-1-yl]pyridazin-3-yl}pyridin-3-ol dihydrochloride; 5-(7-fluoro-2-methyl-2H-indazol-5-yl)-2-{6-[(3S,5R)-3,4,5-trimethylpiperazin-1-yl]pyridazin-3-yl}pyridin-3-ol dihydrochloride; 2-{6-[(3R,5S)-3,5-dimethylpiperazin-1-yl]pyridazin-3-yl}-5-(2-methylimidazo[1,2-a]pyridin-6-yl)pyridin-3-ol dihydrochloride; 2-{6-[(3S,5R)-3,5-dimethylpiperazin-1-yl]pyridazin-3-yl}-5-(2-methylimidazo[1,2-a]pyridin-6-yl)pyridin-3-ol dihydrochloride; 2-{6-[(3R,5S)-3,5-dimethylpiperazin-1-yl]pyridazin-3-yl}-5-([1,2,4]triazolo[1,5-a]pyridin-6-yl)pyridin-3-ol dihydrochloride; 2-{6-[(3S,5R)-3,5-dimethylpiperazin-1-yl]pyridazin-3-yl}-5-([1,2,4]triazolo[1,5-a]pyridin-6-yl)pyridin-3-ol dihydrochloride; 5-(7-Methoxy-2-methyl-2H-indazol-5-yl)-2-[6-(3-methylpiperazin-1-yl)pyridazin-3-yl]pyridin-3-ol dihydrochloride; 5-(7-fluoro-2-methyl-2H-indazol-5-yl)-2-[6-(4-methylpiperazin-1-yl)pyridazin-3-yl]pyridin-3-ol dihydrochloride; 2-[6-(2,5-diazabicyclo[2.2.1]heptan-2-yl)pyridazin-3-yl]-5-(7-fluoro-2-methyl-2H-indazol-5-yl)pyridin-3-ol hydrochloride; 2-[6-(1,6-diazaspiro[3.4]octan-6-yl)pyridazin-3-yl]-5-(2-methylimidazo[1,2-a]pyridin-6-yl)pyridin-3-ol dihydrochloride; 2-[6-(3-methylpiperazin-1-yl)pyridazin-3-yl]-5-{[(3-methyl-1H-pyrazol-4-yl)methyl]amino}pyridin-3-ol dihydrochloride; 2-[6-(3-methylpiperazin-1-yl)pyridazin-3-yl]-5-{[(pyridin-2-yl)methyl]amino}pyridin-3-ol dihydrochloride; 2-[6-(3-methylpiperazin-1-yl)pyridazin-3-yl]-5-{[(pyridin-3-yl)methyl]amino}pyridin-3-ol dihydrochloride; 2-[6-(3-methylpiperazin-1-yl)pyridazin-3-yl]-5-{[(pyridin-4-yl)methyl]amino}pyridin-3-ol 2-[6-(3-methylpiperazin-1-yl)pyridazin-3-yl]-5-{[(quinolin-3-yl)methyl]amino}pyridin-3-ol dihydrochloride; 2-[6-(3-methylpiperazin-1-yl)pyridazin-3-yl]-5-{[(quinolin-8-yl)methyl]amino}pyridin-3-ol dihydrochloride; 2-{6-[(3R,5S)-3,5-dimethylpiperazin-1-yl]pyridazin-3-yl}-5-(2-methylimidazo[1,2-a]pyrimidin-6-yl)pyridin-3-ol trifluoroacetate; 2-{6-[(3S,5R)-3,5-dimethylpiperazin-1-yl]pyridazin-3-yl}-5-(2-methylimidazo[1,2-a]pyrimidin-6-yl)pyridin-3-ol trifluoroacetate; 2-[6-(2,5-diazabicyclo[2.2.1]heptan-2-yl)pyridazin-3-yl]-5-(2-methylimidazo[1,2-a]pyrimidin-6-yl)pyridin-3-ol trifluoroacetate; 2-[6-(3-methylpiperazin-1-yl)pyridazin-3-yl]-5-[(pyridin-3-yl)amino]pyridin-3-ol dihydrochloride; 2-{6-[(3R,5S)-3,5-dimethylpiperazin-1-yl]pyridazin-3-yl}-5-[(E)-2-(1-methyl-1H-pyrazol-4-yl)ethenyl]pyridin-3-ol dihydrochloride; 2-{6-[(3S,5R)-3,5-dimethylpiperazin-1-yl]pyridazin-3-yl}-5-[(E)-2-(1-methyl-1H-pyrazol-4-yl)ethenyl]pyridin-3-ol dihydrochloride; 2-[6-(3-ethylpiperazin-1-yl)pyridazin-3-yl]-5-(1H-pyrazol-4-yl)pyridin-3-ol dihydrochloride; 2-[6-(3-ethylpiperazin-1-yl)pyridazin-3-yl]-5-(7-fluoro-2-methyl-2H-indazol-5-yl)pyridin-3-ol dihydrochloride; 2-{6-[(3S)-3-(propan-2-yl)piperazin-1-yl]pyridazin-3-yl}-5-(1H-pyrazol-4-yl)pyridin-3-ol dihydrochloride; 2-{6-[(3R)-3-(propan-2-yl)piperazin-1-yl]pyridazin-3-yl}-5-(1H-pyrazol-4-yl)pyridin-3-ol dihydrochloride; 5-(7-fluoro-2-methyl-2H-indazol-5-yl)-2-{6-[(3S)-3-(propan-2-yl)piperazin-1-yl]pyridazin-3-yl}pyridin-3-ol dihydrochloride; 2-[6-(3-cyclopropylpiperazin-1-yl)pyridazin-3-yl]-5-(1H-pyrazol-4-yl)pyridin-3-ol dihydrochloride; 2-{6-[(3R,5S)-3,5-dimethylpiperazin-1-yl]pyridazin-3-yl}-5-[(6-methylpyridin-3-yl)amino]pyridin-3-ol dihydrochloride; 2-{6-[(3R,5S)-3,5-dimethylpiperazin-1-yl]pyridazin-3-yl}-5-(1-methyl-1H-indazol-5-yl)pyridin-3-ol dihydrochloride; 2-{6-[(3S,5R)-3,5-dimethylpiperazin-1-yl]pyridazin-3-yl}-5-(1-methyl-1H-indazol-5-yl)pyridin-3-ol dihydrochloride; 5-[(6-methylpyridin-3-yl)amino]-2-{6-[(3R)-3-(propan-2-yl)piperazin-1-yl]pyridazin-3-yl}pyridin-3-ol dihydrochloride; 5-[(6-methylpyridin-3-yl)amino]-2-{6-[(3S)-3-(propan-2-yl)piperazin-1-yl]pyridazin-3-yl}pyridin-3-ol dihydrochloride; 2-{6-[(3S)-3-cyclopropylpiperazin-1-yl]pyridazin-3-yl}-5-(2H-1,2,3-triazol-2-yl)pyridin-3-ol dihydrochloride; 2-{6-[(3S)-3-cyclopropylpiperazin-1-yl]pyridazin-3-yl}-5-[1-( 2 H 3 ) methyl-1H-pyrazol-4-yl]pyridin-3-ol dihydrochloride; 2-{6-[3-(propan-2-yl)piperazin-1-yl]pyridazin-3-yl}-5-[(E)-2-(1H-pyrazol-4-yl)ethenyl]pyridin-3-ol dihydrochloride; 2-{6-[(3R,5S)-3,5-dimethylpiperazin-1-yl]pyridazin-3-yl}-5-(2H-indazol-5-yl)pyridin-3-ol dihydrochloride; 2-{6-[(3S,5R)-3,5-dimethylpiperazin-1-yl]pyridazin-3-yl}-5-(2H-indazol-5-yl)pyridin-3-ol dihydrochloride; 2-{6-[(3S)-3-ethylpiperazin-1-yl]pyridazin-3-yl}-5-(1H-pyrazol-4-yl)pyridin-3-ol dihydrochloride; 5-[(5-methylpyrazin-2-yl)amino]-2-{6-[(3R)-3-(propan-2-yl)piperazin-1-yl]pyridazin-3-yl}pyridin-3-ol dihydrochloride; 5-[(5-methylpyrazin-2-yl)amino]-2-{6-[(3S)-3-(propan-2-yl)piperazin-1-yl]pyridazin-3-yl}pyridin-3-ol dihydrochloride; 5-[(2-methylpyrimidin-5-yl)amino]-2-{6-[(3R)-3-(propan-2-yl)piperazin-1-yl]pyridazin-3-yl}pyridin-3-ol dihydrochloride; 5-[(2-methylpyrimidin-5-yl)amino]-2-{6-[(3S)-3-(propan-2-yl)piperazin-1-yl]pyridazin-3-yl}pyridin-3-ol dihydrochloride or a form thereof, wherein the salt form of said compound is selected from the group consisting of a hydrate, solvate, racemate, enantiomer, diastereoisomer, and tautomer form thereof.

13. 17. A pharmaceutical composition for treating or ameliorating Huntington's disease (HD) in a subject in need thereof, comprising a compound according to any one of claims 1, 9, or 10, or a form thereof.

14. The pharmaceutical composition of claim 13, wherein the compound is administered in the range of 0.001 mg / kg / day to 500 mg / kg / day.

15. 17. Use of a compound or a form thereof described in any one of claims 1, 9, or 10 in the manufacture of a medicament for treating or ameliorating Huntington's disease (HD) in a subject in need thereof, comprising administering to the subject an effective amount of the medicament.

16. The use according to claim 15, wherein the effective amount of the compound in the medicament ranges from 0.001 mg / kg / day to 500 mg / kg / day.

17. 11. Use of a compound or a form thereof described in any one of claims 1, 9 or 10 in the preparation of a pharmaceutical composition for treating or ameliorating Huntington's disease (HD) in a subject in need thereof, comprising administering to the subject an effective amount of the compound or a form thereof in admixture with one or more pharma- ceutical acceptable excipients.

18. The use according to claim 17, wherein the effective amount of the compound in the pharmaceutical composition ranges from 0.001 mg / kg / day to 500 mg / kg / day.

19. 11. A pharmaceutical composition comprising a compound or a form thereof according to any one of claims 1, 9 or 10 in admixture with one or more pharma- ceutically acceptable excipients.

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