Aerosol generation and delivery systems for carboxylated actives

Abstract

The present invention relates to a delivery system comprising a powered aerosol generation device and an aerosolizable material, wherein the powered aerosol generation device comprises a power source and a controller, and the system comprises a first aerosolizable material and a second aerosolizable material, the second aerosolizable material comprising at least one carboxylated active and stored in the system separately from the first aerosolizable material.

Description

FIELD OF THE INVENTION

[0001] The present invention relates to a delivery system, and components and aerosolizable materials for use in the system.

[0002] Delivery systems that generate aerosols for inhalation by a user are known in the art. In particular, non-flammable aerosol delivery systems that generate aerosols for inhalation by a user are known in the art. Such systems typically include an aerosol generator that can convert an aerosolizable material into an aerosol. In some cases, the aerosol generated is a condensation aerosol, whereby the aerosolizable material is first vaporized and subsequently condensed into an aerosol. In other examples, the aerosol generated is an aerosol resulting from atomization of the aerosolizable material. Such atomization can be effected mechanically, for example, by subjecting the aerosolizable material to vibration to form small particles of the material that are entrained in an airflow. Alternatively, such atomization can be effected electrostatically or by other means, such as by the use of pressure.

[0003] Aerosolizable materials typically contain various components to be delivered to a user, which can be affected by the aerosol generator in different ways depending on the mode of operation of the aerosol generator.

[0004] Ultimately, it is important that such delivery systems and associated aerosolizable materials be designed so that they provide a favorable user experience. Summary of the Invention

[0005] The present invention relates to a delivery system comprising a powered aerosol generating device and an aerosolizable material, wherein the aerosolizable material comprises at least one carboxylated active, and the system is configured to provide selective decarboxylation of the carboxylated active.

[0006] The carboxylated form of some active materials, such as cannabinoids, may have different stability profiles compared to their decarboxylated forms.For example, cannabidiolic acid (CBDA), the carboxylated form of cannabidiol, behaves differently in some solvent systems compared to its decarboxylated form (CBD).On the other hand, this difference in stability can be exploited, since it is possible to utilize a specific form of cannabinoid to achieve a desired stability profile.However, in general, cannabinoids may exert a higher pharmacological effect in their decarboxylated form.Therefore, it may be less desirable to provide cannabinoids in their carboxylated form.However, it is possible to convert cannabinoids from their carboxylated form to their decarboxylated form.

[0007] The present invention provides a system for selective decarboxylation of actives, such as cannabinoids. "Selective decarboxylation of carboxylated actives" means that the system can selectively increase the degree to which decarboxylation of carboxylated actives occurs. This is advantageous because it allows for the control of the stability profile of the active, while also providing benefits that allow for the provision of aerosols with a similar amount of decarboxylation to those that can be obtained from aerosolizable materials that contain only the decarboxylated form of the active.

[0008] In one aspect, the present invention relates to a delivery system comprising a powered aerosol generating device and an aerosolizable material, wherein the powered aerosol generating device comprises a power source and a controller, and the system comprises a first aerosolizable material and a second aerosolizable material, the second aerosolizable material comprising at least one carboxylated active and stored in the system separately from the first aerosolizable material. For the avoidance of doubt, the use of alternative approaches may be combined with other approaches described herein for selective decarboxylation of carboxylated actives.

[0009] Locating the second aerosolizable material separately from the first aerosolizable material can be beneficial for a number of reasons. First, this arrangement can allow the second aerosolizable material to be subjected to selective heating to a temperature below that which heats the first aerosolizable material. For example, the second aerosolizable material can be stored in a second reservoir separate from the reservoir in which the first aerosolizable material is located. In this manner, the second reservoir can be selectively heated (by power from a power source in the device or elsewhere) to promote decarboxylation of the carboxylated active (e.g., cannabinoid) contained therein. One or more heaters can be provided for heating the second aerosolizable material. The second reservoir can contain an internal heater that may be in contact with the second aerosolizable material and / or an external heater that may not be in contact with the second aerosolizable material.

[0010] The degree to which the second reservoir is heated affects the degree of decarboxylation that can occur. For example, a heater (whether internal, external, or both) is configured to heat the second aerosolizable material to a temperature above ambient, but below a temperature at which significant vaporization of the second aerosolizable material can occur. In this regard, the second aerosolizable material can be heated to temperatures above 50°C, above 60°C, above 70°C, above 80°C, above 90°C, above 100°C, above 110°C, above 120°C, above 130°C, above 140°C, or above 145°C, etc. Preferably, the second aerosolizable material is not heated to above 150°C when in the second reservoir. Preferably, the second aerosolizable material is heated to a temperature of 50°C to 150°C, e.g., 50°C to 140°C, 50°C to 130°C, 50°C to 120°C, 50°C to 110°C, 50°C to 100°C, 50°C to 90°C, 50°C to 80°C, or 60°C to 150°C, 70°C to 80°C, 90°C to 150°C, 100°C to 150°C, 110°C to 150°C, 120°C to 150°C, 130°C to 150°C, or 140°C to 150°C.

[0011] The second aerosolizable material can typically be heated to one of the temperatures mentioned above for a certain duration. For example, the second aerosolizable material can be heated to one of the temperatures mentioned above for more than 10 seconds, more than 20 seconds, more than 30 seconds, more than 40 seconds, more than 50 seconds, more than 60 seconds, more than 1 minute, more than 2 minutes, more than 3 minutes, more than 4 minutes, more than 5 minutes, more than 10 minutes, more than 15 minutes, more than 20 minutes, or more than 30 minutes. The total heating time can decrease with increasing temperature. In this regard, the user can select, via the controller, to heat the second aerosolizable material at a higher temperature for a shorter period of time or at a lower temperature for a longer period of time. The exact temperature and length of heating can be determined by the user.

[0012] The first and second reservoirs are fluidly connected. This fluid connection facilitates the transfer of the second aerosolizable material to the first reservoir. The fluid connection can be any one of a wick, a pump, a membrane, etc. The membrane can be useful in that it can be used to allow the passage of the decarboxylated active from the second reservoir to the first reservoir. The user can control the extent to which the transfer of the second aerosolizable material to the first reservoir occurs. For example, the pump can be manually operated by the user, or a powered pump can be controlled to transfer a specific amount of the second aerosolizable material when controlled to do so by the user. In this regard, one or more buttons, switches, touchpads, etc. can be used to control the transfer of the second aerosolizable material to the first reservoir. Alternatively, this transfer can be controlled via another device remotely connected (e.g., wirelessly) to the delivery system device. The fluid connection can also serve to decarboxylate the carboxylated active. For example, the fluid connection can be thermally coupled to one or more heaters. In this manner, the decarboxylating active can be delivered directly to the first reservoir. This approach eliminates the need to heat and decarboxylate the entire second reservoir (and the carboxylating active therein) because only the fluid connection being heated is subjected to decarboxylation.

[0013] Although this embodiment of the invention is typically used with two reservoirs, it is possible to have only a single reservoir containing a single aerosolizable material, in which case the single aerosolizable material contains the carboxylated active, and this single aerosolizable material can be subjected to heat from a dedicated internal and / or external heater (as described above), or heat generated by the aerosol generator can be used.

[0014] Another reason why it may be beneficial to store a second aerosolizable material separately from a first aerosolizable material (in its respective reservoir) is that it allows for the stable storage of an active (such as a cannabinoid) in a higher, possibly much higher, concentration of the carboxylated form than would be possible in the decarboxylated form. As a result, it is possible to use an aerosolizable material having a high concentration of the carboxylated active to supplement the first aerosolizable material. This means that a user can "boost" or simply replenish the carboxylated active content within the first aerosolizable material as desired. Thus, based on the ability to take advantage of in situ decarboxylation, which can be facilitated during aerosolization, a user can stably store an aerosolizable material having a relatively high concentration of the carboxylated active, yet still administer such a material to the first aerosolizable material immediately prior to use. Thus, while heating the second aerosolizable material in the second reservoir can facilitate preemptive decarboxylation, this is not required. This approach is particularly suitable when the active agent is a cannabinoid.

[0015] As previously described, the first and second reservoirs are fluidly connected. This fluid connection facilitates the transfer of the second aerosolizable material to the first reservoir. The fluid connection can be any one of a wick, a pump, a membrane, etc. The user can control the extent to which the transfer of the second aerosolizable material to the first reservoir occurs. For example, the pump can be manually operated by the user, or a powered pump can be controlled to transfer a specific amount of the second aerosolizable material when controlled to do so by the user. In this regard, one or more buttons, switches, touchpads, etc. can be used to control the transfer of the second aerosolizable material to the first reservoir. Alternatively, this transfer can be controlled via another device remotely connected (e.g., wirelessly) to the delivery system device.

[0016] The controller can also be programmed to initiate the delivery of a specific amount of the second aerosolizable material according to a specific schedule, such as delivering a specific amount of the second aerosolizable material, e.g., 0.1 ml, 0.2 ml, 0.3 ml, 0.4 ml, 0.5 ml, 0.6 ml, 0.7 ml, 0.8 ml, 0.9 ml, or 1 ml, on an hourly, daily, weekly, or monthly schedule.

[0017] The controller can also control the transfer of the second aerosolizable material in response to the aerosolization of the first aerosolizable material. For example, the controller can be configured to monitor the instances and / or duration (or a combination thereof) of power supplied to aerosolize the first aerosolizable material and transfer an associated percentage of the second aerosolizable material. In this regard, for a particular system, device, aerosolizable material, and power setting, it is possible to empirically determine the mass loss resulting from the aerosolization of the first aerosolizable material. This mass loss can be used to define the associated percentage of the second aerosolizable material that is transferred. It will be understood that once the second aerosolizable material is transferred to the first reservoir, the second aerosolizable material becomes part of the first aerosolizable material.

[0018] It is also possible (in addition to any one or combination of the preceding implementations for selective decarboxylation) for a second aerosolizable material to be disposed on a substrate disposed within the system, such that the aerosol from the first aerosolizable material contacts the substrate during use. In this regard, particularly if the aerosol is formed by evaporation and subsequent condensation, the substrate will generally be exposed to the aerosol at temperatures significantly above ambient, e.g., greater than 50°C, greater than 60°C, greater than 70°C, greater than 80°C, greater than 90°C, or greater than 100°C. The temperature of the aerosol from the first aerosolizable material allows for decarboxylation of the carboxylated active present on the substrate. The so-decarboxylated active then becomes entrained in the aerosol and can subsequently be inhaled by the user.

[0019] In one example, a user can vary the conditions of interaction between the aerosol from the first aerosolizable material and the substrate. For example, if the aerosol from the first aerosolizable material is generated via a heater, the relative distance between the substrate and the heater can be varied so that the closer the substrate is to the heater, the higher the aerosol temperature to which the aerosol is exposed. It will also be appreciated that, because the substrate may receive radiant heat directly from the heater rather than simply through the aerosol, moving the substrate closer to the heater will also increase the degree of radiant heating.

[0020] The degree to which the aerosol interacts with the substrate can also be varied. In some cases, substantially all of the aerosol from the first aerosolizable material passes through the substrate. In other cases, some or substantially all of the aerosol from the first aerosolizable material can bypass the substrate. Thus, the user can control the degree to which the substrate is exposed to the aerosol and heater.

[0021] In another embodiment, the aerosol generating device comprises a power source, such as an electrical power source, a controller, and at least one aerosol generator configured to aerosolize an aerosolizable material to form an inhalable aerosol, wherein the controller is configured to facilitate delivery of power to the aerosol generator at more than one power level. The aerosol generator can be a heater. For the avoidance of doubt, the use of alternative approaches for selective decarboxylation of carboxylated actives can be combined with other approaches described herein for selective decarboxylation of carboxylated actives.

[0022] During use, the presence of a controller with variable power delivery to the aerosol generator (e.g., heater) allows the user to operate the system to control the degree of in situ conversion of the carboxylated form to the decarboxylated form. Because the in situ conversion rate for some cannabinoids is generally temperature-dependent (see, "Cannabis and Cannabinoid Research. Volume 1.1, 2016, Decarboxylation Study of Acidic Cannabinoids: A Novel Approach Using Ultra-High-Performance Supercritical Fluid Chromatography / Photodiode Array-Mass Spectrometry"), supplying higher power to the aerosol generator, e.g., heater, will generally result in higher local temperatures at the heater, which will generally result in greater conversion from the carboxylated form to the decarboxylated form. Thus, the user can control the system to provide aerosols with varying amounts of the decarboxylated active. For example, if the carboxylated active is CBDA, the user can control the system to provide aerosols with varying amounts of CBD.

[0023] The controller can be configured to facilitate the delivery of power to the aerosol generator (e.g., heater) at more than one power level in various ways. For example, the controller can be configured to deliver power to the heater according to a "normal" power profile and an "increased" power profile. The normal power profile corresponds to the power profile typically delivered to the heater of a device when a user does not specifically desire an increased content of decarboxylated active in the subsequent aerosol. The increased power profile corresponds to power above a certain threshold power, which is power above the power applied during the normal power profile.

[0024] In practice, the aerosolizable material may already contain some decarboxylating active (e.g., cannabinoid), and thus a normal power profile will produce an aerosol having a "baseline" amount of decarboxylating active (e.g., cannabinoid). The exact power to deliver during such a normal power profile will be system specific. Furthermore, the exact power to deliver during an increased power profile may depend on the concentration of carboxylating active in the aerosolizable material, as well as the efficiency of energy transfer from the aerosol generator to the aerosolizable material. For any particular system and aerosolizable material, the increased power profile may be set to achieve a particular level (or minimum level) of decarboxylation above the "baseline" resulting from the normal power profile. However, an increased power profile typically corresponds to power equal to or greater than a threshold power, which represents an increase in power of more than 5%, 10%, 15%, 20%, 25%, 30%, 35%, 40%, 45%, 50%, 60%, 70%, 80%, 90%, 100%, 110%, 120%, 130%, 140%, 150%, 160%, 170%, 180%, 190%, or 200% compared to the power applied during the normal power profile. For example, if the normal power profile for a particular system is 3 W, then the increased power profile may be greater than 4.5 W (which may represent an increase in power of more than 50%). Another example may be that if the normal power profile for a particular system is 5W, the increased power profile may be greater than 12W (which may represent a power increase of over 100%).

[0025] It will be appreciated that the device may generally be activated to provide a regular power profile in a variety of ways, for example, the device may be puff actuated (in the sense that a sensor detects the presence of inhalation, e.g., by a change in pressure or airflow), or the device may be manually actuated by a button, switch, touchpad, etc.

[0026] To enable the controller to deliver power to the heater according to an increased power profile, the controller can be configured to respond to a specific input indicating a desire for such an increased power profile. For example, the device may include a button, switch, touchpad, etc., and the controller can detect user activation of the button, switch, touchpad, etc. The button, switch, touchpad, etc. may be intended to provide an “increased” power profile. Alternatively, the controller can be programmed to detect a specific profile of activating an existing button, switch, touchpad, etc. and recognize this specific activation profile as an instruction to deliver an increased power profile. The specific activation profile associated with an increased power profile is typically different from an activation profile that delivers a normal power profile. This allows the controller to distinguish between activations intended to result in a normal power profile or an increased power profile. For example, a specific activation profile for an “increased” power profile may include a specific number of activations or “taps” of a button, switch, touchpad, etc., such as two or three taps in short succession, e.g., within one or two seconds of each other.

[0027] Alternatively, a particular actuation profile associated with an increased power profile corresponds to a particular actuation pressure, e.g., actuation for a particular pressure threshold. The increased power applied can also be proportional to the applied pressure. This allows for a correlation between the degree of actuation and the power delivered to the aerosol generator (e.g., heater), thereby allowing for intuitive application of the increased power profile.

[0028] The controller may be configured to apply the increased power profile for the current inhalation, the next inhalation, and / or all subsequent inhalations.

[0029] The controller may be configured to limit its ability to apply an increased power profile according to a predetermined schedule. For example, an increased power profile may be "available" to a user only after a certain time of day or based on certain prior usage patterns of the system. In such circumstances, the controller would be configured to ignore certain operating profiles associated with the "increased" power profile. The predetermined schedule may be set by the user via this device or via a remote device in communication with the devices of the system described elsewhere.

[0030] Alternatively, the controller can be configured to automatically apply the increased power profile according to a predetermined schedule. For example, the increased power profile can be activated after a certain time of day or based on a certain historical usage pattern of the system. In such a situation, the controller will apply the increased power profile in all instances of aerosol generation according to the schedule.

[0031] The controller may be configured to store a range of power level settings for increased power profiles, allowing the user to access and select the desired higher setting for a particular inhalation. Such selection may be made via a button, switch, touchpad, etc. on the device. The power level may be adjusted via another device that is separate from but capable of communicating with the delivery system device; for example, the power level may be adjusted via an app running on a smartphone or tablet, which will communicate with the delivery system device to update the power setting.

[0032] The aerosol generator is typically a heater. When the aerosol generator is a heater, the temperature at the heater is generally affected by the power supplied to the heater, so higher power will promote a higher heater temperature. Those skilled in the art will recognize that other factors, such as the airflow through the heater or the rate at which the aerosolizable material can be displaced at a location near the heater, can affect the exact temperature of the heater. In some embodiments, it is contemplated that the system allows for variation in the airflow through the aerosol generator (e.g., heater) and / or variation in the rate of delivery of the aerosolizable material to the aerosol generator (e.g., heater). One way to vary the airflow would be to modify the total area of ​​one or more air inlets of the system. This can be done via a shutter or the like. One way to vary the rate of delivery of the aerosolizable material to the aerosol generator would be to use a pump with a different flow rate.

[0033] An alternative approach that the system can provide for selective decarboxylation of carboxylated actives is to configure the system to deliver puffs for various lengths of time. It has been found that longer puffs can result in a greater relative percentage of decarboxylated actives in the aerosol. By configuring the system to deliver puffs of a certain length, it is possible to selectively influence the degree of decarboxylation. Thus, the device can be preconfigured to deliver a certain puff length (allowing the user to vary the preconfigured puff length to increase decarboxylation), and / or the device can be configured to encourage the user to puff for a certain length of time to influence the degree of decarboxylation.

[0034] In a further aspect, an article is provided that includes an aerosolizable material, the aerosolizable material including at least one carboxylated active present.

[0035] The article may include at least one first reservoir for containing an aerosolizable material. The article may include first and second containers for containing first and second aerosolizable materials described herein.

[0036] The aerosolizable material(s) generally comprise one or more carboxylated actives, a carrier component, and optionally one or more flavorings. Generally, the aerosolizable material(s) are in the form of a liquid. It will be understood that the liquid may be held free in the reservoir of the device or may be held in a carrier.

[0037] As previously described, the aerosolizable material(s) contain at least one carboxylated active agent. In some embodiments, the substance to be delivered comprises an active agent.

[0038] As used herein, an active substance can be a bioactive material, which is a material intended to achieve or enhance a physiological response. The active substance can be selected from, for example, dietary supplements, nootropics, and psychotropic drugs. The active substance can be naturally occurring or synthetically derived. The active substance can include, for example, nicotine, caffeine, taurine, theine, vitamins such as B6, B12, or C, melatonin, cannabinoids, or components, derivatives, or combinations thereof. The active substance can include one or more components, derivatives, or extracts of tobacco, hemp, or another botanical material.

[0039] In one embodiment, the active substance is a legally permitted recreational drug.

[0040] In some embodiments, the active agent comprises nicotine. In some embodiments, the active agent comprises caffeine, melatonin, or vitamin B12. In some embodiments, the active agent comprises a cannabinoid. Preferably, the carboxylated active agent is a carboxylated cannabinoid.

[0041] Cannabinoids are a class of natural or synthetic compounds that act on cannabinoid receptors (i.e., CB1 and CB2) in cells of the brain, inhibiting the release of neurotransmitters. Cannabinoids are cyclic molecules that exhibit certain properties, such as the ability to easily cross the blood-brain barrier. Cannabinoids can be naturally occurring from plants such as cannabis (phytocannabinoids), naturally occurring from animals (endocannabinoids), or artificially produced (synthetic cannabinoids).

[0042] Cannabis species express at least 85 different phytocannabinoids, which are classified into subclasses including cannabigerol, cannabichromene, cannabidiol, tetrahydrocannabinol, cannabinol, and cannabinodiol, as well as other cannabinoids, such as cannabigerol (CBG), cannabigerolic acid (CBGA), cannabichromene (CBC), cannabichromenic acid (CBCA), cannabidiol (CBD), cannabidiolic acid (CBDA), and isomers Δ 6a,10a -Tetrahydrocannabinol (Δ 6a,10a -THC), Δ 6a(7) -Tetrahydrocannabinol (Δ 6a(7) -THC), Δ 8 -Tetrahydrocannabinol (Δ 8 -THC), Δ 9 -Tetrahydrocannabinol (Δ 9 -THC), Δ 10 -Tetrahydrocannabinol (Δ 10 -THC), Δ 9,11 -Tetrahydrocannabinol (Δ 9,11-THC), tetrahydrocannabinol (THC), tetrahydrocannabinolic acid (THCA), cannabinol (CBN), cannabinolic acid (CBNA), and cannabinodiol (CBDL), cannabicyclol (CBL), cannabivarin (CBV), tetrahydrocannabivarin (THCV), cannabidivarin (CBDV), cannabichromevarin (CBCV), cannabigerovarin (CBGV), and cannabigerol monomethyl ether (CBGM).

[0043] Naturally occurring cannabinoids generally exist in their carboxylated form. In this regard, cannabidiol (CBD) and cannabidiolic acid (CBDA) are the decarboxylated and carboxylated forms, respectively.

[0044] [ka] [ka]

[0045] The carboxylated cannabinoids referred to herein may be any carboxylated form of the decarboxylated cannabinoids referred to above. Preferably, the carboxylated cannabinoids are cannabigerolic acid (CBGA), cannabichromene acid (CBCA), cannabinolic acid (CBNA), tetrahydrocannabinolic acid (THCA), cannabidiolic acid (CBDA), and combinations thereof. Preferably, the decarboxylated cannabinoids are cannabigerol (CBG), cannabichromene (CBC), cannabinol (CBN), tetrahydrocannabinol (THC), cannabidiol (CBD), and combinations thereof.

[0046] The aerosolizable material(s) may also contain one or more other actives in decarboxylated form. Preferably, the one or more other actives are cannabinoids. Preferably, the one or more other cannabinoids are decarboxylated forms of carboxylated cannabinoids. Thus, if the aerosolizable material contains CBDA, the aerosolizable material may also contain CBD. Preferably, the aerosolizable material contains CBDA and CBD. However, the other actives may be decarboxylated cannabinoids that do not result from decarboxylation of a carboxylated cannabinoid present in the aerosolizable formulation.

[0047] In some embodiments, the aerosolizable material comprising at least one carboxylated cannabinoid may also comprise one or more of cannabigerol (CBG), cannabichromene (CBC), cannabidiol (CBD), tetrahydrocannabinol (THC), and cannabinol (CBN). In some embodiments, the aerosolizable material comprises cannabidiolic acid (CBDA) and at least one decarboxylated cannabinoid selected from the group consisting of cannabigerol (CBG), cannabichromene (CBC), cannabidiol (CBD), tetrahydrocannabinol (THC), and cannabinol (CBN). In one embodiment, the aerosolizable material comprises cannabidiolic acid (CBDA) and tetrahydrocannabinol (THC).

[0048] The molar ratio of each of the carboxylated / decarboxylated forms of the active in the aerosolizable material can vary. For example, the molar ratio of the carboxylated active to its corresponding decarboxylated active can be from 99:1 to 1:99. Preferably, the active is a cannabinoid, and the molar ratio of the carboxylated cannabinoid to its corresponding decarboxylated cannabinoid can be from 99:1 to 1:99. Specific ratios in this regard can be 10:1, 9:1, 8:1, 7:1, 6:1, 5:1, 4:1, 3:1, 2:1, 1:1, 1:2, 1:3, 1:4, or 1:5. Preferably, the carboxylated form is present in molar excess over the decarboxylated form.

[0049] The cannabinoids can be synthetic or naturally derived. In one embodiment, the cannabinoids are present in the form of an isolate. An isolate is an extract from a plant, such as cannabis, in which the active substance of interest (in this case, a cannabinoid such as CBDA) is present in a highly pure form, for example, greater than 95%, greater than 96%, greater than 97%, greater than 98%, or about 99% pure.

[0050] Cannabinoids (whether carboxylated or decarboxylated) may be present in the aerosolizable material on a mg / ml basis of the aerosolizable material. References below to "the" cannabinoid refer to each cannabinoid present in the aerosolizable material individually, whether carboxylated or not. Although the amounts below are set forth in the context of cannabinoids, each of the following ranges may equally apply to the other actives (carboxylated or decarboxylated) referred to herein.

[0051] In one embodiment, the cannabinoid is present in an amount of about 5 mg / ml to about 200 mg / ml. In one embodiment, the cannabinoid is present in an amount of about 5 mg / ml to about 150 mg / ml. In one embodiment, the cannabinoid is present in an amount of about 5 mg / ml to about 90 mg / ml. In one embodiment, the cannabinoid is present in an amount of about 5 mg / ml to about 80 mg / ml. In one embodiment, the cannabinoid is present in an amount of about 5 mg / ml to about 70 mg / ml. In one embodiment, the cannabinoid is present in an amount of about 5 mg / ml to about 60 mg / ml. In one embodiment, the cannabinoid is present in an amount of about 5 mg / ml to about 50 mg / ml. In one embodiment, the cannabinoid is present in an amount of about 5 mg / ml to about 40 mg / ml. In one embodiment, the cannabinoid is present in an amount of about 5 mg / ml to about 30 mg / ml. In one embodiment, the cannabinoid is present in an amount of from about 5 mg / ml up to about 20 mg / ml. In one embodiment, the cannabinoid is present in an amount of from about 5 mg / ml up to about 10 mg / ml.

[0052] In one embodiment, the cannabinoid is present in an amount of about 5 mg / ml or greater. In one embodiment, the cannabinoid is present in an amount of about 10 mg / ml or greater. In one embodiment, the cannabinoid is present in an amount of about 15 mg / ml or greater. In one embodiment, the cannabinoid is present in an amount of about 20 mg / ml or greater. In one embodiment, the cannabinoid is present in an amount of about 25 mg / ml or greater. In one embodiment, the cannabinoid is present in an amount of about 30 mg / ml or greater. In one embodiment, the cannabinoid is present in an amount of about 35 mg / ml or greater. In one embodiment, the cannabinoid is present in an amount of about 40 mg / ml or greater. In one embodiment, the cannabinoid is present in an amount of about 45 mg / ml or greater. In one embodiment, the cannabinoid is present in an amount of about 50 mg / ml or greater. In one embodiment, the cannabinoid is present in an amount of about 55 mg / ml or greater. In one embodiment, the cannabinoid is present in an amount of about 60 mg / ml or greater. In one embodiment, the cannabinoid is present in an amount of about 65 mg / ml or greater.

[0053] The total amount of all actives present in the or each aerosolizable material may be 200 mg / ml.

[0054] The total amount of all cannabinoids present in the or each aerosolizable material may be 200 mg / ml.

[0055] The carrier component comprises one or more components capable of forming an aerosol, particularly when evaporated and condensed. In some embodiments, the carrier component may comprise one or more of glycerol, propylene glycol, triethylene glycol, tetraethylene glycol, 1,3-butylene glycol, erythritol, meso-erythritol, ethyl vanillate, ethyl laurate, diethyl suberate, triethyl citrate, triethylene glycol diacetate, triacetin, diacetin mixtures, benzyl benzoate, benzyl phenylacetate, tributyrin, lauryl acetate, lauric acid, myristic acid, and propylene carbonate. Preferably, the carrier component comprises propylene glycol and / or glycerol.

[0056] In one embodiment, propylene glycol is present in an amount of 10% w / w to 95% w / w based on the total weight of the aerosolizable material. In one embodiment, propylene glycol is present in an amount of 20% w / w to 95% w / w based on the total weight of the material. In one embodiment, propylene glycol is present in an amount of 30% w / w to 95% w / w based on the total weight of the material. In one embodiment, propylene glycol is present in an amount of 40% w / w to 95% w / w based on the total weight of the material.

[0057] In one embodiment, propylene glycol is present in an amount of 50% w / w to 90% w / w based on the total weight of the ingredients. In one embodiment, propylene glycol is present in an amount of 50% w / w to 85% w / w based on the total weight of the ingredients. In one embodiment, propylene glycol is present in an amount of 50% w / w to 80% w / w based on the total weight of the ingredients. In one embodiment, propylene glycol is present in an amount of 50% w / w to 75% w / w based on the total weight of the ingredients. In one embodiment, propylene glycol is present in an amount of 50% w / w to 60% w / w based on the total weight of the ingredients. In one embodiment, propylene glycol is present in an amount of 50% w / w to 65% w / w based on the total weight of the ingredients. In one embodiment, propylene glycol is present in an amount of 50% w / w to 60% w / w based on the total weight of the ingredients.

[0058] In one embodiment, propylene glycol is present in an amount of 55% w / w to 90% w / w based on the total weight of the ingredients. In one embodiment, propylene glycol is present in an amount of 60% w / w to 90% w / w based on the total weight of the ingredients. In one embodiment, propylene glycol is present in an amount of 65% w / w to 90% w / w based on the total weight of the ingredients. In one embodiment, propylene glycol is present in an amount of 70% w / w to 90% w / w based on the total weight of the ingredients. In one embodiment, propylene glycol is present in an amount of 75% w / w to 90% w / w based on the total weight of the ingredients. In one embodiment, propylene glycol is present in an amount of 80% w / w to 90% w / w based on the total weight of the ingredients. In one embodiment, propylene glycol is present in an amount of 85% w / w to 90% w / w based on the total weight of the ingredients.

[0059] In one embodiment, propylene glycol is present in an amount of at least 10% w / w based on the total weight of the ingredients. In one embodiment, propylene glycol is present in an amount of at least 20% w / w based on the total weight of the ingredients. In one embodiment, propylene glycol is present in an amount of at least 30% w / w based on the total weight of the ingredients. In one embodiment, propylene glycol is present in an amount of at least 40% w / w based on the total weight of the ingredients. In one embodiment, propylene glycol is present in an amount of at least 50% w / w based on the total weight of the ingredients. In one embodiment, propylene glycol is present in an amount of at least 55% w / w based on the total weight of the ingredients. In one embodiment, propylene glycol is present in an amount of at least 60% w / w based on the total weight of the ingredients. In one embodiment, propylene glycol is present in an amount of at least 65% w / w based on the total weight of the ingredients. In one embodiment, propylene glycol is present in an amount of at least 70% w / w based on the total weight of the ingredients. In one embodiment, propylene glycol is present in an amount of at least 75% w / w based on the total weight of the ingredients. In one embodiment, propylene glycol is present in an amount of at least 80% w / w based on the total weight of the ingredients. In one embodiment, propylene glycol is present in an amount of at least 85% w / w based on the total weight of the ingredients. In one embodiment, propylene glycol is present in an amount of at least 90% w / w based on the total weight of the ingredients.

[0060] In one embodiment, the carrier component comprises glycerol. In one embodiment, the glycerol is present in an amount of 10% w / w to 95% w / w based on the total weight of the ingredients. In one embodiment, the glycerol is present in an amount of 20% w / w to 95% w / w based on the total weight of the ingredients. In one embodiment, the glycerol is present in an amount of 30% w / w to 95% w / w based on the total weight of the ingredients. In one embodiment, the glycerol is present in an amount of 40% w / w to 95% w / w based on the total weight of the ingredients. In one embodiment, the glycerol is present in an amount of 50% w / w to 95% w / w based on the total weight of the ingredients.

[0061] In one embodiment, glycerol is present in an amount of 50% to 90% w / w based on the total weight of the ingredients. In one embodiment, glycerol is present in an amount of 50% to 85% w / w based on the total weight of the ingredients. In one embodiment, glycerol is present in an amount of 50% to 80% w / w based on the total weight of the ingredients. In one embodiment, glycerol is present in an amount of 50% to 75% w / w based on the total weight of the ingredients. In one embodiment, glycerol is present in an amount of 50% to 60% w / w based on the total weight of the ingredients. In one embodiment, glycerol is present in an amount of 50% to 65% w / w based on the total weight of the ingredients. In one embodiment, glycerol is present in an amount of 50% to 60% w / w based on the total weight of the ingredients.

[0062] In one embodiment, glycerol is present in an amount of 55% w / w to 90% w / w based on the total weight of the ingredients. In one embodiment, glycerol is present in an amount of 60% w / w to 90% w / w based on the total weight of the ingredients. In one embodiment, glycerol is present in an amount of 65% w / w to 90% w / w based on the total weight of the ingredients. In one embodiment, glycerol is present in an amount of 70% w / w to 90% w / w based on the total weight of the ingredients. In one embodiment, glycerol is present in an amount of 75% w / w to 90% w / w based on the total weight of the ingredients. In one embodiment, glycerol is present in an amount of 80% w / w to 90% w / w based on the total weight of the ingredients. In one embodiment, glycerol is present in an amount of 85% w / w to 90% w / w based on the total weight of the ingredients.

[0063] In one embodiment, glycerol is present in an amount of at least 10% w / w based on the total weight of the ingredients. In one embodiment, glycerol is present in an amount of at least 20% w / w based on the total weight of the ingredients. In one embodiment, glycerol is present in an amount of at least 30% w / w based on the total weight of the ingredients. In one embodiment, glycerol is present in an amount of at least 40% w / w based on the total weight of the ingredients. In one embodiment, glycerol is present in an amount of at least 50% w / w based on the total weight of the ingredients. In one embodiment, glycerol is present in an amount of at least 50% w / w based on the total weight of the ingredients. In one embodiment, glycerol is present in an amount of at least 55% w / w based on the total weight of the ingredients. In one embodiment, glycerol is present in an amount of at least 60% w / w based on the total weight of the ingredients. In one embodiment, glycerol is present in an amount of at least 65% w / w based on the total weight of the ingredients. In one embodiment, glycerol is present in an amount of at least 70% w / w based on the total weight of the ingredients. In one embodiment, glycerol is present in an amount of at least 75% w / w based on the total weight of the ingredients. In one embodiment, glycerol is present in an amount of at least 80% w / w based on the total weight of the ingredients. In one embodiment, glycerol is present in an amount of at least 85% w / w based on the total weight of the ingredients. In one embodiment, glycerol is present in an amount of at least 90% w / w based on the total weight of the ingredients.

[0064] In one embodiment, glycerol and propylene glycol are both present as carrier components. In one embodiment, glycerol and propylene glycol are present in the aerosolizable material in the following amounts, based on the total weight of glycerol and propylene glycol present in the material: 60-90% w / w propylene glycol, and 40-10% w / w glycerol It exists in.

[0065] In one embodiment, glycerol and propylene glycol are present in the aerosolizable material in the following amounts, based on the total weight of glycerol and propylene glycol present in the material: 70-80% w / w propylene glycol, and 30-20% w / w glycerol It exists in.

[0066] In one embodiment, the aerosolizable material comprises about 70% w / w propylene glycol and about 30% glycerol.

[0067] In one embodiment, the aerosolizable material is a liquid at about 25°C.

[0068] The aerosolizable material may comprise one or more additional components. In particular, the one or more additional components may be selected from one or more physiologically and / or olfactorily active components and / or one or more functional components.

[0069] In some embodiments, the active component is an olfactory-active component and, where local regulations permit, may be selected from "fragrances" and / or "flavorings" that may be used to create a desired taste, scent, or sensation in a product for adult consumers. In some cases, such components may be referred to as fragrances, flavorings, coolants, heatants, or sweeteners, and may include extracts (e.g., licorice, hydrangea, magnolia leaf, chamomile, fenugreek, clove, menthol, mint, aniseed, cinnamon, herbs, wintergreen, cherry, berry, peach, apple, Drambuie, bourbon, Scotch, whiskey, spearmint, peppermint, lavender, cardamom, celery, cascarilla, nutmeg, sandalwood, bergamot, geranium, honey essence, rose oil, vanilla, lemon oil, orange oil, cassia, kimchi, cinnamon, herbs, wintergreen, cherry, berry, peach, apple, Drambuie, bourbon, scot ... The compositions may include one or more of the following: charaway, cognac, jasmine, ylang-ylang, sage, fennel, bell pepper, ginger, anise, coriander, coffee, or mint oil from any species of the mint genus), flavor enhancers, bitter taste receptor site blockers, sensory receptor site activators or stimulants, sugars and / or sugar substitutes (e.g., sucralose, acesulfame potassium, aspartame, saccharin, cyclamate, lactose, sucrose, glucose, fructose, sorbitol, or mannitol), and other additives such as charcoal, chlorophyll, minerals, botanicals, or breath fresheners. The components may be imitation, synthetic, or natural ingredients, or blends thereof. The components may be in any suitable form, such as oils, liquids, or powders.

[0070] The perfume can be added to the aerosolizable material as part of a so-called "perfume block," in which one or more perfumes are blended together and then added to the aerosolizable material.

[0071] In some embodiments, the olfactory-active component comprises a terpene. In some embodiments, the terpene is a terpene derivable from a phytocannabinoid-producing plant, such as a plant from the Cannabis sativa species, such as hemp. In some embodiments, the aerosolizable material comprises a cannabinoid isolate in combination with a terpene derivable from a phytocannabinoid-producing plant.

[0072] Suitable terpenes in this regard include so-called "C10" terpenes, which are terpenes containing 10 carbon atoms. Suitable terpenes in this regard also include so-called "C15" terpenes, which are terpenes containing 15 carbon atoms. In some embodiments, the aerosolizable material comprises more than one terpene. For example, the aerosolizable material may comprise one, two, three, four, five, six, seven, eight, nine, ten, or more terpenes, as defined herein.

[0073] In some embodiments, the aerosolizable material comprises a combination of terpenes. In some embodiments, the combination of terpenes may comprise at least a combination of geraniol and linalool. In some embodiments, the combination of terpenes may comprise at least a combination of eucalyptol and menthone. In some embodiments, the combination of terpenes may comprise at least a combination of eucalyptol, carvone, piperitone, and menthone. In some embodiments, the combination of terpenes may comprise at least a combination of eucalyptol, carvone, beta-bourbonene, germacrene, piperitone, iso-menthone, and menthone.

[0074] In one embodiment, the terpene(s) are present in a perfume block. This means that the terpene is blended with one or more other perfumes (optionally with a suitable solvent, e.g., propylene glycol), and then the perfume block is added during the preparation of the aerosolizable material. In some embodiments, the total amount of perfume block(s) present in the aerosolizable material is up to about 10 wt%. In some embodiments, the total amount of perfume block(s) present in the aerosolizable material is up to about 9 wt%. In some embodiments, the total amount of perfume block(s) present in the aerosolizable material is up to about 8 wt%. In some embodiments, the total amount of perfume block(s) present in the aerosolizable material is up to about 7 wt%. In some embodiments, the total amount of perfume block(s) present in the aerosolizable material is up to about 6 wt%. In some embodiments, the total amount of perfume block(s) present in the aerosolizable material is up to about 5 wt%.

[0075] In one embodiment, the total amount of terpenes present in the aerosolizable material is at most about 10 mg / ml. In one embodiment, the total amount of terpenes present in the aerosolizable material is at most about 9 mg / ml. In one embodiment, the total amount of terpenes present in the aerosolizable material is at most about 8 mg / ml. In one embodiment, the total amount of terpenes present in the aerosolizable material is at most about 7 mg / ml. In one embodiment, the total amount of terpenes present in the aerosolizable material is at most about 6 mg / ml. In one embodiment, the total amount of terpenes present in the aerosolizable material is at most about 5 mg / ml. In one embodiment, the total amount of terpenes present in the aerosolizable material is at most about 4 mg / ml. In one embodiment, the total amount of terpenes present in the aerosolizable material is at most about 3 mg / ml. In one embodiment, the total amount of terpenes present in the aerosolizable material is at most about 2 mg / ml. In one embodiment, the total amount of terpenes present in the aerosolizable material is at most about 1 mg / ml.

[0076] In one embodiment, the total amount of terpenes present in the aerosolizable material is from about 0.1 mg / ml to about 10 mg / ml. In one embodiment, the total amount of terpenes present in the aerosolizable material is from about 0.2 mg / ml to about 10 mg / ml. In one embodiment, the total amount of terpenes present in the aerosolizable material is from about 0.3 mg / ml to about 10 mg / ml. In one embodiment, the total amount of terpenes present in the aerosolizable material is from about 0.4 mg / ml to about 10 mg / ml. In one embodiment, the total amount of terpenes present in the aerosolizable material is from about 0.5 mg / ml to about 10 mg / ml. In one embodiment, the total amount of terpenes present in the aerosolizable material is from about 1.0 mg / ml to about 10 mg / ml. In one embodiment, the total amount of terpenes present in the aerosolizable material is from about 2.0 mg / ml to about 10 mg / ml. In one embodiment, the total amount of terpenes present in the aerosolizable material is from about 3.0 mg / ml to about 10 mg / ml. In one embodiment, the total amount of terpenes present in the aerosolizable material is from about 4.0 mg / ml to about 10 mg / ml. In one embodiment, the total amount of terpenes present in the aerosolizable material is from about 5.0 mg / ml to about 10 mg / ml.

[0077] In one embodiment, the total amount of terpenes present in the aerosolizable material is from about 0.1 mg / ml to about 9.0 mg / ml. In one embodiment, the total amount of terpenes present in the aerosolizable material is from about 0.1 mg / ml to about 8.0 mg / ml. In one embodiment, the total amount of terpenes present in the aerosolizable material is from about 0.1 mg / ml to about 7.0 mg / ml. In one embodiment, the total amount of terpenes present in the aerosolizable material is from about 0.1 mg / ml to about 6.0 mg / ml. In one embodiment, the total amount of terpenes present in the aerosolizable material is from about 0.1 mg / ml to about 5.0 mg / ml. In one embodiment, the total amount of terpenes present in the aerosolizable material is from about 0.1 mg / ml to about 1 mg / ml. In one embodiment, the total amount of terpenes present in the aerosolizable material is from about 0.1 mg / ml to about 0.9 mg / ml. In one embodiment, the total amount of terpenes present in the aerosolizable material is from about 0.1 mg / ml to about 0.8 mg / ml. In one embodiment, the total amount of terpenes present in the aerosolizable material is from about 0.1 mg / ml to about 0.7 mg / ml. In one embodiment, the total amount of terpenes present in the aerosolizable material is from about 0.1 mg / ml to about 0.6 mg / ml. In one embodiment, the total amount of terpenes present in the aerosolizable material is from about 0.1 mg / ml to about 0.5 mg / ml.

[0078] For the avoidance of doubt, combinations of the above endpoints are expressly contemplated by this disclosure, as are any of the ranges disclosed herein.

[0079] The one or more other functional components may include one or more of a pH adjuster, a colorant, a preservative, a binder, a filler, a stabilizer, and / or an antioxidant. In particular, the pH adjuster may include one or more acids selected from organic acids or inorganic acids. An example of an inorganic acid is phosphoric acid. The organic acid may include a carboxylic acid. In one embodiment, the carboxylic acid may be any suitable carboxylic acid. In one embodiment, the acid is a monocarboxylic acid. In one embodiment, the acid may be selected from the group consisting of acetic acid, lactic acid, formic acid, citric acid, benzoic acid, pyruvic acid, levulinic acid, succinic acid, tartaric acid, oleic acid, sorbic acid, propionic acid, phenylacetic acid, and mixtures thereof.

[0080] The aerosolizable material may also include water. For example, water may be present in an amount of up to 10% w / w, based on the total weight of the aerosolizable material. In one embodiment, water is present in the aerosolizable material in an amount of up to about 5% w / w. In one embodiment, water is present in the aerosolizable material in an amount of up to about 3% w / w. In one embodiment, water is present in the aerosolizable material in an amount of about 1% w / w. In one embodiment, water is present in the aerosolizable material in an amount of about 1% w / w. In one embodiment, water is present in the aerosolizable material in an amount of about 2% w / w. In one embodiment, water is present in the aerosolizable material in an amount of about 3% w / w. In one embodiment, water is present in the aerosolizable material in an amount of about 4% w / w. In one embodiment, water is present in the aerosolizable material in an amount of about 5% w / w.

[0081] It has been proposed that the presence of some water may facilitate the decarboxylation process.

[0082] In one embodiment, the aerosolizable material comprises, based on the total weight of the material: 1% to 10% w / w of carboxylated actives, 60-80% w / w propylene glycol, 20% to 30% w / w glycerol, and 0% to 10% w / w water may include:

[0083] In one embodiment, the aerosolizable material comprises, based on the total weight of the material: about 5% w / w carboxylated actives, about 70% w / w propylene glycol, about 25% w / w glycerol, and 0% w / w water may include:

[0084] In one embodiment, the aerosolizable material comprises, based on the total weight of the material: about 5% w / w carboxylated actives, about 70% w / w propylene glycol, about 22% w / w glycerol, and 3% w / w water may include:

[0085] It may be advantageous to use a water-containing formulation in a device configured to deliver certain, for example, lower power to the aerosolizable formulation. Thus, in one embodiment, a delivery system is provided comprising a powered aerosol generating device and an aerosolizable material, wherein the aerosolizable material comprises at least one carboxylated active and water, and the powered aerosol generating device is configured to deliver less than 12 W per puff to the aerosolizable material. In one embodiment, the powered aerosol generating device is configured to deliver less than 11 W, 10 W, 9 W, 8 W, 7 W, 6 W, or 5 W to the aerosolizable material.

[0086] Also provided is an aerosolizable material as defined herein. In particular, any of the components and their respective amounts described herein can be used to characterize the aerosolizable material. [Brief explanation of the drawings]

[0087] [Figure 1] 1 is a schematic diagram (not to scale) of an exemplary delivery system such as an e-cigarette according to the present disclosure. [Figure 2] 1 provides a schematic diagram of a portion of an airflow channel through an aerosol delivery system described herein. [Figure 2A] 1 provides a schematic diagram of a removable segment according to the present disclosure. [Figure 3] 1 provides a schematic diagram of a portion of an airflow channel through an aerosol delivery system described herein. [Figure 4] 1 provides a schematic diagram of an aerosol delivery system in which a first reservoir and a second reservoir are disposed. Detailed Description

[0088] 1 is a highly schematic illustration (not to scale) of an exemplary delivery system to which embodiments are applicable, such as an e-cigarette 10. The e-cigarette has a generally cylindrical shape extending along a longitudinal axis indicated by the dashed line (although aspects of the invention are applicable to e-cigarettes constructed of other shapes and configurations), and comprises two main components: an aerosol delivery device 20 and an article 30.

[0089] Article 30 includes a storage or reservoir for aerosolizable material (feed liquid) 38 from which the aerosol is generated. Article 30 further includes an aerosol generating component (such as a heating element or heater) 36 for heating the aerosolizable material to generate the aerosol. A transport or wicking element or wick 37 is provided to deliver the aerosolizable material from storage 38 to heating element 36. A portion or portions of wick 37 are in fluid communication with the aerosolizable material in storage 38, and by wicking or capillary action, the aerosolizable material is drawn along or through wick 37 to a portion or portions of wick 37 that are in contact with heater 36. Those skilled in the art will appreciate that other modes of transporting the liquid to the heater, such as pumping, dripping, etc., may be used.

[0090] Vaporization of the aerosolizable material occurs at the interface between the wick 37 and the heater 36 by supplying thermal energy to the aerosolizable material, causing evaporation, thus producing an aerosol. The wick 37 and the heater 36 may be collectively referred to as the vaporizer or atomizer 15.

[0091] Typically, there will be a single wick, but it is envisioned that there may be more than one wick, for example, two, three, four, or five wicks.

[0092] As noted above, the wick may be formed from a sintered material. The sintered material may include sintered ceramic, sintered metal fibers / powder, or a combination of the two. The sintered wick(s) (or at least one / all of them) may have an electric resistance heater deposited / embedded therein. Such a heater may be formed from a thermally conductive alloy, such as a NiCr alloy. Alternatively, the sintered material may have electrical properties such that the sintered material heats when an electric current is passed through it. Thus, the aerosol generation component and the wick may be considered to be integrated. In some embodiments, the aerosol generation component and the wick are formed from the same material and form a single component.

[0093] In some embodiments, the wick is formed from a sintered metal material and is generally in the form of a planar sheet. Thus, the wick element may have a substantially thin, flat shape. For example, it may be considered a sheet, layer, film, substrate, or the like. This means that the thickness of the wick is less than, or significantly less than, at least one of the length and width of the wick. Thus, the thickness of the wick (its smallest dimension) is less than, or significantly less than, its longest dimension.

[0094] The wick may be made of homogeneous, granular, fibrous, or flocculent sintered metal(s) to form a capillary structure. The wick element may be made of a conductive material that is a nonwoven, sintered porous web structure containing metal fibers, such as stainless steel fibers. For example, the stainless steel may be AISI (American Iron and Steel Institute) 316L (corresponding to European standard 1.4404). The weight of the material may be 100 to 300 g / m. 2 The range may be:

[0095] When the wick is generally planar, the wick thickness can range from 75 to 250 μm. A typical fiber diameter can be about 12 μm, and a typical average pore size (the size of the voids between the fibers) can be about 32 μm. An example of this type of material is Bekipor (RTM) ST porous metal fiber media, manufactured by NV Bekaert SA, Belgium, a range of porous nonwoven fiber matrix materials made by sintering stainless steel fibers.

[0096] It should also be noted that the material is described as planar, which refers to the relative dimensions of the sheet material and the wick (thickness being many times smaller than length and / or width), but does not necessarily indicate flatness, particularly the flatness of the final wick made from the material. The wick may be flat, but may alternatively be formed from the sheet material into a non-planar shape such as curved, undulating, corrugated, ribbed, formed into a tube, or otherwise made concave and / or convex.

[0097] The wick element can have a variety of characteristics. The wick element is formed from a porous material to enable the necessary wicking or capillary effect to draw the source liquid from the reservoir for the aerosolizable material (where the wick meets the aerosolizable material at the reservoir-contact site) through the wick element to the vaporization interface. Porosity is typically provided by a plurality of interconnected or partially interconnected pores (holes or gaps) throughout the aerosolizable material, opening toward the outer surface of the aerosolizable material. Any level of porosity can be used, depending on the material, pore size, and desired wicking rate. For example, a porosity of 30% to 85%, e.g., 40% to 70%, 50% to 80%, 35% to 75%, or 40% to 75% can be selected. Because the porosity may or may not be uniform throughout the wick, the porosity may be an average porosity value for the entire wick element. For example, the pore size at the reservoir-contact site may be different from the pore size closer to the heater.

[0098] It is useful for the wick to be sufficiently rigid to support itself in the article, for example, the wick may be attached at or near one or two edges and may be required to maintain its position without substantial bending, flexing, or sagging.

[0099] As an example, porous sintered ceramic is a useful material for use as a wick element. Any ceramic with suitable porosity can be used. When porous ceramic is selected as the porous wick material, the porous wick material is available as a powder that can be formed into a solid by sintering (heating to cause agglomeration, possibly under pressure). Sintering then solidifies the ceramic to create the porous wick.

[0100] Article 30 further includes a mouthpiece 35 having an opening through which a user can inhale the aerosol produced by vaporizer 15. The aerosol for inhalation may be described as an aerosol stream or an inhalable air stream.

[0101] The aerosol delivery device 20 includes a power source (a rechargeable cell or battery 14, hereafter referred to as the battery) for powering the e-cigarette 10, and a controller (printed circuit board (PCB)) 28 and / or other electronics for generally controlling the e-cigarette 10. Thus, the aerosol delivery device may also be considered a battery section, or a control unit or section.

[0102] During operation of the device, the controller determines that a user has initiated a request for aerosol generation. This may be done via a button on the device that sends a signal to the controller that the aerosol generator should be powered. Alternatively, a sensor located in or proximal to the airflow path can detect airflow through the airflow path and communicate this detection to the controller. Sensors may be present in addition to the presence of a button, as the sensor may be used to determine certain usage characteristics, such as airflow, timing of aerosol generation, etc.

[0103] For example, in use, when heater 36 receives power from battery 14, as controlled by circuit board 28, which may respond to pressure changes detected by an air pressure sensor (not shown), heater 36 vaporizes the aerosolizable material delivered by wick 37 to produce an aerosol, and this aerosol stream is then inhaled by the user through an opening in mouthpiece 35. The aerosol is transported from the aerosol source to mouthpiece 35 along an air channel (not shown in FIG. 1 ) connecting the aerosol source to the mouthpiece opening as the user inhales into the mouthpiece.

[0104] In this particular example, device 20 and article 30 are detachable from one another by separation in a direction parallel to the longitudinal axis, as shown in Figure 1, but when system 10 is in use, are coupled together by cooperating engaging elements 21, 31 (e.g., threaded, magnetic, or bayonet fittings) to form a mechanical and electrical connection between device 20 and article 30, particularly connecting heater 36 to battery 14. The battery may be charged as known to those skilled in the art.

[0105] As mentioned, the type of aerosol-generating component, such as a heating element, that may be utilized in the atomizing portion of an e-cigarette (the component configured to generate vapor from a liquid feedstock) combines the functions of heating and liquid delivery by being both electrically conductive (resistive) and porous. Note that the reference to being electrically conductive (resistive) refers to a component capable of generating heat in response to an electric current passing through it. Such a flow can be provided by so-called resistive or inductive heating. An example of a suitable material for this flow is an electrically conductive material, such as a metal or metal alloy, formed into a sheet-like shape, i.e., a planar shape having a thickness many times smaller than its length or width. Examples in this regard can be meshes, webs, grids, and the like. A mesh can be formed from metal wires or fibers woven together or alternatively aggregated into a nonwoven structure. For example, fibers can be aggregated by sintering, which applies heat and / or pressure to a collection of metal fibers to compress them into a single porous mass.

[0106] These structures can provide appropriately sized voids and gaps between the metal fibers to provide capillary forces for wicking liquids. Therefore, these structures can also be considered porous to allow for liquid uptake and distribution. Furthermore, air can penetrate the structure due to the voids and gaps between the metal fibers. Metals are also electrically conductive and therefore suitable for resistive heating, whereby electrical current flowing through a material with electrical resistance generates heat. However, this type of structure is not limited to metals; other conductive materials can be formed into fibers and mesh, lattice, or web structures. Examples include ceramic materials that may or may not be doped with substances intended to adjust the physical properties of the mesh.

[0107] This type of planar, sheet-like porous aerosol-generating component can be positioned within an electronic cigarette within an aerosol-generating chamber that forms part of the airflow channel. The aerosol-generating component can be oriented within the chamber so that airflow through the chamber flows in a surface direction, i.e., substantially parallel to the surface of the generally planar, sheet-like aerosol-generating component. Examples of such configurations can be found in WO 2010 / 045670 and WO 2010 / 045671, the contents of which are incorporated herein by reference in their entireties. The air then flows over the heating element and collects the vapor, thereby resulting in highly efficient aerosol generation. In an alternative example, the aerosol-generating component can be oriented within the chamber so that airflow through the chamber flows substantially transverse to the surface direction, i.e., substantially perpendicular to the surface of the generally planar, sheet-like aerosol-generating component. An example of such a configuration can be found in WO 2018 / 211252, the contents of which are incorporated herein by reference in their entireties.

[0108] The aerosol-generating component may have any one of the following structures: woven or woven fabric, mesh, fabric, open-pored fiber, open-pored sintered, open-pored foam, or open-pored deposition. These structures are particularly suitable for providing an aerosol-generating component with a high degree of porosity. A high degree of porosity can ensure that the heat generated by the aerosol-generating component is primarily used for evaporating the liquid, resulting in high efficiency. Porosities of more than 50% may be envisaged in these structures. In one embodiment, the porosity of the aerosol-generating component is 50% or more, 60% or more, or 70% or more. The open-pored fiber structure may, for example, consist of a nonwoven fabric, which may optionally be compressible and further sintered to improve cohesion. The open-pored sintered structure may, for example, consist of a granular, fibrous, or flocculent sintered composite produced by a film casting process. Open-pore deposition structures can be produced, for example, by CVD processes, PVD processes, or flame spraying. Open-pore foams are, in principle, commercially available and are also available in thin, microporous designs.

[0109] In one embodiment, the aerosol-generating component has at least two layers, and these layers comprise at least one of the following structures: plate, foil, paper, mesh, woven structure, fabric, open-pore fiber structure, open-pore sintered structure, open-pore foam, or open-pore stack structure. For example, the aerosol-generating component may be formed by an electric heating resistor consisting of a metal foil combined with a structure containing a capillary structure. When the aerosol-generating component is considered to be formed from a single layer, such a layer may be formed from a metal wire fabric or a nonwoven metal fiber fabric. The individual layers are advantageously, but not necessarily, connected to each other by a heat treatment such as sintering or welding. For example, the aerosol-generating component may be designed as a sintered composite consisting of a stainless steel foil and one or more layers of stainless steel wire fabric (materials such as AISI 304 or AISI 316). Alternatively, the aerosol-generating component may be designed as a sintered composite consisting of at least two layers of stainless steel wire fabric. These layers may be connected to each other by spot welding or resistance welding. The individual layers may also be mechanically connected to each other. For example, a double-layer wire fabric may be produced by simply folding a single layer. Instead of stainless steel, for example, a heating conductor alloy, particularly a NiCr alloy and a CrFeAl alloy ("Kanthal"), which have an even higher specific electrical resistivity than stainless steel, may be used. The material connection between the layers is achieved by heat treatment, so that the layers maintain contact with each other even under adverse conditions, for example, during heating by the aerosol-generating component and the resulting induced thermal expansion. Alternatively, the aerosol-generating component may be formed by sintering multiple individual fibers together. Thus, the aerosol-generating component may be composed of sintered fibers, for example, sintered metal fibers.

[0110] The aerosol-generating component may include a thin, electrically conductive layer of an electrically resistive material, such as platinum, nickel, molybdenum, tungsten, or tantalum, applied to the vaporizer surface by a PVD or CVD process or other suitable process. In this case, the aerosol-generating component may include an electrically insulating material, such as a ceramic electrically insulating material. Examples of suitable electrically resistive materials include stainless steels, such as AISI 304 or AISI 316, and heating conductor alloys, particularly NiCr alloys and CrFeAl alloys ("Kanthal"), such as DIN material numbers 2,4658, 2,4867, 2,4869, 2,4872, 1,4843, 1,4860, 1,4725, 1,4765, and 1,4767.

[0111] As previously described, the aerosol-generating component can be formed from a sintered metal fiber material, which can be in the form of a sheet. This type of material can be thought of as a mesh or irregular grid, created by sintering a randomly aligned configuration or array of spaced apart metal fibers or strands. A single fiber layer, or several layers, e.g., up to five layers, can be used. By way of example, the metal fibers may have a diameter of 8-12 μm, arranged to provide a sheet 0.16 mm thick, and weighing 100 g / m. 2 ~1500g / m 2 , e.g., 150 g / m 2 ~1000g / m 2 , 200g / m 2 ~500g / m 2 or 200-250g / m 2The fibers are spaced apart to provide a material density of 0.1 mm and a porosity of 84%. The sheet thickness can also range from 0.1 mm to 0.2 mm, e.g., 0.1 mm to 0.15 mm. Specific thicknesses include 0.10 mm, 0.11 mm, 0.12 mm, 0.13 mm, 0.14 mm, 0.15 mm, or 0.1 mm. Generally, the aerosol-generating component has a uniform thickness. However, it will be understood from the discussion below that the thickness of the aerosol-generating component can also vary. This may be due, for example, to portions of the aerosol-generating component being subjected to compression. Different fiber diameters and thicknesses can be selected to vary the porosity of the aerosol-generating component. For example, the aerosol-generating component can have a porosity of 66% or more, or 70% or more, or 75% or more, or 80% or more, or 85% or more, or 86% or more.

[0112] The aerosol-generating component may form a substantially planar structure including a first and second surface. The substantially planar structure may take the form of any two-dimensional shape, such as a circle, semicircle, triangle, square, rectangle, and / or polygon. Generally, the aerosol-generating component has a uniform thickness.

[0113] The width and / or length of the aerosol-generating component can be from about 1 mm to about 50 mm. For example, the width and / or length of the vaporizer can be from 1 mm, 2 mm, 3 mm, 4 mm, 5 mm, 6 mm, 7 mm, 8 mm, 9 mm, or 10 mm. The width can generally be less than the length of the aerosol-generating component.

[0114] If the aerosol-generating component is made of an electrically resistive material, passing an electric current through the aerosol-generating component can generate heat (so-called Joule heating). In this regard, the electrical resistance of the aerosol-generating component can be appropriately selected. For example, the aerosol-generating component can have an electrical resistance of 2 ohms or less, such as 1.8 ohms or less, such as 1.7 ohms or less, such as 1.6 ohms or less, such as 1.5 ohms or less, such as 1.4 ohms or less, such as 1.3 ohms or less, such as 1.2 ohms or less, such as 1.1 ohms or less, such as 1.0 ohms or less, such as 0.9 ohms or less, such as 0.8 ohms or less, such as 0.7 ohms or less, such as 0.6 ohms or less, such as 0.5 ohms or less. Parameters of the aerosol-generating component, such as its material, thickness, width, length, porosity, etc., can be selected to provide the desired resistance. In this regard, a relatively low resistance facilitates higher power draw from the power source, which can be advantageous for achieving high rates of aerosolization. On the other hand, the resistance should not be so low as to compromise the integrity of the aerosol generator, for example, the resistance should not be less than 0.5 ohms.

[0115] Planar aerosol-generating components, such as heating elements, suitable for use in the systems, devices, and articles disclosed herein can be formed by stamping or cutting (such as laser cutting) the required shape from a larger sheet of porous material. This can involve stamping, cutting, or otherwise removing material to create openings in the aerosol-generating component. These openings can affect both the ability of air to pass through the aerosol-generating component and the tendency for electrical current to flow through certain areas.

[0116] As previously described, in one aspect, the present invention relates to a delivery system comprising a powered aerosol generating device and an aerosolizable material, wherein the aerosolizable material comprises at least one carboxylated active, and the system is configured to effect selective decarboxylation of the carboxylated active. In particular, the aerosol generating device comprises a power source, such as an electrical power source, a controller, and at least one aerosol generator (e.g., heater) configured to aerosolize (heat) the aerosolizable material to form an inhalable aerosol, and the controller is configured to facilitate delivery of power to the aerosol generator (heater) at more than one power level.

[0117] More specifically, article 30 contains an aerosolizable material disposed within first reservoir 38. The aerosolizable material contains at least one active, such as a cannabinoid, in a carboxylated form, such as CBDA. After activation of the device, either by a button or a puff sensor (not shown), power is delivered to heater 36 to form an aerosol. When controlled to do so by the user, controller 28 delivers power to heater 36 at an "escalated" power profile. This increased power level causes the CBDA present in the aerosolizable material to be progressively decarboxylated in situ as it is vaporized. The resulting aerosol therefore contains decarboxylated CBD derived from CBDA, as well as other cannabinoids aerosolized during the heating process (such as decarboxylated cannabinoids already present in the aerosolizable material).

[0118] 2 and 2A, which illustrate schematic diagrams of a portion of an airflow channel through an aerosol delivery system described herein. In particular, FIGS. 2 and 2A refer to another embodiment of the invention in which a first aerosolizable material and a second aerosolizable material are stored at different locations within the system, and a heater 136 is shown disposed in airflow channel 100. Heater 136 is supplied with the first aerosolizable material in the manner described herein (e.g., via a wick (not shown)). During use, power is delivered from the device's power supply to heater 136, causing an aerosol to form from the first aerosolizable material. This first aerosol travels downstream within channel 100 until it impacts substrate 200, which may be formed from a capillary material such as cotton, cellulose acetate, or some other porous material. Substrate 200 is loaded with a second aerosolizable material comprising at least one active (such as a cannabinoid) in a carboxylated form (XA-, where X is associated with the active and A is associated with the carboxyl group of the active). Substrate 200 completely spans airflow channel 100, but due to its porous nature, the first aerosol can pass through substrate 200, so that heat from the first aerosol promotes decarboxylation of XA to form a second aerosol comprising the decarboxylated form of the active, e.g., a cannabinoid (shown as X in FIG. 2). Substrate 200 is positioned a distance D from heater 136. This distance D can be varied to change the impact temperature of the aerosol when it impacts the substrate. This variation can be achieved by using substrate 200 in removable segments 210 (shown in FIG. 2A) that can be positioned at various points within the airflow channel as desired by the user. The removable segment 210 will typically include a downstream end 205, where the substrate 200 is generally located, and an upstream end 206, which forms a mouthpiece for the user. The substrate 200 may be replaceable within the removable segment 210 to facilitate replacing the substrate 200 from time to time.The removable segment 210 may be slightly tapered to facilitate an interference fit when inserted into the channel 100 .

[0119] 3 refers to another embodiment in which the substrate 200 does not completely span the airflow channel 100. This configuration may be achieved by providing a segmented region within the downstream end 205 of the removable segment 210 such that the first aerosol passes through all of the segments, but only a portion of the segments include the substrate 200. Such an approach essentially attenuates the interaction between the first aerosol and the substrate, resulting in a second aerosol with relatively reduced levels of decarboxylated actives, such as cannabinoids.

[0120] FIG. 4 refers to another embodiment of the invention in which a first aerosolizable material and a second aerosolizable material are stored at different locations within the system. In particular, a portion of an aerosol delivery system is shown schematically, in which a first reservoir 310 and a second reservoir 320 are located. The first reservoir 310 contains a first aerosolizable material A1, and the second reservoir 320 contains a second aerosolizable material A2. The first and second reservoirs are fluidly connected. In this particular example, a membrane 330 separates the two reservoirs, although a pump or other means for fluid transfer between the two reservoirs may also be provided. The second reservoir 320 may contain one or more heaters 336, 337. The heater 336 is internal. The heater 337 is external. Both may also be provided. Each heater is connected to the device's power supply (not shown) and controlled as described herein. Briefly, when controlled to do so by a user, heater 336 and / or heater 337 are powered by a power source, so that they heat aerosolizable material A2 to an elevated temperature, as described herein. It should be understood that additional heaters may also be provided. Due to the elevated temperature, carboxylated cannabinoids within aerosolizable material A2 will be decarboxylated. Over time, aerosolizable material A2 becomes increasingly concentrated with the decarboxylated active (such as a decarboxylated cannabinoid), which may then be provided to a first reservoir for aerosolization by an aerosol generator (e.g., a heater (not shown)) to form an inhalable aerosol. The cannabinoids present in each reservoir may be the same or different (independent of their carboxylation state) and may be any of the cannabinoids described herein. For example, the cannabinoid present in the first reservoir may be CBD and the cannabinoid present in the second reservoir may be CBDA. Alternatively, the cannabinoid present in the first reservoir may be THC and the cannabinoid present in the second reservoir may be CBDA. [Example]

[0121] Example 1 A study was conducted to investigate the decarboxylation of CBDA to CBD in e-aerosol during vaping. E-liquid samples containing 4.5% CBDA were formulated.

[0122] Aerosol was then generated from this e-liquid using an "ePod" (available at https: / / www.vuse.com / gb / en / e-cigarette-devices / epod-devices).

[0123] CBD measurements were performed on e-liquids and e-aerosols to measure changes in CBD levels before and after vaping. Measurements of CBD before and after aerosolization were performed using a quantitative method based on liquid chromatography coupled with an ultraviolet diode array detector.

[0124] Materials and Equipment Table 1 shows the unique identifiers of the materials and equipment used, including the cannabinoid standards:

[0125] [Table 1]

[0126] Preparation of e-liquid 10.4 g of 4.5% CBDA e-liquid was prepared (propylene glycol, 7.0250 g; glycerol, 2.9468 g; CBDA, 0.4659 g). The e-liquid was stored in a scintillation vial covered with tin foil to block light. The e-liquid was then vortex mixed and stored in a cool, dry environment overnight, allowing the e-liquid to homogenize and prepare for aerosolization.

[0127] Aerosol Analysis Sampling of the formulated e-liquid began the day after the initial sample was prepared. The e-liquid was divided among three ePod cartomizers (1.2 mL each). After filling, the cartomizers were allowed to stand for 1 hour while stored away from light. Aerosol generation was performed on a Borgwaldt 20-port puffing engine LM20e. Fully charged devices and their respective cartomizers (pre-weighed) were connected to pad holders containing pre-weighed Cambridge filter pads (CFPs) at a 15-degree device angle.

[0128] Aerosol generation utilized the CRM81 puffing method (55 mL, 3-second puff duration with 30-second puff intervals). Four puff blocks of 20 puffs each were performed. Each of these puff blocks was collected on the same pad. Device mass loss (DML) was measured between each puff block to estimate the trajectory of ACM generation. Rather than 80 consecutive puffs, an approximately 4-minute interval was allowed between puff blocks to prototype and generate a more representative vaping sample.

[0129] Finally, after completing all puff blocks, the device and pad holder were weighed to calculate the aerosol recovered mass (ACM) and device mass loss (DML), as shown in Table 2. Note that between puff blocks, the pad holder was not weighed, only the device.

[0130] [Table 2]

[0131] After aerosol generation and collection, the CFPs were removed from the pad holder, folded in half, and the side of the pad holder facing away from the device was used to wipe the inside of the pad holder. They were then transferred to Erlenmeyer flasks, and 20 mL of methanol was added to each flask. This was done to achieve a CBD concentration of approximately 1 mg / mL, assuming 100% decarboxylation. The flasks were covered with foil to block light and shaken at 150 rpm for 45 minutes.

[0132] After shaking, the solution extract was syringe filtered (Merck Millipore Milex-GV PVDF 0.22 μm filter) into an LC vial. The 1 mg / mL target was reached with the dilution of the extract solution in ACM, so no further dilution was necessary. The solution was crimped, vortex mixed for 5 seconds, and then loaded into the instrument. Every effort was made to reduce light exposure to the pad extract while vialing the sample for HPLC-UVDAD injection. The flask was wrapped in foil at all possible points.

[0133] E-Liquid Analysis Three replicates of CBDA formulations were generated. 220 μL of e-liquid was volumetrically dispensed and measured in triplicate. The e-liquid was then diluted with 10 mL of methanol and thoroughly mixed by gentle inversion, followed by vortex mixing for 5 seconds. The samples were then syringe filtered (Merck Millipore Milex-GV PVDF 0.22 μm filter) into LC vials, crimped, and vortex mixed for 5 seconds. These samples were then loaded into the instrument for injection on the same day.

[0134] To demonstrate the accuracy of this method, one replicate of diluted e-liquid and one replicate of diluted aerosol were fortified with known concentrations of CBD, as shown in Table 3.

[0135] [Table 3]

[0136] HPPL-UVDAD analysis All calibration standards, calibration check standards, blanks, test samples, and fortified samples were analyzed by HPLC-UVDAD using an Agilent 1260 liquid chromatograph with an autosampler, column oven, and UV analysis by diode array detector (DAD), and a 1260 binary pump.

[0137] One individual sequence was run. Freshly prepared mobile phase was used to flush the LC lines before the start of the run. After flushing the lines, the mobile phase was switched through the column, which was left to purge for 1 hour before the injection began. Agilent OpenLab CDS ChemStation Edition was used to run the sequence and process the data. All chromatograms were reviewed for retention time, peak shape, and the software confirmed suitable peak integration.

[0138] result Six calibration standards spanning the range of 0.05 to 2 mg / mL of CBD were injected as part of the sequence (shown in Table 4).

[0139] [Table 4]

[0140] The precision of this calibration curve was monitored throughout the run by injection of calibration check standards and fortified samples. The calibration curve demonstrated good precision throughout the run (see Table 5). Furthermore, good precision is observed with the fortified e-aerosol.

[0141] [Table 5]

[0142] Generating quantitative results was not possible for the fortified e-liquids because the original CBD amount in the unfortified e-liquids was below the LOQ (limit of quantification).

[0143] The measured levels (mg / g) of CBD in e-liquids are shown in Table 6.1.

[0144] [Table 6] The measured levels of CBD in the aerosol replicates are shown in Table 6.2 (mg CBD per gram of e-liquid).

[0145] [Table 7]

[0146] The results presented in Table 6.1 show that the level of CBD before aerosolization was below the LOQ. Therefore, the CBD seen in the aerosol must be due to the aerosolization process. To estimate the percentage of decarboxylation, the following calculations are required: First, the concentration of CBDA in the e-liquid is known since the e-liquid was formulated in the laboratory. This concentration was used to calculate the concentration of CBD, assuming 100% decarboxylation. The ratio of these compounds (CBDA and CBD) was required because of the different molecular weights of the compounds.

[0147] Equation 1 Ratio of CBD to CBDA = (314.469 gmol -1 ÷358.478gmol -1 )=0.877

[0148] This ratio and the initial CBDA concentration were used to calculate the expected concentration of CBD (assuming 100% decarboxylation). This expected concentration also assumes that the CBDA used in formulation is 100% pure and that there is no chemical or physical loss of CBDA from the e-liquid between formulation and e-aerosol collection.

[0149]

number

[0150] The determined decarboxylations are shown in Table 7.

[0151] [Table 8]

[0152] These results indicate that the initial CBD levels in CBDA e-liquids are below the limit of quantification. After aerosolization, quantifiable CBD levels are present. Therefore, decarboxylation of CBDA to CBD is present in the vaping systems tested.

[0153] Example 2 Further tests were carried out to investigate the effect of different conditions of use on the conversion process.

[0154] The e-liquid used in this example contained 5.61% w / w CBDA (the remainder of the formulation included 70% w / w propylene glycol and 24.39% w / w glycerol).

[0155] The study device was a commercially available e-cigarette device (Kangertech Evod variable voltage (VV) 1300mAh with Kanger EVOD clearomizer + MT32 synthetic silica wick 1.8Ω coil).

[0156] The device is button operated, and voltage / power is varied by rotating the base of the device. This device was used because it allows both power and puff duration to be varied within the boundaries of traditional vaping behavior. All tanks were maintained at a minimum volume of 50% of the maximum liquid level to be consistent across experiments. Airflow through the device was fixed.

[0157] Power Fluctuation: 5W 8W 12W Puffing fluctuation: Low - 55mL puff volume, 3 second puff duration Medium - 55mL puff volume, 4 second puff duration High - 55mL puff volume, 5 second puff duration

[0158] Analysis of CBDA and CBD was performed using an LC-DAD-MS approach (Agilent 1260 liquid chromatograph with autosampler, column oven, UV analysis with diode array detector (DAD), quaternary pump (600 bar); Varian / Agilent MS500 ion trap equipped with electrospray ion source). The stationary phase used was Agilent SB C18 4.6 x 100 with a particle size of 1.7 microns.

[0159] Reference compounds were obtained from Sigma Aldrich. Samples were diluted with a 1:1 acetone / ethanol mixture based on the initial concentration to reach a final CBD / CBDA concentration of approximately 100 micrograms / mL.

[0160] To detect cannabinoids, the DAD detector was set to 280 nm, and spectra were collected in the range of 200–400 nm. Mass spectra were acquired in positive ion mode (for analysis of neutral cannabinoids) and negative ion mode (for analysis of the acidic forms). Calibration curves were obtained by plotting area (280 nm) versus concentration (µg / mL) over the range of 500–5 µg / mL. The detection limit by the DAD at 280 nm is 0.5 micrograms / mL. Mass spectrometry was used to confirm the structure of detected compounds and to analyze smaller amounts of trace compounds. Calibration curves were also obtained for the mass spectrometry plot area of ​​ion species ([M+H]+ for the neutral form and [MH]- for the acidic form) versus concentration.

[0161] Reference standard used for quantification of CBDA and CBD (product code = PHL85705 https: / / www.sigmaaldrich.com / GB / en / product / supelco / phl85705) and CBDA (product code = 39961 https: / / www.sigmaaldrich.com / GB / en / product / sial / 39961).

[0162] The results of the evaluation of power and puffing variability are shown in Table 8:

[0163] [Table 9] TIFF0007742479000013.tif223149

[0164] It is clear that increasing the power increases the amount of CBD in the aerosol. In particular, the relative percentage of CBD (compared to CBDA) in the aerosol is generally higher at higher power settings. Furthermore, longer puffs generally also result in an increase in the relative percentage of CBD (compared to CBDA) in the aerosol.

[0165] Example 3 A further example was carried out in the same manner as Example 2, but using a formulation that also contained water (CBDA 5.61% w / w, propylene glycol 70% w / w, glycerol 21.39% w / w, water 3% w / w). The results of this example are shown in Table 9.

[0166] As can be seen, at lower powers, the addition of water to the formulation resulted in an increased relative percentage of CBD (compared to CBDA) compared to formulations without water present. Thus, using a formulation that includes water allows for a higher CBD percentage in the aerosol at lower powers.

[0167] [Table 10]

[0168] The various embodiments described herein are presented solely to aid in the understanding and teaching of the claimed features. These embodiments are provided only as a representative sample of embodiments and are not intended to be exhaustive and / or exclusive. It is understood that the advantages, embodiments, examples, functions, features, structures, and / or other aspects described herein should not be considered limitations on the scope of the invention as defined by the claims or equivalents thereof, and that other embodiments may be utilized and modifications may be made without departing from the scope of the invention as claimed. Various embodiments of the invention may suitably comprise, consist of, or consist essentially of any suitable combination of the disclosed elements, components, features, parts, steps, means, etc., other than those specifically described herein. Furthermore, this disclosure may include other inventions not claimed herein but which may be claimed in the future.

Claims

1. A delivery system comprising a powered aerosol generating device and an aerosolizable material, wherein the powered aerosol generating device comprises a power source and a controller, the system comprising a first aerosolizable material and a second aerosolizable material, the second aerosolizable material comprising at least one carboxylated active and stored in the system separately from the first aerosolizable material; the second aerosolizable material is stored in a second reservoir separate from the first reservoir in which the first aerosolizable material is disposed; one or more heaters configured to selectively heat the second aerosolizable material in the second reservoir; A delivery system wherein the first aerosolizable material and / or the second aerosolizable material are liquids.

2. 2. The delivery system of claim 1, wherein the one or more heaters are selected from one or more internal heaters in contact with the second aerosolizable material and / or one or more external heaters not in contact with the second aerosolizable material.

3. 10. The delivery system of claim 1, wherein the one or more heaters are configured to heat the second aerosolizable material to a temperature above ambient but below a temperature at which significant vaporization of the second aerosolizable material can occur.

4. 3. The delivery system of claim 2, wherein the one or more heaters are configured to heat the second aerosolizable material to a temperature above ambient but below a temperature at which significant vaporization of the second aerosolizable material can occur.

5. 5. The delivery system of claim 4, wherein the temperature to which the second aerosolizable material is heated is between 50°C and 150°C.

6. The delivery system of claim 5 , wherein the second aerosolizable material is heated for a sustained period of time.

7. A delivery system according to any preceding claim, wherein the first and second reservoirs are in fluid communication.

8. 8. The delivery system of claim 7, wherein a user can control the extent to which transfer of the second aerosolizable material into the first reservoir occurs.

9. 10. The delivery system of claim 8, wherein the pump controls the transfer of a specific amount of the second aerosolizable material when controlled to do so by the user.

10. 10. The delivery system of claim 8, wherein a button, switch, touchpad, or the like is used to control the transfer of the second aerosolizable material to the first reservoir.

11. 10. The delivery system of claim 8, wherein the controller is configured to initiate the transfer of a specific amount of the second aerosolizable material to the first reservoir according to a specific schedule.

12. 7. The delivery system of claim 1, wherein the system comprises an aerosol generator, such as a heater, configured to convert the first aerosolizable material into an aerosol.

13. 13. The delivery system of claim 12, wherein the second aerosolizable material is disposed on a substrate disposed within the system such that, during use, aerosol from the first aerosolizable material contacts the substrate.

14. The delivery system of claim 13 , wherein the substrate is a porous substrate.

15. 7. The delivery system of any one of claims 1 to 6, wherein the at least one carboxylated active is a cannabinoid, such as cannabidiolic acid (CBDA).

16. 7. The delivery system of any one of claims 1 to 6, wherein the second aerosolizable material comprises one or more additional actives, such as a cannabinoid, and wherein the one or more additional actives are in a decarboxylated form when in the aerosolizable material.

17. 17. The delivery system of claim 16, wherein the one or more additional actives in decarboxylated form is cannabidiol (CBD).

18. A delivery system as described in claim 16, wherein the ratio of at least one active agent present in a carboxylated form to one or more additional active agents in a decarboxylated form is from 99:1 to 1:

99.

19. 17. The delivery system of claim 16, wherein the first aerosolizable material comprises the one or more actives in a decarboxylated form when in the first aerosolizable material.

20. The delivery system of any one of claims 1 to 6, wherein the aerosolizable material further comprises a carrier component and optionally one or more flavorings.

21. 21. The delivery system of claim 20, wherein the carrier component comprises one or more of propylene glycol and glycerol.

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