Composition

Abstract

This composition is excellent in terms of moisturizing feeling, an absence of a squeaky feel, and ease of absorption.　The composition contains one or more of the following compounds (A) to (C): (A) tranexamic acid or salts thereof; (B) niacinamide; and (C) alkyl glycosides and stearic acid PEG esters.

Description

Technical Field

[0001] The present invention relates to a composition.

Background Art

[0002] The skin develops spots, wrinkles, sagging, pigmentation, etc. due to internal factors such as aging and stress, and external factors such as ultraviolet rays and dry air. Among these, morphological changes such as wrinkles and sagging greatly affect the external appearance, and many people hope for improvement. Many drugs have been proposed to prevent and improve these wrinkles and sagging. Among these, niacinamide is known to be highly safe and have an anti-skin-aging effect (see, for example, Patent Document 1).

[0003] On the other hand, tranexamic acid is known to have an anti-inflammatory effect and may be used for the purpose of obtaining a whitening effect. In recent years, it may be used in a composition for improving wrinkles (see, for example, Patent Document 2).

Prior Art Documents

Patent Documents

[0004]

Patent Document 1

Patent Document 2

Summary of the Invention

Problems to be Solved by the Invention

[0005] Niacinamide and tranexamic acid are also excellent in moisture retention, and a high moisture retention effect is expected by using them in combination in a composition. However, there may be a problem in usability such as a squeaking feeling or poor compatibility during use. Therefore, an object of the present invention is to develop a composition that has a moisturizing feeling on the back of the neck and is excellent in usability such as no squeaking feeling and good compatibility.

Means for Solving the Problems

[0006] In view of such circumstances, as a result of intensive studies, the present inventor has surprisingly found that by containing one or more selected from alkyl glucoside and stearic acid PEG ester, and niacinamide and tranexamic acid, a composition having no creaking feeling during use, good familiarity, and further improved moisturizing feeling on the back skin can be obtained, and thus the present invention has been completed.

[0007] That is, the present invention provides the following. [1] The following components (A) to (C); (A) Tranexamic acid or a salt thereof (B) Niacinamide (C) One or more selected from alkyl glucoside and stearic acid PEG ester A composition containing the same. [2] The composition according to [1], further containing component (D) dimethiconol. [3] The composition according to [2], wherein the mass ratio (B) / (D) of the component (B) to the component (D) is 2 to 12. [4] The composition according to any one of [1] to [3], further containing component (E) isostearic acid. [5] The composition according to any one of [1] to [4], wherein the mass ratio (A) / (C) of the component (A) to the component (C) is 1.5 to 6. [Advantages of the Invention]

[0008] According to the present invention, a composition excellent in moisturizing feeling, no creaking feeling, and good familiarity can be provided. [Embodiments for Carrying Out the Invention]

[0009] Hereinafter, the present invention will be described in detail. In this specification, "~" means a range including the numerical values before and after it.

[0010] Component (A) tranexamic acid or its salt used in the present invention is a kind of amino acid represented by the chemical name: trans-4-(aminomethyl)cyclohexane-1-carboxylic acid. In the present invention, it can be used in a salt state, and can be salts of inorganic bases such as sodium salt and potassium salt, or salts of organic bases such as triethanolamine and lysine.

[0011] The content of component (A) in the present invention is not particularly limited, but from the viewpoints of moisturizing feeling and non-scratchiness, 0.01 to 10% by mass (hereinafter, “% by mass” is represented as “%”) is preferable, 0.1 to 7% is more preferable, and 1 to 5% is even more preferable.

[0012] Component (B) niacinamide used in the present invention (also known as nicotinamide) is also called vitamin B3 and is a coenzyme deeply involved in various biochemical reactions in the living body such as energy metabolism and oxidation-reduction. It is said to have the effects of maintaining the skin and mucous membranes normally and promoting blood flow, and it is known that symptoms such as “pellagra (dermatitis, gastrointestinal disorders, neuropathy, etc.)” occur when it is deficient. In addition, niacinamide is a component that is formulated in cosmetics and topical skin preparations in expectation of improving the skin because it is water-soluble, stable to heat, acid, alkali or light, and has high safety.

[0013] The content of component (B) in the present invention is not particularly limited, but from the viewpoints of moisturizing feeling and good affinity, 0.1 to 10% is preferable, 1 to 8% is more preferable, and 2 to 7% is even more preferable.

[0014] Component (C) used in the present invention is one or more selected from alkyl glucoside and stearic acid PEG ester.

[0015] The alkyl glucoside of component (C) used in the present invention is a nonionic surfactant in which the alkyl group of the lipophilic group and the sugar of the hydrophilic group are linked by a glycosidic bond. The number of carbon atoms in the alkyl group is not particularly limited, but the lower limit is preferably 6 or more carbon atoms, more preferably 10 or more carbon atoms, and the upper limit is preferably 22 or less carbon atoms, more preferably 18 or less carbon atoms. The sugar is not particularly limited, and examples thereof include monosaccharides, disaccharides, oligosaccharides, and polysaccharides such as glucose, fructose, galactose, xylose, maltose, sucrose, lactose, lactulose, sucrose, fructose, starch, and dextrin. Monosaccharides are preferred, and glucose is more preferably used. More specifically, for example, hexyl glucoside, caprylyl glucoside, capryl glucoside, nonyl glucoside, decyl glucoside, lauryl glucoside, myristyl glucoside, hexadecyl glucoside, octadecyl glucoside, cetearyl glucoside, coconut oil alkyl glucoside, etc., and alkyl glucosides (carbon number: 8-16), alkyl glucosides (carbon number: 12-20), etc., which are mixtures of these, can be mentioned. These may be used alone or in combination of two or more.

[0016] The stearic acid PEG ester of component (C) used in the present invention is a nonionic surfactant obtained by addition polymerization of stearic acid, which is a fatty acid, and ethylene oxide. Stearic acid may be branched or linear. The number of moles of ethylene oxide added is not particularly limited, but is about 2 to 300 moles, preferably 10 or more, more preferably 30 or more as the lower limit, and preferably 200 moles or less, more preferably 150 moles or less as the upper limit. More specifically, for example, stearic acid PEG-2 (hereinafter, the number of moles of addition polymerization of ethylene oxide is indicated by the number after PEG-), stearic acid PEG-3, stearic acid PEG-10, stearic acid PEG-20, stearic acid PEG-30, stearic acid PEG-40, stearic acid PEG-45, stearic acid PEG-55, stearic acid PEG-100, stearic acid PEG-200, etc. can be mentioned. These may be used alone or in combination of two or more.

[0017] Component (C) in the present invention is one or more selected from alkyl glucoside and PEG stearate. From the viewpoints of moisturizing feeling and good familiarity, it is preferable that component (C) contains both alkyl glucoside and PEG stearate.

[0018] The content of component (C) in the present invention is not particularly limited, but from the viewpoints of moisturizing feeling and no harsh feeling, 0.1 to 5% is preferable, and 0.2 to 3% is more preferable.

[0019] The mass ratio (A) / (C) of the component (A) to the component (C) is not particularly limited, but from the viewpoints of moisturizing feeling and no harsh feeling, 1 to 10 is preferable, 1.5 to 6 is more preferable, and 2 to 5 is even more preferable.

[0020] The present invention can further contain component (D) dimethiconol. From the viewpoints of moisturizing feeling and no harsh feeling, it is preferable that the present invention further contains component (D). Component (D) dimethiconol used in the present invention is dimethicone modified by a hydroxyl group and having no crosslinked structure. Among them, it is preferable that the modified sites are at both ends because a smooth feeling peculiar to silicone compounds can be effectively obtained. Further, from the viewpoints of moisturizing feeling and no harsh feeling, it is preferable that the viscosity of component (D) at 25°C is 100,000 mPa·s or more, more preferably 500,000 mPa·s to 30,000,000 mPa·s, and even more preferably 1,000,000 mPa·s to 20,000,000 mPa·s.

[0021] Incidentally, the viscosity of component (D) can be calculated as follows. Prepare a toluene solution of dimethiconol at a concentration of 1 g / 100 mL, and determine the specific viscosity ηsp (25 °C) according to the following formula (1). Next, substitute it into the Huggins relational formula shown in the following formula (2) to obtain the intrinsic viscosity [η]. Further, substitute [η] into the A. Kolorlov formula shown in the following formula (3) to obtain the molecular weight M. Finally, substitute M into the A. J. Barry formula shown in the following formula (4) to obtain the viscosity η of dimethiconol. ηsp = (η / η0) - 1 ··· (1) (However, η0: the viscosity of toluene, η: the viscosity of the solution, are measured in accordance with the first method of the viscosity measurement method in the general test method for cosmetic raw materials standards.) ηsp = [η] + K'[η] 2 (2) (However, K': the Huggins constant uses the one described in Nakamura, Nippon Kasei Kagaku, 77 588

[1956] .) [η] = 0.215×10 -4 M 0.65 (3) logη = 1.00 + 0.0123M 0.5 (4)

[0022] The content of component (D) in the present invention is not particularly limited, but from the viewpoints of moisturizing feeling and no squeaking feeling, 0.1 to 8% is preferable, and 0.2 to 6% is more preferable.

[0023] The mass ratio (B) / (D) of the component (B) to the component (D) is not particularly limited, but from the viewpoints of moisturizing feeling and no squeaking feeling, 1.2 to 20 is preferable, 2 to 12 is more preferable, and 3 to 9 is even more preferable.

[0024] The present invention can further contain component (E) isostearic acid. From the viewpoints of moisturizing feeling and no squeaking feeling, it is preferable that the present invention further contains component (E). Component (E) isostearic acid used in the present invention is a saturated side-chain fatty acid having 18 carbon atoms, and is not particularly limited as long as it is usually used in cosmetics. For example, it can be obtained by purifying 2-heptylundecanoic acid obtained by the Garbett method, 2-isooctylisoundecanoic acid obtained by the aldol condensation method, or the side-chain fatty acid having 18 carbon atoms by-produced during the production of dimer acid.

[0025] The content of component (E) in the present invention is not particularly limited, but from the viewpoints of moisturizing feeling and no squeaking feeling, 0.1 to 10% is preferable, and 0.2 to 7% is more preferable.

[0026] In addition to the above components, the composition of the present invention can contain optional components as long as the effects of the present invention are not impaired. For example, it can contain powders, aqueous components, water-soluble polymers, film-forming agents, coloring agents, preservatives, antibacterial agents, ultraviolet absorbers, fragrances, antioxidants, pH adjusters, chelating agents, beauty components, etc. other than components (A) to (C).

[0027] The production method of the composition of the present invention can be produced without particular limitation as long as it is a known mixing and preparation method. For example, dispersion mixing, solubilization, high-pressure emulsification treatment method, etc. can be mentioned.

[0028] The dosage form of the composition of the present invention is not particularly limited, and examples include aqueous type, oil-in-water type, water-in-oil type, oil type, etc., and the oil-in-water type is preferable from the viewpoint of no squeaking feeling. Further, the composition of the present invention can be implemented in various forms such as liquid, gel, paste, cream, solid, etc.

[0029] The composition of the present invention can be used, for example, as pharmaceuticals, external skin preparations, cosmetics, foods, etc.

[0030] The composition of the present invention can be applied as a topical skin preparation. For example, topical liquid preparations, topical gel preparations, cream preparations, ointment preparations, liniment preparations, lotion preparations, pack preparations, plaster preparations, spray preparations, aerosol preparations, etc. can be mentioned. Also, the method of use can be mentioned in the same way as the cosmetics described later.

[0031] Moreover, the composition of the present invention can be applied as a cosmetic. For example, skin care cosmetics such as lotion, emulsion, cream, eye cream, beauty liquid, massage agent, pack agent, hand cream, body milk, body cream, hair styling agent, sunscreen cosmetics, etc., hair cosmetics such as shampoo, conditioner, hair cream, etc., cleansing cosmetics such as body soap, hand soap, face wash, cleansing agent, etc., makeup cosmetics such as lipstick, powder foundation, liquid foundation, cream foundation, concealer, face powder, makeup base, blusher, eyeshadow, mascara, eyeliner, eyebrow, etc. can be exemplified, and the method of use includes methods using hands, cotton, puffs, etc., methods of applying to non-woven fabrics, etc. and using, methods of spraying from a spray container, etc.

Examples

[0032] Examples are given below to explain the present invention in more detail, but the present invention is not limited thereto.

[0033] Examples 1 to 24, Comparative Examples 1 to 4: Cosmetic compositions The compositions having the compositions shown in Tables 1 and 2 were adjusted by the following production method, evaluated and judged according to the following evaluation method and judgment criteria, and the results are shown in Tables 1 and 2 together.

[0034]

Table 1

[0035]

Table 2

[0036] (Production method: Table 1) A: Uniformly mix and dissolve Components 1, 2, and 12. B: Uniformly mix and dissolve Components 3 to 11, and heat to 70°C. C: Add A to B and mix uniformly. D: Fill into a container to obtain a cosmetic composition. (Manufacturing method: Table 2) A: Uniformly mix and dissolve Components 1, 2, and 10. B: Uniformly mix and dissolve Components 3 to 9, and heat to 70°C. C: Add A to B and mix uniformly. D: Fill into a container to obtain a cosmetic composition.

[0037] (Evaluation items) I. Moisturizing feeling II. Absence of squeaking feeling III. Good familiarity

[0038] (Evaluation method) Five professional panelists who had received training in the sensory evaluation of cosmetics and were able to evaluate according to certain criteria were selected from women in their 20s to 40s. Each sample was used around the cheeks. For I. Moisturizing feeling, they were asked whether they felt the moisturizing feeling (if they felt the moisturizing feeling, they were to answer good; if they didn't feel it, they were to answer bad). For II. Absence of squeaking feeling, they were asked whether they felt the absence of squeaking feeling (if they didn't feel the squeaking feeling, they were to answer good; if they felt it, they were to answer bad). For III. Good familiarity, they were asked whether they felt the good familiarity (if they felt the good familiarity, they were to answer good; if they didn't feel it, they were to answer bad), and the results were answered and judged according to the following judgment criteria.

[0039] (Judgment criteria) (Judgment): (Evaluation) A: Five or more people answered good. B: Three or four people answered good. C: One or two people answered good. D: All people answered bad.

[0040] As is clear from the results in Table 1, Examples 1 to 24 were superior to the Comparative Examples in terms of all of the moisturizing feeling, lack of a squeaky feeling, and good familiarity. On the other hand, Comparative Example 1 that did not contain Component (A) may not have been excellent in terms of the moisturizing feeling, lack of a squeaky feeling, and good familiarity. Comparative Example 2 that did not contain Component (B) may not have been excellent in terms of the moisturizing feeling, lack of a squeaky feeling, and good familiarity. Comparative Examples 3 and 4 that did not contain Component (C) may not have been excellent in terms of the moisturizing feeling, lack of a squeaky feeling, and good familiarity.

[0041] Example 25: Oil-in-water type emulsifying cream (Component) (%) 1. 1,3-Butylene glycol 12.0 2. Glycerin 5.0 3. Purified water Balance 4. Niacinamide 4.0 5. Sodium N-stearoyl-N-methyltaurine 0.5 6. Stearic acid PEG-40 1.0 7. Tranexamic acid 4.0 8. α-Olefin oligomer 5.0 9. Heavy liquid isoparaffin (※4) 3.0 10. Dimethylpolysiloxane (10CS) 1.0 11. Ceramide 2 0.1 12. Astaxanthin 0.1 13. Tocopherol 0.01 14. Cetostearyl alcohol 2.0 15. Behenyl alcohol 1.0 16. Methyl paraoxybenzoate 0.1 17. Acrylic acid·alkyl methacrylate copolymer 0.15 18. Xanthan gum 0.1 19. 2% sodium hydroxide solution 0.2 20. Fragrance 0.1 (※4) Pearl Rim 18 (manufactured by NOF Corporation)

[0042] (Manufacturing method) A: Dissolve and mix Components 1 to 7 uniformly at 70°C. B: Dissolve and mix Components 8 to 16 uniformly at 80°C. C: Add B to A and emulsify at 70°C. D: Add and mix Components 17 to 20 to C, then cool to 40°C to obtain an oil-in-water type emulsified cream.

[0043] The oil-in-water type emulsified cream of Example 25 was excellent in all aspects of moisturizing feeling, non-grittiness, and good affinity.

[0044] Example 26: Oil-in-water type emulsified beauty liquid (Components) (%) 1. 1,3-Butylene glycol 5.0 2. Tranexamic acid 1.0 3. Purified water balance 4. Niacinamide 3.5 5. Decyl glucoside 0.85 6. Phytosteryl macadamiate (※5) 1.0 7. Light liquid isoparaffin (※6) 2.0 8. Dimethylpolysiloxane (6CS) 3.0 9. Ceramide 3 0.1 10. Tocopherol 0.01 11. Cetearyl alcohol 0.5 12. Methyl paraben 0.1 13. Carbomer 0.15 14. (Sodium acrylate / sodium acryloyldimethyltaurate) copolymer (※7) 0.1 15. Sodium hydroxide 2% solution 0.2 16. Ethanol 5.0 17. Fragrance 0.1 (※5) PLANDOOL-MAS (manufactured by Nippon Seika Co., Ltd.) (※6) Cholastane LES (manufactured by Croda) (※7) SIMULGEL EG (manufactured by SEPIC)

[0045] (Manufacturing method) A: Dissolve and mix Components 1 to 5 uniformly at 70°C. B: Dissolve and mix Components 5 to 12 uniformly at 80°C. C: Add B to A and emulsify at 70°C. D: After adding and mixing Components 13 to 17 to C, cool to 40°C to obtain an oil-in-water type emulsified beauty liquid.

[0046] The oil-in-water type emulsified beauty liquid of Example 26 was excellent in all aspects of moisturizing feeling, lack of roughness, and good familiarity.

Claims

1. The following components (A) to (C); (A) Tranexamic acid or a salt thereof (B) Niacinamide (C) One or more selected from alkyl glucoside and PEG stearate containing Further, a composition containing 0.2 to 10% by mass of component (E) isostearic acid.

2. The composition according to claim 1, further containing component (D) dimethiconol.

3. The composition according to claim 2, wherein the mass ratio (B) / (D) of the component (B) to the component (D) is 2 to 12.

4. The composition according to any one of claims 1 to 3, wherein the mass ratio (A) / (C) of the component (A) to the component (C) is 1.5 to 6.

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