Method and apparatus for measuring a measurement variable

Abstract

The object of the present invention is to improve a process, an apparatus, and a system for measuring a measurement variable. To this end, the measurement variable is measured in a measurement process based on an NV center as a quantum sensor. The NV center has multiple quantum states and is optically excitable based on the occupation of one of the quantum states, thereby becoming at least one excited state of the quantum states by the excitation light. The at least one excited state can decay with the emission of at least the NV center's emitted light. In the measurement process, the NV center is illuminated with excitation light, which has a time-period modulation, and the respective occupation probability and / or respective lifetime of the quantum states depend on the measurement variable and the excitation light. A phase shift is determined between the emission light of the NV center and the modulation of the excitation light, and based thereon, a measured value of the measurement variable is determined.

Description

[Technical Field]

[0001] The present invention is in the field of metrology, and in particular relates to a measurement method for measuring a measurement variable based on an NV center, an apparatus for measuring a measurement variable, a measurement head for measuring a measurement variable, and a system for detecting neuronal activity. [Background technology]

[0002] In metrology, the values ​​of measurement variables, i.e., for example, measured values, are typically acquired based on macroscopic measurements, in which case, for example, magnetic fields can be measured based on the induction of current, where the induced current depends on changes in the magnetic field.

[0003] For optical measurements, it is possible to use conventional fluorescent substances, e.g., molecules that fluoresce upon excitation - depending on the measurement variable. Furthermore, various materials are used whose optical properties depend on the respective measurement variable, where the (measured) value of such optical property or its change is captured optically - e.g., electro-optically - and the measured value of the measurement variable is determined from the (measured) value of the optical property based on the dependence of said optical property on the measurement variable.

[0004] In addition to macroscopic measurement techniques, measurement techniques based on quantum sensor technology are increasingly being applied. In this regard, for example, nanodiamonds (or more generally mesoscopic solid-state elements) with nitrogen-vacancy centers as color centers have high brightness, i.e., particularly high light emission, when optically excited, and also have photostability, i.e., particularly low bleaching. Furthermore, the emitted light from such nitrogen-vacancy centers depends on the magnetic field effective there, as well as on further influencing factors, such as microwave radiation, and this dependence is determined quantum mechanically, thereby achieving high measurement accuracy and reproducibility—even at room temperature. Based on the magnetic field dependence of the fluorescence or phosphorescence (or more generally, luminescence, hereinafter simply referred to as "fluorescence" and corresponding to fluorescent substances or fluorophores) of nitrogen-vacancy centers, or more generally, NV centers, the effective magnetic field in the case of NV centers can be determined by changes in fluorescence intensity. Summary of the Invention [Problem to be solved by the invention]

[0005] There is a need for improved methods, devices, and systems for measuring measurement variables, and in particular for increasing the measurement accuracy and / or repeatability of such measurements to reduce measurement artifacts and / or make such measurements more reliable and / or more efficient. [Means for solving the problem]

[0006] The present invention fulfills this need in each case by a measurement method for measuring a measurement variable based on an NV center, a device for measuring a measurement variable, a measurement head for measuring a measurement variable, and a system for detecting neuronal activity according to the teaching of one of the main claims in each case. The dependent claims relate in particular to advantageous embodiments, developments and variants of the invention.

[0007] A first aspect of the present invention relates to a measurement method for measuring a measurement variable based on an NV center. The NV center has a plurality of quantum states and can be optically excited by excitation light depending on the occupation of one of the quantum states, thereby becoming at least one excited state of the quantum states. In this case, the at least one excited state can decay with the emission of at least an emitted light from the NV center. The measurement method includes irradiating the NV center with excitation light, the excitation light having a time-period modulation, and each occupation probability and / or each lifetime of the quantum states depends on the measurement variable and the excitation light. The measurement method further includes determining a phase shift between the emitted light from the NV center and the modulation of the excitation light. The measurement method further includes determining a measurement value of the measurement variable based on the phase shift.

[0008] Within the meaning of the present disclosure, "NV center" should be understood to mean at least one color center, where the color center can be optically excited by excitation light depending on a magnetic field or some other measured variable effective at said color center, and emitted light can be emitted by the excited color center. Such color centers can be defects in the matrix structure, in particular in the (possibly crystalline) solid state. Furthermore, the intensity of the emitted light can depend on resonant microwave absorption, where the resonant microwave absorption depends on the magnetic field and / or other measured variables at the color center. Furthermore, such NV centers can be nitrogen-vacancy centers in the diamond lattice, which is the subject of current research, e.g., so-called [NV] - It can be the center. Such [NV] - In the case of centers, models currently take as their basis a multi-electron system described as a three-level system with a triplet ground state, an excited triplet state, and at least one intermediate state—specifically a singlet state—that is energetically between the ground and excited states (or two intermediate states, e.g., Doherty, Marcus W.; Manson, Neil B.; Delaney, Paul; Jelezko, Fedor; Wrachtrup, Joerg; Hollenberg, Lloyd CL (2013-07-01) "The nitrogen-vacancy color center in diamond". Physics Reports. The nitrogen-vacancy color center in diamond. 528 (1):1-45). Furthermore, such [NV] - In the case of NV centers, electron spin resonance can be excited between multiple energetically distinct states within the triplet ground state, which differ in energy due to spin interactions and possibly also due to magnetic fields acting on the NV center. Microwave radiation of a suitable frequency can be used to excite the electron spin resonance, such that the energy from the microwave radiation raises the electron system from a lower energetic state of the triplet ground state to a higher energetic state of the triplet ground state.

[0009] One advantage of the dependence of the lifetimes and / or occupation probabilities of at least some of the quantum states on the measurement variables is, in particular, that this allows the NV center to be used as a quantum sensor for measuring the measurement variables. In this case, in addition to or as an alternative to the dependence on the measurement variables, some of the quantum states may also be manipulated by excitation light, thereby advantageously influencing the states—i.e., in particular the occupation probabilities of certain quantum states—with the excitation light in a manner that increases their dependence on the measurement variables. One advantage of NV centers as quantum sensors is, in particular, that their properties are specified quantum mechanically, thereby making it possible to achieve high measurement accuracy, measurement reproducibility, and / or sensitivity. Such quantum sensors allow for a reduced influence of the measurement variables measured by the measurement method or corresponding (measurement) device—for example, compared to macroscopic measurements, in which the object to be examined and / or the measurement variables to be measured on this object interact with the macroscopic sensor, possibly.

[0010] One advantage of determining the phase shift and measurement value based on theory is in particular that the phase shift is not affected by fluorescence (brightness / intensity) fluctuations - e.g. due to (random) fluctuations of the excitation light - and / or disturbances and / or noise have a smaller effect on the phase shift than on the fluorescence intensity (and thus on measurements based on intensity determination), which advantageously allows for more reliable measurements and / or increases the measurement accuracy and / or the signal-to-noise ratio and thus the sensitivity.

[0011] One advantage of excitation light modulation may in particular be that for modulation purposes, a (relatively) small and / or continuous change in the excitation light is sufficient - e.g. compared to pulsed excitation light, which either has at least substantially a maximum intensity or is off - which advantageously makes the measurement method easier to carry out and / or the corresponding (measurement) device simpler to implement and thus more reliable. Furthermore, modulation may make it possible to reduce the intensity of the excitation light, in particular the maximum intensity and / or intensity changes, and thus reduce influences and / or (measurement) errors - e.g. due to non-linear effects.

[0012] Measurements based on excitation light and emitted light, ie for example optical measurements, make it possible to determine measurement values ​​without physical contact, for example between a control device, a light source and / or a sensor device, and the object to be examined.

[0013] In some embodiments, the diamond has a nitrogen-vacancy center as the NV center. In some variations thereof, the mesoscopic solid-state element comprises diamond. Furthermore, in some variations, the diamond is implemented as a mesoscopic solid-state element, for example, as a nanodiamond. In some further variations, the diamond is implemented as a macroscopic solid-state element, for example, as a macroscopic single crystal, or as a polycrystalline diamond, for example, as a diamond platelet or a diamond rod, and / or having, for example, an extent of at least 100 μm along one axis, or, for example, a weight of at least 10 mg.

[0014] One advantage of nitrogen-vacancy centers may in particular be that their properties, particularly their quantum mechanical properties, with regard to fluorescence, e.g. when implemented as (nano)diamonds, are stable even at room temperature (i.e. e.g. around 20°C, e.g. in the temperature range 200K-500K), thereby allowing measurements over a wide temperature range and / or at temperatures customary in production processes, in the industrial sector and / or in the medical sector, e.g. in surgery.

[0015] Within the meaning of the present disclosure, a "mesoscopic solid-state element" should be understood to mean at least one object composed of a solid-state material having a spatial extent—i.e., for example, a maximum diameter—of less than 1 μm. Furthermore, the spatial extent can be generally greater than 1 nm. Such a mesoscopic solid-state element can be a matrix structure composed of atoms or molecules, i.e., for example, a crystalline solid. In the case of NV centers in a mesoscopic solid-state element, for example, the mesoscopic solid-state element contains or forms at least the above-mentioned NV centers. In this case, the NV centers can be defects in the matrix structure of the mesoscopic solid-state element. Furthermore, the mesoscopic solid-state element can contain further NV centers. Such a mesoscopic solid-state element can be, or can contain, for example, nanodiamonds. In this case, such nanodiamonds contain nitrogen-vacancy centers as NV centers, i.e., for example, [NV] - Center or [NV] 0 NV centers. Furthermore, such nanodiamonds may contain ST1 or "Stuttgart 1" color centers as NV centers. Furthermore (more generally), mesoscopic diamond matrices may be such mesoscopic solid-state elements, containing diamond matrix color centers as NV centers. Furthermore, such mesoscopic solid-state elements may be produced from, for example, 4H SiC, and may contain, for example, a solid-state matrix made of 4H SiC, in particular a crystal lattice. In this case, such mesoscopic solid-state elements made of 4H SiC may contain, as NV centers, for example, so-called "VcVsiDi vacancies" or so-called "NV nitrogen vacancies" or so-called "hexagonal lattice site silicon vacancies (V)" in the crystal lattice. Si) (see, for example, NATURE COMMUNICATIONS|(2019)10:1954|https: / / doi.org / 10.1038 / s41467-019-09873|High-fidelity spin and optical control of single silicon-vacancy centers in silicon carbide).

[0016] One advantage of mesoscopic solid-state elements containing NV centers—i.e., embodied as defects in the solid-state matrix of the mesoscopic solid-state element, e.g., a diamond matrix—may be that the NV centers have high photostability and / or high brightness—i.e., high intensity of emitted light, especially at a specific intensity of excitation light—and / or that the mesoscopic solid-state elements shield the NV centers from external fluctuations—e.g., to a greater extent than is the case with conventional fluorophores, such as individual fluorescent molecules—which can increase efficiency and / or reliability and simplify application. Furthermore, such mesoscopic solid-state elements typically exhibit low interactions with materials, e.g., biological materials, and thus have high (bio)compatibility, which advantageously reduces (unwanted) influences of the material to be examined, e.g., tissue, and thus simplifies application, e.g., in the case of surgery.

[0017] Furthermore, increased (bio)compatibility allows for longer measurement times and thus for example increased accuracy and / or reliability. Furthermore, other applications, i.e. not specifically for biomaterials, can also be improved, where such NV centers as quantum sensors allow for example to investigate, for example, specific portions (proportions) of a product, e.g., a chemical substance or a workpiece, i.e., to identify material properties by identifying a measured variable related to the material properties.

[0018] A second aspect of the present invention relates to an apparatus for measuring a measurement variable. The apparatus includes a spatial region in which one or more NV centers are located. Additionally, the apparatus includes a light source that irradiates the spatial region with excitation light having a time-period modulation, such that when one or more NV centers are located within the spatial region, one or more of the NV centers are optically excitable. Additionally, the apparatus includes a sensor device configured to capture radiation light emitted by one or more of the NV centers. Furthermore, the apparatus includes a control device configured to cause the light source to irradiate at least one of the NV centers with the time-period modulated excitation light, determine a phase shift between the modulation of the radiation light and the excitation light based on the radiation light captured by the sensor device, and, based thereon, determine a measurement value of the measurement variable for the at least one NV center.

[0019] Correspondingly, possible advantages, embodiments or variants of the first aspect of the invention are also applicable to an apparatus for measuring a measurement variable, in which case the apparatus may for example be configured to perform a method according to the first aspect of the invention. An apparatus for measuring a measurement variable may also be referred to as a "measurement apparatus".

[0020] A third aspect of the present invention relates to a measurement head for measuring a measurement variable. The measurement head comprises a housing, an NV center, a light source or optical coupling element, and a sensor device or, possibly, a further optical coupling element. In some variations using a light source, the light source is configured to generate excitation light and irradiate the NV center with the excitation light. Alternatively, in some variations, for example, in some variations without a light source for excitation light, the optical coupling element of the measurement head is connectable to a light guide arranged outside the housing and configured to irradiate the NV center with the emitted excitation light via the light guide. In some variations using a sensor device, the sensor device is configured to capture radiation light emitted by the NV center. Alternatively, in some variations, for example, in some variations without a sensor device for capturing radiation light, the optical coupling element of the measurement head is configured to guide radiation light emitted by the NV center to a light guide arranged outside the housing. Furthermore, the NV center and, if possible, the sensor device or, if possible, the light source are also arranged in a housing, and the housing is sealed.

[0021] Correspondingly, any possible advantages, embodiments or variations of the previous aspects of the invention are applicable to the measurement head as well.

[0022] One advantage of a sealed housing and an NV center located within the housing may in particular be that it allows the NV center to be protected from, for example, liquids or gases, thereby making measurements using the measurement head easier and / or more reliable.

[0023] A fourth aspect of the present invention relates to a system for detecting neuronal activity, where neuronal activity generates a magnetic field in the neuronal environment. The system includes a measurement head according to the third aspect of the present invention. The system further includes a light source generating excitation light with a time-period modulation, whereby the NV center of the measurement head can be optically excited; a sensor device configured to capture the emitted light emitted by the NV center; and a control device. In this case, the lifetime and / or occupancy probability of at least one excited state of the quantum state of the NV center can be modified by the strength and / or orientation of the magnetic field at the NV center. Additionally, the control device is configured to cause the light source to illuminate the NV center with the time-period modulated excitation light, determine a phase shift between the modulation of the emitted light and the excitation light based on the emitted light captured by the sensor device, and, based thereon, determine a measurement value of the magnetic field at the NV center, thereby detecting neuronal activity based on the magnetic field caused by the neuronal activity when the NV center is located in the neuronal environment.

[0024] Correspondingly, possible advantages, embodiments or variants of the previous aspects of the invention are equally applicable to the system, which may for example be configured to carry out the method according to the first aspect of the invention.

[0025] In some variations, the system can be advantageously used in surgery - neurosurgery - and can therefore be configured for such use. One advantage of the synergistic combination of the determination of NV centers and measurements based on the determination of phase shifts - i.e., for example, of magnetic fields and thus neuronal activity - is that it can achieve high sensitivity to possible neuronal activity, thereby making it possible to identify active neurons and to avoid or at least reduce damage to active neurons - resulting, for example, from cutting with a scalpel.

[0026] Further advantages, features and applicability will be apparent from the following detailed description and / or figures of exemplary embodiments.

[0027] The invention will be explained in more detail below on the basis of advantageous exemplary embodiments with reference to the figures. Identical elements or component parts of the exemplary embodiments are substantially identified with identical reference numerals, unless stated otherwise or the opposite is clear from the context. In this respect, the figures show, partly diagrammatically: [Brief explanation of the drawings]

[0028] [Figure 1] A model of the [NV]-center is shown. [Figure 2] The energy diagram of the NV center is shown. [Figure 3] 1 illustrates a measurement device according to one embodiment. [Figure 4] 1 shows a flow diagram of a measurement method according to one embodiment. [Figure 5] 1 illustrates a system for detecting neural activity using a measurement head according to one embodiment. DETAILED DESCRIPTION OF THE INVENTION

[0029] The figures are schematic diagrams of various embodiments and / or exemplary embodiments of the present invention. The elements and / or component parts shown in the figures are not necessarily drawn to scale. Rather, the various elements and / or component parts shown in the figures are presented in a manner that will make their function and / or purpose clear to one skilled in the art.

[0030] The connections and couplings between functional units and elements shown in the figures can also be implemented as indirect connections or couplings. In particular, data connections can also be implemented as wired or wireless, i.e., radio wave, connections. Furthermore, for the sake of clarity, certain connections, e.g., electrical connections for supplying energy, may not be shown. Furthermore, optical connections, e.g., between optical elements, which may in particular be shown as straight light beams, can also, in some variants, be implemented by optical elements such as light guides and / or mirrors for deflecting light beams, and for the sake of clarity, such connections are not necessarily shown.

[0031] Figure 1 shows, for example, the [NV] structure without the surrounding diamond lattice. - The atomic structure of an NV center, such as a nitrogen-vacancy center, is shown schematically by a ball-and-stick model of the center (140). In this case, three carbon atoms 146 are located at three positions in the diamond lattice, while the lattice position (direct / nearest neighbor) next to these three carbon atoms 146 is a vacancy 144 (vacancy: V)—i.e., this lattice position is unoccupied—and the lattice position (direct / nearest neighbor) next to that is a nitrogen atom 142 (nitrogen: N) instead of a carbon atom. Furthermore, FIG. 1 shows the vector of the external magnetic field 80, as well as the axis of the NV center 148—with respect to which the total spin of the multi-electron system of the NV center is defined. It goes without saying that, in this specification, the magnetic field effective therein may be the magnetic field due to the magnetic moments of the nuclei of the electrons of the multi-electron system, or these fields may be superimposed, in which case—unless these additional magnetic moments are referred to separately—within the meaning of the present invention, the "magnetic field effective therein" should be understood to mean the magnetic field that arises there, i.e., at each NV center, due to the external magnetic field.

[0032] Figure 2 shows the current modeling (see, e.g., Rogers, LJ; Armstrong, S.; Sellars, MJ; Manson, NB (2008) "Infrared emission of the NV center in diamond: Zeeman and uniaxial stress studies" New Journal of Physics. 10(10):103024) (see, e.g., Doherty, Marcus W.; Manson, Neil B.; Delaney, Paul; Jelezko, Fedor; Wrachtrup, Joerg; Hollenberg, Lloyd CL (2013-07-01) "The nitrogen-vacancy color center in diamond" Physics Reports. The nitrogen-vacancy color center in diamond. 528(1):1-45) of the [NV] -1 shows an energy diagram 40 of an NV center such as a center. The multi-electron system of an NV center has a triplet ground state |g>, an excited triplet state |e>, and two intermediate states |ze> and |zg> that are energetically between the ground state |g> and the excited state |e>. Two of the electrons in the multi-electron system can be oriented parallel or antiparallel with respect to spin in the triplet ground state, and therefore the multi-electron system has a total spin of +1(m s =+1) or -1(m s =-1) or total spin 0 (m s = 0). Due to spin interactions, electrons with step winches +1 or -1 have higher energy levels than in the antiparallel orientation with spin 0. In addition—not shown in FIG. 2—m s =+1 and m s The energy levels at m = -1 can differ from each other due to, for example, interactions with the magnetic moments of the nuclei (see hyperfine structure), and this splitting, i.e., m s =+1 and m s The difference between the energy levels at =-1 is usually m s Energy levels and m when =0 s =+1 / m s = -1.

[0033] 2, the emission of radiation by the NV center 140 for the energy levels according to FIG. 1 and / or according to FIG. 2 and the dependence of the intensity of the emitted radiation on the resonant microwave absorption and the magnetic field at the NV center can be elucidated as follows: With excitation light 46 having sufficient energy per photon, i.e., for example, a green laser having a wavelength generally less than 532 nm, such as having a wavelength of 515 nm as shown, [NV] - The center can be optically excited from the ground state |g> to the excited state |e> (perhaps going first to the vibronic band and then from there to the excited state), and the overall spin of the many-electron system is maintained, i.e., for example, m s When the ground state |g> where =+1 is excited, the corresponding excited state is m s=+1. The NV center then converts to the corresponding triplet ground state, i.e., m s =+1 to m s = +1, and in this respect, for example, [NV] - In the case of the center, a photon at 637 nm can be emitted, i.e., for example, red radiation 56. This transition is also called a radiative transition or an optical transition, and the light emitted in this case (radiation / fluorescence) is usually detected optically.

[0034] In addition to this radiative transition, further transitions via intermediate states |ze> and |zg> are also possible, where, for example, a photon with a longer wavelength |zg> transitions to |ze>, i.e., for example, [NV] - In the case of the center, a photon of 1042 nm is emitted. Other models are based on only one intermediate state, and therefore no corresponding photon is emitted. Therefore, in these transitions, no photon is emitted, or at least no photon with a different wavelength, especially a longer wavelength 58, occurs; these transitions are also called non-radiative transitions. In these non-radiative transitions, the total spin of the multi-electron system is not necessarily maintained, and the m of the excited triplet state |e> s =+1 or m s =-1 from the excited state to the triplet ground state, m s The rate or probability of transitioning to the state where m = 0 is s = 0 to m s = +1 or -1. Further transitions through the intermediate states |ze> and |zg> compete with radiative transitions. Therefore, the NV center has a spin m s = 0, then spin m s =+1 or m s The radiation emitted is greater than that in the case of m = -1, because s =+1 or m s This is because transitions through intermediate states are (relatively) more frequent when m = -1. s =+1 or m sThe lifetime of the excited state for =-1 is the total spin m s = 0. Furthermore, in the case of the NV center, repeated excitation leads to m s It is possible to increase the probability of occupancy of the ground and / or excited states where m = 0, because through further transitions s = 0, and possibly after a new excitation, m s = 0) is more likely to be obtained in the excited state |e>) - also known as spin polarization.

[0035] A specific measurement - e.g., m s = 0, and |g> and m s = ±1, or the energy difference between |g> and m s =0 and |e> and m s = ±1, m s It is possible to increase the probability of occupancy of ground and / or excited states where [NV] = +1 or -1. - In the center (without external magnetic field), microwave radiation 48 with a frequency of approximately 2870 MHz produces m s =0 from |g> to m s The transition to one of the ground states where m = ±1 can be resonantly excited, i.e., electron spin resonance—i.e., within the meaning of the present disclosure, in particular m s =0 from |g> to m s = +1 or -1. In a broader sense, electron spin resonance can also be understood to mean such excitation with a change in the (external) magnetic field and measurement of the field-dependent absorption of microwave radiation (see for example https: / / de.wikipedia.org / wiki / Elektronenspinresonanz).

[0036] The multi-electron system has a total spin m s and a first spin quantum number m s =0, and the second spin quantum number m s= +1, and the third spin quantum number m s = -1 for NV centers - e.g. [NV] - In the case of the central etc., the external magnetic field is applied, m s = +1 and m s = -1 (correspondingly, the same is true for m s (This also applies to the excited triplet state |e> where = ±1.) Therefore, m s =0 from |g> to m s For a transition to |g> where =-1, m s =0 from |g> to m s =+1, microwave radiation of a different frequency is required than for the transition to |g>, i.e., for example, m s Electron spin resonance in the case of m = +1 occurs at at least one resonance frequency, s Electron spin resonance in the case of =-1 occurs at a further resonance frequency.

[0037] [NV] - When the center is irradiated with microwave radiation having a frequency of approximately 2870 MHz (initially without an external magnetic field), m s =±1, resulting in a decrease in fluorescence, i.e., the emitted radiation 56 and / or the lifetime of the excited triplet state |e>—e.g., m s = 0, which has a shorter lifetime than the excited triplet state s = ±1. The external magnetic field 80 acting on the NV center 140 shifts the frequency required for electron spin resonance in each case, resulting in m s The increase in the probability of the state where =±1 becomes smaller or no longer increases upon irradiation with microwave radiation having a frequency of approximately 2870 MHz, and therefore the lifetime of the excited triplet state does not decrease or increases again, and also a shortening of the lifetime occurs at at least one resonant frequency and further resonant frequencies.

[0038] Therefore, for an NV center with a many-electron system whose total spin is at least two spin quantum numbers, the lifetime of the excited triplet state |e> is at least one spin quantum number m s =±1 depends on the specific measures to increase the occupation probability of the states, i.e., the frequency and field strength of the incident microwave radiation, the excitation light, e.g., due to spin polarization, and the (external) magnetic field effective at the NV center.

[0039] Furthermore, the lifetime of at least one of the excited states of the NV center may depend on further variables, such as, for example, the material stress of the (e.g., mesoscopic) solid-state element comprising the NV center or the electric field effective at the NV center, and it is therefore possible to measure them as variables measured by the NV center as a quantum sensor - i.e., in particular based on the dependence of the lifetime of |e> on them. Furthermore, certain variables, such as, for example, the local density of states or magnetic fields in the environment of the NV center - for example, a sufficiently strong magnetic field having, for example, at least 10 mT and / or an orientation that deviates from the axis 148 such that the axis 148 no longer provides a good quantum number for the total spin, i.e., for example, the total spin about said axis no longer represents an eigenstate - may be determined by the dependence of the lifetime of |e> on them. s The probability of occupancy of the states where = -1, 0, or +1 can be varied (e.g., by mixing states), so that the lifetime of the excited state also depends on such variables, which can be identified as the variables measured by the lifetime.

[0040] [NV] - For centers, the lifetime of the excited state |e> (depending on the total spin) typically ranges from about 10 ns to several ms.

[0041] FIG. 3 shows a schematic diagram of a measurement device 200 for measuring a measurement variable according to one embodiment of the present invention.

[0042] 3 shows the material portion 20 being examined based on the measurement, which does not necessarily belong to the apparatus 200. In an exemplary embodiment, the material portion 20 can be a metal workpiece, for example, from a 3D printing, stamping, or casting process.

[0043] In one exemplary embodiment, the measurement apparatus 200 comprises a sensor device 250, in which a coil array 280 is arranged, and in which a diamond platelet 104 is arranged, or which captures emitted light on at least one side, and also in the spatial region 204, the diamond platelet 104 has a plurality of NV centers 140 (only one NV center is shown for simplicity).

[0044] In some variants, the NV centres - as assumed in the following discussion - are [NV] in each case. - Further, in some variations, the sensor device 250 includes an image sensor, where the sensor device 250 is configured to capture the emitted light of the NV center 140 with imaging and time resolution.

[0045] In an exemplary embodiment, the measurement apparatus 200 further comprises a light source 240, e.g., a laser device 240, configured to generate continuous excitation light such that the NV center 140 can be optically excited and, upon excitation, emits emitted light, e.g., magnetic field dependent. Additionally, the measurement apparatus 200 comprises an electro-optical modulator 246, where a beam path passes from the laser device 250 to the NV center 140 and through the electro-optical modulator 246.

[0046] In an exemplary embodiment, the measurement apparatus 200 further comprises a lock-in amplifier 216 and a control device 210. The control device 210 is configured to cause the light source 240 to continuously generate the excitation light. Furthermore, the control device 210 is configured to generate a modulation signal and thereby control the electro-optical modulator 246, where the electro-optical modulator 246 is configured to modulate the intensity of the excitation light in accordance with the modulation signal. In this regard, for example, the modulation signal can have a sinusoidal profile, a chirp profile, or a square or sawtooth profile, and the intensity of the excitation light after passing through the electro-optical modulator 246 can also have a corresponding sinusoidal profile, a chirp profile, etc. In this case, in some variations, the modulation signal consists of one or more frequencies in the range of 10 kHz to 100 MHz, and for example, the square or sawtooth profile is a superposition of multiple sinusoidal profiles of different frequencies. In this case, the frequency range—i.e., for example, the frequency range—is chosen such that the frequency of modulation is shorter than the lifetime of the excited state of the NV center and therefore the duration of each period is greater than the lifetime of the excited state of the NV center, in particular at least 10 times greater—for example, greater than 10 ns, In addition, the time resolution during acquisition by the sensor device 250 is at least 5 times higher than the duration of each period.

[0047] Furthermore, the control device 210 is configured to determine a phase shift between the modulation of the excitation light and the emitted light by a lock-in amplifier 216. In some variations, the control device 210 is configured to control the sensor device 250 by the lock-in amplifier 216 such that the sensor device 250 is sensitive to the determined phase shift. In addition, the control device 210 is configured to determine, perhaps image at each position of the NV centers 140, a measurement variable—i.e., each magnetic field at each NV center 140—based on the phase shift. In this regard, for example, a sufficiently strong magnetic field may be [NV] - The lifetime of the excited triplet state at the center can be reduced, thus reducing the phase shift.

[0048] In some alternative variations, the measurement device 200 includes a nanodiamond 104 having an NV center 140 instead of a diamond platelet. In this case, the nanodiamond 104 can be positioned within a material, such as a liquid, or near a material, such as the material portion 20, such that the NV center 140 interacts with the local density of states of the material and changes its occupation probability and / or lifetime. In this regard, in some variations, for example, the surface of the nanodiamond can be functionalized with a dye, and the color of the dye—i.e., for example, the wavelength range absorbed by the dye—depends on its chemical environment. In this case, when the wavelength of the emitted light is within the wavelength range absorbed by the dye, the lifetime of at least one excited state of the NV center can be shortened by Förster resonance energy transfer, resulting in a corresponding reduction in the phase shift.

[0049] Some exemplary embodiments include, for example, [NV] - Although described with respect to the center and its properties, e.g., the lifetime of the excited triplet state, which depends on the total spin, other color centers can also be used as NV centers if they have at least one optically excitable state that decays with the emission of emitted light, possibly in addition to other decay routes, where the lifetime of this at least one excited state or its excitability, i.e., its occupancy probability upon irradiation with excitation light, depends on the measurement variables to be specified in each case. In this regard, for example, a phase shift between the excitation light and the emitted light can also result from a longer-lived ground state, including upon excitation with excitation light.

[0050] In an exemplary embodiment, control device 210 is further configured to generate, via coil array 280, a magnetic field that generates eddy currents in material portion 20. In this case, coil array 280 can be configured to generate a magnetic field such that eddy currents are generated at least substantially at different material depths that are variable by control of the portion by control device 210. In this case, the generated eddy currents and the resulting magnetic fields—identified as measurement variables—can allow conclusions to be drawn about the quality of material portion 20. In this regard, for example, cracks in the material portion reduce the eddy currents that are generated.

[0051] In some variations of the exemplary embodiment, the measurement apparatus 200 includes an actuator device 220 that can be connected to the material portion 20 such that the actuator device 220 can change the orientation of the material portion 20 and / or move the material portion 20 along the sensor device 250 and the NV center 140. In this case, the control device 210 can be configured to move the material portion 20 with the actuator device 220 to position different regions of the material portion 20 relative to the sensor device 250 and / or the NV center 140 and identify a measurement variable, i.e., for example, a magnetic field, in each region of the material portion 20.

[0052] FIG. 4 shows a flow diagram of a measurement method 400 for measuring a measurement variable based on NV centers, ie, a measurement method 400 according to one embodiment of the present invention.

[0053] In one exemplary embodiment, the measurement method is used as a quantum sensor [NV] - Based on the center, here, in particular the (external) magnetic field acting on this NV center or at least the field strength of said magnetic field is specified as a measurement variable.

[0054] In one exemplary embodiment, method 400 includes method steps 430, 432, 440, 442, 450, 460, 464, 466, and 470, as well as method conditions 410 and 412. Method 400 begins at method start 402 and ends at method end 404.

[0055] In method step 430, [NV] - The center is irradiated with microwave radiation.

[0056] In this case, in method step 432 iteratively (as part of method step 430) determines whether a particular frequency is within a predetermined frequency range, e.g., [NV] - In the center, microwave radiation having a frequency selected from 2.5 GHz to 3.2 GHz is generated, [NV]. -radiates to the center.

[0057] In method step 440, at each frequency of microwave radiation, [NV] - The center is illuminated with excitation light.

[0058] In this case, in method step 442 iteratively (as part of method step 440), excitation light is generated—for example by a light source, such as light source 240 with respect to FIG. 3—and values ​​according to a sinusoidal profile are selected for the intensity of the excitation light. In this case, in some variations, the excitation light is first generated at an at least approximately consistent intensity and then attenuated according to the respectively selected value for intensity—for example by an acousto-optic modulator or an electro-optic modulator, such as electro-optic modulator 246 with respect to FIG. 3. Alternatively or additionally, excitation light having an intensity corresponding to the respectively selected value has already been generated—for example by a laser diode, the electrical energy supply of which is correspondingly modulated.

[0059] Additionally, in method step 450, the intensity of emitted light at the NV center is captured in a magnetization-dependent manner, where the time-dependent capture has a time resolution higher than the period duration of the sinusoidal profile. In this regard, for example, for each selected value of the intensity of the excitation light, multiple intensities of emitted light are captured in the time profile, allowing the intensity change of the emitted light to be resolved, e.g., when the intensity of the excitation light changes from a previously selected value to a value selected in a current iteration.

[0060] The method condition 410 includes checking whether further values ​​should be selected (in further iterations) for the intensity of the excitation light (for each frequency of microwave radiation). In this regard, the sinusoidal profile can be modeled, for example, by a time profile of several discrete values ​​- for example, so-called "samples" - and the sinusoidal profile can be repeated over several period durations. In the case of a sinusoidal profile with a frequency of 10 MHz and accordingly a period duration 1 / (10 MHz) = 100 ns, each period duration can be described by 10 time-discrete values, each having a length of 10 ns. Furthermore, the sinusoidal profile can be repeated over 100 periods and thus a total time of 100 us, thereby allowing, for example, high precision in determining the phase shift. When further values ​​should be selected - <y>If so, the method 400 continues to method step 442, where a further chronologically subsequent value is selected. <n>, the method 400 continues to method step 460 .

[0061] In method step 460, the phase shift between the intensity of the excitation light and the intensity of the time-dependent captured emitted light is determined at each microwave frequency (ie, at each frequency of microwave radiation).

[0062] In this case, as explained earlier, [NV] - The center contains a multi-electron system with a triplet ground state |g> and an excited triplet state |e>, which have a total spin m s and m can have spin quantum numbers −1, 0, and +1, respectively, and in each case, one of the triplet ground quantum states can be optically excited to preserve its spin—for example, by excitation light having a wavelength of 515 nm—to form an excited triplet quantum state having the same total spin. In addition, m can be selected as at least one excited state having a first spin quantum number (i.e., 0). s The lifetime of the state |e> where |e = 0 is m as the second excited state with the second spin quantum number (i.e., +1). s = +1 and has a third excited state m s = -1. In this case, the occupation probability of all three excited states of the excited triplet state |e> depends on the excitation light due to the possibility of optical excitation. In addition, the ratio of the occupation probability of the quantum states of the triplet ground state |g> and the excited triplet state |e>, which have different total spins due to the spin polarization, depends on the excitation light and duration, as well as the intensity of the excitation light. The higher the intensity and / or the longer the duration of the excitation light, the greater the probability of the second or third spin quantum number, i.e., m s =+1 or m s = -1, the first spin quantum number, m s = 0, the probability of occupancy of the |g> and |e> states is high. In contrast, for each resonant microwave absorption, which depends on the effective magnetic field at the NV center, a sufficiently strong magnetic field or microwave radiation will s =+1 or m s = -1, and therefore, after optical excitation, m s =+1 or m s = -1. A sufficiently strong magnetic field or resonant microwave absorption increases the probability of occupancy of excited states with total spin equal to the second or third spin quantum number, which have shorter lifetimes, and therefore the total lifetime of the excited triplet state is correspondingly shorter, resulting in a reduced phase shift between the excitation and emitted light. Thus, the total spin of a multi-electron system can be read out based on the determination of the phase shift, and the total spin and phase shift depend, for example, on the effective magnetic field and possibly the resonant microwave absorption at the NV center.

[0063] The method condition 412 includes checking whether a further microwave frequency within the predetermined frequency range should be selected. If this is the case, <y>If so, the method 400 continues to method step 432 where a further microwave frequency is selected. <n>, the measurement method 400 continues with method step 464. In this regard, in some variations, the predetermined frequency range can be subdivided into, for example, 200 subranges—possibly of equal width—and a corresponding microwave frequency within each range can be selected for each of the subranges. In a variation in which, for each microwave frequency, the excitation light is time-modulated and the emitted light is captured for a total time of 100 μs, the corresponding modification of the microwave radiation across the predetermined frequency range lasts 20 ms, thereby achieving a frequency resolution of approximately 25 Hz for phase shift changes. For neurons, the maximum rate of action potentials—e.g., for tetanus—is typically in the 120 Hz range, and yet a frequency resolution of 25 Hz is sufficient for detecting neuronal activity. For applications requiring higher frequency resolution, the predetermined frequency range can be reduced, the predetermined frequency range can be subdivided more coarsely, and / or the total time for generating the excitation light / time-dependent captured emitted light can be shortened. Furthermore, the frequency of the sinusoidal profile can be increased.

[0064] Method steps 464 and 466 include identifying at least one resonant frequency at which resonant microwave absorption occurs and additional resonant frequencies at which resonant microwave absorption occurs based on the identified phase shift change at each of the microwave frequencies. In some variations, in this case, in method step 464, the at least one resonant frequency is identified as the frequency at which the selected microwave frequency has a minimum phase shift below 2.87 GHz. Accordingly, in some variations, in this case, in method step 466, the additional resonant frequency is identified as the frequency at which the selected microwave frequency has a minimum phase shift above 2.87 GHz.

[0065] Method step 470 includes determining at least one magnetic field strength with respect to an (external) magnetic field or spatial direction, such as axis 148, acting at the NV center based on the frequency difference (and thus the phase shift) between at least one resonant frequency and a further resonant frequency.

[0066] In some alternative variations, the magnetic field or its strength and possibly at least one resonant frequency and further resonant frequencies are identified by numerical fitting of a model describing the resonant microwave frequency and phase shift as a function of the (external) magnetic field acting at the NV center and the frequency of the incident microwave radiation, in which case method steps 464, 466, and 470 can be combined into a single method step 470.

[0067] Furthermore, in some variants, the magnetic field or its strength is further determined based on calibration data. In this regard, in some variants, the measurement method 400 can be performed by a variant of the measurement device 200 further comprising a microwave antenna array 130 for scanning the NV centers with microwave radiation, where in a further method step one or more (pre-) magnetizations are generated for calibration purposes by the coil array 280, and the method 400 is performed in each case, thus determining the calibration data.

[0068] FIG. 5 shows a system 300 for detecting neuronal activity using the measurement head 100, namely the system 300 and the measurement head 100, each according to an embodiment of the present invention.

[0069] In one exemplary embodiment, system 300 includes control device 210, mixer device 212, bandpass filter 214, laser diode 340 as a source of excitation light, photodiode 250 as a sensor device for emitted light, radiation splitter device 254, light guide 390—in some variations—and measurement head 100—in some variations. Alternatively, in some variations, system 300 may not include measurement head 100 and / or light guide 390, in which case measurement head 100 may be coupled to system 300—e.g., via a light guide.

[0070] The radiation splitter 254 is configured to split the beam paths for the excitation light 46 and the emission light 56 ​​such that the excitation light 46 generated by the laser diode 340 is coupled into the light guide 390 and conversely, the emission light 56 ​​from the light guide 390 - i.e., for example, light having a wavelength in the range around 637 nm - is guided to the photodiode 250, while light from the light guide 390 for at least a spectral range corresponding to the spectral range of the excitation light 46 - i.e., for example, in the range around 515 nm - is not guided to the photodiode 250. In some variations, the radiation splitter device 254 is implemented as a dichroic mirror.

[0071] In one exemplary embodiment, the measurement head 100 includes a housing 190 and a nanodiamond or diamond, e.g., a NV center 140, or a plurality of NV centers, e.g., (each) [NV] - The measurement head 100 includes a macroscopic diamond having a center, a microwave antenna array 130, and an optical coupling element 194. In some variations, the measurement head 100 includes a plurality of nanodiamonds, each having at least one NV center. In some further variations, the measurement head 100 includes a macroscopic diamond having a plurality of NV centers, such as a diamond platelet. The (nano)diamond 104 and the microwave antenna array 130 are disposed within a housing 190, the optical coupling element 194 is disposed in an opening in the housing 190, and the housing, which interacts with the coupling element 194, is sealed to prevent liquids, biological cells, or other materials, such as biological tissue, from passing into and / or out of the housing 190. As a result, first, disturbances due to substances penetrating the measurement head 100 during operation of the measurement head 100 can be avoided, and second, the risk of infection from the measurement head 100 can be reduced—for example, when used to detect neuronal activity.

[0072] The optical coupling element 194 is mechanically connectable to the light guide 390 and is configured to illuminate the NV centers 340 with excitation light 46 generated by the laser diodes 340 and guided through the light guide 390, and to guide emitted light 56 ​​emitted by the NV centers into the light guide 390. In some variations, the light guide 390 has conductors for microwave signals, and the coupling element 194 is further configured to electrically connect the conductors to the microwave antenna array 130 such that the microwave signal can be supplied to the microwave antenna array 130 via the conductors. In this case, the microwave antenna array 130 is configured to emit microwave radiation when supplied with the microwave signal, thereby illuminating the NV centers 140. Additionally, the control device 210 is configured to generate the microwave signal. One advantage of the light guide 390 and / or the optical coupling element 194 may be that the excitation light 46 can be generated outside the measurement head 100 and the emitted light 56 ​​can be captured outside the measurement head 100, thereby simplifying its structure and reducing its size. One advantage of the optical coupling element 194 and the light guide 390 being simultaneously configured for the excitation light and the emitted light may be that only one light guide is required, allowing for greater flexibility (compared to two separate light guides for the excitation light and the emitted light), thereby simplifying handling, for example, during neurosurgery. In some variations, the measurement head includes the laser diode 340 and the photodiode 250, as well as an electrical coupling element instead of an optical coupling element. In this case, the measurement head is connected to (the rest of) the system 300 by an electrical cable instead of a light guide. One advantage of an electrical cable compared to a light guide may be that electrical cables are typically more flexible and / or less susceptible to impacts or bending, thereby facilitating handling, for example, during neurosurgery.

[0073] In some variations, the measurement head 100 is 10 mm 3 Less than or 5 mm 3 Less than or 2 mm 3 has a volume of less than

[0074] In some variations, the measurement head 100 is designed to be fixed to a scalpel. Alternatively, in some variations, the measurement head comprises a scalpel, in which case, in some variations, the NV center can be integrated into the scalpel blade.

[0075] In some variations, the measurement head 100 is designed to be fixed to a cannula. Alternatively, in some variations, the measurement head comprises a cannula, in which case, in some variations, the NV center can be integrated into the opening of the cannula.

[0076] In some variations, the housing 190 is internally reflectively coated so that the emitted light 56 ​​emitted by the NV center 140 passes substantially completely through the optical coupling element 194, or at least more than 50% to the optical coupling element 194, through it to the light guide 390, and then guided to the photodiode 250.

[0077] The control device 210 is configured to cause the laser diode 340 to illuminate the NV center 140 with time-period modulated excitation light, determine a phase shift between the modulation of the emitted light 56 ​​and the excitation light 46 based on the emitted light captured by the photodiode 250, and based thereon determine a measurement of the magnetic field at the NV center, thereby detecting neuronal activity of the neuron based on the magnetic field when the NV center 140 is placed in an environment of the neuron. In this case, the control device 210 is configured to correspondingly supply time-period modulated electrical energy, such as a current having a time period modulation, to the laser diode 340. The control device 210 is further configured to mix, by the mixer device 212, the sensor signal characterizing the emitted light 56 ​​determined by the photodiode 250 with a mixing frequency, which can be chosen to be at least approximately equal to or at least 1 / 10 of the modulation frequency of the excitation light, depending on whether homodyne or heterodyne operation is performed, thereby generating a frequency superposition of the sensor signal with the mixing frequency. Additionally, the control device 210 is configured to filter this superposition so produced by a bandpass filter 214 and digitize it, possibly using an analog-to-digital converter. The signal-to-noise ratio can advantageously be increased by the mixer device 212 and the bandpass filter. By varying the microwave frequency, microwave radiation can increase sensitivity due to the resonant microwave absorption that occurs - even in weak magnetic fields, perhaps less than 10 mT - and it is possible to obtain sensitivities of perhaps 1 pT / (Hz^1 / 2).

[0078] 4 as controlled by control device 210. Conversely, variations of measurement method 400 are performed by a variation of system 300, where, for example, excitation light 46 is generated by laser diode 340, emitted light 56 ​​is captured by photodiode 250, and / or microwave radiation is irradiated onto NV center 140 by microwave antenna array 130.

[0079] For some exemplary embodiments, one or more [NV] - Although described with respect to the NV centers, those skilled in the art can adapt these to further NV centers as well. In this regard, for example, the excitation light may be a so-called "hexagonal lattice site silicon vacancy (V Si In some variants with "" as excitation light, light having a wavelength of at most 861 nm, i.e. for example excitation light having a wavelength of 730 nm, is generated by a laser diode, as light from the spatial region or respectively selected spatial portion, i.e. in particular emitted light, at least with a wavelength lying in the range of 875 nm to 890 nm, is captured, and as microwave radiation, microwave radiation having a frequency in the range of 4.5 MHz is generated.

[0080] The following embodiments also arise from and / or are implemented as examples using the above.

[0081] In some embodiments, the NV center has a multi-electron system with a total spin, where the quantum state of the NV center includes multiple quantum states of the multi-electron system. The total spin of the multi-electron system in at least one excited state has a first spin quantum number, and the total spin of a second excited state of the multi-electron system has a second spin quantum number. The second excited state decays according to its lifetime upon radiation, where its lifetime is different from the lifetime of at least one excited state. In this case, the ratio of the occupation probability of the quantum state with the first spin quantum number to the occupation probability of the quantum state with the second spin quantum number depends on the measurement variable. This advantageous method converts the measurement variable into the total spin, and the total spin can be read out due to the different lifetimes caused by the phase shift.

[0082] In some embodiments, where the NV center comprises a multi-electron system with total spin, the excitation light increases the probability of occupancy of a quantum state having a first spin quantum number compared to the probability of occupancy of a quantum state having a second spin quantum number.

[0083] In some embodiments, where the NV center comprises a many-electron system with total spin, the measurement method further includes irradiating the NV center with microwaves, the frequency of which is varied over a predetermined frequency range, such that at least one resonant frequency within the predetermined frequency range, resonant microwave absorption occurs in the NV center, the resonant microwave absorption increasing the probability of occupancy of a quantum state having a second spin quantum number compared to the probability of occupancy of a quantum state having a first spin quantum number. Additionally, the measurement method includes identifying the at least one resonant frequency based on at least one change in phase shift during variation of the microwave radiation over the predetermined frequency range, and the measurement value is identified based on the at least one resonant frequency.

[0084] In some embodiments in which the NV center is irradiated with microwave radiation and resonant microwave absorption occurs, the measured variable is a magnetic field. In this case, resonant microwave absorption occurs at the NV center at an additional resonant frequency within the predetermined frequency range. Additionally, the measurement method further includes identifying the additional resonant frequency based on additional changes in the phase shift during variation of the microwave radiation across the predetermined frequency range, wherein the measurement is determined as a strength of the magnetic field based at least on the frequency shift between the at least one resonant frequency and the additional resonant frequency.

[0085] One advantage of determining a magnetic field or its strength based on the occurrence of resonant microwave absorption may be that, among other things, resonant microwave absorption allows for targeted manipulation of all spins, and the microwave frequency may be varied with high precision, resulting in higher resolution and / or sensitivity in determining measurements of the magnetic field.

[0086] In some embodiments where the NV center is irradiated with microwave radiation and resonant microwave absorption occurs, the measured variable is an electric field or material stress. Additionally, the measured value is determined as an electric field strength or material stress value based on at least a shift in at least one resonant frequency from a fundamental resonant frequency where resonant microwave absorption occurs without the electric field or material stress. In this advantageous method, additional measured variables (besides the magnetic field) can also be determined, and accuracy can be increased by resonant microwave absorption.

[0087] The NV centers are irradiated with microwave radiation, and in some embodiments where resonant microwave absorption occurs, the NV centers are continuously irradiated with microwave radiation, where the modification of the microwave radiation is slower in time than the modulation of the excitation light. This advantageous method avoids disturbances as a result of pulsed microwave radiation and makes it possible to identify the phase shift of each microwave frequency of the microwave radiation in a metastable state, thereby allowing for simple measurement sequences and / or reliable measurements.

[0088] In some embodiments, the measurement variable is a magnetic field or a local density of states in the environment of the NV center. In this case, the lifetime of at least one excited state depends on the magnetic field or the local density of states. In this advantageous manner, the measurement method can be performed without disturbances that may be caused by microwave radiation, and the corresponding measurement device can be easily implemented.

[0089] In some embodiments, the time-periodic modulation of the excitation light comprises a time-periodic modulation of the intensity of the excitation light. Further, the measurement method comprises time-dependent capture of the intensity of the emitted light of the NV center. In this case, the phase shift is determined based on the time-periodic modulation of the intensity of the excitation light and the time-dependent captured intensity of the emitted light.

[0090] In some embodiments, the time-period modulation of the excitation light includes time-period modulation of the intensity of the excitation light, and the intensity of the excitation light is time-period modulated by an acousto-optic modulator or an electro-optic modulator. In this advantageous manner, the source of the excitation light can be operated continuously, resulting in higher stability of the intensity and intensity amplitude of the excitation light emitted to the NV center.

[0091] In some embodiments, the time-period modulation of the excitation light comprises a time-period modulation of the intensity of the excitation light, the excitation light being generated by a laser device and the intensity of the excitation light being time-period modulated directly by supplying energy to the laser device. This advantageous method may enable an efficient construction of a corresponding measurement device and / or allow high modulation frequencies and / or intensity amplitudes to be obtained in the measurement method.

[0092] In some embodiments, the time-periodic modulation of the excitation light comprises a time-periodic modulation of the intensity of the excitation light, where the time-periodic modulation of the intensity of the excitation light corresponds to a sinusoidal profile. Superposition of multiple sinusoidal profiles of different frequencies is also possible, which can, for example, contribute to improving the signal.

[0093] In some embodiments, the time period modulation has frequency components in the range of 5 kHz to 700 MHz.

[0094] In some embodiments, the (measurement) apparatus further comprises a bandpass filter and is configured to bandpass filter a sensor signal determined by the sensor device, which characterizes the emitted light.

[0095] In some embodiments, the (measurement) apparatus further comprises a lock-in amplifier, configured to determine the phase shift by the lock-in amplifier based on a sensor signal determined by the sensor device and characterizing the emitted light.

[0096] Although exemplary embodiments, applicability, and examples have been described in detail, particularly with reference to the figures, it should be pointed out that numerous modifications are possible. Furthermore, it should be pointed out that the exemplary embodiments and applications are merely examples that are in no way intended to limit the scope of protection, application, and setup. Rather, the foregoing description provides guidance to those skilled in the art for implementing and / or applying at least one exemplary embodiment, and various modifications of the function and / or arrangement of the described components, in particular substitutions or additional features and / or modifications, are possible as those skilled in the art desire, without departing from the spirit—and legal equivalents thereof—and / or the scope of protection defined in the respective appended claims.< / n> < / y> < / n> < / y>

Claims

1. 1. A measurement method (400) for measuring a measurement variable based on an NV center (140) having a plurality of quantum states and also optically excitable by excitation light in response to the occupation of one of said quantum states, thereby entering at least one excited state of said quantum states, said at least one excited state decaying upon emission of emitted light (56) by said NV center, said measurement method (400) comprising: - illuminating (440) the NV centre with the excitation light (46), the excitation light having a time-period modulation, the respective occupation probabilities and / or the respective lifetimes of the quantum states depending on the measurement variable and on the excitation light; - determining (460) a phase shift between the emitted light of the NV center and the modulation of the excitation light; - determining (470) a measurement value of said measurement variable based on said phase shift; Including, The NV center (140) has a total spin (m ｓ ), and the quantum state of the NV center (140) comprises a plurality of quantum states of the multi-electron system; the total spin of the multi-electron system in the at least one excited state has a first spin quantum number, and the total spin of the multi-electron system in a second excited state has a second spin quantum number; the second excited state decays upon emission of the radiation (56) according to a lifetime different from the lifetime of the at least one excited state; A method wherein the ratio between the occupancy probability of a quantum state having the first spin quantum number and the occupancy probability of a quantum state having the second spin quantum number depends on the measurement variable.

2. The measurement method (400) of claim 1, wherein the diamond (104) has a nitrogen-vacancy center (140) as the NV center (140).

3. 3. The measurement method (400) of claim 1 or 2, wherein the excitation light (46) increases the occupation probability of a quantum state having the first spin quantum number compared to the occupation probability of a quantum state having the second spin quantum number.

4. The measurement method includes: - irradiating (430) the NV centres (140) with microwave radiation (48), the frequency of which is varied (432) over a predetermined frequency range, so that at at least one resonant frequency within the predetermined frequency range, resonant microwave absorption occurs in the NV centres, the resonant microwave absorption increasing the probability of occupation of a quantum state having the second spin quantum number compared to the probability of occupation of a quantum state having the first spin quantum number; - identifying (464) the at least one resonant frequency based on at least one change in the phase shift during the variation of the microwave radiation over the predetermined frequency range, wherein the measurement is determined based on the at least one resonant frequency; The measurement method (400) of any one of claims 1 to 3, further comprising:

5. the measured variable is a magnetic field (80); at further resonant frequencies within the predetermined frequency range, resonant microwave absorption occurs in the NV centers (140); The measurement method includes: identifying (466) additional resonant frequencies based on additional changes in the phase shift during the variation of the microwave radiation over the predetermined frequency range, the measurements being identified as a strength of the magnetic field (80) based on at least a frequency difference between the at least one resonant frequency and the additional resonant frequency; The measurement method (400) of claim 4, further comprising:

6. the measured variable is an electric field or a material stress; 5. The measurement method (400) of claim 4, wherein the measurement is determined as the strength of the electric field or the material stress value based on at least a shift of the at least one resonant frequency from a fundamental resonant frequency at which the resonant microwave absorption occurs in the absence of an electric field or material stress.

7. 7. The measurement method (400) of claim 4, wherein the NV center (140) is continuously irradiated with the microwave radiation (48), and the modification of the microwave radiation is slower in time than the modulation of the excitation light.

8. the measured variable is the magnetic field or the local density of states in the environment of the NV center (140); The measurement method (400) of any one of claims 1 to 3, wherein the lifetime of the at least one excited state depends on the magnetic field or the local density of states.

9. the time-period modulation of the excitation light includes a time-period modulation of the intensity of the excitation light (442); The measurement method includes: - time-dependent capture (450) of the intensity of the emitted light (56) of the NV center (140), The measurement method (400) of any one of claims 1 to 8, wherein the phase shift is determined based on the time-periodic modulation of the intensity of the excitation light (46) and the time-dependent intensity of the captured emitted light (56).

10. 10. The measurement method (400) of claim 9, wherein the intensity of the excitation light is time-period modulated by an acousto-optic or electro-optic modulator (246).

11. 10. The measurement method (400) of claim 9, wherein the excitation light (46) is generated by a laser device (340), and the intensity of the excitation light is time-period modulated directly by supplying energy to the laser device.

12. The measurement method (400) according to any one of claims 9 to 11, wherein the time-periodic modulation of the intensity of the excitation light corresponds to a sinusoidal profile.

13. The measurement method (400) according to any one of the preceding claims, wherein the time period modulation has frequency components in the range of 5 kHz to 700 MHz.

14. 1. A measurement method (400) for measuring a measurement variable based on an NV center (140) having a plurality of quantum states and also optically excitable by excitation light in response to the occupation of one of said quantum states, thereby entering at least one excited state of said quantum states, said at least one excited state decaying upon emission of emitted light (56) by said NV center, said measurement method (400) comprising: - illuminating (440) the NV centre with the excitation light (46), the excitation light having a time-period modulation, the respective occupation probabilities and / or the respective lifetimes of the quantum states depending on the measurement variable and on the excitation light; - determining (460) a phase shift between the emitted light of the NV center and the modulation of the excitation light; - determining (470) a measurement value of said measurement variable based on said phase shift; Including, the measured variable is the magnetic field or the local density of states in the environment of the NV center (140); A method, wherein the lifetime of the at least one excited state depends on the magnetic field or the local density of states.

15. A device (200) for measuring a measurement variable, comprising: a spatial region (204) in which one or more NV centers (140) are located; a light source (240) that illuminates the spatial region (204) with excitation light (46) having a time period modulation, whereby one or more of the NV centers (140) can be optically excited when the one or more NV centers (140) are located within the spatial region; a sensor device (250) configured to capture radiation (56) emitted by one or more of the NV centers (140); a control device (210) configured to cause the light source (240) to illuminate at least one of the NV centers (140) with the time-period modulated excitation light (46), and to determine a phase shift between the emitted light (56) and the modulation of the excitation light (46) based on the emitted light (56) captured by the sensor device (250), and to determine a measured value of the measurement variable for the at least one NV center (140) based thereon; Equipped with The NV center (140) has a total spin (m ｓ ), and the quantum state of the NV center (140) includes a plurality of quantum states of the multi-electron system; the total spin in a first excited state of the multi-electron system has a first spin quantum number, and the total spin in a second excited state of the multi-electron system has a second spin quantum number; the first and second excited states each decay according to a lifetime upon emission of the radiation (56), the lifetime of the second excited state being different from the lifetime of the first excited state; An apparatus (200) wherein the ratio between the occupation probability of a quantum state having the first spin quantum number and the occupation probability of a quantum state having the second spin quantum number depends on the measurement variable.

16. 16. The apparatus (200) of claim 15, further comprising a lock-in amplifier (216) and a band-pass filter, the apparatus being configured to filter a sensor signal determined by the sensor device (250) that characterizes the emitted light (56) with the band-pass filter, and to determine the phase shift with the lock-in amplifier (216).

17. A device (200) for measuring a measurement variable, comprising: a spatial region (204) in which one or more NV centers (140) are located; a light source (240) that illuminates the spatial region (204) with excitation light (46) having a time period modulation, whereby one or more of the NV centers (140) can be optically excited when the one or more NV centers (140) are located within the spatial region; a sensor device (250) configured to capture radiation (56) emitted by one or more of the NV centers (140); a control device (210) configured to cause the light source (240) to illuminate at least one of the NV centers (140) with the time-period modulated excitation light (46), and to determine a phase shift between the emitted light (56) and the modulation of the excitation light (46) based on the emitted light (56) captured by the sensor device (250), and to determine a measured value of the measurement variable for the at least one NV center (140) based thereon; Equipped with the measured variable is the magnetic field or the local density of states in the environment of the NV center (140); the NV center (140) has a plurality of quantum states and is optically excitable by the excitation light (46) in response to occupancy of one of the quantum states; A device (200) wherein the lifetime of the excited state of the NV center (140) depends on the magnetic field or the local density of states.

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