Guidewire

Abstract

To provide a guide wire in which setting of flexibility of a coil body is easy.SOLUTION: There is provided a guide wire including at least one strand forming a coil body. The at least one strand includes at least one groove.SELECTED DRAWING: Figure 2

Description

[Technical Field]

[0001] The present disclosure relates to guidewires. [Background technology]

[0002] BACKGROUND ART Guidewires having a coil body are known (see, for example, Patent Documents 1 and 2). Guidewires are inserted into body cavities such as blood vessels to assist the insertion of medical devices such as catheters and stents. [Prior art documents] [Patent documents]

[0003] [Patent Document 1] Japanese Patent Application Laid-Open No. 2004-230142 [Patent Document 2] International Publication No. 2021 / 117657 Summary of the Invention [Problem to be solved by the invention]

[0004] It is not easy to properly set the flexibility of the coil body while ensuring its pushability.

[0005] Therefore, an object of the present disclosure is to provide a guidewire in which the flexibility of the coil body can be easily set. [Means for solving the problem]

[0006] In one aspect of the present disclosure, the guidewire has at least one wire forming a coil body, and the at least one wire has at least one groove.

[0007] In one embodiment of the present disclosure, the guidewire is a guidewire in which the at least one groove is provided only in the distal end portion of the guidewire.

[0008] In one embodiment of the present disclosure, the guidewire is such that the at least one groove has a pitch that decreases from the proximal end to the distal end of the guidewire.

[0009] In one embodiment of the present disclosure, the guidewire is a guidewire in which the width or depth of the at least one groove increases from the proximal end side to the distal end side of the guidewire.

[0010] In one embodiment of the present disclosure, the guidewire is a guidewire in which the at least one strand forms a contrast marker.

[0011] In one embodiment of the present disclosure, the guidewire is a guidewire in which the at least one wire forms a distal end portion of the guidewire or a portion extending from the distal end portion to the proximal end portion of the guidewire.

[0012] In one embodiment of the present disclosure, the guidewire is a guidewire in which the at least one groove is provided in a portion of the at least one wire that extends over the entire circumference of the guidewire.

[0013] In one embodiment of the present disclosure, the guidewire is a guidewire in which the at least one groove is not provided in a portion of the at least one wire aligned in a first direction perpendicular to the axial direction of the guidewire, but is provided in a portion of the at least one wire aligned in a second direction perpendicular to both the axial direction of the guidewire and the first direction.

[0014] In one embodiment of the present disclosure, the guidewire is a guidewire in which the at least one groove is provided on both surfaces or only one surface in the second direction of the at least one strand itself.

[0015] In one embodiment of the present disclosure, the guidewire is a guidewire in which the at least one groove is provided on both sides or only one side of the at least one strand itself in the axial direction of the guidewire.

[0016] In one embodiment of the present disclosure, the guidewire is a guidewire in which the at least one groove extends in the axial direction of the guidewire.

[0017] As one embodiment of the present disclosure, the guidewire is a guidewire in which the at least one groove is provided only in a portion of the at least one wire that is located radially outward of the guidewire.

[0018] In one embodiment of the present disclosure, the guidewire is a guidewire in which the at least one groove is provided in a spiral or annular shape on the outer circumferential surface of the at least one strand itself.

[0019] As one embodiment of the present disclosure, a method for manufacturing a guidewire includes an irradiation step of forming the at least one groove by irradiating laser light onto the at least one wire in a state in which the coil body is formed. [Effects of the Invention]

[0020] According to the present disclosure, a guidewire can be provided in which the flexibility of the coil body can be easily set. [Brief explanation of the drawings]

[0021] [Figure 1] 1 is a partially cross-sectional side view showing a guidewire according to a first embodiment. [Figure 2] FIG. 2 is an enlarged view of a portion of FIG. [Figure 3] 3 is a cross-sectional view taken along the line AA in FIG. 2. [Figure 4] 1. FIG. 4 is a side view showing a modified example of the coil body shown in FIG. [Figure 5] 1. FIG. 4 is a side view showing a modified example of the coil body shown in FIG. [Figure 6] 1. FIG. 4 is a side view showing a modified example of the coil body shown in FIG. [Figure 7] 1. FIG. 4 is a side view showing a modified example of the coil body shown in FIG. [Figure 8]FIG. 10 is a partial cross-sectional side view showing a guidewire according to a second embodiment. [Figure 9] FIG. 10 is a partial cross-sectional side view showing a guidewire according to a third embodiment. [Figure 10] FIG. 10 is a partial cross-sectional side view showing a guidewire according to a fourth embodiment. DETAILED DESCRIPTION OF THE INVENTION

[0022] Hereinafter, embodiments of the present disclosure will be described in detail with reference to the drawings.

[0023] As shown in FIGS. 1 and 2 , a guidewire 1 according to a first embodiment of the present disclosure has a core portion 8, a coil portion 7, a fixing portion 9, and a covering portion 10. The core portion 8 has a first core 8a and a second core 8b. The coil portion 7 has a coil body 2 (hereinafter also referred to as the first coil body 2) and another coil body (hereinafter also referred to as the second coil body 6). The fixing portion 9 has a first fixing material 9a, a second fixing material 9b, and a third fixing material 9c. The covering portion 10 has a first covering layer 10a, a second covering layer 10b, a third covering layer 10c, and a fourth covering layer 10d. The guidewire 1 according to this embodiment is suitable for, for example, percutaneous coronary intervention (PCI).

[0024] Hereinafter, the end located at the front when the guidewire 1 is introduced into a body cavity such as a blood vessel will be referred to as the tip end, and the opposite end will be referred to as the base end, and the direction along the axis O extending longitudinally along the center of the guidewire 1 will be referred to as the axial direction, the direction along a straight line perpendicular to the axis O will be referred to as the radial direction, and the direction circumferentially around the axis O will be referred to as the circumferential direction. Note that the drawings show the radial dimensions enlarged to make the structure easier to understand.

[0025] The first core 8a is linear and extends axially around the axis O, and is made of a metal material such as a superelastic alloy, such as a nickel (Ni)-titanium (Ti) alloy. The radial dimension of the first core 8a decreases from the base end toward the tip end. The cross-sectional shape of the first core 8a (the shape in a cross section perpendicular to the axial direction) is circular over the entire length of the first core 8a. The base end surface 8c of the first core 8a is joined to the tip surface of the second core 8b by welding.

[0026] The second core 8b is made of a metal material such as stainless steel and has a linear shape extending in the axial direction centered on the axis O. The cross-sectional shape of the second core 8b is circular over the entire length of the second core 8b.

[0027] The first coil body 2 is formed in a spiral shape with at least one wire 3 as the center, centered on the axis O. Specifically, the first coil body 2 is formed in a spiral shape with one wire 3. The first coil body 2 forms a radiopaque marker. That is, the first coil body 2 is formed from a material such as a metal containing a material with low X-ray transparency such as Pt or Au. The first coil body 2 is configured as a marker with radiopaque properties. The cross-sectional shape of the wire 3 itself that forms the first coil body 2 (the shape of a cross section perpendicular to the longitudinal direction of the wire 3 itself) is circular. The first coil body 2 forms only the tip portion 1a of the guidewire 1.

[0028] The second coil body 6 is provided closer to the base end than the first coil body 2. The second coil body 6 is formed from a single wire 3 and is spirally shaped about the axis O. The second coil body 6 is formed from a metal material such as stainless steel. The wire 3 that forms the second coil body 6 has a circular cross-sectional shape.

[0029] The outer diameter of the wires 3 themselves of the first coil body 2 is larger than the outer diameter of the wires 3 themselves of the second coil body 6. This improves the X-ray contrast of the first coil body 2, allowing the operator to clearly recognize the position of the tip portion 1a of the guidewire 1.

[0030] The first coil body 2 and the second coil body 6 each cover the first core 8a from the radial outside. The inner diameter of the first coil body 2 is larger than the outer diameter of the portion of the first core 8a located inside the first coil body 2. The inner diameter of the second coil body 6 is larger than the outer diameter of the portion of the first core 8a located inside the second coil body 6. The first coil body 2 and the second coil body 6 have approximately the same outer diameter. In other words, the coil portion 7 has an approximately uniform outer diameter in the axial direction.

[0031] The tip end of the first coil body 2 is fixed to the first core 8a by a first fixing material 9a. The base end of the first coil body 2 is fixed to the first core 8a by a second fixing material 9b. The tip end of the second coil body 6 is fixed to the first core 8a by the second fixing material 9b. The base end of the second coil body 6 is fixed to the first core 8a by a third fixing material 9c. The first fixing material 9a, the second fixing material 9b, and the third fixing material 9c are each a brazing material such as solder.

[0032] The first coating layer 10a coats the entire first coil body 2, the second coil body 6, the first fixing material 9a, the second fixing material 9b, and the third fixing material 9c. The second coating layer 10b coats the portion of the first core 8a closer to the base end than the third fixing material 9c, excluding the base end. The third coating layer 10c coats the joint between the first core 8a and the second core 8b. The fourth coating layer 10d coats the portion of the second core 8b excluding the tip and base ends.

[0033] The first coating layer 10a is made of, for example, a hydrophilic polymer, the second coating layer 10b and the fourth coating layer 10d are made of, for example, a fluorine-based resin, and the third coating layer 10c is made of, for example, a silicone resin.

[0034] As shown in FIGS. 2 and 3, at least one wire 3 forming the first coil body 2 has at least one spiral groove 4. Specifically, the outer peripheral surface of the wire 3 forming the first coil body 2 itself has a double spiral groove 4 formed by two grooves 4. Therefore, the first coil body 2 has a groove portion 5 formed by two grooves 4. Each groove 4 extends spirally along the axial direction (longitudinal direction) of the wire 3 itself. Each groove 4 has two opposing side surfaces 4a and a bottom surface 4b connecting these side surfaces 4a. The first coating layer 10a penetrates into each groove 4, resulting in good adhesion to the first coil body 2.

[0035] Each groove 4 has a constant width W (the distance between both side surfaces 4a) and a constant depth D (the depth D of the bottom surface 4b). The groove portions 5 form a predetermined pattern in which parts of the grooves 4 are arranged at a predetermined pitch P in the width direction of the groove 4. The pitch P of the groove portions 5 is constant.

[0036] Each groove 4 is provided over the entire axial length of the wire 3. Therefore, the groove portions 5 are provided over the entire circumference of the first coil body 2 with the axis O as the center.

[0037] There is no particular limitation on the method for forming each groove 4. For example, each groove 4 can be formed by cutting the outer circumferential surface of the wire 3 itself using a laser or the like irradiated perpendicular to the axial direction while rotating the wire 3 itself in a linearly stretched state before being coiled and feeding it in the axial direction.

[0038] The outer peripheral surface of the wire 3 that forms the second coil body 6 does not have the grooves 4. In other words, the grooves 4 are provided only in the first coil body 2. Therefore, the grooves 4 are provided only in the distal end portion 1a of the guidewire 1.

[0039] According to this embodiment, the provision of the groove portion 5 can increase flexibility while ensuring the X-ray contrast of the first coil body 2. Furthermore, by appropriately setting the width W, depth D, and pitch P of the grooves 4 of the groove portion 5, the flexibility of the distal end portion 1a of the guidewire 1 can be easily set.

[0040] The first coil body 2 and the second coil body 6 may each have a spiral shape other than a single spiral, for example, a double spiral or a triple or more spiral. The cross-sectional shape of the wires 3 themselves forming the first coil body 2 may be other than circular, for example, an ellipse, a rectangle, a square, a polygon, etc. The cross-sectional shape of the wires 3 themselves forming the second coil body 6 may be other than circular, for example, an ellipse, a rectangle, a square, a polygon, etc. The first coil body 2 is not limited to a contrast marker.

[0041] The cross-sectional shapes of the first core 8a and the second core 8b may be other than circular, and may be, for example, elliptical, rectangular, square, polygonal, etc. The cross-sectional shapes of the first core 8a and the second core 8b may vary in the axial direction. Furthermore, the configuration is not limited to joining the base end surface 8c of the first core 8a to the tip end surface of the second core 8b by welding. For example, the base end of the first core 8a and the tip end of the second core 8b may be positioned inside a tubular body and joined together. The core unit 8 is not limited to a configuration having the first core 8a and the second core 8b joined together. The first core 8a and the second core 8b may be integrally formed from the same material.

[0042] The first coating layer 10a, the second coating layer 10b, the third coating layer 10c, and the fourth coating layer 10d may each have a single-layer structure or a laminated structure. The coating portion 10 is not limited to a structure divided into the first coating layer 10a, the second coating layer 10b, the third coating layer 10c, and the fourth coating layer 10d in the axial direction.

[0043] The fixing portion 9 is not limited to a configuration having the first fixing member 9a, the second fixing member 9b, and the third fixing member 9c. For example, the base end of the first coil body 2 and the tip end of the second coil body 6 may be joined to each other without providing the second fixing member 9b.

[0044] The outer peripheral surface of the wires 3 that form the first coil body 2 may have grooves 4 in a spiral shape other than a double spiral, for example, a single spiral groove 4, or a triple or more multiple spiral groove 4. When the first coil body 2 is configured to be formed from two or more wires 3, it is possible for only some of the wires 3 that form the first coil body 2 to have at least one groove 4, rather than each of the wires 3. Groove portions 5 may be provided not only in the first coil body 2 but also in the second coil body 6.

[0045] Each groove 4 forming the groove portion 5 may be provided in an annular shape rather than a spiral shape. For example, as in a modified example shown in Fig. 4, the outer peripheral surface of the wire 3 forming the first coil body 2 may have a plurality of annular grooves 4 arranged at a predetermined pitch P in the axial direction of the wire 3 itself. In Fig. 4, only one groove 4 is marked with a reference symbol.

[0046] Each groove 4 forming the groove portion 5 may be formed in a shape other than a spiral or annular shape. For example, as in the modified example shown in FIG. 5 , each groove 4 forming the groove portion 5 may extend along the axial direction of the guidewire 1 (the direction along the axis O). In this case, each groove 4 may be formed only in a portion of the first coil body 2 located radially outward of the guidewire 1 (the radially outward of the axis O). In FIG. 5 , only one groove 4 is denoted by a reference symbol. With this configuration, the groove portion 5 can be easily formed by an irradiation step in which at least one groove 4 is formed by irradiating the first coil body 2 (at least one strand 3 in the state in which the first coil body 2 is formed) with laser light. Note that the irradiation step may be performed with the first coating layer 10a formed. In this case, the wavelength of the laser light is set to a wavelength at which the first coil body 2, which is made of metal or the like, easily absorbs heat, but the first coating layer 10a, which is made of nonmetal or the like, does not easily absorb heat.

[0047] Each groove 4 forming the groove portion 5 may extend in the axial direction of the guidewire 1 or in another direction. Each groove 4 forming the groove portion 5 may be provided in a portion of the first coil body 2 located radially inside the guidewire 1, in addition to or instead of a portion of the first coil body 2 located radially outside the guidewire 1. The groove portion 5 may be provided on one or both sides of at least one of the wires 3 itself in the axial direction of the guidewire 1.

[0048] Instead of being provided in a portion of the first coil body 2 that extends over the entire circumference of the guidewire 1, the groove portion 5 may be provided not in a portion of the first coil body 2 that is aligned in a first direction (the up-and-down direction in FIG. 6 or 7) that is perpendicular to the axial direction of the guidewire 1, but in a portion of the first coil body 2 that is aligned in a second direction (the direction perpendicular to the plane of the paper in FIG. 6 or 7) that is perpendicular to both the axial direction and the first direction of the guidewire 1, as in the modified example shown in FIG. 6 or 7. Only one groove 4 is denoted by a reference symbol in FIG. 6 or 7. With this configuration, it is possible to increase flexibility in a specific direction while ensuring the pushability of the first coil body 2.

[0049] The groove portions 5 provided in the portions of the first coil body 2 aligned in the second direction may be provided only on both sides of at least one wire 3 in the axial direction of the guidewire 1, as in the modified example shown in Fig. 6, for example. Alternatively, the groove portions 5 provided in the portions of the first coil body 2 aligned in the second direction may be provided only on one side of at least one wire 3 in the axial direction of the guidewire 1. With this configuration, the pushability of the first coil body 2 can be ensured while the flexibility in the first direction can be increased.

[0050] The groove portions 5 provided in the portions of the first coil body 2 aligned in the second direction may be provided on only both or only one side in the second direction of at least one of the wires 3 itself, as in the modified example shown in Fig. 7. With this configuration, it is possible to increase the flexibility of the first coil body 2 in the second direction while ensuring the pushability thereof.

[0051] The groove portion 5 is not limited to a configuration in which the width W, depth D, and pitch P of the grooves 4 are all constant. For example, the groove portion 5 may be configured so that the pitch P of the grooves 4 decreases from the base end side to the tip end side of the guidewire 1, or the width W or depth D of the grooves 4 increases from the base end side to the tip end side of the guidewire 1. With such a configuration, the flexibility of the tip portion 1a of the guidewire 1 can be efficiently increased while ensuring the pushability of the first coil body 2.

[0052] 8, a guidewire 1 according to a second embodiment of the present disclosure includes a core portion 8, a coil body 2, and a covering portion 10. The covering portion 10 includes an inner covering layer 10e and an outer covering layer 10f. The guidewire 1 according to this embodiment is suitable for insertion into blood vessels in the abdomen, head, etc.

[0053] The core portion 8 is linear and extends in the axial direction around the axis O, and is made of a metal material such as a superelastic alloy, such as a nickel (Ni)-titanium (Ti) alloy. The distal end of the core portion 8 has a radial dimension that decreases from the base end toward the distal end.

[0054] The coil body 2 is formed in a spiral shape with at least one wire 3 as the center, centered on the axis O. The coil body 2 forms a contrast marker. The coil body 2 is arranged so that the inner surface of the coil body 2 contacts the outer surface of the tip of the core portion 8. The coil body 2 forms only the tip portion 1a of the guide wire 1. Note that the coil body 2 may also be configured to form portions of the guide wire 1 other than the tip portion 1a. In the illustrated example, the coil body 2 forms a single spiral, but it may also be configured to form a double spiral or multiple spiral.

[0055] The inner coating layer 10e entirely covers the core portion 8 and the coil body 2. The inner coating layer 10e is made of, for example, a resin. The outer coating layer 10f entirely covers the inner coating layer 10e. The outer coating layer 10f is made of, for example, a hydrophilic polymer.

[0056] At least one wire 3 forming the coil body 2 has at least one groove 4 (not shown). That is, the coil body 2 has a groove portion 5. The groove portion 5 is provided in the same manner as in the first embodiment.

[0057] According to this embodiment, similar to the first embodiment, it is possible to increase flexibility while ensuring the X-ray contrast of the coil body 2. Furthermore, by appropriately setting the width W, depth D, and pitch P of the grooves 4 of the groove portion 5, it is possible to easily set the flexibility of the distal end portion 1a of the guide wire 1.

[0058] As in the first embodiment, the groove portion 5 can be modified in various ways, including the modifications shown in FIGS.

[0059] As shown in Fig. 9, a guidewire 1 according to a third embodiment of the present disclosure includes a coil body 2, a core wire 11, a safety wire 12, a distal end member 13, and a proximal end member 14. The coil body 2 forms a portion of the guidewire 1 that extends from the distal end 1a to the proximal end 1b. The guidewire 1 according to this embodiment is suitable for angiography, for example. The distal end 1a of the guidewire 1 is curved in a J-shape in its natural state before elastic deformation.

[0060] The distal member 13 is fixed to the distal end of the coil body 2. The proximal member 14 is fixed to the proximal end of the coil body 2. The core wire 11 extends axially radially inside the coil body 2 and strengthens the stiffness of the coil body 2. The distal end of the core wire 11 is tapered from the proximal end side to the distal end side. The proximal end of the core wire 11 is connected to the proximal member 14. The safety wire 12 extends axially radially inside the coil body 2 and is connected to the distal member 13 at its distal end and to the proximal member 14 at its proximal end, maintaining the overall shape of the guide wire 1.

[0061] The coil body 2 is formed by at least one wire 3 in a spiral shape centered on the axis O. At least one wire 3 forming the coil body 2 has at least one groove 4 (not shown). In other words, the coil body 2 has a groove portion 5. The groove portion 5 is provided in the same manner as in the first embodiment. In the illustrated example, the coil body 2 has a single spiral shape, but it may also have a double spiral or multiple spiral shape.

[0062] According to this embodiment, it is possible to easily increase the flexibility of the coil body 2. Furthermore, by appropriately setting the width W, depth D, and pitch P of the grooves 4 of the groove portion 5, it is possible to easily set the flexibility of the distal end portion 1a of the guide wire 1.

[0063] As in the first embodiment, the groove portion 5 can be modified in various ways, including the modifications shown in FIGS.

[0064] The core wire 11 is not limited to being tapered. The core wire 11 is not limited to being connected to the proximal end member 14. For example, the proximal end of the core wire 11 may be fixed to the coil body 2 via a brazing material or the like. The safety wire 12 is not limited to being connected to the proximal end member 14. For example, the proximal end of the safety wire 12 may be fixed to the coil body 2 via a brazing material or the like.

[0065] 10, a guidewire 1 according to a fourth embodiment of the present disclosure has a configuration similar to that of the third embodiment, except that a distal end portion 1a of the guidewire 1 is linear in its natural state. This embodiment also provides the same effects as the third embodiment.

[0066] The present disclosure is not limited to the above-described embodiments, and various modifications are possible without departing from the spirit of the present disclosure.

[0067] Therefore, the guide wire 1 according to the above-described embodiment can be modified in various ways as long as it is a guide wire 1 having at least one wire 3 forming a coil body 2, and at least one wire 3 having at least one groove 4.

[0068] It is preferable that the guidewire 1 according to the above-described embodiment is a guidewire 1 in which at least one groove 4 is provided only in the distal end portion 1a of the guidewire 1.

[0069] The guidewire 1 according to the above-described embodiment is preferably a guidewire 1 in which at least one groove 4 has a pitch P that decreases from the proximal end side to the distal end side of the guidewire 1.

[0070] The guidewire 1 according to the above-described embodiment is preferably a guidewire 1 in which the width W or depth D of at least one groove 4 increases from the proximal end side to the distal end side of the guidewire 1.

[0071] The guide wire 1 according to the above-described embodiment is preferably a guide wire 1 in which at least one wire 3 forms a radiopaque marker.

[0072] It is preferable that the guide wire 1 according to the above-described embodiment is a guide wire 1 in which at least one wire 3 forms the distal end 1a of the guide wire 1 or a portion extending from the distal end 1a to the proximal end 1b of the guide wire 1.

[0073] The guide wire 1 according to the above-described embodiment is preferably a guide wire 1 in which at least one groove 4 is provided in at least one wire 3 over the entire circumference of the guide wire 1 .

[0074] It is also preferable that the guide wire 1 according to the above-described embodiment is a guide wire 1 in which at least one groove 4 is not provided in a portion of at least one wire 3 aligned in a first direction perpendicular to the axial direction of the guide wire 1, but is provided in a portion of at least one wire 3 aligned in a second direction perpendicular to both the axial direction and the first direction of the guide wire 1.

[0075] In this case, the guide wire 1 is preferably a guide wire 1 in which at least one groove 4 is provided on both sides or only one side in the second direction of at least one wire 3 itself. It is also preferable that the guide wire 1 is a guide wire 1 in which at least one groove 4 is provided on both sides or only one side in the axial direction of at least one wire 3 itself.

[0076] The guidewire 1 according to the above-described embodiment is preferably a guidewire 1 in which at least one groove 4 extends in the axial direction of the guidewire 1. In this case, the guidewire 1 is preferably a guidewire 1 in which at least one groove 4 is provided only in a portion of at least one wire 3 that is located radially outward of the guidewire 1.

[0077] The guide wire 1 according to the above-described embodiment is also preferably a guide wire 1 in which at least one groove 4 is provided in a spiral or annular shape on the outer circumferential surface of at least one wire 3 itself.

[0078] The method for manufacturing the guide wire 1 according to the above-described embodiment is preferably a method for manufacturing the guide wire 1 that includes an irradiation step of forming at least one groove 4 by irradiating laser light onto at least one wire 3 in a state in which the coil body 2 has been formed. [Explanation of symbols]

[0079] 1 Guidewire 1a Tip of guidewire 1b Proximal end of guidewire 2 First coil body (coil body) 3 wire 4 grooves 4a side 4b Bottom 5 Groove section 6 Second coil body 7 Coil section 8 Core 8a 1st Core 8b Second Core 8c Base end face of first core 9 Fixed part 9a 1st fixing material 9b Second fixing material 9c 3rd fixing material 10 Covering part 10a First coating layer 10b 2nd coating layer 10c 3rd coating layer 10d 4th coating layer 10e inner coating layer 10f outer coating layer 11 Core wire 12 Safety Wire 13 Tip member 14 Base end member D Depth O axis Pitch W width

Claims

1. A guidewire having at least one wire forming a coil body, the at least one wire having at least one groove, A guide wire in which the at least one groove is not provided in a portion of the at least one wire aligned in a first direction perpendicular to the axial direction of the guide wire, but is provided in a portion of the at least one wire aligned in a second direction perpendicular to both the axial direction of the guide wire and the first direction.

2. The guide wire according to claim 1 , wherein the at least one groove is provided on both or only one surface of the at least one strand itself in the second direction.

3. The guidewire according to claim 1 , wherein the at least one groove is provided on both sides or only one side of the at least one strand itself in the axial direction of the guidewire.

4. A guidewire having at least one wire forming a coil body, the at least one wire having at least one groove, The at least one groove extends axially along the guidewire.

5. The guidewire according to claim 4 , wherein the at least one groove is provided only in a portion of the at least one strand positioned radially outward of the guidewire.

6. The guidewire according to claim 1 , wherein the at least one groove is provided in a spiral or annular shape on the outer circumferential surface of the at least one strand itself.

7. 6. The method for manufacturing a guide wire according to claim 1, further comprising an irradiation step of irradiating the at least one wire with laser light in a state in which the coil body is formed, thereby forming the at least one groove.

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