Composition for improving stress-induced cognitive dysfunction and medicines, foods, beverages and feeds containing the same

Abstract

To provide a new cognitive function improving composition for preventing or improving a stress-induced decline in cognitive functions, and pharmaceuticals, food and drink, and feed including the same.SOLUTION: A cognitive function improving composition contains a processed agaricus fruiting body.SELECTED DRAWING: Figure 4

Description

[Technical Field]

[0001] The present invention relates to a composition for improving stress-induced cognitive dysfunction, and to a medicine, food, drink, or feed containing the same. [Background technology]

[0002] Dementia is a condition in which cognitive function declines due to causes such as cerebrovascular disorders and degenerative diseases such as Alzheimer's disease, and various research is being conducted on therapeutic drugs to prevent and improve dementia.

[0003] On the other hand, in addition to the causes mentioned above, it is known that mental stress can impair cognitive functions (memory, judgment, calculation, comprehension, learning, thinking, language, etc.).

[0004] Specifically, for example, it is known that loneliness stress increases the risk of developing dementia in the elderly (Non-Patent Document 1), and social isolation is a risk factor for dementia (Non-Patent Document 2). [Prior art documents] [Non-patent literature]

[0005] [Non-Patent Document 1] Wilson et al., Arch. Gen. Psychiatry, 2007 [Non-patent document 2] Livingston et al., The Lancet Commissions, 2017 Summary of the Invention [Problem to be solved by the invention]

[0006] The mechanism behind the stress-related cognitive decline described above is not entirely clear, but it is thought to be a different pathology from senile dementia, which is caused by organic brain damage associated with aging, as cognitive function can sometimes be restored by eliminating the stress factor.

[0007] Therefore, it is thought that it is necessary to consider preventive and improvement measures for stress-related cognitive decline (disorder) that are different from those for senile dementia.

[0008] An object of the present invention is to provide a novel cognitive function-improving composition for preventing or improving stress-induced cognitive decline, and a medicine, food, drink, or feed containing the same. [Means for solving the problem]

[0009] In order to solve the above problems, the following cognitive function-improving compositions, medicines, foods and beverages, and feeds are provided. [1] A cognitive function improving composition for preventing or improving stress-induced cognitive decline, Contains processed Agaricus fruiting body A composition for improving cognitive function. [2] The cognitive function improving composition according to [1], wherein the Agaricus is King·Agaricus 21 strain (accession number: FERM P-17695). [3] The processed material is a dried processed material. The cognitive function improving composition according to [1] or [2] above. [4] A composition for improving cognitive function according to any one of [1] to [3] above. A medicine characterized by: [5] A composition for improving cognitive function according to any one of [1] to [3] above. A food or drink characterized by the above. [6] A composition for improving cognitive function according to any one of [1] to [3] above. A feed characterized by: [Effects of the Invention]

[0010] According to the cognitive function improving composition of the present invention, and the medicine, food, drink and feed containing the same, administration or ingestion of the composition can prevent or improve stress-induced cognitive decline. [Brief explanation of the drawings]

[0011] [Figure 1] This figure shows an overview of the normal diet group (control group), the isolation + normal diet group, and the isolation + agaricus administration group. [Figure 2] This is a graph showing changes in body weight in the normal diet group (control group), the isolation + normal diet group, and the isolation + agaricus administration group. [Figure 3] This graph shows the change in distance traveled in the normal diet group (control group), the isolation + normal diet group, and the isolation + agaricus administration group. Statistical analysis was performed using 2-way ANOVA and Tukey's multiple comparisons test. [Figure 4] This graph shows spatial cognitive function for the normal diet group (control group), the isolation + normal diet group, and the isolation + agaricus administration group. Statistical analysis was performed using 2-way ANOVA and Tukey's multiple comparisons test. DETAILED DESCRIPTION OF THE INVENTION

[0012] The present inventors have discovered a novel finding that agaricus (preferably Agaricus brasiliensis) fruiting bodies have an effect of improving stress-induced cognitive decline, and have completed the present invention.

[0013] One embodiment of the cognitive function-improving composition of the present invention will be described below. The cognitive function-improving composition of the present invention is a composition for improving stress-induced cognitive decline (impairment) (a composition for improving stress-induced cognitive impairment).

[0014] In the present invention, "stress-related cognitive decline" refers to decline in cognitive function (functions such as memory, judgment, calculation, comprehension, learning, thinking, and language) induced by mental stress, for example, due to loneliness, social isolation, or neglect.

[0015] The cognitive function-improving composition of the present invention contains a processed Agaricus blazei mushroom fruiting body.

[0016] Examples of Agaricus fruiting bodies (fruiting bodies of Agaricus blazei Murill, Agaricus brasiliensis, Agaricus subrufescens, etc.) include wild fruiting bodies and fruiting bodies obtained by cultivation.

[0017] Among these, it is preferable that the Agaricus is the King Agaricus 21 strain deposited with the National Institute of Technology and Evaluation under accession number FERM P-17695 (deposit date: January 13, 2000, re-deposit date: July 1, 2016). When the cognitive function improving composition of the present invention contains a processed product of King Agaricus 21 (FERM P-17695), a superior cognitive function improving effect is achieved compared to other Agaricus strains.

[0018] The processed Agaricus fruiting body may be the fruiting body itself or may be any of various processed products obtained by physically, chemically or biologically treating the fruiting body.

[0019] Specifically, examples of physically or chemically treated products include dried products obtained by sun drying, air drying, freeze drying, etc., freeze-dried products, and pulverized products obtained by a blender, homogenizer, ball mill, etc. Biological treatment methods include fermentation methods, etc. Among these, the fruiting bodies are preferably in the form of dried products or freeze-dried products.

[0020] Furthermore, processed products of Agaricus fruiting bodies include extracts obtained from fruiting bodies by various extraction methods, so long as they contain the active ingredients. Examples of extraction methods include various solvent extractions and supercritical fluid extraction. Extracts may also be processed by various solid-liquid separation methods, such as sedimentation, cake filtration, clarification filtration, centrifugal filtration, centrifugal sedimentation, compression separation, and filter presses; various concentration methods; various drying methods; formulation methods, such as granulation or powdering; and various purification methods.

[0021] Furthermore, processed Agaricus fruiting bodies may be added to a solvent such as water to prepare a liquid composition for improving cognitive function.

[0022] The method for producing the cognitive function-improving composition of the present invention includes a step of blending a processed product of Agaricus blazei mushroom fruiting bodies, and may also include various other conventionally known steps.

[0023] The cognitive function-improving composition of the present invention can be in the form of a medicine, food or drink, or feed (or feed additive), and can be administered or ingested by a mammal. That is, the medicine, food or drink, or feed of the present invention contains the above-mentioned cognitive function-improving composition.

[0024] (Pharmaceuticals) The pharmaceutical of the present invention is a pharmaceutical for preventing or improving stress-induced cognitive decline, and includes the cognitive function-improving composition of the present invention described above.

[0025] The pharmaceutical of the present invention may use the cognitive function improving composition of the present invention as an active ingredient as is, or may be formulated by adding pharmaceutically acceptable ingredients.

[0026] The pharmaceutical of the present invention may be in a dosage form for oral administration or a dosage form for parenteral administration. Examples of dosage forms for oral administration include powders, granules, tablets, capsules, elixirs, microcapsules, etc. Examples of dosage forms for parenteral administration include injections, drip infusions, ointments, inhalants, suppositories, etc.

[0027] The medicament of the present invention may contain a pharmaceutically acceptable carrier, such as a known excipient, disintegrant, binder, lubricant, surfactant, buffer, solubilizer, stabilizer, isotonicity agent, suspending agent, emulsifier, solvent, thickener, mucolytic agent, wetting agent, preservative, etc.

[0028] The medicament of the present invention may further contain additives, such as lubricants such as magnesium stearate, sweeteners such as sucrose, lactose, and saccharin, flavorings such as peppermint and rhododendron oil, stabilizers for benzyl alcohol and phenol, buffers such as phosphates and sodium acetate, solubilizers such as benzyl benzoate and benzyl alcohol, antioxidants, and preservatives.

[0029] The pharmaceutical of the present invention can be formulated by appropriately combining the above-mentioned carriers, additives, etc. and mixing them in a unit dose form required for generally accepted pharmaceutical practice.

[0030] The dosage of the pharmaceutical of the present invention varies depending on the patient's weight and age, symptoms of the patient, administration method, etc., but a person skilled in the art can appropriately select an appropriate dosage. The dosage when the cognitive function-improving composition of the present invention is administered to a human varies depending on symptoms, the patient's age, sex, weight, sensitivity difference, administration method, administration interval, type of active ingredient, and type of formulation, and is not particularly limited. For example, when administered or ingested orally, an amount selected from 0.1 mg / kg to 100 g / kg per day can be administered or ingested once or multiple times (e.g., 2 to 5 times, preferably 2 to 3 times).

[0031] Furthermore, the period for administering or taking the pharmaceutical of the present invention is not limited, and for example, the pharmaceutical of the present invention can be administered or taken continuously for a period of one week or more, two weeks or more, one month or more, two months or more, six months or more, one year or more, or longer, in accordance with the dosage and administration described above.

[0032] (food and drink) The food and drink products (foods and beverages) of the present invention are for preventing or improving stress-induced cognitive decline, and include the cognitive function-improving composition of the present invention described above.

[0033] Examples of foods and beverages include health foods and beverages (supplements, dietary supplements, health supplements, nutritionally balanced foods, etc.) in the form of tablets, tablets, chewable tablets, tablets, powders, powders, capsules, granules, drinks, etc., soft drinks, tea drinks, jelly drinks, sports drinks, coffee drinks, carbonated drinks, vegetable drinks, fruit juice drinks, fermented vegetable drinks, fermented fruit juice drinks, fermented milk drinks (yogurt, etc.), lactic acid bacteria drinks, milk drinks, powdered drinks, cocoa drinks, alcoholic drinks, confectionery, jelly, etc. In particular, foods and beverages are preferably in the form of health functional foods (foods for specified health uses, foods with nutrient functions, foods with functional claims) or health foods.

[0034] Furthermore, the "food and drink" of the present invention may contain ingredients commonly used in the field of food engineering. Specific examples include various oils and fats (e.g., vegetable oils such as soybean oil, corn oil, safflower oil, olive oil, etc., and animal oils and fats such as beef tallow and sardine oil), herbal medicines (e.g., royal jelly, ginseng, etc.), amino acids (e.g., glutamine, cysteine, leucine, arginine, etc.), polyhydric alcohols (e.g., ethylene glycol, polyethylene glycol, propylene glycol, glycerin, sugar alcohols such as sorbitol, erythritol, xylitol, maltitol, mannitol, etc.), natural polymers (e.g., gum arabic, agar, water-soluble corn fiber, gelatin, xanthan gum, etc.), and the like. Examples of suitable surfactants include gluten, gluten hydrolysates, lecithin, starch, dextrin, etc.), vitamins (e.g., vitamin C, B vitamins, etc.), minerals (e.g., calcium, magnesium, zinc, iron, etc.), dietary fiber (e.g., mannan, pectin, hemicellulose, etc.), surfactants (e.g., glycerin fatty acid esters, sorbitan fatty acid esters, etc.), purified water, diluents, stabilizers, isotonicity agents, pH adjusters, buffers, humectants, solubilizers, suspending agents, colorants, flavoring agents, odorants, fragrances, antioxidants, sweeteners, taste-providing components, and acidulants.

[0035] The intake amount of the food or drink varies depending on the patient's weight, age, symptoms, administration method, etc., but a person skilled in the art can appropriately select an appropriate dose. Specifically, the intake amount and intake period may be the same as those of the medicament of the present invention.

[0036] (feed) The cognitive function-improving composition of the present invention can be in the form of not only food and drink for humans, but also feed (or feed additives) for livestock, racehorses, pets (such as dogs and cats), and the like.

[0037] The dosage or intake of the medicine and food and drink of the present invention can be adjusted as appropriate, taking into consideration the age and body weight of the subject, the route of administration, the number of times of administration or intake, etc.

[0038] The cognitive function-improving composition, medicament, and food and drink of the present invention are not limited to the above embodiments. Note that, since the cognitive function-improving composition, medicament, food and drink, and feed of the present invention contain processed Agaricus fruiting bodies, they may also achieve conventionally known medicinal effects such as strengthening and improving the liver, heart, gastrointestinal tract, stabilizing blood pressure and blood sugar levels, relieving lower back pain and stiff shoulders, improving hair loss and graying, preventing aging, improving immunity, antitumor activity, reducing the side effects of anticancer drugs, and wound healing effects. [Example]

[0039] The cognitive function improving composition of the present invention will be described in detail below with reference to examples, but the cognitive function improving composition of the present invention is not limited to the following examples in any way.

[0040] <1> Agaricus fruiting body The dried fruiting bodies used were Agaricus brasiliensis KA21, cultivated outdoors in Brazil. This strain has been deposited at the National Institute of Technology and Evaluation (NIET) (accession number: FERM P-17695 King·Agaricus 21).

[0041] <2> Feeding mice Four-week-old mice were divided into a normal diet group (control group), an isolation + normal diet group, and an isolation + agaricus administration group (Figure 1).

[0042] Specifically, the normal diet group (control group) was fed a normal diet for 8 weeks without any stress such as isolation. The isolation + normal diet group was fed a normal diet for 8 weeks while group-housed mice were housed in isolation (social isolation) and under stress. The isolation + Agaricus treatment group was fed a normal diet plus dried Agaricus fruiting body (King·Agaricus 21) powder (5% by mass of the normal diet) for 8 weeks while under social isolation and under stress.

[0043] <3> Measurement of weight and distance traveled Body weight and distance traveled were measured for the normal diet group (control group), the isolation + normal diet group, and the isolation + agaricus administration group. No significant differences were observed in body weight among the normal diet group (control group), the isolation + normal diet group, and the isolation + agaricus administration group (Figure 2). Furthermore, no significant differences were observed in distance traveled among the normal diet group (control group), the isolation + normal diet group, and the isolation + agaricus administration group (Figure 3).

[0044] <4> Cognitive function assessment test To evaluate the spatial cognitive function of mice in each group, we performed the Y-maze test (Figure 4). The Y-maze test utilizes the tendency of mice to spontaneously enter different arms during exploratory behavior, allowing us to evaluate alternation responses as an index of spatial working memory (see, for example, Saito et al., Nat. Neurosci, 2014).

[0045] The results showed that cognitive function declined in the isolation + normal diet group due to the stress associated with isolation. In contrast, no decline in cognitive function due to the stress associated with isolation was observed in the isolation + agaricus administration group. In other words, it was confirmed that administration of agaricus can prevent or improve stress-induced cognitive decline.

Claims

1. A cognitive function improving composition for preventing or improving stress-related cognitive decline, Contains dried or freeze-dried Agaricus fruiting bodies, The Agaricus is King Agaricus strain 21 (accession number: FERM P-17695). A composition for improving cognitive function.

2. A composition for improving cognitive function according to claim 1, A medicine for preventing and improving stress-related cognitive decline.

3. A composition for improving cognitive function according to claim 1, Food and drink for preventing and improving stress-related cognitive decline.

4. A composition for improving cognitive function according to claim 1, Feed for preventing and improving stress-induced cognitive decline.

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