Aerosol product for finger disinfectant

Abstract

To provide an aerosol product relating to a disinfectant containing lower alcohol having 1 to 3 carbon atoms which can extinct bacteria and molds, and prevents flame spreading from an origin of fire if a kitchen, a dining table and the like are ignited.SOLUTION: An aerosol product for finger disinfectant includes an outer container, a finger disinfectant that is stored in the outer container and contains 20 w / v% to 65w / v% of lower alcohol having 1 to 3 carbon atoms, and an incombustible compression gas that is made to fill the outer container, in which when an ignited burner is left at a position away from a spray port for spraying the finger disinfectant by 15 cm, and the finger disinfectant is sprayed from the spray port so as to pass 1 / 3 of an upper part of flames of the burner, a flame length that is a length of the frame of the burner extending in a downstream direction when the frames of the burner is ignited and the finger disinfectant is sprayed is 0-20 cm.SELECTED DRAWING: Figure 1

Description

Technical Field

[0001] The present invention relates to an aerosol product containing a disinfectant for killing bacteria, mold, etc. adhering to a user's hands and fingers.

Background Art

[0002] Conventionally, in order to kill bacteria, mold, etc. adhering to a user's hands and fingers, disinfectants containing ethanol or the like as an active ingredient are known.

[0003] For example, in Patent Document 1, in Example 1, an aerosol product in which a stock solution composed of benzethonium chloride, 99% isopropyl alcohol, glycerin, and purified water is put into an aerosol pressure-resistant container and filled with carbon dioxide gas as a propellant, and in Example 2, an aerosol product in which a stock solution composed of benzalkonium chloride, 99% ethanol, and purified water is put into an aerosol pressure-resistant container and filled with carbon dioxide gas as a propellant is disclosed.

Prior Art Documents

Patent Documents

[0004]

Patent Document 1

Summary of the Invention

Problems to be Solved by the Invention

[0005] However, in the aerosol product of Patent Document 1, when spraying the stock solution of the disinfectant from the spray nozzle and attaching it to the user's fingers, even if it volatilizes slightly on the way from the spray nozzle to the fingers, in order to impart sufficient bactericidal and disinfecting properties, when a lower alcohol such as high-concentration isopropyl alcohol or ethanol is sprayed, since such a lower alcohol is a flammable liquid, if there is fire nearby, it will catch fire and spread from the fire source, posing a risk of fire. In particular, since the awareness of disinfection in the world has increased since the spread of coronavirus disease (COVID-19), and it is frequently used even in places where there is fire such as in the kitchen and at the dining table, there is concern about the spread of fire caused by ignition due to the use of disinfectants containing lower alcohols such as isopropyl alcohol and ethanol.

[0006] On the other hand, due to excessive fear of the risk of ignition, if the content of lower alcohols such as isopropyl alcohol and ethanol is too small, bacteria, mold, etc. cannot be killed in the first place, so it cannot be used as a disinfectant.

[0007] Therefore, in the present invention, regarding an aerosol product for a disinfectant containing a lower alcohol having 1 to 3 carbon atoms, an object is to provide an aerosol product for finger disinfectant that can kill bacteria, mold, etc., and further, even if there is fire nearby such as in the kitchen and at the dining table and it catches fire, it is difficult to spread from the fire source and is unlikely to cause a fire.

Means for Solving the Problems

[0008] 〔1〕That is, the present invention relates to an outer container, a finger disinfectant containing 20 w / v% to 65 w / v% of a lower alcohol having 1 to 3 carbon atoms accommodated in the outer container, and a non-flammable compressed gas filled in the outer container. , quaternary ammonium salts, acids, salts corresponding to said acids, and water, having a pH at 25 °C of 3.0 to 5.0 with nitrogen only a finger disinfectant, and a non-flammable compressed gas filled in the outer container said acid being phosphoric acidIt is provided with a burner ignited and placed at a position 15 cm away from a spray port for spraying the finger disinfectant. When the finger disinfectant is sprayed from the spray port so as to pass through the upper one-third of the flame of the burner, it catches fire with the flame of the burner, and the aerosol product for finger disinfectant is characterized in that the flame length, which is the length of the flame of the burner extending along the downstream direction of the spray, is 0 to 20 cm.

[0009] 〔2〕And

Figure 1

Advantages of the Invention

[0012] According to the present invention, for an aerosol product related to a disinfectant containing a lower alcohol having 1 to 3 carbon atoms, it can kill bacteria, mold, etc. Further, even if there is a fire nearby, such as in the kitchen or at the dining table, and it catches fire, it is difficult to spread from the source of the fire and difficult to cause a fire.

Brief Description of the Drawings

[0013]

Figure 2

Modes for Carrying Out the Invention

[0014] Hereinafter, embodiments of the aerosol product for finger disinfectant of the present invention will be described in detail. In the description, when there is a notation "~" indicating a range, it includes the upper and lower limits.

[0015] The outer container 1 is a member that is located on the outermost side and can be visually recognized by the user in the aerosol product for finger disinfectant of the present invention, and houses the finger disinfectant 2 inside. Since the inside of the outer container 1 is filled with a non-flammable compressed gas, it has pressure resistance so as not to break under a predetermined pressure such as a metal such as an aluminum alloy or a synthetic resin having a predetermined thickness. In the present embodiment, the outer container 1 has a hollow bottomed cylindrical shape with an opening at the upper part. The opening at the upper part is sealed by a mounting cup 3 as shown in FIG. 1. Further, in the finger disinfectant 2 described later, when it is acidic with a pH of 3.0 to 5.0 at 25 ° C., in order to prevent the outer container 1 from being perforated due to corrosion, the inside of the outer container 1 that comes into contact with the finger disinfectant 2 is preferably coated with a predetermined thickness with a polyolefin such as polyethylene, polypropylene, polyvinyl chloride, or a fluororesin such as polytetrafluoroethylene to have a coating layer.

[0016] Next, the finger disinfectant 2 contained in the outer container 1 will be described.

[0017] The lower alcohol having 1 to 3 carbon atoms in the present invention is an alcohol having 1 to 3 carbon atoms in the molecule such as methanol, ethanol, and isopropyl alcohol. By using the lower alcohol, it is possible to kill by destroying the cell membranes of bacteria, molds, etc., and prevent harm to the human body such as diseases caused by them. Also, with respect to viruses, the viruses can be killed by destroying the envelopes of the viruses and coagulating proteins such as enzymes.

[0018] The content ratio of the lower alcohol having 1 to 3 carbon atoms in the finger disinfectant 2 is preferably 20 w / v% to 65 w / v%, and more preferably 25 to 63 w / v%. When the content ratio of the lower alcohol having 1 to 3 carbon atoms is within this range, bacteria, molds, viruses, etc. can be killed and inactivated, and furthermore, it can exert a more effective effect on viruses in combination with an acid. Note that the concentration notation is the ratio of the number of grams (g) per 100 mL.

[0019] In the finger disinfectant 2 of the present invention, a quaternary ammonium salt can be blended. The quaternary ammonium salt generally has the chemical formula N + RX - (R: alkyl group, X - : chloride ion, etc.), and is a compound composed of a quaternary ammonium ion and a counter anion. Specific examples of the quaternary ammonium salt include benzalkonium chloride, benzethonium chloride, methylbenzethonium chloride, cetylpyridinium chloride, didecyldimethylammonium chloride, hexadecyltrimethylammonium bromide, tetraammonium bromide, etc. These quaternary ammonium salts can be used alone or in combination of two or more. Thus, the inclusion of the quaternary ammonium salt makes it easier to disrupt the cell membranes of bacteria, molds, etc., and can kill them. Furthermore, it becomes easier to disrupt the envelopes of RNA viruses with envelopes such as coronavirus (especially COVID-19), influenza virus, Ebola virus, human immunodeficiency virus, etc. and DNA viruses with envelopes such as herpes virus and smallpox virus, and they can be inactivated.

[0020] The content ratio of the quaternary ammonium salt is preferably 0.01 w / v% to 2.0 w / v%, more preferably 0.03 w / v% to 1.0 w / v% in the finger disinfectant 2. When the content ratio of the quaternary ammonium salt is within this range, it becomes easier to disrupt the cell membranes of bacteria and the like.

[0021] In the finger disinfectant 2 of the present invention, an acid can be blended. When the acid coexists with ethanol, a quaternary ammonium salt, etc., it destroys the capsid that protects nucleic acids, promotes the penetration of ethanol, a quaternary ammonium salt, etc. into cells, and furthermore, enhances the efficacy such as inactivation against a wide range of RNA viruses and DNA viruses regardless of the presence or absence of an envelope.

[0022] As the acid, specifically, organic acids such as citric acid, malic acid, acetic acid, boric acid, lactic acid, formic acid, oxalic acid, propionic acid, and inorganic acids such as phosphoric acid and sulfuric acid are preferred. These acids can be used alone, or two or more of them may be used in combination.

[0023] The content ratio of the acid is preferably 0.1 w / v% to 3.0 w / v% in the finger disinfectant 2, and more preferably 0.2 w / v% to 2.5 w / v%. When the content ratio of the acid is within this range, effects such as virus inactivation and bacteria killing can be achieved.

[0024] In the finger disinfectant 2 of the present invention, the salt of the acid can be blended. The salt of the acid is a salt corresponding to the above-mentioned organic acid or inorganic acid. Specifically, for example, when citric acid is used as the acid, the salts are sodium citrate, potassium citrate, calcium citrate, etc.; when malic acid is used, the salts are sodium malate, potassium malate, calcium malate, etc.; when phosphoric acid is used, the salts are sodium phosphate, potassium phosphate, calcium phosphate, etc. Thus, by including the salt corresponding to the acid, the finger disinfectant 2 has a pH within a predetermined range, and even if the lower alcohol or water having 1 to 3 carbon atoms in the finger disinfectant 2 is used for a long time and volatilizes slightly, a large change in pH is suppressed, so that the user can use it with a liquid property within a predetermined range.

[0025] The content ratio of the salt of the acid is preferably 0.1 w / v% to 3.0 w / v% in the finger disinfectant 2, and more preferably 0.2 w / v% to 2.5 w / v%. When the content ratio of the salt of the acid is within this range, the pH of the finger disinfectant 2 can be maintained within a predetermined range.

[0026] The water of the present invention is a solvent for making a lower alcohol having 1 to 3 carbon atoms, an acid, a salt of the acid, and a quaternary ammonium salt into a uniform solution. Specifically, as the water, water conforming to the Japanese Pharmacopoeia standard is preferable, for example, tap water, well water, etc., ordinary water, and purified water obtained by treating ordinary water by any one of distillation, ion exchange treatment using an ion exchange membrane, ultrafiltration treatment using an ultrafiltration membrane, or a combination thereof, and sterilized purified water obtained by sterilizing the purified water by heating or the like is preferable. And the blending ratio of water is the remainder excluding the lower alcohol having 1 to 3 carbon atoms, acid, salt of the acid, quaternary ammonium salt, etc. used in the present invention, and it is preferably 30 w / v% to 75 w / v%, and more preferably 32 w / v% to 65 w / v%.

[0027] In addition to the above-described components, the finger disinfectant 2 may optionally contain polyhydric alcohols such as glycerin, propylene glycol, butylene glycol, sorbitol, and moisturizing agents that are polysaccharides or their salts such as hyaluronic acid and sodium hyaluronate, thickeners such as hydroxyethyl methylcellulose and hydroxypropyl methylcellulose, fragrances, dyes, and the like. For example, adding a moisturizing agent can further prevent skin roughness.

[0028] The finger disinfectant 2 containing the above-described components preferably has a pH of 3.0 to 5.0 at 25°C, and more preferably 3.0 to 4.0, as the liquidity indicating the degree of acidity / alkalinity. When the pH of the finger disinfectant 2 is within this range, it is effective for killing bacteria and inactivating various viruses.

[0029] When the finger disinfectant 2 formulated in this way is sprayed from the spray port 71, the average particle diameter at 20 cm from the spray port 71 is preferably 15 to 150 μm, and more preferably 20 to 120 μm. When the average particle diameter is within this range, when it is sprayed from the spray port 71 of the aerosol product and adheres to the user's finger, even if the lower alcohol having 1 to 3 carbon atoms volatilizes on the way, it exhibits sufficient bactericidal and disinfecting properties, and since it does not contain an excessive amount of lower alcohol having 1 to 3 carbon atoms, even if it is ignited by a fire nearby, it can be made difficult to spread from the fire source. In addition, the average particle diameter is preferably measured by the laser diffraction / scattering method.

[0030] The non-flammable compressed gas of the present invention is filled in the outer container 1 together with the finger disinfectant 2, and at room temperature of about 10 to 30 °C which is usually used, ignition and combustion do not occur due to fire, and it is a gas in a state of having a pressure higher than atmospheric pressure inside the outer container 1. In the first embodiment, when the actuator 7 described later is pushed, the non-flammable compressed gas is discharged to the outside together with the finger disinfectant 2, and in the second embodiment, the bag body 11 is pressed. Specifically, the non-flammable compressed gas is preferably at least one selected from nitrogen, carbon dioxide, nitrous oxide, helium, and argon. When the non-flammable compressed gas is these gases, even if there is a fire near the user even if it is discharged from the spray port 71, it will not catch fire, etc., so the aerosol product for finger disinfectant of the present invention can be used safely.

[0031] In addition, as the pressure of the non-flammable compressed gas filled in the outer container 1 together with the finger disinfectant 2, it is preferably 0.10 MPa or more and less than 1.0 MPa at 35 °C, more preferably 0.2 to 0.9 MPa, and most preferably 0.6 to 0.85 MPa. When the pressure of the non-flammable compressed gas is within this range, the finger disinfectant 2 is smoothly discharged by the non-flammable compressed gas.

[0032] In the first embodiment, as shown in FIG. 1, the aerosol product is composed of an outer container 1, a finger disinfectant 2, a mounting cup 3, a stem 4, an elastic spring 5, a tube 6, an actuator 7, etc. The pressure of the finger disinfectant 2 and the non-combustible compressed gas contained in the outer container 1 is higher than that outside the outer container 1. Therefore, when the actuator 7 is pressed, the elastic spring 5 resists the biasing force and the stem 4 is also pressed, so that the stem hole 41 communicates with the inside of the bag body 11, and the finger disinfectant 2 and the non-combustible compressed gas are discharged to the outside through the tube 6 and the stem 4 from the spray port 71 of the actuator 7 via the bag body 11. Further, the diameter of the spray port 71 of the actuator 7 is preferably 0.05 to 1 mm, more preferably 0.1 to 0.7 mm, and most preferably 0.2 to 0.4 mm. When the diameter of the spray port 71 is within this range, the finger disinfectant 2 is discharged in a mist form by the non-combustible compressed gas.

[0033] Also, in the second embodiment, as shown in FIG. 2, the aerosol product has a bag body 11 housed in an outer container 1, and the finger disinfectant 2 is contained in the bag body 11. The bag body 11 is a flexible member. Since the bag body 11 is housed in the outer container 1, the finger disinfectant 2 contained in the bag body 11 does not directly contact the outer container 1, so that corrosion of the outer container 1 can be prevented when the finger disinfectant 2 contains an acid and shows acidity. Also, since it is constantly pressed by the non-combustible compressed gas filled in the space between the outer container 1 and the bag body 11, the finger disinfectant 2 contained in the bag body 11 can be used up to the end, and even if the aerosol product is turned upside down from the state of FIG. 1 so that the actuator 7 is at the bottom and sprayed, the finger disinfectant 2 is smoothly discharged. Further, when the finger disinfectant 2 contained in the bag body 11 is acidic, since it is stored at a pressure higher than atmospheric pressure, there is concern about deterioration or breakage of the bag body 11. As the bag body 11, at least on the surface in contact with the finger disinfectant 2, it is preferably a polyolefin such as polyethylene, polypropylene, or polyvinyl chloride, or a fluororesin such as polytetrafluoroethylene that is not hydrolyzed. Among polyethylenes, it is more preferably high-density polyethylene having a specific gravity of 0.92 to 0.96 and a load deflection temperature defined by JIS K7191-3 or the like of 130°C or lower. Also, of course, the above polyolefins and fluororesins may be formed as copolymers. And, in order to prevent the non-combustible compressed gas from flowing into the bag body 11, or to prevent the contained finger disinfectant 2 from leaking from the bag body 11 into the space S, other synthetic resins, metals such as aluminum, or metal oxides such as silicon dioxide and aluminum trioxide may be laminated on the outside of the above polyolefins and fluororesins such as polyethylene and polypropylene to form a multi-layer film of two or more layers.

[0034] And in the aerosol product of the second embodiment, similar to the first embodiment, it is composed of a finger disinfectant 2, a mounting cup 3, a stem 4, a resilient spring 5, a tube 6, an actuator 7, and the like. The bag body 11 accommodated in the outer container 1 is constantly pressed by the non-combustible compressed gas filled in the space S between the outer container 1 and the bag body 11. For this reason, when the actuator 7 is pressed down, the resilient spring 5 presses down the stem 4 against the biasing force, so that the stem hole 41 communicates with the inside of the bag body 11, and the finger disinfectant 2 pressed by the non-combustible compressed gas through the bag body 11 is discharged to the outside from the injection port 71 of the actuator 7 through the tube 6 and the stem 4. Also, similar to the first embodiment, the diameter of the spray port 71 of the actuator 7 is preferably 0.05 to 1 mm, more preferably 0.1 to 0.7 mm, and most preferably 0.2 to 0.4 mm.

Example

[0035] Hereinafter, the finger disinfectant 2 in the present invention will be specifically described. Note that the present invention is not limited to the following examples.

[0036] <Example 1> In a 200 ml Griffin beaker at room temperature of 20°C, 20 g of ethanol as a lower alcohol having 1 to 3 carbon atoms, 0.5 g of phosphoric acid as an acid, 0.25 g of trisodium phosphate as a salt corresponding to the acid, 0.1 g of a 50% concentrated benzalkonium chloride solution as a quaternary ammonium salt (0.05 g as benzalkonium chloride), 0.2 g of glycerin as a humectant, and the balance purified water were added, stirred, and a total of 100 ml of finger disinfectant was obtained.

[0037] <Example 3、 5, Comparative Examples 1 to 2> , Example 3 In Example 5, a lower alcohol having 1 to 3 carbon atoms, and, if necessary, an acid, a salt corresponding to the acid, and a quaternary ammonium salt were formulated as shown in Table 1, respectively, and in the same manner as in Example 1, a total of 100 ml of finger disinfectant was obtained.

[0038]

Table 1

[0039] Then, the above-mentioned finger disinfectant 2 was put into the outer container 1, nitrogen was enclosed as a non-combustible compressed gas so that the internal pressure became 0.8 MPa, and an actuator 7 with a spray port diameter of 0.3 mm was attached to produce an aerosol product in the second embodiment. Regarding the aerosol product containing the finger disinfectant 2 thus obtained, the performance was confirmed by the following evaluation method. Note that the aerosol product in the second embodiment can be produced and evaluated in the same manner.

[0040] 〔Sterilization and disinfection test〕 Regarding sterilization and disinfection, the effects on Escherichia coli and Staphylococcus in the finger disinfectant 2 sprayed from the aerosol product were confirmed. Specifically, first, assuming spraying on the finger when using the aerosol product, at a position 20 cm away from the spray port 71, various actuators 7 with different diameters of the spray port 71 were pressed down with a predetermined force and sprayed for about 1 second on about 10 5 colonies of bacteria smeared on the flat culture medium in the petri dish. Then, each culture medium was cultured at 35 °C for about 8 hours, and the number of bacteria was counted. Those with an efficacy of 99.9% or more in the ratio of the number of bacteria killed by contact with the finger disinfectant 2 to the initial number of bacteria smeared on the culture medium were evaluated as "◎", those with an efficacy of 99% or more and less than 99.9% were evaluated as "○", and those with an efficacy of less than 99% were evaluated as "×". At this time, "◎" and "○" were judged to be excellent as having sufficient sterilization and disinfection properties, and "×" was judged to be poor as having insufficient sterilization and disinfection properties.

[0041] 〔Flame length test〕 In accordance with the test of the spray flame length in the "Self - standard regulations related to the 'Test and Inspection Requirements for Aerosols, etc.'" (revised on April 25, 2017) by the Japan Aerosol Association, a burner ignited is placed statically at a position 15 cm away from the spray port 71 of the aerosol product. Press the actuator 7 with a predetermined force so that the upper one - third of the burner flame is passed through, and spray the finger disinfectant 2 from the spray port 71 of the aerosol product. At this time, it is ignited by the burner flame, and the length of the ignition flame extending from the burner flame along the downstream direction of the spray is measured. Since the flame is always swaying, it is measured whether it is within the range with marks at 5 - cm intervals as the background. In Table 1, those with the length of the ignition flame extending from the burner flame being 0 cm or more and less than 5 cm are denoted as "0 - 5", those with 5 cm or more and less than 10 cm are denoted as "5 - 10", those with 10 cm or more and less than 15 cm are denoted as "10 - 15", and so on. Those with the length of the ignition flame extending from the burner flame being less than 5 cm were evaluated as "◎", those with 5 cm or more and less than 20 cm were evaluated as "○", and those with 20 cm or more were evaluated as "×". At this time, "◎" and "○" were judged to be excellent as being difficult to spread from the ignition source, and "×" was judged to be poor as being easy to spread from the ignition source. Table 1 shows the results of the flame length test when the finger disinfectant 2 was sprayed.

[0042] As a comprehensive evaluation based on the results of these bactericidal and disinfectant tests and flame length tests, for each formulation, those evaluated as "◎" or "○" in both the bactericidal and disinfectant tests and the flame length tests were evaluated as "○" as those that can be actually used, while those evaluated as "×" in either one were evaluated as "×" as those that cannot be actually used.

[0043] As shown in Table 1, Example 1 , ratioEven if ethanol volatilizes during spraying, the aerosol product of Example 5 exhibits bactericidal and disinfectant properties against bacteria such as Escherichia coli and Staphylococcus aureus at a predetermined distance. It was also found that the length of the ignition flame extending from the flame of the burner, which is the source of fire, was less than 20 cm and it was difficult for the fire to spread even if it ignited, indicating that it could be actually used. However, for the aerosol product of Comparative Example 1, although the risk of very short flame length and spreading is extremely low when the amount of ethanol is less than a predetermined amount, due to the low ethanol content and the influence of ethanol volatilization during spraying, the bactericidal and disinfectant properties are not sufficient and it was difficult to actually use. Also ​ For the aerosol product of Comparative Example 2, when the amount of ethanol was more than a predetermined amount, the bactericidal and disinfectant properties were sufficient, but the flame length became long and the risk of spreading was high, making it difficult to actually use.

Explanation of Symbols

[0044] 1 ··· Outer container 11 ··· Bag body 2 ··· Finger disinfectant 3 ··· Mounting cup 4 ··· Stem 41 ··· Stem hole 5 ··· Elastic spring 6 ··· Tube 7 ··· Actuator 71 ··· Spray port S ··· Space

Claims

1. An outer container, a hand disinfectant contained in the outer container, containing a lower alcohol having 1 to 3 carbon atoms at 20 w / v% to 65 w / v%, a quaternary ammonium salt, an acid, a salt corresponding to the acid, and water, and having a pH at 25°C of 3.0 to 5.0, comprising only nitrogen as a non-combustible compressed gas filled in the outer container, when a burner ignited is placed at a position 15 cm away from a spray port for spraying the hand disinfectant, and the hand disinfectant is sprayed from the spray port so as to pass through the upper one-third of the flame of the burner, and the flame length, which is the length of the flame of the burner extending along the downstream direction of the spray, does not ignite the flame of the burner and is 0 to 20 cm, a hand disinfectant aerosol product characterized by this.

2. The hand disinfectant aerosol product according to Claim 1, wherein the acid is phosphoric acid.

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