Leave-on disinfectant cleaning composition

Abstract

This no-rinse antibacterial detergent composition contains (A) at least one item selected from benzalkonium chloride, benzethonium chloride and cetylpyridinium chloride, (B) at least one item selected from a carboxyvinyl polymer, an alkyl-modified carboxyvinyl polymer, hydrophobically modified hydroxypropyl methylcellulose and hydroxypropyl cellulose, (C) medium chain fatty acid glyceryl, and (D) at least one basic amino acid selected from arginine, lysine, and histidine, and / or a salt thereof, wherein the content of (E) a C1-3 monohydric alcohol is less than 10 mass%.

Description

[Technical Field]

[0001] The present invention relates to a leave-on disinfectant cleaning composition. [Background technology]

[0002] BACKGROUND ART Conventionally, leave-on disinfectant detergent compositions used as disinfectant detergents for hands and fingers are required to have disinfecting power, be low in irritation to the skin, and have excellent stability.

[0003] Ethanol preparations are often used as such disinfectants and cleaners for hands. However, ethanol has problems such as an alcohol odor and irritation during use, and dryness of the skin after use. On the other hand, when the amount of ethanol is reduced to reduce the alcohol irritation, there is a problem that the feeling of use, such as stickiness after drying, deteriorates (see Patent Document 1).

[0004] In response to this, a germicidal and disinfectant gel composition for external use has been proposed that reduces stickiness after application, has a refreshing feeling and moisturizing properties, and does not cause rough skin (see Patent Document 2). However, this proposed composition also has the problem that it is not fully satisfactory in terms of disinfecting power, ease of application when rubbed in, and other aspects of the feel when used.

[0005] Therefore, a leave-in type bactericidal cleaning agent composition that has excellent bactericidal activity, is low in irritation to the skin of the hands during use, is easy to spread on the hands immediately after application, is easy to blend when rubbed in, is non-sticky when drying, leaves a refreshing feeling after drying, and is excellent in stability has not yet been provided, and there is currently a strong demand for its prompt development. [Prior art documents] [Patent documents]

[0006] [Patent Document 1] International Publication No. 2019 / 130748 [Patent Document 2] Japanese Patent Application Laid-Open No. 2002-80401 Summary of the Invention [Problem to be solved by the invention]

[0007] The present invention aims to solve the above-mentioned problems of the prior art and to achieve the following objects: That is, the present invention aims to provide a leave-in germicidal cleaning composition that has excellent germicidal activity, is low in irritation to the skin of hands during use, is easy to spread on the hands immediately after application, is easy to rub in, is non-sticky when drying, leaves a refreshing feeling after drying, and is excellent in stability. [Means for solving the problem]

[0008] As a result of intensive research to achieve the above-mentioned object, the present inventors have found that a leave-in disinfectant cleaning composition can be obtained that contains (A) at least one quaternary ammonium compound selected from benzalkonium chloride, benzethonium chloride, and cetylpyridinium chloride, (B) at least one water-soluble polymer selected from carboxyvinyl polymers, alkyl-modified carboxyvinyl polymers, hydrophobized hydroxypropyl methylcellulose, and hydroxypropyl cellulose, (C) a medium-chain fatty acid glyceryl, and (D) at least one basic amino acid selected from arginine, lysine, and histidine and at least one salt thereof, and that the content of (E) a monohydric alcohol having 1 to 3 carbon atoms is kept to less than 10% by mass, which has excellent disinfecting power, low irritation to the skin of the hands during use, ease of spreading on the hands immediately after application, ease of blending when rubbed in, no stickiness when drying, a refreshing feeling after drying, and excellent stability, thereby completing the present invention.

[0009] The present invention is based on the above findings by the present inventors, and the means for solving the above problems are as follows: <1> (A) at least one quaternary ammonium compound selected from benzalkonium chloride, benzethonium chloride, and cetylpyridinium chloride; (B) at least one water-soluble polymer selected from a carboxyvinyl polymer, an alkyl-modified carboxyvinyl polymer, a hydrophobized hydroxypropyl methylcellulose, and a hydroxypropyl cellulose; (C) medium-chain fatty acid glyceryl; (D) at least one basic amino acid selected from arginine, lysine, and histidine and / or a salt thereof; (E) A leave-on disinfectant cleaning composition characterized in that the content of a monohydric alcohol having 1 to 3 carbon atoms is less than 10% by mass. <2> The mass ratio [(D) / (C)] of the content (mass%) of the component (D) to the content (mass%) of the component (C) is 0.05 to 0.33. <1> The disinfectant composition is a leave-on type disinfectant cleaning agent composition described in the above. <3> The content of the (A) component is 0.01% by mass to 0.2% by mass, the content of the (B) component is 0.1% by mass to 0.5% by mass, the content of the (C) component is 0.4% by mass to 0.8% by mass, and the content of the (D) component is 0.1% by mass to 0.3% by mass. <1> from <2> The leave-on germicidal cleaning composition according to any one of the above items. <4> The composition further contains (F) 0.05% by mass to 0.5% by mass of at least one surfactant selected from nonionic surfactants, amphoteric surfactants, and semi-polar surfactants. <1> from <3> The leave-on germicidal cleaning composition according to any one of the above items. <5> The above-mentioned disinfectant detergent compositions excluding those containing alkyl glyceryl ether or alkenyl glyceryl ether having 4 to 12 carbon atoms <1> from <4> The leave-on germicidal cleaning composition according to any one of the above items. [Effects of the Invention]

[0010] According to the present invention, the above-mentioned problems of the prior art can be solved, the above-mentioned objects can be achieved, and a leave-in type bactericidal cleaning agent composition can be provided which has excellent bactericidal power, is low in irritation to the skin of the hands during use, is easy to spread on the hands immediately after application, is easy to rub in, is non-sticky when drying, leaves a refreshing feeling after drying, and is excellent in stability. DETAILED DESCRIPTION OF THE INVENTION

[0011] (Leave-on disinfectant composition) The leave-on germicidal detergent composition of the present invention contains (A) at least one quaternary ammonium compound selected from benzalkonium chloride, benzethonium chloride, and cetylpyridinium chloride, (B) at least one water-soluble polymer selected from carboxyvinyl polymers, alkyl-modified carboxyvinyl polymers, hydrophobized hydroxypropyl methylcellulose, and hydroxypropyl cellulose, (C) a medium-chain fatty acid glyceryl, and (D) at least one basic amino acid selected from arginine, lysine, and histidine and at least one salt thereof, and preferably further contains (F) at least one surfactant selected from nonionic surfactants, amphoteric surfactants, and semi-polar surfactants, and may further contain other ingredients as necessary. The leave-on germicidal detergent composition of the present invention may contain (E) a monohydric alcohol having 1 to 3 carbon atoms, but the content thereof is less than 10 mass %.

[0012] <(A) Quaternary ammonium compounds> The quaternary ammonium compound as component (A) is contained mainly to improve the disinfecting power.

[0013] The quaternary ammonium compound of the component (A) is at least one selected from benzalkonium chloride, benzethonium chloride, and cetylpyridinium chloride, with benzalkonium chloride being preferred from the standpoint of bactericidal power.

[0014] The quaternary ammonium compound of the component (A) may be suitably synthesized or may be a commercially available product. Commercially available benzalkonium chloride products as the quaternary ammonium compound of component (A) include, for example, CATION G-50 (manufactured by Sanyo Chemical Industries, Ltd.), NIKKOL CA-101 (manufactured by Nikko Chemicals Co., Ltd.), NISSAN CATION (registered trademark) M2-100R (manufactured by NOF Corporation), and NISSAN CATION (registered trademark) F2-50E (manufactured by NOF Corporation). Commercially available benzethonium chloride as the quaternary ammonium compound of the component (A) includes, for example, trade names such as Lonzagard Benzethonium Chloride (manufactured by Mitsubishi Chemical Chemical Foods Corporation) and Benzethonium Chloride (manufactured by Tokyo Chemical Industry Co., Ltd.). An example of a commercially available product of cetylpyridinium chloride as the quaternary ammonium compound of the component (A) is cetylpyridinium chloride (CPC) (manufactured by Fujifilm Wako Pure Chemical Industries, Ltd.).

[0015] The content of the quaternary ammonium compound of the component (A) is not particularly limited and can be appropriately selected depending on the purpose. The lower limit can be, for example, 0.005% by mass or more, 0.01% by mass or more, based on the total amount of the leave-on germicidal detergent composition. The upper limit can be, for example, 0.5% by mass or less, 0.2% by mass or less, based on the total amount of the leave-on germicidal detergent composition. From the viewpoints of germicidal activity and irritation to hand skin, the content is preferably 0.005% by mass to 0.5% by mass, more preferably 0.01% by mass to 0.2% by mass. When the content of the quaternary ammonium compound of the component (A) is 0.005% by mass or more, the germicidal activity is good, and when it is 0.5% by mass or less, the irritation to hand skin is low.

[0016] <(B) Water-soluble polymer> The water-soluble polymer as component (B) is contained mainly to improve the ease of spreading on the hands immediately after application.

[0017] The water-soluble polymer of component (B) is at least one selected from carboxyvinyl polymer, alkyl-modified carboxyvinyl polymer, hydrophobized hydroxypropyl methylcellulose, and hydroxypropyl cellulose, but carboxyvinyl polymer is preferred from the viewpoint of ease of spreading on hands immediately after application.

[0018] The water-soluble polymer of the component (B) may be either an appropriately synthesized product or a commercially available product. Examples of commercially available carboxyvinyl polymers as the water-soluble polymer of component (B) include Carbopol (registered trademark) 981 (manufactured by Lubrizol Japan Co., Ltd.), Carbopol (registered trademark) ETD2050 (manufactured by Lubrizol Japan Co., Ltd.), Carbopol (registered trademark) 980 (manufactured by Lubrizol Japan Co., Ltd.), and Carbopol (registered trademark) Ultrez10 (manufactured by Lubrizol Japan Co., Ltd.). Commercially available alkyl-modified carboxyvinyl polymers as the water-soluble polymer of component (B) include, for example, Carbopol (registered trademark) 1382 (manufactured by Lubrizol Japan Co., Ltd.) and Carbopol (registered trademark) ETD2020 (manufactured by Lubrizol Japan Co., Ltd.). Commercially available hydrophobized hydroxypropyl methylcellulose as the water-soluble polymer of component (B) includes, for example, trade names such as Sangelose (registered trademark) 60L (manufactured by Daido Chemical Industry Co., Ltd.) and Sangelose (registered trademark) 90L (manufactured by Daido Chemical Industry Co., Ltd.). Commercially available alkyl-modified carboxyvinyl polymers as the water-soluble polymer of component (B) include, for example, NISSO HPC (manufactured by Nippon Soda Co., Ltd.) and L-HPC (registered trademark) (manufactured by Shin-Etsu Chemical Co., Ltd.).

[0019] The content of the water-soluble polymer of the (B) component is not particularly limited and can be appropriately selected according to the purpose. The lower limit thereof is, for example, 0.05% by mass or more, 0.1% by mass or more, based on the total amount of the leave-on type germicidal detergent composition. The upper limit thereof is, for example, 2% by mass or less, 0.5% by mass or less, based on the total amount of the leave-on type germicidal detergent composition. From the viewpoint of ease of spreading on hands immediately after application and ease of blending when rubbed in, the content is preferably 0.05% by mass to 2% by mass, more preferably 0.1% by mass to 0.5% by mass. When the content of the water-soluble polymer of the (B) component is 0.05% by mass or more, the ease of spreading on hands immediately after application is good, and when it is 2% by mass or less, the ease of blending when rubbed in is good.

[0020] <(C) Medium-chain fatty acid glyceryl> The medium-chain fatty acid glyceryl as component (C) is contained mainly to improve the antiseptic power and ease of application when rubbed in.

[0021] The medium-chain fatty acid glyceryl of component (C) is not particularly limited and can be appropriately selected depending on the purpose, and examples include glyceryl caprylate, glyceryl caprate, etc. These may be used alone or in combination of two or more. Among these, glyceryl caprylate is preferred in terms of its antibacterial power, ease of application when rubbed in, lack of stickiness when drying, and refreshing feeling after drying.

[0022] The medium-chain fatty acid glyceryl of the component (C) may be appropriately synthesized or may be a commercially available product. Commercially available glyceryl caprylate as the medium-chain fatty acid glyceryl of component (C) includes, for example, trade names such as Sunsoft No. 700P-2-C (manufactured by Taiyo Kagaku Co., Ltd.), Sunsoft No. 707-C (manufactured by Taiyo Kagaku Co., Ltd.), Sunpurala GC (manufactured by Taiyo Kagaku Co., Ltd.), IMWITOR 988 (manufactured by Watahan Trading Co., Ltd.), Lexgard (registered trademark) GMCY MB (manufactured by Inolex Chemical Company), Poem M-100 (manufactured by Riken Vitamin Co., Ltd.), and Homotex PT (manufactured by Kao Corporation). An example of a commercially available product of glyceryl caprate as the medium-chain fatty acid glyceryl of the component (C) is Sunsoft No. 760-C (manufactured by Taiyo Kagaku Co., Ltd.).

[0023] The content of the medium-chain fatty acid glyceryl of the component (C) is not particularly limited and can be appropriately selected depending on the purpose. The lower limit can be, for example, 0.05% by mass or more, 0.4% by mass or more, and the upper limit can be, for example, 1% by mass or less, 0.8% by mass or less, based on the total amount of the leave-on germicidal detergent composition. However, from the viewpoints of bactericidal power, ease of application when rubbed in, non-stickiness when drying, and a refreshing feeling after drying, the content is preferably 0.05% by mass to 1% by mass, more preferably 0.4% by mass to 0.8% by mass, based on the total amount of the leave-on germicidal detergent composition. When the content of the medium-chain fatty acid glyceryl of the component (C) is 0.05% by mass or more, the bactericidal power and ease of application when rubbed in are good, and when it is 1% by mass or less, the non-stickiness when drying and the refreshing feeling after drying are good.

[0024] <(D) At least one of a basic amino acid and a salt thereof> At least one of a basic amino acid and a salt thereof as the component (D) is contained mainly to improve the lack of stickiness when drying, the refreshing feeling after drying, and stability.

[0025] The basic amino acid and / or salt thereof of component (D) is at least one basic amino acid selected from arginine, lysine, and histidine and / or salt thereof, but lysine and / or salts of lysine are preferred from the viewpoints of ease of application during rubbing, non-stickiness upon drying, refreshing feeling after drying, and stability.

[0026] The salt of the basic amino acid of component (D) is not particularly limited as long as it is a pharmaceutically acceptable salt and can be appropriately selected depending on the purpose, but hydrochloride and acetate are preferred.

[0027] The relative configuration of at least one of the basic amino acid and salt thereof in component (D) is not particularly limited and can be appropriately selected depending on the purpose. It may be an L-form, a D-form, or a mixture of both in any ratio. Furthermore, the optical rotation of at least one of the basic amino acid and its salt in component (D) is not particularly limited and can be appropriately selected depending on the purpose, and may be levorotatory (-), dextrorotatory (+), or racemic.

[0028] At least one of the basic amino acid and its salt as component (D) may be suitably synthesized or may be a commercially available product. Commercially available products of arginine or a salt thereof as at least one of the basic amino acids and salts thereof of component (D) include, for example, L-Arginine Kyowa (manufactured by Kyowa Hakko Bio Co., Ltd.), L-Arginine Hydrochloride (manufactured by Kyowa Hakko Bio Co., Ltd.), L(+)-Arginine Hydrochloride (manufactured by Fujifilm Wako Pure Chemical Industries, Ltd.), and L-(+)-Arginine Monohydrochloride (manufactured by Nacalai Tesque, Inc.). Commercially available products of lysine or a salt thereof as at least one of the basic amino acid and a salt thereof of component (D) include, for example, L-lysine hydrochloride (manufactured by Kyowa Hakko Bio Co., Ltd.), L-lysine hydrochloride (manufactured by Ajinomoto Healthy Supply Co., Ltd.), L-lysine hydrochloride (manufactured by Fujifilm Wako Pure Chemical Industries, Ltd.), L-lysine monohydrochloride (manufactured by Nacalai Tesque Inc.), and L-(+)-lysine monohydrochloride (manufactured by Tokyo Chemical Industry Co., Ltd.). Commercially available histidine or a salt thereof as at least one of the basic amino acid and a salt thereof of component (D) includes, for example, L-histidine (manufactured by Kyowa Hakko Bio Co., Ltd.), L-histidine hydrochloride hydrate (manufactured by Kyowa Hakko Bio Co., Ltd.), L-histidine monohydrochloride monohydrate (manufactured by Nacalai Tesque Inc.), and L-histidine hydrochloride monohydrate (manufactured by Fujifilm Wako Pure Chemical Industries, Ltd.).

[0029] The content of at least one of the basic amino acid and its salt of the component (D) is not particularly limited and can be appropriately selected according to the purpose. The lower limit thereof is, for example, 0.01% by mass or more, 0.1% by mass or more, based on the total amount of the leave-on type germicidal detergent composition. The upper limit thereof is, for example, 0.5% by mass or less, 0.3% by mass or less, based on the total amount of the leave-on type germicidal detergent composition. However, from the viewpoint of ease of application when rubbed in, non-stickiness when dried, refreshing feeling after drying, and stability, it is preferably 0.01% by mass to 0.5% by mass, more preferably 0.1% by mass to 0.3% by mass. When the content of at least one of the basic amino acid and its salt of the component (D) is 0.01% by mass or more, the non-stickiness when dried, refreshing feeling after drying, and stability are good, and when it is 0.5% by mass or less, the ease of application when rubbed in is good.

[0030] <Mass ratio [(D) / (C)]> The mass ratio [(D) / (C)] of the content (mass%) of the component (D) to the content (mass%) of the component (C) is not particularly limited and can be appropriately selected depending on the purpose. The lower limit can be, for example, 0.05 or more, or 0.1 or more, and the upper limit can be, for example, 0.33 or less, or 0.3 or less. From the viewpoints of ease of application during rubbing, non-stickiness upon drying, and a refreshing feeling after drying, a range of 0.05 to 0.33 is preferred, and 0.1 to 0.3 is more preferred. When the mass ratio [(D) / (C)] is 0.05 or more, the non-stickiness upon drying and the refreshing feeling after drying are good, and when it is 0.33 or less, the ease of application during rubbing is good.

[0031] <(E) Monohydric Alcohol Having 1 to 3 Carbon Atoms> The leave-on germicidal detergent composition may contain a monohydric alcohol having 1 to 3 carbon atoms as the component (E).

[0032] The monohydric alcohol having 1 to 3 carbon atoms of the component (E) is not particularly limited and can be appropriately selected depending on the purpose, and examples thereof include ethanol, isopropyl alcohol, etc. These may be used alone or in combination of two or more.

[0033] The monohydric alcohol having 1 to 3 carbon atoms of the component (E) may be appropriately synthesized or may be a commercially available product. Examples of commercially available monohydric alcohols having 1 to 3 carbon atoms as component (E) include 95% synthetic specified alcohol (ethanol, manufactured by Shinwa Alcohol Industry Co., Ltd.) and isopropyl alcohol (manufactured by Godo Solvent Co., Ltd.).

[0034] The content of the monohydric alcohol having 1 to 3 carbon atoms in the component (E) is less than 10% by mass, preferably 5% by mass or less, and more preferably 0.01% by mass or less, of the total amount of the leave-on germicidal detergent composition, from the viewpoint of irritation to hand skin. If the content of the monohydric alcohol having 1 to 3 carbon atoms in the component (E) is 10% by mass or more, irritation to hand skin becomes strong.

[0035] <(F) Surfactant> The component (F) of at least one surfactant selected from nonionic surfactants, amphoteric surfactants, and semi-polar surfactants is contained mainly to improve stability.

[0036] -Nonionic surfactants- The nonionic surfactant is not particularly limited and can be appropriately selected depending on the purpose, and examples thereof include polyoxyethylene hydrogenated castor oil, etc. These may be used alone or in combination of two or more.

[0037] The average number of moles of ethylene oxide added in the polyoxyethylene hydrogenated castor oil is not particularly limited and can be appropriately selected depending on the purpose, but is preferably 40 to 100, and more preferably 40 to 60. When the average number of moles of ethylene oxide added in the polyoxyethylene hydrogenated castor oil is 40 or more, the stability is good, and when it is 100 or less, the refreshing feeling after drying is good.

[0038] Specific examples of the polyoxyethylene hydrogenated castor oil include polyoxyethylene (40) hydrogenated castor oil, polyoxyethylene (60) hydrogenated castor oil, and polyoxyethylene (100) hydrogenated castor oil. In the polyoxyethylene hydrogenated castor oil, the number in parentheses indicates the average number of moles of ethylene oxide added.

[0039] The nonionic surfactant of the component (F) may be suitably synthesized or may be a commercially available product. Examples of commercially available nonionic surfactants for component (F) include EMALEX HC-40 (polyoxyethylene (40) hydrogenated castor oil, HLB: 12, manufactured by Nippon Emulsion Co., Ltd.), EMALEX HC-60 (polyoxyethylene (60) hydrogenated castor oil, HLB: 14, manufactured by Nippon Emulsion Co., Ltd.), and EMALEX HC-100 (polyoxyethylene (100) hydrogenated castor oil, HLB: 15, manufactured by Nippon Emulsion Co., Ltd.).

[0040] -Amphoteric surfactant- The amphoteric surfactant is not particularly limited and can be appropriately selected depending on the purpose, and examples thereof include alkylbetaine-type amphoteric surfactants, amidobetaine-type amphoteric surfactants, sulfobetaine-type amphoteric surfactants, imidazoline-type amphoteric surfactants, etc. These may be used alone or in combination of two or more.

[0041] The alkyl betaine type amphoteric surfactant is not particularly limited and can be appropriately selected depending on the purpose, and examples thereof include lauryl dimethyl amino acetic acid betaine, coconut oil alkyl betaine, stearyl dimethyl amino acetic acid betaine, lauryl betaine, etc. These may be used alone or in combination of two or more.

[0042] The amidobetaine amphoteric surfactant is not particularly limited and can be appropriately selected depending on the purpose, and examples thereof include lauric acid amidopropyl betaine, lauric acid amidopropyl dimethylaminoacetic acid betaine, coconut oil fatty acid amidopropyl betaine, coconut oil fatty acid amidopropyl dimethylaminoacetic acid betaine, palm kernel oil fatty acid amidopropyl betaine, palm kernel oil fatty acid amidopropyl dimethylaminoacetic acid betaine, etc. These may be used alone or in combination of two or more.

[0043] The sulfobetaine-type amphoteric surfactant is not particularly limited and can be appropriately selected depending on the purpose, and examples thereof include lauryl hydroxysulfobetaine, lauramidopropyl hydroxysultaine, etc. These may be used alone or in combination of two or more.

[0044] The imidazoline-type amphoteric surfactant is not particularly limited and can be appropriately selected depending on the purpose. Examples thereof include 2-alkyl-N-carboxymethyl-N-hydroxyethylimidazolinium betaine, N-lauroyl-N'-carboxymethyl-N'-hydroxyethylethylenediamine sodium, and N-coconut oil fatty acid acyl-N'-carboxyethyl-N'-hydroxyethylethylenediamine sodium.

[0045] The amphoteric surfactant of the component (F) may be an appropriately synthesized product or a commercially available product. Commercially available alkyl betaine amphoteric surfactants as the amphoteric surfactant of component (F) include, for example, Nissan Anon (registered trademark) BL (lauryl dimethylaminoacetic acid betaine, manufactured by NOF Corporation), Nissan Anon (registered trademark) BF (coconut oil dimethylaminoacetic acid betaine, manufactured by NOF Corporation), NIKKOL Examples of such an agent include AM-301 (lauryl dimethyl aminoacetic acid betaine, manufactured by Nikko Chemicals Co., Ltd.), Amogene S (lauryl betaine, manufactured by Daiichi Kogyo Seiyaku Co., Ltd.), Obazoline LB (lauryl dimethyl aminoacetic acid betaine, manufactured by Toho Chemical Industry Co., Ltd.), Rekabion A-100 (lauryl dimethyl aminoacetic acid betaine solution, manufactured by New Japan Chemical Co., Ltd.), Anhithol 20BS (lauryl dimethyl aminoacetic acid betaine, manufactured by Kao Corporation), Anhithol 24B (lauryl dimethyl aminoacetic acid betaine, manufactured by Kao Corporation), Anhithol 86B (stearyl dimethyl aminoacetic acid betaine, manufactured by Kao Corporation), and Rekabion A-700 (stearyl betaine, manufactured by New Japan Chemical Co., Ltd.).

[0046] Commercially available amidobetaine amphoteric surfactants as the amphoteric surfactant of component (F) include, for example, trade names such as NIKKOL AM-3130N (coconut oil fatty acid amidopropyl betaine liquid, manufactured by Nikko Chemicals Co., Ltd.), Nissan Anon (registered trademark) BDL-SF (lauric acid amidopropyl dimethylaminoacetic acid betaine, manufactured by NOF Corporation), Nissan Anon (registered trademark) BDF-SF (coconut oil fatty acid amidopropyl dimethylaminoacetic acid betaine, manufactured by NOF Corporation), Nissan Anon (registered trademark) BDC-SF (palm kernel oil fatty acid amidopropyl dimethylaminoacetic acid betaine, manufactured by NOF Corporation), and Amphithol 2 Examples include 0AB (lauric acid amidopropyl betaine solution, manufactured by Kao Corporation), Amphitol 55AB (coconut oil fatty acid amidopropyl betaine solution, manufactured by Kao Corporation), Softazoline CPB (coconut oil fatty acid amidopropyl betaine solution, manufactured by Kawaken Fine Chemicals Co., Ltd.), Softazoline LPB (lauric acid amidopropyl betaine solution, manufactured by Kawaken Fine Chemicals Co., Ltd.), and Softazoline PKPB (palm kernel oil fatty acid amidopropyl betaine solution, manufactured by Kawaken Fine Chemicals Co., Ltd.).

[0047] Commercially available sulfobetaine-type amphoteric surfactants as the amphoteric surfactant component (F) include, for example, trade names such as Amphitol 20HD (lauryl hydroxysulfobetaine liquid, manufactured by Kao Corporation) and Softazoline LSB (lauramidopropyl hydroxysultaine, manufactured by Kawaken Fine Chemicals Co., Ltd.).

[0048] Commercially available imidazoline-type amphoteric surfactants as the amphoteric surfactant of component (F) include, for example, trade names such as NIKKOL AM-101 (2-alkyl-N-carboxymethyl-N-hydroxyethyl imidazolinium betaine, manufactured by Nikko Chemicals Co., Ltd.), Nissan Anon (registered trademark) GLM-R-LV (2-alkyl-N-carboxymethyl-N-hydroxyethyl imidazolinium betaine, manufactured by NOF Corporation), Amphitol 20Y-B (2-alkyl-N-carboxymethyl-N-hydroxyethyl imidazolinium betaine, manufactured by Kao Corporation), and Softazoline CH (2-alkyl-N-carboxymethyl-N-hydroxyethyl imidazolinium betaine, manufactured by Kao Corporation). Softazoline CL (2-alkyl-N-carboxymethyl-N-hydroxyethyl imidazolinium betaine, manufactured by Kawaken Fine Chemicals Co., Ltd.), Softazoline LHL (N-lauroyl-N'-carboxymethyl-N'-hydroxyethylethylenediamine sodium solution, manufactured by Kawaken Fine Chemicals Co., Ltd.), Softazoline SFD (N-coconut oil fatty acid acyl-N'-carboxyethyl-N'-hydroxyethylethylenediamine sodium, manufactured by Kawaken Fine Chemicals Co., Ltd.).

[0049] -Semi-polar surfactant- The semi-polar surfactant is not particularly limited and can be appropriately selected depending on the purpose. Examples thereof include alkyldimethylamine oxide.

[0050] The alkyl dimethyl amine oxide is not particularly limited and can be appropriately selected depending on the purpose, and examples thereof include lauryl dimethyl amine oxide, coconut oil alkyl dimethyl amine oxide, myristyl dimethyl amine oxide, lauric acid amide propyl dimethyl amine oxide, etc. These may be used alone or in combination of two or more.

[0051] The semi-polar surfactant of the component (F) may be an appropriately synthesized product or a commercially available product. Commercially available alkyldimethylamine oxides as the semi-polar surfactant of component (F) include, for example, trade names such as Amphitol 20N (lauryldimethylamine oxide liquid, manufactured by Kao Corporation), Softazoline LAO (lauric acid amidopropyldimethylamine oxide liquid, manufactured by Kawaken Fine Chemicals), AX-S (lauryldimethylamine oxide, manufactured by Lion Specialty Chemicals), Cadenax DMC-W (coconut oil alkyldimethylamine oxide liquid, manufactured by Lion Specialty Chemicals), Cadenax DM14D-N (myristyldimethylamine oxide, manufactured by Lion Specialty Chemicals), and Cadenax APA-12W (lauryldimethylamine oxide, manufactured by Lion Specialty Chemicals).

[0052] Among these, the surfactant of the component (F) is preferably a lauryl dimethylamine oxide liquid from the viewpoint of stability.

[0053] The content of the nonionic surfactant, amphoteric surfactant, and semi-polar surfactant in the component (F) is not particularly limited and can be appropriately selected depending on the purpose, but from the viewpoint of stability, it is preferably 0.05% by mass to 0.5% by mass based on the total amount of the leave-on germicidal detergent composition. When the content of the nonionic surfactant, amphoteric surfactant, and semi-polar surfactant in the component (F) is 0.05% by mass or more or 0.5% by mass or less, stability is good.

[0054] <Other ingredients> In addition to the components (A), (B), (C), (D), (E), and (F), the leave-in type germicidal detergent composition of the present invention may contain other components that are commonly used in germicidal detergent compositions, etc., as necessary, within the scope of the present invention.

[0055] The other components are not particularly limited and can be appropriately selected depending on the purpose, and examples thereof include water, water-soluble polymers other than the component (B), surfactants other than the component (F), oils, silicones, aromatic alcohols, lanolin derivatives, protein derivatives, pharmaceutical agents such as vitamins, bactericides other than the components (A) and (E), preservatives, pH adjusters, antioxidants, sequestering agents, ultraviolet absorbers, animal and plant extracts or derivatives thereof, pigments, fragrances, etc. These may be used alone or in combination of two or more. It is preferable that the leave-on germicidal detergent composition does not contain alkyl glyceryl ether or alkenyl glyceryl ether having 4 to 12 carbon atoms.

[0056] The pH adjuster is not particularly limited and can be appropriately selected depending on the purpose, but is preferably one that can neutralize the (B) component, thicken the leave-on type germicidal detergent composition, and adjust the pH of the leave-on type germicidal detergent composition, such as alkali metal hydroxides, alkanolamines, etc. These may be used alone or in combination of two or more. Examples of the alkali metal hydroxide include potassium hydroxide and sodium hydroxide. Examples of the alkanolamine include triethanolamine, 2-amino-2-methyl-1-propanol, and diisopropanolamine.

[0057] The content of the other components relative to the total amount of the leave-on type bactericidal cleaning composition is not particularly limited, and can be any content that is normally used as long as it does not interfere with the effects of the present invention.

[0058] -pH- The pH of the leave-on disinfectant cleaning composition is not particularly limited and can be selected appropriately depending on the purpose, but from the standpoints of disinfecting power, ease of spreading on hands immediately after application, irritation to hand skin, and stability, the pH at 25°C is preferably 6 or more and 11 or less, more preferably 7 or more and 8 or less. The pH can be measured in a 25° C. environment using, for example, a glass electrode hydrogen ion concentration indicator (device name: pH meter HM-30R type, manufactured by DKK-TOA Corporation, electrode type: GST-5721).

[0059] -Manufacturing method- The method for producing the leave-on type germicidal detergent composition is not particularly limited and can be appropriately selected depending on the purpose. For example, in an environment of room temperature (e.g., 25 ° C), the (B) component is added to water in small amounts while stirring, and uniformly dispersed. Next, the pH adjuster is added to neutralize, and then the (A), (C), and (D) components are added while stirring, and each component is dissolved. Then, if necessary, the (E), (F), and other components are added and mixed. Then, the pH adjuster is appropriately added while stirring, and the pH is adjusted to a predetermined value. In addition, it is preferable to add water so that the total amount of the leave-on type germicidal detergent composition becomes 100% by mass.

[0060] The leave-on type germicidal detergent composition may be prepared using an apparatus. The apparatus is not particularly limited and can be appropriately selected depending on the purpose, and examples thereof include a stirring apparatus equipped with stirring blades that exert shear force and can mix the entire composition. The stirring blade is not particularly limited and can be appropriately selected depending on the purpose. Examples thereof include a propeller, a turbine, and a disperser.

[0061] -Applications- The use of the leave-on type germicidal detergent composition is not particularly limited and can be appropriately selected depending on the purpose, but it can be suitably used as a hand disinfectant, etc. The leave-on type germicidal detergent composition can also be used on body parts other than hands. The application sites include, for example, hospitals, nursing homes, kitchens, etc., and it can also be suitably used at home. [Example]

[0062] The present invention will be specifically explained below with reference to examples and comparative examples, but the present invention is not limited to these examples in any way. The content of each component in the examples and comparative examples is expressed in mass %, and all values ​​are converted to pure content. However, for component (D), 95% synthetic specified alcohol (manufactured by Shinwa Alcohol Industry Co., Ltd.) was used, and the value converted to absolute ethanol (content (mass %) converted to absolute ethanol) was reported. Furthermore, the mass ratio of the content (mass %) of component (D) to the content (mass %) of component (C) [(D) / (C)] was rounded to two decimal places and reported.

[0063] (Examples 1 to 33 and Comparative Examples 1 to 9) The leave-on germicidal cleaning agent compositions of Examples 1 to 33 and Comparative Examples 1 to 9 were prepared according to the following manufacturing method, with the compositions and contents (mass%) shown in Tables 1 to 9 below.

[0064] -Preparation of leave-on disinfectant cleaning composition- In an environment of 25°C, component (B) or a comparative component for component (B) was added little by little to an appropriate amount of water while stirring, and uniformly dispersed to prepare a dispersion. Next, potassium hydroxide was added to the dispersion to neutralize it, and then component (A) or a comparative component for component (A), component (C), and component (D) or a comparative component for component (D) were added while stirring, and each component was dissolved to prepare a solution. Here, for Examples 17, 18, 30, and Comparative Examples 7 to 9, component (E) was further added to the solution and mixed. For Examples 31 to 33 and Comparative Example 9, component (F) was further added to the solution and mixed. Thereafter, potassium hydroxide was added appropriately to the solution while stirring, and the pH was adjusted to the desired level. Water was then added so that the total amount of each germicidal detergent composition was 100% by mass, and leave-on germicidal detergent compositions of Examples 1 to 33 and Comparative Examples 1 to 9 were obtained. A propeller was used as the stirring blade, and stirring was performed using a Three-One Motor (product name: HEIDON BL1200, manufactured by Shinto Chemical Co., Ltd.) The pH was measured at 25°C using a glass electrode hydrogen ion concentration indicator (device name: pH meter HM-30R type, manufactured by DKK-TOA Corporation, electrode type: GST-5721).

[0065] The obtained leave-in type germicidal detergent compositions of Examples 1 to 33 and Comparative Examples 1 to 9 were evaluated for "sterilizing power," "ease of spreading on hands immediately after application," "ease of blending when rubbed," "non-stickiness when dried," "refreshing feeling after drying," "irritation to hand skin," and "stability" based on the following evaluation methods. The evaluation results are shown in Tables 1 to 9 below.

[0066] <Bactericidal power> The target bacteria is E. coli ( Escherichia coli NBRC3972: Gram-negative bacteria, obtained from the National Institute for Product Evaluation and Research) and Staphylococcus aureus ( Staphylococcus aureusUsing NBRC12732 (Gram-positive bacteria, obtained from the National Institute for Product Evaluation and Research), the bactericidal activity of each of the leave-on germicidal detergent compositions of Examples 1 to 33 and Comparative Examples 1 to 9 was evaluated by a quantitative suspension method. The Escherichia coli and Staphylococcus aureus were statically cultured for 18 to 24 hours at 37°C under aerobic conditions using SCDLP agar medium (manufactured by Nippon Pharmaceutical Co., Ltd.). Next, an appropriate amount of colonies formed on the SCDLP agar medium was scraped off and suspended in physiological saline (Otsuka Pharmaceutical Co., Ltd.) until the bacterial concentration reached 10. 8 The test bacterial solution was prepared so that the concentration was cfu / mL, where cfu means colony forming unit. Next, 0.05 mL of the test bacterial solution was added to 0.45 mL of each of the leave-in germicidal cleaning compositions of Examples 1 to 33 and Comparative Examples 1 to 9, and mixed. After 30 seconds, the mixture was immediately diluted 10-fold with SCDLP liquid medium (manufactured by Nippon Pharmaceutical Co., Ltd.) for inactivation. The inactivated solution was then serially diluted 10-fold with SCDLP liquid medium, i.e., 100-fold, 1,000-fold, and 10,000-fold. Subsequently, 0.1 mL of each diluted inactivated solution (n=3) was inoculated onto SCDLP agar medium (manufactured by Nippon Pharmaceutical Co., Ltd., 9 cm Petri dishes) and statically cultured at 37°C for 24 hours under aerobic conditions using the pour plate culture method. After incubation, the total number of colonies formed was counted, and the number of remaining viable bacteria was measured. If no colonies were observed, the number of remaining viable bacteria was considered to be less than the detection limit of 10 cfu / mL. The "bactericidal power" was scored based on the measured number of remaining viable bacteria in accordance with the following criteria. The "bactericidal power" was evaluated based on the average of the scores in accordance with the following criteria. -Criteria for determining "sterilization power"- 5 points: The number of remaining viable bacteria is less than 10 cfu / mL (below the detection limit) 4 points: Residual viable bacteria count is 10 cfu / mL or more but less than 100 cfu / mL 3 points: Residual viable bacteria count is 100 cfu / mL or more but less than 1,000 cfu / mL 2 points: Residual viable bacteria count is 1,000 cfu / mL or more and less than 10,000 cfu / mL 1 point: Residual viable bacteria count is 10,000 cfu / mL or more -Evaluation criteria for "sterilization power"- ◎◎: The average score is between 4.0 and 5.0 points ◎: The average score is 3.5 points or more and less than 4.0 points ○: The average score is 3.0 or more and less than 3.5 points △: The average score is between 2.0 and 3.0 points ×: The average score is less than 2.0 points

[0067] <Easy to spread on hands immediately after application> In an environment of 25°C, 10 expert panelists (5 men and 5 women) scored the ease of spreading onto the hands when rubbing 0.5 g of each of the leave-in germicidal detergent compositions of Examples 1 to 33 and Comparative Examples 1 to 9 into the palms and backs of the hands, based on the following criteria. The "ease of spreading onto the hands immediately after application" was evaluated based on the average of the scores, based on the following criteria. -Criteria for judging "ease of spreading on hands immediately after application"- 5 points: Feels very easy to stretch 4 points: Feels easy to stretch 3 points: Feels somewhat easy to stretch 2 points: It feels a little difficult to stretch 1 point: I feel it is difficult to stretch -Evaluation criteria for "ease of spreading on hands immediately after application"- ◎◎: The average score is between 4.5 and 5.0 points ◎: The average score is 4.0 points or more and less than 4.5 points ○: The average score is 3.0 or more and less than 4.0 points △: The average score is 2.0 or more and less than 3.0 points ×: The average score is less than 2.0 points

[0068] <Easy to rub in> In an environment of 25°C, 10 expert panelists (5 men and 5 women) scored the ease of application when rubbing 0.5 g of each of the leave-in germicidal detergent compositions of Examples 1 to 33 and Comparative Examples 1 to 9 into the palms and backs of their hands, based on the following criteria. The "ease of application when rubbed in" was evaluated based on the average of the scores, based on the following criteria. -Criteria for judging "ease of blending when rubbed in"- 5 points: Feels very familiar 4 points: Feels familiar 3 points: Somewhat familiar 2 points: Not very familiar 1 point: Not feeling familiar -Evaluation criteria for "ease of blending when rubbed in"- ◎◎: The average score is between 4.5 and 5.0 points ◎: The average score is 4.0 points or more and less than 4.5 points ○: The average score is 3.0 or more and less than 4.0 points △: The average score is 2.0 or more and less than 3.0 points ×: The average score is less than 2.0 points

[0069] <Non-sticky when drying> In an environment of 25°C, 10 expert panelists (5 men and 5 women) rubbed 0.5 g of each of the leave-in germicidal detergent compositions of Examples 1 to 33 and Comparative Examples 1 to 9 into the palms and backs of their hands, and then scored the non-stickiness based on the following criteria. The average of the scores was used to evaluate the "non-stickiness upon drying" based on the following criteria. - Criteria for determining "non-stickiness when drying" - 5 points: No stickiness 4 points: Almost no stickiness 3 points: Slight stickiness, but not a problem 2 points: Sticky feeling 1 point: Strong stickiness -Evaluation criteria for "non-stickiness when drying"- ◎◎: The average score is between 4.5 and 5.0 points ◎: The average score is 4.0 points or more and less than 4.5 points ○: The average score is 3.0 or more and less than 4.0 points △: The average score is 2.0 or more and less than 3.0 points ×: The average score is less than 2.0 points

[0070] <Refreshing feeling after drying> In an environment of 25°C, 10 expert panelists (5 men and 5 women) rubbed 0.5 g of each of the leave-in germicidal detergent compositions of Examples 1 to 33 and Comparative Examples 1 to 9 into the palms and backs of their hands, and then scored the refreshing feeling according to the following criteria. The "refreshing feeling after drying" was evaluated based on the average of the scores according to the following criteria. -Criteria for judging "refreshing feeling after drying"- 5 points: Very refreshing feeling 4 points: Feels refreshing 3 points: Feels slightly refreshing 2 points: Not very refreshing 1 point: No refreshing feeling -Evaluation criteria for "refreshing feeling after drying"- ◎◎: The average score is between 4.5 and 5.0 points ◎: The average score is 4.0 points or more and less than 4.5 points ○: The average score is 3.0 or more and less than 4.0 points △: The average score is 2.0 or more and less than 3.0 points ×: The average score is less than 2.0 points

[0071] <Irritation to hands> In an environment of 25°C, 10 expert panelists (5 men and 5 women) rubbed 0.5 g of each of the leave-in germicidal detergent compositions of Examples 1 to 33 and Comparative Examples 1 to 9 into the palms and backs of their hands, and then scored the irritation to the skin of their hands based on the following criteria. The "irritation to the skin of the hands" was evaluated based on the average of the scores, based on the following criteria. -Criteria for determining "irritation to the skin on the hands"- 5 points: No irritation to the skin 4 points: Almost no irritation to the skin 3 points: Slight irritation to the skin, but not to a problem level 2 points: I feel irritation on my hands 1 point: Strong irritation to the skin on the hands -Evaluation criteria for "irritation to hand skin"- ◎◎: The average score is between 4.5 and 5.0 points ◎: The average score is 4.0 points or more and less than 4.5 points ○: The average score is 3.0 or more and less than 4.0 points △: The average score is 2.0 or more and less than 3.0 points ×: The average score is less than 2.0 points

[0072] <Stability> 50 mL of each leave-in type germicidal cleaning agent composition of Examples 1 to 33 and Comparative Examples 1 to 9 was filled into a 50 mL glass screw vial (product name: SV-50A, manufactured by Nichiden Rika Glass Co., Ltd.) and stored in a constant temperature bath at 60°C for 4 days. After that, one expert panelist visually observed the appearance of each leave-in type germicidal cleaning agent composition and evaluated its "stability" based on the following evaluation criteria. - "Stability" evaluation criteria - ◎◎: Uniform ◎: Almost uniform ○: Slight deposits are formed ×: Precipitation occurs and separation occurs

[0073] [Table 1]

[0074] [Table 2]

[0075] [Table 3]

[0076] [Table 4]

[0077] [Table 5]

[0078] [Table 6]

[0079] [Table 7]

[0080] [Table 8]

[0081] [Table 9]

[0082] The raw materials used in the leave-on germicidal detergent compositions used in Examples 1 to 33 and Comparative Examples 1 to 9 are as shown in Table 10 below.

[0083] [Table 10] [Industrial Applicability]

[0084] The leave-in type bactericidal detergent composition of the present invention has excellent bactericidal activity, is low in irritation to the skin of the hands during use, is easy to spread on the hands immediately after application, is easy to blend in when rubbed in, is non-sticky when drying, leaves a refreshing feeling after drying, and is excellent in stability, and can be suitably used, for example, as a hand disinfectant. In addition, the leave-in type bactericidal detergent composition can also be used on body parts other than the hands. Examples of application sites include hospitals, nursing homes, kitchens, etc., and it can also be suitably used at home.

Claims

1. (A) at least one quaternary ammonium compound selected from benzalkonium chloride, benzethonium chloride, and cetylpyridinium chloride; (B) at least one water-soluble polymer selected from a carboxyvinyl polymer, an alkyl-modified carboxyvinyl polymer, a hydrophobized hydroxypropyl methylcellulose, and a hydroxypropyl cellulose; (C) medium-chain fatty acid glyceryl; (D) at least one basic amino acid selected from arginine, lysine, and histidine and / or a salt thereof; (E) the content of monohydric alcohols having 1 to 3 carbon atoms is less than 10% by mass, A leave-on type bactericidal cleaning agent composition characterized in that the mass ratio [(D) / (C)] of the content (mass%) of the (D) component to the content (mass%) of the (C) component is 0.05 to 0.

33.

2. A leave-in type bactericidal cleaning agent composition as described in claim 1, wherein the content of the (A) component is 0.01% by mass to 0.2% by mass, the content of the (B) component is 0.1% by mass to 0.5% by mass, the content of the (C) component is 0.4% by mass to 0.8% by mass, and the content of the (D) component is 0.1% by mass to 0.3% by mass.

3. A leave-in type bactericidal cleaning composition described in any of claims 1 to 2, further containing (F) 0.05% by mass to 0.5% by mass of at least one surfactant selected from nonionic surfactants, amphoteric surfactants, and semi-polar surfactants.

4. A leave-in type bactericidal detergent composition according to any one of claims 1 to 3, excluding a bactericidal detergent composition containing an alkyl glyceryl ether or alkenyl glyceryl ether having 4 to 12 carbon atoms.

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