Ethylene-based resin composition

Abstract

To provide an ethylenic resin composition capable of obtaining a container hygienic and excellent in confirmation of content, which is free from occurence of deformation such as blocking or large wrinkles, excellent in heat resistance, and does not damage transparency, even when sterilized at 116°C or more.SOLUTION: An ethylenic resin composition that simultaneously satisfies the following formulas (1) to (3). Ht≤0.0133×e0.0350×t(1). Ht≥0.0025×e0.0450×t(2). 110≤t≤130(3) (In formulas (1) to (3), t is the temperature (°C) and Ht is an amount of melted component of the resin composition at a temperature t calculated from a formula Ht=ht / ΔHm by measuring an endothermic curve of the resin composition using the DSC endothermic peak measurement method, and determining the total amount of heat of fusion ΔHm and the total amount ht of the amount of heat of fusion from a fusion start temperature t0°C to t°C. However, if the calculated value on the right side of formula (1) exceeds 1, it is considered to be 1).SELECTED DRAWING: Figure 2

Description

[Technical Field]

[0001] The present invention relates to an etchant used for manufacturing containers for medical or food use that are excellent in transparency and heat resistance. The present invention also relates to a container using the ethylene-based resin composition. do. [Background technology]

[0002] In recent years, flexible plastic containers have become popular for storing medicinal fluids such as infusions. This type of liquid container has the advantage of being easy to handle and easy to dispose of. This type of drug solution container comes into direct contact with the drug solution. It is made of polyolefins such as polyethylene and polypropylene, whose safety has been established. These have been widely used.

[0003] Patent Document 1 describes a material that is excellent in formability, hygienic and flexible, and can withstand sterilization at 115°C or higher. It is made of polyethylene and is resistant to deformation and wrinkles, and does not lose its transparency even after processing. However, in the examples, the deformation start temperature is described, but the haze The evaluation was for sterilization at 115°C for 30 minutes, and not for sterilization at 116°C or higher. The haze of the product has not been evaluated. The transmittance at a wavelength of 450 nm was also evaluated using the ultraviolet-visible absorbance measurement method described in Experimental Method 1. Since it has not been evaluated, sterilization above 116°C is possible, and the maximum temperature at which sterilization is possible It is assumed that the condition of transmittance of 55% or more is not met.

[0004] Patent Document 2, like Patent Document 1, also reports on haze and transmittance during sterilization at 116°C or higher. No evaluation has been conducted, and it is possible to sterilize at 116°C or higher, and at the highest temperature possible for sterilization. It is assumed that the transmittance of the film does not meet the condition of 55% or more.

[0005] Patent Document 3 describes a polyethylene bag that can withstand sterilization at 118 to 121°C. However, this is characterized by a multi-layer structure and has not been implemented in a single-layer structure bag. [Prior art documents] [Patent documents]

[0006] [Patent Document 1] Japanese Patent Application Publication No. 8-244791 [Patent Document 2] Japanese Patent Application Publication No. 10-194350 [Patent Document 3] International Publication No. 2010 / 098322 Brochure Summary of the Invention [Problem to be solved by the invention]

[0007] In view of the above background art, the problem to be solved by the present invention is to provide a method for manufacturing a semiconductor device that can be used under high temperature conditions of 116°C or higher. Even when sterilized under low temperature, there is no deformation, blocking, or large wrinkles, and the transparency is excellent. Ethylene-based resin that can be used to obtain containers that are not damaged, are hygienic, and allow the contents to be easily checked The present invention provides a composition. [Means for solving the problem]

[0008] As a result of extensive research to solve the above problems, the present inventors have discovered an ethylene copolymer that satisfies specific physical properties. The resin composition is suitable for producing containers that are resistant to high-temperature sterilization and have excellent transparency. This finding led to the completion of the present invention.

[0009] That is, the present invention relates to the following [1] to [8]. [1] An ethylene-based resin composition that simultaneously satisfies the following formulas (1) to (3): H t ≦0.0133×e 0.0350×t Formula (1) H t ≧0.0025×e 0.0450×t Formula (2) (However, if the calculated value on the right side of formula (1) exceeds 1, it is considered to be 1.) 110≦t≦130 Formula (3) (In formulas (1) to (3), t indicates temperature (°C), H t is determined by measuring the endothermic peak of the resin composition using a differential scanning calorimeter (DSC). Measure the heat curve and calculate the total heat of fusion ΔH m and the total heat of fusion from the melting start temperature t0℃ to t℃ amount h t and calculate the following equation (4) H t =h t / ΔH m Formula (4) The melting point of the resin composition at temperature t is calculated by the following formula: [2] The ethylene-based resin composition according to [1], which satisfies the following requirements (a) to (c): (a) Density measured in accordance with JIS K7112 is 900 kg / m 3 Over 980kg / m 3 below (b) Melt-free measured at 190°C and a load of 2.16 kg in accordance with JIS K7210 Low rate (MFR) is 0.01g / 10min or more and 50g / 10min or less (c) The maximum peak temperature (Tm) of the endothermic curve in a differential scanning calorimeter (DSC) is 116 ℃ or higher [3] A container made of the ethylene-based resin composition according to [1] or [2]. [4] After high-temperature sterilization at 116°C for 26 minutes, the product passed the transparency test according to the 16th revision of the Japanese Pharmacopoeia. The transmittance at a wavelength of 450 nm according to the ultraviolet-visible absorbance measurement method described in Experimental Method 1 is 55% or more. [3] A container according to [3] that satisfies the above. [5] The container according to [3] or [4], wherein the average thickness of the body is 0.01 to 1.0 mm. vessel. [6] The container according to any one of [3] to [5], which has a single layer structure. [7] The container according to any one of [3] to [6], which is for medical or food use. [8] The container according to any one of [3] to [7], which is an infusion container. [Effects of the Invention]

[0010] The ethylene resin composition of the present invention can be sterilized under high temperature conditions of 116°C or higher. However, blocking and deformation such as large wrinkles may occur in containers obtained from the resin composition. Furthermore, after sterilization, the ultraviolet-visible light described in the transparency test method 1 of the 16th revision of the Japanese Pharmacopoeia The transmittance at a wavelength of 450 nm measured by absorbance measurement is 55% or more, and it has excellent high-temperature sterilization resistance. Since it is possible to obtain both transparency and transparency, it is suitable for use as a container for various purposes. [Brief explanation of the drawings]

[0011] [Figure 1] 1A and 1B are schematic diagrams illustrating an infusion bottle and an infusion bag as examples of containers according to the present invention, where (a1) is a front view of the infusion bottle, (a2) is a cross-sectional view of the bottle body, (b1) is a front view of the infusion bag, and (b2) is a cross-sectional view of the bag body. [Figure 2] 1 is a graph showing the relationship between each temperature t and the amount of melting component Ht of ethylene-based resin compositions 1 to 5. [Figure 3] 1 is a graph showing the relationship between each temperature t and the amount of melting component Ht of ethylene-based resin compositions 6 to 10. [Figure 4] 1 is a graph showing the relationship between each temperature t and the amount of melting component Ht of ethylene-based resin compositions 11 to 15. [Figure 5] 1 is a graph showing the relationship between each temperature t and the amount of melting component Ht of ethylene-based resin compositions 16 to 19. [Figure 6] 1 is a graph showing the relationship between each temperature t and the amount of melting component Ht of ethylene-based resin compositions 20 to 22. [Figure 7] 1 is a graph showing the relationship between each temperature t and the amount of melting component Ht of ethylene-based resin compositions C1 to C6. [Figure 8] 1 is a graph showing the relationship between each temperature t and the amount of melting component Ht of ethylene-based resin compositions C7 to C12. [Figure 9] 1 is a graph showing the relationship between each temperature t and the amount of melting component Ht of ethylene-based resin compositions C13 to C16. [Figure 10] 1 is a graph showing the relationship between the temperature t and the amount of melting component Ht of ethylene-based resin compositions C17 and C18. DETAILED DESCRIPTION OF THE INVENTION

[0012] The ethylene-based resin composition according to the present invention and various uses of the resin composition will be described in detail below. Explain.

[0013] The ethylene-based resin composition of the present invention satisfies the following formulas (1) to (3) simultaneously: It is characterized by: H t ≦0.0133×e 0.0350×t Formula (1) H t ≧0.0025×e 0.0450×t Formula (2) 110≦t≦130 Formula (3) However, if the calculated value of the right side of formula (1) exceeds 1, it is considered to be 1. In calculations, the right-hand side of equation (1) may exceed 1. t By definition, it exceeds 1 Therefore, if the right side of equation (1) exceeds 1, it is considered to be 1. There's no problem. In the above formulas (1) to (3), t represents temperature (°C), and H t is the resin composition at temperature t is the amount of molten material. Here, H t The resin composition is determined by the DSC endothermic peak measurement method. The endothermic curve of the substance is measured, and the total heat of fusion ΔH m and the heat of fusion from the melting start temperature t0℃ to t℃ Total amount h t is calculated using the following equation (4). H t =h t / ΔH m Formula (4)

[0014] Formula (1) preferably satisfies the following formula (1'), more preferably the following formula (1'') ), and more preferably satisfies the following formula (1'''). H t ≦0.0104×e 0.0370×t Formula (1') H t ≦0.0094×e 0.0379×t expression(1'') H t ≦0.0091×e 0.0381×t expression(1''') However, in all of the formulas (1'), (1'') and (1''), the calculation of the right-hand side If the value is greater than 1, it is considered to be 1.

[0015] Furthermore, the formula (2) preferably satisfies the following formula (2'), and more preferably the following formula ( 2″), and more preferably satisfies the following formula (2′″): H t ≧0.0023×e 0.0457×t Formula (2') H t ≧0.0020×e 0.0470×t expression(2'') H t ≧0.0012×e 0.0515×t expression(2''')

[0016] When the ethylene-based resin composition of the present invention satisfies the above formula (1), the resin composition The molded articles such as containers obtained from this product will not deform or become distorted even when sterilized under high-temperature conditions of 116°C or higher. Defects such as wrinkles and blocking are less likely to occur, and sterilization is improved. In addition, when the ethylene-based resin composition according to the present invention satisfies the above formula (2), the resin Molded articles such as containers obtained from the composition shall meet the transparency test method 1 of the 16th revision of the Japanese Pharmacopoeia. The transmittance at a wavelength of 450 nm measured by the ultraviolet-visible absorbance measurement method is 55% or more, and the Sexuality improves. Formula (1) and its sub-formulas, and formula (2) and its sub-formulas are used in the examples described later. The area through which the t curve passes is specified, and the upper and lower limit curves are quantified using the least squares method. do.

[0017] Furthermore, the ethylene-based resin composition of the present invention satisfies the following requirements (a) to (c): It is preferable that:

[0018] (a) Density measured in accordance with JIS K7112 is 900 kg / m 3 Over 980kg / m 3 The following is the result. The lower limit of the density is preferably 905 kg / m 3 , more preferably 910 kg / m 3 ,Sara Preferably 915 kg / m 3 The upper limit of the density is preferably 975 kg / m 3 ,Yo More preferably 970 kg / m 3 , and more preferably 965 kg / m 3 is. The density of the ethylene resin composition is 900 kg / m 3 If it is more than this, it is preferable in terms of heat resistance. , 980 kg / m 3 It is preferable in terms of transparency if it is not more than this.

[0019] (b) Melt-free measured at 190°C and a load of 2.16 kg in accordance with JIS K7210 The MFR is 0.01g / 10min or more and 50g / 10min or less. The lower limit of the MFR is preferably 0.05 g / 10 min, more preferably 0.1 g / 10 min. The upper limit of the MFR is preferably 20 g / 10 min. , more preferably 15 g / 10 min, and even more preferably 10 g / 10 min. If the MFR of the ethylene-based resin composition is 0.01 g / 10 min or more, it is preferable in terms of appearance. A melt flow rate of 50 g / 10 min or less is preferable in terms of stability during molding.

[0020] (c) The maximum peak temperature (Tm) of the endothermic curve in a differential scanning calorimeter (DSC) is 116 °C or higher. The maximum peak temperature (Tm) is preferably 117°C or higher, more preferably 118°C or higher; The upper limit of the maximum peak temperature (Tm) is more preferably 119°C or higher. It is determined by the melting point of the ethylene polymer, so there is no special regulation. It is below 5°C. When the maximum peak temperature (Tm) of the ethylene resin composition is 116°C or higher, the composition has good heat resistance. is preferable.

[0021] Examples of the ethylene polymer constituting the ethylene resin composition of the present invention include high-pressure High-performance low-density polyethylene (HP-LDPE), linear low-density polyethylene (LLDPE), High density polyethylene (HDPE), ethylene-α-olefin copolymer, ethylene-acid copolymer Polymers and the like are examples.

[0022] High-pressure low-density polyethylene (HP-LDPE) has a density of 910 to 940 kg / m 3 The melt flow rate (MFR) measured at 190°C under a load of 2.16 kg is 0.05 to A 50g / 10min is preferably used.

[0023] Linear low-density polyethylene (LLDPE) has an ethylene content of 80 to 99 wt%. It contains 1-20 wt% of α-olefin with 3-10 carbon atoms as a comonomer, and has a density of 89 5 to 948 kg / m 3 , melt flow rate (M The FR is preferably 0.01 to 50 g / 10 min. High density polyethylene (HDPE) has a density of 948-980 kg / m 3 , 190℃ The melt flow rate (MFR) measured under a 2.16 kg load is 0.01 to 50 g / 10 Preferably, the above-mentioned one is used. Ethylene-α-olefin copolymers have an ethylene content of 60-85 wt% and It contains 15-40 wt% of α-olefin with 3-10 carbon atoms as a monomer, and has a density of 860- 895kg / m 3 Melt flow rate (MFR) measured at 190°C under a load of 2.16 kg ) is preferably 0.01 to 50 g / 10 min. As ethylene-acid copolymer, ethylene content is 65-99 wt%, copolymerized with ethylene The content of the acid copolymer (specifically, vinyl acetate, acrylic acid, methacrylic acid, etc.) is 1 The melt flow rate (MF) measured at 190°C under a load of 2.16 kg was R) of 0.01 to 50 g / 10 min is preferably used.

[0024] The ethylene-based resin composition of the present invention may be any resin as long as it satisfies the above formulas (1) to (3) simultaneously. In the above, even in an embodiment in which one ethylene polymer is used alone, two or more ethylene polymers may be used. It may be a mixture of an ethylene-based polymer and an olefin other than an ethylene-based polymer. It may be a mixture with a vinyl-based resin composition or a styrene-based resin composition. When this embodiment is adopted, there is no particular limitation on the blending ratio of each polymer. As long as the formulas (1) to (3) are satisfied simultaneously, any blending ratio is acceptable. None.

[0025] In the case where two or more kinds of ethylene polymers are used in combination, the following is a preferred embodiment: Examples include: (I) Density 895kg / m 3 or more and 920 kg / m 3 Linear low-density polyethylene less than 1 to 99 parts by mass of polyethylene (LLDPE) and a density of 920 kg / m 3 or more and 948 kg / m 3 1 to 99 parts by mass of the following linear low-density polyethylene (LLDPE) (total of 100 parts by mass of both types) Combination with (II) Density 895kg / m 3 or more and 920 kg / m 3 Linear low-density polyethylene less than 1 to 90 parts by mass of polyethylene (LLDPE) and a density of 920 kg / m 3 or more and 948 kg / m 3 1 to 90 parts by mass of the following linear low-density polyethylene (LLDPE) and high-density polyethylene (HDPE) 1 to 50 parts by mass (total of 3 types: 100 parts by mass), (III) Density 895kg / m 3 or more and 920 kg / m 3 Linear low density polyester less than 1 to 90 parts by mass of polyethylene (LLDPE) and a density of 920 kg / m 3 Over 948kg / m 3 1 to 90 parts by mass of the following linear low-density polyethylene (LLDPE) and high-density polyethylene 1 to 50 parts by mass of high-density polyethylene (HDPE) and 1 to 5 parts by mass of high-pressure low-density polyethylene (HP-LDPE) Combination with 0 parts by mass (total of 4 types: 100 parts by mass).

[0026] The ethylene-based resin composition of the present invention is a mixture of two or more ethylene-based polymers. In this case, the mixing method is not particularly limited, and a general known method may be used. For example, it can be added directly to the pelletizing process after polymerization. Alternatively, dry blending may be carried out during molding.

[0027] The above-mentioned ethylene polymers can be produced by a high-pressure method, a slurry method, a solution method, etc. Polymers can be produced by the slurry method, solution method, gas phase method, etc. In this case, the olefin polymerization catalyst used may be a magnesium chloride supported titanium catalyst, Phillips catalyst, metallocene catalyst, etc. are examples of catalysts used in ethylene-based resin compositions. As long as the formulae (1) to (3) are simultaneously satisfied, there is no limitation on the method for producing the ethylene polymer to be used. stomach.

[0028] The ethylene-based resin composition of the present invention may contain any of the following components as necessary within the range that does not impair the effects of the present invention. If necessary, antioxidants, weather stabilizers, antistatic agents, lubricants, antiblocking agents, etc. may be added. Additives used in polyolefins may also be added. The method for mixing the additives is not particularly limited. For example, the additives may be mixed in the pellets after polymerization. There are two methods: adding it directly in the granulation process, or creating a high-concentration master batch in advance and adding it to the mold during molding. A live blend method may also be used.

[0029] The ethylene-based resin composition according to the present invention satisfies the above formulas (1) to (3) simultaneously. By combining these two, it has excellent heat resistance and transparency, making it suitable for use as a material for various containers. You can be there. Containers that meet the above requirements are particularly suitable for medical or food applications. In particular, it is preferably a container for infusion.

[0030] The shape of the container is selected arbitrarily depending on the use of the container, and is not particularly limited. Generally, the container may be in the shape of a bottle or a bag. As long as the desired properties can be obtained, there are no particular limitations, but blow molding, water molding, etc. are preferred. Examples include cold inflation molding, air-cooled inflation molding, and T-die casting. can be.

[0031] The container is steam sterilized at 116°C for 26 minutes, and then conforms to the 16th revision of the Japanese Pharmacopoeia. Purple described in the transparency test method 1 in "7.02 Plastic Pharmaceutical Container Test Method" It is preferable that the transmittance at a wavelength of 450 nm according to the ultraviolet-visible absorbance measurement method is 55% or more. The transmittance is more preferably 56% or more, and even more preferably 57% or more. The transmittance after steam sterilization at 118°C for 16 minutes and at 121°C for 15 minutes was If the transmittance is 55% or more, the transmittance will be 55% or more even after sterilization at 116°C for 26 minutes. is deemed to be fulfilled. Furthermore, the haze after the sterilization treatment is preferably 50% or less, and more preferably 45% or less. It is more preferable that the ratio is 40% or less, and even more preferable that the ratio is 40% or less.

[0032] The transmittance is determined by the fact that the ethylene-based resin composition used for producing the container satisfies the above formulas (1) to (3). However, if higher transmittance is required, Use of various polymers with different physical properties that constitute the ethylene-based resin composition Alternatively, methods such as changing the composition ratio can be adopted. When the transmittance satisfies the above range, the resulting container is shown to have high heat resistance and transparency. will be done.

[0033] In addition, when the container is a bottle, the thickness of the body of the container is preferably 0.01 1.00 mm, more preferably 0.10 to 0.70 mm, and even more preferably 0.15 to In addition, when the container is a bottle, the thickness of the neck is preferably in the range of 0.60 mm. Preferably, the thickness is 0.01 to 1.00 mm, more preferably 0.40 to 1.00 mm, and even more preferably is in the range of 0.50 to 0.80 mm. Similarly, if the container is a bottle, The thickness of the shoulder is preferably 0.01 to 1.00 mm, more preferably 0.10 to 0.70 mm. The thickness is preferably in the range of 0.20 to 0.50 mm. In addition, when the container is a bag, the thickness of the body of the container is preferably 0.01 to 1.00 mm, more preferably 0.10 to 0.50 mm, and even more preferably 0.15 to 0 The range is 0.30mm.

[0034] FIG. 1 shows an infusion bottle 10 as an infusion container and an infusion device as one embodiment of the container according to the present invention. 1 is a schematic diagram of the infusion bag 20. (a1) is a front view of the infusion bottle 10, and (a2) is a view of the bottle body. (b1) is a front view of the infusion bag 20; (b2) is a cross-sectional view of the bag body taken along line BB. Cross-sectional view. The infusion bottle 10 has a body 11, a shoulder 12, a neck 13, a cap 14, and is attached to an infusion stand. The clamp part 15 has a hole for hanging. The clamp part 15 holds the cap part up. The infusion bag 20 has a body portion, which is a liquid storage portion 2. 1, and a seal portion 22 is provided around the infusion bag 1, and a liquid storage portion 21 and an infusion bag 22 are provided at an opening for infusion. A cylindrical member 23 is engaged with the seal 20 to allow the inflow and outflow of a liquid medicine or the like. On the opposite side of the cylindrical member 23 of the portion 22, a hole 24 is provided for hanging it on an infusion stand. The thickness of the body as described above means the average thickness, and is measured at the body of the container. For example, the 16 regions shown in Figure 1(a1) are selected as follows: The thickness is measured at 10 random points and the average value is taken. The thickness of the central part C from the base of the neck to the shoulder R part of the container is measured. The thickness is measured at the shoulder R portion D of the container. The thickness of the body of the infusion bag 20 is For example, the thickness of 10 arbitrary points in the 25 regions shown in Figure 1(b1) is measured, and the average value is calculated. It is a combination of the following. In the infusion bottle 10, the part excluding the cap, and in the infusion bag 20, the part excluding the cylindrical member 23 It is preferable that the bottle is constituted by containing the ethylene-based resin composition according to the present invention. In this case, the clamp portion is not provided in the portion containing the ethylene-based resin composition. It is also possible to use a configuration in which a separately prepared clamp part is attached.

[0035] Furthermore, the container may have a single layer or a multi-layer structure of two or more types. It is preferable from the viewpoint of simplification of molding of the container. Containers made of the resin composition, even if they are formed as a single layer, can be sterilized at 116°C or higher. After processing, the container does not deform, block, or wrinkle, so it is The container is superior to a container made of an ethylene-based resin composition.

[0036] As a high-temperature sterilization method for a container according to the present invention, for example, in the case of a medicinal liquid such as an infusion, the following method is usually used: The container (medicine bottle or medicine bag) is sealed and sterilized by high-pressure steam or hot water. Known heat sterilization processes such as shower sterilization can be applied. The processing temperature is generally about 105 to 110°C, but in the present invention, heating is performed at 116°C or higher. Sterilization temperature can be adjusted according to the type of chemical, usage, and environment. It can also be set to 118-121°C. [Example]

[0037] The present invention will be described below with reference to examples, but the present invention is not limited to these examples. There is no. The physical properties of the ethylene resin compositions used in the examples and comparative examples were determined by the following analytical methods. Measured.

[0038] (density) According to JIS K7112:99, method D, the sample was immersed in hot water at 100°C for 60 minutes, and then The sample was allowed to cool to room temperature and then measured.

[0039] (MFR (Melt Flow Rate)) Measurement was carried out in accordance with JIS K7210:99 at 190°C under a load of 2.16 kg.

[0040] (Melting point (Tm)) The analysis was carried out using a PerkinElmer DSC-7 type device. The melting point (Tm) was determined by measuring the endothermic curve. The temperature was set to the maximum peak temperature, and approximately 5 mg of sample was packed in an aluminum pan and heated at 10°C / min to 230°C. The temperature was raised to 230°C, held at 230°C for 10 minutes, then lowered to 30°C at a rate of 10°C / min, and then It was determined from the endothermic curve when the temperature was raised at 10°C / min.

[0041] (Melting component amount (H t )) Amount of molten component H t The endothermic curve of the sample was measured using the DSC endothermic peak measurement method. Total heat of fusion of material ΔH m and the total heat of fusion from the melting start temperature t0℃ to t℃ h t Seeking Calculated using formula (4). H t =h t / ΔH m ...Equation (4)

[0042] The bottles and bags produced in the examples and comparative examples were produced by the following methods. Each was evaluated for the following items.

[0043] (Bottle manufacturing) The ethylene-based resin compositions prepared in the examples and comparative examples were blown into a mold using a blow molding machine manufactured by Romerag. Cylinder temperature 160-180℃, die temperature 160-180℃, mold temperature 15-2 0℃, blow pressure 3kg / cm 2 -G condition, the thickness of the body of the hollow molded product (bottle) is The thickness of the neck is approximately 0.65 mm, and the thickness of the shoulder is approximately 0.4 mm. The bottle has an oval body with dimensions of L68 x W40 x H75, and a neck. The part was molded to have a new circular shape with dimensions of Φ20 x H14.

[0044] (Bag manufacturing) The ethylene-based resin compositions prepared in the examples and comparative examples were used in a water-cooled inflation machine manufactured by Placo Co., Ltd. Using a molding machine, cylinder temperature 190-200℃, die temperature 200℃, extrusion amount 62kg / h, film was produced with a sizing diameter of 320 mm, and the upper and lower molds were heated to 168°C for 1.85 seconds. The four sides were sealed to produce a bag with an inner dimension of 125 x 200 mm and a seal width of 6 mm.

[0045] (Sterilization) The bottle obtained by the above method was filled with 100 mL of distilled water, and then the bottle was capped and used in a Hisaka Works Sterilize using a hot water spray sterilizer under one of the conditions shown in Table 1, then cool to room temperature. I rejected it. In addition, the bag obtained by the above method was filled with 500 mL of distilled water, and then the bag was sealed and used for storage. Sterilize the product using a hot water spray sterilizer manufactured by Sakusho under one of the conditions shown in Table 1, and then store at room temperature. It was cooled to.

[0046] [Table 1]

[0047] (Transmittance at wavelength 450 nm) After the above sterilization process, the bottles and bags are tested in accordance with the transparency test method 1 of the 16th revision of the Japanese Pharmacopoeia. The transmittance at a wavelength of 450 nm was measured by the UV-visible absorbance measurement method described below. Specifically, test pieces of a certain shape were cut out from the bottles and bags after the sterilization treatment. After 48 hours or more have passed since sterilization, the sample was subjected to a 450 nm wavelength transmittance test using a Shimadzu UV-1800. The pass rate was measured.

[0048] (average thickness) The average thickness of the body is determined so that the curvature is as small as possible from the body of the bottle or bag after the sterilization process. The bottle is shown in the hatched area 16 in Figure 1(a1), and the bag is shown in Figure 1(b1). Ten arbitrary points were cut out as test pieces from the hatched area 25), and the thickness of each test piece was Measured using a Mitutoyo Corporation Digimatic Micrometer MDC-25M (product name) The average value of the 10 measurement results was calculated. The average thickness of the neck is the center C from the base of the neck to the shoulder R of the bottle after the above sterilization process. was measured using Magna-Mike8500 (trade name) manufactured by Olympus Corporation. The average thickness of the shoulder was measured by measuring the shoulder R part D of the bottle after the sterilization treatment with an Olympus Magna -Measured using Mike8500.

[0049] (HAZE) The haze of the bottles and bags after the above sterilization process was measured by measuring the transmittance of the above wavelength of 450 nm. The same test pieces as those mentioned above were measured using a haze meter NDH5 manufactured by Nippon Denshoku Industries Co., Ltd. Measurement was carried out using 000 (trade name).

[0050] (Appearance evaluation) The appearance of the bottles after the sterilization treatment was evaluated according to the items in Table 2 below.

[0051] [Table 2]

[0052] The appearance of the bag after the sterilization treatment was evaluated for deformation. After sterilization, inspect the bag and check for any folds or large wrinkles at the seal edge. We checked to see if the bag was expanding and deforming.

[0053] The ethylene-based resin compositions used in the examples and comparative examples were prepared by mixing the following various ethylene-based polymers: It was prepared using

[0054] Linear low-density polyethylene (LLDPE) (LL-1)MFR:1.0g / 10min, density:904kg / m 3 , melting point 90℃, M w / Mn=3.0 (LL-2)MFR:3.7g / 10min, density:918kg / m 3 , melting point 114℃, Mw / Mn=2.2 (LL-3)MFR:1.4g / 10min, density:921kg / m 3 , melting point 121℃, Mw / Mn=2.9 (LL-4)MFR:2.1g / 10min, density:921kg / m 3 , melting point 115℃, Mw / Mn=2.9 (LL-5)MFR:2.2g / 10min, density:937kg / m 3 , melting point 125℃, Mw / Mn=2.7 High-density polyethylene (HDPE) (HD-1)MFR:17g / 10min, density:959kg / m 3 , melting point 131℃, M w / Mn=2.8 (HD-2)MFR:2.1g / 10min, density:940kg / m 3 , melting point 126℃, Mw / Mn=2.7 (HD-3)MFR:0.43g / 10min, density:944kg / m 3 , melting point 129℃ , Mw / Mn=6.0 High-pressure low-density polyethylene (HP-LDPE) (LD-1)MFR:0.9g / 10min, density:929kg / m 3 , melting point 114℃, Mw / Mn=5.1 (LD-2)MFR:0.32g / 10min, density:925kg / m 3 , melting point 116℃ , Mw / Mn=5.0 (LD-3)MFR:0.4g / 10min, density:927kg / m 3 , melting point 114℃, Mw / Mn=5.0

[0055] [Example 1] Ethylene obtained by blending 50 parts by mass of LL-1 and 50 parts by mass of LL-5 The polyethylene resin composition 1 was used to manufacture a bottle container and sterilize it under condition 4. The results are shown in Table 3. The melt content Ht are shown in Table 4 and Figure 2.

[0056] [Example 2] Ethylene obtained by blending 40 parts by mass of LL-1 and 60 parts by mass of LL-5 The polyethylene resin composition 2 was used to manufacture a bottle container and sterilize it under condition 4. The results are shown in Table 3. The melt content Ht are shown in Table 4 and Figure 2.

[0057] [Example 3] Ethylene obtained by blending 30 parts by mass of LL-1 and 70 parts by mass of LL-5 The polyethylene resin composition 3 was used to manufacture a bottle container and sterilize it under condition 4. The results are shown in Table 3. The melt content Ht are shown in Table 4 and Figure 2.

[0058] [Example 4] Mixing ratio: 47.5 parts by weight of LL-1, 47.5 parts by weight of LL-5, 5 parts by weight of HD-1 The ethylene-based resin composition 4 obtained by blending the above-mentioned components in a ratio of 1:1 is used to manufacture a bottle container. Sterilization was carried out under condition 4, and the container after sterilization was evaluated. The results are shown in Table 3. The amount of melting component Ht of resin composition 4 is shown in Table 4 and FIG.

[0059] [Example 5] The blend ratio is 38 parts by weight of LL-1, 57 parts by weight of LL-5, and 5 parts by weight of HD-1. The ethylene-based resin composition 5 obtained by blending was used to manufacture a bottle container and The container was sterilized and evaluated after sterilization. The results are shown in Table 3. The ethylene resin composition The melting component amount Ht of the product 5 is shown in Table 4 and FIG.

[0060] [Example 6] 45 parts by weight of LL-1, 45 parts by weight of LL-5, 5 parts by weight of HD-1, 5 parts by weight of LD-1 The ethylene resin composition 6 obtained by blending the above resins in a blending ratio of 100 parts is used to make a bottle container. The containers were manufactured and sterilized under condition 4, and the containers after sterilization were evaluated. The results are shown in Table 3. The melt content Ht of the ethylene-based resin composition 6 is shown in Table 5 and FIG.

[0061] [Example 7] 35 parts by weight of LL-1, 35 parts by weight of LL-5, 5 parts by weight of HD-1, 25 parts by weight of LD-1 The ethylene-based resin composition 7 obtained by blending the above resins in a blending ratio of parts by mass was used to produce a bottle container. The containers were manufactured and sterilized under condition 4, and the containers after sterilization were evaluated. The results are shown in Table 3. The melt content Ht of the ethylene resin composition 7 is shown in Table 5 and FIG.

[0062] [Example 8] 60 parts by weight of LL-1, 30 parts by weight of LL-5, 5 parts by weight of HD-1, 5 parts by weight of LD-1 The ethylene resin composition 8 obtained by blending the above components in a blending ratio of 100 parts is used to make a bottle container. The containers were manufactured and sterilized under condition 4, and the containers after sterilization were evaluated. The results are shown in Table 3. The melt content Ht of the ethylene-based resin composition 8 is shown in Table 5 and FIG.

[0063] [Example 9] 50 parts by weight of LL-1, 40 parts by weight of LL-5, 5 parts by weight of HD-1, 5 parts by weight of LD-1 The ethylene resin composition 9 obtained by blending the above resins in a blending ratio of 100 parts was used to make a bottle container. The containers were manufactured and sterilized under condition 4, and the containers after sterilization were evaluated. The results are shown in Table 3. The melt content Ht of the ethylene-based resin composition 9 is shown in Table 5 and FIG.

[0064] [Example 10] 40 parts by weight of LL-1, 50 parts by weight of LL-5, 5 parts by weight of HD-1, 5 parts by weight of LD-1 The ethylene resin composition 10 obtained by blending the above components in a blending ratio of 100 parts is used to produce a bottle container. The containers were manufactured and sterilized under condition 4, and the containers after sterilization were evaluated. The results are shown in Table 3. The melt content Ht of the ethylene resin composition 10 is shown in Table 5 and FIG.

[0065] [Table 3]

[0066] [Table 4]

[0067] [Table 5]

[0068] [Example 11] 35 parts by weight of LL-1, 50 parts by weight of LL-5, 5 parts by weight of HD-1, 10 parts by weight of LD-1 The ethylene resin composition 11 obtained by blending the above components in a blending ratio of parts by mass was used to make a bottle. The containers were manufactured and sterilized under conditions 4 and 5, and the containers after each sterilization were evaluated. The results are shown in Table 6. The melt content Ht of the ethylene resin composition 11 is shown in Table 7 and FIG.

[0069] [Example 12] 25 parts by weight of LL-1, 50 parts by weight of LL-5, 5 parts by weight of HD-1, 20 parts by weight of LD-1 The ethylene resin composition 12 obtained by blending the resins in a blending ratio of parts by mass was used to make a bottle. The containers were manufactured and sterilized under conditions 4 and 5, and the containers after each sterilization were evaluated. The results are shown in Table 6. The melt content Ht of the ethylene resin composition 12 is shown in Table 7 and FIG.

[0070] [Example 13] 28 parts by weight of LL-1, 57 parts by weight of LL-5, 5 parts by weight of HD-1, 10 parts by weight of LD-1 The ethylene resin composition 13 obtained by blending the above components in a blending ratio of parts by mass was used to make a bottle. The containers were manufactured and sterilized under conditions 4 and 5, and the containers after each sterilization were evaluated. The results are shown in Table 6. The melt content Ht of the ethylene resin composition 13 is shown in Table 7 and FIG.

[0071] [Example 14] 18 parts by weight of LL-1, 37 parts by weight of LL-5, 5 parts by weight of HD-1, 40 parts by weight of LD-1 The ethylene resin composition 14 obtained by blending the resins in a blending ratio of parts by mass was used to make a bottle. The containers were manufactured and sterilized under conditions 4 and 5, and the containers after each sterilization were evaluated. The results are shown in Table 6. The melt content Ht of the ethylene resin composition 14 is shown in Table 7 and FIG.

[0072] [Example 15] 12 parts by weight of LL-1, 23 parts by weight of LL-5, 5 parts by weight of HD-1, 60 parts by weight of LD-1 The ethylene resin composition 15 obtained by blending the resins in a blending ratio of parts by mass was used to make a bottle. The containers were manufactured and sterilized under conditions 4 and 5, and the containers after each sterilization were evaluated. The results are shown in Table 6. The melt content Ht of the ethylene resin composition 15 is shown in Table 7 and FIG.

[0073] [Example 16] 40 parts by weight of LL-1, 50 parts by weight of LL-5, 5 parts by weight of HD-1, 5 parts by weight of LD-3 The ethylene resin composition 16 obtained by blending the above components in a blending ratio of 100 parts is used to produce a bottle container. The containers were manufactured and sterilized under conditions 4 and 5, and the containers after each sterilization were evaluated. The results are shown in Table 6. The melt content Ht of the ethylene resin composition 16 is shown in Table 8 and FIG.

[0074] [Example 17] 35 parts by weight of LL-1, 50 parts by weight of LL-5, 5 parts by weight of HD-1, 10 parts by weight of LD-3 The ethylene resin composition 17 obtained by blending the above resins in a blending ratio of parts by mass was used to make a bottle. The containers were manufactured and sterilized under conditions 4 and 5, and the containers after each sterilization were evaluated. The results are shown in Table 6. The melt content Ht of the ethylene resin composition 17 is shown in Table 8 and FIG.

[0075] [Example 18] 25 parts by weight of LL-1, 50 parts by weight of LL-5, 5 parts by weight of HD-1, 20 parts by weight of LD-3 The ethylene resin composition 18 obtained by blending the resins in a blending ratio of parts by mass was used to make a bottle. The containers were manufactured and sterilized under conditions 4 and 5, and the containers after each sterilization were evaluated. The results are shown in Table 6. The melt content Ht of the ethylene resin composition 18 is shown in Table 8 and FIG.

[0076] [Example 19] 5 parts by weight of LL-1, 50 parts by weight of LL-5, 5 parts by weight of HD-1, 40 parts by weight of LD-3 The ethylene-based resin composition 19 obtained by blending the above components in a blending ratio of 100 parts is used to produce a bottle container. The containers were manufactured and sterilized under conditions 4 and 5, and the containers after each sterilization were evaluated. The results are shown in Table 6. The melt content Ht of the ethylene resin composition 19 is shown in Table 8 and FIG.

[0077] [Example 20] 28 parts by weight of LL-1, 57 parts by weight of LL-5, 5 parts by weight of HD-1, 10 parts by weight of LD-3 The ethylene resin composition 20 obtained by blending the above components in a blending ratio of parts by mass was used to make a bottle. The containers were manufactured and sterilized under conditions 4 and 5, and the containers after each sterilization were evaluated. The results are shown in Table 6. The melt content Ht of the ethylene resin composition 20 is shown in Table 9 and FIG.

[0078] [Example 21] 18 parts by weight of LL-1, 37 parts by weight of LL-5, 5 parts by weight of HD-1, 40 parts by weight of LD-3 The ethylene resin composition 21 obtained by blending the above components in a blending ratio of parts by mass was used to make a bottle. The containers were manufactured and sterilized under conditions 4 and 5, and the containers after each sterilization were evaluated. The results are shown in Table 6. The melt content Ht of the ethylene resin composition 21 is shown in Table 9 and FIG.

[0079] [Example 22] 12 parts by weight of LL-1, 23 parts by weight of LL-5, 5 parts by weight of HD-1, 60 parts by weight of LD-3 The ethylene resin composition 22 obtained by blending the resins in a blending ratio of parts by mass was used to make a bottle. The containers were manufactured and sterilized under conditions 4 and 5, and the containers after each sterilization were evaluated. The results are shown in Table 6. The melt content Ht of the ethylene resin composition 22 is shown in Table 9 and FIG.

[0080] [Table 6]

[0081] [Table 7]

[0082] [Table 8]

[0083] [Table 9]

[0084] [Comparative Example 1] Ethylene obtained by blending 60 parts by mass of LL-1 and 40 parts by mass of LL-5 The polyethylene resin composition C1 was used to manufacture a bottle container and sterilize it under condition 4. The results are shown in Table 10. The melting component of the ethylene resin composition C1 was The quantity Ht is shown in Table 12 and FIG.

[0085] Comparative Example 2 The blending ratio was 40 parts by weight of LL-1, 40 parts by weight of LL-5, and 20 parts by weight of HD-1. The ethylene-based resin composition C2 obtained by blending was used to manufacture a bottle container under the following conditions: The container was sterilized at 4°C, and the sterilized container was evaluated. The results are shown in Table 10. The melting component amount Ht of the fat composition C2 is shown in Table 12 and FIG.

[0086] Comparative Example 3 The blend ratio was 32 parts by weight of LL-1, 48 parts by weight of LL-5, and 20 parts by weight of HD-1. The ethylene-based resin composition C3 obtained by blending was used to manufacture a bottle container and The container was sterilized at 4°C, and the sterilized container was evaluated. The results are shown in Table 10. The melting component amount Ht of the fat composition C3 is shown in Table 12 and FIG.

[0087] Comparative Example 4 70 parts by weight of LL-1, 20 parts by weight of LL-5, 5 parts by weight of HD-1, 5 parts by weight of LD-1 The ethylene resin composition C4 obtained by blending the above components in a blending ratio of 100 parts was used to manufacture a bottle container. The containers were manufactured and sterilized under condition 4, and the containers after sterilization were evaluated. The results are shown in Table 10. The melt content Ht of the ethylene resin composition C4 is shown in Table 12 and FIG.

[0088] Comparative Example 5 30 parts by weight of LL-1, 60 parts by weight of LL-5, 5 parts by weight of HD-1, 5 parts by weight of LD-1 The ethylene resin composition C5 obtained by blending the above components in a blending ratio of 100 parts was used to manufacture a bottle container. The containers were manufactured and sterilized under condition 4, and the containers after sterilization were evaluated. The results are shown in Table 10. The melt content Ht of the ethylene resin composition C5 is shown in Table 12 and FIG.

[0089] Comparative Example 6 20 parts by mass of LL-1, 70 parts by mass of LL-5, 5 parts by mass of HD-1, 5 parts by mass of LD-1 The ethylene-based resin composition C6 obtained by blending the above resins in a blending ratio of 100 parts was used to manufacture a bottle container. The containers were manufactured and sterilized under condition 4, and the containers after sterilization were evaluated. The results are shown in Table 10. The melt content Ht of the ethylene resin composition C6 is shown in Table 12 and FIG.

[0090] Comparative Example 7 Ethylene obtained by blending 95 parts by mass of LL-2 and 5 parts by mass of HD-2 The resin composition C7 was used to manufacture a bottle container and sterilize it under condition 4. The results are shown in Table 10. The amount of melting component of the ethylene resin composition C7 was also evaluated. Ht is shown in Table 13 and FIG.

[0091] [Comparative Example 8] Ethylene obtained by blending 90 parts by mass of LL-2 and 10 parts by mass of HD-2 The polyethylene resin composition C8 was used to manufacture a bottle container and sterilize it under condition 4. The results are shown in Table 10. The melting point of the ethylene resin composition C8 was 100%. The quantity Ht is shown in Table 13 and FIG.

[0092] Comparative Example 9 Ethylene obtained by blending 95 parts by mass of LL-2 and 5 parts by mass of HD-1 The resin composition C9 was used to manufacture a bottle container and sterilize it under condition 4. The results are shown in Table 10. The amount of melt component of the ethylene-based resin composition C9 was also evaluated. Ht is shown in Table 13 and FIG.

[0093] [Comparative Example 10] Ethylene obtained by blending 70 parts by mass of LL-2 and 30 parts by mass of HD-1 The polyethylene resin composition C10 was used to manufacture a bottle container and sterilize it under condition 4. The container was evaluated, and the results are shown in Table 10. The component amounts Ht are shown in Table 13 and FIG.

[0094] [Comparative Example 11] Ethylene obtained by blending 95 parts by mass of LL-3 and 5 parts by mass of HD-2 The resin composition C11 was used to manufacture a bottle container and sterilize it under condition 4. The results are shown in Table 11. The amounts Ht are shown in Table 13 and FIG.

[0095] [Comparative Example 12] Ethylene obtained by blending 90 parts by mass of LL-3 and 10 parts by mass of HD-2 The polyethylene resin composition C12 was used to manufacture a bottle container and sterilize it under condition 4. The container was evaluated, and the results are shown in Table 11. The component amounts Ht are shown in Table 13 and FIG.

[0096] [Comparative Example 13] Ethylene obtained by blending 70 parts by mass of LL-5 and 30 parts by mass of LD-2 The polyethylene resin composition C13 was used to manufacture a bottle container and sterilize it under condition 4. The container was evaluated, and the results are shown in Table 11. The component amounts Ht are shown in Table 14 and FIG.

[0097] [Comparative Example 14] Ethylene obtained by blending 70 parts by mass of HD-2 and 30 parts by mass of LD-2 The polyethylene resin composition C14 was used to manufacture a bottle container and sterilize it under condition 4. The container was evaluated, and the results are shown in Table 11. The component amounts Ht are shown in Table 14 and FIG.

[0098] [Comparative Example 15] Ethylene obtained by blending 70 parts by mass of HD-3 and 30 parts by mass of LD-2 Bottle containers were manufactured using the polyethylene resin composition C15 and sterilized under condition 4. The container was evaluated, and the results are shown in Table 11. The component amounts Ht are shown in Table 14 and FIG.

[0099] [Comparative Example 16] Ethylene obtained by blending 95 parts by mass of LL-5 and 5 parts by mass of LD-2 The resin composition C16 was used to manufacture a bottle container and sterilize it under condition 4. The results are shown in Table 11. The amounts Ht are shown in Table 14 and FIG.

[0100] [Table 10]

[0101] [Table 11]

[0102] [Table 12]

[0103] [Table 13]

[0104] [Table 14]

[0105] [Example 23] In Example 1, a blend ratio of 50 parts by mass of LL-1 and 50 parts by mass of LL-5 was used. The resulting ethylene-based resin composition 1 was used to manufacture a bag container having a thickness of 250 μm and Sterilization and container evaluation were carried out under Condition 5. The results are shown in Table 15.

[0106] [Example 24] Using the same ethylene-based resin composition 1 as in Example 23, a bag container with a thickness of 210 μm was produced. Sterilization and container evaluation were also carried out in the same manner. The results are shown in Table 15.

[0107] [Example 25] Using the same ethylene-based resin composition 1 as in Example 23, a bag container with a thickness of 290 μm was produced. Sterilization and container evaluation were also carried out in the same manner. The results are shown in Table 15.

[0108] [Example 26] In Example 6, 45 parts by mass of LL-1, 45 parts by mass of LL-5, and 5 parts by mass of HD-1 were used. LD-1 and LD-2 were blended in a ratio of 5 parts by mass to 5 parts by mass of ethylene-based resin composition 6. The results were as follows: 1. The bag container with a thickness of 250 μm was manufactured, sterilized under condition 6, and the container was evaluated. is shown in Table 15.

[0109] [Example 27] Using the same ethylene-based resin composition 6 as in Example 26, a bag container with a thickness of 210 μm was produced. Sterilization and container evaluation were also carried out in the same manner. The results are shown in Table 15.

[0110] [Example 28] Using the same ethylene-based resin composition 6 as in Example 26, a bag container with a thickness of 290 μm was produced. Sterilization and container evaluation were also carried out in the same manner. The results are shown in Table 15.

[0111] [Comparative Example 17] As the ethylene-based resin composition C17, 100 parts by mass of LL-5 was used, and a thickness of 250 μm was The bag container was manufactured, sterilized under condition 6, and the container was evaluated. The results are shown in Table 16. The melt content Ht of the ethylene resin composition C17 is shown in Table 17 and FIG.

[0112] [Comparative Example 18] Using the ethylene-based resin composition C17, a bag container with a thickness of 210 μm was manufactured under the following conditions: Sterilization and container evaluation were carried out at 6. The results are shown in Table 16.

[0113] [Comparative Example 19] As the ethylene-based resin composition C18, 100 parts by mass of LL-4 was used, and a thickness of 250 μm was The bag container was manufactured, sterilized under condition 5, and the container was evaluated. The results are shown in Table 16. The melt content Ht of the ethylene resin composition C18 is shown in Table 17 and FIG.

[0114] [Comparative Example 21] Manufacture of a 210 μm thick bag container using ethylene-based resin composition C18 and the conditions Sterilization and container evaluation were carried out at 5. The results are shown in Table 16.

[0115] [Table 15]

[0116] [Table 16]

[0117] [Table 17] [Explanation of symbols]

[0118] 10 infusion bottles 11 Torso 12 Shoulder 13 Neck 14 Cap 15 Clamp section 16 Body thickness measurement point 20 infusion bags 21 Liquid storage section (body) 22 Seal part 23 Cylinder member 24 holes 25 Body thickness measurement point

Claims

1. An ethylene-based resin composition simultaneously satisfying the following formulas (1) to (3): An ethylene-based resin composition simultaneously satisfying the following formulas (1) to (3): H ｔ ≦0.0133×e ０．０３５０×ｔ Formula (1) H ｔ ≧0.0025×e ０．０４５０×ｔ Formula (2) (However, if the calculated value of the right side of formula (1) exceeds 1, it is considered to be 1.) 110≦t≦130 Formula (3) (In formulas (1) to (3), t represents the temperature (°C), H ｔ is determined by measuring the endothermic curve of the resin composition using a differential scanning calorimeter (DSC) to measure the endothermic peak, and determining the total heat of fusion ΔH ｍ and the melting temperature t ０ Total heat of fusion from °C to t °C h ｔ is calculated using the following equation (4): H ｔ =h ｔ / ΔH ｍ Formula (4) The melting point of the resin composition at temperature t is calculated by the following formula: Density 895kg / m ３ or more and 920 kg / m ３ 1 to 90 parts by mass of linear low density polyethylene (LLDPE) having a density of 920 kg / m or less ３ or more and 948 kg / m ３ An ethylene-based resin composition comprising a combination of 1 to 90 parts by mass of the following linear low-density polyethylene (LLDPE) and 1 to 5 parts by mass of high-density polyethylene (HDPE) (total of 100 parts by mass of all three).

2. The ethylene-based resin composition according to claim 1, which satisfies the following requirements (a) to (c): (a) Density measured in accordance with JIS K7112 is 900 kg / m ３ More than 980kg / m ３ below, (b) a melt flow rate (MFR) measured in accordance with JIS K7210 at 190°C under a load of 2.16 kg is 0.01 g / 10 min or more and 50 g / 10 min or less; (c) The maximum peak temperature (Tm) of the endothermic curve measured by a differential scanning calorimeter (DSC) is 116°C or higher.

3. A container comprising the ethylene-based resin composition according to claim 1 or 2.

4. 4. The container according to claim 3, which, after high-temperature sterilization at 116°C for 26 minutes, has a transmittance of 55% or more at a wavelength of 450 nm measured by the ultraviolet-visible absorbance measurement method described in Transparency Test Method 1 of the Sixteenth Edition of the Japanese Pharmacopoeia.

5. 5. The container according to claim 3, wherein the average thickness of the body is 0.01 to 1.0 mm.

6. The container according to any one of claims 3 to 5, which has a single layer structure.

7. The container according to any one of claims 3 to 6, which is for medical use or food use.

8. The container according to any one of claims 3 to 7, which is an infusion container.

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