Nicotine Gel

Abstract

To provide a gel composition comprising an alkaloid compound, such as nicotine, or a cannabinoid compound, such as cannabidiol or tetrahydrocannabinol, with improved physical stability.SOLUTION: A gel composition includes: an alkaloid compound or a cannabinoid compound, or both an alkaloid compound and a cannabinoid compound; glycerol; a viscosifying agent; a hydrogen-bond crosslinking gelling agent; an ionic crosslinking gelling agent; and an acid.SELECTED DRAWING: Figure 1

Description

Technical Field

[0001] The present disclosure relates to an alkaloid or cannabinoid gel that can be used with an aerosol generating device. In some aspects, the present disclosure relates to a nicotine gel that can be used with an aerosol generating device.

Background Art

[0002] Nicotine compositions for use with aerosol generating articles are known. The nicotine composition is often a liquid composition such as an e-liquid that is heated by a coiled electrical resistive filament of the aerosol generating article. Considerable care is taken to manufacture a container for holding this liquid composition to avoid accidental leakage of the liquid composition. Accidental leakage can occur especially when the container is made of paper, cardboard, or any material that can be absorbed or damaged by the liquid nicotine composition.

[0003] The use of alternative forms of nicotine-containing compositions can reduce concerns about the possibility of leakage. However, these alternative forms of nicotine-containing compositions can undergo a phase change from gel to liquid over time. In particular, a nicotine-containing composition in gel form may release a liquid phase during storage or from manufacture until consumption by the user. This is particularly true for gel compositions containing high levels of glycerol, low levels of water, or both high levels of glycerol and low levels of water.

[0004] It is desirable to provide a gel composition comprising an alkaloid compound such as nicotine, or a cannabinoid compound such as cannabidiol or tetrahydrocannabinol, having enhanced physical stability. It is desirable to provide a gel composition comprising an alkaloid compound such as nicotine, or a cannabinoid compound such as cannabidiol or tetrahydrocannabinol, which may have enhanced physical stability. It is desirable to provide a gel composition comprising an alkaloid compound such as nicotine, or a cannabinoid compound such as cannabidiol or tetrahydrocannabinol, that does not release a liquid phase over a wide range of storage conditions. It is desirable to provide a gel composition comprising an alkaloid compound such as nicotine, or a cannabinoid compound such as cannabidiol or tetrahydrocannabinol, that does not absorb a liquid phase. It is desirable to provide a gel composition in which an alkaloid compound such as nicotine, or a cannabinoid compound such as cannabidiol or tetrahydrocannabinol, vaporizes within the composition upon heating. It is desirable to provide a gel composition comprising an alkaloid compound such as nicotine, or a cannabinoid compound such as cannabidiol or tetrahydrocannabinol, that does not leak from an aerosol generating device. SUMMARY OF THE INVENTION

[0005] Various aspects of the present disclosure relate to gel compositions comprising an alkaloid compound, or a cannabinoid compound, or both an alkaloid compound and a cannabinoid compound. Various aspects of the present disclosure relate to gel compositions comprising nicotine. These gel compositions may not release or absorb water over a wide range of relative humidities (such as, for example, from about 10% to about 60% relative humidity). The gel composition comprises an alkaloid compound, or a cannabinoid compound, or both an alkaloid compound and a cannabinoid compound, glycerol, a hydrogen-bond crosslinking gelling agent, an ionic crosslinking gelling agent, a thickening agent, and an acid.

[0006] The gel composition may contain an alkaloid compound, or a cannabinoid compound, or both an alkaloid compound and a cannabinoid compound, at least about 50 wt% glycerol or at least 70 wt% glycerol, at least about 0.2 wt% of a hydrogen-bond crosslinked gelling agent, at least about 0.2 wt% of an ionic crosslinked gelling agent, at least about 0.2 wt% of a thickening agent, and an acid.

[0007] The gel composition may contain nicotine, at least about 50 wt% glycerol or at least 70 wt% glycerol, at least about 0.2 wt% of a hydrogen-bond crosslinked gelling agent, at least about 0.2 wt% of an ionic crosslinked gelling agent, at least about 0.2 wt% of a thickening agent, and an acid.

[0008] The gel composition may contain a thickening agent, a hydrogen-bond crosslinked gelling agent, and an ionic crosslinked gelling agent in a total amount of about 1 wt% to about 8 wt%.

[0009] The gel composition may contain about 0.5 wt% to about 2 wt% of a thickening agent. The gel composition may contain about 0.5 wt% to about 2 wt% of a hydrogen-bond crosslinked gelling agent. The gel composition may contain about 0.5 wt% to about 2 wt% of an ionic crosslinked gelling agent. The gel composition may contain about 0.5 wt% to about 2 wt% of a thickening agent, about 0.5 wt% to about 2 wt% of a hydrogen-bond crosslinked gelling agent, and about 0.5 wt% to about 2 wt% of an ionic crosslinked gelling agent. Each of the thickening agent, the hydrogen-bond crosslinked gelling agent, and the ionic crosslinked gelling agent may be present in substantially equal amounts in the gel composition.

[0010] The gel composition may contain an alkaloid compound in an amount of about 0.5 wt% to 2.5 wt%, or a cannabinoid compound in an amount of about 0.5 wt% to 2.5 wt%, or both an alkaloid compound and a cannabinoid compound with a total amount of about 0.5 wt% to 2.5 wt%, about 70 wt% to 80 wt% of glycerol, about 0.5 wt% to 2 wt% of a hydrogen-bond crosslinked gelling agent, about 0.5 wt% to 2 wt% of an ionic crosslinked gelling agent, about 0.5 wt% to 2 wt% of a thickening agent, about 15 wt% to about 25 wt% of water, a divalent cation, and an acid. Each of the thickening agent, the hydrogen-bond crosslinked gelling agent, and the ionic crosslinked gelling agent may be present in substantially equal amounts in the gel composition.

[0011] The gel composition may contain nicotine in an amount of about 0.5 wt% to 2.5 wt%, about 70 wt% to 80 wt% of glycerol, about 0.5 wt% to 2 wt% of a hydrogen-bond crosslinked gelling agent, about 0.5 wt% to 2 wt% of an ionic crosslinked gelling agent, about 0.5 wt% to 2 wt% of a thickening agent, about 15 wt% to about 25 wt% of water, a divalent cation, and an acid. Each of the thickening agent, the hydrogen-bond crosslinked gelling agent, and the ionic crosslinked gelling agent may be present in substantially equal amounts in the gel composition.

[0012] The gel composition may contain an alkaloid compound in an amount of about 1.5 wt% to 2.5 wt%, or a cannabinoid compound in an amount of about 1.5 wt% to 2.5 wt%, or both an alkaloid compound and a cannabinoid compound with a total amount of about 1.5 wt% to 2.5 wt%, about 70 wt% to about 75 wt% of glycerol, about 18 wt% to about 22 wt% of water, agar, xanthan gum, and low acyl gellan each in an amount of about 0.5 wt% to about 2 wt%, calcium ions, and a carboxylic acid such as lactic acid. Each of xanthan gum, agar, and low acyl gellan may be present in substantially equal amounts in the gel composition.

[0013] The gel composition may contain about 1.5 wt% to about 2.5 wt% nicotine, about 70 wt% to about 75 wt% glycerol, about 18 wt% to about 22 wt% water, about 0.5 wt% to about 2 wt% each of agar, xanthan gum, and low acyl gellan, calcium ions, and carboxylic acids such as lactic acid. Each of xanthan gum, agar, and low acyl gellan may be present in substantially equal amounts in the gel composition.

[0014] The gel composition may contain a gelling agent that forms a solid medium, glycerol dispersed in the solid medium, and an alkaloid compound, or a cannabinoid compound, or both an alkaloid compound and a cannabinoid compound dispersed in the glycerol. The composition forms a stable gel phase.

[0015] The gel composition may contain a gelling agent that forms a solid medium, glycerol dispersed in the solid medium, and nicotine dispersed in the glycerol. The composition forms a stable gel phase.

[0016] The gel composition may contain at least two gelling agents that form a solid medium, glycerol dispersed in the solid medium, and an alkaloid compound, or a cannabinoid compound, or both an alkaloid compound and a cannabinoid compound dispersed in the glycerol. The composition forms a stable gel phase.

[0017] The gel composition may contain at least two gelling agents that form a solid medium, glycerol dispersed in the solid medium, and nicotine dispersed in the glycerol. The composition forms a stable gel phase.

[0018] The gel composition may contain a thickening agent and a gelling agent that form a solid medium, glycerol dispersed in the solid medium, and an alkaloid compound, or a cannabinoid compound, or both an alkaloid compound and a cannabinoid compound dispersed in the glycerol. The composition forms a stable gel phase.

[0019] The gel composition may include a thickening agent and a gelling agent that form a solid medium, glycerol dispersed in the solid medium, and nicotine dispersed in the glycerol. The composition forms a stable gel phase.

[0020] The gel composition may include a thickening agent and at least two gelling agents that form a solid medium, glycerol dispersed in the solid medium, and an alkaloid compound, or a cannabinoid compound, or both an alkaloid compound and a cannabinoid compound dispersed in the glycerol. The composition forms a stable gel phase.

[0021] The gel composition may include a thickening agent and at least two gelling agents that form a solid medium, glycerol dispersed in the solid medium, and nicotine dispersed in the glycerol. The composition forms a stable gel phase.

[0022] A further aspect of the present disclosure may relate to the use of the composition by heating to vaporize an alkaloid compound, or a cannabinoid compound, or both an alkaloid compound and a cannabinoid compound, and to the use of a composition that does not release a liquid phase from the composition upon heating.

[0023] A further aspect of the present disclosure may relate to the use of the composition by heating to vaporize nicotine, and to the use of a composition that does not release a liquid phase from the composition upon heating.

[0024] Advantageously, the gel is solid at room temperature. In this context, "solid" means that the gel has a stable size and shape and does not flow. In this context, room temperature means 25 degrees Celsius. The gel can be defined as a substantially diluted cross-linked system that does not exhibit fluidity in the steady state. By weight, gels can be mostly liquid, and they exhibit solid-like behavior due to a three-dimensional cross-linked network within the liquid. It is the cross-linking within the fluid that gives the gel its structure (hardness). Thus, a gel can be a dispersion of liquid molecules within a solid in which liquid particles are dispersed in a solid medium.

[0025] Preferably, the gel composition has a viscosity of from 1,000,000 to about 1 Pascal per second, preferably from 100,000 to 10 Pascals, preferably from 10,000 to 1,000 Pascals per second, or from 1,000 to 100 Pascals per second, or from 500 to 200 Pascals per second, in order to impart the desired viscosity. The viscosity of the gel composition is measured at 25 °C at a shear rate of 1 s -1 and can be measured by measuring the viscosity of the sample using an Anton Paar MCR 302 rheometer with a parallel plate PP25 equipped with a P-PTD200 + H-PTD200 measurement cell.

[0026] The mass of the gel composition may not change by more than about 20%, or may not change by more than about 15%, or may not change by more than about 10% when exposed to various environmental storage conditions. The composition may have an external shape with an exposed surface area that does not change by more than about 10%, or more than about 5%, or more than about 1% when exposed to various environmental conditions.

[0027] In one or more embodiments, the gel composition has a mass and, at 24 degrees Celsius and 1 atmosphere, at a relative humidity in the range of about 10% to about 60%, or under typical storage conditions, its mass does not change by more than about 20%, or more than about 15%, or more than about 10%.

[0028] In one or more embodiments, the gel composition has an external shape with an exposed surface area that does not change by more than about 10%, or more than about 5%, or more than about 1% when exposed to a relative humidity in the range of about 10% to about 60% at 24 degrees Celsius and 1 atmosphere.

[0029] In one or more embodiments, the gel composition has an exposed surface area value (m 2 ) and a mass value (kg), and the mass value versus the exposed surface area value ranges from about 0.05:1 to about 1:1, or from about 0.1:1 to about 1:1, or from about 0.5:1 to about 1:0.1, or from about 0.5:1 to about 1:0.5.

[0030] Advantageously, the gel composition provides a predictable composition form during storage or during transport from manufacture to the consumer. A gel composition containing an alkaloid compound, or a cannabinoid compound, or both an alkaloid compound and a cannabinoid compound substantially maintains its shape. A gel composition containing an alkaloid compound, or a cannabinoid compound, or both an alkaloid compound and a cannabinoid compound does not release a liquid phase during storage or during transport from manufacture to the consumer. A gel composition containing nicotine substantially maintains its shape. A gel composition containing nicotine does not substantially release a liquid phase during storage or during transport from manufacture to the consumer. The gel composition can provide a simple consumable design. This consumable need not be designed to contain a liquid, and thus a wider range of materials and container structures can be contemplated.

[0031] The gel composition described herein can be combined with an aerosol generating device to provide an alkaloid compound aerosol to the lungs at an inhalation volume or air flow rate within the range of inhalation volumes or air flow rates of conventional smoking methods. The aerosol generating device can continuously heat the gel composition. The consumer can take a plurality of inhalations or "puffs" where each "puff" delivers an amount of the alkaloid compound aerosol. The gel composition can deliver a high alkaloid compound / total particulate matter (TPM) aerosol to the consumer upon heating, preferably in a continuous manner.

[0032] The gel composition described herein can be combined with an aerosol generating device to provide a nicotine aerosol to the lungs at an inhalation volume or air flow rate within the range of inhalation volumes or air flow rates of conventional smoking methods. The aerosol generating device can continuously heat the gel composition. The consumer can take a plurality of inhalations or "puffs" where each "puff" delivers an amount of the nicotine aerosol. The gel composition can deliver a high nicotine / total particulate matter (TPM) aerosol to the consumer upon heating, preferably in a continuous manner.

[0033] The gel compositions described herein can be combined with an aerosol generating device and provide a cannabinoid compound aerosol to the lungs at an inhalation volume or air flow rate within the range of inhalation volumes or air flow rates of conventional smoking methods. The aerosol generating device can continuously heat the gel composition. A consumer can take a plurality of inhalations or "puffs" where each "puff" delivers an amount of the cannabinoid compound aerosol. The gel composition can deliver a high cannabinoid compound / total particulate matter (TPM) aerosol to the consumer upon heating, preferably in a continuous manner.

[0034] The gel composition contains an alkaloid compound, or a cannabinoid compound, or both an alkaloid compound and a cannabinoid compound. The gel composition can contain one or more alkaloids. The gel composition can contain one or more cannabinoids. The gel composition can contain a combination of one or more alkaloids and one or more cannabinoids.

[0035] The term "alkaloid compound" means any one or more classes of naturally occurring organic compounds containing one or more basic nitrogen atoms. Generally, alkaloids contain at least one nitrogen atom in an amine-type structure. This nitrogen atom or another nitrogen atom in the molecule of an alkaloid compound can be active as a base in an acid-base reaction. Most alkaloid compounds have one or more of their nitrogen atoms as part of a cyclic system, such as a heterocyclic ring. In nature, alkaloid compounds are mainly found in plants, and are particularly common in certain families of flowering plants. However, some alkaloid compounds are found in animal species and fungi. In the present disclosure, the term "alkaloid compound" refers to both naturally occurring alkaloid compounds and synthetically made alkaloid compounds.

[0036] The gel composition preferably contains an alkaloid compound selected from the group consisting of nicotine, anatabine, and combinations thereof.

[0037] Preferably, the gel composition contains nicotine.

[0038] The term "nicotine" refers to nicotine and nicotine derivatives (e.g., free base nicotine, nicotine salts, and the like).

[0039] The term "cannabinoid compound" means any one type of natural compound found in parts of the cannabis plants Cannabis sativa, Cannabis indica, and Cannabis ruderalis. Cannabinoid compounds are particularly concentrated in the female flower heads. Naturally occurring cannabinoid compounds in the cannabis plant include cannabidiol (CBD) and tetrahydrocannabinol (THC). In the present disclosure, the term "cannabinoid compound" is used to describe both naturally derived cannabinoid compounds and synthetically produced cannabinoid compounds.

[0040] The gel may contain a cannabinoid compound selected from the group consisting of cannabidiol (CBD), tetrahydrocannabinol (THC), tetrahydrocannabinolic acid (THCA), cannabidiolic acid (CBDA), cannabinol (CBN), cannabigerol (CBG), cannabichromene (CBC), cannabicyclol (CBL), cannabivarin (CBV), tetrahydrocannabivarin (THCV), cannabidivarin (CBDV), cannabichromevarin (CBCV), cannabigerovarin (CBGV), cannabigerol monomethyl ether (CBGM), cannabinergic acid (CBE), cannabicitran (CBT), and combinations thereof.

[0041] The gel composition may preferably contain a cannabinoid compound selected from the group consisting of cannabidiol (CBD), THC (tetrahydrocannabinol), and combinations thereof.

[0042] The gel preferably contains cannabidiol (CBD).

[0043] The gel composition may contain nicotine and cannabidiol (CBD).

[0044] The gel composition may contain nicotine, cannabidiol (CBD), and THC (tetrahydrocannabinol).

[0045] The term "stable gel phase" or "stable gel" refers to a gel that substantially maintains its shape and mass when exposed to various environmental conditions. A stable gel cannot substantially release or absorb water (sweat) when exposed to standard temperature and pressure while varying the relative humidity from about 10% to about 60%. For example, a stable gel can substantially maintain its shape and mass when exposed to standard temperature and pressure while varying the relative humidity from about 10% to about 60%.

[0046] The term "thickening agent" refers to a compound that increases the viscosity without causing gel formation and maintains or preserves the mixture as a fluid when homogeneously added in an amount of 0.3 wt% to a 50 wt% water / 50 wt% glycerol mixture at 25°C. Preferably, the thickening agent, when homogeneously added in an amount of 0.3 wt% to a 50 wt% water / 50 wt% glycerol mixture at 25°C, -1 at a shear rate of 0.1 s, increases the viscosity by at least 50 cPs, preferably at least 200 cPs, preferably at least 500 cPs, preferably at least 1000 cPs without causing gel formation and maintains or preserves the mixture as a fluid. Preferably, the thickening agent, when homogeneously added in an amount of 0.3 wt% to a 50 wt% water / 50 wt% glycerol mixture at 25°C, -1 at a shear rate of 0.1 s, increases the viscosity by at least 2 times, at least 5 times, at least 10 times, or at least 100 times greater than before addition without causing gel formation and maintains or preserves the mixture as a fluid.

[0047] The viscosity values listed in this specification can be measured using a Brookfield RVT viscometer, while rotating a disk type RV#2 spindle at a speed of 6 revolutions per minute (rpm) at 25°C.

[0048] The term "gelator" refers to a compound that, when added in an amount of about 0.3% by weight to a homogeneous mixture of 50% by weight water / 50% by weight glycerol, forms a solid medium or support matrix and leads to a gel. Gelators include, but are not limited to, hydrogen bond cross-linked gelators and ionic cross-linked gelators.

[0049] The term "gel" refers to a solid at room temperature. In this context, "solid" means that the gel has a stable size and shape and does not flow. In this context, room temperature means 25 degrees Celsius. A gel can be defined as a substantially diluted cross-linked system that does not exhibit fluidity in the steady state. By weight, gels can be mostly liquid, and they exhibit solid-like behavior due to a three-dimensional cross-linked network within the liquid. It is the cross-linking within the fluid that gives the gel its structure (hardness). Thus, a gel can be a dispersion of liquid molecules within a solid in which liquid particles are dispersed in a solid medium.

[0050] The term "hydrogen bond cross-linked gelator" refers to a gelator that forms non-covalent cross-linking bonds or physical cross-linking bonds via hydrogen bonds. A hydrogen bond is not a covalent bond to a hydrogen atom but is a type of intermolecular electrostatic dipole-dipole interaction. It results from the attractive force between a hydrogen atom covalently bonded to an extremely electronegative atom such as an N, O, or F atom and another extremely electronegative atom.

[0051] The term "ionic cross-linked gelator" refers to a gelator that forms non-covalent cross-linking bonds or physical cross-linking bonds via ionic bonds. Ionic cross-linking involves the association of polymer chains by non-covalent interactions. When polyvalent molecules with opposite charges are electrostatically attracted to each other and generate a cross-linked polymer network, the cross-linked network is formed.

[0052] The gel compositions described herein can be combined with an aerosol generating device to deliver an alkaloid compound, or a cannabinoid compound, or both an alkaloid compound and a cannabinoid compound to a consumer. The gel compositions described herein can be combined with an aerosol generating device to deliver nicotine to a consumer. The gel composition may be packaged independently (as a gel consumable) from a portion of the aerosol generating device or may not form a portion of the aerosol generating device. A used-up gel consumable can be replaced with a fully filled gel consumable within the aerosol generating device. A plurality of these gel consumables can be combined with an aerosol generating device to form a kit.

[0053] The gel compositions described herein can be packaged in a sealed or closed container for transport from manufacture to consumer consumption. The gel composition has an exposed surface that contacts a headspace defined by the inner surface of the container. The headspace can have a relative humidity that equilibrates with the gel composition. The headspace relative humidity can be substantially similar to the (local) humidity provided by the gel composition.

[0054] The gel compositions described herein can be packaged or contained within an aerosol generating article. The term "aerosol generating article" is used to describe an article that can generate or emit an aerosol. The aerosol generating article can define a tubular element formed of a fluid-permeable material such as paper, cardboard, cotton, cellulose acetate, viscose, polylactic acid, or combinations thereof. The tubular element can include a wrapper. The wrapper can be formed from a fluid-permeable material such as paper, cardboard, cotton, or combinations thereof.

[0055] "Tubular element" describes a component suitable for use in an aerosol-generating article. Ideally, the tubular element is longer in the longitudinal direction than in width, but this is not necessarily required as it can be part of a plurality of component items where the longitudinal length becomes longer than the width. Typically, the tubular element is cylindrical, but this is not necessarily the case. For example, the tubular element can have an elliptical, polygonal such as triangular or rectangular, or irregular cross-section.

[0056] An aerosol-generating article can have an open end, a proximal end, and a distal end, which may be open or closed in different specific embodiments. The tubular element contains a gel composition and is preferably disposed in proximity to the distal end of the aerosol-generating article. By applying a negative pressure to the open proximal end, at least one of an alkaloid compound and a cannabinoid compound is released from the gel composition. The aerosol-generating article defines at least one opening between the proximal end and the distal end. The at least one opening defines at least one fluid inlet, such that when a negative pressure is applied to the open proximal end of the aerosol-generating article, for example, air enters the aerosol-generating article through the opening. Fluid, such as ambient air, drawn into the aerosol-generating article through the opening flows along the outer longitudinal axis passage of the fluid guide towards the gel composition near the distal end of the aerosol-generating article. Thereafter, the fluid flows through the inner longitudinal axis passage of the fluid guide from the distal end to the proximal end and out of the aerosol-generating article at the open proximal end.

[0057] By separating the opening from the distal end of the aerosol-generating article, the opening is separated from the tubular element containing the gel composition, reducing the likelihood of leakage of the gel composition through the opening. Further, by providing a passage, such as an outer major axis direction passage, for the airflow from the opening to the tubular element containing the gel composition, the fluid from the opening can be directed towards the gel composition, and the fluid guide can serve as an additional barrier between the gel composition and the opening. The advantage of this is to further reduce the likelihood of leakage of the gel composition through the opening. In addition, the inner major axis direction passage of the fluid guide provides a passage through which fluids, such as air and materials or vapors generated or released from the tubular element, are drawn out of the aerosol-generating article through the open proximal end.

[0058] Preferably, the aerosol-generating article is substantially cylindrical. This allows for a smooth flow of the aerosol. The aerosol-generating article can have an outer diameter of, for example, 4 millimeters to 15 millimeters, 5 millimeters to 10 millimeters, or 6 millimeters to 8 millimeters. The aerosol-generating article can have a length of, for example, 10 millimeters to 60 millimeters, 15 millimeters to 50 millimeters, or 20 millimeters to 45 millimeters.

[0059] The draw resistance (RTD) of the aerosol-generating article varies depending, inter alia, on the length and dimensions of the passage, the size of the opening, the dimensions of the narrowest cross-sectional area of the inner passage, and the materials used. In certain embodiments, the RTD of the aerosol-generating article is 50 millimeters of water column (mm H2O) and 140 millimeters of water column (mm H2O), 60 millimeters of water column (mm H2O) to 120 millimeters of water column (mm H2O), or 80 millimeters of water column (mm H2O) to 100 millimeters of water column (mm H2O). The RTD of the article refers to the static pressure difference between one or more openings of the article and the mouth-side end when the volume flow rate is 17.5 milliliters per second at the mouth-side end under stable conditions and is traversed by the inner major axis direction passage. The RTD of the specimen can be measured using the method described in ISO standard 6565:2002.

[0060] In certain embodiments, the aerosol-generating article comprises a plastic material, a metal material, a cellulose-based material such as cellulose acetate, paper, cardboard, cotton, or a combination thereof.

[0061] In certain embodiments, the fluid guide comprises a plastic material, a metal material, a cellulose-based material such as cellulose acetate, paper, cardboard, or a combination thereof.

[0062] In combination with certain embodiments, the wrapper comprises a plurality of materials. In certain embodiments, the wrapper, or a portion thereof, comprises a metal material, a plastic material, cardboard, cotton, or a combination thereof. When the wrapper comprises cardboard or paper, the openings can be formed by laser cutting.

[0063] The wrapper provides strength and structural rigidity for the aerosol-generating article. When paper or cardboard is used for the wrapper and high rigidity is desired, it is preferably to have a basis weight of more than 60 grams per square meter. One such wrapper provides high structural rigidity. The wrapper, if present, can resist deformation outside the aerosol-generating article at locations where the restrictor is embedded within the aerosol-generating article or at other locations such as cavities (if any) with weak structural support. In some embodiments, the tubular element wrapper comprises a metal layer. The metal layer can be used to concentrate the energy applied from the outside to heat the tubular member. For example, the metal layer can act as a susceptor for an electromagnetic field or can collect radiant energy supplied by an external heat source. If an internal heat source is present, the metal layer can prevent heat from escaping from the tubular element through the wrapper and can improve the efficiency of heating. It can also provide a uniform distribution of heat along the periphery of the tubular member.

[0064] In certain embodiments, the aerosol-generating article comprises a seal between the outside of the fluid guide and the inside of the wrapper. The wrapper can then be firmly attached to the fluid guide. It is not necessary to create a fluid-impermeable seal.

[0065] In certain embodiments, the aerosol-generating article comprises a mouthpiece. The mouthpiece may include a fluid guide, or a portion thereof, and may form at least a proximal portion of the wrapper of the aerosol-generating article. The mouthpiece may be connected to the wrapper, or to the distal portion of the wrapper, in any suitable manner, such as by interference fit, screw engagement, or the like. The mouthpiece may be the portion of the aerosol-generating article that includes a filter, or, in some cases, the mouthpiece may be defined by the extent of tipping paper, if present. In another embodiment, the mouthpiece may be defined as a portion of the article that extends 40 millimeters from the mouth-side end of the aerosol-generating article, or that extends 30 millimeters from the mouth-side end of the aerosol-generating article.

[0066] A tubular element containing a gel composition may be disposed within the aerosol-generating article proximally of the distal end prior to final assembly of the aerosol-generating article.

[0067] When fully assembled, the aerosol-generating article defines a fluid passage through which fluid can flow. When a negative pressure is provided at the mouth-side end (proximal end) of the aerosol-generating article, fluid enters the aerosol-generating article through the openings of the wrapper (or the fluid guide or both), and then flows through the outer longitudinal-axis passage towards the distal end of the aerosol-generating article. The aerosol may optionally be accompanied by an aerosol generated by heating a tubular element that holds the gel composition. The fluid with the entrained aerosol may then flow through the inner longitudinal-axis passage of the fluid guide and out through the open mouth-side end of the aerosol-generating article.

[0068] Preferably, the aerosol-generating article is configured to be received by an aerosol-generating device such that a heating element of the aerosol-generating device can heat a section of the aerosol-generating article that includes the tubular element. For example, if a tubular element containing a gel composition is disposed at or near the distal end of the aerosol-generating article, the tubular element may be the distal end of the aerosol-generating article.

[0069] Preferably, the aerosol-generating article can be shaped and sized for use in a suitable and correspondingly shaped and sized aerosol-generating device comprising a receptacle for receiving the aerosol-generating article and a heating element configured and arranged to heat a section of the aerosol-generating article that contains the gel composition.

[0070] The aerosol-generating device preferably includes control electronics operably coupled to the heating element. The control electronics can be configured to control the heating of the heating element. The control electronics can be internal to the housing.

[0071] According to the present disclosure, the gel composition includes an alkaloid compound, or a cannabinoid compound, or both an alkaloid compound and a cannabinoid compound, an aerosol former, a thickening agent, a hydrogen-bond crosslinking gelling agent, an ion-crosslinking gelling agent, and an acid. The gel composition can further include a divalent cation.

[0072] According to the present disclosure, the gel composition includes nicotine, an aerosol former, a thickening agent, a hydrogen-bond crosslinking gelling agent, an ion-crosslinking gelling agent, and an acid. The gel composition can further include a divalent cation.

[0073] The gel composition contains an aerosol former. Ideally, the aerosol former is substantially resistant to thermal degradation at the operating temperature of the associated aerosol generating device. Suitable aerosol formers include, but are not limited to, polyhydric alcohols (such as triethylene glycol, 1,3 - butanediol, glycerin), esters of polyhydric alcohols (such as glycerol monoacetate, diacetate, or triacetate), and aliphatic esters of monocarboxylic acids, dicarboxylic acids, or polycarboxylic acids (such as dimethyl dodecanedioate, dimethyl tetradecanedioate). The polyhydric alcohol or a mixture thereof can be one or more of triethylene glycol, 1,3 - butanediol, and glycerin (glycerol or propane - 1,2,3 - triol) or polyethylene glycol. The aerosol former is preferably glycerol.

[0074] The gel composition contains a majority of the aerosol former. The gel composition can contain a mixture of water and the aerosol former, and the aerosol former forms a majority (by weight) of the gel composition. The aerosol former can form at least about 50% by weight of the gel composition. The aerosol former can form at least about 60% by weight, or at least about 65% by weight, or at least about 70% by weight of the gel composition. The aerosol former can form from about 70% to about 80% by weight of the gel composition. The aerosol former can form from about 70% to about 75% by weight of the gel composition.

[0075] The gel composition can contain a majority of glycerol. The gel composition can contain a mixture of water and glycerol, and glycerol can form a majority (by weight) of the gel composition. Glycerol can form at least about 50% by weight of the gel composition. Glycerol can form at least about 60% by weight, or at least about 65% by weight, or at least about 70% by weight of the gel composition. Glycerol can form from about 70% to about 80% by weight of the gel composition. Glycerol can form from about 70% to about 75% by weight of the gel composition.

[0076] The gel composition preferably contains no water or only a low level of water. When the gel composition contains no water or only a low level of water, the gel composition may contain higher levels of aerosol formers, gelling agents, thickeners, and other compounds such as nicotine. Also, a gel composition that contains no water or only a low level of water is simpler and requires less energy for vaporization. An aerosol formed from a gel composition that contains no water or only a low level of water may be perceived by the user as not being very hot. Preferably, the gel composition contains less than about 40% by weight, preferably less than about 30% by weight, preferably less than about 25% by weight of water. The gel composition may contain less than about 20% by weight, or less than about 15% by weight, or less than about 10% by weight, or less than about 5% by weight of water.

[0077] The gel composition preferably contains some water. When the composition contains some water, the gel composition is more stable. Preferably, the gel composition contains at least about 1% by weight, or at least about 2% by weight, or at least about 5% by weight of water. Preferably, the gel composition contains at least about 10% by weight, or at least about 15% by weight of water.

[0078] Preferably, the gel composition contains from about 8% to about 32% by weight of water. Preferably, the gel composition contains from about 14% to about 26% by weight of water. Preferably, the gel composition contains from about 18% to about 22% by weight of water. Preferably, the gel composition contains about 20% by weight of water. Preferably, the gel composition contains from about 15% to about 25% by weight of water.

[0079] The gel composition may contain a specific ratio of water to glycerol content to maintain a local humidity equilibrated with the ambient environmental humidity. This range of water relative to the glycerol content can provide the properties necessary to maintain the gel composition. The gel composition is not substantially fluid and substantially maintains its shape over time. The gel composition does not substantially flow and substantially maintains its mass over time. When exposed to the ambient environment or storage conditions, the gel does not substantially release water (sweat) or absorbs water over time.

[0080] Preferably, the gel composition contains an aerosol former or glycerol and water in the range of about 10:1 to about 2:1, and also in the range of about 5:1 to about 3:1. Preferably, the gel composition contains an aerosol former or glycerol and water in the range of about 4.5:1 to about 3.5:1.

[0081] The gel composition may contain a gelling agent that is a hydrogen bond cross-linked gelling agent and an ionic cross-linked gelling agent. The gel composition may further contain a thickening agent. The gelling agent may form a solid medium in which the aerosol former can be dispersed. The gelling agent may form a solid medium in which the aerosol former and water can be dispersed. The thickening agent combined with the hydrogen bond cross-linked gelling agent and the ionic cross-linked gelling agent surprisingly seems to support the solid medium and maintain the gel composition even when the gel composition contains a high level of glycerol.

[0082] The gel composition may contain a gelling agent in the range of about 0.4 wt% to about 10 wt%. Preferably, the gel composition contains a gelling agent in the range of about 0.5 wt% to about 8 wt%. Preferably, the gel composition contains a gelling agent in the range of about 1 wt% to about 6 wt%. Preferably, the gel composition contains a gelling agent in the range of about 2 wt% to about 4 wt%. Preferably, the gel composition contains a gelling agent in the range of about 2 wt% to about 3 wt%.

[0083] The gel composition contains a thickening agent in the range of about 0.2 wt% to about 5 wt%. Preferably, the composition contains a thickening agent in the range of about 0.5 wt% to about 3 wt%. Preferably, the composition contains a thickening agent in the range of about 0.5 wt% to about 2 wt%. Preferably, the composition contains a thickening agent in the range of about 1 wt% to about 2 wt%.

[0084] The gel composition may contain a thickener, a hydrogen bond cross-linking gelling agent, and an ionic cross-linking gelling agent, which are present in the gel composition in a total amount of about 1% by weight to about 8% by weight. Preferably, the gel composition may contain a thickener, a hydrogen bond cross-linking gelling agent, and an ionic cross-linking gelling agent, which are present in the gel composition in a total amount of about 2% by weight to about 6% by weight. Preferably, the gel composition may contain a thickener, a hydrogen bond cross-linking gelling agent, and an ionic cross-linking gelling agent, which are present in the gel composition in a total amount of about 3% by weight to about 5% by weight.

[0085] The gel composition may contain a thickener, a hydrogen bond cross-linking gelling agent, and an ionic cross-linking gelling agent, which are each independently present in the gel composition at about 0.3% by weight to about 3% by weight. Preferably, the gel composition may contain a thickener, a hydrogen bond cross-linking gelling agent, and an ionic cross-linking gelling agent, which are each independently present in the gel composition at about 0.5% by weight to about 2% by weight. Preferably, the gel composition may contain a thickener, a hydrogen bond cross-linking gelling agent, and an ionic cross-linking gelling agent, which are each independently present in the gel composition at about 1% by weight to about 2% by weight.

[0086] The thickener may include one or more of xanthan gum, carboxymethyl cellulose, microcrystalline cellulose, methyl cellulose, gum arabic, guar gum, lambda carrageenan, or starch. It is preferable that the thickener includes xanthan gum.

[0087] The gel composition may contain xanthan gum in the range of about 0.2% by weight to about 5% by weight. Preferably, the xanthan gum may be in the range of about 0.5% by weight to about 3% by weight. Preferably, the xanthan gum may be in the range of about 0.5% by weight to about 2% by weight. Preferably, the xanthan gum may be in the range of about 1% by weight to about 2% by weight.

[0088] The gel composition may contain carboxymethyl cellulose in the range of about 0.2 wt% to about 5 wt%. Preferably, the carboxymethyl cellulose may be in the range of about 0.5 wt% to about 3 wt%. Preferably, the carboxymethyl cellulose may be in the range of about 0.5 wt% to about 2 wt%. Preferably, the carboxymethyl cellulose may be in the range of about 1 wt% to about 2 wt%.

[0089] The gel composition may contain microcrystalline cellulose in the range of about 0.2 wt% to about 5 wt%. Preferably, the microcrystalline cellulose may be in the range of about 0.5 wt% to about 3 wt%. Preferably, the microcrystalline cellulose may be in the range of about 0.5 wt% to about 2 wt%. Preferably, the microcrystalline cellulose may be in the range of about 1 wt% to about 2 wt%.

[0090] The gel composition may contain methylcellulose in the range of about 0.2 wt% to about 5 wt%. Preferably, the methylcellulose may be in the range of about 0.5 wt% to about 3 wt%. Preferably, the methylcellulose may be in the range of about 0.5 wt% to about 2 wt%. Preferably, the methylcellulose may be in the range of about 1 wt% to about 2 wt%.

[0091] The gel composition may contain gum arabic in the range of about 0.2 wt% to about 5 wt%. Preferably, the gum arabic may be in the range of about 0.5 wt% to about 3 wt%. Preferably, the gum arabic may be in the range of about 0.5 wt% to about 2 wt%. Preferably, the gum arabic may be in the range of about 1 wt% to about 2 wt%.

[0092] The gel composition may contain guar gum in the range of about 0.2 wt% to about 5 wt%. Preferably, the guar gum may be in the range of about 0.5 wt% to about 3 wt%. Preferably, the guar gum may be in the range of about 0.5 wt% to about 2 wt%. Preferably, the guar gum may be in the range of about 1 wt% to about 2 wt%.

[0093] The gel composition may contain lambda carrageenan in the range of about 0.2 wt% to about 5 wt%. Preferably, the lambda carrageenan may be in the range of about 0.5 wt% to about 3 wt%. Preferably, the lambda carrageenan may be in the range of about 0.5 wt% to about 2 wt%. Preferably, the lambda carrageenan may be in the range of about 1 wt% to about 2 wt%.

[0094] The gel composition may contain starch in the range of about 0.2 wt% to about 5 wt%. Preferably, the starch may be in the range of about 0.5 wt% to about 3 wt%. Preferably, the starch may be in the range of about 0.5 wt% to about 2 wt%. Preferably, the starch may be in the range of about 1 wt% to about 2 wt%.

[0095] The hydrogen bond crosslinking gelling agent may contain one or more of galactomannan, gelatin, agarose, or konjac gum, or agar. The hydrogen bond crosslinking gelling agent may preferably contain agar in some cases.

[0096] The gel composition contains a hydrogen bond crosslinking gelling agent in the range of about 0.3 wt% to about 5 wt%. Preferably, the gel composition contains a hydrogen bond crosslinking gelling agent in the range of about 0.5 wt% to about 3 wt%. Preferably, the gel composition contains a hydrogen bond crosslinking gelling agent in the range of about 1 wt% to about 2 wt%.

[0097] The gel composition may contain galactomannan in the range of about 0.2 wt% to about 5 wt%. Preferably, the galactomannan may be in the range of about 0.5 wt% to about 3 wt%. Preferably, the galactomannan may be in the range of about 0.5 wt% to about 2 wt%. Preferably, the galactomannan may be in the range of about 1 wt% to about 2 wt%.

[0098] The gel composition may contain gelatin in the range of about 0.2 wt% to about 5 wt%. Preferably, the gelatin may be in the range of about 0.5 wt% to about 3 wt%. Preferably, the gelatin may be in the range of about 0.5 wt% to about 2 wt%. Preferably, the gelatin may be in the range of about 1 wt% to about 2 wt%.

[0099] The gel composition may contain agarose in the range of about 0.2 wt% to about 5 wt%. Preferably, the agarose may be in the range of about 0.5 wt% to about 3 wt%. Preferably, the agarose may be in the range of about 0.5 wt% to about 2 wt%. Preferably, the agarose may be in the range of about 1 wt% to about 2 wt%.

[0100] The gel composition may contain konjac gum in the range of about 0.2 wt% to about 5 wt%. Preferably, the konjac gum may be in the range of about 0.5 wt% to about 3 wt%. Preferably, the konjac gum may be in the range of about 0.5 wt% to about 2 wt%. Preferably, the konjac gum may be in the range of about 1 wt% to about 2 wt%.

[0101] The gel composition may contain agar in the range of about 0.2 wt% to about 5 wt%. Preferably, the agar may be in the range of about 0.5 wt% to about 3 wt%. Preferably, the agar may be in the range of about 0.5 wt% to about 2 wt%. Preferably, the agar may be in the range of about 1 wt% to about 2 wt%.

[0102] The ionic crosslinking gelling agent may include low acyl gellan, pectin, kappa carrageenan, iota carrageenan or alginate. The ionic crosslinking gelling agent preferably includes low acyl gellan.

[0103] The gel composition may contain an ionic crosslinking gelling agent in the range of about 0.3 wt% to about 5 wt%. Preferably, the gel composition contains an ionic crosslinking gelling agent in the range of about 0.5 wt% to about 3 wt%. Preferably, the composition contains an ionic crosslinking gelling agent in the range of about 1 wt% to about 2 wt%.

[0104] The gel composition may contain low acyl gellan in the range of about 0.2 wt% to about 5 wt%. Preferably, the low acyl gellan may be in the range of about 0.5 wt% to about 3 wt%. Preferably, the low acyl gellan may be in the range of about 0.5 wt% to about 2 wt%. Preferably, the low acyl gellan may be in the range of about 1 wt% to about 2 wt%.

[0105] The gel composition may contain pectin in the range of about 0.2 wt% to about 5 wt%. Preferably, the pectin may be in the range of about 0.5 wt% to about 3 wt%. Preferably, the pectin may be in the range of about 0.5 wt% to about 2 wt%. Preferably, the pectin may be in the range of about 1 wt% to about 2 wt%.

[0106] The gel composition may contain kappa-carrageenan in the range of about 0.2 wt% to about 5 wt%. Preferably, the kappa-carrageenan may be in the range of about 0.5 wt% to about 3 wt%. Preferably, the kappa-carrageenan may be in the range of about 0.5 wt% to about 2 wt%. Preferably, the kappa-carrageenan may be in the range of about 1 wt% to about 2 wt%.

[0107] The gel composition may contain iota-carrageenan in the range of about 0.2 wt% to about 5 wt%. Preferably, the iota-carrageenan may be in the range of about 0.5 wt% to about 3 wt%. Preferably, the iota-carrageenan may be in the range of about 0.5 wt% to about 2 wt%. Preferably, the iota-carrageenan may be in the range of about 1 wt% to about 2 wt%.

[0108] The gel composition may contain alginate in the range of about 0.2 wt% to about 5 wt%. Preferably, the alginate may be in the range of about 0.5 wt% to about 3 wt%. Preferably, the alginate may be in the range of about 0.5 wt% to about 2 wt%. Preferably, the alginate may be in the range of about 1 wt% to about 2 wt%.

[0109] The gel composition may contain a hydrogen-bond crosslinking gelling agent and an ionic crosslinking gelling agent in a ratio of about 3:1 to about 1:3. Preferably, the gel composition may contain a hydrogen-bond crosslinking gelling agent and an ionic crosslinking gelling agent in a ratio of about 2:1 to about 1:2. Preferably, the gel composition may contain a hydrogen-bond crosslinking gelling agent and an ionic crosslinking gelling agent in a ratio of about 1:1.

[0110] The gel composition may contain a hydrogen-bond crosslinking gelling agent and a thickener in a ratio of about 3:1 to about 1:3. Preferably, the gel composition may contain a hydrogen-bond crosslinking gelling agent and a thickener in a ratio of about 2:1 to about 1:2. Preferably, the gel composition may contain a hydrogen-bond crosslinking gelling agent and a thickener in a ratio of about 1:1.

[0111] The gel composition may contain an ion crosslinking gelling agent and a thickener in a ratio of about 3:1 to about 1:3. Preferably, the gel composition may contain an ion crosslinking gelling agent and a thickener in a ratio of about 2:1 to about 1:2. Preferably, the gel composition may contain an ion crosslinking gelling agent and a thickener in a ratio of about 1:1.

[0112] The gel composition may contain a gelling agent and an alkaloid compound in a ratio of about 3:1 to about 1:3. Preferably, the gel composition may contain a gelling agent and an alkaloid compound in a ratio of about 2:1 to about 1:2. Preferably, the gel composition may contain a gelling agent and an alkaloid compound in a ratio of about 1:1.

[0113] The gel composition may contain a thickener and an alkaloid compound in a ratio of about 1:1 to about 1:5. Preferably, the gel composition may contain a thickener and an alkaloid compound in a ratio of about 1:1 to about 1:3. Preferably, the gel composition may contain a thickener and an alkaloid compound in a ratio of about 1:2.

[0114] The gel composition may contain an alkaloid compound and water in a ratio of about 1:5 to about 1:20. Preferably, the gel composition may contain an alkaloid compound and water in a ratio of about 1:8 to about 1:12. Preferably, the gel composition may contain an alkaloid compound and water in a ratio of about 1:10.

[0115] The gel composition may contain an alkaloid compound and glycerol in a ratio of about 1:50 to about 1:25. Preferably, the gel composition may contain an alkaloid compound and glycerol in a ratio of about 1:40 to about 1:30. Preferably, the gel composition may contain an alkaloid compound and glycerol in a ratio of about 1:36.

[0116] The gel composition may contain a gelling agent and nicotine in a ratio of about 3:1 to about 1:3. Preferably, the gel composition may contain a gelling agent and nicotine in a ratio of about 2:1 to about 1:2. Preferably, the gel composition may contain a gelling agent and nicotine in a ratio of about 1:1.

[0117] The gel composition may contain a thickening agent and nicotine in a ratio of about 1:1 to about 1:5. Preferably, the gel composition may contain a thickening agent and nicotine in a ratio of about 1:1 to about 1:3. Preferably, the gel composition may contain a thickening agent and nicotine in a ratio of about 1:2.

[0118] The gel composition may contain nicotine and water in a ratio of about 1:5 to about 1:20. Preferably, the gel composition may contain nicotine and water in a ratio of about 1:8 to about 1:12. Preferably, the gel composition may contain nicotine and water in a ratio of about 1:10.

[0119] The gel composition may contain nicotine and glycerol in a ratio of about 1:50 to about 1:25. Preferably, the gel composition may contain nicotine and glycerol in a ratio of about 1:40 to about 1:30. Preferably, the gel composition may contain nicotine and glycerol in a ratio of about 1:36.

[0120] The gel composition may contain a gelling agent and glycerol in a ratio of about 1:50 to about 1:25. Preferably, the gel composition may contain a gelling agent and glycerol in a ratio of about 1:40 to about 1:30. Preferably, the gel composition may contain a gelling agent and glycerol in a ratio of about 1:36.

[0121] The gel composition may contain a thickening agent and glycerol in a ratio of about 1:90 to about 1:40. Preferably, the gel composition may contain a thickening agent and glycerol in a ratio of about 1:80 to about 1:65. Preferably, the gel composition may contain a thickening agent and glycerol in a ratio of about 1:73.

[0122] The gel composition may contain a gelling agent and a cannabinoid compound in a ratio of about 3:1 to about 1:3. Preferably, the gel composition may contain a gelling agent and a cannabinoid compound in a ratio of about 2:1 to about 1:2. Preferably, the gel composition may contain a gelling agent and a cannabinoid compound in a ratio of about 1:1.

[0123] The gel composition may contain a thickening agent and a cannabinoid compound in a ratio of about 1:1 to about 1:5. Preferably, the gel composition may contain a thickening agent and a cannabinoid compound in a ratio of about 1:1 to about 1:3. Preferably, the gel composition may contain a thickening agent and a cannabinoid compound in a ratio of about 1:2.

[0124] The gel composition may contain a cannabinoid compound and water in a ratio of about 1:5 to about 1:20. Preferably, the gel composition may contain a cannabinoid compound and water in a ratio of about 1:8 to about 1:12. Preferably, the gel composition may contain a cannabinoid compound and water in a ratio of about 1:10.

[0125] The gel composition may contain a cannabinoid compound and glycerol in a ratio of about 1:50 to about 1:25. Preferably, the gel composition may contain a cannabinoid compound and glycerol in a ratio of about 1:40 to about 1:30. Preferably, the gel composition may contain a cannabinoid compound and glycerol in a ratio of about 1:36.

[0126] The gel composition may contain both a gelling agent and an alkaloid compound and a cannabinoid compound in a ratio of about 3:1 to about 1:3. Preferably, the gel composition may contain both a gelling agent and an alkaloid compound and a cannabinoid compound in a ratio of about 2:1 to about 1:2. Preferably, the gel composition may contain both a gelling agent and an alkaloid compound and a cannabinoid compound in a ratio of about 1:1.

[0127] The gel composition may contain both a thickening agent and both an alkaloid compound and a cannabinoid compound in a ratio of about 1:1 to about 1:5. Preferably, the gel composition may contain both a thickening agent and both an alkaloid compound and a cannabinoid compound in a ratio of about 1:1 to about 1:3. Preferably, the gel composition may contain both a thickening agent and both an alkaloid compound and a cannabinoid compound in a ratio of about 1:2.

[0128] The gel composition may contain both an alkaloid compound and a cannabinoid compound and water in a ratio of about 1:5 to about 1:20. Preferably, the gel composition may contain both an alkaloid compound and a cannabinoid compound and water in a ratio of about 1:8 to about 1:12. Preferably, the gel composition may contain both an alkaloid compound and a cannabinoid compound and water in a ratio of about 1:10.

[0129] The gel composition may contain both an alkaloid compound and a cannabinoid compound and glycerol in a ratio of about 1:50 to about 1:25. Preferably, the gel composition may contain both an alkaloid compound and a cannabinoid compound and glycerol in a ratio of about 1:40 to about 1:30. Preferably, the gel composition may contain both an alkaloid compound and a cannabinoid compound and glycerol in a ratio of about 1:36.

[0130] The gel composition may further contain a divalent cation. Preferably, the divalent cation includes calcium ions such as calcium lactate in the solution. Divalent cations (such as calcium ions) may assist in the gel formation of a composition containing a gelling agent such as an ionic crosslinking gelling agent. The ionic effect may assist in gel formation. The divalent cation may be present in the gel composition in the range of about 0.1 to about 1% by weight, or about 0.5% by weight.

[0131] The gel composition may further contain an acid. The acid may include a carboxylic acid. The carboxylic acid may contain a ketone group. Preferably, the carboxylic acid may contain a ketone group having less than about 10 carbon atoms, or less than about 6 carbon atoms, or less than about 4 carbon atoms, such as levulinic acid or lactic acid. Preferably, this carboxylic acid has three carbon atoms (such as lactic acid). Surprisingly, lactic acid improves the stability of the gel composition even more than similar carboxylic acids. The carboxylic acid may assist in gel formation. The carboxylic acid may reduce the change in the concentration of the alkaloid compound, or the cannabinoid compound, or both the alkaloid compound concentration and the cannabinoid compound concentration in the gel composition during storage. The carboxylic acid may reduce the change in the nicotine concentration in the gel composition during storage.

[0132] The gel composition may contain the carboxylic acid in the range of about 0.1% by weight to about 5% by weight. Preferably, the carboxylic acid may be in the range of about 0.5% by weight to about 3% by weight. Preferably, the carboxylic acid may be in the range of about 0.5% by weight to about 2% by weight. Preferably, the carboxylic acid may be in the range of about 1% by weight to about 2% by weight.

[0133] The gel composition may contain lactic acid in the range of about 0.1% by weight to about 5% by weight. Preferably, lactic acid may be in the range of about 0.5% by weight to about 3% by weight. Preferably, lactic acid may be in the range of about 0.5% by weight to about 2% by weight. Preferably, lactic acid may be in the range of about 1% by weight to about 2% by weight.

[0134] The gel composition may contain levulinic acid in the range of about 0.1% by weight to about 5% by weight. Preferably, levulinic acid may be in the range of about 0.5% by weight to about 3% by weight. Preferably, levulinic acid may be in the range of about 0.5% by weight to about 2% by weight. Preferably, levulinic acid may be in the range of about 1% by weight to about 2% by weight.

[0135] The gel composition may contain a carboxylic acid and an alkaloid compound in a ratio of about 2:1 to about 1:2. Preferably, the gel composition may contain a carboxylic acid and an alkaloid compound in a ratio of about 1:1.5 to about 1.5:1. Preferably, the gel composition may contain a carboxylic acid and an alkaloid compound in a ratio of about 1:1.

[0136] The gel composition may contain a carboxylic acid and nicotine in a ratio of about 2:1 to about 1:2. Preferably, the gel composition may contain a carboxylic acid and nicotine in a ratio of about 1:1.5 to about 1.5:1. Preferably, the gel composition may contain a carboxylic acid and nicotine in a ratio of about 1:1.

[0137] The gel composition may contain a carboxylic acid and a cannabinoid compound in a ratio of about 2:1 to about 1:2. Preferably, the gel composition may contain a carboxylic acid and a cannabinoid compound in a ratio of about 1:1.5 to about 1.5:1. Preferably, the gel composition may contain a carboxylic acid and a cannabinoid compound in a ratio of about 1:1.

[0138] The gel composition may contain both a carboxylic acid and both an alkaloid compound and a cannabinoid compound in a ratio of about 2:1 to about 1:2. Preferably, the gel composition may contain both a carboxylic acid and both an alkaloid compound and a cannabinoid compound in a ratio of about 1:1.5 to about 1.5:1. Preferably, the gel composition may contain both a carboxylic acid and both an alkaloid compound and a cannabinoid compound in a ratio of about 1:1.

[0139] The gel composition may contain a carboxylic acid and a thickener in a ratio of about 2:1 to about 1:2. Preferably, the gel composition may contain a carboxylic acid and a thickener in a ratio of about 1:1.5 to about 1.5:1. Preferably, the gel composition may contain a carboxylic acid and a thickener in a ratio of about 1:1.

[0140] The gel composition may contain a carboxylic acid and a gelling agent in a ratio of about 2:1 to about 1:4. Preferably, the gel composition may contain a carboxylic acid and a gelling agent in a ratio of about 1:1 to about 1:3. Preferably, the gel composition may contain a carboxylic acid and a gelling agent in a ratio of about 1:2.

[0141] The gel composition may contain carboxylic acid and glycerol in a ratio of about 1:70 to about 1:30. Preferably, the gel composition may contain carboxylic acid and glycerol in a ratio of about 1:60 to about 1:50. Preferably, the gel composition may contain carboxylic acid and glycerol in a ratio of about 1:55.

[0142] The gel composition may contain carboxylic acid and water in a ratio of about 1:30 to about 1:5. Preferably, the gel composition may contain carboxylic acid and water in a ratio of about 1:20 to about 1:10. Preferably, the gel composition may contain carboxylic acid and water in a ratio of about 1:15.

[0143] An alkaloid compound, or a cannabinoid compound, or both an alkaloid compound and a cannabinoid compound are included in the gel composition. The gel composition includes about 0.5 wt% to about 10 wt% of an alkaloid compound, or about 0.5 wt% to about 10 wt% of a cannabinoid compound, or both an alkaloid compound and a cannabinoid compound with a total amount of about 0.5 wt% to about 10 wt%. The gel composition may include about 0.5 wt% to about 5 wt% of an alkaloid compound, or about 0.5 wt% to about 5 wt% of a cannabinoid compound, or both an alkaloid compound and a cannabinoid compound with a total amount of about 0.5 wt% to about 5 wt%. Preferably, the gel composition includes about 1 wt% to about 3 wt% of an alkaloid compound, or about 1 wt% to about 3 wt% of a cannabinoid compound, or both an alkaloid compound and a cannabinoid compound with a total amount of about 1 wt% to about 3 wt%. The gel composition may preferably include about 1.5 wt% to about 2.5 wt% of an alkaloid compound, or about 1.5 wt% to about 2.5 wt% of a cannabinoid compound, or both an alkaloid compound and a cannabinoid compound with a total amount of about 1.5 wt% to about 2.5 wt%. The gel composition may preferably include about 2 wt% of an alkaloid compound, or about 2 wt% of a cannabinoid compound, or both an alkaloid compound and a cannabinoid compound with a total amount of about 2 wt%. The alkaloid compound component of the gel formulation may be the most volatile component of the gel formulation. In some embodiments, water may be the most volatile component of the gel formulation, and the alkaloid compound component of the gel formulation may be the second most volatile component of the gel formulation. The cannabinoid compound component of the gel formulation may be the most volatile component of the gel formulation. In some embodiments, water may be the most volatile component of the gel formulation, and the alkaloid compound component of the gel formulation may be the second most volatile component of the gel formulation.

[0144] Preferably, nicotine is included in the gel composition. Nicotine can be added to the composition in free base form or in salt form. The gel composition contains from about 0.5% to about 10% by weight of nicotine, or from about 0.5% to about 5% by weight of nicotine. Preferably, the gel composition contains from about 1% to about 3% by weight of nicotine, or from about 1.5% to about 2.5% by weight of nicotine, or about 2% by weight of nicotine. The nicotine component of the gel formulation may be the most volatile component of the gel formulation. In some embodiments, water can be the most volatile component of the gel formulation, and the nicotine component of the gel formulation can be the second most volatile component of the gel formulation.

[0145] In embodiments where agar is used as the hydrogen bond cross-linking gelling agent, the gel composition contains 0.2 - 5% by weight, preferably 0.5 - 2% by weight of agar. Preferably, this gel composition may contain 0.2 - 5% by weight, preferably 0.5 - 2% by weight of an ionic cross-linking gelling agent such as low acyl gellan or alginate. Preferably, this gel composition may contain 0.2 - 5% by weight, preferably 0.5 - 2% by weight of a thickening agent such as xanthan gum. Preferably, the gel further contains 0.1 - 2% by weight of an alkaloid compound, or 0.1 - 2% by weight of a cannabinoid compound. Preferably, the gel further contains 0.1 - 2% by weight of an alkaloid compound, or 0.1 - 2% by weight of a cannabinoid compound, or both an alkaloid compound and a cannabinoid compound in a total amount of 0.1 - 2% by weight. Preferably, the gel further contains 0.1 - 2% by weight of nicotine. Preferably, the gel further contains 70% - 80% (or 70% - 75%) by weight of glycerol. Preferably, the gel composition further contains a divalent cation such as calcium. In certain embodiments, the remainder of the gel contains water and any flavoring agent. Preferably, the gel composition further contains an acid in an amount of about 0.5% to about 2.5% by weight, or a carboxylic acid such as lactic acid.

[0146] In an embodiment where low acyl gellan is used as an ionic crosslinking gelling agent, the gel composition contains 0.2 to 5% by weight, preferably 0.5 to 2% by weight, of low acyl gellan. Preferably, this gel composition may contain 0.2 to 5% by weight, preferably 0.5 to 2% by weight, of a hydrogen bond crosslinking gelling agent such as agar. Preferably, this gel composition may contain 0.2 to 5% by weight, preferably 0.5 to 2% by weight, of a thickening agent such as xanthan gum. Preferably, the gel further contains 0.1 to 2% by weight of an alkaloid compound, or 0.1 to 2% by weight of a cannabinoid compound, or both an alkaloid compound and a cannabinoid compound in a total amount of 0.1 to 2% by weight. Preferably, the gel further contains 0.1 to 2% by weight of nicotine. Preferably, the gel further contains 70% to 80% by weight (or 70% to 75% by weight) of glycerol. Preferably, the gel composition further contains a divalent cation such as calcium. In a particular embodiment, the remainder of the gel contains water and any flavoring agent. Preferably, the gel composition further contains an acid in an amount of about 0.5% to about 2.5% by weight, or a carboxylic acid such as lactic acid.

[0147] The gel composition may contain about 1.5% to about 2.5% by weight of an alkaloid compound, or about 1.5% to 2.5% by weight of a cannabinoid compound, or both an alkaloid compound and a cannabinoid compound in a total amount of about 1.5% to 2.5% by weight, about 70% to about 75% by weight of glycerol, about 18% to about 22% by weight of water, about 0.5% to about 2% by weight each of agar, xanthan gum, and low acyl gellan, and calcium ions. Each of xanthan gum, agar, and low acyl gellan may be present in substantially equal amounts in the gel composition.

[0148] The gel composition may contain about 1.5% to about 2.5% by weight of nicotine, about 70% to about 75% by weight of glycerol, about 18% to about 22% by weight of water, about 0.5% to about 2% by weight each of agar, xanthan gum, and low acyl gellan, and calcium ions. Each of xanthan gum, agar, and low acyl gellan may be present in substantially equal amounts in the gel composition.

[0149] The gel composition can be heated (via an aerosol generating device) to vaporize an alkaloid compound, or a cannabinoid compound, or both an alkaloid compound and a cannabinoid compound. The gel composition may be heated (via an aerosol generating device) to vaporize nicotine. Heating of the gel composition may not release a liquid phase.

[0150] All scientific and technical terms used herein have the meanings commonly used in the art, unless otherwise specified. The definitions provided herein are provided to facilitate understanding of specific terms frequently used herein.

[0151] As used herein, the singular forms “a,” “an,” and “the” include embodiments having a plural referent, unless the context clearly dictates otherwise.

[0152] As used herein, “or” is generally used in the sense of “and / or,” unless the context clearly dictates otherwise. The term “and / or” means one or all of the listed elements, or any combination of two or more of the listed elements.

[0153] As used herein, “have,” “having,” “include,” “including,” “comprise,” “comprising,” or the like are used in an unrestricted sense and generally mean “including but not limited to.” Of course, “consisting essentially of,” “consisting of,” and the like are subsumed by “comprising” and the like.

[0154] The terms "preferred" and "preferably" refer to embodiments of the present invention that may provide certain advantages under certain circumstances. However, under the same or other circumstances, other embodiments may also be preferred. Moreover, the recitation of one or more preferred embodiments does not imply that other embodiments are not useful, nor is it intended to exclude other embodiments from the scope of the disclosure, including the claims.

[0155] Reference will now be made to the drawings that depict one or more aspects described in this disclosure. However, it should be understood that other aspects not illustrated in the drawings are also within the scope of the disclosure. Similar numbers used within the figures refer to similar components, steps, and the like. However, it is not intended that the use of one number to refer to a component in a given figure limits the component with the same number in other figures. Additionally, the use of different numbers to refer to components in different figures is not intended to indicate that components with different numbers cannot be the same or similar to components with other numbers. The drawings are presented for illustrative purposes and not for limiting purposes. The schematic diagrams presented in the drawings are not necessarily to scale.

Brief Description of the Drawings

[0156]

Figure 1

Figure 2

Figure 3

Modes for Carrying Out the Invention

[0157] Figures 1 to 2 show examples of an aerosol-generating article 100 and an aerosol-generating device 200. The aerosol-generating article 100 has a proximal or mouth-side end 101 and a distal end 103. In Figure 2, the distal end 103 of the aerosol-generating article 100 is received in a receptacle 220 of the aerosol-generating device 200. The aerosol-generating device 200 includes a housing 210 that defines a receptacle 220 configured to receive the aerosol-generating article 100. The aerosol-generating device 200 also includes a heating element 230 that forms a cavity 235 configured to receive the aerosol-generating article 100, preferably by interference fit. The heating element 230 may include an electrical resistance heating component. Further, the device 200 includes a power source 240 and control electronics 250 that cooperate to control the heating of the heating element 230.

[0158] The heating element 230 may heat the distal end 103 of the aerosol-generating article 100 that contains a tubular element 600 (not shown). In this example, the tubular element 600 contains a gel composition 500 that includes nicotine. By heating the aerosol-generating article 100, a nicotine-containing aerosol is generated in the tubular element 600 that contains the gel composition 500, and it can exit the aerosol-generating article 100 at the proximal end 101.

[0159] Figures 1 to 2 do not show the exact heating mechanism.

[0160] In some examples, the heating mechanism may be by conduction heating in which heat is transferred from the heating element 230 of the aerosol-generating device 200 to the aerosol-generating article 100. This can be easily done when the aerosol-generating article 100 is positioned in the receptacle 220 of the aerosol-generating device 200, and the distal end 103 (preferably the end where the tubular element 600 that contains the gel composition 500 is located) and, thus, the aerosol-generating article 100 are in contact with the heating element 230 of the aerosol-generating device 200. In a particular embodiment, the heating element includes a heating blade that protrudes from the aerosol-generating device 200 and is suitable for penetrating into the aerosol-generating article 100 to directly contact the gel composition 500 of the tubular element 600.

[0161] In this embodiment, the heating mechanism is by induction in which the heating element emits radiative magnetic radiation that is absorbed by the tubular element when the aerosol generating article 100 is positioned within the receptacle 220 of the aerosol generating device 200.

[0162] FIG. 3 illustrates one embodiment of an aerosol generating article 100 including a wrapper 110 and a fluid guide 400.

[0163] The fluid guide 400 has a proximal end 401, a distal end 403, and an inner longitudinal axis direction passage 430 extending from the distal end 403 to the proximal end 401. The inner longitudinal axis direction passage 430 has a first portion 410 and a second portion 420. The first portion 410 defines a first portion of the passage 430 that extends from the distal end 413 of the first portion 410 to the proximal end 411 of the first portion 410. The second portion 420 defines a second portion of the passage 430 that extends from the distal end 423 of the second portion 420 to the proximal end 421 of the second portion 420. The first portion 410 of the passage 430 has a compressed cross-sectional area such that when a negative pressure is applied to the proximal end 101 of the aerosol generating article 100, a fluid such as air accelerates through this first portion 410 of the inner longitudinal axis direction passage 430 and moves from the distal end 413 to the proximal end 411 of the first portion 410. The cross-sectional area of the first portion 410 of the inner longitudinal axis direction passage 430 narrows from the distal end 413 to the proximal end 411 of the first portion 410. The second portion 420 of the inner longitudinal axis direction passage 430 has a cross-sectional area that expands from the distal end 423 to the proximal end 421 of the second portion 420 of the fluid guide 400. In the second portion 420 of the inner longitudinal axis direction passage 430, the fluid can decelerate.

[0164] The wrapper 110 defines the open proximal end 101 and the distal end 103 of the aerosol-generating article 100. A tubular element 600 containing the gel composition 500 is disposed at the distal end 103 of the aerosol-generating article 100. The aerosol-generating article 100 comprises an end plug at its extreme distal end 103. The end plug is positioned on the distal side of the tubular element 600. The end plug contains a material with high resistance to suction, and thus when a negative pressure is applied to the proximal end 101 of the aerosol-generating article 100, it biases the fluid to enter the aerosol-generating article 100 through the opening 150. The aerosol generated or released from the tubular element 600 contains nicotine and, when heated, enters the cavity 140 of the aerosol-generating article downstream from the tubular element 600 and is conveyed through the inner longitudinal axis passage 430.

[0165] The opening 150 penetrates the wrapper 110. At least one opening 150 communicates with an outer longitudinal axis passage 440 formed between the outer surface of the fluid guide 400 and the inner surface of the wrapper 110. A seal is formed between the fluid guide 400 and the wrapper 110 at a position between the opening 150 and the mouth-side end 101.

[0166] When a negative pressure is applied to the proximal end 101 of the aerosol-generating article 100, the fluid enters the opening 150, passes through the outer longitudinal axis passage 440 into the cavity 140, and then flows to the tubular element 600 containing the gel composition, where the fluid takes in the aerosol when the tubular element 600 containing the gel composition is heated. The fluid then flows through the inner longitudinal axis passage 430 and through the proximal end 101 of the aerosol-generating article 100. When the fluid flows through the first portion 410 of the inner longitudinal axis passage 430, the fluid accelerates. When the fluid flows through the second portion of the inner longitudinal axis passage 430, the fluid decelerates. In the illustrated embodiment, the wrapper 110 defines a proximal cavity 130 between the proximal end 401 of the fluid guide 400 and the proximal end 101 of the article 100, which can help to decelerate the fluid before it exits the mouth-side end 101.

Example

[0167] Table 1 describes the formulated gel composition formulations. Table 1:

Table 1

[0168] Indentation test Measurements were made using an Anton Parr PNR12 penetrometer and a quarter - cone plate. The sample (gel composition) was loaded below the needle and manually aligned with the top of the sample surface. The tip of the shadow of the needle on the sample was brought into contact with the needle. At least three measurements were made per sample. The average distance penetrated was measured for each gel.

[0169] Example 1 had a penetration distance of approximately 7.5 mm.

[0170] Example 2 had a penetration distance of approximately 7.7 mm.

[0171] Example 3 had a penetration distance of approximately 7.0 mm.

[0172] Example 4 had a penetration distance of approximately 3.8 mm.

[0173] Example 9 had a penetration distance of approximately 5.0 mm.

[0174] The longer the penetration distance, the softer the gel composition.

[0175] Weight change of the gel composition over time The weights of the formulations of several examples were evaluated over 45 days at various relative humidities. A stable gel composition maintains its initial weight substantially over 45 days.

[0176] Example 4 was weighed over 45 days at three relative humidity levels (10%, 60%, and 70%). At 60% relative humidity, this gel composition added approximately 10% to its weight over 45 days, and almost all of this weight gain occurred in the first 5 days. At 10% relative humidity, this gel composition lost approximately 15% of its weight over 45 days, and almost all of this weight loss occurred in the first 5 days. At 70% relative humidity, this gel composition added approximately 25% to its weight over 45 days, and almost all of this weight gain occurred in the first 5 days. At all three relative humidity levels (10%, 60%, and 70%), no liquid phase was observed.

[0177] Example 2 was weighed over 45 days at three relative humidity levels (10%, 60%, and 70%). At 60% relative humidity, this gel composition added approximately 15% to its weight over 45 days, and almost all of this weight gain occurred in the first 5 days. At 10% relative humidity, this gel composition lost approximately 5% of its weight over 45 days, and almost all of this weight loss occurred in the first 5 days. At 70% relative humidity, this gel composition added approximately 45% to its weight over 45 days, and almost all of this weight gain occurred in the first 5 days.

[0178] Further Examples Table 2 describes the formulated gel composition formulations. Table 2:

Table 2

[0179] 1. A gel composition, an alkaloid compound, or a cannabinoid compound, or both an alkaloid compound and a cannabinoid compound, at least about 50% by weight of glycerol, at least about 0.2% by weight of an ionic crosslinking gelling agent, at least about 0.2% by weight of a thickening agent or at least 0.2% by weight of a hydrogen bonding crosslinking gelling agent, and, A gel composition containing an acid. 2. Nicotine, At least about 50% by weight of glycerol, At least about 0.2% by weight of an ionic crosslinking gelling agent, At least about 0.2% by weight of a thickening agent or at least 0.2% by weight of a hydrogen-bond crosslinking gelling agent, and An acid-containing gel composition according to 1. 3. About 0.5% to about 2.5% by weight of nicotine, At least about 70% by weight of glycerol, At least about 0.5% by weight of a hydrogen-bond crosslinking gelling agent, At least about 0.5% by weight of a thickening agent, At least about 0.5% by weight of an ionic crosslinking gelling agent, Divalent ions, and An acid-containing gel composition according to 2. 4. The gel composition according to any one of 1 to 3, wherein the composition contains about 0.5% to about 5% by weight of an acid. 5. The gel composition according to any one of 1 to 4, wherein the acid contains lactic acid. 6. The gel composition according to any one of 1 to 5, wherein the acid contains levulinic acid. 7. The gel composition according to any one of 1 to 6, further containing calcium ions. 8. The gel composition according to any one of 1 to 7, wherein the thickening agent, hydrogen-bond crosslinking gelling agent, and ionic crosslinking gelling agent are each present in the gel composition at about 0.5% to about 2.5% by weight. 9. About 0.5% to about 2.5% by weight of nicotine, About 70% to about 80% by weight of glycerol, About 0.5% to about 2% by weight of a thickening agent, About 0.5% to about 2% by weight of a hydrogen-bond crosslinking gelling agent, About 0.5% to about 2% by weight of an ionic crosslinking gelling agent, About 0.5% to about 2.5% by weight of a carboxylic acid, Divalent ions, and The gel composition according to 2, containing about 15% to about 25% by weight of water. 10. The gel composition according to any one of 1 to 9, wherein the thickener contains xanthan gum. 11. The gel composition according to any one of 1 to 10, wherein the hydrogen bond crosslinking gelling agent contains agar. 12. The gel composition according to any one of 1 to 11, wherein the ionic crosslinking gelling agent contains low acyl gellan. 13. About 1.5 to about 2.5% by weight of nicotine, about 70 to about 75% by weight of glycerol, about 18 to about 22% by weight of water, about 0.5 to 2% of agar about 0.5 to 2% of xanthan gum, about 0.5 to 2% of low acyl gellan, about 0.5% by weight to about 2.5% by weight of carboxylic acid, divalent ions, and about 15% by weight to about 25% by weight of water, and the gel composition according to 2. 14. The gel composition according to 13, wherein the acid contains lactic acid. 15. The gel composition according to 13 or 14, containing calcium ions. 16. Use of the gel composition according to any one of 1 to 15 by heating the gel composition to vaporize the alkaloid compound, or the cannabinoid compound, or both the alkaloid compound and the cannabinoid compound.

Claims

1. 0.5 wt% to 5 wt% nicotine, 50 wt% to 80 wt% glycerol, 0.3 wt% to 5 wt% ionic crosslinking gelling agent, 0.1 wt% to 1 wt% divalent cation, 0.1 wt% to 5 wt% carboxylic acid, and 0.2 wt% to 5 wt% thickening agent, comprising, wherein the thickening agent comprises xanthan gum, carboxymethyl cellulose, microcrystalline cellulose, methyl cellulose, gum arabic, guar gum, lambda carrageenan, or starch gel composition.

2. The gel composition according to claim 1, wherein the divalent cation is calcium ion.

3. The gel composition according to claim 1 or 2, comprising 0.5 wt% to 2 wt% carboxylic acid.

4. The gel composition according to any one of claims 1 to 3, comprising 1 wt% to 3 wt% nicotine.

5. The gel composition according to any one of claims 1 to 4, comprising 0.5 wt% to 3 wt% thickening agent.

6. The gel composition according to any one of claims 1 to 5, further comprising 0.2 wt% to 5 wt% hydrogen bond crosslinking gelling agent.

7. The gel composition according to claim 6, comprising 0.5 wt% to 3 wt% hydrogen bond crosslinking gelling agent.

8. The gel composition according to any one of claims 1 to 7, comprising 0.3 wt% to 3 wt% ionic crosslinking gelling agent.

9. The gel composition according to any one of claims 1 to 8, further comprising water.

10. The gel composition according to claim 9, comprising 8 wt% to 32 wt% water.

11. The gel composition according to claim 10, comprising 15 wt% to 25 wt% water.

12. The gel composition according to any one of claims 1 to 11, wherein the ionic crosslinking gelling agent comprises low acyl gellan.

13. The gel composition according to claim 1 or any one of claims 5 to 10, wherein the thickening agent comprises xanthan gum.

14. The gel composition according to claim 6 or any one of claims 7 to 13 when citing claim 6, wherein the hydrogen bond crosslinking gelling agent comprises agar.

15. The gel composition according to any one of claims 1 to 14, wherein the carboxylic acid comprises levulinic acid, and the levulinic acid is present in the range of 0.5 wt% to 2 wt%.

16. The gel composition according to any one of claims 1 to 15, wherein the carboxylic acid comprises lactic acid.

17. Use of the gel composition according to any one of claims 1 to 16 by heating the gel composition to vaporize the nicotine.

18. 0.5 to 2.5% by weight of nicotine, 70% to 80% by weight of glycerol, 0.5% to 3% by weight of an ionic crosslinking gelling agent, 0.5% to 3% by weight of a carboxylic acid, which is lactic acid or levulinic acid, and 15% to 25% by weight of water, the gel composition according to claim 1.

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