Disinfectants

Abstract

To provide a disinfectant that can be checked whether the disinfectant has been applied properly after its application.SOLUTION: A disinfectant contains a light emitter that emits light by UV irradiation.SELECTED DRAWING: None

Description

[Technical field]

[0001] The present invention relates to a disinfectant that can be used to disinfect hands and fingers. [Background technology]

[0002] In recent years, the use of disinfectants that can easily sterilize hands, tables, etc. has become widespread due to increased awareness of cleanliness, and their importance is also increasing from the perspective of preventing infection with viruses, etc. Various types of disinfectants having bactericidal properties have been proposed according to the purpose and application. For example, an antibacterial agent containing silica-coated zinc oxide and a thickening polymer (see Patent Document 1) has been proposed as a composition that adequately maintains the bactericidal power of zinc oxide while preventing the formation of agglomerates of zinc oxide particles. In addition, a hand sanitizer composition containing (A): ethanol and / or isopropanol, (B): carboxyvinyl polymer and / or acrylic acid-alkyl methacrylate copolymer, and (C): plate-shaped powder having an aspect ratio of 10 or more in specified proportions has been proposed as a hand sanitizer composition with excellent usability (see Patent Document 2). Also, a hand sanitizer composition containing (A): one or more components selected from ethanol and isopropanol, component (B): one or more components selected from carboxyvinyl polymer, acrylic acid-alkyl methacrylate copolymer, and salts thereof, component (C): water-insoluble powder, and component (D): glycerin in specified proportions has been proposed as a gel-type hand sanitizer composition that uses powder but reduces the occurrence of clogging of the dispenser nozzle (see Patent Document 3). In addition to sterilization and disinfection, methods of hygiene management have also been proposed. One proposed hygiene management system includes a judgment unit that applies detergent and a marker substance to an object, then photographs the cleaned object and judges whether or not cleaning of the object is complete based on the size of the area in which the marker substance is captured, and a processing unit that performs processing according to the judgment result (see Patent Document 4). [Prior art documents] [Patent documents]

[0003] [Patent Document 1] JP 2002-363018 A [Patent Document 2] JP 2010-163419 A [Patent Document 3] JP 2015-78171 A [Patent Document 4] JP 2016-186438 A Summary of the Invention [Problem to be solved by the invention]

[0004] As mentioned above, disinfectants used for disinfecting hands and fingers are not only excellent in sterilization and disinfection, but also in terms of usability and prevention of clogging of containers. However, it goes without saying that the most important thing for a disinfectant is to be able to perform sufficient sterilization and disinfection, and for that purpose, it is necessary to apply the disinfectant reliably. However, most disinfectants are transparent, and it is difficult to confirm whether the application has been performed reliably after application. To confirm, it is necessary to check the moment of application visually or with a monitoring system, but at large-scale events, it is not realistic to visually check the moment when the disinfectant is applied to all attendees, and the introduction of a monitoring system requires a large amount of cost. In order to prevent virus infection in places where many people gather, reliable sterilization and disinfection are essential, and a method for checking whether the disinfectant has been applied reliably without incurring time or cost is required.

[0005] In view of the above-mentioned current situation, the present invention has an object to provide a disinfectant that makes it possible to check after application whether the disinfectant has been applied reliably. [Means for solving the problem]

[0006] The inventors discovered that by incorporating an illuminant that emits light when irradiated with ultraviolet light into a disinfectant, it is possible to easily confirm whether or not the disinfectant has been applied by irradiating the object with ultraviolet light after application, and thus completed the present invention.

[0007] That is, the present invention relates to a disinfectant characterized by containing a luminous body that emits light when irradiated with ultraviolet light.

[0008] The disinfectant preferably contains at least one type of alcohol selected from the group consisting of ethanol, n-propanol, and isopropanol in an amount of 40% by mass or more of the entire disinfectant.

[0009] It is preferable that the disinfectant further contains at least one thickener selected from the group consisting of polyacrylic acid-based thickeners, cellulose-based thickeners, polyvinyl alcohol, alginic acid and its salts, carrageenan, xanthan gum, and guar gum.

[0010] The illuminant that emits light when irradiated with ultraviolet light is preferably fluorescent zinc oxide.

[0011] The disinfectant preferably contains a luminous body that emits light when irradiated with ultraviolet light in an amount of 1 to 20% by mass based on the entire disinfectant.

[0012] The above-mentioned illuminant that emits light when irradiated with ultraviolet light preferably has an average particle size of 0.5 to 10 μm.

[0013] The disinfectant preferably has a viscosity of 300 to 300,000 mPa·s. Effect of the Invention

[0014] The disinfectant of the present invention is a disinfectant that allows the area to be easily confirmed even after application and drying, and therefore can be suitably used not only for daily use, but also for disinfection in places where many people gather and where reliable disinfection is required, and in medical settings. [Brief description of the drawings]

[0015] [Figure 1] FIG. 2 is a diagram showing the disinfectant of Example 1 of the present invention applied to a hand and irradiated with ultraviolet light. DETAILED DESCRIPTION OF THE PREFERRED EMBODIMENTS

[0016] A preferred embodiment of the present invention will be described in detail below, but the present invention is not limited to the following description, and can be modified and applied as appropriate within the scope that does not change the gist of the present invention.

[0017] The disinfectant of the present invention contains a luminous body that emits light when irradiated with ultraviolet light. Since the luminous body remains at the applied area even after the disinfectant is applied to an object and dried, only the applied area of ​​the disinfectant emits light when the object is irradiated with ultraviolet light, making it easy to confirm the area where the disinfectant has been applied.

[0018] The disinfectant of the present invention preferably contains alcohol as a disinfecting component. The alcohol is not particularly limited, but is preferably one that volatilizes at 1 atm and at about room temperature, and is preferably at least one alcohol selected from the group consisting of ethanol, n-propanol, and isopropanol. More preferably, it is ethanol.

[0019] The disinfectant of the present invention preferably contains alcohol, which is a disinfecting component, in an amount of 40% by mass or more of the entire disinfectant. By containing alcohol in such a ratio, it is possible to exert a more sufficient bactericidal and disinfecting effect. The ratio of alcohol is more preferably 45% by mass or more of the entire disinfectant.

[0020] The illuminant contained in the disinfectant of the present invention is not particularly limited as long as it emits light when irradiated with ultraviolet light, and one or more of fluorescent zinc oxide, fluorescent magnesium titanate, etc. can be used. Among these, fluorescent zinc oxide is preferred. Since zinc oxide has antibacterial and antiviral properties, the use of fluorescent zinc oxide as the illuminant enhances the bactericidal and disinfecting action of the disinfectant, and furthermore, since it remains on the hands as a disinfectant component even after the alcohol evaporates, it can provide sustained antibacterial and antiviral effects. In addition, fluorescent zinc oxide is widely used as a cosmetic product, and is also preferred in terms of its high safety to the human body.

[0021] The fluorescent zinc oxide is zinc oxide that emits light when excited by ultraviolet light. Any zinc oxide having such properties may be used, but zinc oxide having oxygen defects obtained by reducing zinc oxide (ZnO) is preferred. Zinc oxide having such oxygen defects is Zn 1+z O or ZnO 1-x It is believed to be represented by the average composition formula: The method for producing fluorescent zinc oxide is not particularly limited. For example, the fluorescent zinc oxide can be produced by adding a sulfur-containing compound to an oxygen-containing zinc compound such as zinc oxide or zinc carbonate, and then calcining the mixture under a reducing atmosphere. An example of commercially available fluorescent zinc oxide is Lumate G manufactured by Sakai Chemical Industry Co., Ltd., which emits clear green light when irradiated with ultraviolet light.

[0022] The luminescent material contained in the disinfectant of the present invention preferably has an average particle size of 0.5 to 10 μm. When the average particle size of the luminescent material is in this range, the disinfectant has an excellent feel when used for disinfecting hands and fingers. When the disinfectant contains a thickener, the amount of white residue (twisting) generated by entanglement of the thickener and the luminescent material particles can be suppressed. Furthermore, when the average particle size is in this range, the precipitation of the luminescent material particles in the disinfectant can be suppressed. The average particle size of the luminescent material is more preferably 1 to 7 μm, and even more preferably 1.5 to 4 μm. The average particle size referred to here is the average primary particle size. The average particle size of the luminescent material can be measured by the method described in the Examples below.

[0023] The content of the luminous body in the disinfectant of the present invention is preferably 1 to 20% by mass of the entire disinfectant. At such a ratio, the disinfecting and sterilizing action of the disinfectant is not impaired, and the application site can be more easily confirmed when irradiated with ultraviolet light after application of the disinfectant. The content of the luminous body is more preferably 1.5 to 10% by mass, and even more preferably 2 to 7% by mass of the entire disinfectant.

[0024] The disinfectant of the present invention preferably further contains a thickener. By containing the thickener, the disinfectant becomes thicker, making it easier to apply the disinfectant to the entire object. In addition, the sedimentation of the luminous body in the disinfectant can be suppressed. The thickener contained in the disinfectant of the present invention is not particularly limited as long as it can thicken the disinfectant, but it is preferable to use at least one selected from the group consisting of polyacrylic acid-based thickeners, cellulose-based thickeners such as methylcellulose and hydroxyalkylcellulose, polyvinyl alcohol, alginic acid and its salts, carrageenan, xanthan gum, and guar gum, and two or more may be used in combination. These thickeners can fully exert a thickening effect even on disinfectants containing fluorescent zinc oxide as a luminous body. More preferred thickeners are polyacrylic acid-based thickeners and cellulose-based thickeners, and even more preferred are polyacrylic acid-based thickeners, hydroxypropylmethylcellulose, and hydroxyethylcellulose.

[0025] When the disinfectant of the present invention contains a thickener, the content of the thickener is preferably 0.2 to 10% by mass of the entire disinfectant. At such a ratio, the disinfectant can be thickened without impairing the sterilizing and disinfecting action of the disinfectant. The content of the thickener is more preferably 0.5 to 8% by mass, and even more preferably 1 to 5% by mass of the entire disinfectant.

[0026] The disinfectant of the present invention preferably has a viscosity of 300 to 300,000 mPa·s. When the disinfectant has such an appropriate viscosity, it becomes easy to apply the disinfectant to the entire object. The viscosity of the disinfectant is more preferably 1,000 to 200,000 mPa·s, and further preferably 2,000 to 100,000 mPa·s. By adjusting the viscosity, it is possible to provide a disinfectant in a gel, gel, sol, liquid, or other form. The viscosity of the disinfectant can be measured by the method described in the Examples below.

[0027] The disinfectant of the present invention preferably contains water in addition to the illuminant that emits light when irradiated with ultraviolet light, the disinfectant, and the thickener. By containing water, the disinfectant has a better feeling when used. The content of water is preferably 5 to 59% by mass of the entire disinfectant, more preferably 10 to 50% by mass, and further preferably 30 to 45% by mass.

[0028] The disinfectant of the present invention may contain other ingredients in addition to the above-mentioned ingredients, such as fragrances, preservatives, moisturizers, antibacterial agents, etc.

[0029] The content of the other components is preferably 2% by mass or less of the entire disinfectant, more preferably 1.5% by mass or less, and even more preferably 1% by mass or less.

[0030] The disinfectant of the present invention is not particularly limited to the object to be used, but if the particle size and viscosity of the luminous body are in a suitable range, it is easy to use for disinfecting hands and fingers, and has an excellent feel when used, so it can be suitably used for disinfecting hands and fingers. Therefore, one of the preferred embodiments of the present invention is that the disinfectant of the present invention is used as a disinfectant for hands and fingers. EXAMPLES

[0031] In order to explain the present invention in detail, specific examples are given below, but the present invention is not limited to these examples. Unless otherwise specified, "%" and "wt%" mean "weight % (mass %)".

[0032] Synthesis Example 1 (Synthesis of fluorescent zinc oxide) 20 g of zinc oxide (fine zinc oxide, manufactured by Sakai Chemical Industry Co., Ltd.), 0.0179 g of zinc sulfide (RAK-T, manufactured by Sakai Chemical Industry Co., Ltd.), and 0.0105 g of sodium bicarbonate (special grade, manufactured by Kanto Chemical Co., Ltd.) were weighed out and thoroughly dry-mixed for 30 minutes. The obtained raw material mixture powder was completely filled into an alumina crucible and mixed with 3% by volume H 2 / N 2The temperature was raised to 840°C at 150°C / hour in an atmosphere, held there for 2 hours, and then lowered at 150°C / hour. The fired product thus obtained was crushed in a mortar and the entire amount was loaded into an alumina crucible, after which the temperature was raised to 700°C at 150°C / hour in an air atmosphere, held there for 1 hour, and then cooled at 150°C / hour. The powder obtained was then washed with water and filtered. The cake obtained was dried overnight in a dryer at 130°C to obtain fluorescent zinc oxide. The D of this phosphor was 50 The wavelength was 2.7 μm and the internal quantum efficiency was 35%. The particle size of the fluorescent zinc oxide can be controlled by adjusting various conditions such as the raw material ratio, temperature conditions, and hydrogen concentration.

[0033] Examples 1, 2, 4 to 6, Comparative Examples 1 to 3 The disinfectant was prepared according to the following procedure. (1) Ethanol, water, and thickener 1 were placed in a 200 ml beaker in the amounts shown in Table 1, and mixed at room temperature at 1,000 rpm using a Homo Disper (Primix Corporation). (2) The mixture obtained in (1) was adjusted to pH 7.5 using a 10% NaOH aqueous solution, and mixed in a Homo Disper at 1000 rpm. (3) Zinc oxide powder was added to the gelled liquid (2) in the amounts shown in Table 1, and mixed with a homodisper at 4,500 rpm to prepare a disinfectant.

[0034] Example 3 The disinfectant was prepared according to the following procedure. (1) 0.5 g of thickener 2 was added to a small amount of water to make a suspension, to which 60 g of ethanol was gradually added while stirring at 1000 rpm. Then, 20 g of water was added and stirred until the mixture became transparent. (2) 10 g of zinc oxide powder was added to the gelled liquid (1) and mixed at 4,500 rpm with a homodisper to prepare a disinfectant.

[0035] Example 7 The disinfectant was prepared according to the following procedure. (1) Ethanol, water, and thickener 2 were placed in a 200 ml beaker in the amounts shown in Table 1, and mixed at room temperature at 1000 rpm using a Homo Disper (Primix Corporation). (2)(1) The mixture obtained above was added to a 200 ml beaker and thickener 1 in the amount shown in Table 1, and mixed at room temperature at 1000 rpm using a Homo Disper (Primix Corporation). (3) The mixture obtained in (2) was adjusted to pH 7.5 using a 10% NaOH aqueous solution, and mixed in a Homo Disper at 1000 rpm. (4) Zinc oxide powder was added to the gelled liquid (3) in the amounts shown in Table 1, and mixed with a homodisper at 4,500 rpm to prepare a disinfectant.

[0036] Example 8 The disinfectant was prepared according to the following procedure. (1) Ethanol, water, and thickener 3 were placed in a 200 ml beaker in the amounts shown in Table 1, and mixed at room temperature at 1000 rpm using a Homo Disper (Primix Corporation). (2)(1) The mixture obtained above was added to a 200 ml beaker and thickener 1 in the amount shown in Table 1, and mixed at room temperature at 1000 rpm using a Homo Disper (Primix Corporation). (3) The mixture obtained in (2) was adjusted to pH 7.5 using a 10% NaOH aqueous solution, and mixed in a Homo Disper at 1000 rpm. (4) Zinc oxide powder was added to the gelled liquid (3) in the amounts shown in Table 1, and mixed with a homodisper at 4,500 rpm to prepare a disinfectant.

[0037] Various evaluations were carried out by the following methods for the disinfectants of Examples 1 to 8 and Comparative Examples 1 to 3. The results are shown in Table 1. <Average particle size of zinc oxide> Measurement was performed using a Microtrac (laser diffraction / scattering method), and the particle size value at which the integrated value reached 50% on the number-based particle size distribution curve was taken as the average particle size. <Viscosity> A Brookfield viscometer was used to measure at 12 rpm using rotor #3. <Fluorescence> After applying the disinfectant to the back of the hand, the back of the hand was irradiated with an ultraviolet lamp. If the light was visible, it was marked as ◯, and if it was not visible, it was marked as ×. <Sensation> A usage test was conducted by 10 panelists, who were asked to rate the sensation of use (skin sensation when applying the disinfectant) on a scale of 1.0 to 5.0 in increments of 0.1. The average scores are as follows: 4.0~5.0 points ◎ 3.0~3.9 points 〇 2.0~2.9 points △ 1.0~1.9 points × <Twisting> The samples that did not produce white residue (twisting) due to friction when applied were rated as ◯, and the samples that did produce white residue were rated as ×. <Dispersion> The overall condition of the gel was observed 48 hours after preparation. Those that did not become non-uniform or had no particle settling were marked with an ◎, those that saw settling but redispersed were marked with an ◯, and those that saw settling without being redispersed were marked with an ×.

[0038] [Table 1] Thickener 1: Accurin 33A (Dow Chemical Company, 28% solids; acrylates copolymer, the remainder is water) In addition, thickener 1 is in a state where the active ingredient is dispersed in water, and the formulation shown in the table is the amount of active ingredient only, and the amount of water is the combined amount of water in the thickener and the amount of water added. Thickener 2: HEC Daicel SE900 (Daicel Finechem Co., Ltd.; hydroxyethyl cellulose) Thickener 3: Metolose 60SH-4000 (Shin-Etsu Chemical Co., Ltd.; hydroxypropyl methylcellulose) Zinc oxide 1: Zinc oxide JIS type 1 Zinc oxide 2: Zinc oxide LPZINC-2 manufactured by Sakai Chemical Industry Co., Ltd.

[0039] From the results in Table 1, the disinfectants of Examples 1 to 8 containing fluorescent zinc oxide emitted light when irradiated with ultraviolet light after application, making it possible to confirm the area where the disinfectants were applied. Furthermore, it was confirmed that the disinfectants of Examples 1 to 5, 7, and 8 containing a thickener also suppressed the settling of zinc oxide and had excellent dispersibility, and that the use of fluorescent zinc oxide with a specific particle size resulted in better feel and twisting properties.

Claims

1. A disinfectant comprising a luminous body having an average particle size of 1.5 to 10 μm that emits light when irradiated with ultraviolet light.

2. The disinfectant according to claim 1, characterized in that the disinfectant contains at least one alcohol selected from the group consisting of ethanol, n-propanol, and isopropanol in an amount of 40% by mass or more of the entire disinfectant.

3. The disinfectant according to claim 1 or 2, further comprising at least one thickener selected from the group consisting of polyacrylic acid-based thickeners, cellulose-based thickeners, polyvinyl alcohol, alginic acid and its salts, carrageenan, xanthan gum, and guar gum.

4. The disinfectant according to any one of claims 1 to 3, characterized in that the illuminant that emits light when irradiated with ultraviolet light is fluorescent zinc oxide.

5. The disinfectant according to any one of claims 1 to 4, characterized in that the disinfectant contains a luminous body that emits light when irradiated with ultraviolet light in an amount of 1 to 20 mass % based on the entire disinfectant.

6. 6. The disinfectant according to claim 1, having a viscosity of 300 to 300,000 mPa·s.

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