Hemodialysis system

Abstract

A hemodialysis system capable of suppressing fluctuations in the dissolved hydrogen concentration of a dialysis fluid is provided. [Solution] The hemodialysis system 100 includes a hydrogen addition device 1 that adds hydrogen to water, a dialysis water production device 2 that produces water for dialysis, a dialysis fluid preparation device 3 that mixes medicinal drugs with the dialysis water to prepare dialysis fluid, a concentration adjustment device 4 that adjusts the dissolved hydrogen concentration in the dialysis fluid, and a dialysis device 5 that filters the patient's blood using the dialysis fluid.

Description

[Technical field]

[0001] The present invention relates to a hemodialysis system. [Background technology]

[0002] In recent years, dialysis treatment using dialysis fluid with hydrogen gas dissolved in it has been attracting attention. For example, it is known that electrolytic hydrogen water produced by electrolyzing water contributes to reducing oxidative stress in patients (for example, see Patent Document 1 below). [Prior art documents] [Patent documents]

[0003] [Patent Document 1] JP 2015-139475 A Summary of the Invention [Problem to be solved by the invention]

[0004] In a hemodialysis system, a hydrogen addition device is used to add hydrogen to water to generate a dialysis fluid containing dissolved hydrogen gas. In such a system, it is desirable to operate the dialysis fluid with a desired dissolved hydrogen concentration.

[0005] However, when there is a waiting period before the start of treatment after hydrogen addition, the dissolved hydrogen concentration in the dialysis fluid gradually decreases.The dissolved hydrogen concentration in the dialysis fluid also gradually decreases when the dialysis fluid travels along the path from the hydrogen addition device to the dialysis device.

[0006] For this reason, in dialysis treatment for multiple people using multiple dialysis machines, the route through which the dialysis fluid is supplied to each dialysis machine is different, so the dissolved hydrogen concentration of the dialysis fluid may vary from machine to machine. If the dissolved hydrogen concentration of the dialysis fluid varies, it becomes difficult to provide treatment that is appropriate for the patient's constitution and symptoms.

[0007] The present invention has been devised in view of the above circumstances, and has as its main object to provide a hemodialysis system capable of suppressing fluctuations in the dissolved hydrogen concentration of the dialysis fluid. [Means for solving the problem]

[0008] The hemodialysis system of the present invention comprises: A dialysis water generating device that purifies the supplied water and generates dialysis water; a dialysis fluid preparation device for mixing a drug with the dialysis water to prepare a dialysis fluid to be used in hemodialysis treatment; a dialysis device for filtering the patient's blood using the dialysis fluid; A hydrogen addition device that adds hydrogen to at least one of the water supplied to the dialysis water generating device, the dialysis water generated by the dialysis water generating device, and the dialysis fluid prepared by the dialysis fluid preparation device; and a concentration adjusting device for adjusting the dissolved hydrogen concentration of the dialysis fluid used by the dialysis device. Effect of the Invention

[0009] Since the hemodialysis system of the present invention has the above-mentioned configuration, it is possible to suppress fluctuations in the dissolved hydrogen concentration of the dialysis fluid and maintain the dissolved hydrogen concentration at a desired level. [Brief description of the drawings]

[0010] [Figure 1] 1 is a block diagram showing a schematic configuration of a hemodialysis system according to the present invention. [Diagram 2] FIG. 2 is a diagram showing a detailed configuration of the hydrogenation apparatus of FIG. [Diagram 3] FIG. 2 is a block diagram showing a modification of the hemodialysis system of FIG. 1. [Figure 4] FIG. 2 is a block diagram showing another modified example of the hemodialysis system of FIG. 1. [Diagram 5] FIG. 2 is a block diagram showing yet another modified example of the hemodialysis system of FIG. 1. [Figure 6] FIG. 7 is a block diagram showing a modification of the hemodialysis system of FIG. 5. [Figure 7] FIG. 7 is a block diagram showing a modification of the hemodialysis system of FIG. 6. [Figure 8] FIG. 7 is a block diagram showing a modification of the hemodialysis system of FIG. 6. DETAILED DESCRIPTION OF THE PREFERRED EMBODIMENTS

[0011] Hereinafter, an embodiment of the present invention will be described with reference to the drawings. 1 shows the flow path configuration of a hemodialysis system 100 of this embodiment. The hemodialysis system 100 of this embodiment includes a hydrogen addition device 1, a dialysis water production device 2, a dialysis fluid preparation device 3, a concentration adjustment device 4, and a dialysis device 5.

[0012] The hydrogen addition device 1 adds hydrogen to water supplied to the dialysis water production device 2. The hydrogen addition device 1 of this embodiment is disposed upstream of the dialysis water production device 2. Raw water is supplied to the hydrogen addition device 1.

[0013] Tap water is generally used as the raw water, but other water sources such as well water and groundwater can also be used. The raw water is pretreated, such as by softening, before being supplied to the hydrogen addition device 1. The raw water to which hydrogen has been added by the hydrogen addition device 1 is supplied to the dialysis water production device 2 as dissolved hydrogen water.

[0014] 2 shows details of the hydrogen addition device 1 of this embodiment. The hydrogen addition device 1 includes an electrolytic cell 11 that generates hydrogen gas by electrolyzing supplied raw water, and a control unit 16 that controls the electrolytic cell 11.

[0015] The electrolytic cell 11 has an electrolysis chamber 12 in which electrolysis is carried out, a diaphragm 13, an anode current collector 14, and a cathode current collector 15.

[0016] The electrolysis chamber 12 is divided by a diaphragm 13 into an anode chamber 12a on the anode power supply 14 side and a cathode chamber 12b on the cathode power supply 15 side. Raw water is supplied to the anode chamber 12a and the cathode chamber 12b via, for example, a bifurcated flow path (not shown).

[0017] For example, a solid polymer membrane is used as the diaphragm 13. An anode current collector 14 is disposed on one side of the diaphragm 13, and a cathode current collector 15 is disposed on the other side.

[0018] A direct current is supplied to the anode power supply 14 and the cathode power supply 15. The direct current supplied to the anode power supply 14 and the cathode power supply 15 is controlled by the control unit 16.

[0019] The control unit 16 controls each part of the hydrogenation apparatus 1. The control unit 16 has, for example, a CPU (Central Processing Unit) that executes various arithmetic processing, information processing, etc., and a memory that stores a program that controls the operation of the CPU and various information. Various functions of the control unit 16 are realized by the CPU, the memory, and the program.

[0020] The control unit 16 feedback controls the electrolysis voltage applied to the anode power supply 14 and the cathode power supply 15 so that the electrolysis current supplied to the anode power supply 14 and the cathode power supply 15 becomes a preset desired value. For example, if the electrolysis current is excessively large, the control unit 16 reduces the voltage, and if the electrolysis current is excessively small, the control unit 16 increases the voltage. This allows the electrolysis current to be appropriately controlled. The electrolysis current is measured, for example, by a measuring unit provided in a circuit that supplies power to the anode power supply 14 and the cathode power supply 15.

[0021] Of the electrolyzed water electrolyzed in the electrolytic cell 11, the electrolyzed water produced in the cathode chamber 12b is sent to the dialysis water production device 2 as cathode water. On the other hand, the electrolyzed water produced in the anode chamber 12a is discharged to the outside of the hydrogen addition device 1 as anode water.

[0022] As a result of water being electrolyzed in the electrolysis chamber 12, oxygen gas is generated in the anode chamber 12a and hydrogen gas is generated in the cathode chamber 12b.

[0023] The oxygen gas generated in the anode chamber 12a dissolves in the electrolytic water in the anode chamber 12a, is taken out of the anode chamber 12a as anode water, and is discharged to the outside of the hydrogen addition apparatus 1.

[0024] The hydrogen gas generated in the cathode chamber 12b dissolves in the electrolytic water in the cathode chamber 12b, is extracted from the cathode chamber 12b as cathode water, and is sent to the dialysis water generating device 2. That is, the cathode water sent from the cathode chamber 12b to the dialysis water generating device 2 is electrolyzed in the cathode chamber 12b and is electrolytic hydrogen water in which hydrogen gas is dissolved.

[0025] The hydrogen addition device 1 may have a configuration including the electrolytic cell 11 described above, or may be, for example, a device in which hydrogen gas generated by, for example, chemically reacting water with magnesium is dissolved in water, or a device in which pressurized hydrogen gas inside a cylinder or the like is dissolved in water.

[0026] A tank for storing the generated electrolyzed hydrogen water may be provided at or downstream of the hydrogen addition device 1. This configuration makes it possible to supply a large amount of electrolyzed hydrogen water to the dialysis water generation device 2 at once, making it easily suitable for dialysis treatment for a large number of people.

[0027] The dialysis water generating device 2 is disposed between the hydrogen addition device 1 and the dialysis fluid preparation device 3. The dialysis water generating device 2 purifies the water supplied from the hydrogen addition device 1 to generate dialysis water. As a form for realizing such a configuration, for example, a reverse osmosis treatment device can be mentioned.

[0028] The reverse osmosis treatment device uses a reverse osmosis membrane to filter the water supplied from the hydrogen addition device 1. The reverse osmosis treatment device includes a reverse osmosis membrane module having a reverse osmosis membrane, and a pump for pumping the water supplied from the hydrogen addition device 1 to the reverse osmosis membrane module.

[0029] In the hemodialysis system 100, the dialysis water producing device 2 may be a filtering method other than reverse osmosis that satisfies the standards for dialysis water, for example, one that utilizes an ion exchange (EDI: Electro-deionization) module.

[0030] Since hydrogen is dissolved in the water supplied from the hydrogen addition device 1, hydrogen is also dissolved in the dialysis water generated by the dialysis water generation device 2. That is, hydrogen water for dialysis is generated by the dialysis water generation device 2. The hydrogen water for dialysis generated by the dialysis water generation device 2 is supplied to the dialysis fluid preparation device 3.

[0031] A tank for storing the generated hydrogen water for dialysis may be provided in the dialysis water generating device 2 or downstream thereof. With this configuration, a large amount of hydrogen water for dialysis can be supplied to the dialysis fluid preparation device 3 at once, which is easily suitable for dialysis treatment for a large number of people. The dialysis water generating device 2 may be provided with a pressure reducing valve for degassing hydrogen gas contained in the dialysis water.

[0032] The dialysis fluid preparation device 3 is disposed between the dialysis water production device 2 and the concentration adjustment device 4. The dialysis fluid preparation device 3 mixes a drug with the hydrogen water for dialysis produced by the dialysis water production device 2 to prepare the dialysis fluid to be used in hemodialysis treatment. As the drug to be mixed with the hydrogen water for dialysis, a liquid dialysis base agent as well as a powdered dialysis base agent are used.

[0033] Since hydrogen is dissolved in the hydrogen water for dialysis supplied from the dialysis water generating device 2, hydrogen is also dissolved in the dialysis fluid prepared by the dialysis fluid preparing device 3.

[0034] A tank for storing the generated dialysis fluid may be provided in the dialysis fluid preparation device 3 or downstream thereof. This configuration makes it possible to supply a large amount of hydrogen water for dialysis to the dialysis device 5 at once, making it easy to adapt to dialysis treatment for a large number of people. The dialysis fluid preparation device 3 may be provided with a pressure reducing valve for degassing hydrogen gas contained in the dialysis fluid.

[0035] The concentration adjusting device 4 is disposed between the dialysis fluid preparation device 3 and the dialysis device 5. The concentration adjusting device 4 may be disposed in the dialysis fluid preparation device 3 or in a tank provided downstream thereof. The concentration adjusting device 4 may also be disposed in the dialysis device 5. The concentration adjusting device 4 adjusts the dissolved hydrogen concentration of the dialysis fluid prepared by the dialysis fluid preparation device 3.

[0036] The concentration adjusting device 4 may be disposed between the dialysis water generating device 2 and the dialysis fluid preparation device 3. In this case, the concentration adjusting device 4 adjusts the dissolved hydrogen concentration of the dialysis water supplied to the dialysis fluid preparation device 3, thereby adjusting the dissolved hydrogen concentration of the dialysis fluid.

[0037] The concentration adjusting device 4 may be a device for increasing the concentration of dissolved hydrogen in the dialysis fluid, or a device for decreasing the concentration of dissolved hydrogen in the dialysis fluid.

[0038] An example of an apparatus for increasing the dissolved hydrogen concentration in the dialysis fluid is one having a configuration similar to that of the hydrogen addition apparatus 1. In other words, the concentration adjustment apparatus 4 may be one including the electrolytic cell 11 shown in Fig. 2, or may be, for example, an apparatus in which hydrogen gas generated by chemically reacting water with magnesium is dissolved in the dialysis fluid, or an apparatus in which hydrogen gas pressurized inside a cylinder or the like is dissolved in the dialysis fluid. In this case, the electrolytic cell 11 or the like constituting the hydrogen addition apparatus 1 may be configured to function as at least a part of the concentration adjustment apparatus 4.

[0039] Examples of devices for reducing the dissolved hydrogen concentration of the dialysis fluid include a device that degasses hydrogen gas contained in the dialysis fluid by opening and closing a pressure reducing valve, and a device that mixes and dilutes the dialysis fluid containing dissolved hydrogen with a dialysis fluid not containing dissolved hydrogen. In the former case, the pressure reducing valve provided in at least one of the dialysis fluid preparation device 3 or the dialysis device 5 may be configured to also function as at least a part of the concentration adjustment device 4. In addition, in a case where at least one of the dialysis water production device 2 or the dialysis fluid preparation device 3 is provided with a pressure reducing valve for degassing hydrogen gas contained in the dialysis water, the pressure reducing valve may also function as at least a part of the concentration adjustment device 4.

[0040] The dialysis fluid whose dissolved hydrogen concentration has been adjusted by the concentration adjusting device 4 is supplied to the dialysis device 5. That is, the concentration adjusting device 4 adjusts the dissolved hydrogen concentration of the dialysis fluid used by the dialysis device 5. This stabilizes the dissolved hydrogen concentration of the dialysis fluid, and a dialysis fluid having a desired dissolved hydrogen concentration is supplied to the dialysis device 5.

[0041] The dialysis device 5 filters the patient's blood using the dialysis fluid supplied from the concentration adjusting device 4. This enables dialysis treatment using the dialysis fluid in which hydrogen is dissolved. The dialysis device 5 includes, for example, a dialyzer (artificial kidney).

[0042] Blood collected from the patient's body is sent to the dialyzer. The dialyzer has a hollow fiber membrane that separates the blood from the dialysis fluid. The hollow fiber membrane purifies the blood by transferring waste products contained in the blood to the dialysis fluid. The blood purified by the dialyzer is returned to the patient's body. That is, the dialysis device 5 purifies the blood while circulating the blood between the patient's body and the dialyzer. The dialysis device 5 may be provided with a pressure reducing valve for degassing hydrogen gas contained in the dialysis fluid.

[0043] In the hemodialysis system 100, the concentration adjusting device 4 adjusts the dissolved hydrogen concentration of the dialysis fluid, thereby suppressing fluctuations in the dissolved hydrogen concentration of the dialysis fluid and making it possible to maintain a desired dissolved hydrogen concentration. This makes it possible to perform dialysis treatment using dialysis fluid with a dissolved hydrogen concentration that suits the patient's constitution and symptoms.

[0044] In the hemodialysis system of the present invention, the hydrogen addition device 1 may be configured to add hydrogen to at least one of the water supplied to the dialysis water production device 2, the dialysis water produced by the dialysis water production device 2, and the dialysis fluid prepared by the dialysis fluid preparation device 3. That is, the hemodialysis system 100 may be modified, for example, as shown below.

[0045] Fig. 3 is a block diagram of a hemodialysis system 100A which is a modified example of the hemodialysis system 100 in Fig. 1. For parts of the hemodialysis system 100A that are not described below, the configuration of the hemodialysis system 100 described above can be adopted.

[0046] In the hemodialysis system 100A, a hydrogen addition device 1 is disposed between a dialysis water production device 2 and a dialysis fluid preparation device 3.

[0047] The dialysis water generating device 2 purifies the supplied raw water to generate dialysis water. The dialysis water generated by the dialysis water generating device 2 is supplied to the hydrogen adding device 1, where hydrogen is added. This generates hydrogen water for dialysis, which is water for dialysis with hydrogen dissolved in it.

[0048] As in the hemodialysis system 100, the dialysis fluid preparation device 3 prepares dialysis fluid with dissolved hydrogen, and the concentration of dissolved hydrogen is adjusted by the concentration adjustment device 4 before being supplied to the dialysis device 5. This makes it possible to suppress fluctuations in the dissolved hydrogen concentration of the dialysis fluid. This makes it possible to perform dialysis treatment using dialysis fluid with a dissolved hydrogen concentration suited to the patient's constitution and symptoms.

[0049] Fig. 4 is a block diagram of a hemodialysis system 100B which is another modified example of the hemodialysis system 100 in Fig. 1. For parts of the hemodialysis system 100B which are not described below, the configurations of the above-mentioned hemodialysis systems 100 and 100A can be adopted.

[0050] In the hemodialysis system 100B, a hydrogen addition device 1 is disposed between a dialysis fluid preparation device 3 and a concentration adjustment device 4.

[0051] The dialysis water generating device 2 purifies the supplied raw water to generate dialysis water. The dialysis water generated by the dialysis water generating device 2 is supplied to the dialysis fluid preparation device 3, which prepares the dialysis fluid. The dialysis fluid prepared by the dialysis fluid preparation device 3 is supplied to the hydrogen addition device 1, which adds hydrogen to the dialysis fluid, thereby generating the dialysis fluid in which hydrogen has been dissolved.

[0052] As in the hemodialysis system 100, the concentration of dissolved hydrogen is adjusted by the concentration adjusting device 4 and supplied to the dialysis device 5. This makes it possible to suppress fluctuations in the dissolved hydrogen concentration of the dialysis fluid. This makes it possible to perform dialysis treatment using a dialysis fluid with a dissolved hydrogen concentration that is appropriate for the patient's constitution and symptoms.

[0053] Fig. 5 is a block diagram of a hemodialysis system 100C which is yet another modification of the hemodialysis system 100 in Fig. 1. For parts of the hemodialysis system 100C that are not described below, the configurations of the above-mentioned hemodialysis systems 100, 100A, and 100B can be adopted.

[0054] The hemodialysis system 100C differs from the hemodialysis system 100 etc. in that it includes a sensor 6 that measures the dissolved hydrogen concentration of the dialysis fluid used by the dialysis device 5 and a control device 7 for controlling the concentration adjusting device 4.

[0055] The sensor 6 is disposed between the concentration adjusting device 4 and the dialysis device 5. The sensor 6 may be disposed inside the concentration adjusting device 4 or inside the dialysis device 5. The sensor 6 measures the dissolved hydrogen concentration of the dialysis fluid supplied to the dialysis device 5, and outputs an electrical signal corresponding to the measured dissolved hydrogen concentration to the control device 7.

[0056] The control device 7 has, for example, a CPU (Central Processing Unit) that executes various arithmetic processing, information processing, etc., and a memory that stores programs that control the operation of the CPU and various information. Various functions of the control device 7 are realized by the CPU, memory, and programs. The control device 7 and the control unit 16 may be provided with a CPU or the like that integrates the functions of both.

[0057] The control device 7 controls the concentration adjustment device 4 based on the electrical signal output from the sensor 6. When the dissolved hydrogen concentration of the dialysis fluid is lower than the target value, the control device 7 controls the concentration adjustment device 4 to increase the dissolved hydrogen concentration. When the dissolved hydrogen concentration of the dialysis fluid is higher than the target value, the control device 7 controls the concentration adjustment device 4 to decrease the dissolved hydrogen concentration. This makes it possible to easily suppress fluctuations in the dissolved hydrogen concentration of the dialysis fluid. This makes it easy to perform dialysis treatment using a dialysis fluid with a dissolved hydrogen concentration that suits the patient's constitution and symptoms.

[0058] Fig. 6 is a block diagram of a hemodialysis system 100D which is a modification of the hemodialysis system 100C in Fig. 5. For the parts of the hemodialysis system 100D which are not described below, the configuration of the hemodialysis system 100C described above can be adopted.

[0059] The hemodialysis system 100D differs from the hemodialysis system 100C in that it includes a plurality of dialysis machines 5. According to the hemodialysis system 100D, the plurality of dialysis machines 5 can be used to perform dialysis treatment for a plurality of patients simultaneously.

[0060] In the hemodialysis system 100D, in order to be able to supply dialysis fluid to a plurality of dialysis devices 5, it is desirable to provide, for example, a tank for storing dialysis water between the dialysis water generating device 2 and the dialysis fluid preparation device 3. The tank may be provided between the hydrogen addition device 1 and the dialysis water generating device 2 or between the dialysis fluid preparation device 3 and the concentration adjusting device 4.

[0061] Fig. 7 is a block diagram of a hemodialysis system 100E which is a modified example of the hemodialysis system 100D in Fig. 6. For parts of the hemodialysis system 100E that are not described below, the configuration of the hemodialysis system 100D described above can be adopted.

[0062] The hemodialysis system 100E differs from the hemodialysis system 100D in that it includes a concentration adjusting device 4 and a sensor 6 corresponding to each dialysis machine 5. That is, the hemodialysis system 100E includes a plurality of dialysis machines 5, a plurality of concentration adjusting devices 4, and a plurality of sensors 6.

[0063] Each concentration adjusting device 4 adjusts the dissolved hydrogen concentration of the dialysis fluid supplied to the associated dialysis device 5. Each sensor 6 measures the dissolved hydrogen concentration of the dialysis fluid supplied to the associated dialysis device 5. The measurement result of each sensor 6 is output to the control device 7 as an electrical signal.

[0064] The control device 7 individually controls the corresponding concentration adjusting device 4 based on the electrical signal output from each sensor 6. That is, the control device 7 controls the corresponding concentration adjusting device 4 so that the dissolved hydrogen concentration becomes a preset value for each dialysis device 5. Note that the control device 7 may be provided for each sensor 6.

[0065] In the hemodialysis system 100E, the dissolved hydrogen concentration of the dialysis fluid supplied to each dialysis machine 5 may be the same or may be different for each dialysis machine 5.

[0066] By controlling the dissolved hydrogen concentration of the dialysis fluid supplied to each dialysis device 5 to be the same, the dissolved hydrogen concentrations of all the dialysis fluids supplied simultaneously to multiple dialysis devices 5 are made uniform, making it possible to easily suppress fluctuations in the dissolved hydrogen concentration of the dialysis fluid for each dialysis device 5.

[0067] By controlling the dissolved hydrogen concentration of the dialysis fluid supplied to each dialysis machine 5 to be different for each dialysis machine 5, even when dialysis treatment is performed on multiple patients at the same time, it is easily possible to perform dialysis treatment using dialysis fluid with an individual dissolved hydrogen concentration according to the constitution and symptoms of each patient.

[0068] Fig. 8 is a block diagram of a hemodialysis system 100F which is another modified example of the hemodialysis system 100D in Fig. 6. For the parts of the hemodialysis system 100F that are not described below, the configuration of the above-mentioned hemodialysis system 100D, etc. can be adopted.

[0069] The hemodialysis system 100F differs from the hemodialysis system 100D in that it includes multiple different types of concentration adjustment devices 4A to 4D. The types of the multiple concentration adjustment devices 4A to 4D used in this hemodialysis system 100F include the above-mentioned device for increasing the dissolved hydrogen concentration of the dialysis fluid and the device for decreasing the dissolved hydrogen concentration of the dialysis fluid. The type of the concentration adjustment devices 4A to 4D is not particularly limited, but it is preferable that the concentration adjustment devices 4A to 4D include any of the above-mentioned devices for increasing the dissolved hydrogen concentration of the dialysis fluid and any of the devices for decreasing the dissolved hydrogen concentration of the dialysis fluid.

[0070] In the hemodialysis system 100F, the control device 7 selects and controls a concentration adjusting device to be operated from among a plurality of types of concentration adjusting devices 4A to 4D based on an electrical signal output from the sensor 6.

[0071] For example, when it is desired to rapidly increase the dissolved hydrogen concentration of the dialysis fluid, the control device 7 fully operates concentration adjustment devices 4A and 4B, which include an electrolytic cell 11 and a device that pressurizes hydrogen gas inside a cylinder or the like. On the other hand, when it is desired to rapidly decrease the dissolved hydrogen concentration of the dialysis fluid, the control device 7 fully operates concentration adjustment devices 4C and 4D, which degas hydrogen gas and a device that dilutes the dialysis fluid with hydrogen dissolved therein.

[0072] The different types of concentration adjusters 4A to 4D do not necessarily need to be arranged in a concentrated manner as shown in FIG. 8, but may be individually and dispersedly installed, for example, between the hydrogen addition device 1 and the dialysis water production device 2, or between the dialysis water production device 2 and the dialysis fluid preparation device 3. In addition, in the case of adopting the configuration of the hemodialysis systems 100A to 100E, each concentration adjuster 4 may be replaced with a different type of concentration adjuster 4A to 4D. Here, the installation location of each concentration adjuster 4A to 4D may be between the hydrogen addition device 1 and the sensor 6. In addition, the hydrogen addition device 1 may be configured to serve as a part of the concentration adjusters 4A to 4D, or a pressure reducing valve provided in at least one of the dialysis device 5, the dialysis fluid preparation device 3, and the dialysis water production device 2 may be configured to serve as a part of the concentration adjusters 4A to 4D.

[0073] Furthermore, when it is desired to control the dissolved hydrogen concentration of the dialysis fluid with high accuracy, the control device 7 operates the concentration adjustment device 4A including the electrolytic cell 11 that can control the amount of hydrogen gas generated by the electrolysis current. Furthermore, when it is desired to finely adjust the dissolved hydrogen concentration of the dialysis fluid, the control device 7 operates the concentration adjustment devices 4A, 4D including the electrolytic cell 11 and the one that dilutes the dialysis fluid with hydrogen dissolved therein.

[0074] In the hemodialysis system 100F, the control device 7 may be configured to determine a priority order for the operation of each of the concentration adjustment devices 4A to 4D based on the output from the sensor 6, and to control each of the concentration adjustment devices 4A to 4D based on the priority order.

[0075] The priority order of the operations of each of the concentration adjusting devices 4A to 4D is determined by using a learning model that has been generated in advance by deep learning using artificial intelligence (AI). The learning model is defined by an intermediate layer generated by machine learning, with the output from the sensor 6, i.e., the dissolved hydrogen concentration of the dialysis fluid, as an input layer, and the priority order of the operations of each of the concentration adjusting devices 4 as an output layer.

[0076] Although the hemodialysis system 100 and the like of the present invention have been described in detail above, the present invention is not limited to the above specific embodiments and may be modified and practiced in various forms.

[0077] For example, the hemodialysis systems 100 to 100F are preferably provided with an operating device (not shown) for arbitrarily operating the control device 7 or the concentration adjusting device 4. The operating device may be provided in at least one of the dialysis water generating device 2, the dialysis fluid preparing device 3, and the dialysis device 5 so that a doctor, a nurse, or the like can remotely or closely operate the control device 7 or the concentration adjusting device 4 from near the patient, etc. The operating device is composed of, for example, various buttons, a touch panel, etc., for the doctor, nurse, etc. to input operations.

[0078] [Note] The present invention includes the following aspects.

[0079] [Invention 1] 1. A hemodialysis system comprising: A dialysis water generating device that purifies the supplied water and generates dialysis water; a dialysis fluid preparation device for mixing a drug with the dialysis water to prepare a dialysis fluid to be used in hemodialysis treatment; a dialysis device for filtering the patient's blood using the dialysis fluid; A hydrogen addition device that adds hydrogen to at least one of the water supplied to the dialysis water generating device, the dialysis water generated by the dialysis water generating device, and the dialysis fluid prepared by the dialysis fluid preparation device; and a concentration adjusting device for adjusting the dissolved hydrogen concentration of the dialysis fluid used by the dialysis device. Hemodialysis system. [Invention 2] a sensor for measuring the dissolved hydrogen concentration of the dialysis fluid used by the dialysis device; A hemodialysis system as described in claim 1, further comprising a control device that controls the concentration adjustment device based on an output from the sensor. [Invention 3] A hemodialysis system according to claim 2, comprising a plurality of the dialysis machines. [Invention 4] A hemodialysis system as described in the present invention 3, comprising the concentration adjustment device and the sensor corresponding to each dialysis machine. [Invention 5] The hemodialysis system according to the present invention 4, wherein the control device controls the concentration adjustment device so as to equalize the dissolved hydrogen concentrations of all of the dialysis fluids supplied simultaneously to the plurality of dialysis devices. [Invention 6] The hemodialysis system according to the fourth aspect of the present invention, wherein the control device controls the concentration adjustment device so that the dialysis fluid supplied to each dialysis device has a different dissolved hydrogen concentration. [Invention 7] The hemodialysis system according to any one of claims 1 to 6, wherein the concentration adjusting device includes a plurality of types of concentration adjusting devices. [Invention 8] a sensor for measuring the dissolved hydrogen concentration of the dialysis fluid used by the dialysis device; A hemodialysis system as described in invention 7, further comprising a control device which determines a priority order for the operation of each concentration adjusting device based on the output from the sensor, and controls each concentration adjusting device based on the priority order. [The present invention 9] 9. A hemodialysis system according to any one of claims 1 to 8, wherein the hydrogen addition device includes an electrolytic cell that generates hydrogen gas by electrolyzing supplied water. [The present invention 10] 10. The hemodialysis system according to claim 9, wherein the electrolytic cell is also applicable as the concentration adjusting device. [The present invention 11] At least one of the dialysis water generating device, the dialysis fluid preparation device, and the dialysis device is provided with a pressure reducing valve for degassing hydrogen gas contained in the dialysis water or the dialysis fluid, 11. The hemodialysis system according to any one of claims 1 to 10, wherein the pressure reducing valve is also applicable as the concentration adjusting device. [The present invention 12] 12. The hemodialysis system according to any one of claims 1 to 11, wherein at least one of the dialysis water generating device, the dialysis fluid preparation device, and the dialysis device is provided with an operating device for arbitrarily operating the control device or the concentration adjusting device. [Explanation of symbols]

[0080] 1: Hydrogenation device 2: Dialysis water generator 3: Dialysate preparation device 4:Concentration adjustment device 5: Dialysis machine 6: Sensor 7: Control device 11: Electrolytic cell 100: Hemodialysis system 100A: Hemodialysis system 100B: Hemodialysis system 100C: Hemodialysis system 100D: Hemodialysis system 100E: Hemodialysis system 100F: Hemodialysis system

Claims

1. 1. A hemodialysis system comprising: A dialysis water generating device that purifies the supplied water and generates dialysis water; a dialysis fluid preparation device for mixing a drug with the dialysis water to prepare a dialysis fluid to be used in hemodialysis treatment; a dialysis device for filtering the patient's blood using the dialysis fluid; A hydrogen addition device that adds hydrogen to at least one of the water supplied to the dialysis water generating device, the dialysis water generated by the dialysis water generating device, and the dialysis fluid prepared by the dialysis fluid preparation device; a concentration adjusting device for adjusting the dissolved hydrogen concentration of the dialysis fluid used by the dialysis device, At least one of the dialysis water generating device, the dialysis fluid preparation device, and the dialysis device is provided with a pressure reducing valve for degassing hydrogen gas contained in the dialysis water or the dialysis fluid, The pressure reducing valve can also be used as the concentration adjusting device. Hemodialysis system.

2. a sensor for measuring the dissolved hydrogen concentration of the dialysis fluid used by the dialysis device; The hemodialysis system according to claim 1 , further comprising a control device that controls the concentration adjusting device based on an output from the sensor.

3. The hemodialysis system of claim 2 comprising a plurality of said dialysis machines.

4. The hemodialysis system according to claim 3 , further comprising the concentration adjusting device and the sensor corresponding to each dialysis machine.

5. The hemodialysis system according to claim 4 , wherein the control device controls the concentration adjusting device so as to equalize the dissolved hydrogen concentrations of all of the dialysis fluids simultaneously supplied to the plurality of dialysis devices.

6. The hemodialysis system according to claim 4 , wherein the control device controls the concentration adjustment device so that the dialysis fluid supplied to each of the dialysis devices has a different dissolved hydrogen concentration.

7. The hemodialysis system of claim 1 , wherein the concentration adjustment device includes a plurality of concentration adjustment devices.

8. The hemodialysis system described in claim 1, wherein the hydrogen addition device includes an electrolytic cell that generates hydrogen gas by electrolyzing supplied water.

9. A hemodialysis system as described in Claim 8, wherein the electrolytic cell is also applicable as the concentration adjustment device.

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