Information processing apparatus, information processing system, information processing method, and program

Abstract

[Problem] To provide an information processing device whereby it is possible to predict the timing of appearance of optic hyperesthesia-related symptoms in an optic hyperesthesia patient. [Solution] An information processing device, the information processing device comprising an acquisition unit that acquires environment data and a reference information set that includes one or more items of reference information selected from (a) through (l), and a generating unit that generates provision information to be provided to a prescribed terminal on the basis of the environment data and the reference information set. (a) Sunshine time before optic hyperesthesia-related symptoms appear; (b) Timing of optic hyperesthesia-related symptoms; (c) Grade of optic hyperesthesia-related symptoms; (d) PGIC score; (e) Skin pigmentation information; (f) Melanin density; (g) Protoporphyrin level in blood; (h) Type of medicine; (i) Prescribed dose of medicine; (j) Fitzpatrick skin type; (k) PGIS score; (l) Data obtained from PROMIS

Description

Technical Field

[0001] The present invention relates to an information processing apparatus, an information processing system, an information processing method, and a program.

Background Art

[0002] Photosensitivity is a general term for skin diseases that occur or worsen due to sunlight or ultraviolet exposure, and photosensitivity-related symptoms such as dermatitis appear with light irradiation that does not cause a reaction in healthy people.

[0003] There are few fundamental treatments for photosensitivity, and the mainstream method for avoiding or alleviating symptoms is to prevent skin exposure to sunlight. To prevent skin exposure to sunlight, for example, there is a technology for notifying users of weather information (for example, Patent Document 1, etc.).

Prior Art Documents

Patent Documents

[0004]

Patent Document 1

Summary of the Invention

Problems to be Solved by the Invention

[0005] Patients suffering from photosensitivity tend to avoid going out during the day for fear of the appearance of photosensitivity-related symptoms, and there is a desire to improve QOL (Quality of Life) by knowing in advance the timing when photosensitivity-related symptoms appear.

[0006] An object of the present invention is to provide an information processing apparatus capable of predicting the timing when photosensitivity-related symptoms appear in patients with photosensitivity.

Means for Solving the Problems

[0007] The main invention of the present invention for solving the above problems is An acquisition unit that acquires a reference information set including one or more pieces of reference information selected from the following (a) to (l), and environmental data A generation unit that generates provision information to be provided to a predetermined terminal based on the environmental data and the reference information set An information processing apparatus comprising the same (a) Sunshine duration until symptoms related to photosensitivity appear (b) Timing of symptoms related to photosensitivity (c) Grade of symptoms related to photosensitivity (d) PGIC (Patient Global Impression of Change) score (e) Skin pigmentation information (f) Melanin density (g) Amount of protoporphyrin in blood (h) Type of drug (i) Prescribed amount of drug (j) Fitzpatrick skin type (k) PGIS score (Patient Global Impression Severity) (l) Data obtained by PROMIS (Patient-Reported Outcomes Measurement Information System)

[0008] In addition, regarding the problems disclosed in the present application and the solutions thereto, they will be clarified by the embodiments of the invention and the drawings.

Effect of the Invention

[0009] According to the present invention, it is possible to provide an information processing apparatus capable of predicting the timing at which symptoms related to photosensitivity appear in a patient with photosensitivity.

Brief Description of the Drawings

[0010]

Figure 1

Figure 2

Figure 3

Figure 4

Figure 5

Figure 6

Figure 7

Figure 8

Mode for Carrying Out the Invention

[0011] The contents of the embodiments of the present invention will be listed and described. The present invention has, for example, the following configuration.

[0012] [Item 1] An acquisition unit that acquires a reference information set including one or more pieces of reference information selected from the following (a) to (l) and environmental data; A generation unit that generates provided information to be provided to a predetermined terminal based on the environmental data and the reference information set; An information processing device comprising: (a) Sunshine duration until symptoms related to photosensitivity appear (b) Timing of symptoms related to photosensitivity (c) Grade of symptoms related to photosensitivity (d) PGIC (Patient Global Impression of Change) score (e) Skin pigment information (f) Melanin density (g) Amount of protoporphyrin in blood (h) Type of drug (i) Prescribed amount of drug (j) Fitzpatrick skin type (k) PGIS score (Patient Global Impression Severity) (l) Data obtained by PROMIS (Patient-Reported Outcomes Measurement Information System) [Item 2] The information providing device according to item 1, wherein the provided information is information that promotes light shielding. [Item 3] The information providing device according to item 1 or 2, wherein the provided information is information regarding the assumed sunshine duration until the appearance of photosensitivity-related symptoms calculated from the reference information set. [Item 4] Further comprising an information providing unit, The generation unit generates information regarding the remaining time of the assumed sunshine duration, The information providing unit notifies the terminal of the remaining time of the assumed sunshine duration, the information providing device according to item 3. [Item 5] The information providing device according to any one of items 1 to 4, wherein the environmental data includes one or more selected from solar radiation amount data, sunlight wavelength data, and weather information. [Item 6] The information providing device according to any one of items 1 to 5, wherein one or more of the reference information selected from (a) to (l) is information obtained from a clinical trial information database. [Item 7] The information providing device according to claim 6, wherein the reference information set further includes self-reported information of patients in need of treatment for photosensitivity. [Item 8] The information providing device according to item 7, wherein the self-reported information includes one or more selected from the following (Ia) to (Im). (Ia) Self-reported information of patients in need of treatment for phototoxic dermatitis (Ib) Self-reported information of patients in need of treatment for photoallergic dermatitis (Ic) Self-reported information of patients in need of treatment for pellagra (Id) Self-reported information of patients in need of treatment for porphyria (Ie) Self-reported information of patients in need of treatment for xeroderma pigmentosum (If) Self-reported information of patients in need of treatment for cocaine syndrome (Ig) Self-reported information of patients in need of treatment for Bloom syndrome (Ih) Self-reported information of patients in need of treatment for vitiligo (Ii) Self-reported information of patients in need of treatment for phenylketonuria (Ij) Self-reported information of patients in need of treatment for hydroa vacciniforme (Ik) Self-reported information of patients in need of treatment for solar urticaria (Il) Self-reported information of patients in need of treatment for polymorphic light eruption (Im) Self-reported information of patients in need of treatment for chronic actinic dermatitis [Item 9] The information processing apparatus according to Item 8, wherein the self-reported information of patients in need of treatment for the porphyria (Id) includes one or more selected from the following (Ida) to (Idf). (Ida) Self-reported information of patients in need of treatment for erythropoietic protoporphyria (EPP) (Idb) Self-reported information of patients in need of treatment for X-linked porphyria (XLP) (Idc) Self-reported information of patients in need of treatment for congenital erythropoietic porphyria (CEP) (Idd) Self-reported information of patients in need of treatment for variegate porphyria (VP) (Ide) Self-reported information of patients in need of treatment for acute intermittent porphyria (AIP) (Idf) Self-reported information of patients in need of treatment for porphyria cutanea tarda (PCT) [Item 10] The information processing apparatus according to any one of Items 7 to 9, wherein the self-reported information is acquired from the patient terminal of the patient. [Item 11] The information processing apparatus according to any one of Items 7 to 10, wherein the reference information set is updated based on the self-reported information. [Item 12] The information providing unit provides the provided information to a terminal owned by the patient or a doctor terminal operable by a doctor, the information processing apparatus according to any one of Items 1 to 11. [Item 13] The acquisition unit acquires input information from the doctor terminal, the information processing apparatus according to Item 12. [Item 14] The acquisition unit acquires one or more data selected from (x) solar radiation amount, (y) intensity distribution of light spectrum, and (z) time of going out of the patient, the information processing apparatus according to any one of Items 1 to 13. [Item 15] An acquisition unit that acquires a reference information set including one or more reference information selected from the following (a) to (l) and environmental data; A generation unit that generates provided information to be provided to a predetermined terminal based on the environmental data and the reference information set; An information processing system comprising: (a) Sunshine duration until signs related to photosensitivity appear (b) Timing of signs related to photosensitivity (c) Grade of signs related to photosensitivity (d) PGIC (Patient Global Impression of Change) score (e) Skin pigment information (f) Melanin density (g) Amount of protoporphyrin in blood (h) Type of medicine (i) Prescribed amount of medicine (j) Fitzpatrick skin type (k) PGIS score (Patient Global Impression Severity) (l) Data obtained by PROMIS (Patient-Reported Outcomes Measurement Information System) [Item 16] An information processing method using a computer, A step of obtaining a reference information set including one or more pieces of reference information selected from the following (a) to (l), and environmental data A step of generating provision information to be provided to a predetermined terminal based on the environmental data and the reference information set An information processing method comprising the above (a) Sunshine duration until symptoms related to photosensitivity appear (b) Timing of symptoms related to photosensitivity (c) Grade of symptoms related to photosensitivity (d) PGIC (Patient Global Impression of Change) score (e) Skin pigment information (f) Melanin density (g) Amount of protoporphyrin in blood (h) Type of drug (i) Prescribed amount of drug (j) Fitzpatrick skin type (k) PGIS score (Patient Global Impression Severity) (l) Data obtained by PROMIS (Patient-Reported Outcomes Measurement Information System) [Item 17] A program for causing a computer to execute an information processing method, wherein the program causes the computer to execute, as the information processing method, A step of obtaining a reference information set including one or more pieces of reference information selected from the following (a) to (l), and environmental data A step of generating provision information to be provided to a predetermined terminal based on the environmental data and the reference information set A program for causing a computer to execute the above (a) Sunshine duration until symptoms related to photosensitivity appear (b) Timing of symptoms related to photosensitivity (c) Grade of symptoms related to photosensitivity (d) PGIC (Patient Global Impression of Change) score (e) Skin pigment information (f) Melanin density (g) Amount of protoporphyrin in blood (h) Type of drug (i) Dosage of drug (j) Fitzpatrick skin type (k) PGIS score (Patient Global Impression Severity) (l) Data obtained by PROMIS (Patient-Reported Outcomes Measurement Information System)

[0013] <Details of the embodiment> A specific example of the information processing apparatus 10 according to an embodiment of the present invention will be described with reference to the drawings.

[0014] In this embodiment, as described in "New Dermatology, 3rd Edition, by Hiroshi Shimizu, Nakayama Shoten, 2018", "photosensitivity" is synonymous with "photosensitive dermatitis" and means a general term for skin diseases that occur or worsen due to sunlight or ultraviolet exposure. Therefore, in this embodiment, photosensitivity can include all skin diseases that occur or worsen due to sunlight or ultraviolet exposure. For example, photosensitivity includes phototoxic dermatitis, photoallergic dermatitis, pellagra, porphyria, xeroderma pigmentosum, Cockayne syndrome, Bloom syndrome, vitiligo, phenylketonuria, vaccinia-like vesicular disease, solar urticaria, polymorphic light eruption, chronic actinic dermatitis, and the like.

[0015] "Porphyria", which is one of the symptoms of photosensitivity, is a disease caused by the accumulation of porphyrin or its precursors due to a decrease in the activity of heme metabolic enzymes. One of the symptoms is photosensitivity (sunburn, burn-like symptoms). For example, porphyrias include erythropoietic protoporphyria (EPP), X-linked protoporphyria (XLP), congenital erythropoietic porphyria (CEP), variegate porphyria (VP), acute intermittent porphyria (AIP), porphyria cutanea tarda (PCT), etc.

[0016] "Photosensitivity-related symptoms" mean a condition that occurs or worsens in photosensitive patients due to sunlight or ultraviolet exposure, and changes from precursor symptoms (burning sensation, stinging pain, itching or tingling) to pain after sunlight exposure. Therefore, in this embodiment, photosensitivity-related symptoms include both the above-mentioned precursor symptoms and pain.

[0017] <Configuration> FIG. 1 is a diagram showing an example of an information processing system 1 including an information processing apparatus 10 according to this embodiment. In this embodiment, the information processing apparatus 10 is communicably connected to a patient terminal 20 and a doctor terminal 30 owned by a patient via a network NW.

[0018] In this embodiment, the network NW is, for example, the Internet. The network NW is constructed by, for example, a public telephone line network, a mobile phone line network, a wireless communication network, Ethernet (registered trademark), etc.

[0019] The information processing device 10 is a terminal managed by a medical institution or an organization that provides medical information, and constitutes a part of the information providing system 1 by executing information processing via the network NW with the patient terminal 20 and the doctor terminal 30. The information processing device 10 may be, for example, a workstation, a general-purpose computer such as a personal computer, or may be logically realized by cloud computing. Such an information processing device 10 may have an application or the like that can communicate with the patient terminal 20 and the doctor terminal 30 installed thereon, or may have a browser installed for accessing a web service that enables such communication.

[0020] The patient terminal 20 executes information processing via the network NW with the information processing device 10 and the doctor terminal 30. The information processing device 10 may be, for example, a general-purpose computer such as a workstation or a personal computer, or may be a mobile communication device such as a smartphone. Further, the patient terminal 20 may be a wearable device worn by the patient himself / herself. Such a patient terminal 20 may have an application or the like that can communicate with the information processing device 10 and the doctor terminal 30 installed thereon, or may have a browser installed for accessing a web service that enables such communication.

[0021] The doctor terminal 30 is, for example, a terminal used by a doctor working at a medical institution such as a hospital to grasp the patient's condition, and executes information processing via the network NW with the information processing device 10 and the patient terminal 20. The doctor terminal 30 may be, for example, a general-purpose computer such as a workstation or a personal computer, or may be a mobile communication device such as a smartphone. Such a doctor terminal 30 may have an application or the like that can communicate with the information processing device 10 and the patient terminal 20 installed thereon, or may have a browser installed for accessing a web service that enables such communication.

[0022] <Hardware Configuration> FIG. 2 is a diagram showing a hardware configuration example of a computer that realizes the information processing apparatus 10 according to the present embodiment. The computer includes at least a control unit 11, a memory 12, a storage 13, a communication unit 14, an input / output unit 15, and the like. These are electrically connected to each other through a bus 16.

[0023] The control unit 11 is an arithmetic unit that controls the operation of the entire information processing apparatus 10, controls the transmission and reception of data between each element, and performs information processing necessary for the execution and authentication processing of applications. For example, the control unit 11 is a processor such as a CPU (Central Processing Unit), and executes programs stored in the storage 13 and developed in the memory 12 to perform each information processing.

[0024] The memory 12 includes a main memory composed of a volatile storage device such as a DRAM (Dynamic Random Access Memory), and an auxiliary memory composed of a non-volatile storage device such as a flash memory or an HDD (Hard Disc Drive). The memory 12 is used as a work area of the control unit 11, and stores a BIOS (Basic Input / Output System) executed at the time of startup of the information processing apparatus 10 and various setting information.

[0025] The storage 13 stores various programs such as application programs. A database storing data used for each process may be constructed in the storage 13.

[0026] The communication unit 14 connects the information processing apparatus 10 to a network. The communication unit 14 communicates with external devices directly or via a network access point by a method such as a wired LAN (Local Area Network), a wireless LAN, Wi-Fi (Wireless Fidelity, registered trademark), infrared communication, Bluetooth (registered trademark), short-range or non-contact communication.

[0027] The input / output unit 15 is, for example, an information input device such as a keyboard, a mouse, a touch panel, etc., and an output device such as a display.

[0028] The bus 16 is commonly connected to each of the above elements and transmits, for example, address signals, data signals, and various control signals.

[0029] In this embodiment, since the hardware configurations of terminals such as computers and smartphones that implement the patient terminal 20 and the doctor terminal 30 are the same as the example of the hardware configuration of the information processing apparatus 10 shown in FIG. 2, the description thereof is omitted.

[0030] <Software Configuration> FIG. 3 is a diagram showing an example of the software configuration of the information processing apparatus 10 according to this embodiment. The information processing apparatus 10 can include each functional unit of a data acquisition unit 101, an information generation unit 102, an information providing unit 103, a patient terminal notification unit 104, and a doctor terminal notification unit 105, and each storage unit of a patient information storage unit 111, an environmental data storage unit 112, a doctor input information storage unit 113, and a provided information storage unit 114.

[0031] Note that the data acquisition unit 101, the information generation unit 102, the information providing unit 103, the patient terminal notification unit 104, and the hospital terminal notification unit 105 are realized by the control unit 11 provided in the information processing apparatus 10 reading out the program stored in the storage 13 to the memory 12 and executing it. The patient information storage unit 111, the environmental data storage unit 112, the doctor input information storage unit 113, and the provided information storage unit 114 are realized as a part of the storage area provided by at least one of the memory 12 and the storage 13.

[0032] The patient information storage unit 111 stores the information of the patient acquired by the data acquisition unit 101. The patient information storage unit 111 includes, for example, patient basic information and a set of patient reference information. FIG. 4 is a configuration example of the patient information stored in the patient information storage unit 111. The patient information may be associated with a patient ID. The patient basic information may include information regarding attributes such as the patient's name, age, gender, address, occupation, place of origin, etc., information regarding medical history, past history, allergies, constitution (such as obesity, frailty, etc.), eating habits, drinking, smoking, exercise habits, and other information regarding lifestyle habits.

[0033] The set of patient reference information stored in the patient information storage unit 111 includes, for example, one or more pieces of patient reference information selected from the following (a) to (l). (a) Sunshine duration until signs related to photosensitivity appear (b) Timing of signs related to photosensitivity (c) Grade of signs related to photosensitivity (d) PGIC (Patient Global Impression of Change) score (e) Skin pigment information (f) Melanin density (g) Amount of protoporphyrin in blood (h) Type of medicine (i) Prescribed amount of medicine (j) Fitzpatrick skin type (k) PGIS score (Patient Global Impression Severity) (l) Data obtained by PROMIS (Patient-Reported Outcomes Measurement Information System)

[0034] These sets of reference information may be, for example, information obtained from a clinical trial information database (not shown) that stores data (trial data) obtained from a clinical trial conducted at a medical institution or the like, or may be self-reported information of patients in need of treatment for photosensitivity, such as erythropoietic protoporphyria (EPP) and / or X-linked porphyria (XLP).

[0035] When the reference information set is information obtained from a clinical trial information database, the reference information set may include, in addition to the above (a) to (l), the date on which the clinical trial was conducted and the data acquisition date. The self-reported information may be information directly input by the patient using the patient terminal 20 into the patient terminal 20. Further, the reference information set may be information obtained from a database (not shown) that stores information input by the doctor who examined the patient using the doctor terminal 30. These reference information sets may be updated based on the self-reported information.

[0036] (a) The "sun exposure time until the appearance of photosensitivity-related symptoms" is, for example, in past clinical trials, the sunlight or ultraviolet exposure time until the photosensitivity-related symptoms of patients with photosensitivity appear. For example, it is the time until the appearance of photosensitivity-related symptoms in a clinical trial of Compound A for patients with erythropoietic protoporphyria and X-linked porphyria. That is, Compound A was administered to adult male and female patients with erythropoietic protoporphyria and X-linked porphyria in a randomized double-blind clinical trial for 16 weeks, and the time until the first appearance of symptoms caused by light exposure, including not only direct sunlight but also indirect sunlight, between 1 hour after sunrise and 1 hour before sunset.

[0037] Here, Compound A is, for example, a cocrystal containing 1-{2-[(3S,4R)-1-{[(3R,4R)-1-cyclopentyl-3-fluoro-4-(4-methoxyphenyl)pyrrolidin-3-yl]carbonyl}-4-(methoxymethyl)pyrrolidin-3-yl]-5-(trifluoromethyl)phenyl}piperidine-4-carboxylic acid and phosphoric acid.

[0038] (b) The "timing of photosensitivity-related symptoms" refers to the number of photosensitivity-related symptoms recorded by patients with photosensitivity. For example, it means the number of photosensitivity-related symptom events recorded by patients during the 16-week evaluation period in a clinical trial of Compound A for patients with erythropoietic protoporphyria and X-linked porphyria.

[0039] (c) The "Grade of Photodermatitis-Related Symptoms" is a stepwise evaluation of the intensity (degree) and pattern of photodermatitis-related symptoms recorded by patients with photodermatitis, using numbers or the like. For example, pain is divided into 11 levels from 0 to 10, with 0 indicating no pain and 10 indicating the worst possible pain, and it is a question about the pain score.

[0040] (d) The "PGIC (Patient Global Impression of Change) Score" means the patient's health-related QOL. For example, it is the evaluation of the patient's health-related QOL in the clinical trial of Compound A for patients with erythropoietic protoporphyria and X-linked porphyria, and it is the degree of improvement in the overall physical and mental health status recorded by the patients themselves at the 16-week time point of the above clinical trial. For example, in a questionnaire for scoring the degree of improvement on a 7-point scale, the lowest score is 7 points indicating "significantly deteriorated", and the highest score is 1 point indicating "significantly improved".

[0041] (e) "Skin Pigmentation Information" means the skin pigmentation information of patients with photodermatitis.

[0042] (f) "Melanin Density" means the melanin density of the skin of patients with photodermatitis. For example, it is the melanin density measured using a spectrophotometer at 6 locations on the skin of the patient's forehead, left cheek, right inner upper arm, left inner outer arm, right side of the abdomen, and left side of the buttocks at the 16-week time point of the above clinical trial.

[0043] (g) "Amount of Protoporphyrin in Blood" means the amount of protoporphyrin in the blood of patients with photodermatitis. For example, it is the amount of protoporphyrin in the blood of patients with photodermatitis at the 16-week time point of the above clinical trial.

[0044] (h) "Type of Drug" means the type of drug administered to patients with photodermatitis. For example, it means the type of drug administered in the above clinical trial.

[0045] (i) The "prescribed dose of the drug" means the prescribed dose of the drug administered to a patient with photosensitivity. For example, it means the prescribed dose of the drug administered in the above clinical trial. Here, the medication period of the drug may be included.

[0046] (j) The "Fitzpatrick skin type" is a scale that classifies the color of human skin into six levels (type 1 to type 6) based on the sensitivity due to exposure to ultraviolet rays. In particular, it is a scale classified by the way of occurrence of "red sunburn" corresponding to burns that occur when exposed to ultraviolet rays and "black sunburn" due to the synthesis of melanin in the skin as a reaction to protect the body from subsequent ultraviolet rays. For example, it means the skin type of the skin in the above clinical trial.

[0047] (k) The "PGIS score (Patient Global Impression Severity)" is a comprehensive severity that may be used to evaluate the severity of a disease based on the patient's impression. For example, in a clinical trial, the score given by the subject for the overall severity is used for evaluation. The subject means an evaluation on a scale of 5 from "none" to "very severe" of the severity they felt.

[0048] (l) The "data obtained by PROMIS (Patient-Reported Outcomes Measurement Information System)" is data obtained from indicators for evaluating seven domains of physical function, anxiety, depression, fatigue, sleep disorder, ability to participate in social roles and activities, and impairment due to pain (including pain intensity). For example, in the above clinical trial, it means the change amount of the PROMIS score (total score and total score of each domain).

[0049] The above (a) to (l) may be updated based on self-reported information.

[0050] Self-reported information includes, for example, one or more selected from the following (Ia) to (Im). (Ia) Self-reported information of patients in need of treatment for phototoxic dermatitis (Ib) Self-reported information of patients in need of treatment for photoallergic dermatitis (Ic) Self-reported information of patients in need of treatment for pellagra (Id) Self-reported information of patients in need of treatment for porphyria (Ie) Self-reported information of patients in need of treatment for xeroderma pigmentosum (If) Self-reported information of patients in need of treatment for cocaine syndrome (Ig) Self-reported information of patients in need of treatment for Bloom syndrome (Ih) Self-reported information of patients in need of treatment for vitiligo (Ii) Self-reported information of patients in need of treatment for phenylketonuria (Ij) Self-reported information of patients in need of treatment for hydroa vacciniforme (Ik) Self-reported information of patients in need of treatment for solar urticaria (Il) Self-reported information of patients in need of treatment for polymorphic light eruption (Im) Self-reported information of patients in need of treatment for chronic actinic dermatitis

[0051] The self-reported information of patients in need of treatment for the above (Id) porphyria includes, for example, one or more selected from the following (Ida) to (Idf). (Ida) Self-reported information of patients in need of treatment for erythropoietic protoporphyria (EPP) (Idb) Self-reported information of patients in need of treatment for X-linked porphyria (XLP) (Idc) Self-reported information of patients in need of treatment for congenital erythropoietic porphyria (CEP) (Idd) Self-reported information of patients in need of treatment for variegate porphyria (VP) (Ide) Self-reported information of patients in need of treatment for acute intermittent porphyria (AIP) (Idf) Self-reported information of patients in need of treatment for porphyria cutanea tarda (PCT)

[0052] The self-reported information may be updated each time the self-reported information is obtained.

[0053] The set of reference information of the patient stored in the patient information storage unit 111 may include information on drugs other than photosensitivity, regular medications, etc., and in that case, the prescribed dosage may also be included. Further, an image of the skin taken using a camera or the like may be included.

[0054] The environmental data storage unit 112 stores data on the environment acquired by the data acquisition unit 101. FIG. 5 is a configuration example of the environmental data stored in the environmental data storage unit 112. The environmental data includes, for example, solar radiation amount data such as the amount of ultraviolet rays, sunlight wavelength data, and meteorological information, and may also include, among others, temperature, humidity, wind speed, etc. These pieces of information may be data automatically or manually acquired from a solar radiation measurement application or a sunlight measurement application installed in the information processing device 10, or data input by the patient to the patient terminal 20 may be acquired. When the patient terminal 20 is a wearable device terminal, the environmental data may be data directly acquired by the wearable device terminal. Also, it may be configured to automatically acquire the weather information of that area published by the Japan Meteorological Agency or the like. That is, the information processing device 10 may cooperate with publicly available information to automatically acquire and store information.

[0055] The doctor input information storage unit 113 stores doctor input information acquired from the doctor terminal 30. FIG. 6 is a configuration example of the doctor input information stored in the doctor input information storage unit 113. The doctor input information includes, for example, the patient's medical examination information, that is, the date and time of the patient's medical examination and information similar to (a) to (l) included in the above reference information set.

[0056] The provided information storage unit 114 stores the provided information generated based on the reference information set stored in the patient information storage unit 111 and the environmental data stored in the environmental data storage unit 112. FIG. 7 is a configuration example of the provided information stored in the provided information storage unit 114. The provided information includes, for example, information that promotes light shielding, the assumed sunshine duration until the onset of light allergy-related symptoms calculated from the reference information set, and the remaining time until the onset of light allergy-related symptoms.

[0057] The data acquisition unit 101 acquires a reference information set including one or more pieces of reference information selected from (a) to (l) and environmental data. The data acquisition unit 101 may obtain the reference information set including the above-mentioned reference information and environmental data from within the patient terminal 20 or the doctor terminal 30, or via another data server. Also, from an application installed in the information processing device 10, for example, information on the amount of solar radiation and the intensity distribution of the light spectrum, or information on the patient's going-out time may be acquired. Further, the data acquisition unit 101 may receive data regarding the patient's own reference information and environmental data, for example, from the patient's own input, or from the input of a person other than the patient, such as the patient's family or friends, and may receive the input of data from two or more persons. The information acquired by the data acquisition unit 101 is stored in the patient information storage unit 111, the environmental data storage unit 112, or the doctor input information storage unit 113, respectively.

[0058] The information generation unit 102 generates the provided information to be provided to a predetermined terminal based on the data acquired by the data acquisition unit 101. That is, based on the patient's reference information set including one or more pieces of reference information selected from (a) to (l) and the environmental data, information to be provided to the patient or the doctor is generated. The information to be provided to the patient includes, as described above, for example, information that promotes light shielding, the assumed sunshine duration until the onset of light allergy-related symptoms calculated from the reference information set, and the remaining time of the assumed sunshine duration. The generated information is transmitted to the patient terminal 20 or the doctor terminal 30 by the information providing unit 103. The information generated by the information generation unit 102 is stored in the provided information storage unit 114.

[0059] The information providing unit 103 provides the provided information generated by the information generating unit 102 to a predetermined terminal. The terminal to which the information providing unit 103 provides information may be the patient terminal 20 owned by the patient, the doctor terminal 30, or a terminal of a third party other than these.

[0060] The patient terminal notification unit 104 notifies, for example, a message prompting the patient to acquire reference information and environmental data at a preset timing. The timing may be set for each patient, and for example, intervals and time zones can be set such as notifying at a predetermined time every day or notifying once a week. Also, it may issue a warning based on the provided information notified by the information providing unit 103. For example, it may issue a warning indicating that there is a high possibility that signs related to photosensitivity will appear at the timing when the remaining time of the assumed sunshine duration becomes short, for example, when the remaining time cuts one hour.

[0061] The doctor terminal notification unit 105 notifies, for example, a message prompting confirmation of the provided information when the provided information of the patient is acquired from the information providing unit 103 at a preset timing. Also, for example, when a reservation for a medical examination is input from the patient terminal 20 and the reservation information is acquired via the information processing device 10, it may notify the reservation information.

[0062] <Flow of information processing> FIG. 8 is a diagram showing the flow of processing executed in the information processing device 10 according to Embodiment 1.

[0063] First, as a preprocessing of this processing, the data acquisition unit 101 of the information processing device 10 receives an input of information regarding a patient and stores the patient basic information in the patient information storage unit 111. If the patient information is already stored in the patient information storage unit 111, it is also possible to refer to the patient information necessary for the information processing according to this embodiment by receiving an input such as a patient ID.

[0064] Next, the data acquisition unit 101 acquires a reference information set including one or more pieces of reference information selected from the above (a) to (l) and environmental data (S101). The acquisition of these data may be to acquire data held by the patient terminal 20, the doctor terminal 30, or other servers, or may be automatically acquired by the information processing apparatus 10 in cooperation with publicly known information, or may be acquired by an installed application. For example, when acquiring solar radiation data or sunlight wavelength data, the corresponding application is launched to acquire the data.

[0065] The information generation unit 102 generates provision information to be provided to a predetermined terminal based on the data acquired by the data acquisition unit 101 (S102). That is, information to be provided to the patient, doctor, etc. is generated based on a patient's reference information set including one or more pieces of reference information selected from (a) to (l) and environmental data.

[0066] The information provision unit 103 provides the provision information generated by the information generation unit 102 to a predetermined terminal (S103). The terminal to which the information provision unit 103 provides information may be the patient terminal 20 owned by the patient, may be the doctor terminal 30, or may be a terminal of a third party other than these. The information provided to the patient terminal 20 is, for example, information that promotes light shielding, the assumed sunshine duration until signs related to sunlight hypersensitivity appear, and the remaining time until signs related to sunlight hypersensitivity appear.

[0067] In this way, in the information processing apparatus 10 of the present embodiment, the timing when signs related to sunlight hypersensitivity of a patient with sunlight hypersensitivity appear is predicted, and the result is provided to a predetermined terminal. As a result, the patient with sunlight hypersensitivity can know the timing when signs related to sunlight hypersensitivity appear by checking the provision information provided to the patient terminal 20, and can take measures such as performing light shielding or changing the going-out time so that signs related to sunlight hypersensitivity do not appear. Also, if there is remaining time until signs related to sunlight hypersensitivity appear, it is possible to go out without light shielding.

[0068] Therefore, according to the information processing apparatus 10 of the present embodiment, by knowing in advance the timing when symptoms related to photosensitivity appear in a patient with photosensitivity, the patient can adjust the going-out time without avoiding going out during the day unnecessarily for fear of the appearance of symptoms related to photosensitivity, thereby improving the QOL.

[0069] As described above, the present embodiment has been described. However, the above embodiment is for facilitating the understanding of the present invention and is not for limiting the interpretation of the present invention. The present invention can be changed and improved without departing from its gist, and equivalents thereof are also included in the present invention.

[0070] For example, in the present embodiment, for the sake of convenience of explanation, one information processing apparatus 10, one patient terminal 20, and one doctor terminal 30 are each illustrated. However, a plurality of patient terminals 20 and doctor terminals 30 can be connected to the information processing apparatus 10 via the network NW. Further, although the information processing apparatus 10 is assumed to be one computer, the present invention is not limited thereto, and a system may be configured by dispersing functional units and storage units among a plurality of computers. For example, each storage unit of the information processing apparatus 10 may be provided in a database server, and the information processing apparatus 10 may access the database server. Also, each functional unit can be dispersed and provided in a plurality of computers.

[0071] Further, the information processing apparatus 10 may be a patient terminal owned by a patient and may be configured to access a separately provided database server.

[0072] Furthermore, it may include configurations other than the functional units and components included in FIG. 3. Also, other steps may be added to the steps included in FIG. 8. For example, in S101, when acquiring an image of a patient in which a skin image is captured by a camera (not shown), an image acquisition application may be started to acquire the skin image. Also, in S101, the reference information set may be updated based on the self-reported information. Thereby, it becomes possible to more accurately predict the timing when symptoms related to photosensitivity appear in a patient with photosensitivity.

[0073] Also, in S103 or after S103, a warning may be issued to the patient terminal 20 based on the provided information. Further, an evaluation unit for evaluating the drug efficacy in the clinical trial may be provided based on the provided information, and the result may be notified to the doctor terminal 30. Also, based on the evaluation, it may be set to prompt the patient to visit the doctor. In that case, it may be configured to receive a reservation for the visit and notify the doctor terminal 30.

[0074] As described above, the preferred embodiments of the present disclosure have been described in detail with reference to the accompanying drawings. However, the technical scope of the present disclosure is not limited to such examples. It is obvious that those having ordinary knowledge in the technical field of the present disclosure can conceive various modification examples or correction examples within the scope of the technical idea described in the claims, and these are naturally understood to belong to the technical scope of the present disclosure.

[0075] Also, the effects described in this specification are merely illustrative or exemplary and not restrictive. That is, the technology according to the present disclosure may exhibit other effects that are obvious to those skilled in the art from the description of this specification, together with or instead of the above effects.

Description of Reference Numerals

[0076] 1 Information processing system 10 Information processing device 11 Control unit 12 Memory 13 Storage 14 Communication unit 15 Input / output unit 16 Bus 20 Patient terminal 30 Doctor terminal 101 Data acquisition unit 102 Information generation unit 103 Information providing unit 104 Patient terminal notification unit 105 Doctor terminal notification unit 111 Patient information storage unit 112 Environmental data storage unit 113 Physician Input Information Memory Unit 114 Provided Information Memory Unit NW Network

Claims

1. An acquisition unit that acquires a reference information set of a patient in need of treatment for photosensitivity, including one or more pieces of reference information selected from the following (a) to (l), and environmental data; A generation unit that generates provided information including information regarding an assumed sunshine duration until photosensitivity-related symptoms appear, based on the environmental data and the reference information set; An information providing unit that provides the provided information to a predetermined terminal, and One or more pieces of reference information selected from the following (a) to (l) are information acquired from a clinical trial information database, The reference information set including the reference information acquired from the clinical trial information database is updated based on the self-reported information of the patient, an information processing device. (a) Sunshine duration until photosensitivity-related symptoms appear (b) Timing of photosensitivity-related symptoms (c) Grade of photosensitivity-related symptoms (d) PGIC (Patient Global Impression of Change) score (e) Skin pigment information (f) Melanin density (g) Amount of protoporphyrin in blood (h) Type of drug (i) Prescribed amount of drug (j) Fitzpatrick skin type (k) PGIS score (Patient Global Impression Severity) (l) Data obtained by PROMIS (Patient-Reported Outcomes Measurement Information System)

2. The provided information is information that promotes shading, the information processing device according to claim 1.

3. The generation unit generates information regarding the remaining time of the assumed sunshine duration, The information providing unit notifies the terminal of the remaining time of the assumed sunshine duration. The information processing apparatus according to claim 1 or 2.

4. The environmental data includes one or more selected from solar radiation amount data, sunlight wavelength data, and weather information. The information processing apparatus according to any one of claims 1 to 3.

5. The self-reported information includes one or more selected from the following (Ia) to (Im). The information processing apparatus according to any one of claims 1 to 4. (Ia) Self-reported information of patients requiring treatment for phototoxic dermatitis (Ib) Self-reported information of patients requiring treatment for photoallergic dermatitis (Ic) Self-reported information of patients requiring treatment for pellagra (Id) Self-reported information of patients requiring treatment for porphyria (Ie) Self-reported information of patients requiring treatment for xeroderma pigmentosum (If) Self-reported information of patients requiring treatment for cocaine syndrome (Ig) Self-reported information of patients requiring treatment for Bloom syndrome (Ih) Self-reported information of patients requiring treatment for vitiligo (Ii) Self-reported information of patients requiring treatment for phenylketonuria (Ij) Self-reported information of patients requiring treatment for vaccinia-like vesicular disease (Ik) Self-reported information of patients requiring treatment for solar urticaria (Il) Self-reported information of patients requiring treatment for polymorphic light eruption (Im) Self-reported information of patients requiring treatment for chronic actinic dermatitis

6. The self-reported information of the patients requiring treatment for (Id) porphyria includes one or more selected from the following (Ida) to (Idf). The information processing apparatus according to claim 5. (Ida) Self-reported information of patients requiring treatment for erythropoietic protoporphyria (EPP) Self-reported information of patients in need of treatment for (Idb) X-linked porphyria (XLP) Self-reported information of patients in need of treatment for (Idc) congenital erythropoietic porphyria (CEP) Self-reported information of patients in need of treatment for (Idd) variegate porphyria (VP) Self-reported information of patients in need of treatment for (Ide) acute intermittent porphyria (AIP) Self-reported information of patients in need of treatment for (Idf) porphyria cutanea tarda (PCT)

7. The self-reported information is obtained from a terminal owned by the patient, and the information processing apparatus according to any one of claims 1 to 6.

8. The information providing unit provides the provided information to a terminal owned by the patient or a doctor terminal operable by a doctor, and the information processing apparatus according to any one of claims 1 to 7.

9. The acquisition unit acquires input information from the doctor terminal, and the information processing apparatus according to claim 8.

10. The acquisition unit acquires one or more data selected from (x) solar radiation dose, (y) intensity distribution of light spectrum, and (z) time of going out of the patient, and the information processing apparatus according to any one of claims 1 to 9.

11. An acquisition unit that acquires a reference information set of patients in need of treatment for photosensitivity including one or more reference information selected from the following (a) to (l), and environmental data; A generation unit that generates provided information including information on the assumed sunshine duration until photosensitivity-related symptoms appear based on the environmental data and the reference information set; An information providing unit that provides the provided information to a predetermined terminal, and One or more reference information selected from the following (a) to (l) is information acquired from a clinical trial information database, An information processing system, wherein the reference information set including the reference information obtained from the clinical trial information database is updated based on the self-reported information of the patient. (a) Sunshine duration until symptoms related to photosensitivity appear (b) Timing of symptoms related to photosensitivity (c) Grade of symptoms related to photosensitivity (d) PGIC (Patient Global Impression of Change) score (e) Skin pigmentation information (f) Melanin density (g) Amount of protoporphyrin in blood (h) Type of drug (i) Prescribed amount of drug (j) Fitzpatrick skin type (k) PGIS score (Patient Global Impression of Severity) (l) Data obtained by PROMIS (Patient-Reported Outcomes Measurement Information System)

12. A step of obtaining a reference information set of a patient in need of treatment for photosensitivity, including one or more reference information selected from the following (a) to (l), and environmental data; A step of generating provided information including information on the assumed sunshine duration until symptoms related to photosensitivity appear, based on the environmental data and the reference information set; A step of providing the provided information to a predetermined terminal, which is an information processing method executed by a computer, One or more reference information selected from the following (a) to (l) is information obtained from a clinical trial information database, An information processing method, wherein the reference information set including the reference information obtained from the clinical trial information database is updated based on the self-reported information of the patient. (a) Sunshine duration until symptoms related to photosensitivity appear (b) Timing of symptoms related to photosensitivity (c) Grade of symptoms related to photosensitivity (d) PGIC (Patient Global Impression of Change) score (e) Skin pigment information (f) Melanin density (g) Amount of protoporphyrin in blood (h) Type of drug (i) Dosage of drug (j) Fitzpatrick skin type (k) PGIS score (Patient Global Impression Severity) (l) Data obtained by PROMIS (Patient-Reported Outcomes Measurement Information System)

13. A program for causing a computer to execute an information processing method, The program, as the information processing method, A step of obtaining a reference information set of a patient in need of treatment for photosensitivity including one or more pieces of reference information selected from the following (a) to (l), and environmental data; A step of generating provided information including information on the assumed sunshine duration until symptoms related to photosensitivity appear, based on the environmental data and the reference information set; A step of causing a computer to execute a step of providing the provided information to a predetermined terminal, One or more pieces of reference information selected from the following (a) to (l) are information obtained from a clinical trial information database, The reference information set including the reference information obtained from the clinical trial information database is updated based on the self-reported information of the patient. Program. (a) Sunshine duration until symptoms related to photosensitivity appear (b) Timing of symptoms related to photosensitivity (c) Grade of symptoms related to photosensitivity (d) PGIC (Patient Global Impression of Change) score (e) Skin pigmentation information (f) Melanin density (g) Amount of protoporphyrin in blood (h) Type of drug (i) Prescribed amount of drug (j) Fitzpatrick skin type (k) PGIS score (Patient Global Impression Severity) (l) Data obtained by PROMIS (Patient-Reported Outcomes Measurement Information System)

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