Injection head of needleless syringe, needleless syringe body and needleless syringe

Abstract

To provide an injection head of a needleless syringe, a body of a needleless syringe and a needleless syringe. [Solution] The injection head of the needleless syringe 4 includes a liquid medicine tube 21 and a piston-equipped rod 22. The liquid medicine tube is open at its rear end and has an injection hole at its front end. The piston of the piston-equipped rod can move back and forth within the cavity, and together with the piston and the side and front walls of the liquid medicine tube, define a liquid medicine cavity 215, and a liquid medicine passage is provided within the piston-equipped rod. The injection head and medicine bottle 1 can be attached to the needleless syringe body together, and the liquid medicine can enter the liquid medicine cavity via the liquid medicine passage, and the piston-equipped rod can push the liquid medicine in the liquid medicine cavity and eject it outward via the injection hole.

Description

[Technical field]

[0001] The present invention relates to a medical device for injecting liquid medicine. More specifically, the present invention relates to a medical device for injecting liquid medicine. The present invention relates to an injection head for a needle injector, a needle-free injector and a needle-free injection assembly. [Background technology]

[0002] Needle-free syringes do not use needles and use high pressure on liquid medicines to deliver them to the patient. Therefore, since this is a medical device in which liquid medicine is injected subcutaneously through a small hole at the end, This allows the patient to avoid being pricked by a needle and feeling pain. Generally, needle-free syringes are and a push mechanism. The liquid medicine tube serves to contain a liquid medicine. Summary of the Invention

[0003] Generally, when using a needleless syringe, the first step is to attach the drug solution tube to the needleless syringe. Then, the needle tip of the medicine tube is used to suck up the medicine from the medicine bottle, After the medicine is drawn up, it cannot be injected unless the medicine tube and the medicine bottle are separated. As you can see, the process of obtaining medicines is relatively cumbersome.

[0004] To solve this problem, the current solution tube and the medicine bottle are integrated and used as disposable bottles. However, such solutions are expensive and require The materials of the chemical tubes / bottles are usually safe because they are in contact with chemicals for long periods of time. Not all requirements can be met.

[0005] Therefore, in order to solve at least some of the above problems, needleless syringes are being developed. A head, a body of a needle-free injector, and a needle-free injection assembly must be provided.

[0006] In order to overcome the above deficiencies, according to the present invention, an injection head of a needleless syringe, a needleless syringe According to the solution provided by the present invention, for example, a snap-on type The medicine bottle, which is a bottle of medicine, can be stored inside the needleless syringe, and after one use, the medicine can be inhaled and injected. This operation process can be completed efficiently and without hassle, and the whole process is done by using a medicine bottle. There is no need to take out the medicine bottle, and the medicine tube and the medicine bottle do not need to be separated. Containing the needle within the syringe avoids problems such as loss or contamination of the vial.

[0007] According to one aspect of the present invention, a needleless syringe is provided that can be used in combination with a reservoir bottle within the body of the needleless syringe. A needle-injector based injection head is provided, said injection head comprising: The nozzle has a cavity with an open rear end and a tip that connects the cavity to the outside. A drug solution tube having a micro-hole for injection formed therein; The drug solution tube is located within the cavity and can move back and forth within the cavity. a piston that can define a drug solution receiving cavity together with a side wall and a front wall of the piston; and a rod portion connected to said injection head, The rear end of the rod portion of the rod is insertable into the medicine bottle and is adapted to enter the medicine bottle. a piston extending from the piston rod and having a liquid medicine passage therein for connecting the liquid medicine cavity to the medicine storage bottle; and a rod attached thereto, The injection head and the medicine bottle can be attached to the body of the needleless syringe together, The rod with the piston is configured to allow the liquid medicine in the medicine storage bottle to flow through the liquid medicine passage into the liquid medicine receiving cavity. a liquid medicine tube that can move rearwardly relative to the liquid medicine tube so as to enter the liquid medicine receiving cavity; The drug solution is pushed through the injection hole to be injected outward. It is configured to be able to move forward relative to the

[0008] In one embodiment, the drug solution passage extends along the axial direction of the piston rod, At the tip of the piston rod, the liquid medicine enters the liquid medicine storage cavity from the medicine bottle. A check valve is installed that allows only

[0009] In one embodiment, the check valve is fitted within the piston, The valve core is movable back and forth by a small amount relative to the valve core, and the liquid medicine from the medicine bottle is always transferred to the valve core and the front The liquid flows through the gap between the piston and the drug solution and enters the drug solution containing cavity.

[0010] In one embodiment, the valve core is a spherical structure, or The valve core has a conical structure at the front and a cylindrical structure at the rear, a cylindrical structure having a diameter greater than or equal to the diameter of the cylindrical structure; larger than the diameter.

[0011] In one embodiment, the piston has an internal piston passage, Between the inner passage and the piston rod, there is a gap in the radial direction relative to the axis. The medicine from the medicine bottle necessarily flows through the passage in the piston and enters the medicine receiving cavity. do.

[0012] In one embodiment, the rear end of the rod portion is used to pierce the sealing membrane of the medicine bottle. It has a needle-tip-like structure.

[0013] In one embodiment, the injection head is adapted to close the injection hole. The drug solution tube further includes a cap portion removably positioned at the tip of the drug solution tube as shown in FIG.

[0014] In one embodiment, the piston rod is fixed relative to the reservoir bottle during use. or The piston rod also moves backward relative to the drug solution tube. to move rearwardly relative to the vial so as to compress the vial's storage space; The present invention is characterized in that it is configured as follows.

[0015] According to another aspect of the present invention, there is provided an injection head and a medicine bottle according to any one of the above solutions. and a needle-free syringe body for use in combination with the needle-free syringe, the needle-free syringe body comprising: A base having a forward-facing opening; The base has a rearward opening and is disposed between the base and the base to form a storage space. The front opening is provided so that the drug solution tube can be fixedly attached. Part case and A storage container is disposed in the storage space and has a forward opening, and the storage container is fixedly disposed therein. an internal plunger housed in the forward opening and having a piston-equipped rod secured to the forward opening; fruit, In order to realize the inhalation and injection of medicine, the outer case is connected to the medicine tube. The reservoir bottle and the piston rod are moved back and forth relative to the internal plunger. You can move forward and backward.

[0016] In one embodiment, the body of the needle-free syringe is connected between the base and the internal plunger. The device further includes a locking mechanism connected to the internal locking mechanism, the locking mechanism being adapted to lock the internal locking mechanism during the process of inhaling the medicine. The internal pusher can be locked to the base, and after the inhalation of the medicine is completed, the internal pusher can be locked to the base. The pusher is configured to be unlocked so as to move forward relative to the outer case. .

[0017] In one embodiment, the rear end of the internal pusher has a rear end protruding outward along a radial direction. A flange is provided, and the locking mechanism includes: The rear end flange is in a locked state so as to restrict the internal thruster from moving forward. A position limiting member configured to be able to abut against a tip surface of the A push button attached to a rear end wall of the base and protruding rearward relative to the base. and The push button moves forward relative to the base to directly or indirectly push the internal push button. The thrust force can be applied to the rear end surface of the child, The lock mechanism is adapted to release the lock of the internal pusher. The aft end flange is capable of overcoming the position limiting member under the action of the thrust force.

[0018] In one embodiment, the locking mechanism comprises: The inner pusher is disposed between the rear end surface of the inner pusher and the rear end wall of the push button, and the inner pusher is opened toward the rear. a spring receiving member having a spring receiving cavity; A push button spring is located in the spring receiving cavity and has a rear end capable of contacting the push button. a ring; and The push button is supported by the push button spring and the spring housing member. The inner thruster can be pushed to exert a thrust force on the inner thruster.

[0019] In one embodiment, the push button has a rear end wall and extends forward from the rear end wall. and a side wall surrounding the axis, and a tip of the side wall is provided with a needle that is oriented toward the axis of the body of the needleless syringe. The position limiting member is provided with a protruding portion protruding from the push button. The movable member is configured to be movable along a radial direction relative to the axis, In the locked state, the protrusion abuts against the radially outer side of the position limiting member. The position limiting member limits the radial outward movement of the pusher. When the button is pushed, the protrusion moves forward relative to the position limiting member. By this, the radial position restriction on the position limiting member is released, and at this time, The position limiting member is configured to move in a radial direction so as to release the lock on the internal pusher. and can move outwardly to release contact with the leading end surface of the rear flange.

[0020] In one embodiment, the position limiting member is a sphere, and the rear end surface of the protrusion and the The tip surfaces of the rear flanges are both sloped, so that the lock is released The position limiting member is capable of rolling contact with the inclined surface.

[0021] In one embodiment, the locking mechanism is an electromagnet.

[0022] In one embodiment, the body of the needle-free syringe is located between the base and the internal plunger. The method further includes a resilient actuation mechanism for storing energy prior to injection. After storing energy, the internal The plunger is configured to be actuated forward and released to complete the injection.

[0023] In one embodiment, a tip flap protruding outward along a radial direction is provided at the tip of the internal pusher. a distal flange is provided, and the elastic actuating mechanism is provided between the distal flange and the base. Includes an actuating spring.

[0024] In one embodiment, the actuation spring is arranged to surround the inner pusher. It is placed on the outside of the sushi.

[0025] In one embodiment, a spring shaft is fixedly connected to the tip flange of the internal pusher. The spring axis is parallel to the axis of the inner pusher, and the operating spring is It is provided so as to surround the spring shaft.

[0026] The spring shafts are multiple, and each spring shaft has one of the An actuating spring is provided, and each of the spring shafts is uniformly arranged around the inner pusher. It has been done.

[0027] In one embodiment, a center pusher is provided at a middle portion of the inner pusher along its circumferential direction. a middle flange is provided, and the elastic actuation mechanism is provided between the middle flange and the base Includes an actuating spring installed.

[0028] In one embodiment, the base includes a rear end and a base sidewall, the base sidewall having a female connector on an inner surface thereof. A male screw corresponding to the female screw is provided on the rear outer surface of the outer case. The female screw and the male screw are screwed together, and the outer case holds the operating spring. It can move rearwardly relative to the base for stable compression.

[0029] In one embodiment, the external device is configured to visually confirm the amount of liquid medicine in the medicine bottle from the outside. At least a part of the case and the internal plunger that corresponds to the medicine bottle in the radial direction is configured to be transparent or openwork.

[0030] According to another aspect of the present invention, there is provided a needleless syringe, the needleless syringe comprising: The body of the needle-free syringe according to any one of claims 1 to 5, which is used in combination with the body of the needle-free syringe. and an injection head.

[0031] In one embodiment, the needleless syringe is provided with a front opening of an outer case in the body of the needleless syringe. A female screw is provided in the needle syringe so as to face the axis of the needle syringe, and a male screw is provided in the drug solution tube of the injection head. The female screw and the male screw are screwed together to connect the drug solution tube to the needleless injection device. It can be detachably attached to the main body of the launcher.

[0032] According to yet another aspect of the present invention, there is provided a syringe for use in combination with an injection head and a vial. A needleless syringe body is provided, and the medicine bottle includes a bottle body having a medicine bottle receiving cavity; and a bottle stopper that can slide back and forth within the medicine bottle cavity relative to the body. The main body is A base having a forward-facing opening; The base has a rearward opening and is disposed between the base and the base to form a storage space. The front opening is provided so that the drug solution tube can be fixedly attached. Part case and an internal pusher located within the receiving space and having a forward opening; The medicine bottle is fixedly accommodated in the plunger, and a rod with a piston is fixed to the forward opening. An internal plunger system, A liquid refilling device is attached to the rear end of the internal plunger and has a tip capable of contacting the bottle cap of the medicine storage bottle. With a pusher, A part of the liquid medicine refilling plunger is connected to the liquid medicine refilling plunger, and another part of the liquid medicine refilling plunger is directly connected to the base or the outer case. or a transmission device to which the device can be indirectly connected; In order to realize the inhalation and injection of medicine, the outer case is connected to the medicine tube. The reservoir bottle and the piston rod are moved back and forth relative to the internal plunger. You can move forward and backward with During the process of inhaling the medicine, the base or the outer case is The liquid medicine refilling plunger is moved by the transmission device to the bottle body so as to compress the space between the bottle body and the liquid medicine refilling plunger. The bottle cap of the medicine bottle is pushed forward against the

[0033] In one embodiment, the body of the needle-free syringe includes the base and the internal plunger system. and a locking mechanism connected between the locking mechanism and the inhalation device, the locking mechanism being adapted to lock the locking mechanism during the process of inhaling the medicine. The internal pusher system can be locked to the base in the forward and backward directions, and the medicine can be sucked in. After insertion is completed, the inner pusher system moves forward relative to the outer case. It is configured so that the lock can be released.

[0034] In one embodiment, the base and the outer case are rotatably joined to each other, The relative rotation of the outer case and the base causes the needleless syringe body to rotate in the axial direction. The outer case and the base are movable relative to each other.

[0035] In one embodiment, the internal thruster system further comprises a transmission rod, a front end connected to the transmission device and a rear end used for connecting to the lock mechanism; When the transmission rod is locked by the lock mechanism, the transmission rod is also in the rotation direction. Fixed to a pedestal.

[0036] In one embodiment, the transmission device includes a rotary motion transmission device, The device rotates the liquid refilling plunger by rotating the liquid refilling plunger. It is configured to be able to transmit the liquid medicine refilling pusher, A motion conversion mechanism is installed in the body of the needleless syringe, and the medicine is transferred to the transmission rod. The rotational movement of the liquid refill plunger relative to the internal plunger along the axial direction of the body of the needleless syringe. A part of the motion conversion mechanism is joined to the drug solution refilling plunger so as to convert the motion into a linear motion. Another part of the motion conversion mechanism is directly or indirectly joined to the internal pusher.

[0037] In one embodiment, the outer case rotates relative to the base during the process of inhaling the medicine. By rotating, it moves forward relative to the base, The rotary motion transmission device includes a one-way rotary motion transmission device, The outer case is rotated relative to the base, and the outer case moves forward relative to the base. During the movement, the rotational motion of the transmission rod can be transmitted to the drug refilling plunger. In the process in which the main case rotates relative to the base and moves backward relative to the base, The rotational motion of the transmission rod cannot be transmitted to the liquid refilling plunger.

[0038] In one embodiment, the one-way rotational motion transmission device includes a one-way bearing, The outer ring of the bearing is fixedly connected to the transmission rod, and the inner ring of the one-way bearing and the liquid refilling plunger is connected so as to be fixed in the rotational direction about the axis of the body of the needle-free syringe.

[0039] The motion conversion mechanism is disposed in the accommodating space of the internal pusher and is configured to The liquid refilling pusher includes a nut member fixedly connected to the liquid refilling pusher, and the liquid refilling pusher is connected to the front end of the liquid refilling pusher in the form of a screw thread. The nut member is joined to the above nut member.

[0040] In one embodiment, the nut member comprises at least two nut members spaced apart from each other. The at least two nut members are arranged to surround the liquid refilling plunger. The nut member is adapted to be joined to or separated from the chemical solution refilling plunger. Moves toward or away from the axis of the body of the needle-free syringe along the radial direction of the body of the needle-free syringe It is possible.

[0041] In one embodiment, the at least two nut members are A force is applied to the nut member along the axial direction of the body of the needle-free syringe, and the force When the predetermined threshold value is reached, the at least two nut members move along the radial direction. The liquid supply plunger is then moved in a direction away from the axis and released from its connection with the liquid supply refill plunger.

[0042] In one embodiment, the circumferential outer surface of the nut member and the circumferential inner surface of the internal pusher An elastic member is installed between the two nuts and the chemical solution refilling plunger, and the connection between the two nuts and the chemical solution refilling plunger is released. As a result, the elastic member is compressed.

[0043] In one embodiment, the body of the needleless syringe is installed at the tip of each of the nut members. The nut position limiting member is further provided. The surface that comes into contact with the position limiting member is a force receiving slope, and the rear end of the force receiving slope is The nut position limiting member is located radially away from the axis of the needleless syringe from the tip. The force receiving member is arranged to press the nut member until it is joined with the chemical solution refilling pusher. The nut position limiting member is configured to be able to push the slope backward. When the application of force to the members is stopped, the nut members are separated from each other along the radial direction. On the other hand, it is configured to be released from the connection with the drug solution refilling plunger.

[0044] In one embodiment, when the medicine bottle is attached to the internal plunger, The nut member can be continuously pressed by the force in the direction of the medicine bottle. After the nut position limiting member is removed from the internal pusher, The tip of the nut position limiting member is fixed to the medicine bottle so as to stop the application of force to the bar. It is possible to directly contact the rear end of the bottle body.

[0045] In one embodiment, the nut position limiting member is a wedge block, The cam has a force application inclined surface that contacts the force receiving inclined surface.

[0046] In one embodiment, the nut position limiting member is a spherical structure, and the nut A spherical motion groove is provided at the tip position of the radial outer edge of the member, and the nut position limiting member is confined within the spherical motion groove and cannot escape therefrom.

[0047] In one embodiment, the nut position limiting member has an axis aligned with the body of the needleless syringe. a common annular structure, the annular structure being cut in a plane along which the axis of the annular structure lies; The cross section is circular.

[0048] A rear end flange protruding outward along a radial direction is provided at the rear end of the internal thruster system. The locking mechanism is provided The rear thruster system is locked in a locked state to restrict the internal thruster system from moving forward. A position limiting member configured to be able to abut against a tip surface of the end flange; A push button attached to a rear end wall of the base and protruding rearward relative to the base. and The push button moves forward relative to the base to directly or indirectly push the internal push button. The thrust force can be applied to the rear end surface of the child, The lock mechanism is adapted to release the lock of the internal pusher. The aft end flange is capable of overcoming the position limiting member under the action of the thrust force.

[0049] In one embodiment, the locking mechanism comprises: A push button is provided between the rear end surface of the internal pusher system and the rear end wall of the push button. a spring receiving member having an open spring receiving cavity; A push button spring is located in the spring receiving cavity and has a rear end capable of contacting the push button. a ring; and The push button is supported by the push button spring and the spring housing member. The internal thruster system can be pushed to exert a thrust thereon.

[0050] In one embodiment, the push button has a rear end wall and extends forward from the rear end wall. and a side wall surrounding the axis, and a tip of the side wall is provided with a needle that is oriented toward the axis of the body of the needleless syringe. The position limiting member is provided with a protruding portion protruding from the push button. The movable member is configured to be movable along a radial direction relative to the axis, In the locked state, the protrusion abuts against the radially outer side of the position limiting member. The position limiting member limits the radial outward movement of the pusher. When the button is pushed, the protrusion moves forward relative to the position limiting member. By this, the radial position restriction on the position limiting member is released, and at this time, The position limiting member is adapted to be radially displaced so as to release the lock on the internal pusher system. The rear flange can be moved outward along the axis of the rear end of the bearing to release contact with the leading end surface of the rear end flange.

[0051] In one embodiment, the position limiting member is a sphere, and the rear end surface of the protrusion and the The tip surfaces of the rear flanges are both sloped, so that the lock is released The position limiting member is capable of rolling contact with the inclined surface.

[0052] In one embodiment, the locking mechanism is an electromagnet.

[0053] In one embodiment, the body of the needle-free syringe includes the base and the internal plunger system. and a resilient actuation mechanism disposed between the energy It is operated to store energy, and after storing energy, it is released by elastic force. The internal pusher system can be actuated forward and released to complete the injection. do.

[0054] In one embodiment, a tip flap protruding outward along a radial direction is provided at the tip of the internal pusher. a distal flange is provided, and the elastic actuating mechanism is provided between the distal flange and the base. Includes an actuating spring.

[0055] In one embodiment, the actuation spring is arranged to surround the inner pusher. It is placed on the outside of the sushi.

[0056] A spring shaft is fixedly connected to the tip flange of the internal pusher. The axis of the inner thruster is parallel to the axis of the inner thruster, and the operating spring surrounds the spring axis. It will be set up like this.

[0057] In one embodiment, the spring shaft is a plurality of spring shafts, and each spring shaft has: Each of the springs is connected to the inner pusher. are arranged around the

[0058] In one embodiment, a center pusher is provided at a middle portion of the inner pusher along its circumferential direction. a middle flange is provided, and the elastic actuation mechanism is provided between the middle flange and the base Includes an actuating spring installed.

[0059] In one embodiment, the base includes a rear end and a base sidewall, the base sidewall having a female connector on an inner surface thereof. A male screw corresponding to the female screw is provided on the rear outer surface of the outer case. The female screw and the male screw are screwed together, and the outer case holds the operating spring. It can move rearwardly relative to the base for stable compression.

[0060] In one embodiment, the external device is configured to visually confirm the amount of liquid medicine in the medicine bottle from the outside. At least a part of the case and the internal plunger that corresponds to the medicine bottle in the radial direction is configured to be transparent or openwork.

[0061] In one embodiment, an inner pusher protruding outward along a radial direction is provided on the outer periphery of the inner pusher. A push flange is provided, and a circumferential outer surface of the inner push flange and a circumferential outer surface of the outer case are The inner circumferential surface of the inner pusher flange and the inner circumferential surface of the outer case are in contact with each other. A motion limiting structure is provided on the outer case. The motion limiting structure is configured such that the inner pusher is connected to the outer case. However, the inner pusher can be prevented from rotating forward and backward relative to the outer case. The present invention is configured to allow the movement of the yaw rate in the y direction.

[0062] In one embodiment, the motion limiting structure is in contact with a circumferential outer surface of the inner pusher flange. A key is formed on the circumferential inner surface of the inner housing and extends in the axial direction of the body of the needleless syringe. Includes grooves or guide bars.

[0063] According to another aspect of the present invention, there is provided a needleless injector, the needleless injector comprising any one of the above solutions. The body of the needle-free syringe according to any one of claims 1 to 4, which is used in combination with the body of the needle-free syringe. and an injection head.

[0064] In one embodiment, the injection head is used in combination with a reservoir bottle, teeth, The nozzle has a cavity with an open rear end and a tip that connects the cavity to the outside. A drug solution tube having a micro-hole for injection formed therein; The drug solution tube is located within the cavity and can move back and forth within the cavity. a piston that can define a drug solution receiving cavity together with a side wall and a front wall of the piston; and a rod portion connected to said injection head, The rear end of the rod portion of the rod is insertable into the medicine bottle and is adapted to enter the medicine bottle. a piston extending from the piston rod and having a liquid medicine passage therein for connecting the liquid medicine cavity to the medicine storage bottle; and a rod attached thereto, The injection head and the medicine bottle can be attached to the body of the needleless syringe together, The rod with the piston is configured to allow the liquid medicine in the medicine storage bottle to flow through the liquid medicine passage into the liquid medicine receiving cavity. a liquid medicine tube that can move rearwardly relative to the liquid medicine tube so as to enter the liquid medicine receiving cavity; The drug solution is pushed through the injection hole to be injected outward. It is configured to be able to move forward relative to the

[0065] In one embodiment, the drug solution passage extends along the axial direction of the piston rod, At the tip of the piston rod, the liquid medicine enters the liquid medicine storage cavity from the medicine bottle. A check valve is installed that allows only

[0066] In one embodiment, the check valve is fitted within the piston, The valve core is movable back and forth by a small amount relative to the valve core, and the liquid medicine from the medicine bottle is always transferred to the valve core and the front The liquid flows through the gap between the piston and the drug solution and enters the drug solution containing cavity.

[0067] In one embodiment, the valve core is a spherical structure, or The valve core has a conical structure at the front and a cylindrical structure at the rear, a cylindrical structure having a diameter smaller than that of the cylindrical structure; larger than the diameter.

[0068] In one embodiment, the piston includes a piston member extending in a direction parallel to the axial direction. A piston passage is provided between the piston passage and the piston rod. There is a gap in the radial direction relative to the axis, and the medicine from the medicine bottle always flows into the pipe. The liquid flows through the passage in the stone and enters the drug solution containing cavity.

[0069] In one embodiment, the rear end of the rod portion is used to pierce the sealing membrane of the medicine bottle. It has a needle-tip-like structure.

[0070] In one embodiment, the injection head is adapted to close the injection hole. The drug solution tube further includes a cap portion removably positioned at the tip of the drug solution tube.

[0071] In one embodiment, the needleless syringe is provided with a front opening of an outer case in the body of the needleless syringe. A female screw is provided in the needle syringe so as to face the axis of the needle syringe, and a male screw is provided in the drug solution tube of the injection head. The female screw and the male screw are screwed together to connect the drug solution tube to the needleless injection device. It can be detachably attached to the main body of the launcher.

[0072] According to the present invention, a medicine bottle, for example a snap-on bottle, can be used as a needleless syringe for a long period of time. It can be stored in the body and used once to complete the inhalation and injection of medicine, and this operation process It is efficient and hassle-free, and there is no need to take out the medicine bottle during the entire process. The liquid tube and the medicine bottle do not need to be separated. In addition, the medicine bottle can be housed inside the needleless syringe. This can avoid problems such as loss or contamination of the medicine bottle.

[0073] The above objects, features, advantages and functions of the present invention, as well as others, are easily understood. For this purpose, reference may be made to the preferred embodiments illustrated in the drawings, in which: Those skilled in the art will appreciate that the drawings are illustrative of preferred embodiments of the present invention. The above description is used to explain the form of the invention in a schematic manner and does not limit the scope of the invention in any way. It should be understood that the drawings are not to scale and that the components in the drawings are not to scale. do. [Brief description of the drawings]

[0074] [Figure 1] FIG. 1 is an exploded cross-sectional view of an injection head of a needleless injector according to one preferred embodiment of the present invention. [Diagram 2] FIG. 2 is a cross-sectional view of the injection head and the medicine bottle in FIG. 1 in a connected state. [Diagram 3] FIG. 3 is a cross-sectional view of the injection head in FIG. 2 during the process of inhaling medicine. [Figure 4] 4 is a cross-sectional view of the injection process of the injection head in FIG. 2. FIG. [Diagram 5] 5 and 6 are cross-sectional views of the tip of the injection head in FIG. 2 in a preliminary state and in a state of inhaling medicine, respectively. [Figure 6] 5 and 6 are cross-sectional views of the tip of the injection head in FIG. 2 in a preliminary state and in a state of inhaling medicine, respectively. [Figure 7] 7-8 are cross-sectional views of an alternative to FIGS. 5-6. [Figure 8] 7-8 are cross-sectional views of an alternative to FIGS. 5-6. [Figure 9] 9-10 are cross-sectional views of another alternative to FIGS. 5-6. [Figure 10] 9-10 are cross-sectional views of another alternative to FIGS. 5-6. [Figure 11] FIG. 11 is a cross-sectional view of the body of a needle-free syringe according to one preferred embodiment of the present invention. [Figure 12] FIG. 12 is a cross-sectional view of the rear part of the needle-free syringe in FIG. 11, in which the locking mechanism is in a locked state. [Figure 13] FIG. 13 is another cross-sectional view of the rear part of the needle-free syringe in FIG. 11, in which the locking mechanism is in an unlocked state. [Figure 14] 14 to 19 are cross-sectional views showing the process of mounting an injection head and a medicine bottle onto the body of a needle-free syringe, and the process of inhaling medicine and performing needle-free injection using the needle-free syringe. [Figure 15] 14 to 19 are cross-sectional views showing the process of mounting an injection head and a medicine bottle onto the body of a needle-free syringe, and the process of inhaling medicine and performing needle-free injection using the needle-free syringe. [Figure 16] 14 to 19 are cross-sectional views showing the process of mounting an injection head and a medicine bottle onto the body of a needle-free syringe, and the process of inhaling medicine and performing needle-free injection using the needle-free syringe. [Figure 17] 14 to 19 are cross-sectional views showing the process of mounting an injection head and a medicine bottle onto the body of a needle-free syringe, and the process of inhaling medicine and performing needle-free injection using the needle-free syringe. [Figure 18] 14 to 19 are cross-sectional views showing the process of mounting an injection head and a medicine bottle onto the body of a needle-free syringe, and the process of inhaling medicine and performing needle-free injection using the needle-free syringe. [Figure 19] 14 to 19 are cross-sectional views showing the process of mounting an injection head and a medicine bottle onto the body of a needle-free syringe, and the process of inhaling medicine and performing needle-free injection using the needle-free syringe. [Figure 20] FIG. 20 is a cross-sectional view of an alternative to the needle-free syringe of FIGS. 14-19. [Figure 21] FIG. 21 is a cross-sectional view of another alternative to the needle-free syringe of FIGS. [Figure 22] 22-28 are cross-sectional views of another preferred embodiment showing the process of attaching an injection head and a medicine bottle to the body of a needle-free syringe and using the needle-free syringe to inhale and inject medicine without needles. [Figure 23] 22-28 are cross-sectional views of another preferred embodiment showing the process of attaching an injection head and a medicine bottle to the body of a needle-free syringe and using the needle-free syringe to inhale and inject medicine without needles. [Figure 24]22-28 are cross-sectional views of another preferred embodiment showing the process of attaching an injection head and a medicine bottle to the body of a needle-free syringe and using the needle-free syringe to inhale and inject medicine without needles. [Diagram 25] 22-28 are cross-sectional views of another preferred embodiment showing the process of attaching an injection head and a medicine bottle to the body of a needle-free syringe and using the needle-free syringe to inhale and inject medicine without needles. [Figure 26] 22-28 are cross-sectional views of another preferred embodiment showing the process of attaching an injection head and a medicine bottle to the body of a needle-free syringe and using the needle-free syringe to inhale and inject medicine without needles. [Figure 27] 22-28 are cross-sectional views of another preferred embodiment showing the process of attaching an injection head and a medicine bottle to the body of a needle-free syringe and using the needle-free syringe to inhale and inject medicine without needles. [Figure 28] 22-28 are cross-sectional views of another preferred embodiment showing the process of attaching an injection head and a medicine bottle to the body of a needle-free syringe and using the needle-free syringe to inhale and inject medicine without needles. [Figure 29] FIG. 29 is a cross-sectional view of the body of the needle-free syringe in FIGS. 22-28 after completing a needle-free injection. [Figure 30A] FIG. 30A is a schematic cross-sectional view of an assembled state of members such as the internal pusher system, the nut member, and the one-way bearing in FIGS. 22-28. FIG. [Figure 30B] FIG. 30B is a schematic diagram taken along line AA in FIG. 30A. [Diagram 31] FIG. 31 is a schematic cross-sectional view of an assembled state of components such as an internal thruster system, a nut member and a one-way bearing in one alternative embodiment of the configurations of FIGS. 22-28. [Figure 32A] FIG. 32A is a schematic diagram of the nut member and the liquid refilling plunger of each member in FIG. 31 in a joined state. [Figure 32B]FIG. 32B is a schematic diagram of the nut member and the liquid refilling plunger of each member in FIG. 31 in a detached state. [Figure 33A] 33A-33B are schematic diagrams of an alternative to FIGS. 32A-32B. [Figure 33B] 33A-33B are schematic diagrams of an alternative to FIGS. 32A-32B. [Figure 34A] 34A-34B are schematic diagrams of another alternative to FIGS. 32A-32B. [Figure 34B] 34A-34B are schematic diagrams of another alternative to FIGS. 32A-32B. DETAILED DESCRIPTION OF THE PREFERRED EMBODIMENTS

[0075] Now, with reference to the drawings, the needleless syringe, the body of the needleless syringe and the needleless injection device according to the present invention will be described. The injection head of the injector will be described in detail. The following is a preferred embodiment of the present invention. It is understood that those skilled in the art may realize other forms of implementing the present invention based on the above-described preferred embodiments. and other configurations as described above are within the scope of the present invention as well.

[0076] The present invention provides an injection head of a needle-free syringe, a body of a needle-free syringe and a needle-free syringe. - Figure 34B shows some preferred embodiments according to the invention.

[0077] First, it is necessary to explain that the "axial direction" described in this specification is the axis X of the needleless syringe. In this axial direction, the needleless syringe is inserted into the patient when the needleless syringe is used. The direction toward is referred to as the "front side" and the opposite direction is referred to as the "rear side." The "radial direction" described here is the radial direction relative to the axial direction, and the radial direction is indicated by X' in FIG. As shown.

[0078] FIG. 1 is an exploded schematic view of one preferred embodiment of an injection head 2 of a needleless syringe. The injection head 2 is used in combination with the medicine bottle 1, and the medicine bottle 1 is, for example, a standard based on a national standard. 2 to 4 show schematic diagrams of the connection between the injection head 2 and the medicine bottle 1. When the injection head 2 and the medicine bottle 1 are correctly connected, they are put together into the body 3 of the needleless syringe (see FIG. 11). ) was attached.

[0079] As shown in FIGS. 1 to 4, the injection head 2 has a substantially rotationally symmetrical structure about an axis X. Specifically, the liquid medicine tube 21 and the rod 22 with the piston are included. The inside of the tube 21 has a cavity with an open rear end, and the tip of the tube 21 is provided with An injection hole 211 is formed to communicate the cavity with the outside. The piston 221 includes a rod portion 222, and the piston 221 is positioned in the cavity. The piston 221 can move back and forth within the cavity, and moves together with the side and front walls of the drug solution tube 21. A drug solution receiving cavity 215 can be defined in the piston 221, and the rod portion 222 is fixedly connected to the rear end of the piston 221. The rod 22 with the piston extends until it enters the medicine storage bottle 1. A liquid medicine passage 222c is provided to connect the cavity 215 and the medicine bottle 1. It preferably extends along an axis X.

[0080] The rear end of the rod portion 222 is provided with a needle tip structure 22 for piercing the sealing membrane at the tip of the medicine bottle 1. 2b. The injection head 2 is used to close the injection hole 211. The liquid medicine tube further includes a cap portion 23 removably positioned at the tip of the liquid medicine tube 21 so as to It is also preferable that the cap portion 23 has a cap portion protrusion 231. A liquid tube groove 214 may be provided in the liquid tube, and the cap portion 23 may be disposed on the liquid tube. The cap portion protrusion 231 and the drug solution tube recess 214 are aligned with each other so that the drug solution tube can be easily attached to the tube 21. In another embodiment not shown, the cap portion 23 is not provided separately. Alternatively, the drug solution tube 21 may be installed so that the injection hole 211 itself can be opened and closed.

[0081] 3, when the cap portion 23 is attached to the tip of the drug solution tube 21, The tapped rod 22 moves backward relative to the drug solution tube 21, and at this time, the drug solution receiving cavity 215 As a result of the negative pressure being generated within the medicine storage bottle 1, the medicine liquid in the medicine storage bottle 1 flows through the medicine liquid passage 222c. The medicine can be sucked into the receiving cavity 215. The rear end of the medicine storage space of the medicine storage bottle 1 is closed by a movable bottle stopper 12. The bottle stopper 12 is configured so as to be freely movable relative to the bottle body 11 under the action of gas pressure. In other words, during the process of inhaling the medicine, the bottle stopper 12 is preferably The medicine can be inhaled easily because it can move forward with respect to the bottle body 11 to ensure that the medicine does not get stuck. During the entire process, the rate of drug inhalation is relatively stable. After the intake of the drug is completed, the cap portion 23 is removed and the piston rod 22 is inserted into the drug reservoir. By controlling the forward movement of the liquid tube 21, the liquid medicine receiving cavity 215 The liquid medicine can be injected through the injection hole 211.

[0082] During the process of inhalation and injection of medicine, the liquid medicine flows back from the liquid medicine receiving cavity 215 to the medicine bottle 1. In order to prevent contamination by the liquid, a check valve is provided at the end of the piston rod 22. The check valve may be configured to allow the liquid medicine to enter only the liquid medicine receiving cavity 215 from the medicine bottle 1. 5 to 10 show three specific embodiments of the check valve. It is being done.

[0083] The two check valves shown in FIGS. 5 to 8 are fitted into the piston 221. The valve core includes a valve member that can move back and forth with a small amount relative to the piston 221. The valve is formed in a rotationally symmetrical structure, and the liquid medicine from the medicine bottle 1 flows through the gap between the valve core and the piston 221. Of course, in other embodiments not shown, the valve The core may have an asymmetric structure. Specifically, in this embodiment, during the process of inhaling the medicine, Since negative pressure exists at the valve, the piston 221 is distorted, and the valve core is pulled by the suction force. 221, it also moves slightly forward to form a passage between the valve core and the piston 221. When the inhalation of the medicine is completed, the movement of the piston rod 22 stops. The liquid medicine is replenished through the passage into the cavity, and the negative pressure disappears. After the tube 21 is removed, the tip of the tube 21 has a small hole 211, so the When the internal pressure of the cavity becomes equal to the external pressure, the valve core is pushed back to its original position. This prevents backflow of the drug solution.

[0084] Specifically, in one embodiment shown in FIG. 5 and FIG. 6, the check valve is a spherical valve, The core 223 is a sphere, and the piston 221 is provided with a receiving structure that fits the outer contour of the sphere. FIG. 5 is a schematic diagram of the state where the liquid medicine does not flow through the valve core 223, and FIG. 6 is a schematic diagram of the liquid medicine flowing through the valve core 223. As shown in FIG. 222c, reaches the valve core 223, and flows through the gap between the valve core 223 and the piston 221. The liquid passes through the valve core 223 and enters the medicinal solution containing cavity 215 (that is, bypasses the valve core 223 ).

[0085] In one embodiment shown in FIGS. 7 and 8, the check valve core 224 has front and rear It includes two parts, a front part being a cone-shaped structure 224a and a rear part being a cylindrical structure 224b. , the cylindrical structure 224b is connected to the bottom surface of the conical structure 224a, and the conical structure 224a The diameter of the bottom surface of the piston 221′ is larger than the diameter of the cylindrical structure 224b. 21b exactly matches the rear end surface of the cone-shaped structure 224a, and the valve core 224 is inserted into the piston 221 When the valve core 224 and the piston 221' are attached to the valve seat 222, the tip of the entire structure of the valve core 224 and the piston 221' forms a single cone shape. It is preferable to form the structure just above the valve core 224, and the valve core 224 is made of an elastic material. During the inhalation process, the negative pressure in the cavity containing the drug solution (in addition to this, the impact force of the drug solution) The tip of the cone-shaped structure 224 is subjected to a forward suction force by the force of the cylindrical portion 2 The rear end of 24b is provided with a small protrusion 224c that engages with the piston 221'. However, since the rear end is fixed to the piston 221', the valve core 224 is elastically deformed to some extent, and the conical portion 224a of the valve core 224 is moved toward the piston 221'. By moving slightly forward, the cone portion 224a of the valve core 224 and the piston 221' A gap will appear between the two, and the liquid medicine will inevitably flow through the gap and enter the liquid medicine receiving cavity 215. .

[0086] 9 and 10 show another embodiment of the check valve structure. The check valve does not have a valve core, and the piston 221 has an inner piston passage 221c. The piston passage 221c may be parallel to the axial direction or may be spaced apart from the axial direction. In addition, the piston passage 221c and the piston rod 22 may have a certain angle. There is a gap between them in the radial direction relative to the axis. First, the drug solution passage 222c in the rod portion 222 and the piston passage 221 in the piston 221″ are After flowing through 1c, it enters the medicinal solution containing cavity 215.

[0087] In the embodiment shown in the drawings, the piston rod 22 is adapted for both inhalation and injection of the drug. In the operation of the above, the medicine bottle 1 is fixed, and in the process of inhaling the medicine, the medicine liquid receiving cavity 21 The medicinal liquid is drawn from the medicine bottle 1 into the medicine liquid receiving cavity 215 only by the pressure difference between the pressure sensor 5 and the inside of the medicine bottle 1. However, in another embodiment not shown, the piston rod 22 The rear end of the vial may be provided with a movable piston, which is movable in the medicine bottle during the inhalation process. Thus, not only does the piston rod 22 move backward relative to the liquid tube 21, but at the same time By moving backward with respect to the medicine bottle 1, the piston in the medicine bottle This compresses the space between the capsule and the inhaler, and this operation can further improve the speed at which the medicine is inhaled.

[0088] FIG. 11 shows a needleless syringe for use in combination with the injection head 2 and the medicine bottle 1. One preferred embodiment of the body 3 is shown. As shown in FIG. The body 3 includes a base 31, an outer case 32, and an inner pusher 33. The base 31 faces forward. The outer case 32 has a rearward opening and is connected to the base 31 and the outer case 32. The housing 31 is attached to the tip of the base 31 so as to form a storage space between the base 31 and the outer case 32. The front opening is provided for fixedly mounting the drug solution tube 21. The internal plunger 33 is The medicine bottle 1 is accommodated in the internal plunger 33. The piston rod 22 can move together with the internal pusher 33 and is inserted into the forward opening. It is fixedly attached.

[0089] The connection relationship of each of the above members has multiple options. For example, The connection between the tube 21 and the liquid medicine may be made by a screw thread. A male screw 213 for the drug solution tube is provided on the outer surface of the rear part of the tube 21, and the outer case 32 The female screw 322a of the housing is provided at the front opening of the housing, and the male screw 213 of the drug solution tube is The female thread 322a of the housing can be screwed into the drug solution tube 21 and the outer case The drug solution tube 21 is just engaged with the tip surface of the outer case 32. A position limiting flange 212 may be provided to ensure that the

[0090] The cooperation between the piston rod 22 and the inner plunger 33 may be a snap-type cooperation. Specifically, as shown in FIG. 14, a snap is provided on the outer surface of the piston rod 22. A snap-type protrusion 222d is provided at the corresponding position of the internal pusher 33, and a snap-type recess 33a is provided at the corresponding position of the internal pusher 33. The piston is then set in place, and the snap-fit ​​protrusion 222d engages in the recess 33a, thereby The piston rod 22 is fixed to the internal plunger 33. The rear part 222a of the piston rod 22 may have a large radial dimension to match the internal plunger 33. The space inside the plunger 33 may be provided with a space of a size suitable for the medicine bottle 1, and the piston After the rod 22 and the internal plunger 33 are snapped together, the medicine bottle 1 is The medicine bottle 1 is adaptively placed in the space, and the medicine bottle 1 is placed against the internal plunger 33 in the space. There is no space to allow movement.

[0091] In this way, the outer case 32 is always in the medicine tube during the entire process of inhaling and injecting medicine. The internal plunger 33 is always in contact with the medicine bottle 1 and the rod 22 with the piston. However, there is always a gap between the outer case 32, the inner pusher 33, and the base 31. Therefore, the outer case 32 can move with the drug solution tube 21, and the inner case 32 can move with the drug solution tube 21. The plunger 33 can move together with the medicine bottle 1 and the piston 221.

[0092] Specifically, in order to realize the inhalation and injection of medicine, the outer case 32 is provided with the medicine tube 21. The internal plunger 3 is moved back and forth relative to the medicine bottle 1 and the piston rod 22. 3. More specifically, during the process of inhaling medicine (see FIG. 17), The internal pusher 33 is fixed to the base 31, and the external case 32 is fixed to the internal pusher 33. During the injection process (see FIG. 19), the outer case 32 is moved forward relative to the base 31. The inner pusher 33 is fixed to the outer case 32, and moves forward relative to the outer case 32. The process of inhaling and injecting effective medications will be explained in detail later.

[0093] The main body 3 of the needleless syringe further includes a locking mechanism 34. The locking mechanism 34 is connected to the base 31. The inner plunger 33 is connected to the base 31 during the inhalation process of the medicine. After the inhalation of the medicine is completed, the internal plunger 33 is locked in the external case. Preferably, the lock can be unlocked so that it can move forward relative to 32.

[0094] 12 and 13 show one preferred embodiment of the locking mechanism 34. The state shown in FIG. 12 is when the lock mechanism 34 is locked. The state shown in FIG. 16 is the state where the lock is already released, and the state shown in FIG. FIG. 19 shows the cooperation between the internal pusher 33 and the locking mechanism 34.

[0095] A rear end flange 333 is provided at the rear end of the internal plunger 33, protruding outward along the radial direction. 16, and the rear end flange 333 is used to cooperate with the lock mechanism 34. 2. As shown in FIG. 13 and FIG. 16, the lock mechanism 34 includes a position limiting member 344 and , a push button 341, a spring accommodating member 342, and a push button spring 343. The position limiting member 344 is configured to limit the forward movement of the internal pusher 33. In the locked state, the push button 341 can abut against the tip surface 333a of the rear end flange 333. , which is attached to the rear end wall of the base 31 and protrudes rearward from the base 31, The housing member 342 is disposed between the rear end surface of the internal pusher 33 and the rear end wall of the push button 341. The push button spring 343 is provided with a spring receiving cavity that opens to the rear. It is located within the spring accommodating cavity, and its rear end is capable of contacting the push button 341.

[0096] In this manner, the push button 341 includes a push button spring 343 and a spring housing member 342 is pushed to indirectly push the internal pusher 33 As a result, the rear end flange 333 of the internal plunger 33 is in contact with the internal plunger 33. The position limiting member 344 can be exceeded so that the locking mechanism 34 is unlocked. In another embodiment, the push button spring 343 and the spring receiving member 3 42 and other members are not required, and the push button 341 directly pushes the internal pusher 33. By pressing the locking mechanism 34, the locking mechanism 34 is released from the internal pusher 33.

[0097] As also shown in FIG. 12 to FIG. 19, the push button 341 has a rear end wall and a front end wall extending from the rear end wall. and a side wall 341b extending in the direction of the axis X and surrounding the axis X. A protruding portion 341c is provided that protrudes toward the axis of the main body 3 of the shooter, and a position limiting mechanism is provided. The member 344 can move along a radial direction with respect to the axis of the push button 341. In the locked state shown in FIG. 12 and FIG. 16 to FIG. 18, the protruding portion 341c When the position limiting member 344 abuts against the radially outer side of the position limiting member 344, the position limiting member 344 limits the radial outward movement of the position limiting member 344. The position limiting member 344 locks the inner pusher 33 so that it cannot move radially outward. In this way, the inner plunger 33 can stably abut against the tip surface 333a of the rear end flange 333 of the inner plunger 33. When the push button 341 is pushed, the protruding portion 341c contacts the position limiting member 344. By moving forward, the radial position restriction on the position limiting member 344 is released. The position limiting member 344 is slid to the inner pusher 33 to release the lock. 3. The inner plunger 33 moves outward along the direction of the arrow 33a to release the contact with the tip surface of the rear end flange 333 of the inner plunger 33. 13 and 19 show the state after the locking mechanism 34 has been unlocked.

[0098] The position limiting member 344 is a sphere that is installed symmetrically with respect to the axis line, and the protruding portion 341 12 and the front end surface 333 of the rear end flange 333 of the internal plunger 33. a (see FIG. 11) are both inclined surfaces, so that the position It is more preferable that the limiting member 344 be capable of rolling contact with the slope, thereby making it easier to use. A person can release the lock by applying a small force to the push button 341.

[0099] In other embodiments not shown, other locking mechanisms 34 may be provided. For example, the lock mechanism 34 may be an electromagnet. When installed in the body 3, the electromagnet may be energized to lock the internal plunger 33, After this, the medicine is inhaled. After the medicine is inhaled, the electromagnet is turned off and the magnetism of the electromagnet is eliminated. At this time, the inner plunger 33 may be pushed against the outer case 32 to complete the injection. and move forward.

[0100] As shown in FIG. 11 and FIG. 14 to FIG. 19, the body 3 of the needleless syringe has a base 31 and an inner The injection device further includes an elastic actuating mechanism located between the injection portion and the plunger 33. The elastic actuating mechanism is The elasticity of the elastic member is controlled by storing energy. The force is released to actuate the inner plunger 33 forward, so that the inner plunger 33 is pushed forward. The tapped rod 22 is pulled to push the liquid in the liquid receiving cavity 215 of the liquid tube 21. It is preferable that the injection can be completed by the injection. In an embodiment, the resilient actuation mechanism may be an air spring or an air bag.

[0101] Specifically, a tip flange 33 protruding outward in the radial direction is provided at the tip of the internal pusher 33. 1a is installed, and the elastic actuation mechanism is installed between the tip flange 331a and the base 31. The actuation spring 36 is arranged in such a way that it surrounds the inner pusher 3333. The pressure sensor 34 is provided on the outer side of the pusher 33.

[0102] A screw thread is provided between the outer case 32 and the base 31, and the outer case 32 and the base 31 are fixed to each other by the screw thread. It is preferable to realize that the main case 32 moves rearward with respect to the base 31. As shown in FIG. 11, the base 31 has a rear end and a base side extending forward from the rear end. The outer case 3 includes a wall 312, and a female screw 312a is provided on the inner surface of the base side wall 312. A male screw is provided on the rear outer surface of the outer case 32. The female screw and the male screw cooperate to form the outer case 32. In the process of moving backward relative to the base, the operating spring 36 can be stably compressed. do.

[0103] The external case 32 and the internal plunger 33 are arranged so that the amount of the liquid in the medicine bottle 1 can be visually confirmed from the outside. At least a part of the portion of the container corresponding to the medicine bottle 1 in the radial direction is transparent or openwork. It is also preferred that the sensor is configured as follows:

[0104] 14 to 20 show the process from attaching the needleless syringe 4 and the medicine bottle 1 to completing the injection. The process includes, in order, a step of mounting, a step of boosting pressure and storing energy, and a step of administering the drug. It includes two main steps: an inhalation step and an injection step. Each step will be explained in turn.

[0105] FIG. 14 is a schematic diagram showing the process of mounting the injection head 2 and the medicine bottle 1 to the main body 3 of the needleless syringe. As shown in the drawing, the piston rod 22 of the injection head 2 is first inserted into the medicine bottle. 1, and then the injection head 2 and the medicine bottle 1 are integrated into the body 3 of the needleless syringe. The medicine bottle 1 enters the internal plunger 33 and moves backward until it cannot move further. Then, the piston rod 22 and the inner plunger 33 just engage and are fixed together, The liquid tube 21 and the outer case 32 are also fixed together by screw fastening.

[0106] The state of each component after the installation is completed is shown in FIG. 15. At this time, the needleless syringe 4 is a spare. In this state, the drug solution tube 21 is already fixed to the outer case 32. The piston rod 22 and the medicine bottle 1 are already fixed to the internal plunger 33. The lock mechanism 34 is in a free state, and the internal pusher 33 is locked relative to the base 31. It has not been done.

[0107] The process shown in Figures 15-16 is carried out by increasing the pressure and energy of the operating spring 36. Specifically, the outer case 32 moves backward relative to the base 31 (double 2. Rotate the outer case 32 so that the outer case 32 is in contact with the outer case 32. The tip 322 of the inner plunger 33 is attached to the tip flange 331a of the inner plunger 33, thereby When the inner case 32 is inserted, it moves backward, taking the inner plunger 33 with it. When the inner pusher 33 is fixed by the fastening, the rear end flange 333 of the inner pusher 33 is just in contact with the position limiting member 332. At this time, the position limiting member 344 engages with the rear part of the rear end flange 333. In this process, the operating spring 36 It was compressed to store energy in preparation for the final injection step.

[0108] The process shown in Figures 16 to 17 is the inhalation step of the medicine. The base 32 is moved forward relative to the base 31 (by the screw engagement between the two). However, since the internal plunger 33 is locked by the lock mechanism 34, , the base 31 is fixed to the base 31, i.e., during the process, The case 32 moves forward relative to the internal plunger 33. The drug solution tube 21 is inserted into the outer case 3. 2, and the medicine bottle 1 and the rod with piston 22 are fixed against the internal plunger 33. Since the tube 21 is fixed, the tube 21 is in the forward direction with respect to the bottle 1 and the rod 22 with the piston. Further, the injection hole 211 of the drug solution tube 21 is closed by the cap portion 23. Therefore, when the liquid medicine tube 21 moves forward relative to the piston rod 22, the liquid medicine tube The medicinal liquid receiving cavity 215 appears in the tube 21, and the pressure in the medicinal liquid receiving cavity 215 decreases. The liquid in the medicine bottle 1 passes through the medicine passage 222c in the piston rod 22. The receiving cavity 215 can be inhaled to complete the inhalation of the medicine.

[0109] The steps shown in FIG. 18 are a pre-injection step before the inhalation and injection steps of the drug. The purpose of this step is to remove any liquid that may be mixed into the drug tube 21. In this step, first, the cap part 23 is removed. Then, the outer case 32 is attached to the base 31. The outer case 32 is rotated so as to move slightly backwards in the process. The piston 33 and the piston rod 22 are fixed to the base 31 . In this way, the drug solution tube 21 actually moves slightly backward relative to the piston rod 22, The piston rod 22 lightly compresses the liquid medicine receiving cavity 215 in the liquid medicine tube 21. Only by this, the gas in the drug solution receiving cavity 215 can be discharged from the injection hole 211 by the action of pressure. Cut.

[0110] The process shown in FIG. 19 is an injection step. In this step, the outer case 32 The medicine tube 21 is fixed to the base 31, and the internal plunger 33, the medicine bottle 1 and the pin As the piston rod 22 moves forward relative to the base 31, the piston rod 22 The injection step is completed by pushing the liquid medicine in the liquid medicine receiving cavity 215. The step further includes an unlocking step and an elastic actuation step.

[0111] When an injection needs to be administered, the push button 341 at the rear end of the base 31 is pushed. , the push button 341 is moved forward so that the protruding portion 341c at the tip of the push button 341 is , the radial restriction on the position limiting member 344 is released, The position limiting member 344 can move outward along the radial direction to contact the rear end flange 33 of the inner pusher 33. 33 is unlocked, and the forward movement of push button 341 The inner plunger 33 is also pushed forward by the spring 343 and the spring housing. 344, the inner pusher 33 exceeds the position limiting member 344, thereby The locking mechanism 34 for the locking member 3 is released.

[0112] When the internal pusher 33 is unlocked, it becomes possible for it to move forward relative to the base 31 . At this time, the operating spring 36, which has already been pressurized and stored with energy, This applies a huge thrust to the tip flange 331a of the piston, causing the internal plunger 33 to The rod 22 is moved forward and the liquid in the liquid storage cavity 215 is pushed. The liquid medicine is injected through the injection hole 211.

[0113] According to the above steps, the tip flange 331a of the internal pusher 33 is at least It turns out that the system has two purposes. One is to boost pressure and store energy. In the step, when the outer case 32 moves backward relative to the base 31, the inner pusher 3 3, the inner pusher 33 is attached to the tip flange 331a of the base 3 together with the base 3 1, and finally, the internal pusher 33 reaches the lock position to lock the lock mechanism. The other purpose of the setting is to lock the operation switch at 34 during the injection step. The spring 36 is in contact with the base 31 and the tip flange 331a of the internal pusher 33. Therefore, the spring applies a thrust to the tip flange 331a, and the inner pusher 3 Push 3 forward to complete the injection.

[0114] FIG. 20 shows one modification of the above embodiment. In the needleless syringe shown in FIG. The inner pusher 33 is provided with a middle flange 331b, and the operating spring 36 is attached to the base 3. 1 and the intermediate flange 331b. The inner plunger 33 is appropriately lengthened to be long enough to provide the actuation force. Such an installation avoids the actuation spring 36 from blocking the reservoir bottle 1, thereby The volume of the medicine bottle 1 can be clearly seen from the outside.

[0115] Another modification of the above embodiment is shown in FIG. 21. The needleless syringe has an internal plunger 33 in its main body 3, and a spring is attached to the end flange 331a of the internal plunger 33. The shaft 37 is fixedly connected, and the spring shaft 37 is flatly connected to the axis X from the tip flange 331a. An operating spring 36 is mounted on a spring shaft 37 and extends rearward along the running direction. In order to apply a uniform thrust to the internal thruster 33, the spring shaft 37 is provided in a plurality of positions. Each of the spring shafts 37 is provided with one operating spring 36. It is preferable that the pushing shafts 37 are arranged around the inner pusher 33, and the arrangement is uniform. In FIG. 21, the needleless syringe may be arranged uniformly or non-uniformly. In the main body 3, two spring shafts 37 are installed, and these two spring shafts 3 7 extend along directions Y and Z, respectively, and directions Y and Z are symmetrical with respect to axis X. be.

[0116] The alternative configurations of the needleless injector shown in Figures 20 and 21 are similar to those shown in Figures 14-19. Since the above is similar to the above, a duplicated description will be omitted.

[0117] 22-28 show another embodiment of the injection head 2 and the body of the needleless syringe. As shown in FIG. 22, the main body 3 of the needleless syringe is The base 31 includes an outer case 32 and an inner pusher system 334. The base 31 is The outer case 32 has an opening facing the rear and is connected to the base 31 and the outer The outer case 32 is attached to the tip of the base 31 so as to form a storage space between the base 31 and the outer case 32. 2 has a front opening for fixedly mounting the drug solution tube 21. The stem 334 includes an internal pusher 33, and the internal pusher 33 is positioned in the receiving space and faces forward. The medicine bottle 21 is accommodated in the inner plunger 33 and is connected to the inner plunger 33. 1 and a piston-equipped rod 22 is fixedly mounted in the forward facing opening.

[0118] The external case 32 and the internal plunger 33 are arranged so that the amount of the liquid in the medicine bottle 1 can be visually confirmed from the outside. At least a part of the portion of the container corresponding to the medicine bottle 1 in the radial direction is transparent or openwork. It is preferable that the above-mentioned configuration is adopted.

[0119] The above-mentioned components may be connected in a number of different ways. For example, the outer case 32 and the liquid chamber 34 may be connected in a number of different ways. The tube 21 may be connected by a screw thread, and as shown in FIG. A male screw 213 for the drug solution tube is provided on the outer surface of the rear part of the drug solution tube 21, and the outer case 3 The female screw 322a of the housing is provided at the front opening of the housing 2, and the male screw 213 of the drug solution tube is provided at the front opening of the housing 2. The female screw 322a of the housing can be screwed into the female screw 322a of the housing, so that the drug solution tube 21 and the external cable The drug solution tube 21 is just engaged with the tip surface of the outer case 32. A position limiting flange 212 may be provided to accommodate this.

[0120] The cooperation between the piston rod 22 and the inner plunger 33 may be a snap-type cooperation. Specifically, as shown in FIG. 22, a snap is provided on the outer surface of the piston rod 22. A snap-type protrusion 222d is provided at the corresponding position of the internal pusher 33, and a snap-type recess 33a is provided at the corresponding position of the internal pusher 33. The piston is then set in place, and the snap-fit ​​protrusion 222d engages in the recess 33a, thereby The piston rod 22 is fixed to the internal plunger 33. The rear part 222a of the piston rod 22 may have a large radial dimension to match the internal plunger 33. The space inside the plunger 33 may be provided with a space of a size suitable for the medicine bottle 1, and the piston After the rod 22 and the internal plunger 33 are snapped together, the medicine bottle 1 is The medicine bottle 1 is adaptively placed in the space, and the medicine bottle 1 is placed against the internal plunger 33 in the space. There is no space to allow movement.

[0121] In this way, the outer case 32 is always in the medicine tube during the entire process of inhaling and injecting medicine. The internal plunger 33 is always in contact with the medicine bottle 1 and the rod 22 with the piston. However, there is always a gap between the outer case 32, the inner pusher 33, and the base 31. Therefore, the outer case 32 can move with the drug solution tube 21, and the inner case 32 can move with the drug solution tube 21. The plunger 33 can move together with the medicine bottle 1 and the piston 221.

[0122] Specifically, in order to realize the inhalation and injection of medicine, the outer case 32 is provided with the medicine tube 21. The internal plunger is moved back and forth relative to the medicine bottle 1 and the rod 22 with the piston. It can move back and forth with respect to the stem 334. More specifically, during the process of inhaling the medicine (FIG. 2 5), an inner pusher system 334 is fixed to the base 31, and an outer case 3 2 moves forward relative to the internal plunger 33, and during the injection process (see FIG. 27), the external casing The case 32 is fixed to the base 31, and the inner pusher system 334 is fixed to the outer case 3. Move forward to 2. The specific drug inhalation and injection process will be explained in detail later. .

[0123] The body 3 of the needleless syringe further includes a locking mechanism 34. The locking mechanism 34 is connected to the base 31. The internal plunger system 334 is connected to the internal plunger system 334 to control the internal plunger system during the drug inhalation process. The stem 334 can be locked in the axial direction relative to the base 31, and after the inhalation of the medicine is completed, 3, the inner thruster system 334 is unlocked so as to move forward relative to the outer case 32. It is preferable to use it so that

[0124] The relative rotational motion between the outer case 32 and the base 31 is converted into a relative linear motion. In order to achieve this, the outer case 32 and the base 31 are connected to each other by a screw thread. As shown in FIG. 18, the base 31 has a rear end and a base side wall 31 extending forward from the rear end. 2, and a female screw 312a is provided on the inner surface of the base side wall 312. A male screw is provided on the rear outer surface, and the female screw and the male screw cooperate to form the outer case 32. The outer case 32 and the base 31 rotate relative to each other, thereby changing the relative position of both the outer case 32 and the base 31. Provides forward and backward movement.

[0125] In order to improve the speed of inhalation of the medicine during the inhalation process, the body 3 of the needleless syringe is Further includes a refill plunger 8, the drug solution refill plunger 8 is attached to the rear end of the internal plunger 33; and The tip of the medicine refilling plunger 8 can contact the bottle cap of the medicine bottle. In order to transmit the relative movement to the drug solution refilling plunger 8, the body 3 of the needleless syringe further includes a transmission device. The transmission device includes a part connected to the drug solution refilling plunger 8 and another part connected to the base 31 or an external By directly or indirectly connecting to the case 32, the characteristics of the outer case 32 and the base 31 are During the inhalation process, the base 31 or The outer case 32 is connected to the body of the medicine bottle 1 by the liquid medicine refilling plunger 8 via a transmission device. The bottle stopper 12 is pushed forward to compress the space inside the medicine storage bottle 1.

[0126] The internal thruster system 334 further includes a transmission rod 335 that is used to cooperate with the transmission device. The tip of the transmission rod 335 is connected to the transmission device, and the rear end 3351 of the transmission rod 335 is connected to the lock mechanism. 34, and when the transmission rod 335 is locked in the lock mechanism 34, It is preferable that the transmission rod 335 is fixed to the base 31 in the rotation direction as well. Between the rod 335 and the internal thruster 33, a thrust bearing 7 is mounted.

[0127] In this embodiment, the transmission device is indirectly connected to the base 31 by the transmission rod 335. It can be seen that certain movements of the seat 31 are guided by a transmission device. In this embodiment, the transmission rod 335 is not installed, and the base 31 is directly connected to the transmission device. It is also possible.

[0128] The axis of the transmission rod 335 and the drug solution refilling plunger 7 is the axis X of the main body of the needleless syringe. The inside of the transmission rod 335 is provided with a drug solution refilling plunger housing extending along the axis X. A cavity 332 may be provided (see FIG. 29), and the liquid refilling plunger 7 is accommodated in the liquid refilling plunger accommodating cavity. The outer surface of the drug solution refilling plunger 7 is a screw surface, but the drug solution refilling plunger 7 is a screw surface. The surface of the liquid refilling plunger receiving cavity 332 is a smooth surface, which allows the liquid refilling plunger 7 is movable along the axial direction within the drug solution refilling plunger receiving cavity 332.

[0129] In this embodiment, the base 31 rotates relative to the outer case 32 during the process of inhaling the medicine. 32, the transmission device moves forward relative to the outer case 32, and the transmission device correspondingly moves in a rotational motion. The base 31 transmits the rotational motion to the liquid medicine supply device. The force is transmitted to the plunger 8, causing it to rotate together, and pushing the bottle stopper 12 forward. In order to realize this, in order to convert the rotational motion of the drug solution refilling plunger 8 into linear motion, A motion conversion mechanism is fixedly installed in the housing space of the plunger 33. The motion conversion mechanism is A part of the liquid supply plunger 8 is joined to the liquid supply plunger 8, and another part of the liquid supply plunger 8 is joined to the internal plunger 33. Then, the liquid refilling plunger 8 is inserted into the outer case 32 (i.e., the inner plunger 33) along the base 31. and linear motion along the axial direction relative to the internal pusher 33. Convert to and.

[0130] For example, the motion conversion mechanism may include a nut member 9. The nut member 9 is a screw. The liquid supply plunger 8 is joined in a screw-type engagement. The motion conversion mechanism may include other members capable of converting relative rotational motion into relative linear motion. stomach.

[0131] More preferably, the rotary motion transmission device comprises a one-way rotary motion transmission device. The motion transmission device can transmit only one-way rotation of the transmission rod 335 to the drug solution refilling plunger 8. In other words, the unidirectional rotational motion transmission device rotates in a first direction relative to the base 31 such that the outer case 32 rotates in a first direction relative to the base 31. In the process of moving forward relative to the base 31 by rotating the transmission rod 335, The rotational motion can be transmitted to the drug solution refilling plunger 8, but the outer case 32 can rotate with respect to the base 31. In the process of moving backwards relative to the base 31 by rotating along a direction opposite to the direction Therefore, the rotational motion of the transmission rod 335 cannot be transmitted to the liquid medicine refilling plunger 8.

[0132] For example, a one-way rotary motion transmission device includes the one-way bearing shown in FIG. As shown in FIG. 30A-30B, the outer ring 61 of the one-way bearing 3 is fixed to the transmission rod 335. The inner ring 62 of the one-way bearing 6 and the liquid refilling plunger 8 are fixed in the rotation direction. The contact surface between the inner ring 62 and the liquid refilling plunger 8 is connected to the axis X. An extending guide bar or keyway may be provided to allow alignment of the inner ring 62 and the drug refill pusher. The relative rotation of the bearing 8 is restricted, but the relative linear motion in both axial directions is not restricted. stomach.

[0133] During the process of inhaling the medicine, the base 31 rotates relative to the outer case 32. The outer case 32 can be moved forward relative to the base 31, and a rotation direction having such a relative rotation direction is provided. In this movement, the outer ring 61 of the one-way bearing 6 transmits the rotational movement to the inner ring 62. The liquid refilling plunger 8 can be rotated together with the nut member. 9, and thus the inner pusher 33 ( At this time, the entire internal pusher system 334 is locked in the axial direction by the locking mechanism 34. 1) is moved forward against the medicine bottle 1, thereby pushing the bottle stopper 12 of the medicine bottle 1. The liquid medicine in the medicine bottle 1 is encouraged to enter the liquid medicine tube 21 by the action of pressure.

[0134] The rear end of the transmission rod 335 is provided with a rear end 3351 of the transmission rod 335 protruding outward in the radial direction. is installed (see FIG. 27), and the rear end 3351 of the transmission rod 335 is formed with a flange structure, The rear end 3351 is used to cooperate with the locking mechanism 34. The locking mechanism 34 is a position limiting member. A bar 344, a push button 341, a spring accommodating member 342, and a push button spring The position limiting member 344 limits the forward movement of the transmission rod 335. In order to limit the locking state, the rear end 3351 of the transmission rod 335 (which is formed with a flange structure) The push button 341 is attached to the rear end wall of the base 31 and can abut against the tip surface of the base 31. The spring accommodating member 342 protrudes rearward from the base 31, and the rear end of the transmission rod 335 A spring retainer is provided between the rear end wall of the push button 341 and the rear end wall of the push button 341. The push button spring 343 is located in the spring receiving cavity and has a rear end. Button 341 is contactable.

[0135] In this manner, the push button 341 includes a push button spring 343 and a spring housing member 342 is pushed to indirectly push the transmission rod 335. , whereby the rear end 3351 of the transmission rod 335 (which is formed with a flange structure) The position limiting member 3 is rotated so that the locking mechanism 34 is released from the locking of the transmission rod 335. 44. In another embodiment not shown, the push button spring 343 The spring receiving member 342 and other members do not need to be installed, and the push button 341 is a transmission rod. By directly pushing the transmission rod 335, the lock mechanism 34 is locked to the transmission rod 335. The lock will be released.

[0136] In this embodiment, the circumferential outer surface of the tip flange 331 of the internal pusher 33 and the outer case A motion limiting structure (not shown) is installed between the inner circumferential surface of ... The rotation of the inner pusher 33 relative to the outer case 32 can be restricted, but the inner pusher 33 It is configured to be allowed to move back and forth along the axial direction relative to the outer case 32. The motion limiting structure may be, for example, a circumferential outer surface of the tip flange 331 and a circumferential outer surface of the inner housing 32. It may be a keyway or a guide bar formed on the facing inner surface and extending in the axial direction.

[0137] Due to the installation of the movement limiting structure, during the process of boosting and inhaling the medicine, the internal plunger 33 is The entire internal plunger system 334 is a locking mechanism. When locked with 34, the inner plunger 33 rotates together with the outer case 32. It can move in a straight line, but it cannot.

[0138] There is a specific connection relationship between the internal pusher 33 and the transmission rod 335. The outer circumferential surface of the transmission rod cooperating portion 3352 at the tip of the inner plunger 33 comes into contact with the inner circumferential surface of the inner plunger 33 to cooperate with the transmission rod cooperating portion 3352. The two members move together, and there is a large sliding friction between them (e.g., the contact surfaces of both members are rough), and one of the members When no external force is applied, one member can rotate along with the other member. However, when both members are subjected to external force, When both are in the same position, they can rotate around each other.

[0139] Specifically, when the transmission rod 335 is not locked by the lock mechanism 34, for example, During this process, the transmission rod 335 can rotate together with the internal pusher 33. Since the rotating direction is not the transmission direction of the one-way bearing 6, the outer ring 61 of the one-way bearing 6 rotates. The rotational motion is not transmitted to the inner ring 62, and at this time, the liquid refilling plunger 8 is connected to the nut member 9. The liquid refilling plunger 33 moves linearly while being indirectly moved by the internal plunger 33. No relative displacement occurs between the lock mechanism 34 and the internal pusher 33. When locked, the transmission rod 335 can only rotate according to the lock mechanism 34. For example, during the process of inhaling medicine, the rotation direction of the transmission rod 335 coincides with the rotation direction of the base 31, The rotation direction of the inner pusher 33 does not match the rotation direction of the outer case 32, and the inner pusher 33 and the transmission rod 33 5, but the entire internal plunger system 334 is a locking mechanism. Since the mechanism 34 is locked, the internal pusher 33 can only rotate relative to the transmission rod 335. It does not move parallel to it.

[0140] 22 to 28 show the process from attaching the needleless syringe 4 and the medicine bottle 1 to completing the injection. The process includes, in order, a step of mounting, a step of boosting pressure and storing energy, and a step of administering the drug. It includes two main steps: an inhalation step and an injection step. Each step will be explained in turn.

[0141] FIG. 22 is a schematic diagram showing the process of mounting the injection head 2 and the medicine bottle 1 to the main body 3 of the needleless syringe. As shown in the drawing, the piston rod 22 of the injection head 2 is first inserted into the medicine bottle 1. Then, the injection head 2 and the medicine bottle 1 are inserted into the body 3 of the needleless syringe as a whole. The vial 1 enters the internal plunger 33 and moves backwards until it cannot move further. Then, the piston rod 22 and the inner plunger 33 are just engaged and fixed together, and the drug solution The tube 21 and the outer case 32 are also fixed together by screw fastening.

[0142] The state of each component after the installation is completed is shown in FIG. 23. At this time, the needleless syringe 4 is a spare. In this state, the drug solution tube 21 is already fixed to the outer case 32. The piston rod 22 and the medicine bottle 1 are already fixed to the internal plunger 33. The lock mechanism 34 is in a free state, and the internal pusher 33 is locked to the base 31. Not yet.

[0143] The process shown in Figures 23-24 is carried out by increasing the pressure and energy of the actuating spring 36. Specifically, the outer case 32 moves backward relative to the base 31 (double 2. Rotate the outer case 32 so that the outer case 32 is in contact with the outer case 32. The tip 322 of the inner plunger 33 rotates together with the inner plunger 33, thereby The outer case 32 is fixed to the base 31 by screws. Then, the rear end 3351 of the transmission rod 335 (which is formed with a flange structure) is just At this time, the position limiting member 344 engages with the rear part of the transmission rod 3 35 (which is formed with a flange structure) abuts against the front surface of the rear end 3351 of the inner plunger shaft 335. In the process, the actuation spring 36 locks the last injection stem 334. It was compressed and stored energy to prepare for the launch.

[0144] The process shown in Figures 24 to 25 is the inhalation step of the medicine. The base 32 is moved forward relative to the base 31 (by the screw engagement between the two). However, since the internal plunger 33 is locked by the lock mechanism 34, , the base 31 is fixed to the base 31, i.e., during the process, The case 32 moves forward relative to the inner plunger 33 (but does not rotate with it). The liquid tube 21 is fixed to the outer case 32, and the medicine bottle 1 and the rod with the piston are Since the plunger 22 is fixed to the internal plunger 33, the liquid medicine tube 21 is inserted into the medicine bottle 1. The injection hole 211 of the drug solution tube 21 moves forward relative to the tapped rod 22. Since the cap portion 23 is closed, the drug solution tube 21 is connected to the piston rod 22. When the tube 21 moves forward, the cavity 215 appears in the tube 21. Since the pressure at the rod 22 with the piston decreases, the liquid in the medicine bottle 1 is forced to the rod 22 with the piston. The liquid passes through the liquid medicine passage 222c and is drawn into the liquid medicine receiving cavity 215, completing the inhalation of the medicine.

[0145] During the process of inhaling the medicine, the transmission rod 335 is inserted into the outer case 32 together with the base 34. The transmission rod 335 rotates relative to the liquid supply plunger 8, and the transmission rod 335 transmits the rotational motion to the liquid supply plunger 8 via the one-way bearing 6. The liquid refilling plunger 8 rotates relative to the nut member 9. 8 is realized to move forward relative to the nut member, i.e., the inner pusher 33. The tip 81 of the medicine refilling plunger 8 (see FIG. 22) pushes the bottle cap 12 to further fill the medicine bottle 1. This compresses the space within the cavity 215, thereby encouraging the medicinal fluid to flow into the medicinal fluid receiving cavity 215.

[0146] The steps shown in FIG. 26 are a pre-injection step before the inhalation and injection steps of the drug. The purpose of this step is to remove any liquid that may be mixed into the drug tube 21. In this step, first, the cap part 23 is removed. Then, the outer case 32 is attached to the base 31. The outer case 32 is rotated so as to move slightly backwards in the process. The piston 33 and the piston rod 22 are fixed to the base 31 . In this way, the drug solution tube 21 actually moves slightly backward relative to the piston rod 22, The piston rod 22 lightly compresses the liquid medicine receiving cavity 215 in the liquid medicine tube 21. Only by this, the gas in the drug solution receiving cavity 215 can be discharged from the injection hole 211 by the action of pressure. Cut.

[0147] The process shown in FIG. 27 is an injection step. In this step, the outer case 32 The medicine tube 21 is fixed to the base 31, and the internal plunger 33, the medicine bottle 1 and the pin As the piston rod 22 moves forward relative to the base 31, the piston rod 22 The injection step is completed by pushing the liquid medicine in the liquid medicine receiving cavity 215. The step further includes an unlocking step and an elastic actuation step.

[0148] When an injection needs to be administered, the push button 341 at the rear end of the base 31 is pushed. , the push button 341 is moved forward so that the protruding portion 341c at the tip of the push button 341 is , the radial restriction on the position limiting member 344 is released, The position limiting member 344 can move outward along the radial direction to the rear end 3351 (and The lock against the flange structure is released, and the push button 341 The forward movement of the internal push button is actuated by the push button spring 343 and the spring housing. The system 334 can also be pushed forward, and the transmission rod 335 moves the position limiting member 344 3, thereby unlocking the locking mechanism 34 from the internal plunger system 334. will be removed.

[0149] The internal pusher system 334 is adapted to move forward relative to the base 31 when unlocked. At this time, the operating spring 36, which has already undergone pressure boosting and energy storage, A huge thrust is applied to the tip flange 331a of the plunger 33, thereby causing the inner plunger 33 The piston rod 22 moves forward and pushes the liquid in the liquid storage cavity 215. Then, the liquid medicine is injected through the injection hole 211.

[0150] According to the above steps, the tip flange 331a of the internal pusher 33 is at least It was found that the refrigeration equipment also has two installation purposes. One of the installation purposes is to boost pressure and store energy. In the stacking step, when the outer case 32 moves backward relative to the base 31, the inner pusher By adding the tip flange 331a of 33, the inner pusher 33 is brought together with the base 31, and finally the internal pusher 33 reaches the locking position to form the locking mechanism. The other purpose of the mechanism is to lock the injection step by the mechanism 34. The spring 36 is in contact with the base 31 and the tip flange 331a of the internal pusher 33. Therefore, the spring applies a thrust to the tip flange 331a, and the internal thruster Push 33 forward to complete the injection.

[0151] After completing one injection, the next injection may be performed without removing the medicine bottle 1. That is, the liquid medicine in the medicine bottle 1 can supply multiple injections. Then, after multiple injections, The bottle stopper 12 of the medicine bottle 1 is continuously inserted by the medicine refilling plunger 8 (continuously in space). is understood as being pushed forward (referring to the fact that the Figures 28 and 29 show the structure of the body of the needleless syringe after multiple injections are completed. .

[0152] Now, if you try to push the liquid refill plunger 8 backward to its initial position, Then, the operation of rotating the chemical solution refilling plunger 8 relative to the nut member 9 can be selected. In order to accelerate the operation, the nut member 9 is The nut member 9 is adapted to be moved backwards directly with respect to the nut member 9 under the condition that the nut member 9 does not rotate relative to the nut member 9. It is preferable to install a nut member 9 in the groove.

[0153] To achieve this purpose, the nut member 9 is made up of at least two nut members that are spaced apart from each other. A nut member may be provided, and at least two nut members may be provided radially in a specific condition. The liquid supply plunger 8 can move outward along the direction of the arrow, thereby joining or separating from the liquid supply plunger 8. 1 through 34B show three examples.

[0154] In the example shown in Figures 31 to 34B, at least two nut members are The nut members are arranged around the liquid replenishment plunger 8, and each nut member is joined or connected to the liquid replenishment plunger 8. can move radially toward or away from the axis so as to disengage.

[0155] In the example shown in Figures 31-32B, there are two nut members 9a, A nut position limiting member 91a is installed at the tip of the nut member 9a. The surface in contact with the nut position limiting member 91a at a is the force receiving slope. The end of the needle is radially away from the axis X of the needleless syringe from the tip of the needle. The member 91a is a wedge-shaped block, and the wedge-shaped block forms a force application slope that contacts the force receiving slope. Prepare.

[0156] As shown in FIG. 32A, when the vial 1 is mounted in the needleless syringe, However, the nut position limiting member 91a can be pushed backward, and the nut position limiting member The nut member 91a applies a force to the force-receiving slope of the nut member 9a, but the force is received by the force-receiving slope. Since the pressure applied to the nut member 9a is perpendicular to the inclined surface, the pressure applied to the nut member 9a is The syringe has a component of an action force directed inward along a radial direction of the body of the syringe, and the component of the action force is The nut member 9a is firmly pressed and joined to the chemical solution refill plunger 8.

[0157] As shown in FIG. 32B, after the medicine bottle 1 is removed, the nut position limiting member 9 1a slides forward, the pressure applied to the nut member 9a decreases, and the nut member 9a It moves outward along the radial direction, thereby joining or separating from the drug solution refilling plunger 8. At this time, the drug solution refill plunger 8 can be directly pushed backward to the initial position.

[0158] The rear end of the nut position limiting member 91a is provided with a nut position limiting member 91a that moves rearward. In order to prevent excessive force from being applied to the nut member 9a due to the width being too large, It is preferable that a second position limiting member 92a is further provided so as to limit the distance between the first position limiting member 92 and the second position limiting member 92a.

[0159] The illustrations in Figures 33A and 33B are similar to those in Figures 32A and 32B, but Instead of a wedge-shaped block, a nut position limiting member 91b formed in an annular structure is used. The annular structure has a common axis with the body 3 of the needleless syringe, and the axis X is located A cross section cut along a plane (as shown in Figures 33A and 33B) is circular. In such an embodiment, the connection between the nut position limiting member 91b and the nut member 9b The contact form is point contact.

[0160] In the state shown in FIG. 33A, the nut position limiting member 91b is The nut member 9b is firmly pressed against the chemical refilling plunger 8 until it is firmly connected to the chemical refilling plunger 8. In the state shown in FIG. 33B, the medicine bottle 1 has already been removed and the nut The position limiting member moves forward, and the nut member 9b moves radially outward. , whereby the liquid refilling plunger 8 is joined to or separated from the liquid refilling plunger 8.

[0161] In an embodiment not shown in the drawings, the nut position limiting member is formed into a spherical structure. A ball may be provided at the tip of the radially outer edge of the nut member. The nut position limiting member should be limited in the spherical groove. I can't get out from inside.

[0162] The structures shown in Figures 34A and 34B are more preferred. The filling plunger 8 applies an axial force to the nut member 9c (i.e., the immediate chemical solution filling plunger 8 is a movement along the axial direction when there is no relative rotation with respect to the nut member 9c When the force reaches a predetermined threshold value, the nut member 9c is The refill plunger is configured to move outward along the direction to disengage from the refill plunger.

[0163] That is, when it is necessary to push the liquid refilling plunger 8 to its original position, By simply pushing backward, the nut member 9c naturally moves outward along the radial direction. 4, and allows the drug solution refilling plunger 8 to move parallel to the axis.

[0164] At the same time, not only when the liquid refilling plunger 8 receives a backward force, Even when the nut member 98 is subjected to a forward thrust and the thrust reaches a predetermined threshold value, c is configured to move outward along the radial direction to disengage from the liquid refilling plunger. In the process of use, when the thrust force that the liquid refill plunger 8 can withstand is too large, The nut member 9c disengages from it, thereby fulfilling the function of protecting the medicine bottle. Add.

[0165] The present invention provides an injection head of a needleless syringe, a body of a needleless syringe, and a needleless syringe. The body assembly is capable of storing the medicine bottle within the body of the needleless syringe for an extended period of time and disposing of the medicine bottle after a single use. The inhalation and injection of medicines can be completed efficiently and effortlessly; During the entire process, there is no need to take out the medicine bottle, and the medicine tube and the medicine bottle do not need to be separated. In addition, storing the medicine bottle inside the needleless syringe eliminates problems such as loss and contamination of the medicine bottle. This can prevent the occurrence of

[0166] Based on the above, a person skilled in the art may be able to implement alternative structures to those disclosed in the present invention. Alternatively, the disclosed embodiments may be combined to form new embodiments. It is possible to create configurations that fall within the scope of the appended claims. I can understand this.

Claims

1. A needleless syringe body for use in combination with a medicine bottle including a bottle body having a medicine bottle receiving cavity and a bottle stopper that can slide back and forth within the medicine bottle receiving cavity relative to the bottle body, and an injection head, The body (3) of the needleless syringe is A base (31) having a forward-facing opening; an outer case (32) having a rearward opening, attached to the tip of the base so as to form a storage space between the base and the outer case, and having a front opening for fixedly attaching a drug solution tube; an internal plunger system (334) including an internal plunger (33) located in the storage space and having a forward opening, the medicine bottle being fixedly accommodated in the internal plunger and a rod with a piston being fixed to the forward opening; a medicine liquid refilling plunger (8) attached to the rear end of the internal plunger and having a tip capable of contacting the bottle cap of the medicine storage bottle; a transmission device, a part of which is connected to the drug solution refilling plunger (8) and another part of which is directly or indirectly connected to the base (31) or the outer case (32); In order to realize the inhalation and injection of medicine, the outer case can move back and forth with respect to the inner plunger, so as to take the medicine liquid tube with it and move it back and forth with respect to the medicine bottle and the piston-equipped rod; The body of the needleless syringe is characterized in that, during the process of inhaling medicine, the base or the outer case pushes the bottle stopper of the medicine storage bottle forward against the bottle body, accompanied by the medicine liquid refilling pusher, via the transmission device, so as to compress the space in the medicine storage bottle.

2. The body of the needle-free syringe according to claim 1, further comprising a locking mechanism (34) connected between the base (31) and the internal pusher system (334), the locking mechanism being configured to lock the internal pusher system relative to the base (31) in the forward and backward directions during the process of inhaling the medicine, and to unlock the internal pusher system so that it moves forward relative to the outer case (32) after inhalation of the medicine is completed.

3. The body of the needle-free syringe as described in claim 2, characterized in that the base (31) and the outer case (32) are rotatably joined to each other, and relative rotation between the outer case (32) and the base (31) realizes relative movement between the outer case (32) and the base (31) in the axial direction of the body of the needle-free syringe.

4. The body of the needle-free syringe described in claim 3, characterized in that the internal pusher system (334) further includes a transmission rod (335), the tip of which is connected to the transmission device and the rear end (3351) is used to connect with the locking mechanism, and when the transmission rod is locked with the locking mechanism, the transmission rod is fixed relative to the base also in the rotational direction.

5. The transmission device includes a rotational motion transmission device, and the rotational motion transmission device is configured to transmit a specific rotational motion of the transmission rod (335) to the drug solution refilling plunger (8) so as to rotate the drug solution refilling plunger (8), The body of the needle-free syringe according to claim 4, characterized in that a motion conversion mechanism is provided within the body of the needle-free syringe, and a part of the motion conversion mechanism is joined to the drug solution refilling pusher (8) and another part of the motion conversion mechanism is joined directly or indirectly to the internal pusher (33) so as to convert the rotational motion of the drug solution refilling pusher (8) accompanying the transmission rod (335) into linear motion relative to the internal pusher (33) along the axial direction of the body of the needle-free syringe.

6. During the process of inhaling the medicine, the outer case (32) rotates relative to the base (31) and moves forward relative to the base (31); The body of the needle-free syringe according to claim 5, characterized in that the rotational motion transmission device includes a one-way rotational motion transmission device, which is configured to transmit the rotational motion of the transmission rod (335) to the drug solution refilling pusher (8) when the outer case (32) rotates relative to the base (31) and moves forward relative to the base, but cannot transmit the rotational motion of the transmission rod to the drug solution refilling pusher when the outer case (32) rotates relative to the base and moves backward relative to the base (31).

7. The body of the needle-free syringe according to claim 6, characterized in that the one-way rotational motion transmission device includes a one-way bearing (6), an outer ring (61) of the one-way bearing is fixedly connected to the transmission rod (335), and an inner ring (62) of the one-way bearing (6) and the drug solution refilling pusher (8) are connected so as to be fixed in the rotational direction around the axis of the needle-free syringe body.

8. The body of the needle-free syringe according to claim 5, characterized in that the motion conversion mechanism includes a nut member (9) that is installed in the accommodating space of the internal plunger (33) and fixedly connected to the internal plunger, and the drug solution refilling plunger (8) is joined to the nut member (9) in the form of a screw thread engagement.

9. The body of the needle-free syringe according to claim 8, characterized in that the nut member includes at least two nut members that are separated from each other, the at least two nut members are arranged around the drug solution refilling pusher, and the nut members can move toward or away from the axis of the needle-free syringe body along the radial direction of the needle-free syringe body so as to be engaged with or disengaged from the drug solution refilling pusher.

10. The body of the needle-free syringe according to claim 9, characterized in that the at least two nut members (9c) are configured such that when the drug solution refilling pusher (8) applies an acting force to the nut member (9c) along the axial direction of the body of the needle-free syringe and the acting force reaches a predetermined threshold value, the at least two nut members (9c) move in the radial direction away from the axis to release their connection with the drug solution refilling pusher.

11. The body of the needle-free syringe according to claim 10, characterized in that an elastic member (91c) is attached between the circumferential outer surface of the nut member (9c) and the circumferential inner surface of the internal pusher (33), and when the connection between the two nut members and the drug solution refill pusher is released, the elastic member is compressed.

12. The body of the needle-free syringe further includes nut position limiting members (91a, 91b) installed at the tip of each of the nut members (9a, 9b), a surface of the nut member that comes into contact with the nut position limiting member is a force receiving inclined surface, a rear end of the force receiving inclined surface is radially separated from the axis of the needle-free syringe further than the tip of the force receiving inclined surface, the nut position limiting member is configured to be able to push the force receiving inclined surface rearward so as to press the nut member until it comes into contact with the drug solution refilling pusher, and when the nut position limiting member stops applying force to the nut member, the nut members move away from each other along the radial direction to release their connection with the drug solution refilling pusher.

13. The body of the needle-free syringe as described in claim 12, characterized in that when the medicine bottle is attached to the internal plunger, the rearward acting force of the bottle body can be continuously pressed against the nut member, and after the medicine bottle is removed from the internal plunger, the tip of the nut position limiting member can directly contact the rear end of the bottle body of the medicine bottle so that the nut position limiting member stops applying force to the nut member.

14. The body of the needle-free syringe according to claim 13, characterized in that the nut position limiting member (91a) is a wedge-shaped block, and the wedge-shaped block has a force applying slope that contacts the force receiving slope.

15. The body of the needleless syringe according to claim 13, characterized in that the nut position limiting member has a spherical structure, and a spherical motion groove is provided at the tip position of the radial outer edge of the nut member, so that the nut position limiting member is restricted within the spherical motion groove and cannot be removed therefrom.

16. The body of the needle-free syringe according to claim 13, characterized in that the nut position limiting member (91b) is an annular structure having a common axis with the body of the needle-free syringe, and the cross section of the annular structure cut along a plane on which the axis is located is circular.

17. A rear end flange is provided at the rear end of the internal thruster system, the rear end flange protruding outward along a radial direction, and the locking mechanism includes: a position limiting member (34) configured to be able to abut against a front end surface of the rear end flange in a locked state so as to limit forward movement of the internal thruster system; a push button (341) attached to a rear end wall of the base and protruding rearward relative to the base; The body of the needle-free syringe according to claim 2, characterized in that the push button is configured to be pushed so as to move forward relative to the base and directly or indirectly apply a thrust force to a rear end surface of the internal pusher system, and the thrust force allows the rear end flange of the internal pusher system to surpass the position limiting member so as to unlock the locking mechanism for the internal pusher system.

18. The locking mechanism includes: a spring receiving member (342) disposed between a rear end surface of the internal pusher system and a rear end wall of the push button, the spring receiving member having a spring receiving cavity opening to the rear; a push button spring (343) located in the spring receiving cavity, the rear end of which is capable of contacting the push button; The body of the needle-free syringe according to claim 17, characterized in that the push button can be pushed to indirectly apply a thrust to the internal pusher system via the push button spring and the spring housing member.

19. the push button includes a rear end wall and a side wall extending forward from the rear end wall and surrounding the axis, a protruding portion (341c) protruding toward the axis of the body of the needle-free syringe is provided at a tip of the side wall, and the position limiting member is configured to be movable along a radial direction with respect to the axis relative to the push button, The body of the needle-free syringe according to claim 17, characterized in that in a locked state, the protrusion abuts against the radial outside of the position limiting member, thereby restricting the position limiting member from moving radially outward, and when the push button is pushed, the protrusion moves forward relative to the position limiting member, thereby releasing the radial position restriction on the position limiting member, at which time the position limiting member can move radially outward to release contact with the tip surface of the rear end flange so as to release the lock on the internal pusher system.

20. The body of the needle-free syringe according to claim 19, characterized in that the position limiting member is a sphere, and the rear end surface (341d) of the protruding portion and the tip surface 333 of the rear end flange are both inclined surfaces, so that the position limiting member can roll and come into contact with the inclined surfaces during the process of unlocking.

21. The body of the needle-free syringe according to claim 2, wherein the locking mechanism is an electromagnet.

22. The body of the needle-free syringe according to claim 1, further comprising an elastic actuation mechanism located between the base and the internal pusher system, the elastic actuation mechanism being configured to be operated to store energy before an injection, and to be released after storing energy so as to actuate the internal pusher system forward by an elastic force to complete the injection.

23. The body of the needle-free syringe according to claim 22, characterized in that a tip flange (331a) protruding radially outward is provided at the tip of the internal pusher, and the elastic actuating mechanism includes an actuating spring (36) installed between the tip flange and the base.

24. The body of the needle-free syringe according to claim 23, wherein the actuating spring is provided outside the internal plunger so as to surround the internal plunger.

25. The body of the needle-free syringe according to claim 23, characterized in that a spring shaft (37) is fixedly connected to the tip flange of the internal plunger, the spring shaft is parallel to the axis of the internal plunger, and the operating spring (36') is arranged to surround the spring shaft.

26. The body of the needle-free syringe according to claim 25, characterized in that there are a plurality of spring shafts, and for each spring shaft, one operating spring is provided surrounding the spring shaft, and each spring shaft is arranged around the internal plunger.

27. The body of the needle-free syringe according to claim 22, characterized in that an intermediate flange (331b) is provided at the intermediate portion of the internal pusher along its circumferential direction, and the elastic actuating mechanism includes an actuating spring provided between the intermediate flange and the base.

28. The body of the needle-free syringe according to claim 23, characterized in that the base includes a rear end and a base side wall (312), a female thread (312a) is provided on the inner surface of the base side wall, a male thread corresponding to the female thread is provided on the rear outer surface of the outer case, and the female thread is screwed into the male thread, allowing the outer case to move rearward relative to the base so as to stably compress the actuation spring.

29. The body of the needle-free syringe according to claim 1, characterized in that at least a portion of the outer case and the inner plunger that radially correspond to the medicine bottle are transparent or openwork so that the amount of medicinal liquid in the medicine bottle can be visually confirmed from the outside.

30. The body of the needle-free syringe according to claim 1, characterized in that an internal plunger flange is provided on the outer periphery of the internal plunger, protruding outward along a radial direction, the circumferential outer surface of the internal plunger flange is in contact with the circumferential inner surface of the external case, and a movement limiting structure is provided on the circumferential outer surface of the internal plunger flange and the circumferential inner surface of the external case, the movement limiting structure is configured to limit the internal plunger from rotating relative to the external case but to allow the internal plunger to move back and forth relative to the external case.

31. The body of the needle-free syringe according to claim 30, characterized in that the movement limiting structure includes a key groove or a guide bar formed on the circumferential outer surface of the internal plunger flange and the circumferential inner surface of the external case and extending in the axial direction of the body of the needle-free syringe.

32. A needle-free injector (4) comprising a needle-free injector body according to any one of claims 1 to 31 and an injection head used in combination with said needle-free injector body.

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