Antimicrobial combination compositions comprising glycerol derivatives and bicyclic compounds

Abstract

To provide antimicrobial combination compositions that can be used in cosmetic formulations.SOLUTION: A cosmetic composition comprises (a) glycerol derivatives selected from the group consisting of 3-[(2-ethylhexyl)oxy]-1,2-propanediol, 3-[(n-octyl)oxy]-1,2-propanediol, and 3-[(2-octyl)oxy]-1,2-propanediol, and (b) bicyclic compounds selected from the group consisting of 5,7-dihydroxy-2-(4-hydroxyphenyl)chroman-4-one (naringenin), 2-(3,4-dihydroxyphenyl)-3,5,7-trihydroxychromen-4-one (quercetin), 5,7-dihydroxy-2-(3-hydroxy-4-methoxyphenyl)chroman-4-one (hesperetin), and 5,7-dihydroxy-2-(3,4-dihydroxyphenyl)-chroman-4-one (eriodyctiol).SELECTED DRAWING: None

Description

[Technical Field]

[0001] The present disclosure relates, inter alia, to antimicrobial combination compositions comprising: (a) one or more glycerol derivatives; and (b) one or more bicyclic compounds. The antimicrobial combination compositions can be used in cosmetic or pharmaceutical formulations. [Background technology]

[0002] Preserving household preparations, such as cosmetic preparations, extends their shelf life and therefore provides consumers with greater value for money. Furthermore, preservatives prevent consumers from spreading microorganisms around their homes or to themselves, thus providing health benefits. Antimicrobial active substances have been well described in the art, and many are available that offer excellent performance.

[0003] Pesaro et al., in WO2014191258A2 (Symrise) (Patent Document 1), relates to antimicrobial compositions containing glyceryl ethers. Pesaro et al. discloses octylglycerin in paragraphs 0024 and 00234. [Prior art documents] [Patent documents]

[0004] [Patent Document 1] WO2014191258A2 Summary of the Invention [Problem to be solved by the invention]

[0005] In a first aspect, the present invention relates to an antimicrobial combination composition comprising, inter alia: (a) one or more glycerol derivatives selected from the group consisting of 3-[(2-ethylhexyl)oxy]-1,2-propanediol, 3-[(n-octyl)oxy]-1,2-propanediol, and 3-[(2-octyl)oxy]-1,2-propanediol; and (b) one or more bicyclic compounds selected from the group consisting of 5,7-dihydroxy-2-(4-hydroxyphenyl)chroman-4-one (naringenin), 2-(3,4-dihydroxyphenyl)-3,5,7-trihydroxychromen-4-one (quercetin), 5,7-dihydroxy-2-(3-hydroxy-4-methoxyphenyl)chroman-4-one (hesperetin), and 5,7-dihydroxy-2-(3,4-dihydroxyphenyl)-chroman-4-one (eriodictyol).

[0006] A second aspect relates to the antimicrobial combination composition of the first aspect for use as a medicament. Another embodiment of the second aspect relates to the antimicrobial agent of the first aspect for use in (prophylactically) treating an infection in the human or animal body.

[0007] A third aspect relates to a cosmetic composition comprising an antimicrobial combination composition according to the first aspect; specifically, the third aspect relates to a cosmetic composition comprising: (a) one or more glycerol derivatives selected from the group consisting of 3-[(2-ethylhexyl)oxy]-1,2-propanediol, 3-[(n-octyl)oxy]-1,2-propanediol, and 3-[(2-octyl)oxy]-1,2-propanediol; and (b) one or more bicyclic compounds selected from the group consisting of 5,7-dihydroxy-2-(4-hydroxyphenyl)chroman-4-one (naringenin), 2-(3,4-dihydroxyphenyl)-3,5,7-trihydroxychromen-4-one (quercetin), 5,7-dihydroxy-2-(3-hydroxy-4-methoxyphenyl)chroman-4-one (hesperetin), and 5,7-dihydroxy-2-(3,4-dihydroxyphenyl)-chroman-4-one (eriodictyol).

[0008] In a particular embodiment, the cosmetic composition is for leave-on skin care use and has a pH in the range of 4-6.

[0009] A fourth aspect relates to a care method for keratinous materials, comprising: (1) applying a cosmetic composition according to the third aspect or an antimicrobial composition according to the first aspect onto a keratin material; and (2) leaving the composition on the keratinous material for at least 1 hour;

[0010] A fifth aspect relates to the use of the antimicrobial combination composition of the first aspect in the preservation of a cosmetic composition. [Means for solving the problem]

[0011] Definitions and General As used herein, including in all embodiments of all aspects of the present invention, the following definitions apply unless otherwise specified: All percentages are by weight (w / w) of the total composition. All ratios are by weight. "wt%" means percent by weight. Reference to "parts," e.g., a mixture of 1 part X and 3 parts Y, is a ratio by weight. "QS" or "QSP" means 100% or an amount sufficient for 100 g. + / - indicates standard deviation. All ranges are inclusive and combinable. The number of significant digits does not impose a limitation on the stated amount or the precision of the measurements. All numerical amounts are understood to be modified by the word "about." All measurements are understood to be made at 23°C and ambient conditions, where "ambient conditions" means under a pressure of 1 atmosphere (atm) and a relative humidity of 50%. "Relative humidity" refers to the ratio of the moisture content of air (expressed as a percentage) compared to the saturation moisture level at the same temperature and pressure. Relative humidity can be measured using a hygrometer, particularly a probe hygrometer from VWR® International. As used herein, "min" means "minute" or "minutes." As used herein, "mol" means mole. As used herein, "g" following a number means "gram" or "grams." "Ex." means "example." All amounts, when they pertain to listed ingredients, are based on the active level ("solids") and do not include carriers or by-products that may be included in commercially available materials. As used herein, "comprising" means that other steps and other ingredients can be added. "Comprising" encompasses the phrases "consisting of" and "consisting essentially of."The compositions, formulations, methods, uses, kits, and methods of the present invention can comprise, consist of, or consist essentially of the inventive elements and limitations described herein, as well as any additional or optional ingredients, components, steps, or limitations described herein. The embodiments and aspects described herein may include or be combinable with elements, features, or components of other embodiments and / or aspects, even if not explicitly exemplified in combination, unless an incompatibility is noted. "In certain embodiments" means that one or more embodiments of the present invention, optionally all embodiments or a larger subset of embodiments, have the subsequently described characteristics. When amount ranges are given, they should be understood to refer to the total amount of the ingredient in the composition, or, if more than one species falls within an ingredient definition, to the total amount of all ingredients meeting that definition in the composition. For example, if a composition contains 1%-5% fatty alcohols, a composition containing 2% stearyl alcohol and 1% cetyl alcohol but no other fatty alcohols would fall within this range.

[0012] "Independently selected from" means that the referenced groups can be the same, different, or a mixture thereof, unless the context clearly dictates otherwise. Thus, in this definition, the phrase "X1, X2, and X3 are independently selected from noble gases" includes scenarios where X1, X2, and X3 are all the same, where X1, X2, and X3 are all different, and where X1 and X2 are the same but X3 is different.

[0013] "Molecular weight" or "M.Wt." or "MW" and grammatical equivalents means number average molecular weight.

[0014] "Viscosity" is 12.9s -1at a shear rate of 1000 rpm and at 25°C using a HAAKE Rotation Viscometer VT 550 with a cooling / heating vessel and sensor system according to DIN 53019.

[0015] "Water-soluble" refers to any substance that is sufficiently soluble in water to form a solution that is clear to the naked eye at a concentration of 0.1% by weight of the substance in water at 25° C. The phrase "water-insoluble" refers to any substance that is not "water-soluble."

[0016] "Dry" or "substantially dry" means containing less than 5%, less than 3%, or less than 2%, less than 1%, or about 0% of any compound or composition in liquid form when measured at 25°C under ambient conditions. Such compounds or compositions in liquid form include water, oils, organic solvents, and other humectants. "Anhydrous" means that the composition contains less than 5%, less than 3%, or less than 2%, less than 1%, or about 0% water, based on the total weight of the composition.

[0017] "Substantially free from" or "substantially free of" means less than 1%, or less than 0.8%, or less than 0.5%, or less than 0.3%, or about 0% by weight of the total composition or formulation.

[0018] "Hair" refers to mammalian keratinous fibers, including scalp, facial, and body hair. This includes hair as still growing on a living subject, as well as hair that has fallen from a subject, such as hair swatches and doll / mannequin hair. In certain embodiments, "hair" refers to human hair. "Hair shaft" or "hair fiber" refers to an individual hair and can be used interchangeably with the term "hair."

[0019] "Proximal to the scalp" refers to a portion of an elongated or substantially straight hair shaft that is closer to the scalp than the ends of the hair. Thus, about 50% of the length of a hair fiber is considered to be proximal to the scalp, and about 50% of the hair fiber is considered to be distal to the scalp. "z cm proximal to the scalp" refers to a distance "z" along a hair, having one endpoint on or immediately adjacent to the scalp, and a second endpoint that is "z" centimeters measured along the length of an elongated or substantially straight hair.

[0020] "Chemically modified" or its grammatical equivalents means that one chemical moiety, e.g., a monomer and / or crosslinker and / or polymer, is stably attached to a second chemical moiety, e.g., a keratin protein, another component of hair, and / or another monomer or crosslinker or polymer. Typically, "chemically modified" means stably attached via a covalent bond, unless otherwise specified. "Cosmetically acceptable" means that the described composition, formulation, or ingredients are suitable for use in contact with human keratinous tissue without undue toxicity, incompatibility, instability, allergic reaction, etc. All compositions and formulations described herein intended for direct application to keratinous tissue are limited to being cosmetically acceptable.

[0021] "Derivatives" include, but are not limited to, amide, ether, ester, amino, carboxyl, acetyl, acid, salt, and / or alcohol derivatives of a given compound. In certain embodiments, "derivatives thereof" refers to amide, ether, ester, amino, carboxyl, acetyl, acid, salt, and alcohol derivatives.

[0022] "Monomer" means a discrete, unpolymerized chemical moiety that can undergo polymerization in the presence of an initiator, or any suitable reaction to produce a macromolecule (e.g., polycondensation, polyaddition, anionic or cationic polymerization). "Unit" means a monomer that has already been polymerized, i.e., is part of a polymer.

[0023] "Polymer" means a chemical substance formed from the polymerization of two or more monomers. The term "polymer" includes all materials made by the polymerization of monomers as well as natural polymers.

[0024] A polymer made from only one type of monomer is called a homopolymer. As used herein, a polymer comprises at least two monomers. A polymer made from two or more different types of monomers is called a copolymer. The distribution of the different monomers can be random, alternating, or block-like (i.e., block copolymer). As used herein, the term "polymer" includes any type of polymer, including homopolymers and copolymers.

[0025] "Kit" refers to a package containing multiple components. A "kit" may also be referred to as a "kit-of-parts." An example of a kit is, for example, a first composition and a separately packaged second composition and, optionally, instructions for use.

[0026] Details of the invention and its embodiments are provided below.

[0027] First Aspect A first aspect relates to an antimicrobial combination. As described above, the antimicrobial combination composition comprises (a) one or more glycerol derivatives and (b) one or more bicyclic compounds.

[0028] As described above, the antimicrobial composition comprises one or more glycerol derivatives. In certain embodiments of the present disclosure, the glycerol derivatives are selected from the group consisting of 3-[(2-ethylhexyl)oxy]-1,2-propanediol, 3-[(n-octyl)oxy]-1,2-propanediol, and 3-[(2-octyl)oxy]-1,2-propanediol. In certain embodiments, the glycerol derivatives are selected from the group consisting of 3-[(n-octyl)oxy]-1,2-propanediol and 3-[(2-octyl)oxy]-1,2-propanediol. In certain embodiments, the one or more glycerol derivatives are 3-[(n-octyl)oxy]-1,2-propanediol and 3-[(2-octyl)oxy]-1,2-propanediol. In certain embodiments, the one or more glycerol derivatives are 3-[(n-octyl)oxy]-1,2-propanediol. In certain embodiments, the one or more glycerol derivatives are 3-[(2-octyl)oxy]-1,2-propanediol. In certain embodiments, the one or more glycerol derivatives are 3-[(2-ethylhexyl)oxy]-1,2-propanediol.

[0029] In certain embodiments, the glycerol derivative may be selected from the compounds of formula (I) provided in International Publication WO2018 / 125734, the entire contents of which are incorporated herein by reference.

[0030] In certain embodiments, the antimicrobial combination composition is a concentrate (i.e., at a concentration suitable for further dilution before final use), hi certain embodiments, the antimicrobial combination composition is a working mixture (i.e., at a concentration suitable for final use).

[0031] The glycerol derivatives of the present disclosure are preferably provided with a purity of at least 92% prior to their incorporation into the antimicrobial combination composition. In certain embodiments, the glycerol derivatives of the present disclosure are provided with a purity of at least 99.99%, or at least 99.90%, or at least 99%, or at least 98%, or at least 94% prior to their incorporation into the antimicrobial combination composition. In certain embodiments, the glycerol derivatives of the present disclosure are provided with a purity of at least 99.99% prior to their incorporation into the antimicrobial combination composition. These purity levels of one or more glycerol derivatives ensure that the composition contains little, if any, impurities that may be ingested or absorbed (e.g., through the skin) by a subject using the antimicrobial combination composition of the present disclosure as a concentrate (or the resulting cosmetic or pharmaceutical preparation containing the antimicrobial combination composition of the present disclosure) or as a use mixture.

[0032] As described above, the antimicrobial combination composition comprises one or more bicyclic compounds. In certain embodiments of the present disclosure, the bicyclic compounds are selected from the group consisting of 5,7-dihydroxy-2-(4-hydroxyphenyl)chroman-4-one (naringenin), 2-(3,4-dihydroxyphenyl)-3,5,7-trihydroxychromen-4-one (quercetin), 5,7-dihydroxy-2-(3-hydroxy-4-methoxyphenyl)chroman-4-one (hesperetin), and 5,7-dihydroxy-2-(3,4-dihydroxyphenyl)-chroman-4-one (eriodictyol). In certain embodiments, the one or more bicyclic compounds are naringenin. In certain embodiments, the one or more bicyclic compounds are quercetin. In certain embodiments, the one or more bicyclic compounds are hesperetin. In certain embodiments, the one or more bicyclic compounds is eriodictyol.

[0033] In certain embodiments, the bicyclic compound may be selected from compounds of formula (II) provided in International Publication WO2018 / 125734, the entire contents of which are incorporated herein by reference.

[0034] The bicyclic compound of the present disclosure can be provided with a purity of at least 85% before being incorporated into the antimicrobial combination composition, for example. In certain embodiments, the bicyclic compound of the present disclosure is provided with a purity of at least 99.99%, or at least 99.90%, or at least 99%, or at least 98%, or at least 94%, or at least 92%, or at least 90%, or at least 89%, or at least 87% before being incorporated into the antimicrobial combination composition. In certain embodiments, the bicyclic compound of the present disclosure is provided with a purity of at least 99.99% before being incorporated into the antimicrobial combination composition. As described above with respect to glycerol derivatives, these levels of purity of the bicyclic compound ensure that the antimicrobial combination composition of the present disclosure is safe for consumers.

[0035] In certain embodiments, the one or more bicyclic compounds are present in an amount ranging from about 50 ppm to about 50,000 ppm (corresponding to 0.005% to 5% by weight), based on the total weight of the one or more glycerol derivatives. Thus, using this embodiment as an example, about 50 ppm to about 50,000 ppm of the one or more bicyclic compounds are added to an otherwise substantially pure antimicrobial combination composition (e.g., an antimicrobial concentrate) containing a glycerol derivative. In certain embodiments, the one or more bicyclic compounds are present in an amount ranging from about 100 ppm to about 10,000 ppm, or from about 200 ppm to about 5,000 ppm, or from about 500 ppm to about 1,000 ppm, or from about 300 ppm to about 900 ppm, based on the total weight of the one or more glycerol derivatives.

[0036] In certain embodiments, the one or more bicyclic compounds are present in an amount of less than 5% by weight, or less than 3% by weight, or less than 1% by weight, or even less than 0.5% by weight, hi certain embodiments, the one or more bicyclic compounds are naringenin (5,7-dihydroxy-2-(4-hydroxyphenyl)chroman-4-one) and are present in an amount of less than 5% by weight, or less than 3% by weight, or less than 1% by weight, or even less than 0.5% by weight, based on the total weight of the one or more glycerol derivatives.

[0037] When the antimicrobial combination composition of the present disclosure is provided as a concentrate for further use in a cosmetic or pharmaceutical formulation, the antimicrobial combination composition may be further diluted (e.g., by adding it to another solution), nevertheless leaving the amount of one or more bicyclic compounds as described above relative to the amount of one or more glycerol derivatives. Optionally, it may be desirable to add an additional amount of the one or more bicyclic compounds to the cosmetic or pharmaceutical formulation as an additional antioxidant for the cosmetic or pharmaceutical formulation.

[0038] In one embodiment, the antimicrobial combination composition is a concentrate containing 0.01% to 5% by weight of one or more bicyclic compounds, based on the total weight of the one or more glycerol derivatives. In one embodiment, the antimicrobial combination composition is a concentrate containing any of the above amounts of one or more bicyclic compounds, based on the total weight of the one or more glycerol derivatives. In another embodiment, the concentrate contains one or more other ingredients, as described below.

[0039] In certain embodiments, the antimicrobial combination compositions of the present disclosure are in the form of a use mixture (i.e., at a concentration suitable for end use). The use mixture may contain up to about 60% by weight (e.g., 10% to about 60% by weight) of the antimicrobial combination composition defined herein. To obtain such a use mixture, the antimicrobial combination composition described herein can be dissolved in (i.e., diluted with) an appropriate amount of an additive (e.g., a diluent or excipient). For example, in certain embodiments, the antimicrobial combination composition can be diluted in water, alcohol(s), polyol(s), or a mixture thereof to obtain a use mixture. In such a use mixture, even after dilution of the antimicrobial combination composition, the amount of one or more bicyclic compounds as described above remains relative to the amount of one or more glycerol derivatives. Optionally, it may be desirable to add an additional amount of one or more bicyclic compounds to the use mixture.

[0040] The antimicrobial combination composition of the present disclosure described herein, whether in the form of concentrate or as a mixture for use, can be added to cosmetic and / or pharmaceutical preparations, for example, as seen from the use of glycerol derivatives, such as glycerol monoalkyl ether.In other embodiments, the antimicrobial combination composition described herein is intended to be provided with glycerol derivatives and can be used in industrial products where peroxides are undesirable, such as preparations containing dyes or fragrances, or containing compounds that are unsaturated or sensitive to oxidation.Such formulations or industrial products can include, for example, deodorants, skin care products, sunscreens, baby products, cosmetics, aftershave products, disinfectants, antiseptics, cleansing lotions, shower lotions, and hair treatment compositions (for example, leave-in or rinse-out compositions). Thus, in certain embodiments, the antimicrobial combination compositions are completely free or substantially free of one or more peroxides (e.g., less than 1000 ppm, or less than 100 ppm, or less than 10 ppm, or even less than 1 ppm of peroxide(s) present in the antimicrobial combination compositions of the present disclosure as described elsewhere herein).

[0041] In an exemplary embodiment of the first aspect, the present disclosure provides an antimicrobial combination composition, as described herein, whether added as a concentrate or as a use mixture, used in a preparation such as the above examples, such that the corresponding cosmetic, pharmaceutical, or industrial preparation contains about 0.05 to about 5 wt. % of one or more glycerol derivatives as defined herein, or in another embodiment about 0.1 to about 1 wt. %, or in another embodiment about 0.2 to about 0.6 wt. %, or in other embodiments 0.3 wt. % or 0.5 wt. % of one or more glycerol derivatives. It should be noted that, prior to distillation, as the purity of the one or more glycerol derivative compounds increases, e.g., from 94% to 98% purity, somewhat higher amounts of one or more bicyclic compounds may be required. Without being bound by theory, it is believed that higher purity glycerol derivatives may require greater stabilization.

[0042] Second Aspect The second aspect relates to an antimicrobial combination composition as described elsewhere herein (e.g., of the first aspect) for use as a pharmaceutical. Another embodiment of the second aspect relates to an antimicrobial combination composition as described elsewhere herein (e.g., of the first aspect) for use in treating (prophylactically) an infection in the human or animal body.

[0043] Third Aspect A third aspect relates to a cosmetic composition comprising an antimicrobial combination composition (e.g., of the first aspect) as described elsewhere herein. Specifically, the third aspect relates to a cosmetic composition comprising: (a) one or more glycerol derivatives selected from the group consisting of 3-[(2-ethylhexyl)oxy]-1,2-propanediol, 3-[(n-octyl)oxy]-1,2-propanediol, and 3-[(2-octyl)oxy]-1,2-propanediol; and (b) one or more bicyclic compounds selected from the group consisting of 5,7-dihydroxy-2-(4-hydroxyphenyl)chroman-4-one (naringenin), 2-(3,4-dihydroxyphenyl)-3,5,7-trihydroxychromen-4-one (quercetin), 5,7-dihydroxy-2-(3-hydroxy-4-methoxyphenyl)chroman-4-one (hesperetin), and 5,7-dihydroxy-2-(3,4-dihydroxyphenyl)-chroman-4-one (eriodictyol).

[0044] The cosmetic compositions of the present disclosure described herein can be advantageously used even when they have a low pH. For example, in certain embodiments, the cosmetic compositions have a pH value ranging from 2.0 to 7.0, or from 3.0 to 7.0, or from 4.5 to 7.0, or from 4 to 6.5, or from 4 to 6, or from 4.5 to 6.5, or from 4.5 to 6, or from 5.3 to 5.7, or from 5 to 6, or a pH of about 5.5. By changing the pH value, cosmetic compositions suitable for different uses can be used.

[0045] In certain embodiments, the cosmetic compositions described elsewhere herein are for leave-on skin care use and have a pH in the range of 4-6.

[0046] As noted above, the cosmetic compositions of the present disclosure, as described elsewhere herein, in certain embodiments, comprise an antimicrobial combination composition, as described elsewhere herein (e.g., according to the first aspect), in an amount of up to about 60% by weight, based on the total weight of the cosmetic composition. For example, in certain embodiments, the cosmetic composition of the present disclosure comprises, based on the total weight of the cosmetic composition, from 1 wt % to about 60 wt % of the antimicrobial combination composition, or alternatively, from 10 wt % to 60 wt %, or from 20 wt % to 60 wt %, or from 30 wt % to 60 wt %, or from 40 wt % to 60 wt %, or from 50 wt % to 60 wt %, or from 1 wt % to 40 wt %, or from 10 wt % to 40 wt %, or from 20 wt % to 40 wt %, or from 30 wt % to 40 wt %, or from 1 wt % to 30 wt %, or from 10 wt % to 30 wt %, or from 20 wt % to 30 wt %, or from 1 wt % to 20 wt %, or from 10 wt % to 20 wt %, or from 1 wt % to 15 wt %, or from 1 wt % to 10 wt %, or from 1 wt % to 5 wt % of the antimicrobial combination composition.

[0047] The amount of one or more glycerol derivatives present in the cosmetic composition is in the range of about 0.0005% to about 5% by weight. For example, in certain embodiments, the one or more glycerol derivatives are present in an amount of from about 0.001 wt % to about 5 wt %, or from about 0.01 wt % to about 5 wt %, or from about 0.1 wt % to about 5 wt %, or from about 1 wt % to about 5 wt %, or from 0.0005 wt % to about 1 wt %, or from about 0.001 wt % to about 1 wt %, or from about 0.01 wt % to about 1 wt %, or from about 0.1 wt % to about 1 wt %, or from about 0.5 wt % to about 1 wt %, or from 0.0005 wt % to about 0.5 wt %, or from about 0.001 wt % to about 0.5 wt %, or from about 0.01 wt % to about 0.5 wt %, or from about 0.1 wt % to about 0.5 wt %, or from about 0.5 wt % to about 0.5 wt %, based on the total weight of the cosmetic composition. %, or 0.0005% to about 0.1% by weight, or about 0.001% to about 0.1% by weight, or about 0.01% to about 0.1% by weight, or about 0.05% to about 5% by weight, or about 0.1% to about 1% by weight, or about 0.1% to about 0.6% by weight, or about 0.1% to about 0.5% by weight, or about 0.1% to about 0.4% by weight, or about 0.2% to about 1% by weight, or about 0.2% to about 0.6% by weight, or about 0.2% to about 0.5% by weight, or about 0.2% to about 0.4% by weight, or about 0.4% to about 1% by weight, or about 0.4% to about 0.6% by weight, or about 0.4% to about 0.5% by weight, or about 0.3% by weight, or about 0.5% by weight.

[0048] The amount of one or more bicyclic compounds in the cosmetic composition is in the range of about 50 ppm to about 50,000 ppm (corresponding to 0.005 wt.% to 5 wt.%), based on the total weight of one or more glycerol derivatives present in the cosmetic composition. In certain embodiments, the amount of one or more bicyclic compounds is in the range of about 100 ppm to about 10,000 ppm, or about 200 ppm to about 5,000 ppm, or about 500 ppm to about 1,000 ppm, or about 300 ppm to about 900 ppm, based on the total weight of one or more glycerol derivatives present in the cosmetic composition. In certain embodiments, the cosmetic composition of the present disclosure can contain an additional amount of one or more bicyclic compounds (i.e., in addition to those provided for the antimicrobial combination composition).

[0049] In certain embodiments, the one or more bicyclic compounds are present in an amount of less than 5% by weight, or less than 3% by weight, or less than 1% by weight, or even less than 0.5% by weight, hi certain embodiments, the one or more bicyclic compounds are naringenin (5,7-dihydroxy-2-(4-hydroxyphenyl)chroman-4-one) and are present in an amount of less than 5% by weight, or less than 3% by weight, or less than 1% by weight, or even less than 0.5% by weight, based on the total weight of the one or more glycerol derivatives.

[0050] In certain embodiments, the cosmetic composition of the present disclosure described herein can further comprise one or more additives selected from surfactants and adjuvants.Suitable surfactants and adjuvants are described in more detail below.In certain embodiments, the one or more additives described above are acceptable for cosmetic use (i.e., cosmetically acceptable).

[0051] surfactants In certain embodiments, the cosmetic compositions of the present disclosure, as described elsewhere herein, comprise one or more surfactants. In certain embodiments, the cosmetic compositions described elsewhere herein comprise a surfactant system comprising a plurality of different surfactants. In certain embodiments, the surfactant system comprises a surfactant selected from the group consisting of anionic surfactants, cationic surfactants, nonionic surfactants, zwitterionic surfactants, and / or amphoteric surfactants. In certain embodiments, the surfactant is selected from the group consisting of anionic surfactants, cationic surfactants, nonionic surfactants, zwitterionic surfactants, and / or amphoteric surfactants.

[0052] In certain embodiments, the cosmetic composition comprises a total amount of surfactants of 0.01% to 70% by weight, 0.1% to 40% by weight, 1% to 30% by weight, or 2% to 20% by weight.

[0053] In certain embodiments, the cosmetic composition described elsewhere herein comprises an anionic surfactant. In certain embodiments, the cosmetic composition comprises an anionic surfactant as the cosmetically acceptable component (II). In certain embodiments, the anionic surfactant is (C 10 -C 20)-alkyl and alkylene carboxylates, alkyl ether carboxylates, fatty alcohol sulfates, fatty alcohol ether sulfates, alkylamide sulfates and sulfonates, fatty acid alkylamide polyglycol ether sulfates, alkane sulfonates and hydroxyalkane sulfonates, olefin sulfonates, acyl esters of isethionates, α-sulfofatty acid esters, alkylbenzene sulfonates, alkylphenol glycol ether sulfonates, sulfosuccinates, sulfosuccinic acid monoesters and diesters, fatty alcohol ether phosphates, protein / fatty acid condensation products, alkyl monoglyceride sulfates and sulfonates, alkyl glyceride ether sulfonates, fatty acid methyl taurides, fatty acid sarcosinates, sulforicinoleates, acyl glutamates, and mixtures thereof. The anionic surfactants (and mixtures thereof) can be used in the form of their water-soluble or water-dispersible salts, examples of which include sodium, potassium, magnesium, ammonium, mono-, di-, and triethanolammonium, and similar alkylammonium salts. In certain embodiments, the anionic surfactant is a salt of an anionic surfactant containing 12 to 14 carbon atoms. In certain embodiments, the anionic surfactant is selected from the group consisting of sodium lauryl sulfate, sodium laureth sulfate, sodium tridecyl sulfate, sodium trideceth sulfate, sodium myristyl sulfate, sodium myreth sulfate, and mixtures thereof. Typical anionic surfactants for use in the compositions of the present invention include sodium oleyl succinate, ammonium lauryl sulfosuccinate, sodium lauryl sulfate, sodium lauryl ether sulfate, sodium lauryl ether sulfosuccinate, ammonium lauryl sulfate, ammonium lauryl ether sulfate, sodium dodecylbenzenesulfonate, triethanolamine dodecylbenzenesulfonate, sodium cocoyl isethionate, sodium lauryl isethionate, sodium lauryl ether carboxylate, and sodium N-lauryl sarcosinate.Preferred anionic surfactants are selected from sodium lauryl sulfate and sodium lauryl ether sulfate (n)EO (n=1-3); more preferably sodium lauryl ether sulfate (n)EO (n=1-3); most preferably sodium lauryl ether sulfate (n)EO (n=1). Preferably, the level of alkyl ether sulfate is from 0.5% to 25% by weight of the total composition, more preferably from 3% to 18% by weight of the total composition, most preferably from 6% to 15% by weight.

[0054] The total amount of anionic surfactant in the composition may range from 0.5% to 45% by weight, more preferably from 1.5% to 20% by weight.

[0055] In certain embodiments, the cosmetic compositions described elsewhere herein comprise fatty acyl isethionates. In certain embodiments, the cosmetic compositions comprise fatty acyl isethionates at levels of 1% to 10% by weight, more preferably 2% to 8% by weight, and most preferably 2.5% to 7.5% by weight. Preferred fatty acyl isethionate products comprise fatty acyl isethionate surfactants at levels of 40-80% by weight of the product, and free fatty acids and / or fatty acid salts at levels of 15-50% by weight. Preferably, greater than 20% and less than 45% by weight, more preferably greater than 25% and less than 45% by weight, of the fatty acyl isethionates are of C6 or higher chain length; greater than 50% by weight, preferably greater than 60% by weight, of the free fatty acids / soaps are C6-C 20Furthermore, the composition may contain isethionate salts, typically present at levels less than 5% by weight, and trace amounts (less than 2% by weight) of other impurities. Preferably, a mixture of fatty fatty acids is used to prepare the commercially available fatty acyl isethionate surfactants. The resulting fatty acyl isethionate surfactant (e.g., obtained from the reaction of an alkali metal isethionate with an aliphatic fatty acid) preferably has more than 20% by weight, preferably more than 25% by weight, but not more than 45% by weight, preferably not more than 35% by weight (based on the fatty acyl isethionate reaction product), of fatty acyl groups having 16 or more carbon atoms, which should impart both excellent lathering and skin gentleness to the resulting fatty acyl isethionate product. These long-chain fatty acyl isethionate surfactants and fatty acids, i.e., fatty acyl groups and fatty acids having 16 or more carbon atoms, are typically capable of forming insoluble surfactant / fatty acid crystals in water at ambient temperature.

[0056] In certain embodiments, the cosmetic compositions described elsewhere herein comprise an acylglycinate surfactant. In certain embodiments, the acylglycinate surfactant conforms to formula (Y):

[0057] [ka] During the ceremony, R 1a is a linear or branched saturated alkanoyl group having 6 to 30, preferably 8 to 22, particularly preferably 8 to 18 carbon atoms, or a linear or branched mono- or polyunsaturated alkenoyl group having 6 to 30, preferably 8 to 22, particularly preferably 12 to 18 carbon atoms, and Q is a + is a cation. In certain embodiments, Q a + Li + , Na + , K. + , Mg ++ , Ca ++ , Al +++ , NH4+ , monoalkylammonium ions, dialkylammonium ions, trialkylammonium ions and tetraalkylammonium ions, or combinations thereof.

[0058] Optionally, R 1a are independent of each other, (C1-C 22 )-alkyl group or (C2-C 10 In certain embodiments, the acyl glycinate surfactant is selected from sodium cocoyl glycinate and potassium cocoyl glycinate. In certain embodiments, the acyl glycinate surfactant is selected from those where R is C 12 Alkyl or C 14 In certain embodiments, the acyl glycinate surfactant is selected from those according to formula (Y) where R is C 16 Alkyl or C 18 is selected from those according to formula (Y):

[0059] In certain embodiments, the cosmetic compositions described elsewhere herein comprise from 0.01% to 30%, or from 1% to 25%, preferably from 5% to 20%, and more preferably from 12% to 18% by weight of an acylglycinate surfactant.

[0060] In certain embodiments, the cosmetic compositions described elsewhere herein comprise a glutamate surfactant or salt thereof corresponding to formula (Z):

[0061] [ka] During the ceremony, R' is HOOC-CH2-CH2- or M +- OOC-CH2-CH2-, M + is a cation; and R is a linear or branched saturated alkanoyl group having 6 to 30, preferably 8 to 22, more preferably 8 to 18 carbon atoms, or a linear or branched mono- or polyunsaturated alkenoyl group having 6 to 30, preferably 8 to 22, more preferably 12 to 18 carbon atoms. In certain embodiments, M + is a metal cation. In certain embodiments, M + Li +、 Na +、 K +、 Mg ++、 Ca ++ , Al +++、 NH4 + , monoalkylammonium ions, dialkylammonium ions, trialkylammonium ions, and tetraalkylammonium ions, or combinations thereof. In certain embodiments, the glutamate surfactant is selected from sodium cocoyl glutamate and potassium cocoyl glutamate. In certain embodiments, the glutamate surfactant is selected from the group consisting of sodium cocoyl glutamate and potassium cocoyl glutamate. In certain embodiments, the glutamate surfactant is selected from the group consisting of sodium cocoyl glutamate and potassium cocoyl glutamate. In certain embodiments, the glutamate surfactant is selected from the group consisting of sodium cocoyl glutamate and potassium cocoyl glutamate. 12 Alkyl or C 14 In certain embodiments, the glutamate surfactant is selected from those according to formula (Z): 16 Alkyl or C 18 is selected from those according to formula (Z):

[0062] In certain embodiments, the cosmetic compositions described elsewhere herein comprise from 0.01% to 30%, or from 1% to 25%, preferably from 5% to 20%, and more preferably from 12% to 18% by weight of a glutamate surfactant.

[0063] In certain embodiments, the cosmetic compositions described elsewhere herein contain a nonionic surfactant. The nonionic surfactant may be present in the range of 0 to 5% by weight. Nonionic surfactants that may be included in the compositions herein include condensation products of aliphatic primary or secondary linear or branched alcohols or phenols with alkylene oxides, usually ethylene oxide, generally having 6 to 30 ethylene oxide groups. Alkyl ethoxylates are particularly preferred. Most preferred are alkyl ethoxylates having the following formula: R-(OCH2CH2) n OH [In the formula, R is C 12 ~C 15 and n is 5 to 9.

[0064] Other suitable nonionic surfactants include mono- or dialkyl alkanolamides. Examples include coco mono- or di-ethanolamide and coco mono-isopropanolamide.

[0065] Yet another nonionic surfactant that can be included in the compositions of the present invention is an alkyl polyglycoside (APG). Typically, an APG comprises an alkyl group linked (optionally via a bridging group) to a block of one or more glycosyl groups. Preferred APGs are defined by the following formula: RO-(G)n [In the formula, n is an integer from about 1 to about 50; R is a branched or straight chain alkyl group which may be saturated or unsaturated; and G is a saccharide group. In certain embodiments, R is from about C to about C 20 It may represent an average alkyl chain length of

[0066] Preferably, R is from about C to about C 12represents the average alkyl chain length. G can be selected from C5 or C6 monosaccharide residues, preferably a glucoside. G can be selected from the group including glucose, xylose, lactose, fructose, mannose, and derivatives thereof. Preferably, G is glucose. The degree of polymerization, n, can have a value of about 1 to about 10 or more. Most preferably, the value of n is about 1.3 to about 1.5. Alkyl polyglycosides suitable for use in the present invention are commercially available and include, for example, materials identified below: Oramix NS10 from Seppic; Plantaren 1200 and Plantaren 2000 from Henkel.

[0067] In certain embodiments, the nonionic surfactant has an HLB (hydrophilic lipophilic balance) greater than 12. Optionally, the nonionic surfactant is selected from the group consisting of ethoxylated or ethoxylated / propoxylated fatty alcohols having a fatty chain containing 12 to 22 carbon atoms, ethoxylated sterols such as stearyl or lauryl alcohol (EO-7), PEG-16 soybean sterol or PEG-10 soybean sterol, polyoxyethylene polyoxypropylene block polymers (poloxamers), and mixtures thereof.

[0068] In certain embodiments, the nonionic surfactant is an ethoxylated fatty alcohol, fatty acid, fatty acid glyceride or alkylphenol, particularly a C8-C6 alkylphenol having 2 to 30 moles of ethylene oxide and / or 1 to 5 moles of propylene oxide. 22 -addition products onto fatty alcohols, C 12 -~C 22 -C of addition products onto fatty acids or onto alkylphenols having 8 to 15 carbon atoms in the alkyl group, addition products of 1 to 30 moles of ethylene oxide onto glycerol, or addition products of 5 to 60 moles of ethylene oxide onto castor oil or onto hydrogenated castor oil 12 -~C 22 -Fatty acid mono- and diesters, fatty acid sugar esters, especially sucrose and one or two C8-C22 - Esters of fatty acids, INCI: Sucrose cocoate, sucrose dilaurate, sucrose distearate, sucrose laurate, sucrose myristate, sucrose oleate, sucrose palmitate, sucrose ricinoleate, sucrose stearate, sorbitan and 1, 2 or 3 C8-C 22 - Esters of fatty acids with an ethoxylation degree of 4 to 20, in particular one, two or more C8-C 22 - Polyglyceryl fatty acid esters, C8-C, of ​​fatty acids and polyglycerols, preferably having 2 to 20 glyceryl units 22 -alkyl radicals, alkyl oligoglucosides and alkyl polyglucosides, such as decyl glucoside or lauryl glucoside, and mixtures thereof.

[0069] In certain embodiments, the nonionic surfactant is a fatty alcohol ethoxylate (alkyl polyethylene glycol), alkylphenol polyethylene glycol, alkyl mercaptan polyethylene glycol, fatty amine ethoxylate (alkylamino polyethylene glycol), fatty acid ethoxylate (acyl polyethylene glycol), polypropylene glycol ethoxylate (Pluronics (登録商標) ), fatty acid alkylolamides, (fatty acid amide polyethylene glycols), N-alkyl-, N-alkoxy polyhydroxy-fatty acid amides, sucrose esters, sorbitol esters, polyglycol ethers, and mixtures thereof.

[0070] Other sugar-derived nonionic surfactants that can be included in the compositions of the present invention include fatty (e.g., C O ... 10 -C 18 ) N-alkyl (C1-C6) polyhydroxy fatty acid amides, such as C 12 ~C 18 These include N-methylglucamides, and N-alkoxypolyhydroxyfatty acid amides.

[0071] In certain embodiments, the cosmetic compositions described elsewhere herein comprise a fatty N-methyl-N-glucamide surfactant, in certain embodiments, the fatty N-methyl-N-glucamide surfactant conforms to formula (X):

[0072] [ka] During the ceremony, R is a linear or branched alkyl or alkenyl group having 3 to 30 carbon atoms. In certain embodiments, R is an alkyl group having 3 to 30 carbon atoms. In certain embodiments, R is a saturated aliphatic hydrocarbon group which may be linear or branched and may have 3 to 20 carbon atoms in the hydrocarbon chain (preferably linear or branched). Branched means that a lower alkyl group, such as methyl, ethyl, or propyl, is present as a substituent on a linear alkyl chain. In certain embodiments, R is 1-propyl, 2-propyl, 1-butyl, 2-butyl, 2-methyl-1-propyl (isobutyl), 2-methyl-2-propyl (tert-butyl), 1-pentyl, 2-pentyl, 3-pentyl, 2-methyl-1-butyl, 3-methyl-1-butyl, 2-methyl-2-butyl, 3-methyl-2-butyl, 2,2-dimethyl-1-propyl, 1-hexyl, 2-hexyl, 3-hexyl, 2-methyl-1-pentyl, 3-methyl-1-pentyl, 4-methyl-1-pentyl, 2-methyl-2-propyl ... The fatty N-methyl-N-glucamide surfactant is selected from the group consisting of ethyl-2-pentyl, 3-methyl-2-pentyl, 4-methyl-2-pentyl, 2-methyl-3-pentyl, 3-methyl-3-pentyl, 2,2-dimethyl-1-butyl, 2,3-dimethyl-1-butyl, 3,3-dimethyl-1-butyl, 2-ethyl-1-butyl, 2,3-dimethyl-2-butyl, 3,3-dimethyl-2-butyl, 1-heptyl, 1-octyl, 1-nonyl, 1-decyl, 1-undecyl, 1-dodecyl, 1-tetradecyl, 1-hexadecyl and 1-octadecyl.Suitable fatty N-methyl-N-glucamide surfactants are described in WO2013178700A2 (Clariant) by Klug et al. and EP0550637B1 (P&G) by Connor et al., which are incorporated herein by reference. In certain embodiments, the fatty N-methyl-N-glucamide surfactant is 12 Alkyl or C 14 In a particular embodiment, the fatty N-methyl-N-glucamide surfactant is selected from those according to formula (X) where R is C 16 Alkyl or C 18 is selected from those according to formula (X):

[0073] In certain embodiments, the cosmetic compositions described elsewhere herein comprise from 1% to 20% by weight of a nonionic surfactant, more preferably from 2% to 10% by weight, and even more preferably from 3% to 7% by weight.

[0074] In certain embodiments, the cosmetic compositions described elsewhere herein comprise from 1% to 20% by weight of a fatty N-methyl-N-glucamide surfactant, more preferably from 2% to 10% by weight, and even more preferably from 3% to 7% by weight.

[0075] The amphoteric or zwitterionic surfactant(s) may be present in the composition in an amount ranging from 0.5% to about 8% by weight of the total composition, preferably from 1% to 4%.

[0076] In certain embodiments, the amphoteric surfactants are N—(C) as alkali metal salts and mono-, di-, and trialkylammonium salts. 12 -C 18 )-Alkyl-β-aminopropionates and N-(C 12 -C 18 )-Alkyl-β-iminodipropionates; N-Acylaminoalkyl-N,N-dimethylacetobetaines, preferably N-(C 18 )-Acylaminopropyl-N,N-dimethylacetobetaine, (C 12 -C 18 )-Alkyl-dimethylsulfopropyl betaine, an imidazoline-based amphoteric surfactant (trade name: Miranol (登録商標) , Steinapon (登録商標) ), preferably the sodium salt of 1-(β-carboxymethyloxyethyl)-1-(carboxymethyl)-2-laurylimidazolinium; amine oxides, such as (C 12 -C 18 )-alkyl-dimethylamine oxides, fatty acid amide alkyldimethylamine oxides, and mixtures thereof.

[0077] In certain embodiments, the cosmetic compositions described elsewhere herein comprise a betaine surfactant. Optionally, the betaine surfactant is a C8-C 18 In certain embodiments, the betaine surfactant is selected from the group consisting of cocodimethylcarboxymethyl betaine, lauryldimethylcarboxymethyl betaine, lauryldimethylalphacarboxyethyl betaine, cetyldimethylcarboxymethyl betaine, oleyldimethylgammacarboxypropyl betaine, and laurylbis(2-hydroxypropyl)alphacarboxyethyl betaine, and combinations thereof. Optionally, the betaine surfactant is selected from the group consisting of C8- to C 18 In certain embodiments, the betaine surfactant is selected from the group consisting of cocodimethylsulfopropyl betaine, stearyldimethylsulfopropyl betaine, lauryldimethylsulfoethyl betaine, laurylbis(2-hydroxyethyl)sulfopropyl betaine, and combinations thereof. Optionally, the betaine surfactant is selected from the group consisting of carboxyl derivatives of imidazole, C8- to C9-. 18 -Alkyldimethylammonium acetate, C8-~C 18 -Alkyldimethylcarbonylmethylammonium salts, and C8- to C 18 -fatty acid alkylamido betaines and mixtures thereof. Optionally, the C8- to C 18The fatty acid alkylamidobetaine is selected from coconut fatty acid amidopropyl betaine, N-cocoamidoethyl-N-[2-(carboxymethoxy)ethyl]glycerol (CTFA name: cocoamphocarboxyglycinate), and mixtures thereof. A particularly preferred amphoteric or zwitterionic surfactant is cocamidopropyl betaine. Mixtures of any of the aforementioned amphoteric or zwitterionic surfactants may also be suitable. A preferred mixture is a mixture of cocamidopropyl betaine with another amphoteric or zwitterionic surfactant, as described above. A preferred further amphoteric or zwitterionic surfactant is sodium cocoamphoacetate.

[0078] In certain embodiments, the cosmetic compositions described elsewhere herein comprise from 0.5% to 20% by weight, preferably from 1% to 10% by weight, of an amphoteric surfactant.

[0079] In certain embodiments, the cosmetic compositions described elsewhere herein contain a surfactant system. In certain embodiments, the surfactant system contains at least one surfactant selected from the group consisting of lauryl sulfate, laureth sulfate, cocoamidopropyl betaine, sodium cocoyl glutamate, lauroamphoacetate, and mixtures thereof. In certain embodiments, the surfactant system contains sodium laureth sulfate, sodium lauryl sulfate, and optionally cocamidopropyl betaine. In certain embodiments, the surfactant system contains sodium laureth sulfate, potassium cocoyl glutamate, and cocamidopropyl betaine.

[0080] auxiliary agent In certain embodiments, the cosmetic compositions described elsewhere herein comprise at least one additive common in cosmetology, pharmacy, and dermatology, hereinafter referred to as an adjuvant. In certain embodiments, the composition comprises an adjuvant. In certain embodiments, the adjuvant is cosmetically acceptable. In certain embodiments, the adjuvant is an oil, a wax, an emulsifier, a co-emulsifier, a solubilizer, a cationic polymer, a film former, a superfatting agent, a refatting agent, a foam stabilizer, a stabilizer, an active biological substance, a preservative, a preservation boosting ingredient, a surfactant ... ingredients), antifungals, antidandruff agents, dyes or pigments, particulate matter, opacifiers, abrasives, absorbents, anti-caking agents, bulking agents, pearlescent agents, direct dyes, perfumes or fragrances, carriers, solvents or diluents, propellants, functional acids, active ingredients, skin brighteners, self-tanning agents, exfoliants, enzymes, anti-acne agents, deodorants and antiperspirants, viscosity modifiers, thickening and gelling agents, pH adjusters, buffers, antioxidants, chelating agents, astringents, sunscreens, sun protection agents, UV blocking agents, skin conditioning agents, emollients, moisturizing agents, occlusive agents, pediculicides, anti-foaming agents, flavorings, electrolytes, oxidizing agents and reducing agents.

[0081] In certain embodiments, the cosmetic compositions described elsewhere herein comprise an oil or wax. In certain embodiments, the cosmetic compositions described elsewhere herein comprise an oil or wax, wherein the oil or wax is selected from the group consisting of silicone oils (volatile or non-volatile, linear, branched or cyclic, optionally organically modified); phenyl silicones; silicone resins and silicone gums; mineral oils, such as paraffin oil or petrolatum oil; oils of animal origin, such as perhydrosqualene, lanolin; oils of plant origin, such as liquid triglycerides, for example, sunflower oil, corn oil, soybean oil, rice oil, jojoba oil, babassu oil, pumpkin oil, grape seed oil, sesame oil, walnut oil, apricot oil, macadamia oil, avocado oil, almond oil, cardamom oil (lady's-smock oil). oil), castor oil, caprylic / capric triglyceride, olive oil, peanut oil, rapeseed oil, argan oil, Abyssinian oil and coconut oil; synthetic oils, such as purcellin oil, isoparaffins, linear and / or branched fatty alcohols and fatty acid esters, preferably Guerbet alcohols having 6 to 18, preferably 8 to 10, carbon atoms; linear (C6-C 13 ) fatty acids and linear (C6-C 20 ) Esters with fatty alcohols; branched (C6-C 13 ) carboxylic acids and linear (C6-C 20 ) Esters with fatty alcohols, linear (C6-C 18 ) Esters of fatty acids with branched alcohols, in particular 2-ethylhexanol; esters of linear and / or branched fatty acids with polyhydric alcohols (e.g., dimerdiol, trimerdiol, etc.) and / or Guerbet alcohols; (C6-C 10) fatty acid-based triglycerides; esters such as dioctyl adipate, diisopropyl dimer dilinoleate; propylene glycol / dicaprylate or waxes such as beeswax, paraffin wax or microcrystalline wax (alone or in combination with hydrophilic waxes such as cetylstearyl alcohol); fluorinated and perfluorinated oils; fluorinated silicone oils; mixtures of the aforementioned compounds.

[0082] In certain embodiments, the cosmetic composition as described elsewhere herein comprises an oily substance, which is any fatty substance that is liquid at room temperature (25° C.). In preferred embodiments, the oily substance is selected from the group consisting of sweet almond oil, caprylic / capric triglyceride, dimethicone, mineral oil, squalane, castor oil, isopropyl isostearate, jojoba oil, dicaprylyl carbonate, isohexadecane, C 12 ~C 15 In certain embodiments, the cosmetic compositions described elsewhere herein comprise from 0.001% to 60% by weight, preferably from 0.05% to 50% by weight, and even more preferably from 0.1% to 40% by weight of at least one oily material.

[0083] In preferred embodiments, the wax is selected from the group consisting of carnauba wax, beeswax, candelilla wax, synthetic wax, polyethylene, paraffin wax, microcrystalline wax, hydrogenated vegetable oil, hydrogenated castor oil, rice bran wax, cetyl dimethicone, bis-PEG-18 methyl ether dimethyl silane, and combinations thereof. In certain embodiments, the cosmetic compositions described elsewhere herein comprise 0.001% to 30% by weight, preferably 0.05% to 20% by weight, and even more preferably 0.1% to 10% by weight, of at least one wax.

[0084] In certain embodiments, the cosmetic compositions described elsewhere herein include an emulsifier, coemulsifier, or solubilizer. Nonionic, anionic, cationic, or amphoteric surface-active compounds can be used as emulsifiers, coemulsifiers, and solubilizers.

[0085] As nonionogenic surface-active compounds, the following may preferably be considered: addition products of 0 to 30 moles of ethylene oxide and / or 0 to 5 moles of propylene oxide onto linear fatty alcohols having 8 to 22 carbon atoms, onto fatty acids having 12 to 22 carbon atoms, onto alkylphenols having 8 to 15 carbon atoms in the alkyl group, and onto sorbitan or sorbitol esters; addition products of 0 to 30 moles of ethylene oxide onto glycerol (C 12 -C 18 )-fatty acid mono- and diesters; glycerol mono- and diesters and sorbitan mono- and diesters of saturated and unsaturated fatty acids having 6 to 22 carbon atoms, and optionally their ethylene oxide addition products; addition products of 15 to 60 moles of ethylene oxide onto castor oil and / or hydrogenated castor oil; polyols and, in particular, polyglycerol esters, such as polyglycerol polyricinoleate and polyglycerol poly-12-hydroxystearate. Ethoxylated fatty amines, fatty acid amides, fatty acid alkanolamides, and mixtures of compounds from several of these classes of substances are also suitable. Polymeric ethers formed by block polymerization of ethylene or propylene oxide, known as poloxamers, are also suitable.

[0086] Suitable ionogenic co-emulsifiers are, for example, anionic emulsifiers, such as mono-, di- or triphosphate esters, soaps (e.g., sodium stearate), fatty alcohol sulfates, and cationic emulsifiers, such as mono-, di- and tri-alkyl quats and their polymeric derivatives.

[0087] Usable amphoteric emulsifiers are preferably alkylaminoalkylcarboxylic acids, betaines, sulfobetaines and imidazoline derivatives.

[0088] Fatty alcohol ethoxylates are particularly preferably used, such as ethoxylated stearyl alcohol, isostearyl alcohol, cetyl alcohol, isocetyl alcohol, oleyl alcohol, lauryl alcohol, isolauryl alcohol and cetylstearyl alcohol, in particular polyethylene glycol (13) stearyl ether, polyethylene glycol (14) stearyl ether, polyethylene glycol (15) stearyl ether, polyethylene glycol (16) stearyl ether, polyethylene glycol (17) stearyl ether, polyethylene glycol (18) stearyl ether, polyethylene glycol (19) stearyl ether, polyethylene glycol (20) stearyl ether, polyethylene glycol (12) isostearyl ether, polyethylene glycol (13) isostearyl ether, polyethylene glycol (14) isostearyl ether, polyethylene glycol (15) isostearyl ether, polyethylene glycol (16) isostearyl ether, polyethylene glycol (17) iso ... 18) Isostearyl ether, polyethylene glycol (19) Isostearyl ether, polyethylene glycol (20) Isostearyl ether, polyethylene glycol (13) Cetyl ether, polyethylene glycol (14) Cetyl ether, polyethylene glycol (15) Cetyl ether, polyethylene glycol (16) Cetyl ether, polyethylene glycol (17) Cetyl ether, polyethylene glycol (18) Cetyl ether, polyethylene glycol (19) Cetyl ether, polyethylene glycol (20) Cetyl ether, polyethylene glycol (13) Isocetyl ether, polyethylene glycol (14) Isocetyl ether, polyethylene glycol (15) Isocetyl ether, polyethylene glycol (16) Isocetyl ether, polyethylene glycol (17) Isocetyl ether, polyethylene glycol (18) Isocetyl ether, polyethylene glycol (19) Isocetyl ether, polyethylene glycol (20) Isocetyl ether, polyethylene glycol (12) Oleyl ether, polyethylene glycol (13) Oleyl ether,The hydroxybenzoates may be selected from the group consisting of polyethylene glycol (14) oleyl ether, polyethylene glycol (15) oleyl ether, polyethylene glycol (12) lauryl ether, polyethylene glycol (12) isolauryl ether, polyethylene glycol (13) cetylstearyl ether, polyethylene glycol (14) cetylstearyl ether, polyethylene glycol (15) cetylstearyl ether, polyethylene glycol (16) cetylstearyl ether, polyethylene glycol (17) cetylstearyl ether, polyethylene glycol (18) cetylstearyl ether, and polyethylene glycol (19) cetylstearyl ether.

[0089] Fatty acid ethoxylates are also preferred, including ethoxylated stearates, isostearate and oleates, in particular polyethylene glycol (20) stearate, polyethylene glycol (21) stearate, polyethylene glycol (22) stearate, polyethylene glycol (23) stearate, polyethylene glycol (24) stearate, polyethylene glycol (25) stearate, polyethylene glycol (12) isostearate, polyethylene glycol (13) isostearate, polyethylene glycol (14) isostearate, polyethylene glycol (15) isostearate, polyethylene glycol (16) isostearate, polyethylene glycol (17) isostearate, polyethylene glycol (18) isostearate, polyethylene glycol (19) isostearate, polyethylene glycol (20) isostearate, polyethylene glycol (21) isostearate, polyethylene glycol (22) isostearate, polyethylene glycol (23) isostearate, polyethylene glycol (24) stearate, polyethylene glycol (25) stearate, polyethylene glycol (12) isostearate, polyethylene glycol (13) isostearate, polyethylene glycol (14) isostearate, polyethylene glycol (15) isostearate, polyethylene glycol (16) isostearate, polyethylene glycol (17) isostearate, polyethylene glycol (18) isostearate, polyethylene glycol (19) isostearate, polyethylene glycol (21) isostearate, polyethylene glycol (22) isostearate, polyethylene glycol (23) isostearate, polyethylene glycol (24) isostearate, polyethylene glycol (25) isostearate, polyethylene glycol (12) isostearate, polyethylene glycol (13) isostearate, polyethylene glycol (14) isostearate, polyethylene glycol (15) isostearate, polyethylene glycol (16) isostearate, polyethylene glycol (17) isostearate, polyethylene glycol (18) isostearate, polyethylene glycol (19) isostearate, polyethylene glycol (19) isostearate, polyethylene glycol (19) isostearate, polyethylene glycol (19 The oleic acid may be selected from the group consisting of polyethylene glycol (19) isostearate, polyethylene glycol (20) isostearate, polyethylene glycol (21) isostearate, polyethylene glycol (22) isostearate, polyethylene glycol (23) isostearate, polyethylene glycol (24) isostearate, polyethylene glycol (25) isostearate, polyethylene glycol (12) oleate, polyethylene glycol (13) oleate, polyethylene glycol (14) oleate, polyethylene glycol (15) oleate, polyethylene glycol (16) oleate, polyethylene glycol (17) oleate, polyethylene glycol (18) oleate, polyethylene glycol (19) oleate, and polyethylene glycol (20) oleate.

[0090] Sodium laureth-11-carboxylate can be advantageously used as the ethoxylated alkyl ether carboxylic acid or salt thereof.

[0091] Polyethylene glycol (60) evening primrose glyceride can be advantageously used as the ethoxylated triglyceride.

[0092] Furthermore, it is advantageous to select the polyethylene glycol glycerol fatty acid esters from the group polyethylene glycol (20) glyceryl laurate, polyethylene glycol (6) glyceryl caprate / caprinate, polyethylene glycol (20) glyceryl oleate, polyethylene glycol (20) glyceryl isostearate and polyethylene glycol (18) glyceryl oleate / cocoate.

[0093] Among the sorbitan esters, the following are particularly preferred: polyethylene glycol (20) sorbitan monolaurate, polyethylene glycol (20) sorbitan monostearate, polyethylene glycol (20) sorbitan monoisostearate, polyethylene glycol (20) sorbitan monopalmitate, polyethylene glycol (20) sorbitan monooleate.

[0094] Particularly advantageous co-emulsifiers are glyceryl monostearate, glyceryl monooleate, diglyceryl monostearate, glyceryl isostearate, polyglyceryl-3-oleate, polyglyceryl-3-diisostearate, polyglyceryl-4-isostearate, polyglyceryl-2-dipolyhydroxystearate, polyglyceryl-4-dipolyhydroxystearate, PEG-30-dipolyhydroxystearate, diisostearoylpolyglyceryl-3-diisostearate, glycol distearate, and polyglyceryl-3-dipolyhydroxystearate, sorbitan monoisostearate, sorbitan stearate, sorbitan oleate, sucrose distearate, lecithin, PEG-7 hydrogenated castor oil, cetyl alcohol, stearyl alcohol, behenyl alcohol, isobehenyl alcohol and polyethylene glycol (2) stearyl ether (steareth-2), alkyl methicone copolyols and alkyl dimethicone copolyols, especially cetyl dimethicone copolyol (ABIL (登録商標) EM 90) or lauryl methicone copolyol.

[0095] In preferred embodiments, the emulsifier, co-emulsifier or solubilizer is selected from the group consisting of glyceryl stearate, cetearyl alcohol, polysorbate 20, stearic acid, cetearyl glucoside, PEG-40 hydrogenated castor oil, cetyl phosphate, steareth-2, ceteth-10 phosphate, trilaureth-4 phosphate, polyglyceryl-2 sesquiisostearate, cetyl PEG / PPG-10 / 1 dimethicone, cetrimonium chloride, and combinations thereof.

[0096] In certain embodiments, the cosmetic compositions described elsewhere herein comprise from 0.1% to 20% by weight, preferably from 0.5% to 10% by weight, and even more preferably from 1.0% to 5.0% by weight of at least one emulsifier, co-emulsifier, and / or solubilizer.

[0097] In certain embodiments, the cosmetic composition described elsewhere herein comprises a cationic polymer.Suitable cationic polymers include those known by the INCI name "Polyquaternium", in particular Polyquaternium-31, Polyquaternium-16, Polyquaternium-24, Polyquaternium-7, Polyquaternium-22, Polyquaternium-39, Polyquaternium-28, Polyquaternium-2, Polyquaternium-10, Polyquaternium-11, and Polyquaternium-37 & mineral oil & PPG trideceth (Salcare SC95), PVP-dimethylaminoethyl methacrylate copolymer, guar-hydroxypropyltriammonium chloride, and also calcium alginate and ammonium alginate. Furthermore, it is possible to use cationic cellulose derivatives; cationic starch; copolymers of diallylammonium salts and acrylamide; quaternized vinylpyrrolidone / vinylimidazole polymers; condensation products of polyglycols with amines; quaternized collagen polypeptides; quaternized wheat polypeptides; polyethyleneimine; cationic silicone polymers such as, for example, amidomethicone; copolymers of adipic acid and dimethylaminohydroxypropyldiethylenetriamine; polyaminopolyamides and cationic chitin derivatives (such as, for example, chitosan).

[0098] In a preferred embodiment, the cationic polymer is selected from the group consisting of polyquaternium-10, guar hydroxypropyltrimonium chloride, polyquaternium-7, polyquaternium-6, and combinations thereof.

[0099] In certain embodiments, the cosmetic compositions described elsewhere herein comprise from 0.1% to 10% by weight, preferably from 0.5% to 7.5% by weight, and even more preferably from 1.0% to 5.0% by weight of at least one cationic polymer.

[0100] In certain embodiments, the cosmetic compositions described elsewhere herein include a film-forming agent. Film-forming agents are materials, such as synthetic or natural polymers and their derivatives, that produce a continuous film on the skin, hair, or nails. Depending on the intended use, the composition according to the present invention may comprise a film-forming agent selected from salts of phenylbenzimidazole sulfonic acid, water-soluble polyurethanes such as C10-polycarbamyl polyglyceryl esters, polyvinyl alcohol, polyvinylpyrrolidone (PVP) copolymers, vinylpyrrolidone / vinyl acetate copolymers or PVP / eicosene copolymers, vinylpyrrolidone / alkene copolymers such as VP / eicosene copolymers or VP / hexadecene copolymers, PVM / MA copolymers or esters thereof, maleated polypropylene polymers, water-soluble acrylic acid polymers / copolymers or esters or salts thereof, such as partial ester copolymers of acrylic acid / methacrylic acid, polyalkylsilsesquioxanes, polyacrylamides, water-soluble celluloses such as hydroxymethylcellulose, hydroxyethylcellulose, hydroxypropylcellulose, water-soluble quaterniums, polyquaterniums, carboxyvinyl polymers such as carbomers and salts thereof, polysaccharides such as polydextrose and glucans, and vinyl acetate / crotonate.

[0101] In a preferred embodiment, the film-forming agent is selected from the group consisting of VP / eicosene copolymer, PVP, VP / VA copolymer, styrene / acrylate copolymer, acrylate copolymer, butyl ester of PVM / MA copolymer, hydroxyethyl cellulose, polyquaternium-10, polypropylsilsesquioxane, polyurethane-64, and combinations thereof.

[0102] In certain embodiments, the cosmetic compositions described elsewhere herein comprise from 0.1% to 10% by weight, preferably from 0.5% to 7.5% by weight, and even more preferably from 1.0% to 5.0% by weight of at least one film-forming agent.

[0103] In certain embodiments, the cosmetic compositions described elsewhere herein contain a superfatting agent and / or a refatting agent. Examples of the superfatting agent include lanolin, polyethoxylated lanolin derivatives, lecithin, lecithin derivatives, non-ethoxylated and polyethoxylated or acylated lanolin and lecithin derivatives, and polyol fatty acid esters, such as glyceryl oleate, mono-, di-, and triglycerides, and / or fatty acid alkanolamides. These compounds can also function as foam stabilizers. In a preferred embodiment, the superfatting agent and / or a refatting agent is selected from the group consisting of lanolin, glyceryl ricinoleate, PEG-8 glyceryl laurate, glyceryl oleate, cocamide MEA, PEG-75 lanolin, and combinations thereof. In certain embodiments, the cosmetic compositions described elsewhere herein comprise from 0.01% to 10% by weight, preferably from 0.1% to 5.0% by weight, and even more preferably from 0.5% to 3.0% by weight of at least one superfatting and / or refatting agent.

[0104] In certain embodiments, the cosmetic compositions described elsewhere herein contain a stabilizer. Metal salts of fatty acids, such as magnesium stearate, aluminum, and / or zinc, can be used as the stabilizer. In a preferred embodiment, the stabilizer is selected from the group consisting of aluminum stearate, aluminum isostearate / myristate, magnesium stearate, magnesium cocoate, zinc palmitate, zinc stearate, and combinations thereof. In certain embodiments, the cosmetic compositions described elsewhere herein contain 0.01% to 10% by weight, preferably 0.5% to 8.0% by weight, and even more preferably 1.0% to 5.0% by weight of at least one stabilizer.

[0105] In certain embodiments, the cosmetic compositions described elsewhere herein comprise a biologically-sourced substance. In certain embodiments, the cosmetic compositions described elsewhere herein comprise a biologically-sourced substance, wherein such substance is selected from the group consisting of plant extracts (e.g., leaf, root, seed, flower, and / or stem extracts from aloe vera, chamomile, green tea, witch hazel, or licorice), local anesthetics, antibiotics, anti-inflammatory agents, anti-allergic agents, hormones, beta-glucans, cholesterol, amino acids, ceramides, corticosteroids, sebostatics, bisabololol, and the like. (登録商標) , Allantoin, Phytantriol (登録商標) Vitamins selected from protein, niacin, biotin, vitamin B2, vitamin B3, vitamin B6, vitamin B5, vitamin B3 derivatives (salts, acids, esters, amides, alcohols), vitamin C and vitamin C derivatives (salts, acids, esters, amides, alcohols), preferably as the sodium salt of the monophosphate ester of ascorbic acid or as the magnesium salt of the phosphate ester of ascorbic acid, tocopherol and tocopherol acetate, vitamin E and / or its derivatives, protein derivatives such as gelatin, collagen hydrolysate, polypeptides, egg yolk, lecithin, hydrolyzed silk, hydrolyzed keratin, milk protein, cerebrosides, or phospholipids. In a preferred embodiment, the biogenic active substance is selected from the group consisting of aloe vera extract, collagen hydrolysate, bisabolol, vitamin C, vitamin E, allantoin, vitamin B5, tocopherol acetate, retinyl palmitate, and combinations thereof. In certain embodiments, the cosmetic compositions described elsewhere herein comprise from 0.001% to 5.0% by weight, preferably from 0.01% to 3.0% by weight, and even more preferably from 0.1% to 2.0% by weight of at least one biogenic active material.

[0106] In certain embodiments, the cosmetic compositions described elsewhere herein contain a preservative, a preservative-boosting component, an antifungal agent, and / or an antidandruff agent. In certain embodiments, the preservative is selected from the group consisting of benzyl alcohol, piroctone olamine, phenoxyethanol, parabens, pentanediol, benzoic acid / sodium benzoate, sorbic acid / potassium sorbate, and combinations thereof. Other organic acids may also be used to provide antimicrobial protection. In certain embodiments, the preservative-boosting component is selected from the group consisting of anisic acid, lactic acid, sorbitan caprylate, ethylhexylglycerin, caprylyl glycol, octanediol, and mixtures thereof. Suitable preservative-boosting components are also disclosed in International Patent Application WO2018002100A1 (PCT / EP2017 / 065927) by Clariant International Ltd. (see, in particular, Claim 1 therein), which is incorporated herein by reference. In certain embodiments, the cosmetic compositions described elsewhere herein contain 0.01 to 5.0 wt. %, and particularly preferably 0.05 to 1.0 wt. %, of at least one preservative. Suitable preservatives include those listed under the function "preservatives" in the International Cosmetic Ingredients Dictionary & Handbook, 9th Edition. In certain embodiments, the preservative is selected from the group consisting of phenoxyethanol, benzylparaben, butylparaben, ethylparaben, isobutylparaben, isopropylparaben, methylparaben, propylparaben, iodopropynyl butylcarbamate, methyldibromoglutaronitrile, DMDM ​​hydantoin, and combinations thereof. In certain embodiments, the cosmetic compositions described elsewhere herein may comprise any of cetyltrimethylammonium chloride, cetylpyridinium chloride, benzethonium chloride, diisobutylethoxyethyldimethylbenzylammonium chloride, sodium N-lauryl sarcosinate, sodium N-palmethyl sarcosinate, lauroyl sarcosine, N-myristoyl glycine, potassium N-lauryl sarcosinate, trimethylammonium chloride, sodium aluminum chlorohydroxylactate, triethyl citrate, tricetylmethylammonium chloride, 2,4,4'-Trichloro-2'-hydroxydiphenyl ether (Triclosan), phenoxyethanol, 1,5-pentanediol, 1,6-hexanediol, 3,4,4'-trichlorocarbanilide (Triclocarban), diaminoalkylamides, L-lysine hexadecylamide, heavy metal citrates, salicylates, piroctose, zinc salts, pyrithione and its heavy metal salts, zinc pyrithione, zinc phenol sulfate, farnesol, ketoconazole, oxiconazole, bifonazole, butoconazole, Roconazole, clotrimazole, econazole, enilconazole, fenticonazole, isoconazole, miconazole, sulconazole, tioconazole, fluconazole, itraconazole, terconazole, naftifine, terbinafine, selenium disulfide, methylchloroisothiazolinone, methylisothiazolinone, methyldibromoglutaronitrile, silver chloride (AgCl), diazolidinyl urea, imidazolidinyl urea, dehydroacetic acid, undecylenic acid, chlorphenesin, propionic acid acid), salicylic acid, chloroxylenol, sodium salt of diethylhexyl sulfosuccinate, sodium benzoate, phenoxyethanol, (RS)-1-(4-chlorophenoxy)-1-imidazol-1-yl-3,3-dimethylbutan-2-one (climbazole), benzyl alcohol, phenoxyisopropanol, parabens such as butyl-, ethyl-, methyl- and propylparaben and their salts, 2-bromo-2-nitropropane-1,3-diol, polyaminopropyl biguanide, phenoxyisopropanol, iodopropynyl butylcarbamate, benzalkonium chloride, benzethonium chloride, pentanediol, 1,The composition contains a preservative selected from the group consisting of 2-octanediol, ethylhexylglycerin, sorbic acid, benzoic acid, lactic acid, imidazolidinyl urea, diazolidinyl urea, dimethyloldimethylhydantoin (DMDMH), chlorhexidine, sodium hydroxymethylglycinate, hydroxyethylglycine of sorbic acid, and combinations thereof. In certain embodiments, the preservative is selected from the group consisting of phenoxyethanol, benzylparaben, butylparaben, ethylparaben, isobutylparaben, isopropylparaben, methylparaben, propylparaben, iodopropynyl butylcarbamate, methyldibromoglutaronitrile, DMDM ​​hydantoin, and combinations thereof. In certain embodiments, the composition is substantially free of parabens.

[0107] In certain embodiments, the cosmetic compositions described elsewhere herein comprise 0.1% to 5.0% by weight of an antimicrobial agent. In certain embodiments, the antimicrobial combination composition is chlorhexidine.

[0108] In certain embodiments, the cosmetic compositions described elsewhere herein include an antifungal substance. In certain embodiments, the antifungal substance is selected from the group consisting of ketoconazole, oxconazole, bifonazole, butoconazole, cloconazole, clotrimazole, econazole, enilconazole, fenticonazole, isoconazole, miconazole, sulconazole, tioconazole, fluconazole, itraconazole, terconazole, naftifine, terbinafine, zinc pyrithione, piroctone olamine (Octopirox), and the like. (登録商標)), (RS)-1-(4-chlorophenoxy)-1-imidazol-1-yl-3,3-dimethylbutan-2-one (climbazole), and mixtures thereof. In certain embodiments, the cosmetic compositions described elsewhere herein comprise a total amount of antifungal material of 0.1% to 1.0% by weight in the composition. In certain embodiments, the cosmetic compositions described elsewhere herein comprise pyridinethione anti-dandruff microparticles, for example, 1-hydroxy-2-pyridinethione salts are highly preferred particulate anti-dandruff agents. The concentration of pyridinethione anti-dandruff microparticles may range from 0.1% to 4.0% of the formulation, preferably from 0.1% to 3.0%, and more preferably from 0.3% to 2.0%. Preferred pyridinethione salts include those formed from heavy metals such as zinc, tin, cadmium, magnesium, aluminum, and zirconium, preferably zinc, more preferably the zinc salt of 1-hydroxy-2-pyridinethione (known as "zinc pyridinethione" or "ZPT"), more preferably the 1-hydroxy-2-pyridinethione salt in platelet particle form.Salts formed from other cations, such as sodium, may also be suitable.Pyridinethione antidandruff agents are described in, for example, U.S. Patents US2809971; US3236733; US3761418; US4345080; US4323683; US4379753 and US4470982.When ZPT is used as an antidandruff agent microparticle in the composition herein, it is expected that hair growth or regrowth can be stimulated or regulated (or both), or hair loss can be reduced or inhibited, or hair can appear thicker or more abundant.

[0109] In certain embodiments, the cosmetic compositions described elsewhere herein comprise a preservative system comprising a plurality of different compounds selected from the group consisting of preservatives, preservative boosting ingredients, antifungal agents, and antidandruff agents.

[0110] In certain embodiments, the cosmetic compositions described elsewhere herein comprise a dye or pigment. In certain embodiments, the cosmetic compositions described elsewhere herein comprise at least one dye or pigment. Suitable dyes and pigments are disclosed in the tables on pages 36 to 43 of WO2013017262A1. These may be color pigments that impart a color effect to the product or to hair or skin, or they may be gloss effect pigments that impart a gloss effect to the product or to hair or skin. The color or gloss effect on hair or skin is preferably temporary, i.e., it lasts until the next hair or skin wash and can be removed again by washing the hair or skin with a conventional shampoo, body or face cleanser, body wash, etc., or by using makeup remover, micellar water, or cleansing wipes. In certain embodiments, the cosmetic compositions described elsewhere herein contain a total amount of at least one pigment of 0.01% to 25% by weight, preferably 0.1% to 15% by weight, and even more preferably 0.5% to 10% by weight. In certain embodiments, the particle size of the pigment is 1 micron to 200 microns, preferably 3 microns to 150 microns, and more preferably 10 microns to 100 microns. The pigment is a colorant that is substantially insoluble in the application medium and may be inorganic or organic. Inorganic-organic mixed pigments are also possible. Inorganic pigments are preferred. The advantage of inorganic pigments is their excellent resistance to light, weather, and temperature. The inorganic pigment may be of natural origin. In certain embodiments, the inorganic pigment is selected from the group consisting of chalk, ochre, umber, green earth, burnt sienna, graphite, and combinations thereof. The pigments may be, for example, white pigments such as titanium dioxide or zinc oxide, black pigments such as black iron oxide, colored pigments such as ultramarine or red iron oxide, luster pigments, metallic effect pigments, pearlescent pigments, and fluorescent or phosphorescent pigments, preferably at least one pigment is a colored non-white pigment.In certain embodiments, the pigment is selected from the group consisting of metal oxides, hydroxides and oxide hydrates, mixed-phase pigments, sulfur-containing silicates, metal sulfides, complex metal cyanides, metal sulfates, chromates and molybdates, and metals themselves (bronze, silver, gold pigments), and combinations thereof. In certain embodiments, the pigment is selected from the group consisting of titanium dioxide (CI 77891), black iron oxide (CI 77499), yellow iron oxide (CI 77492), red and brown iron oxide (CI 77491), manganese violet (CI 77742), ultramarine (sodium aluminum sulfosilicate, CI 77007, Pigment Blue 29), chromium oxide hydrate (CI 77289), Prussian blue (iron ferrocyanide, CI 77510), carmine (cochineal), and combinations thereof. In certain embodiments, pigment is selected from the group consisting of pearlescent and color pigments, which are made of single crystals such as mica, silica, bismuth oxychloride, boron nitride or titanium dioxide, or have a layer substrate structure based on mica, aluminum, aluminum oxide, titanium dioxide, silicon dioxide, silicate (for example, calcium aluminum borosilicate, sodium calcium borosilicate, magnesium aluminum silicate or sodium magnesium fluorosilicate), which are coated with metal oxide (for example, iron oxide, chromium oxide, tin oxide) or metal oxychloride, for example, titanium dioxide or bismuth oxychloride, or metal hydroxide, for example, aluminum hydroxide, and optionally with other color-imparting substances, for example, Prussian blue, ultramarine, carmine or other organic dyes, and color can be determined by changing the layer thickness.Such pigment is, for example, by Merck under the trade name RonaFlair. (登録商標) , Colorona (登録商標) , Xirona (登録商標) and Timiron (登録商標) or by BASF (Germany) under the trade name Flamenco (登録商標) , Timica (登録商標) and Cloisonne (登録商標)The pearlescent effect can be controlled by both the particle size and the particle size distribution of the pigment population. Suitable particle size distributions include, for example, 2-50 μm, 5-25 μm, 5-40 μm, 5-60 μm, 5-95 μm, 5-100 μm, 10-60 μm, 10-100 μm, 10-125 μm, 20-100 μm, 20-150 μm, and less than 15 μm. A wider particle size distribution, such as 20-150 μm, produces a shimmering effect, while a narrower particle size distribution of <15 μm provides a uniform, silky appearance. In a preferred embodiment, the pigment is selected from the group consisting of titanium dioxide (CI 77891), black iron oxide (CI 77499), yellow iron oxide (CI 77492), red and brown iron oxide (CI 77491), mica, silica, bismuth oxychloride, and combinations thereof. In certain embodiments, the pigment is selected from the group consisting of organic pigments, such as sepia, gamboge, bone charcoal, Cassel brown, indigo, chlorophyll, and other plant pigments. In certain embodiments, the pigment is selected from the group consisting of synthetic organic pigments, such as azo pigments, anthraquinoids, indigoids, dioxazines, quinacridones, phthalocyanines, isoindolinones, perylenes and perinones, metal complexes, alkali blues, and diketopyrrolopyrrole pigments.

[0111] In certain embodiments, the cosmetic composition described elsewhere herein comprises a particulate material. In certain embodiments, the composition comprises at least one particulate material. Suitable materials are, for example, materials that are solid at room temperature (25°C) and in particulate form. Suitable materials are, for example, materials that function as opacifiers, abrasives, absorbents, anti-caking agents, extenders, or performance fillers. In certain embodiments, the particulate material is selected from the group consisting of silica, silicates (e.g., sepiolite, montmorillonite, bentonite, kaolin, hectorite), aluminates, clay earths, mica, talc, starch, perlite, charcoal, pulp powder, seed powder, insoluble salts, particularly insoluble inorganic metal salts, metal oxides (e.g., titanium dioxide), minerals, and insoluble polymer particles, such as polyamide derivatives (e.g., nylon-12, nylon-6, polyamide-5), silicones (e.g., polymethylsilsesquioxane), polyesters (e.g., polyester-12), polyethylene, and polymethylmethacrylate. The particles are present in the composition in an undissolved, preferably stably dispersed form, and can be deposited on a keratin substrate in solid form following application to the substrate and evaporation of the solvent. A stable dispersion can be achieved by providing the composition with a yield point large enough to prevent the solid particles from settling. A suitable yield point can be achieved by using a suitable amount of suitable gel-forming agent.In certain embodiments, the particulate material is selected from the group consisting of silica (silica gel, silicon dioxide) and metal salts, particularly inorganic metal salts, with silica being particularly preferred.The metal salts are, for example, alkali metal or alkaline earth metal halides, such as sodium chloride or potassium chloride; alkali metal or alkaline earth metal sulfates, sodium sulfate or magnesium sulfate.In a preferred embodiment, the particulate material is selected from the group consisting of silica, mica, bentonite, kaolin, talc, polymethylsilsesquioxane, polyethylene, clay, and combinations thereof.In certain embodiments, the composition comprises from 0.01% to 20% by weight, preferably from 0.05% to 15% by weight, and even more preferably from 0.5% to 10% by weight of at least one particulate material.

[0112] In certain embodiments, the cosmetic compositions described elsewhere herein contain a pearlescent agent. In certain embodiments, the cosmetic compositions described elsewhere herein contain at least one pearlescent agent. In certain embodiments, the particulate material is selected from the group consisting of fatty acid monoalkanolamides, fatty acid dialkanolamides, monoesters or diesters of alkylene glycols, particularly ethylene glycol and / or propylene glycol or their oligomers, with higher fatty acids such as palmitic acid, stearic acid, and behenic acid, monoesters or polyesters of glycerol and carboxylic acids, fatty acids and their metal salts, ketosulfones, or mixtures of the foregoing compounds. In a preferred embodiment, the pearlescent agent is selected from the group consisting of ethylene glycol distearate and / or polyethylene glycol distearate having an average of 3 glycol units, and combinations thereof. In certain embodiments, the cosmetic compositions described elsewhere herein contain 0.1% to 15% by weight, preferably 0.5% to 10% by weight, and even more preferably 1.0% to 5.0% by weight of at least one pearlescent agent.

[0113] In certain embodiments, the cosmetic compositions described elsewhere herein comprise a direct dye. In certain embodiments, the cosmetic compositions described elsewhere herein comprise at least one direct dye. Among the direct dyes, the following compounds are preferred (alone or in combination with one another): hydroxyethyl-2-nitro-p-toluidine, 2-hydroxyethylpicramic acid, 4-nitrophenylaminourea, tri(4-amino-3-methylphenyl)carbenium chloride (Basic Violet 2), 1,4-diamino-9,10-anthracenedione (Disperse Violet 1), 1-(2-hydroxyethyl)amino-2-nitro-4-[di(2-hydroxyethyl)amino]benzene (HC Blue No. 2), 4-[ethyl-(2-hydroxyethyl)amino]-1-[(2-hydroxyethyl)amino]-2-nitrobenzene hydrochloride (HC Blue No. 12), 1-amino-4-[di(2-hydroxyethyl)amino]-2-nitrobenzene hydrochloride (HC Red No. 13), 4-amino-1-[(2-hydroxyethyl)amino]-2-nitrobenzene (HC Red No. 3), 4-amino-3-nitrophenol, 4-[(2-hydroxyethyl)amino]-3-nitrophenol, 1-amino-5-chloro-4-[(2,3-dihydroxypropyl)amino]-2-nitrobenzene (HC Red No. 10), 5-chloro-1,4-[di(2,3-dihydroxypropyl)amino]-2-nitrobenzene (HC Red No. 11), 2-chloro-6-ethylamino-4-nitrophenol, 2-amino-6-chloro-4-nitrophenol, 4-[(2-hydroxyethyl)amino]-3-nitro-1-trifluoromethylbenzene (HC Yellow No. 13), 8-amino-2-bromo-5-hydroxy-4-imino-6-{[3-(trimethylammonio)-phenyl]amino}-1(4H)-naphthalenone chloride (CI 56059; Basic Blue No. 99), 1-[(4-aminophenyl)azo]-7-(trimethylammonio)-2-naphthol chloride (CI 12250; Basic Brown No.16), 1-[(4-amino-2-nitrophenyl)azo]-7-(trimethylammonio)-2-naphthol chloride (Basic Brown No. 17), 2-hydroxy-1-[(2-methoxyphenyl)azo]-7-(trimethylammonio)naphthalene chloride (CI 12245; Basic Red No. 76), 3-methyl-1-phenyl-4-{[3-(trimethylammonio)phenyl]azo}pyrazol-5-one chloride (CI 12719; Basic Yellow No. 57), and 2,6-diamino-3-[(pyridin-3-yl)azo]pyridine and their salts. Among the above direct dyes, the following compounds are particularly preferred (alone or in combination with one another): hydroxyethyl-2-nitro-p-toluidine, 2-hydroxyethylpicramic acid, 4-nitrophenylaminourea, tri(4-amino-3-methylphenyl)carbenium chloride (Basic Violet 2), 1,4-diamino-9,10-anthracenedione (Disperse Violet 1), 1-(2-hydroxyethyl)amino-2-nitro-4-[di(2-hydroxyethyl)amino]benzene (HC Blue No. 2), 4-[ethyl-(2-hydroxyethyl)amino]-1-[(2-hydroxyethyl)amino]-2-nitrobenzene hydrochloride (HC Blue No. 12), 1-amino-4-[di(2-hydroxyethyl)amino]-2-nitrobenzene hydrochloride (HC Red No. 13), 4-amino-1-[(2-hydroxyethyl)amino]-2-nitrobenzene (HC Red No. 3), 4-amino-3-nitrophenol, 4-[(2-hydroxyethyl)amino]-3-nitrophenol, 1-amino-5-chloro-4-[(2,3-dihydroxypropyl)amino]-2-nitrobenzene (HC Red No. 10), 5-chloro-1,4-[di(2,3-dihydroxypropyl)amino]-2-nitrobenzene (HC Red No. 11), 2-chloro-6-ethylamino-4-nitrophenol, 2-amino-6-chloro-4-nitrophenol, 4-[(2-hydroxyethyl)amino]-3-nitro-1-trifluoromethylbenzene (HC Yellow No.13), 8-amino-2-bromo-5-hydroxy-4-imino-6-{[3-(trimethylammonio)-phenyl]amino}-1(4H)-naphthalenone chloride (CI 56059; Basic Blue No. 99), 1-[(4-aminophenyl)azo]-7-(trimethylammonio)-2-naphthol chloride (CI 12250; Basic Brown No. 16), 1-[(4-amino-2-nitrophenyl)azo]-7-(trimethylammonio)-2-naphthol chloride (Basic Brown No. 17), 2-hydroxy-1-[(2-methoxyphenyl)azo]-7-(trimethylammonio)naphthalene chloride (CI 12245; Basic Red No. 76), 3-methyl-1-phenyl-4-{[3-(trimethylammonio)phenyl]azo}pyrazol-5-one chloride (CI 12719; Basic Yellow No. 57), and 2,6-diamino-3-[(pyridin-3-yl)azo]pyridine and their salts.

[0114] In certain embodiments, the cosmetic compositions described elsewhere herein comprise from 0.1% to 15% by weight, preferably from 0.1% to 10% by weight, and even more preferably from 0.5% to 8.0% by weight of at least one direct dye.

[0115] In certain embodiments, the cosmetic compositions described elsewhere herein contain fragrances or fragrance ingredients. Individual fragrance compounds, such as synthetic products of ester, ether, aldehyde, ketone, alcohol, and hydrocarbon types, can be used as fragrance oils or perfume oils. Examples of ester-type fragrance compounds include benzyl acetate, phenoxyethyl isobutyrate, p-tert-butylcyclohexyl acetate, linalyl acetate, dimethylbenzyl carbinyl acetate, phenylethyl acetate, linalyl benzoate, benzyl formate, ethyl-methylphenylglycinate, allyl cyclohexyl propionate, styrallyl propionate, and benzyl salicylate. The ethers include, for example, benzyl ethyl ether; the aldehydes include, for example, linear alkanals having 8 to 18 carbon atoms, such as citral, citronellal, citronellyloxyacetaldehyde, cyclamen aldehyde, hydroxycitronellal, lilial, and bourgeonal; the ketones include, for example, ionones, α-isomethylionone, and methyl-cedryl ketone; the alcohols include anethole, citronellol, eugenol, geraniol, linalool, phenylethyl alcohol, and terpineol; and the hydrocarbons mainly include terpenes and balsams. Preferably, a mixture of various fragrances is used, which together produce an attractive perfume note. Perfume oils can also contain mixtures of natural fragrance-producing substances obtained from plant or animal sources, such as pine oil, citrus oil, jasmine oil, lily oil, rose oil, or ylang-ylang oil. Low-volatility essential oils primarily used as flavoring ingredients, such as sage oil, chamomile oil, clove oil, melissa oil, peppermint oil, cinnamon leaf oil, linden flower oil, juniper berry oil, vetiver oil, olibanum oil, galbanum oil, and labdanum oil, are also suitable as perfume oils. In certain embodiments, the cosmetic compositions described elsewhere herein comprise 0.01% to 3.0% by weight, preferably 0.05% to 2.0% by weight, and even more preferably 0.1% to 1.0% by weight of at least one fragrance or fragrance ingredient.

[0116] In certain embodiments, the cosmetic compositions described elsewhere herein include a carrier, solvent, or diluent. In certain embodiments, the cosmetic compositions described elsewhere herein include a solvent, the solvent including water and / or alcohol. The solvent is useful for providing the compounds used in the present invention in liquid form. In certain embodiments, the solvent is cosmetically acceptable. In certain embodiments, the cosmetic compositions described elsewhere herein include at least 10% by weight of water. Water is useful for economic reasons, but also for cosmetically acceptable reasons. Optionally, the composition includes a water-miscible or water-soluble solvent, such as a lower alkyl alcohol. In certain embodiments, the cosmetic compositions described elsewhere herein include a C1-C5 alkyl monohydric alcohol, preferably a C2-C3 alkyl alcohol. The alcohol that may be present is, in particular, a lower monohydric or polyhydric alcohol having 1 to 4 carbon atoms commonly used for cosmetic purposes, such as, preferably, ethanol and isopropanol. Optionally, the composition includes a water-soluble polyhydric alcohol. In a particular embodiment, the water-soluble polyhydric alcohol is a polyhydric alcohol having two or more hydroxyl groups in the molecule. In certain embodiments, the water-soluble polyhydric alcohol is selected from the group consisting of dihydric alcohols such as ethylene glycol, propylene glycol, trimethylene glycol, 1,2-butylene glycol, 1,3-butylene glycol, 1,4-butylene glycol, tetramethylene glycol, 2,3-butylene glycol, pentamethylene glycol, 2-butene-1,4-diol, hexylene glycol, and octylene glycol; trihydric alcohols such as glycerin, trimethylolpropane, and 1,2,6-hexanetriol; tetrahydric alcohols such as pentaerythritol; pentahydric alcohols such as xylytol; hexahydric alcohols such as sorbitol and mannitol; and polyhydric alcohol polymers such as diethylene glycol, dipropylene glycol, polyethylene glycol, polypropylene glycol, tetraethylene glycol, diglycerin, polyethylene glycol, triglycerin, tetraglycerin, and polyglycerin.Dihydric alcohol alkyl ethers, such as ethylene glycol monomethyl ether, ethylene glycol monoethyl ether, ethylene glycol monobutyl ether, ethylene glycol monophenyl ether, ethylene glycol monohexyl ether, ethylene glycol mono-2-methylhexyl ether, ethylene glycol isoamyl ether, ethylene glycol benzyl ether, ethylene glycol isopropyl ether, ethylene glycol dimethyl ether, ethylene glycol diethyl ether, and ethylene glycol dibutyl ether; dihydric alcohol alkyl ethers, such as diethylene glycol monomethyl ether, diethylene glycol monoethyl ether, diethylene glycol monobutyl ether, diethylene glycol dimethyl ether, diethylene glycol diethyl ether, diethylene glycol butyl ether, diethylene glycol methyl ethyl ether, triethylene glycol monomethyl ether, triethylene glycol monoethyl ether, and propylene glycol dihydric alcohol ether esters, such as ethylene glycol monomethyl ether acetate, ethylene glycol monoethyl ether acetate, ethylene glycol monobutyl ether acetate, ethylene glycol monophenyl ether acetate, ethylene glycol diadipate, ethylene glycol disuccinate, diethylene glycol monoethyl ether acetate, diethylene glycol monobutyl ether acetate, propylene glycol monomethyl ether acetate, propylene glycol monoethyl ether acetate, propylene glycol monopropyl ether acetate, propylene glycol monophenyl ether acetate; glycerin monoalkyl ethers, such as xyl alcohol, selachyl alcohol, and batyl alcohol;Sugar alcohols, such as sorbitol, maltitol, maltotriose, mannitol, sucrose, erythritol, glucose, fructose, starch sugars, maltose, xylytose, starch sugar reducing alcohols, glysolid, tetrahydrofurfuryl alcohol, POE tetrahydrofurfuryl alcohol, POP butyl ether, POP POE butyl ether, tripolyoxypropylene glycerin ether, POP glycerin ether, POP glycerin ether phosphate, POP POE pentanerythritol ether, and mixtures thereof. In a preferred embodiment, the composition comprises a solvent selected from the group consisting of water, glycol, ethanol, and combinations thereof. In a preferred embodiment, the composition comprises an aqueous, alcoholic or aqueous-alcoholic solvent, the aqueous, alcoholic or aqueous-alcoholic solvent comprising water, ethanol, propanol, isopropanol, 1,2-propylene glycol, 1,3-propylene glycol, isobutanol, butanol, butyl glycol, butyl diglycol, glycerol, or a mixture thereof; preferably, the aqueous, alcoholic or aqueous-alcoholic solvent comprises water, ethanol, propanol, isopropanol, 1,2-propylene glycol, 1,3-propylene glycol, glycerol, or a mixture thereof; more preferably, the aqueous, alcoholic or aqueous-alcoholic solvent comprises water, isopropanol, 1,2-propylene glycol, 1,3-propylene glycol, or a mixture thereof;Even more preferably, the aqueous, alcoholic, or aqueous-alcoholic solvent consists of water or a mixture of water and alcohol, wherein the alcohol is selected from the group consisting of isopropanol, 1,2-propylene glycol, and 1,3-propylene glycol. Natural solvents can also be used. In certain embodiments, the cosmetic compositions described elsewhere herein comprise a solvent selected from the group consisting of vegetable oils, honey, vegetable sugar compositions, and mixtures thereof. In certain embodiments, the cosmetic compositions described elsewhere herein comprise 0.5% to 90% by weight, preferably 1.0% to 80% by weight, and even more preferably 5.0% to 70% by weight, of at least one carrier, solvent, and / or diluent.

[0117] In certain embodiments, the cosmetic compositions described elsewhere herein contain a propellant. In certain embodiments, the propellant is selected from compressed gas propellants and liquefied gas propellants. In certain embodiments, the compressed gas propellant is selected from the group consisting of air, nitrogen (N), nitrous oxide (N), carbon dioxide (CO), and mixtures thereof; preferably air, nitrogen (N), and mixtures thereof; most preferably nitrogen (N). In certain embodiments, the liquefied gas propellant is selected from the group consisting of dimethyl ether (DME), 1,1-difluoroethane (HFC-152a), 1,1,1,2-tetrafluoroethane (HFC-134a), pentane, n-butane, isobutane, propane, trans-1,3,3,3-tetrafluoropropene (HF0-1234ze), and mixtures thereof, preferably dimethyl ether (DME), 1,1-difluoroethane (HFC-152a), and mixtures thereof. In preferred embodiments, the propellant is selected from the group consisting of nitrogen, carbon dioxide, pentane, n-butane, isobutane, propane, and combinations thereof. In certain embodiments, the cosmetic compositions described elsewhere herein comprise from 0.5% to 60% by weight, preferably from 1.0% to 50% by weight, and even more preferably from 2.0% to 40% by weight of at least one propellant.

[0118] In certain embodiments, the cosmetic compositions described elsewhere herein contain functional acids or active ingredients. Functional acids and active ingredients are substances used to impart clinical functionality to skin or hair upon application. Functional acids and active ingredients are used, for example, as exfoliants, skin brighteners, self-tanning agents, anti-acne agents, and anti-aging agents. In another preferred embodiment of the present invention, the composition according to the present invention contains one or more hydroxy acids, particularly preferably one or more substances selected from α- and β-hydroxy acids. The composition according to the present invention may contain, as the hydroxy acid, preferably lactic acid, glycolic acid, salicylic acid, alkylated salicylic acid, or citric acid. Furthermore, the formulation according to the present invention may contain other acidic ingredients. As active ingredients, the following may be considered: tartaric acid, mandelic acid, caffeic acid, pyruvic acid, oligo-oxamono- and dicarboxylic acids, fumaric acid, retinoic acid, sulfonic acids, benzoic acid, kojic acid, fruit acids, malic acid, gluconic acid, pyruvic acid, galacturonic acid, ribonic acid, hyaluronic acid and all their derivatives, polyglycol diacids in free or partially neutralized form, vitamin C (ascorbic acid), vitamin C derivatives (e.g. sodium ascorbyl phosphate, magnesium ascorbyl phosphate and magnesium ascorbyl glucoside), glucoside), dihydroxyacetone, minoxidil, proteolytic enzymes (e.g., fruit enzymes from papaya, pumpkin, and pineapple, such as papainase and bromelain ananase), caffeine, niacinamide and its derivatives, diethyltoluamide (DEET), or skin-lightening actives, such as arbutin or glycyrrhetinic acid and its salts, glutathione, cysteine, resveratrol, 4-butylresorcinol, or plant extracts such as pancratium maritimum extract or mulberry extract. In a preferred embodiment, the functional acid and / or active ingredient is selected from the group consisting of salicylic acid, kojic acid, hyaluronic acid, ascorbic acid and all their derivatives, dihydroxyacetone, arbutin, and combinations thereof.In certain embodiments, the cosmetic compositions described elsewhere herein comprise from 0.05% to 15% by weight, preferably from 0.1% to 10% by weight, and even more preferably from 0.5% to 5.0% by weight of at least one functional acid and / or active ingredient.

[0119] In certain embodiments, the cosmetic compositions described elsewhere herein include a deodorant or antiperspirant. In certain embodiments, the cosmetic compositions described elsewhere herein include a deodorant. In certain embodiments, the deodorant is selected from the group consisting of allantoin, bisabolol, and combinations thereof. In certain embodiments, the cosmetic compositions described elsewhere herein include 0.001% to 10% by weight, or 0.01% to 9.0% by weight, or 0.05% to 8.0% by weight, or 0.1% to 5.0% by weight of at least one deodorant. The composition may include an antiperspirant. Examples of the antiperspirant that can be used include aluminum chloride, aluminum chloride hydroxide, aluminum chloride dihydroxide, aluminum chlorohydrex polyethylene glycol complex, magnesium zirconium complex, and aluminum zirconium chloride hydroxide. In certain embodiments, the cosmetic compositions described elsewhere herein comprise from 0.001% to 10% by weight, or from 0.01% to 9.0% by weight, or from 0.05% to 8.0% by weight, or from 0.1% to 5.0% by weight of at least one antiperspirant.

[0120] In certain embodiments, the cosmetic compositions described elsewhere herein contain at least one viscosity modifier or thickener and / or gelling agent. The desired viscosity and rheological profile of the composition can be adjusted by adding additional thickeners and gelling agents. The viscosity modifier is preferably a thickening polymer. In certain embodiments, the thickening polymer is selected from the group consisting of copolymers of at least one first monomer type selected from acrylic acid and methacrylic acid and at least one second monomer type selected from acrylic acid and esters of ethoxylated fatty alcohols, crosslinked polyacrylic acid, ... crosslinked polyacrylic acid, copolymers of at least one first monomer type selected from acrylic acid and methacrylic acid and at least one second monomer type selected from acrylic acid and esters of ethoxylated fatty alcohols, crosslinked polyacrylic acid, crosslinked polyacrylic acid, crosslinked polyacrylic acid, crosslinked polyacrylic acid, crosslinked polyacrylic acid, crosslinked polyacrylic acid, crosslinked polyacrylic acid, crosslinked polyacrylic acid, crosslinked polyacrylic acid, crosslinked polyacrylic acid, crosslinked polyacrylic acid, crosslinked polyacrylic acid, crosslinked polyacrylic acid, crosslinked polyacrylic acid, crosslinked polyacrylic acid, crosslinked polyacrylic acid, crosslinked polyacrylic acid, crosslinked polyacrylic acid, 10 -~C 30 -crosslinked copolymers with at least one second monomer type selected from esters of alcohols; copolymers of at least one first monomer type selected from acrylic acid and methacrylic acid with at least one second monomer type selected from esters of itaconic acid and ethoxylated fatty alcohols; copolymers of at least one first monomer type selected from acrylic acid and methacrylic acid with at least one second monomer type selected from esters of itaconic acid and ethoxylated fatty alcohols 10 -~C 30copolymers of at least one second monomer type selected from esters of hydroxypropyl acrylates and esters of hydroxypropyl acrylates with a third monomer type selected from C1- to C4-aminoalkyl acrylates; copolymers of two or more monomers selected from acrylic acid, methacrylic acid, acrylic acid esters and methacrylic acid esters; copolymers of vinylpyrrolidone and ammonium acryloyldimethyltaurate; copolymers of ammonium acryloyldimethyltaurate and monomers selected from esters of methacrylic acid and ethoxylated fatty alcohols, hydroxyethyl cellulose, hydroxypropyl cellulose, hydroxypropyl guar, glycerin, Examples of suitable viscosity modifiers include acrylate polyacrylate, glyceryl polymethacrylate, copolymers of at least one C2-, C3-, or C4-alkylene with styrene, polyurethane, hydroxypropyl starch phosphate, polyacrylamide, copolymers of maleic anhydride and methyl vinyl ether crosslinked with decadiene, carob seed flour, gums such as guar gum, karaya gum, xanthan gum, or dehydroxanthan gum, carrageenan, hydrolyzed corn starch, polyethylene oxide, copolymers of fatty alcohols and saturated methylene diphenyl diisocyanate (e.g., PEG-150 / stearyl alcohol / SMDI copolymer), and mixtures thereof. In a preferred embodiment, the viscosity modifier or thickener and / or gelling agent is selected from the group consisting of carbomer, acrylate copolymer, xanthan gum, hydroxyethyl cellulose, laureth-2, and combinations thereof. In certain embodiments, the cosmetic compositions described elsewhere herein comprise from 0.01% to 15% by weight, preferably from 0.1% to 10% by weight, and even more preferably from 0.5% to 5.0% by weight of at least one viscosity modifier or thickener and / or gelling agent.

[0121] In certain embodiments, the cosmetic compositions described elsewhere herein contain an alkalizing agent or pH adjuster. In certain embodiments, ammonia or caustic soda are suitable, but water-soluble physiologically acceptable salts of organic and inorganic bases can also be considered. Optionally, the pH adjuster is selected from ammonium bicarbonate, ammonia, monoethanolamine, ammonium hydroxide, and ammonium carbonate. In certain embodiments, the alkalizing agent is selected from the group consisting of 2-amino-2-methyl-1-propanol, 2-amino-2-methyl-1,3-propanediol, 2-amino-2-ethyl-1,3-propanediol, tris(hydroxyl-methyl)-aminomethane, 2-amino-1-butanol, tris(2-hydroxypropyl)-amine, 2,2-iminobisethanol, lysine, iminourea (guanidine carbonate), tetrahydro-1,4-oxazine, 2-amino-5-guanidine-valeric acid, 2-aminoethanesulfonic acid, diethanolamine, triethanolamine, N-methylethanolamine, isopropanolamine, diisopropanolamine, triisopropanolamine, glucamine, sodium hydroxide, potassium hydroxide, lithium hydroxide and magnesium oxide, and mixtures thereof.Acid can be included to establish an acidic pH value. In certain embodiments, the cosmetic compositions described elsewhere herein contain an acid selected from the group consisting of hydrochloric acid, phosphoric acid, acetic acid, formic acid, sulfuric acid, hydrochloric acid, citric acid, ascorbic acid, and mixtures thereof. Citric acid is most preferred due to its high consumer acceptance. In certain embodiments, the acidic pH is adjusted with a buffer, such as a phosphate buffer, a TRIS buffer, or a citrate buffer. The buffer may be used alone or in combination with an acid. In preferred embodiments, the alkalizing agent or pH adjuster is selected from the group consisting of triethanolamine, sodium hydroxide, lactic acid, citric acid, and combinations thereof. In certain embodiments, the cosmetic compositions described elsewhere herein contain 0.001% to 5.0% by weight, preferably 0.01% to 3.0% by weight, and even more preferably 0.1% to 1.0% by weight of at least one alkalizing agent or pH adjuster.

[0122] In certain embodiments, the composition / formulation comprises an antioxidant, wherein the antioxidant is selected from the group consisting of amino acids, peptides, sugars, imidazole, carotinoids, carotene, chlorogenic acid, lipoic acid, thiols, thiol glycosyl esters, thiol N-acetyl esters, thiol methyl esters, thiol ethyl esters, thiol propyl esters, thiol amyl esters, thiol butyl esters, thiol lauryl esters, thiol palmitoyl esters, thiol oleyl esters, thiol linoleyl esters, thiol cholesteryl esters, thiol glyceryl esters, dilauryl thiodipropionate, distearyl thiodipropionate, thiodipropionic acid, metal chelators, hydroxy acids, fatty acids, folic acid, vitamin C, tocopherol, vitamin A, stilbene, derivatives thereof, and combinations thereof. In certain embodiments, the antioxidant is selected from the group consisting of glycine, histidine, tyrosine, tryptophan, urocaninic acid, D,L-carnosine, D-carnosine, L-carnosine, β-carotene, α-carotene, lycopene, dihydrolipoic acid, aurothioglucose, propylthiouracil, thioredoxin, glutathione, cysteine, cystine, cystamine, buthionine sulfoximine, homocysteine ​​sulfoximine, buthionine sulfone, penta-, hexa-, heptathionine sulfoximine, hydroxy fatty acids, palmitic acid, phytanic acid, acid), lactoferrin, citric acid, lactic acid, malic acid, humic acid, bile acids, bilirubin, biliverdin, EDTA, EGTA, linoleic acid, linolenic acid, oleic acid, butylhydroxyanisole, trihydroxybutyrophenone, ubiquinone, ubiquinol, ascorbyl palmitate, Mg-ascorbyl phosphate, ascorbyl acetate, vitamin E acetate, vitamin A palmitate, carnosine, mannose, ZnO, ZnSO4, selenium methionine, stilbene, superoxide dismutase, and combinations thereof.In certain embodiments, the antioxidant is selected from the group consisting of vitamin A, vitamin A derivatives, vitamin E, vitamin E derivatives, and combinations thereof. In certain embodiments, the cosmetic compositions described elsewhere herein comprise 0.001% to 10% by weight, preferably 0.05% to 5.0% by weight, even more preferably 0.1% to 3.0% by weight, and most preferably 0.05% to 1.0% by weight of at least one antioxidant.

[0123] In certain embodiments, the composition / formulation comprises a chelating agent. In certain embodiments, the chelating agent is selected from the group consisting of EDTA, caprylhydroxamic acid, oxalate derivatives, disodium hydroxyethyliminodiacetate, galacturonic acid and derivatives, glucuronic acid and derivatives, lauroylethylenediaminetriacetic acid, methyl dihydroxybenzoate, trisodium ethylenediaminedisuccinate, phytic acid, itaconic acid, propanetricarboxylic acid, citric acid and derivatives (e.g., diammonium citrate, bismuth citrate, and acetyltrihexyl citrate 2,6-dicarboxypyridine), phosphoric and phosphonic acid derivatives (e.g., diethylenetriaminepentamethylenephosphonic acid, disodium azacycloheptanediphosphonate, glycereth-26 phosphate, disodium pyrophosphate, disodium salicylic phosphate, aminotrimethylenephosphonic acid, phosphonobutanetricarboxylic acid, potassium trisphosphonomethylamine oxide, β-alaninediacetic acid, or cyclohexanediaminetetraacetic acid). In certain embodiments, the chelating agent is selected from the group consisting of EDTA, oxalate derivatives, disodium salicylate phosphate, and combinations thereof. In certain embodiments, the cosmetic compositions described elsewhere herein comprise 0.01% to 2.0% by weight, preferably 0.05% to 1.5% by weight, even more preferably 0.1% to 1.0% by weight, and most preferably 0.05% to 1.0% by weight of at least one chelating agent.

[0124] In certain embodiments, the cosmetic compositions described elsewhere herein comprise an astringent. In certain embodiments, the astringent is selected from the group consisting of magnesium oxide, aluminum oxide, titanium dioxide, zirconium dioxide, zinc oxide, oxide hydrates, aluminum oxide hydrate (boehmite), and hydroxides, calcium, magnesium, aluminum, titanium, zirconium, or zinc chlorohydrates. In certain embodiments, the cosmetic compositions described elsewhere herein comprise 0.001% to 10% by weight, or 0.01% to 9.0% by weight, or 0.05% to 8.0% by weight, or 0.1% to 5.0% by weight of at least one astringent.

[0125] In certain embodiments, the cosmetic compositions described elsewhere herein contain sunscreens and / or UV-blocking agents. Suitable sunscreens and UV-blocking agents are disclosed in WO2013017262A1 (published February 7, 2013), from page 32, line 11 to the end of page 33. Photoprotective agents include, in particular, all of the photoprotective agents identified in EP1084696A1 (incorporated herein by reference). In another preferred embodiment of the present invention, the composition according to the present invention contains one or more substances selected from inorganic and organic UV-blocking agents, and is particularly preferably in the form of a sunscreen composition.

[0126] The compositions according to the invention may contain particulate titanium dioxide, mica-titanium dioxide, iron oxide, mica-iron oxide, zinc oxide, silicon oxide, ultramarine or chromium oxide as pigments / micropigments and inorganic sunscreen and / or UV blocking agents. Organic sunscreen or UV blocking agents are preferably 4-aminobenzoic acid, 3-(4'-trimethylammonium)-benzylidene-bornan-2-one-methylsulfate, camphorbenzalkonium methosulfate, 3,3,5-trimethyl-cyclohexyl salicylate, 2-hydroxy-4-methoxybenzophenone, 2-phenylbenzimidazole-5-sulfonic acid and their potassium, sodium and triethanolamine salts, 3,3'-(1,4-phenylenedimethine)-bis(7,7-dimethyl-2-oxobicyclo[4.2.1.2]methyl]propanol, 2,3'-bis(2,3'-dimethyl-2,3'-propanol), ... [2.2.1]-heptane-1-methanesulfonic acid) and their salts, 1-(4-tert-butylphenyl)-3-(4-methoxyphenyl)propane-1,3-dione, 3-(4'-sulfo)-benzylidene-bornan-2-one and their salts, 2-cyano-3,3-diphenylacrylic acid-(2-ethylhexyl ester), polymer of N-[2(and 4)-(2-oxoborn-3-ylidenemethyl)benzyl]-acrylamide, 4-methoxy-cinnamic acid-2-ethylhexyl ester, ethoxylated ethyl-4-aminobenzoate, 4-methoxy-cinnamic acid isoamyl ester, 2,4 ,6-tris-[p-(2-ethylhexyloxycarbonyl)anilino]-1,3,5-triazine, 2-(2H-benzotriazol-2-yl)-4-methyl-6-(2-methyl-3-(1,3,3,3-tetramethyl-1-(trimethylsilyloxy)-disiloxanyl)-propyl)phenol, 4,4'-[(6-[4-((1,1-dimethylethyl)-aminocarbonyl)phenylamino]-1,3,5-triazin-2,4-yl)diimino]bis-(benzoic acid-2-ethylhexyl ester), benzophenone-3, benzophenone-4 (acid), 3-(4'-methylbenzylidene)-D,L-camphor, 3-benzylidene-camphor, salicylic acid-2-ethylhexyl ester, 4-dimethylaminobenzoic acid-2-ethylhexyl ester, hydroxy-4-methoxy-benzophenone-5-sulfonic acid (sulfisobenzonam) and their salts, 4-isopropylbenzyl salicylate, N,N,N-trimethyl-4-(2-oxoborn-3-ylidenemethyl)anilium methyl sulfate, homosalate (INN), oxybenzone (INN) ), 2-phenylbenzimidazole-5-sulfonic acid and their sodium, potassium and triethanolamine salts, octyl methoxycinnamic acid, isopentyl-4-methoxycinnamic acid, isoamyl-p-methoxycinnamic acid, 2,4,6-trianilino-(p-carbo-2'-ethylhexyl-1'-oxy)-1,3,5-triazine (octyltriazone) phenol, 2-(2H-benzotriazol-2-yl)-4-methyl-6-(2-methyl-3-(1, 3,3,3-Tetramethyl-1-(trimethylsilyl)oxy)-disiloxanyl)propyl(drometrizoletrisiloxane)benzoate, 4,4-((6-(((1,1-dimethylethyl)amino)carbonyl)phenyl)amino)-1,3,5-triazine-2,4-diyl)diimino)bis,bis(2-ethylhexyl)ester)benzoate, 4,4-((6-(((1,1-dimethylethyl)amino)-carbonyl)phenyl)amino)-1,3,5-triazine (2,4-diyl)diimino)bis, bis(2-ethylhexyl) ester), 3-(4'-methylbenzylidene)-D,L-camphor (4-methylbenzylidene camphor), benzylidene-camphor-sulfonic acid, octocrylene, polyacrylamidomethyl-benzylidene-camphor, 2-ethylhexyl salicylate (octyl salicylate), 4-dimethyl-aminobenzoic acid ethyl-2-hexyl ester (octyldimethyl PABA), PEG-25 PABA, 2-hydroxy-4-methoxybenzophenone-5-sulfonic acid (benzophenone-5) and Na salt, 2,2'-methylene-bis-6-(2H-benzotriazol-2-yl)-4-(tetramethylbutyl)-1,1,3,3-phenol, 2-2'-bis-(1,4-phenylene)1H-benzimidazole-4,Sodium salt of 6-disulfonic acid, (1,3,5)-triazine-2,4-bis((4-(2-ethylhexyloxy)-2-hydroxy)-phenyl)-6-(4-methoxyphenyl), 2-ethylhexyl-2-cyano-3,3-diphenyl-2-propenoate, glyceryl octanoate di-p-methoxycinnamic acid, p-amino-benzoic acid and their esters, 4-tert-butyl-4'-methoxydibenzoylmethane, 4-(2-β-glucopyranoxy)propanol Disodium salt of 2,2'-dihydroxy-4,4'-dimethoxy-5,5'-disulfobenzophenone, dihydroxybenzophenone, 1,3,4-dimethoxyphenyl-4,4-dimethyl-1,3-pentanedione, 2-ethylhexyl-dimethoxybenzylidene-dioxoimidazolidinepropionate, 2,2'-dihydroxy-4,4'-dimethoxy-5,5'-disulfobenzophenone ... nate, methylene-bis-benzotriazolyl tetramethylbutylphenol, phenyl dibenzimidazole tetrasulfonate, bis-ethylhexyloxyphenol-methoxyphenol-triazine, tetrahydroxybenzophenone, terephthalidene-dicamphor-sulfonic acid, 2,4,6-tris[4,2-ethylhexyloxycarbonyl)anilino]-1,3,5-triazine, methyl-bis(trimethylsiloxy)silyl-isopentyltrimethoxycinnamate, amyl-p-dimethylaminobenzoate, amyl-p-dimethylaminobenzoate, 2-ethylhexyl-p-dimethylaminobenzoate, isopropyl-p-methoxycinnamate / diisopropyl cinnamate, 2-ethylhexyl-p-methoxycinnamic acid, 2-hydroxy-4-methoxybenzophenone, 2-hydroxy-4-methoxybenzophenone-5-sulfo acid) and trihydrate, and 2-hydroxy-4-methoxybenzophenone-5-sulfonate sodium salt, phenyl-benzimidazole-sulfonic acid, p-aminobenzoic acid butyl ester, methyl-3-[2,4-bis(methylethyl)phenyl]-2-propenoate, 3-(4-hydroxy-3-methoxyphenyl)-2-propenoic acid, 5-methyl-2-(1-methylethyl)cyclohexanol-2-aminobenzoate, diethylmalonylbenzylideneoxypropene dimethicone, 2,4,6-tris(biphenyl-4-yl)-1,3,5-triazine, and tris(2-hydroxyethyl)ammonium 2-hydroxybenzoate. In a preferred embodiment, the sunscreen and / or UV blocker is selected from the group consisting of 2-ethylhexyl 4-methoxycinnamate, methyl methoxycinnamate, 2-ethylhexyl salicylate, 2-ethylhexyl-2-cyano-3,3-diphenyl-2-propenoate, 2-hydroxy-4-methoxybenzophenone-5-sulfonic acid, polyethoxylated p-aminobenzoate, and combinations thereof. In certain embodiments, the cosmetic compositions described elsewhere herein comprise from 0.001% to 30% by weight, preferably from 0.05% to 20% by weight, even more preferably from 0.1% to 10% by weight, and most preferably from 0.05% to 5.0% by weight of at least one sunscreen and / or UV blocker.

[0127] In certain embodiments, the cosmetic composition described elsewhere herein comprises a skin conditioning agent.Skin conditioning agents, such as emollients, moisturizing agents, and skin protectants, are ingredients that help maintain the soft and smooth appearance of skin or help improve the condition of dry or damaged skin.In certain embodiments, the skin conditioning agent is selected from the group consisting of oils (see above), functional acids or active ingredients (see above), fatty acid N-alkyl polyhydroxyalkylamides, fatty acids, triglycerides, panthenol, allantoin, bisabolol, glycerol, sorbitol, urea and its derivatives, trehalose, erythrulose, pyrrolidone carboxylic acid (PCA) and its salts, polyglucuronic acid, gluconolactone, petrolatum, ubiquinone-10, and ubiquinol.In a preferred embodiment, the skin conditioning agent is selected from the group consisting of urea, glycerin, pyrrolidone carboxylic acid (PCA) and its salts, panthenol, petrolatum, and combinations thereof. In certain embodiments, the cosmetic compositions described elsewhere herein comprise from 0.001% to 5.0% by weight, preferably from 0.05% to 3.0% by weight, and even more preferably from 0.1% to 1.0% by weight of at least one skin conditioning agent.

[0128] In certain embodiments, the cosmetic compositions described elsewhere herein contain an antifoaming agent. An antifoaming agent is a chemical that reduces the tendency of a final product to generate foam when shaken or stirred. In certain embodiments, the antifoaming agent is selected from the group consisting of alcohols (e.g., ethanol, isopropyl alcohol, or propyl alcohol), alkoxylated alcohols (e.g., laureth-5 butyl ether), silicone oils and resins (e.g., dimethicone and its derivatives, such as cetyl dimethicone, phenyl dimethicone, PEG / PPG-12 / 18 dimethicone and hydrogen trifluoropropyl dimethicone, trimethylsiloxysilicate / dimethicone crosspolymer, or polysilicone-10), and hydrophobic silica derivatives (e.g., silica silylate). In a preferred embodiment, the antifoaming agent is selected from the group consisting of ethanol, dimethicone, silica silylate, and combinations thereof. In certain embodiments, the cosmetic compositions described elsewhere herein comprise from 0.01% to 5.0% by weight, preferably from 0.1% to 3.0% by weight, and even more preferably from 0.5% to 2.0% by weight of at least one anti-foaming agent.

[0129] In certain embodiments, the cosmetic compositions described elsewhere herein include a flavoring agent. In certain embodiments, the flavoring agent is 1-acetonaphthalene, 1-decen-3-ol, p-methylbenzaldehyde, p-propenylphenyl methyl ether, aspartame, benzaldehyde, bromocinnamal, calcium cyclohexylsulfamate, o-benzolufimide, carvone, cinnamaldehyde, 3,7-dimethyl-6-octenoic acid, fructose, glucose, glucosylstevioside, honey, 3-methyl-1-butanol, 4-hydroxy-3-methoxy-1-propenylbenzene, maltose, menthol, eucalyptol, thymol, potassium 6-methyl-1,2,2-oxathiazin-4(3H)-one. The flavoring agent is selected from the group consisting of 2,2'-dioxide, isodulcitol, saccharin, stevioside, 1',4,6'-trichloro-galacto-sucrose, sorbitol, saccharose, saccharin sodium, methyl salicylate, vanillaldehyde, xylitol, xylose, and plant extracts. In a preferred embodiment, the flavoring agent is selected from the group consisting of benzaldehyde, cinnamaldehyde, fructose, stevioside and its derivatives, saccharin, saccharose, vanillaldehyde, xylitol, and combinations thereof. In certain embodiments, the cosmetic compositions described elsewhere herein comprise 0.001% to 3.0% by weight, preferably 0.01% to 2.0% by weight, and even more preferably 0.05% to 1.0% by weight of at least one flavoring agent.

[0130] In certain embodiments, the cosmetic compositions described elsewhere herein contain electrolytes. In certain embodiments, the electrolyte is selected from the group consisting of salts, preferably ammonium or metal salts, particularly preferably halides, such as CaCl, MgCl, LiCl, KCl, and NaCl, carbonates, bicarbonates, phosphates, sulfates, nitrates, particularly preferably sodium chloride, sodium fluoride, sodium monofluorophosphate, stannous fluoride, and / or organic salts, preferably ammonium or metal salts (particularly preferably glycolic acid, lactic acid, citric acid, tartaric acid, mandelic acid, salicylic acid, ascorbic acid, pyruvic acid, fumaric acid, retinoic acid, sulfonic acid, benzoic acid, kojic acid, fruit acids, malic acid, gluconic acid, or galacturonic acid). These also include aluminum salts, preferably aluminum hydrochloride or aluminum-zirconium complex salts. Therefore, in a preferred embodiment of the present invention, the composition according to the present invention contains one or more substances selected from inorganic salts and organic salts. As an electrolyte, the composition according to the present invention may also contain a mixture of various salts. In a preferred embodiment, the electrolyte is selected from the group consisting of sodium chloride, magnesium chloride, sodium citrate, sodium acetate, sodium hyaluronate, and combinations thereof. In certain embodiments, the cosmetic compositions described elsewhere herein contain 0.001% to 5.0% by weight, preferably 0.05% to 3.0% by weight, and even more preferably 0.1% to 1.0% by weight of at least one electrolyte.

[0131] In certain embodiments, the cosmetic compositions described elsewhere herein contain an oxidizing or reducing agent. In certain embodiments, the oxidizing or reducing agent is selected from the group consisting of ammonium persulfate, calcium peroxide, hydrogen peroxide, hypochlorous acid, sodium hypochlorite, potassium monopersulfate, sodium carbonate peroxide, ammonium thioglycolate, cysteine, glutathione, hydroquinone, mercaptopropionic acid, superoxide dismutase, thioglycerin, thioglycolic acid, thiolactic acid, sodium sulfite, sodium thioglycolate, potassium thioglycolate, and cysteine, and the compositions according to the present invention may also contain mixtures of various agents. In a preferred embodiment, the oxidizing or reducing agent is selected from the group consisting of hydrogen peroxide, sodium hypochlorite, superoxide dismutase, thioglycolic acid, sodium thioglycolate, potassium thioglycolate, cysteine, sodium carbonate peroxide, and combinations thereof. In certain embodiments, the cosmetic compositions described elsewhere herein comprise from 0.001% to 10% by weight, preferably from 0.05% to 7.0% by weight, and even more preferably from 0.1% to 5.0% by weight of at least one oxidizing or reducing agent.

[0132] Composition properties The cosmetic compositions of the present disclosure, as described elsewhere herein, may have beneficial properties in certain embodiments. For example, in certain embodiments, the cosmetic composition has a viscosity of 0 cPs to 20,000 cPs. In particular embodiments, the cosmetic composition has a viscosity of 0.1 cPs to 10,000 cPs, or 1 cPs to 5,000 cPs, or 5 cPs to 3,500 cPs. Viscosity measurement conditions are defined in the definitions section above. Viscosity may be important for preventing dripping, which may be inconvenient for the user. Furthermore, more viscous compositions may be useful for dispensing at a consistent rate. In certain embodiments, the cosmetic composition has a viscosity of 0 cPs to 1,000 cPs. This viscosity range is advantageous when the composition is in the form of a facial cleanser, in terms of the need for distribution on the skin and the ability to rinse off.

[0133] In certain embodiments, the cosmetic compositions described elsewhere herein further comprise a viscosity modifier. The viscosity modifier is preferably a thickening polymer. In certain embodiments, the thickening polymer is selected from the group consisting of: copolymers of at least one first monomer type selected from acrylic acid and methacrylic acid and at least one second monomer type selected from acrylic acid and esters of ethoxylated fatty alcohols; crosslinked polyacrylic acid; copolymers of at least one first monomer type selected from acrylic acid and methacrylic acid and acrylic acid and C 10 -~C 30 -crosslinked copolymers with at least one second monomer type selected from esters of alcohols; copolymers of at least one first monomer type selected from acrylic acid and methacrylic acid with at least one second monomer type selected from esters of itaconic acid and ethoxylated fatty alcohols; copolymers of at least one first monomer type selected from acrylic acid and methacrylic acid with at least one second monomer type selected from esters of itaconic acid and ethoxylated fatty alcohols 10 -~C 30-copolymers of at least one second monomer type selected from esters of alcohols and a third monomer type selected from C1- to C4-aminoalkyl acrylates; copolymers of two or more monomers selected from acrylic acid, methacrylic acid, acrylic acid esters and methacrylic acid esters; copolymers of vinylpyrrolidone and ammonium acryloyldimethyltaurate; copolymers of ammonium acryloyldimethyltaurate and monomers selected from esters of methacrylic acid and ethoxylated fatty alcohols; hydroxyethyl cellulose; hydroxypropyl cellulose; hydroxypropyl glycol ar; glyceryl polyacrylate; glyceryl polymethacrylate; copolymers of at least one C2-, C3-, or C4-alkylene with styrene; polyurethane; hydroxypropyl starch phosphate; polyacrylamide; copolymers of maleic anhydride and methyl vinyl ether crosslinked with decadiene; carob seed flour; guar gum; xanthan; dehydroxanthan; carrageenan; karaya gum; hydrolyzed corn starch; copolymers of polyethylene oxide, fatty alcohols, and saturated methylene diphenyl diisocyanate (e.g., PEG-150 / stearyl alcohol / SMDI copolymer), and mixtures thereof.

[0134] In certain embodiments, the cosmetic composition has a pH value ranging from 2.0 to 12.0, or from 3.0 to 9.0, or from 4.5 to 7.5, or from 2.0 to 7.0, or from 3.0 to 7.0, or from 4.5 to 7.0, or from pH 4 to pH 6.5, or from pH 4 to pH 6, or from pH 4.5 to pH 6.5, or from pH 4.5 to pH 6, or from pH 5.3 to pH 5.7, or from pH 5 to pH 6, or a pH of about 5.5. By varying the pH value, cosmetic compositions suitable for different uses can be provided.

[0135] In certain embodiments, the cosmetic composition is in liquid form. In alternative embodiments, the cosmetic composition is in solid form. Optionally, the cosmetic composition is in powder or granular form. This is advantageous in that it eliminates the need to transport the weight of liquid over long distances, which has economic and environmental benefits. A solid form can be achieved by spray-drying the composition or using a rotary evaporator. The composition can be converted to a liquid form after transportation, for example, by adding water. Transparency: A transparent composition is useful in terms of increasing consumer acceptance.

[0136] Composition Type The cosmetic compositions of the present disclosure, as described elsewhere herein, include various types depending on the end use. For example, in certain embodiments, the cosmetic compositions are available in a variety of formulations, including shampoos, conditioners (e.g., leave-in or rinse-out), body washes, facial cleansers, face masks, bubble baths, intimate washes, and the like. wash, bath oil, cleansing emulsion, micellar water, makeup remover, cleansing wipes, hair mask, fragrance, liquid soap, shaving soap, shaving foam, cleansing foam, day cream, anti-aging cream, body milk, body lotion, in-shower body lotion (i.e. no-rinse body lotion), body mousse, face serum, eye cream, sunscreen lotion, sun cream, facial cream, aftershave lotion, pre-shave cream, hair removal cream, skin whitening gel, self-tanning cream, anti-acne gel, mascara, foundation, primer, concealer, blush, bronzer, blemish balm (BB) cream, eyeliner, night cream, eyebrow gel, highlighter, lip stain, hand sanitizer, hair oil, nail polish remover, conditioner, hair styling gel, hair styling cream, anti-frizz serum serum), scalp treatment, hair colorant, hair removal fluid, deodorant, antiperspirant, baby cream, insect repellent, hand cream, sunscreen gel, foot cream, exfoliator, body scrub, cellulite treatment, bar soap, cuticle cream, lip balm, hair treatment, eye shadow, bath additive, body mist, eau de toilette, mouthwash, toothpaste, lubricating gel, moisturizer, serum, toner, aqua sorbet, cream gel, styling mousse, dry shampoo, lipstick, lip gloss, aqueous-alcoholic gel, body oil, shower milk, illuminator, lip crayon, hairspray, combing cream and sunblock.

[0137] Preferably, the composition is a shampoo, a conditioner (e.g., leave-in or rinse-out), a body wash, a facial cleanser, a face mask, a bubble bath, a cleansing emulsion, a micellar water, a makeup remover, a cleansing wipe, a hair mask, a liquid soap, a shaving soap, a shaving foam, a cleansing foam, a day cream, an anti-aging cream, a body milk, a body lotion, an in-shower body lotion The skincare product is selected from the group consisting of a body mousse, a face serum, an eye cream, a sunscreen lotion, a sun cream, a facial cream, an aftershave lotion, a pre-shave cream, a hair removal cream, a skin whitening gel, a self-tanning cream, an anti-acne gel, a hair oil, a conditioner, a hair styling gel, a hair styling cream, an anti-frizz serum, a scalp treatment, a hair colorant, a hair removal fluid, a deodorant, an antiperspirant, a baby cream, an insect repellent, a hand cream, a sunscreen gel, a foot cream, an exfoliator, a body scrub, a bar soap, a hair treatment, a mouthwash, a toothpaste, a moisturizer, a serum, a toner, an aqua sorbet, a cream gel, a styling mousse, an aqueous-alcoholic gel, a body oil, a shower milk, a hairspray, a combing cream, and a sunblock.

[0138] In certain embodiments, the cosmetic composition is for use on the skin. In certain embodiments, the composition is for use on the face, neck, body, and / or around the eye area. In certain embodiments, the composition is an emulsion or gel, preferably an oil-in-water (o / w), cream gel, aqueous-alcoholic gel, or hydrogel composition. In preferred embodiments, the composition has a viscosity of 100,000 to 200,000 mPa·s, preferably 1,000 to 100,000 mPa·s, even more preferably 2,000 to 50,000 mPa·s, and very preferably 5,000 to 30,000 mPa·s (measured at 25°C, Brookfield RVT, TC spindle, 20 revolutions per minute).

[0139] In certain embodiments, the composition is a body or face care composition, such as a face cream, neck cream, body lotion, body milk, face serum, blemish balm cream, hand cream, foot cream, body butter, lip balm, eye cream, after-sun lotion, makeup remover lotion or body mist, diaper cream or baby lotion. Optionally, the body or face care composition comprises 0.1% to 15% by weight, preferably 0.5% to 10% by weight, and even more preferably 1.0% to 5.0% by weight of at least one emulsifier, co-emulsifier and / or solubilizer. Emulsifiers, co-emulsifiers and / or solubilizers are listed above. In certain embodiments, the emulsifier, co-emulsifier and / or solubilizer is selected from the group consisting of glyceryl stearate, cetearyl alcohol, polysorbate 20, stearic acid, cetearyl glucoside, PEG-40 hydrogenated castor oil, cetyl phosphate, steareth-2, ceteth-10 phosphate, trilaureth-4 phosphate, polyglyceryl-2 sesquiisostearate, cetyl PEG / PPG-10 / 1 dimethicone, and combinations thereof.

[0140] Optionally, the body or face care composition comprises 0.01% to 40% by weight, preferably 0.05% to 30% by weight, and even more preferably 0.1% to 20% by weight of at least one oily substance. The oily substances are listed above. In certain embodiments, the oily substance is selected from the group consisting of sweet almond oil, argan oil, caprylic / capric triglyceride, dimethicone, squalane, apricot kernel oil, coconut oil, jojoba oil, shea butter, mineral oil, isopropyl isostearate, dicaprylyl carbonate, isohexadecane, and combinations thereof.

[0141] Optionally, the body or face care composition comprises 0.01% to 20% by weight, preferably 0.05% to 10% by weight, and even more preferably 0.1% to 5.0% by weight of at least one wax. Waxes are listed above. In certain embodiments, the wax is selected from the group consisting of carnauba wax, beeswax, candelilla wax, synthetic wax, polyethylene, paraffin wax, microcrystalline wax, hydrogenated vegetable oil, hydrogenated castor oil, rice bran wax, cetyl dimethicone, and combinations thereof.

[0142] Optionally, the body or face care composition comprises 0.01% to 15% by weight, preferably 0.1% to 10% by weight, and even more preferably 0.3% to 5.0% by weight of at least one viscosity modifier or thickener and / or gelling agent. Viscosity modifiers or thickeners and / or gelling agents are listed above. In certain embodiments, the viscosity modifiers or thickeners and / or gelling agents are selected from the group consisting of carbomer, acrylate copolymer, xanthan gum, hydroxyethyl cellulose, polyamide, and combinations thereof.

[0143] Optionally, the body or face care composition comprises 0.001% to 5.0% by weight, preferably 0.05% to 3.0% by weight, and even more preferably 0.1% to 1.0% by weight of at least one skin conditioning agent. Skin conditioning agents are listed above. In certain embodiments, the skin conditioning agent is selected from the group consisting of urea, glycerin, pyrrolidone carboxylic acid (PCA) and its derivatives, panthenol, petrolatum, and combinations thereof.

[0144] Optionally, the body or face care composition comprises 0.001% to 10% by weight, preferably 0.05% to 5.0% by weight, even more preferably 0.1% to 3.0% by weight, and most preferably 0.05% to 1.0% by weight of at least one antioxidant. Antioxidants are listed above. In certain embodiments, the antioxidant is selected from the group consisting of vitamin A, vitamin A derivatives, vitamin E, vitamin E derivatives, BHT, and combinations thereof.

[0145] Optionally, the body or face care composition comprises 0.001% to 5.0% by weight, preferably 0.01% to 3.0% by weight, and even more preferably 0.1% to 2.0% by weight of at least one biogenic active. Biogenic actives are listed above. In certain embodiments, the biogenic active is selected from the group consisting of aloe vera extract, collagen hydrolysate, bisabolol, vitamin C, vitamin E, allantoin, vitamin B5, tocopheryl acetate, retinyl palmitate, and combinations thereof.

[0146] Optionally, the body or face care composition comprises 0.01% to 4.0% by weight, preferably 0.1% to 3.0% by weight, and even more preferably 0.4% to 1.0% by weight of at least one preservative or preservative-boosting ingredient. Preservatives or preservative-boosting ingredients are listed above. In certain embodiments, the preservative or preservative-boosting ingredient is selected from the group consisting of methylparaben, phenoxyethanol, DMDM ​​hydantoin, ethylhexylglycerin, sodium benzoate, potassium sorbate, levulinic acid, p-anisic acid, sorbitan caprylate, and combinations thereof.

[0147] Optionally, the body or face care composition comprises from 0.01% to 3.0% by weight, preferably from 0.05% to 2.0% by weight, and even more preferably from 0.1% to 1.0% by weight of at least one fragrance or fragrance ingredient or those listed above.

[0148] Optionally, the body or face care composition comprises from 0.01% to 20% by weight, preferably from 0.1% to 10% by weight, even more preferably from 0.5% to 5.0% by weight of at least one further adjuvant, as listed above.

[0149] In a preferred embodiment, the body or face care composition has a pH value of 2.0 to 10.0, preferably 3.0 to 9.0, even more preferably 4.0 to 8.0, and very preferably 5.0 to 7.0.

[0150] In certain embodiments, the composition is a cleansing composition, such as a body wash, face wash, micellar water or gel, body scrub, face peel, facial exfoliator, liquid soap, bath additive, bubble bath, shower cream or milk, shower foam, or face mask. Optionally, the cleansing composition contains 0.5% to 25% by weight, preferably 1.0% to 20% by weight, and even more preferably 2.0% to 15% by weight, of at least one surfactant. Surfactants are listed above. In certain embodiments, the surfactant is selected from the group consisting of sodium laureth sulfate, sodium lauryl sulfate, ammonium lauryl sulfate, sodium lauroyl sarcosinate, sodium methyl cocoyl taurate, cocamidopropyl betaine, sodium cocoyl glutamate, lauryl glucoside, cocoyl methyl glucamide, and combinations thereof.

[0151] Optionally, the cleansing composition comprises 0.01% to 15% by weight, preferably 0.1% to 10% by weight, and even more preferably 0.5% to 5.0% by weight of at least one viscosity modifier or thickener. Viscosity modifiers or thickeners are listed above. In certain embodiments, the viscosity modifier or thickener is selected from the group consisting of carbomer, acrylate copolymer, xanthan gum, laureth-3 or -4, cocamide DEA, coco-glucoside, stearyl alcohol, and combinations thereof.

[0152] Optionally, the cleansing composition comprises 0.01% to 15% by weight, preferably 0.05% to 10% by weight, and even more preferably 0.5% to 5.0% by weight of at least one particulate material. Particulate materials are listed above. In certain embodiments, the particulate material is selected from the group consisting of silica, mica, bentonite, kaolin, talc, polyethylene, clay, and combinations thereof.

[0153] Optionally, the cleansing composition comprises 0.001% to 30% by weight, preferably 0.05% to 20% by weight, and even more preferably 0.1% to 10% by weight of at least one oily substance. The oily substances are listed above. In certain embodiments, the oily substance is selected from the group consisting of sweet almond oil, caprylic / capric triglyceride, dimethicone, mineral oil, squalane, castor oil, isopropyl isostearate, jojoba oil, dicaprylyl carbonate, isohexadecane, C 12 ~C 15 alkyl benzoates, and combinations thereof.

[0154] Optionally, the cleansing composition comprises 0.05% to 15% by weight, preferably 0.1% to 10% by weight, and even more preferably 0.5% to 5.0% by weight of at least one functional acid and / or active ingredient. The functional acids and / or active ingredients are listed above. In certain embodiments, the functional acid and / or active ingredient is selected from the group consisting of alpha- and beta-hydroxy acids, lactic acid, glycolic acid, salicylic acid, citric acid, vitamin C derivatives, protease, and combinations thereof.

[0155] Optionally, the cleansing composition comprises 0.001% to 5.0% by weight, preferably 0.05% to 3.0% by weight, and even more preferably 0.1% to 1.0% by weight of at least one electrolyte. Electrolytes are listed above. In certain embodiments, the electrolyte is selected from the group consisting of sodium chloride, magnesium chloride, sodium citrate, sodium acetate, and combinations thereof.

[0156] Optionally, the cleansing composition comprises 0.01% to 5.0% by weight, preferably 0.1% to 3.0% by weight, and even more preferably 0.4% to 1.0% by weight of at least one preservative or preservative-boosting ingredient. Preservatives or preservative-boosting ingredients are listed above. In certain embodiments, the preservative or preservative-boosting ingredient is selected from the group consisting of sodium benzoate, methylisothiazolinone, benzoic acid, methylparaben, phenoxyethanol, DMDM ​​hydantoin, potassium sorbate, and combinations thereof.

[0157] Optionally, the cleansing composition comprises 0.01% to 20% by weight, preferably 0.1% to 10% by weight, and even more preferably 0.5% to 5.0% by weight of at least one further adjuvant, as listed above.

[0158] In a preferred embodiment, the cleansing composition has a pH value of 2.0 to 10.0, preferably 3.0 to 8.0, even more preferably 4.0 to 7.0.

[0159] In certain embodiments, the composition is a suncare composition, such as a sunspray, sun milk, sun lotion, or sun gel. Body and face care compositions containing sunscreens and / or UV-blocking agents, such as day creams, hand creams, foundations, lip balms, and face serums, can also function as suncare compositions. Optionally, the suncare composition contains 0.1% to 15% by weight, preferably 0.5% to 10% by weight, and even more preferably 1.0% to 5.0% by weight, of at least one emulsifier, co-emulsifier, and / or solubilizer. Emulsifiers, co-emulsifiers, and / or solubilizers are listed above. In certain embodiments, the emulsifier, co-emulsifier and / or solubilizer is selected from the group consisting of glyceryl stearate, cetearyl alcohol, polysorbate 20, stearic acid, cetearyl glucoside, PEG-40 hydrogenated castor oil, cetyl phosphate, steareth-2, ceteth-10 phosphate, trilaureth-4 phosphate, polyglyceryl-2 sesquiisostearate, cetyl PEG / PPG-10 / 1 dimethicone, and combinations thereof.

[0160] Optionally, the sun care composition comprises 0.001% to 50% by weight, preferably 0.05% to 40% by weight, and even more preferably 0.1% to 30% by weight of at least one oily substance. The oily substances are listed above. In certain embodiments, the oily substance is selected from the group consisting of sweet almond oil, caprylic / capric triglyceride, dimethicone, mineral oil, squalane, castor oil, isopropyl isostearate, jojoba oil, dicaprylyl carbonate, cyclopentasiloxane, isohexadecane, C 12 ~C 15 alkyl benzoates, and combinations thereof.

[0161] Optionally, the suncare composition comprises 0.001% to 30% by weight, preferably 0.05% to 20% by weight, even more preferably 0.1% to 10% by weight, and most preferably 0.05% to 5.0% by weight of at least one sunscreen and / or UV blocker. The sunscreen and / or UV blocker are listed above. In certain embodiments, the sunscreen and UV blocker are selected from the group consisting of 2-ethylhexyl 4-methoxycinnamate, methyl methoxycinnamate, 2-ethylhexyl salicylate, 2-ethylhexyl-2-cyano-3,3-diphenyl-2-propenoate, 2-hydroxy-4-methoxybenzophenone-5-sulfonic acid, polyethoxylated p-aminobenzoate, and combinations thereof.

[0162] Optionally, the sun care composition comprises 0.1% to 10% by weight, preferably 0.5% to 7.5% by weight, and even more preferably 1.0% to 5.0% by weight of at least one film-forming agent. Film-forming agents are listed above. In certain embodiments, the film-forming agent is selected from the group consisting of VP / eicosene copolymer, acrylates / octylacrylamide copolymer, VP / VA copolymer, styrene / acrylate copolymer, acrylate copolymer, butyl ester of PVM / MA copolymer, hydroxyethyl cellulose, polypropylsilsesquioxane, polyurethane-64, acrylates / polytrimethylsiloxymethacrylate copolymer, and combinations thereof.

[0163] Optionally, the sun care composition comprises 0.01% to 5.0% by weight, preferably 0.1% to 3.0% by weight, and even more preferably 0.4% to 1.0% by weight of at least one preservative or preservative-boosting ingredient. Preservatives or preservative-boosting ingredients are listed above. In certain embodiments, the preservative or preservative-boosting ingredient is selected from the group consisting of methylparaben, phenoxyethanol, DMDM ​​hydantoin, ethylhexylglycerin, sodium benzoate, potassium sorbate, sorbitan caprylate, and combinations thereof.

[0164] Optionally, the suncare composition comprises 0.01% to 20% by weight, preferably 0.1% to 10% by weight, even more preferably 0.5% to 5.0% by weight of at least one further adjuvant. The adjuvants are listed above. In a preferred embodiment, the suncare composition has a pH value of 3.0 to 9.0, preferably 4.0 to 8.0, even more preferably 5.0 to 7.0.

[0165] In certain embodiments, the composition is a face toner. Optionally, the face toner composition comprises 0.001% to 5.0% by weight, preferably 0.05% to 3.0% by weight, and even more preferably 0.1% to 1.0% by weight of at least one skin conditioning agent. Skin conditioning agents are listed above. In certain embodiments, the skin conditioning agent is selected from the group consisting of glycerin, urea, hydroxyethyl urea, allantoin, bisabolol, panthenol, and combinations thereof.

[0166] Optionally, the face toner composition comprises 0.01% to 15% by weight, preferably 0.1% to 10% by weight, and even more preferably 0.5% to 5.0% by weight of at least one viscosity modifier or thickener. Viscosity modifiers or thickeners are listed above. In certain embodiments, the viscosity modifier or thickener is selected from the group consisting of carbomer, acrylate copolymer, xanthan gum, carrageenan, and combinations thereof.

[0167] Optionally, the face toner composition comprises 0.01% to 5.0% by weight, preferably 0.1% to 3.0% by weight, and even more preferably 0.4% to 1.0% by weight of at least one preservative or preservative-boosting component. Preservatives or preservative-boosting components are listed above. In certain embodiments, the preservative or preservative-boosting component is selected from the group consisting of methylparaben, phenoxyethanol, methylisothiazolinone, ethylhexylglycerin, and combinations thereof.

[0168] Optionally, the face toner composition comprises 0.01% to 20% by weight, preferably 0.1% to 10.0% by weight, and even more preferably 0.5% to 5.0% by weight of at least one additional auxiliary agent, which are listed above.

[0169] In a preferred embodiment, the face toner composition has a pH value of 3.0 to 9.0, preferably 4.0 to 8.0, and even more preferably 5.0 to 7.0.

[0170] In certain embodiments, the composition is a bar soap or synthetic detergent composition. Optionally, the bar soap or synthetic detergent composition comprises 1.0% to 50% by weight, preferably 2.0% to 30% by weight, and even more preferably 5.0% to 20% by weight of at least one surfactant. The surfactants are listed above. In certain embodiments, the surfactant is selected from the group consisting of disodium lauryl sulfosuccinate, sodium palm kernelate, sodium palmate, sodium coconutate, sodium tallowate, palm kernelate, sodium cocoyl isethionate, sodium isethionate, sodium lauryl sulfate, cocamidopropyl betaine, and combinations thereof.

[0171] Optionally, the bar soap or synthetic detergent composition comprises 0.01% to 20% by weight, preferably 0.05% to 15% by weight, and even more preferably 0.5% to 10% by weight of at least one particulate material. Particulate materials are listed above. In certain embodiments, the particulate material is selected from the group consisting of silica, calcium carbonate, sodium bicarbonate, titanium dioxide, polyethylene, and combinations thereof.

[0172] Optionally, the bar soap or synthetic detergent composition comprises 0.001% to 5.0% by weight, preferably 0.05% to 3.0% by weight, and even more preferably 0.1% to 1.0% by weight of at least one electrolyte. Electrolytes are listed above. In certain embodiments, the electrolyte is selected from the group consisting of sodium chloride, magnesium chloride, sodium citrate, sodium acetate, and combinations thereof.

[0173] Optionally, the bar soap or synthetic detergent composition comprises from 0.01% to 20% by weight, preferably from 0.1% to 10% by weight, and even more preferably from 0.5% to 5.0% by weight of at least one further adjuvant, as listed above.

[0174] In a preferred embodiment, the bar soap or synthetic detergent composition has a pH value of from 3.0 to 13.0, preferably from 4.0 to 12.0, even more preferably from 5.0 to 10.0.

[0175] In certain embodiments, the composition is suitable for wet wipes. Optionally, the composition suitable for wet wipes comprises 0.1% to 10% by weight, preferably 0.3% to 5.0% by weight, and even more preferably 0.5% to 3.0% by weight of at least one emulsifier, co-emulsifier, and / or solubilizer. The emulsifiers, co-emulsifiers, and / or solubilizers are listed above. In certain embodiments, the emulsifier, co-emulsifier, and / or solubilizer is selected from the group consisting of glyceryl stearate, cetearyl alcohol, polysorbate 20, stearic acid, cetearyl glucoside, PEG-40 hydrogenated castor oil, and combinations thereof.

[0176] Optionally, the composition suitable for wet wipes comprises 0.001% to 30% by weight, preferably 0.05% to 20% by weight, and even more preferably 0.1% to 10% by weight of at least one oily substance. The oily substances are listed above. In certain embodiments, the oily substance is selected from the group consisting of caprylic / capric triglyceride, dimethicone, mineral oil, squalane, castor oil, isopropyl isostearate, jojoba oil, isohexadecane, C 12 ~C 15 alkyl benzoates, and combinations thereof.

[0177] Optionally, the composition suitable for wet wipes comprises 0.01% to 5.0% by weight, preferably 0.1% to 3.0% by weight, and even more preferably 0.4% to 1.0% by weight of at least one preservative or preservative-boosting ingredient. Preservatives or preservative-boosting ingredients are listed above. In certain embodiments, the preservative or preservative-boosting ingredient is selected from the group consisting of methylparaben, phenoxyethanol, sodium benzoate, potassium sorbate, benzoic acid, ethylhexylglycerin, sorbitan caprylate, and combinations thereof.

[0178] Optionally, the composition suitable for wet wipes comprises 0.01% to 20% by weight, preferably 0.1% to 10% by weight, even more preferably 0.5% to 5.0% by weight of at least one further auxiliary agent, as listed above.

[0179] In a preferred embodiment, the composition suitable for wet wipes has a pH value of 2.0 to 10, preferably 3.0 to 9.0, even more preferably 4.0 to 8.0.

[0180] In certain embodiments, the composition is a deodorant and / or antiperspirant composition. In certain embodiments, the composition is in the form of a cream, roll-on, solid, aerosol, or gel. Optionally, the deodorant and / or antiperspirant composition comprises 0.001% to 10% by weight, or 0.01% to 9.0% by weight, or 0.05% to 8.0% by weight, or 0.1% to 5.0% by weight of at least one antiperspirant and / or deodorant. Antiperspirants and deodorants are listed above. In certain embodiments, the antiperspirant and / or deodorant is selected from the group consisting of aluminum chlorohydrate, allantoin, bisabolol, aluminum chloride, magnesium zirconium complex, aluminum zirconium chloride hydroxide, and combinations thereof.

[0181] Optionally, the deodorant and / or antiperspirant composition comprises 0.01% to 3.0% by weight, preferably 0.05% to 2.0% by weight, and even more preferably 0.1% to 1.0% by weight of at least one fragrance or fragrance ingredient. The fragrance or fragrance ingredients are listed above. In certain embodiments, the fragrance or fragrance ingredient is selected from the group consisting of linalool, limonene, geraniol, coumarin, butylphenyl methylpropional, α-isomethyl ionone, citral, hexyl cinnamal, and combinations thereof.

[0182] Optionally, the deodorant and / or antiperspirant composition comprises 0.5% to 60% by weight, preferably 1.0% to 50% by weight, and even more preferably 2.0% to 40% by weight of at least one propellant. Propellant is listed above. In certain embodiments, the propellant is selected from the group consisting of nitrogen, carbon dioxide, pentane, n-butane, isobutane, propane, and combinations thereof.

[0183] Optionally, the deodorant and / or antiperspirant composition comprises 0.01% to 20% by weight, preferably 0.1% to 10% by weight, and even more preferably 0.5% to 5.0% by weight of at least one further adjuvant, as listed above.

[0184] In a preferred embodiment, the deodorant and / or antiperspirant composition has a pH value of 2.0 to 8.0, preferably 3.0 to 7.0, even more preferably 4.0 to 6.0.

[0185] In certain embodiments, the composition is a shaving composition. Optionally, the shaving composition comprises 0.1% to 10% by weight, preferably 0.3% to 5.0% by weight, and even more preferably 0.5% to 3.0% by weight of at least one emulsifier, co-emulsifier, and / or solubilizer. The emulsifiers, co-emulsifiers, and / or solubilizers are listed above. In certain embodiments, the emulsifier, co-emulsifier, and / or solubilizer is selected from the group consisting of cetearyl alcohol, polysorbate 20, palmitic acid, laureth-23, stearic acid, cetearyl glucoside, PEG-40 hydrogenated castor oil, and combinations thereof.

[0186] Optionally, the shaving composition comprises 0.001% to 5.0%, preferably 0.05% to 3.0%, and even more preferably 0.1% to 1.0% by weight of at least one skin conditioning agent. Skin conditioning agents are listed above. In certain embodiments, the skin conditioning agent is selected from the group consisting of glycerin, urea, sorbitol, aloe vera leaf juice, and combinations thereof.

[0187] Optionally, the shaving composition comprises 0.5% to 60%, preferably 1.0% to 50%, and even more preferably 2.0% to 40% by weight of at least one propellant. Propellant is listed above. In certain embodiments, the propellant is selected from the group consisting of nitrogen, carbon dioxide, pentane, n-butane, isobutane, propane, and combinations thereof.

[0188] Optionally, the shaving composition comprises 0.1% to 20%, preferably 0.3% to 10%, and even more preferably 0.5% to 5.0% by weight of at least one surfactant. Surfactants are listed above. In certain embodiments, the surfactant is selected from the group consisting of sodium laureth sulfate, sodium lauryl sulfate, ammonium lauryl sulfate, sodium lauroyl sarcosinate, cocamidopropyl betaine, and combinations thereof.

[0189] Optionally, the shaving composition comprises from 0.01% to 20%, preferably from 0.1% to 10%, and even more preferably from 0.5% to 5.0% by weight of at least one additional adjuvant, as listed above.

[0190] In certain embodiments, the cosmetic, dermatological, or pharmaceutical composition is for use on hair and / or scalp. In certain embodiments, the composition is an emulsion or gel, preferably an oil-in-water (o / w), cream gel, aqueous-alcoholic gel, or hydrogel composition. In preferred embodiments, the hair care composition has a viscosity (25°C, Brookfield RVT, TC spindle, 20 revolutions per minute) of 100,000 to 150,000 mPa·s, preferably 1,000 to 100,000 mPa·s, more preferably 2,000 to 50,000 mPa·s, and very preferably 5,000 to 30,000 mPa·s.

[0191] In certain embodiments, the composition is a shampoo composition. Optionally, the shampoo composition comprises 0.5% to 30% by weight, preferably 1.0% to 15% by weight, and even more preferably 2.0% to 10% by weight of at least one surfactant. Surfactants are listed above. In certain embodiments, the surfactant is selected from the group consisting of sodium laureth sulfate, sodium lauryl sulfate, ammonium lauryl sulfate, sodium lauroyl sarcosinate, sodium methyl cocoyl taurate, cocamidopropyl betaine, sodium cocoyl glutamate, lauryl glucoside, cocoyl methyl glucamide, and combinations thereof.

[0192] Optionally, the shampoo composition comprises 0.1% to 10%, preferably 0.5% to 7.5%, and even more preferably 1.0% to 5.0% by weight of at least one cationic polymer. Cationic polymers are listed above. In certain embodiments, the cationic polymer is selected from the group consisting of polyquaternium-10, guar hydroxypropyltrimonium chloride, polyquaternium-7, polyquaternium-6, and combinations thereof.

[0193] Optionally, the shampoo composition comprises 0.1% to 15%, preferably 0.5% to 10%, and even more preferably 1.0% to 5.0% by weight of at least one pearlescent agent. Pearlescent agents are listed above. In certain embodiments, the cationic polymer is selected from the group consisting of ethylene glycol distearate and / or polyethylene glycol distearate having an average of 3 glycol units, and combinations thereof.

[0194] Optionally, the shampoo composition comprises 0.001% to 5.0% by weight, preferably 0.05% to 3.0% by weight, and even more preferably 0.1% to 1.0% by weight of at least one electrolyte. Electrolytes are listed above. In certain embodiments, the electrolyte is selected from the group consisting of sodium chloride, magnesium chloride, sodium citrate, sodium acetate, and combinations thereof.

[0195] Optionally, the shampoo composition comprises 0.01% to 15% by weight, preferably 0.1% to 10% by weight, and even more preferably 0.5% to 5.0% by weight of at least one viscosity modifier or thickener. Viscosity modifiers or thickeners are listed above. In certain embodiments, the viscosity modifier or thickener is selected from the group consisting of carbomer, acrylate copolymer, xanthan gum, laureth-3 or 4, cocamide DEA, coco-glucoside, stearyl alcohol, and combinations thereof.

[0196] Optionally, the shampoo composition comprises from 0.01% to 5.0%, preferably from 0.1% to 3.0%, and even more preferably from 0.4% to 1.0% by weight of at least one preservative or preservative boosting ingredient, as listed above.

[0197] Optionally, the shampoo composition comprises from 0.01% to 20%, preferably from 0.1% to 10%, and even more preferably from 0.5% to 5.0% by weight of at least one further adjuvant, as listed above.

[0198] In certain embodiments, the composition is a hair conditioning and / or hair and / or scalp treatment composition, such as a leave-in and rinse-off conditioner, a mask, a lotion, a combing cream, a detangling cream, an anti-frizz liquid, a hair serum, a scalp serum, a color-protecting cream.

[0199] Optionally, the hair conditioning and / or hair and / or scalp treating composition comprises 0.1% to 15% by weight, preferably 0.5% to 10% by weight, and even more preferably 1.0% to 5.0% by weight of at least one emulsifier, co-emulsifier, and / or solubilizer. The emulsifiers, co-emulsifiers, and / or solubilizers are listed above. In certain embodiments, the emulsifier, co-emulsifier, and / or solubilizer is selected from the group consisting of cetearyl alcohol, cetrimonium chloride, behentrimonium chloride, steartrimonium chloride, cetyl alcohol, stearyl alcohol, stearic acid, isostearamidopropyl dimethylamine, and combinations thereof.

[0200] Optionally, the hair conditioning and / or hair and / or scalp treating composition comprises 0.01% to 20% by weight, preferably 0.05% to 10% by weight, and even more preferably 0.1% to 5.0% by weight of at least one oily substance. Oily substances are listed above. In certain embodiments, the oily substance is selected from the group consisting of dimethicone, squalane, amodimethicone, argan oil, jojoba oil, cyclopentasiloxane, mineral oil, castor oil, shea butter, and combinations thereof.

[0201] Optionally, the hair conditioning and / or hair and / or scalp treating composition comprises 0.1% to 10%, preferably 0.5% to 7.5%, and even more preferably 1.0% to 5.0% by weight of at least one cationic polymer. Cationic polymers are listed above. In certain embodiments, the cationic polymer is selected from the group consisting of polyquaternium-10, guar hydroxypropyltrimonium chloride, polyquaternium-7, polyquaternium-6, and combinations thereof.

[0202] Optionally, the hair conditioning and / or hair and / or scalp treatment composition comprises 0.001% to 5.0% by weight, preferably 0.01% to 3.0% by weight, and even more preferably 0.1% to 2.0% by weight of at least one biogenic active. Biogenic actives are listed above. In certain embodiments, the biogenic active is selected from the group consisting of aloe collagen hydrolysate, bisabolol, allantoin, hydrolyzed wheat protein, hydrolyzed silk, hydrolyzed keratin, amino acids and derivatives thereof, glycoproteins, and combinations thereof.

[0203] Optionally, the hair conditioning and / or hair and / or scalp treating composition comprises 0.01% to 5.0% by weight, preferably 0.1% to 3.0% by weight, and even more preferably 0.4% to 1.0% by weight of at least one preservative or preservative-boosting ingredient. Preservatives or preservative-boosting ingredients are listed above. In certain embodiments, the preservative or preservative-boosting ingredient is selected from the group consisting of sodium benzoate, methylparaben, phenoxyethanol, methylisothiazolinone, DMDM ​​hydantoin, methylchloroisothiazolinone, zinc pyrithione, and combinations thereof.

[0204] Optionally, the hair conditioning and / or hair and / or scalp treating composition comprises from 0.01% to 20% by weight, preferably from 0.1% to 10% by weight, even more preferably from 0.5% to 5.0% by weight of at least one further adjuvant, as listed above.

[0205] In certain embodiments, the composition is a hair styling composition such as a mousse, gel, spray, or wax.

[0206] Optionally, the hair styling composition comprises 0.1% to 10% by weight, preferably 0.5% to 7.5% by weight, and even more preferably 1.0% to 5.0% by weight of at least one film-forming agent. Film-forming agents are listed above. In certain embodiments, the film-forming agent is selected from the group consisting of PVP, VP / VA copolymer, styrene / acrylate copolymer, acrylate copolymer, butyl ester of PVM / MA copolymer, hydroxyethyl cellulose, chitosan, polyquaternium-10, polypropylsilsesquioxane, polyurethane-64, and combinations thereof.

[0207] Optionally, the hair styling composition comprises 0.1% to 10%, preferably 0.5% to 7.5%, and even more preferably 1.0% to 5.0% by weight of at least one cationic polymer. Cationic polymers are listed above. In certain embodiments, the cationic polymer is selected from the group consisting of polyquaternium-10, guar hydroxypropyltrimonium chloride, polyquaternium-7, polyquaternium-6, and combinations thereof.

[0208] Optionally, the hair styling composition comprises 0.5% to 60%, preferably 1.0% to 50%, and even more preferably 2.0% to 40% by weight of at least one propellant. Propellant is listed above. In certain embodiments, the propellant is selected from the group consisting of nitrogen, carbon dioxide, pentane, n-butane, isobutane, propane, and combinations thereof.

[0209] Optionally, the hair styling composition comprises 0.01% to 5.0% by weight, preferably 0.1% to 3.0% by weight, and even more preferably 0.4% to 1.0% by weight of at least one preservative or preservative-boosting ingredient. Preservatives or preservative-boosting ingredients are listed above. In certain embodiments, the preservative or preservative-boosting ingredient is selected from the group consisting of sodium benzoate, methylparaben, phenoxyethanol, methylisothiazolinone, DMDM ​​hydantoin, methylchloroisothiazolinone, zinc pyrithione, and combinations thereof.

[0210] Optionally, the hair styling composition comprises from 0.01% to 20% by weight, preferably from 0.1% to 10.0% by weight, and even more preferably from 0.5% to 5.0% by weight of at least one further adjuvant, as listed above.

[0211] In certain embodiments, the composition is a mouthwash composition. Optionally, the mouthwash composition comprises 0.001% to 3.0% by weight, preferably 0.01% to 2.0% by weight, and even more preferably 0.05% to 1.0% by weight of at least one flavoring agent. Flavoring agents are listed above. In certain embodiments, the flavoring agent is selected from the group consisting of stevioside, xylitol, sodium saccharin, sorbitol, methyl salicylate, menthol, eucalyptol, thymol, and combinations thereof.

[0212] Optionally, the mouthwash composition comprises 0.1% to 6.0% by weight, preferably 0.2% to 4.0% by weight, and even more preferably 0.3% to 2.0% by weight of at least one solubilizing agent. Solubilizing agents are listed above. In certain embodiments, the solubilizing agent is selected from the group consisting of PEG-40 hydrogenated castor oil, polysorbate 20, poloxamer 407, and combinations thereof.

[0213] Optionally, the mouthwash composition comprises 0.001% to 5.0% by weight, preferably 0.05% to 3.0% by weight, and even more preferably 0.1% to 1.0% by weight of at least one electrolyte. Electrolytes are listed above. In certain embodiments, the electrolyte is selected from the group consisting of sodium fluoride, sodium monofluorophosphate, stannous fluoride, and combinations thereof.

[0214] Optionally, the mouthwash composition comprises 0.01% to 5.0% by weight, preferably 0.1% to 3.0% by weight, and even more preferably 0.4% to 1.0% by weight of at least one preservative or preservative-boosting ingredient. Preservatives or preservative-boosting ingredients are listed above. In certain embodiments, the preservative or preservative-boosting ingredient is selected from the group consisting of sodium benzoate, benzoic acid, chlorhexidine, and combinations thereof.

[0215] Optionally, the mouthwash composition comprises 0.01% to 20% by weight, preferably 0.1% to 10% by weight, and even more preferably 0.5% to 5.0% by weight of at least one additional adjuvant. The adjuvant is listed above. In a preferred embodiment, the mouthwash composition has a pH value of 2.0 to 10.0, preferably 3.0 to 9.0, and even more preferably 4.0 to 8.0.

[0216] Fourth Aspect A fourth aspect relates to a care method for keratinous materials, comprising: (1) applying a cosmetic composition as described elsewhere herein (e.g., according to the third aspect) or an antimicrobial composition as described elsewhere herein (e.g., according to the first aspect) onto a keratin material; and (2) leaving the composition on the keratinous material for at least 1 hour;

[0217] In certain embodiments, the method comprises applying a cosmetic composition described elsewhere herein onto a keratinous material; and allowing the composition to remain on the keratinous material for at least 1 hour.

[0218] In certain embodiments, the methods described elsewhere herein do not include a rinse-off step (e.g., by refraining from rinsing the treated skin for at least 1 hour, at least 2 hours, at least 4 hours, or at least 6 hours).

[0219] Fifth Aspect A fifth aspect relates to the use of the antimicrobial combination composition of the first aspect in the preservation of a cosmetic composition. [Example]

[0220] example The following examples are intended to illustrate the invention without limiting it thereto.

[0221] Several antimicrobial combination compositions were formulated at a pH of 5.5. These compositions were tested for their ability to inhibit the growth of microbial strains in vitro. The results of these tests are shown in Table 1. "Green" indicates significant inhibition, "Yellow" indicates moderate inhibition, and "Red" indicates little or no inhibition.

[0222] [Table 1]

[0223] Various exemplary embodiments of the present disclosure include, but are not limited to: Embodiment 1 provides an antimicrobial combination composition comprising: (a) one or more glycerol derivatives selected from the group consisting of 3-[(2-ethylhexyl)oxy]-1,2-propanediol, 3-[(n-octyl)oxy]-1,2-propanediol, and 3-[(2-octyl)oxy]-1,2-propanediol; and (b) one or more bicyclic compounds selected from the group consisting of 5,7-dihydroxy-2-(4-hydroxyphenyl)chroman-4-one (naringenin), 2-(3,4-dihydroxyphenyl)-3,5,7-trihydroxychromen-4-one (quercetin), 5,7-dihydroxy-2-(3-hydroxy-4-methoxyphenyl)chroman-4-one (hesperetin), and 5,7-dihydroxy-2-(3,4-dihydroxyphenyl)-chroman-4-one (eriodictyol).

[0224] Embodiment 2 is directed to a method for preparing a glycerol derivative selected from the group consisting of 3-[(n-octyl)oxy]-1,2-propanediol and 3-[(2-octyl)oxy]-1,2-propanediol; or one or more glycerol derivatives are selected from the group consisting of 3-[(n-octyl)oxy]-1,2-propanediol and 3-[(2-octyl)oxy]-1,2-propanediol; or one or more glycerol derivatives are selected from the group consisting of 3-[(n-octyl)oxy]-1,2-propanediol and 3-[(2-octyl)oxy]-1,2-propanediol; or the one or more glycerol derivatives are 3-[(2-octyl)oxy]-1,2-propanediol; or the one or more glycerol derivatives are 3-[(2-ethylhexyl)oxy]-1,2-propanediol; or the glycerol derivative may be selected from compounds of formula (I) provided in International Publication WO 2018 / 125734.

[0225] Embodiment 3 provides the antimicrobial composition of embodiments 1 and 2, wherein the antimicrobial combination composition is a concentrate or a working mixture.

[0226] Embodiment 4 provides an antimicrobial composition according to any one of embodiments 1-3, wherein the glycerol derivative of the present disclosure is provided in a purity of at least 99.99%, or at least 99.90%, or at least 99%, or at least 98%, or at least 94% prior to its incorporation into the antimicrobial combination composition.

[0227] Embodiment 5 provides an antimicrobial composition according to any one of embodiments 1 to 4, wherein the bicyclic compound is selected from the group consisting of naringenin, hesperetin, and hesperetin; said one or more bicyclic compounds are naringenin; or said one or more bicyclic compounds are quercetin; or said one or more bicyclic compounds are hesperetin; or said one or more bicyclic compounds are eriodictyol; or said one or more bicyclic compounds are naringenin and quercetin; or said one or more bicyclic compounds are naringenin and hesperetin; or said one or more bicyclic compounds are naringenin and eriodictyol; or said bicyclic compound may be selected from the compounds of formula (II) provided in International Publication WO 2018 / 125734.

[0228] Embodiment 6 provides a composition according to any one of embodiments 1 to 5, wherein the bicyclic compound of the present disclosure is provided in a purity of at least 99.99%, or at least 99.90%, or at least 99%, or at least 98%, or at least 94%, or at least 92%, or at least 90%, or at least 89%, or at least 87%, or at least 85% prior to its incorporation into the antimicrobial combination composition.

[0229] Embodiment 7 provides an antimicrobial composition according to any one of embodiments 1 to 6, wherein the one or more bicyclic compounds are present in an amount ranging from about 50 ppm to about 50,000 ppm (corresponding to 0.005% to 5% by weight), based on the total weight of the one or more glycerol derivatives; or from about 100 ppm to about 10,000 ppm, or from about 200 ppm to about 5,000 ppm, or from about 500 ppm to about 1,000 ppm, or from about 300 ppm to about 900 ppm, based on the total weight of the one or more glycerol derivatives.

[0230] Embodiment 8 provides an antimicrobial composition according to any one of embodiments 1 to 7, wherein the one or more bicyclic compounds are present in less than 5% by weight, or less than 3% by weight, or less than 1% by weight, or even less than 0.5% by weight, based on the total weight of the one or more glycerol derivatives; or the one or more bicyclic compounds are naringenin (5,7-dihydroxy-2-(4-hydroxyphenyl)chroman-4-one), present in an amount of less than 5% by weight, or less than 3% by weight, or less than 1% by weight, or even less than 0.5% by weight, based on the total weight of the one or more glycerol derivatives.

[0231] Embodiment 9 provides an antimicrobial composition of any one of embodiments 1 to 8, wherein (a) the one or more glycerol derivatives are selected from the group consisting of 3-[(n-octyl)oxy]-1,2-propanediol and 3-[(2-octyl)oxy]-1,2-propanediol; and (b) the one or more bicyclic compounds is naringenin.

[0232] Embodiment 10 provides an antimicrobial composition of any one of embodiments 1 to 8, wherein (a) the one or more glycerol derivatives are selected from the group consisting of 3-[(2-ethylhexyl)oxy]-1,2-propanediol; and (b) the one or more bicyclic compounds is naringenin.

[0233] Embodiment 11 provides an antimicrobial composition of any one of embodiments 1 to 8, wherein (a) the one or more glycerol derivatives is 3-[(n-octyl)oxy]-1,2-propanediol; and (b) the one or more bicyclic compounds is naringenin.

[0234] Embodiment 12 provides an antimicrobial composition of any one of embodiments 1 to 8, wherein (a) the one or more glycerol derivatives is 3-[(2-octyl)oxy]-1,2-propanediol; and (b) the one or more bicyclic compounds is naringenin.

[0235] Embodiment 13 provides the antimicrobial composition of any one of embodiments 1 to 8, wherein (a) the one or more glycerol derivatives are selected from the group consisting of 3-[(n-octyl)oxy]-1,2-propanediol and 3-[(2-octyl)oxy]-1,2-propanediol; and (b) the one or more bicyclic compounds is quercetin.

[0236] Embodiment 14 provides an antimicrobial composition of any one of embodiments 1 to 8, wherein (a) the one or more glycerol derivatives is 3-[(2-ethylhexyl)oxy]-1,2-propanediol; and (b) the one or more bicyclic compounds is quercetin.

[0237] Embodiment 15 provides an antimicrobial composition of any one of embodiments 1 to 8, wherein (a) the one or more glycerol derivatives is 3-[(n-octyl)oxy]-1,2-propanediol; and (b) the one or more bicyclic compounds is quercetin.

[0238] Embodiment 16 provides an antimicrobial composition of any one of embodiments 1 to 8, wherein (a) the one or more glycerol derivatives is 3-[(2-octyl)oxy]-1,2-propanediol; and (b) the one or more bicyclic compounds is quercetin.

[0239] Embodiment 17 provides an antimicrobial composition of any one of embodiments 1 to 8, wherein (a) the one or more glycerol derivatives are selected from the group consisting of 3-[(n-octyl)oxy]-1,2-propanediol and 3-[(2-octyl)oxy]-1,2-propanediol; and (b) the one or more bicyclic compounds is hesperetin.

[0240] Embodiment 18 provides an antimicrobial composition of any one of embodiments 1 to 8, wherein (a) the one or more glycerol derivatives is 3-[(2-ethylhexyl)oxy]-1,2-propanediol; and (b) the one or more bicyclic compounds is hesperetin.

[0241] Embodiment 19 provides an antimicrobial composition of any one of embodiments 1 to 8, wherein (a) the one or more glycerol derivatives is 3-[(n-octyl)oxy]-1,2-propanediol; and (b) the one or more bicyclic compounds is hesperetin.

[0242] Embodiment 20 provides an antimicrobial composition of any one of embodiments 1 to 8, wherein (a) the one or more glycerol derivatives is 3-[(2-octyl)oxy]-1,2-propanediol; and (b) the one or more bicyclic compounds is hesperetin.

[0243] Embodiment 21 provides an antimicrobial composition of any one of embodiments 1 to 8, wherein (a) the one or more glycerol derivatives are selected from the group consisting of 3-[(n-octyl)oxy]-1,2-propanediol and 3-[(2-octyl)oxy]-1,2-propanediol; and (b) the one or more bicyclic compounds is eriodictyol.

[0244] Embodiment 22 provides an antimicrobial composition of any one of embodiments 1 to 8, wherein (a) the one or more glycerol derivatives is 3-[(2-ethylhexyl)oxy]-1,2-propanediol; and (b) the one or more bicyclic compounds is eriodictyol.

[0245] Embodiment 23 provides an antimicrobial composition of any one of embodiments 1 to 8, wherein (a) the one or more glycerol derivatives is 3-[(n-octyl)oxy]-1,2-propanediol; and (b) the one or more bicyclic compounds is eriodictyol.

[0246] Embodiment 24 provides an antimicrobial composition of any one of embodiments 1 to 8, wherein (a) the one or more glycerol derivatives is 3-[(2-octyl)oxy]-1,2-propanediol; and (b) the one or more bicyclic compounds is eriodictyol.

[0247] Embodiment 25 provides the antimicrobial composition of any one of embodiments 1 to 24 in the form of a concentrate (e.g., which can be further used in cosmetic or pharmaceutical formulations).

[0248] Embodiment 26 provides the antimicrobial composition of any one of embodiments 1 to 24 in the form of a use solution.

[0249] Embodiment 27: The antimicrobial composition of embodiment 26, wherein the antimicrobial combination composition is further diluted to a concentration of 10% to 60% by weight to provide a use solution.

[0250] Embodiment 28 provides the antimicrobial composition of embodiment 26 or 27, wherein the antimicrobial combination composition is further diluted with an additive (e.g., a diluent or excipient).

[0251] Embodiment 29 provides the antimicrobial composition of embodiment 28, wherein the additive is water, alcohol(s), polyol(s), or mixtures thereof.

[0252] Embodiment 30 provides an antimicrobial composition of any one of embodiments 1 to 29 that is substantially free or completely free of one or more peroxides (e.g., less than 1000 ppm, or less than 100 ppm, or less than 10 ppm, or even less than 1 ppm of peroxide(s).

[0253] Embodiment 31 provides the antimicrobial composition of any one of embodiments 1 to 30, wherein the composition is part of a deodorant, a skin care product, a sunscreen, a baby product, a cosmetic, an aftershave product, a disinfectant, an antiseptic, a cleansing lotion, an in-shower lotion, and a hair treatment composition (e.g., a leave-in or rinse-out composition).

[0254] Embodiment 32 provides an antimicrobial composition according to any one of embodiments 1 to 31 for use as a medicament.

[0255] Embodiment 33 provides an antimicrobial composition according to any one of embodiments 1 to 31 for use in the (prophylactic) treatment of an infection on the human or animal body.

[0256] Embodiment 34 provides a cosmetic composition comprising the antimicrobial combination composition of any of embodiments 1 to 30; specifically embodiment 34 provides a cosmetic composition comprising: (a) one or more glycerol derivatives selected from the group consisting of 3-[(2-ethylhexyl)oxy]-1,2-propanediol, 3-[(n-octyl)oxy]-1,2-propanediol, and 3-[(2-octyl)oxy]-1,2-propanediol; and (b) one or more bicyclic compounds selected from the group consisting of 5,7-dihydroxy-2-(4-hydroxyphenyl)chroman-4-one (naringenin), 2-(3,4-dihydroxyphenyl)-3,5,7-trihydroxychromen-4-one (quercetin), 5,7-dihydroxy-2-(3-hydroxy-4-methoxyphenyl)chroman-4-one (hesperetin), and 5,7-dihydroxy-2-(3,4-dihydroxyphenyl)-chroman-4-one (eriodictyol).

[0257] Embodiment 35 provides the cosmetic composition of embodiment 34, having a pH value within the range of 2.0 to 7.0, or 3.0 to 7.0, or 4.5 to 7.0, or pH 4 to pH 6.5, or pH 4 to pH 6, or pH 4.5 to pH 6.5, or pH 4.5 to pH 6, or pH 5.3 to pH 5.7, or pH 5 to pH 6, or about pH 5.5.

[0258] Embodiment 36 provides the cosmetic composition of embodiment 34 or 35 for leave-on skin care use.

[0259] Embodiment 37 is a cosmetic composition comprising an antimicrobial combination composition in an amount of up to about 60% by weight, based on the total weight of the cosmetic composition; or from 1% to 60% by weight, or from 10% to 60% by weight, or from 20% to 60% by weight, or from 30% to 60% by weight, or from 40% to 60% by weight, or from 50% to 60% by weight, or from 1% to 40% by weight, or from 10% to 40% by weight, or from 20% to 40% by weight, based on the total weight of the cosmetic composition. 37. The cosmetic composition of any one of embodiments 34 to 36, wherein the antimicrobial combination composition is present in the range of 1 wt. %, or 30 wt. % to 40 wt. %, or 1 wt. % to 30 wt. %, or 10 wt. % to 30 wt. %, or 20 wt. % to 30 wt. %, or 1 wt. % to 20 wt. %, or 10 wt. % to 20 wt. %, or 15 wt. % to 20 wt. %, or 1 wt. % to 15 wt. %, or 1 wt. % to 10 wt. %, or 1 wt. % to 5 wt. % of the antimicrobial combination composition.

[0260] Embodiment 37-a is a cosmetic composition in which the amount of the one or more glycerol derivatives present in the cosmetic composition is in the range of about 0.0005% by weight to about 5% by weight, for example, about 0.001% by weight to about 5% by weight, or about 0.01% by weight to about 5% by weight, or about 0.1% by weight to about 5% by weight, or about 1% by weight to about 5% by weight, or 0.0005% by weight to about 1% by weight, based on the total weight of the cosmetic composition. %, or about 0.001% to about 1% by weight, or about 0.01% to about 1% by weight, or about 0.1% to about 1% by weight, or about 0.5% to about 1% by weight, or 0.0005% to about 0.5% by weight, or about 0.001% to about 0.5% by weight, or about 0.01% to about 0.5% by weight, or about 0.1% to about 0.5% by weight, or about 0.5% to about 0.5 % by weight, or 0.0005% by weight to about 0.1% by weight, or about 0.001% by weight to about 0.1% by weight, or about 0.01% by weight to about 0.1% by weight, about 0.05% by weight to about 5% by weight, or about 0.1% by weight to about 1% by weight, or about 0.1% by weight to about 0.6% by weight, or about 0.1% by weight to about 0.5% by weight, or about 0.1% by weight to about 0.4% by weight, or about 0.2% by weight to about 1% by weight %, or about 0.2 wt % to about 0.6 wt %, or about 0.2 wt % to about 0.5 wt %, or about 0.2 wt % to about 0.4 wt %, or about 0.4 wt % to about 1 wt %, or about 0.4 wt % to about 0.6 wt %, or about 0.4 wt % to about 0.5 wt %, or about 0.3 wt %, or about 0.5%.

[0261] Embodiment 37-b provides a cosmetic composition according to any one of embodiments 34 to 37a, wherein the amount of the one or more bicyclic compounds present in the cosmetic composition is in the range of about 50 ppm to about 50,000 ppm (corresponding to 0.005% by weight to 5% by weight), based on the total weight of the one or more glycerol derivatives present in the cosmetic composition; for example, in the range of about 100 ppm to about 10,000 ppm, or about 200 ppm to about 5,000 ppm, or about 500 ppm to about 1,000 ppm, or about 300 ppm to about 900 ppm, based on the total weight of the one or more glycerol derivatives present in the cosmetic composition.

[0262] Embodiment 37-c provides a cosmetic composition according to any one of embodiments 34-37b, wherein the amount of one or more bicyclic compounds present in the cosmetic composition includes an additional amount of one or more bicyclic compounds (i.e., in addition to the compounds provided in connection with the antimicrobial combination composition).

[0263] Embodiment 38 provides the cosmetic composition of any of embodiments 34 to 37c, further comprising one or more additives selected from surfactants and adjuvants.

[0264] Embodiment 39 provides the cosmetic composition of embodiment 38, wherein the cosmetic composition comprises one or more surfactants.

[0265] Embodiment 40 provides the cosmetic composition of embodiment 38 or 39, wherein the one or more surfactants are selected from the group consisting of anionic surfactants, cationic surfactants, nonionic surfactants, zwitterionic surfactants, and / or amphoteric surfactants (all as described herein).

[0266] Embodiment 41 provides the cosmetic composition of any of embodiments 38 to 40, wherein the one or more surfactants are present in an amount of 0.01 wt % to 70 wt %, 0.1 wt % to 40 wt %, 1 wt % to 30 wt %, or 2 wt % to 20 wt %, based on the total weight of the cosmetic composition.

[0267] Embodiment 42 provides the cosmetic composition of any of embodiments 38 to 41, further comprising a fatty acyl isethionate (e.g., at a level of 1 to 10 wt. %, or 2 to 8 wt. %, or 2.5 to 7.5 wt. %, based on the total weight of the composition), as described elsewhere herein.

[0268] Embodiment 43 provides a cosmetic composition according to any one of embodiments 38 to 42, wherein the one or more surfactants comprise one or more acylglycinate surfactants (such as, for example, a compound of formula (Y)), glutamate surfactants (such as, for example, a compound of formula (Z)), for example, in an amount of 0.01 wt % to 30 wt %, or 1 wt % to 25 wt %, or 5 wt % to 20 wt %, or 12 wt % to 18 wt %, respectively, based on the total weight of the composition.

[0269] Embodiment 44 is a method for preparing a composition comprising one or more surfactants selected from the group consisting of one or more non-ionic surfactants, such as alkyl ethoxylates, alkyl polyglycosides (APGs), ethoxylated fatty alcohols, fatty acids, fatty acid glycerides or alkyl phenols, fatty alcohol ethoxylates (alkyl polyethylene glycols), alkyl phenol polyethylene glycols, alkyl mercaptan polyethylene glycols, fatty amine ethoxylates (alkylamino polyethylene glycols), fatty acid ethoxylates (acyl polyethylene glycols), polypropylene glycol ethoxylates (Pluronics (登録商標) ), fatty acid alkylolamides (fatty acid amide polyethylene glycols), N-alkyl-, N-alkoxypolyhydroxy-fatty acid amides, sucrose esters, sorbitol esters, polyglycol ethers, and sugar-derived nonionic surfactants (e.g., compounds of formula (X)) as described herein.

[0270] Embodiment 45 provides the cosmetic composition of embodiment 44, wherein the cosmetic composition comprises from 1 wt. % to 20 wt. %, more preferably from 2 wt. % to 10 wt. %, and even more preferably from 3 wt. % to 7 wt. % of a nonionic surfactant.

[0271] Embodiment 46 provides a cosmetic composition according to any one of embodiments 38 to 45, wherein the one or more surfactants comprise an amphoteric or zwitterionic surfactant, for example, in an amount ranging from 0.5% to about 8% by weight, preferably from 1% to 4% by weight, of the total composition.

[0272] Embodiment 47 is a method for preparing an amphoteric surfactant, comprising administering to a subject a compound selected from the group consisting of N—(C ) alkyl esters as alkali metal salts and mono-, di-, and trialkylammonium salts. 12 -C 18 )-Alkyl-β-aminopropionates and N-(C 12 -C 18 )-Alkyl-β-iminodipropionates; N-Acylaminoalkyl-N,N-dimethylacetobetaines, preferably N-(C 18 )-Acylaminopropyl-N,N-dimethylacetobetaine, (C 12 -C 18 )-Alkyl-dimethylsulfopropyl betaine, an imidazoline-based amphoteric surfactant (trade name: Miranol (登録商標) , Steinapon (登録商標) ), preferably the sodium salt of 1-(β-carboxymethyloxyethyl)-1-(carboxymethyl)-2-laurylimidazolinium; amine oxides, such as (C 12 -C 18 47. The cosmetic composition of claim 46, wherein the alkyl dimethyl amine oxide is selected from the group consisting of methyl 2-(2-methyl-2-propanol), ...

[0273] Embodiment 48 is a method for preparing a hydroxybenzoate comprising the step of: providing one or more surfactants selected from the group consisting of betaine surfactants, such as cocodimethylcarboxymethyl betaine, lauryldimethylcarboxymethyl betaine, lauryldimethylalphacarboxyethyl betaine, cetyldimethylcarboxymethyl betaine, oleyldimethylgammacarboxypropyl betaine, and laurylbis(2-hydroxypropyl)alphacarboxyethyl betaine, cocodimethylsulfopropyl betaine, stearyldimethylsulfopropyl betaine, lauryldimethylsulfoethyl betaine, laurylbis(2-hydroxyethyl)sulfopropyl betaine, carboxyl derivatives of imidazole, C8-C 18 -Alkyldimethylammonium acetate, C8-~C 18 48. The cosmetic composition according to any one of embodiments 38 to 47, comprising N-alkyldimethylcarbonylmethylammonium salt, coconut fatty acid amidopropyl betaine, N-cocoamidoethyl-N-[2-(carboxymethoxy)ethyl]glycerol (CTFA name: cocoamphocarboxyglycinate), and mixtures thereof.

[0274] Embodiment 49 provides the cosmetic composition of any of embodiments 38 to 48, wherein the composition further comprises a surfactant system (e.g., the surfactant system comprises at least one surfactant selected from the group consisting of lauryl sulfate, laureth sulfate, cocoamidopropyl betaine, sodium cocoyl glutamate, lauroamphoacetate, and mixtures thereof; or sodium laureth sulfate, sodium lauryl sulfate, and optionally cocamidopropyl betaine; or sodium laureth sulfate, potassium cocoyl glutamate, and cocamidopropyl betaine).

[0275] Embodiment 50 provides the cosmetic composition of any one of embodiments 38 to 49, wherein the cosmetic composition comprises one or more adjuvants, such as cosmetically acceptable adjuvants.

[0276] Embodiment 51 is a composition comprising one or more auxiliaries selected from the group consisting of oils, waxes, emulsifiers, co-emulsifiers, solubilizers, cationic polymers, film-forming agents, superfatting agents, refatting agents, foam stabilizers, stabilizers, active biological substances, preservatives, preservation boosting ingredients, and the like. ingredients), antifungals, antidandruff agents, dyes or pigments, particulate matter, opacifiers, abrasives, absorbents, anti-caking agents, bulking agents, pearlescent agents, direct dyes, fragrances or fragrances, carriers, solvents or diluents, propellants, functional acids, active ingredients, skin brighteners, self-tanning agents, exfoliants, enzymes, anti-acne agents, deodorants and antiperspirants, viscosity modifiers, thickeners and gelling agents, pH adjusters, buffers, antioxidants, chelating agents, astringents, sunscreens, sun protection agents, UV filters, skin conditioning agents, emollients, moisturizing agents, occlusive agents, pediculicides, anti-foaming agents, flavoring agents, electrolytes, oxidizing agents, and reducing agents (all as described herein).

[0277] Embodiment 52 provides a cosmetic composition according to embodiment 50 or 51, wherein the one or more auxiliaries comprise an oily substance as described herein in an amount of, for example, 0.001 wt. % to 60 wt. %, preferably 0.05 wt. % to 50 wt. %, and even more preferably 0.1 wt. % to 40 wt. %, based on the total weight of the composition.

[0278] Embodiment 53 provides a cosmetic composition according to any one of embodiments 50 to 52, wherein the one or more auxiliaries comprise a wax as described herein, for example, in an amount of from 0.001 to 30% by weight, preferably from 0.05 to 20% by weight, and even more preferably from 0.1 to 10% by weight, based on the total weight of the composition.

[0279] Embodiment 54 provides a cosmetic composition according to any one of embodiments 50 to 53, wherein the one or more adjuvants are selected from the emulsifiers, co-emulsifiers and solubilizers described elsewhere herein, for example in an amount of from 0.1 wt. % to 20 wt. %, preferably from 0.5 wt. % to 10 wt. %, and even more preferably from 1.0 wt. % to 5.0 wt. %, based on the total weight of the composition.

[0280] Embodiment 55 provides the cosmetic composition according to embodiment 54, wherein the emulsifier, co-emulsifier, and solubilizer are selected from the group consisting of glyceryl stearate, cetearyl alcohol, polysorbate 20, stearic acid, cetearyl glucoside, PEG-40 hydrogenated castor oil, cetyl phosphate, steareth-2, ceteth-10 phosphate, trilaureth-4 phosphate, polyglyceryl-2 sesquiisostearate, cetyl PEG / PPG-10 / 1 dimethicone, cetrimonium chloride, and combinations thereof.

[0281] Embodiment 56 provides a cosmetic composition according to any one of embodiments 50 to 55, wherein the one or more adjuvants are selected from a cationic polymer as described elsewhere herein, a film-forming agent as described elsewhere herein, a superfatting agent and / or a refatting agent as described elsewhere herein, for example, in an amount of from 0.1 wt. % to 10 wt. %, preferably from 0.5 wt. % to 7.5 wt. %, preferably from 1.0 wt. % to 5.0 wt. %, and even more preferably from 0.5 wt. % to 3.0 wt. %, based on the total weight of the composition.

[0282] Embodiment 57 provides a cosmetic composition according to any one of embodiments 50 to 56, wherein the one or more auxiliaries comprise a stabilizer as described elsewhere herein, for example, in an amount of from 0.01 wt. % to 10 wt. %, preferably from 0.5 wt. % to 8.0 wt. %, and even more preferably from 1.0 wt. % to 5.0 wt. %, based on the total weight of the composition.

[0283] Embodiment 58 provides a cosmetic composition according to any one of embodiments 50 to 57, wherein the one or more adjuvants comprise, for example, 0.001 wt. % to 5.0 wt. %, preferably 0.01 wt. % to 3.0 wt. %, and even more preferably 0.1 wt. % to 2.0 wt. % of a biological substance as described elsewhere herein, based on the total weight of the composition.

[0284] Embodiment 59 provides a cosmetic composition according to any one of embodiments 50 to 58, wherein the one or more adjuvants are selected from a preservative, a preservative-boosting component, an antifungal agent, and an antidandruff agent (all as described herein). For example, the composition may comprise 0.01 to 5.0 wt. %, particularly preferably 0.05 to 1.0 wt. %, of a preservative; and / or 0.1 to 1.0 wt. % of an antifungal agent; and / or 0.1 to 4.0%, preferably 0.1 to 3.0%, more preferably 0.3 to 2.0%, of an antidandruff agent.

[0285] Embodiment 60 provides the cosmetic composition of any one of embodiments 38 to 59, wherein the composition further comprises 0.1 wt. % to 5.0 wt. % of an additional antimicrobial agent (such as chlorhexidine).

[0286] Embodiment 61 provides a cosmetic composition according to any one of embodiments 50 to 60, wherein the one or more auxiliaries are selected from dyes or pigments, particulate matter, pearlescent agents, direct dyes, and fragrance or fragrance ingredients. For example, the composition may comprise 0.01% to 20% by weight, preferably 0.05% to 15% by weight, and even more preferably 0.5% to 10% by weight of particulate matter; and / or 0.1% to 15% by weight, preferably 0.5% to 10% by weight, and even more preferably 1.0% to 5.0% by weight of pearlescent agent; and / or 0.1% to 15% by weight, preferably 0.1% to 10% by weight, and even more preferably 0.5% to 8.0% by weight of direct dye; and / or 0.01% to 3.0% by weight, preferably 0.05% to 2.0% by weight, and even more preferably 0.1% to 1.0% by weight of fragrance or fragrance.

[0287] Embodiment 62 provides the cosmetic composition of any one of embodiments 50 to 60, wherein the one or more adjuvants comprise a carrier, a solvent, and / or a diluent.

[0288] Embodiment 63 provides the cosmetic composition of embodiment 62, wherein the solvent comprises water and / or an alcohol as otherwise described herein (e.g., a water-miscible or water-soluble alcohol, such as a C1-C5 alkyl monohydric alcohol or polyhydric alcohol); or the solvent is water.

[0289] Embodiment 64 provides the cosmetic composition of embodiment 62 or 63, wherein the solvent comprises vegetable oil, honey, vegetable sugar composition, and mixtures thereof.

[0290] Embodiment 65 provides the cosmetic composition of any one of embodiments 62 to 64, wherein the cosmetic composition comprises 0.5 wt. % to 90 wt. %, preferably 1.0 wt. % to 80 wt. %, and even more preferably 5.0 wt. % to 70 wt. % of at least one carrier, solvent, and / or diluent.

[0291] Embodiment 66 provides a cosmetic composition according to any one of embodiments 50 to 65, wherein the one or more adjuvants comprise a propellant as described herein, for example, in an amount of from 0.5 wt. % to 60 wt. %, preferably from 1.0 wt. % to 50 wt. %, and even more preferably from 2.0 wt. % to 40 wt. %, based on the total weight of the composition.

[0292] Embodiment 67 provides a cosmetic composition according to any one of embodiments 50 to 66, wherein the one or more auxiliaries comprise a functional acid as described herein and / or an active ingredient as described herein, for example, in an amount of 0.05 wt. % to 15 wt. %, preferably 0.1 wt. % to 10 wt. %, and even more preferably 0.5 wt. % to 5.0 wt. %, based on the total weight of the composition.

[0293] Embodiment 68 provides the cosmetic composition of any one of embodiments 50 to 67, wherein the one or more adjuvants comprise a deodorant as described herein and / or an antiperspirant as described herein. For example, the cosmetic composition comprises 0.001 wt. % to 10 wt. %, or 0.01 wt. % to 9.0 wt. %, or 0.05 wt. % to 8.0 wt. %, or 0.1 wt. % to 5.0 wt. % of a deodorant; and 0.001 wt. % to 10 wt. %, or 0.01 wt. % to 9.0 wt. %, or 0.05 wt. % to 8.0 wt. %, or 0.1 wt. % to 5.0 wt. % of an antiperspirant.

[0294] Embodiment 69 provides a cosmetic composition according to any one of embodiments 50 to 68, wherein the one or more adjuvants comprise a viscosity modifier and / or a thickener and / or a gelling agent (all as described herein), for example in an amount of 0.01 wt. % to 15 wt. %, preferably 0.1 wt. % to 10 wt. %, and even more preferably 0.5 wt. % to 5.0 wt. %, based on the total weight of the composition.

[0295] Embodiment 70 provides a cosmetic composition according to any one of embodiments 50 to 69, wherein the one or more adjuvants comprise an alkalizing agent as described herein and / or a pH adjuster as described herein; for example, in an amount of 0.001 wt. % to 5.0 wt. %, preferably 0.01 wt. % to 3.0 wt. %, and even more preferably 0.1 wt. % to 1.0 wt. %, based on the total weight of the composition.

[0296] Embodiment 71 provides a cosmetic composition according to any one of embodiments 50 to 70, wherein the one or more adjuvants comprise an antioxidant as described elsewhere herein, for example, in an amount of from 0.001 wt. % to 10 wt. %, preferably from 0.05 wt. % to 5.0 wt. %, even more preferably from 0.1 wt. % to 3.0 wt. %, and most preferably from 0.05 wt. % to 1.0 wt. %, based on the total weight of the composition.

[0297] Embodiment 72 provides a cosmetic composition according to any one of embodiments 50 to 71, wherein the one or more adjuvants comprise a chelating agent as described elsewhere herein, for example, in an amount of from 0.01 wt. % to 2.0 wt. %, preferably from 0.05 wt. % to 1.5 wt. %, even more preferably from 0.1 wt. % to 1.0 wt. %, and most preferably from 0.05 wt. % to 1.0 wt. %, based on the total weight of the composition.

[0298] Embodiment 73 provides a cosmetic composition according to any one of embodiments 50 to 72, wherein the one or more adjuvants comprise an astringent as described elsewhere herein, for example, in an amount of from 0.001 wt. % to 10 wt. %, or from 0.01 wt. % to 9.0 wt. %, or from 0.05 wt. % to 8.0 wt. %, or from 0.1 wt. % to 5.0 wt. %, based on the total weight of the composition.

[0299] Embodiment 74 provides a cosmetic composition according to any one of embodiments 50 to 73, wherein the one or more auxiliaries comprise a sunscreen and / or UV blocker as described elsewhere herein, for example, in an amount of from 0.001 wt. % to 30 wt. %, preferably from 0.05 wt. % to 20 wt. %, even more preferably from 0.1 wt. % to 10 wt. %, and most preferably from 0.05 wt. % to 5.0 wt. %, based on the total weight of the composition.

[0300] Embodiment 75 provides a cosmetic composition according to any one of embodiments 50 to 74, wherein the one or more adjuvants comprise a skin conditioning agent as described elsewhere herein, for example, in an amount of from 0.001 wt. % to 5.0 wt. %, preferably from 0.05 wt. % to 3.0 wt. %, and even more preferably from 0.1 wt. % to 1.0 wt. %, based on the total weight of the composition.

[0301] Embodiment 76 provides the cosmetic composition of any one of embodiments 50 to 75, wherein the one or more adjuvants comprise a defoaming agent as described elsewhere herein, for example, in an amount of from 0.01 wt. % to 5.0 wt. %, preferably from 0.1 wt. % to 3.0 wt. %, and even more preferably from 0.5 wt. % to 2.0 wt. %, based on the total weight of the composition.

[0302] Embodiment 77 provides a cosmetic composition according to any one of embodiments 50 to 76, wherein the one or more adjuvants comprise a flavoring agent as described elsewhere herein and / or an electrolyte as described elsewhere herein, for example, in an amount of from 0.001 wt % to 5.0 wt %, or from 0.001 wt % to 3.0 wt %, or from 0.05 wt % to 3.0 wt %, or from 0.01 wt % to 2.0 wt %, or from 0.1 wt % to 1.0 wt %, or from 0.05 wt % to 1.0 wt %, based on the total weight of the composition.

[0303] Embodiment 78 provides a cosmetic composition according to any one of embodiments 50 to 77, wherein the one or more adjuvants comprise an oxidizing agent as described elsewhere herein and / or a reducing agent as described elsewhere herein; for example, in an amount of from 0.001 wt. % to 10 wt. %, preferably from 0.05 wt. % to 7.0 wt. %, and even more preferably from 0.1 wt. % to 5.0 wt. %, based on the total weight of the composition.

[0304] Embodiment 79 provides the cosmetic composition of any one of embodiments 34 to 78, wherein the composition has a viscosity of 0 cPs to 20,000 cPs; or 0.1 cPs to 10,000 cPs, or 1 cPs to 5,000 cPs, or 5 cPs to 3,500 cPs; or 0 cPs to 1,000 cPs.

[0305] Embodiment 80 provides the cosmetic composition of any one of embodiments 34 to 79, wherein the composition further comprises a viscosity modifier (e.g., a thickening polymer).

[0306] Embodiment 81 provides the cosmetic composition of any one of embodiments 34 to 79, wherein the composition is in liquid form.

[0307] Embodiment 82 provides a cosmetic composition according to any one of embodiments 34 to 79, wherein the composition is in a solid form; for example, in a powder form or a granular form.

[0308] Embodiment 83 is the cosmetic composition of any one of embodiments 34 to 82, which is a shampoo, a conditioner (e.g., leave-in or rinse-out), a body wash, a facial cleanser, a face mask, a bubble bath, an intimate wash, wash), bath oil, cleansing emulsion, micellar water, makeup remover, cleansing wipes, hair mask, fragrance, liquid soap, shaving soap, shaving foam, cleansing foam, day cream, anti-aging cream, body milk, body lotion, in-shower body lotion (i.e. no-rinse body lotion), body mousse, face serum, eye cream, sunscreen lotion, sun cream, facial cream, aftershave lotion, pre-shave cream, hair removal cream, skin whitening gel, self-tanning cream, anti-acne gel, mascara, foundation, primer, concealer, blusher, bronzer, blemish balm (bb) cream, eyeliner, night cream, eyebrow gel, highlighter, lip stain, hand sanitizer, hair oil, nail polish The present invention provides a composition selected from the group consisting of a remover, a conditioner, a hair styling gel, a hair styling cream, an anti-frizz serum, a scalp treatment, a hair colorant, a hair removal fluid, a deodorant, an antiperspirant, a baby cream, an insect repellent, a hand cream, a sunscreen gel, a foot cream, an exfoliator, a body scrub, a cellulite treatment, a bar soap, a cuticle cream, a lip balm, a hair treatment, an eye shadow, a bath additive, a body mist, an eau de toilette, a mouthwash, a toothpaste, a lubricating gel, a moisturizer, a serum, a toner, an aquasorbet, a cream gel, a styling mousse, a dry shampoo, a lipstick, a lip gloss, an aqueous-alcoholic gel, a body oil, a shower milk, an illuminator, a lip crayon, a hairspray, a combing cream, and a sunblock.

[0309] Embodiment 84 provides a cosmetic composition according to any one of embodiments 34 to 83, for use on the skin, for example for use on the face, neck, body and / or around the eye area; for example, the composition is an emulsion or gel, preferably an oil-in-water (o / w), cream gel, aqueous-alcoholic gel or hydrogel composition.

[0310] Embodiment 85 provides the cosmetic composition of any one of embodiments 34 to 83, wherein the composition is a body or face care composition, such as a face cream, neck cream, body lotion, body milk, face serum, blemish balm cream, hand cream, foot cream, body butter, lip balm, eye cream, after-sun lotion, makeup remover lotion or body mist, diaper cream or baby lotion; for example, optionally in an amount of from 0.1% to 15% by weight, preferably from 0.5% to 10% by weight. % to 10% by weight, and even more preferably 1.0% to 5.0% by weight, of at least one emulsifier, co-emulsifier and / or solubilizer; and / or optionally comprising 0.01% to 40% by weight, preferably 0.05% to 30% by weight, and even more preferably 0.1% to 20% by weight of at least one oily substance; and / or optionally comprising 0.01% to 20% by weight, preferably 0.05% to 10% by weight, and even more preferably 0.1% to 5.0% by weight of at least one wax; and / or optionally comprising 0.0 1% to 15% by weight, preferably 0.1% to 10% by weight, even more preferably 0.3% to 5.0% by weight of at least one viscosity adjusting or thickening agent and / or gelling agent; and / or optionally 0.001% to 5.0% by weight, preferably 0.05% to 3.0% by weight, even more preferably 0.1% to 1.0% by weight of at least one skin conditioning agent; and / or optionally 0.001% to 10% by weight, preferably 0.05% to 5.0% by weight, even more preferably 0.1% to 3. 0.0% by weight, most preferably 0.05% to 1.0% by weight of at least one antioxidant; and / or 0.001% to 5.0% by weight, preferably 0.01% to 3.0% by weight, even more preferably 0.1% to 2.0% by weight of at least one biogenic active substance; and / or optionally 0.01% to 4.0% by weight, preferably 0.1% to 3.0% by weight, even more preferably 0.4% to 1.0% by weight of at least one preservative or preservative-enhancing ingredient; and / or optionally 0.01% to 3.0% by weight.0% by weight, preferably 0.05% to 2.0% by weight, even more preferably 0.1% to 1.0% by weight of at least one fragrance or aroma ingredient; and / or optionally 0.01% to 20% by weight, preferably 0.1% to 10% by weight, even more preferably 0.5% to 5.0% by weight of at least one further auxiliary agent.

[0311] Embodiment 86 provides the cosmetic composition according to embodiment 85, wherein the composition has a pH value of 2.0 to 10.0, preferably 3.0 to 9.0, even more preferably 4.0 to 8.0, and very preferably 5.0 to 7.0.

[0312] Embodiment 87 provides the cosmetic composition of any one of embodiments 34 to 83, wherein the composition is a body or face care composition, such as a body wash, face wash, micellar water or gel, body scrub, face peel, facial exfoliator, liquid soap, bath additive, bubble bath, shower cream or milk, shower foam, and face mask; and, for example, optionally containing 0.5% to 25% by weight, preferably 1.0% by weight, of a citric acid or citric acid. % to 20% by weight, even more preferably 2.0% to 15% by weight, of at least one surfactant; and / or optionally comprising 0.01% to 15% by weight, preferably 0.1% to 10% by weight, even more preferably 0.5% to 5.0% by weight, of at least one viscosity modifier or thickener; and / or optionally comprising 0.01% to 15% by weight, preferably 0.05% to 10% by weight, even more preferably 0.5% to 5.0% by weight, of at least one particulate material. and / or optionally containing 0.001% to 30% by weight, preferably 0.05% to 20% by weight, even more preferably 0.1% to 10% by weight of at least one oily substance; and / or optionally containing 0.05% to 15% by weight, preferably 0.1% to 10% by weight, even more preferably 0.5% to 5.0% by weight of at least one functional acid and / or active ingredient; and / or optionally containing 0.001% to 5.0% by weight, preferably 0.05% to 3.0% by weight 0.0% by weight, and even more preferably 0.1% to 1.0% by weight of at least one electrolyte; and / or optionally containing 0.01% to 5.0% by weight, preferably 0.1% to 3.0% by weight, and even more preferably 0.4% to 1.0% by weight of at least one preservative or preservative-enhancing ingredient; and / or optionally containing 0.01% to 20% by weight, preferably 0.1% to 10% by weight, and even more preferably 0.5% to 5.0% by weight of at least one further auxiliary agent.

[0313] Embodiment 88 provides a cosmetic composition according to embodiment 87, wherein the composition has a pH value of 2.0 to 10.0, preferably 3.0 to 8.0, and even more preferably 4.0 to 7.0.

[0314] Embodiment 89 provides the cosmetic composition according to any one of embodiments 34 to 83, wherein the composition is a sun care composition, such as a sun spray, sun milk, sun lotion, sun gel; and for example optionally comprises 0.1 wt.-% to 15 wt.-%, preferably 0.5 wt.-% to 10 wt.-%, even more preferably 1.0 wt.-% to 5.0 wt.-% of at least one emulsifier, co-emulsifier and / or solubilizer; and / or optionally comprises 0.001 wt.-% to 50 wt.-%, preferably 0.05 wt.-% to 40 wt.-%, even more preferably 0.1 wt.-% to 30 wt.-% of at least one oily substance; and / or optionally comprises 0.001 wt.-% to 30 wt.-%, preferably 0.05 wt.-% to 20 wt.-%, even more preferably 0.05 wt.-% to 50 wt.-%, 0.1% to 10% by weight, most preferably 0.05% to 5.0% by weight, of at least one sunscreen and / or UV blocker; and / or optionally 0.1% to 10% by weight, preferably 0.5% to 7.5% by weight, even more preferably 1.0% to 5.0% by weight of at least one film-forming agent; and / or optionally 0.01% to 5.0% by weight, preferably 0.1% to 3.0% by weight, even more preferably 0.4% to 1.0% by weight of at least one preservative or preservative-boosting ingredient; and / or optionally 0.01% to 20% by weight, preferably 0.1% to 10% by weight, even more preferably 0.5% to 5.0% by weight of at least one further adjuvant.

[0315] Embodiment 90 provides the cosmetic composition according to embodiment 89, wherein the composition has a pH value of 3.0 to 9.0, preferably 4.0 to 8.0, and even more preferably 5.0 to 7.0.

[0316] Embodiment 91 is the cosmetic composition according to any one of embodiments 34 to 83, wherein the composition is a face toner; and, for example, optionally comprises 0.001 wt.% to 5.0 wt.%, preferably 0.05 wt.% to 3.0 wt.%, even more preferably 0.1 wt.% to 1.0 wt.% of at least one skin conditioning agent; and / or optionally comprises 0.01 wt.% to 15 wt.%, preferably 0.1 wt.% to 10 wt.%, even more preferably 0.5 wt.% to 5.0 wt.% of at least one skin conditioning agent. % of at least one viscosity modifier or thickener; and / or optionally comprising 0.01 wt. % to 5.0 wt. %, preferably 0.1 wt. % to 3.0 wt. %, and even more preferably 0.4 wt. % to 1.0 wt. % of at least one preservative or preservative-boosting ingredient; and / or optionally comprising 0.01 wt. % to 20 wt. %, preferably 0.1 wt. % to 10.0 wt. %, and even more preferably 0.5 wt. % to 5.0 wt. % of at least one further auxiliary agent.

[0317] Embodiment 92 provides the cosmetic composition according to embodiment 91, wherein the composition has a pH value of 3.0 to 9.0, preferably 4.0 to 8.0, and even more preferably 5.0 to 7.0.

[0318] Embodiment 93 provides the cosmetic composition according to any one of embodiments 34 to 83, wherein the composition is a bar soap or synthetic detergent composition; and, for example, optionally comprises 1.0 wt. % to 50 wt. %, preferably 2.0 wt. % to 30 wt. %, even more preferably 5.0 wt. % to 20 wt. % of at least one surfactant; and / or optionally comprises 0.01 wt. % to 20 wt. %, preferably 0.05 wt. % to 15 wt. %, even more preferably 0.5 wt. % to 10 wt. % of at least one particulate material; and / or optionally comprises 0.001 wt. % to 5.0 wt. %, preferably 0.05 wt. % to 3.0 wt. %, even more preferably 0.1 wt. % to 1.0 wt. % of at least one electrolyte; and / or optionally comprises 0.01 wt. % to 20 wt. %, preferably 0.1 wt. % to 10 wt. % of at least one further adjuvant.

[0319] Embodiment 94 provides the cosmetic composition according to embodiment 93, wherein the composition has a pH value of 3.0 to 13.0, preferably 4.0 to 12.0, and even more preferably 5.0 to 10.0.

[0320] Embodiment 95 is the cosmetic composition according to any one of embodiments 34 to 83, wherein the composition is suitable for wet wipes; and for example optionally comprises 0.1 wt.-% to 10 wt.-%, preferably 0.3 wt.-% to 5.0 wt.-%, even more preferably 0.5 wt.-% to 3.0 wt.-% of at least one emulsifier, co-emulsifier and / or solubilizer; and / or optionally comprises 0.001 wt.-% to 30 wt.-%, preferably 0.05 wt.-% to 20 wt.-%, even more preferably 0.1 and / or optionally comprising 0.01% to 5.0% by weight, preferably 0.1% to 3.0% by weight, and even more preferably 0.4% to 1.0% by weight of at least one preservative or preservative-boosting ingredient; and / or optionally comprising 0.01% to 20% by weight, preferably 0.1% to 10% by weight, and even more preferably 0.5% to 5.0% by weight of at least one further auxiliary agent.

[0321] Embodiment 96 provides the cosmetic composition according to embodiment 95, wherein the composition has a pH value of 2.0 to 10, preferably 3.0 to 9.0, and even more preferably 4.0 to 8.0.

[0322] Embodiment 97 provides the cosmetic composition of any one of embodiments 34 to 83, wherein the composition is a deodorant and / or antiperspirant composition, for example in the form of a cream, roll-on, solid, aerosol, or gel; and optionally comprises, for example, 0.001 wt. % to 10 wt. %, or 0.01 wt. % to 9.0 wt. %, or 0.05 wt. % to 8.0 wt. %, or 0.1 wt. % to 5.0 wt. % of at least one antiperspirant and / or deodorant; and / or optionally comprises 0.01 wt. % to 3.0 wt. %, preferably 0.01 wt. % to 5.0 wt. %, ... Preferably, it contains 0.05% to 2.0% by weight, even more preferably 0.1% to 1.0% by weight, of at least one flavoring or fragrance ingredient; and / or optionally contains 0.5% to 60% by weight, preferably 1.0% to 50% by weight, even more preferably 2.0% to 40% by weight, of at least one propellant; and / or optionally contains 0.01% to 20% by weight, preferably 0.1% to 10% by weight, even more preferably 0.5% to 5.0% by weight of at least one further auxiliary agent.

[0323] Embodiment 98 provides the cosmetic composition according to embodiment 97, wherein the composition has a pH value of 2.0 to 8.0, preferably 3.0 to 7.0, and even more preferably 4.0 to 6.0.

[0324] Embodiment 99 is the cosmetic composition according to any one of embodiments 34 to 83, wherein the composition is a shaving composition; and, for example, optionally comprises 0.1 wt.-% to 10 wt.-%, preferably 0.3 wt.-% to 5.0 wt.-%, even more preferably 0.5 wt.-% to 3.0 wt.-%, of at least one emulsifier, co-emulsifier and / or solubilizer; and / or optionally comprises 0.001 wt.-% to 5.0 wt.-%, preferably 0.05 wt.-% to 3.0 wt.-%, even more preferably 0.1 wt.-% to 1.0 wt.-% of at least one skin conditioning agent; and / or and / or optionally comprising 0.5% to 60% by weight, preferably 1.0% to 50% by weight, and even more preferably 2.0% to 40% by weight of at least one propellant; and / or optionally comprising 0.1% to 20% by weight, preferably 0.3% to 10% by weight, and even more preferably 0.5% to 5.0% by weight of at least one surfactant; and / or optionally comprising 0.01% to 20% by weight, preferably 0.1% to 10% by weight, and even more preferably 0.5% to 5.0% by weight of at least one further auxiliary.

[0325] Embodiment 100 provides the cosmetic composition according to embodiment 99, wherein the composition has a pH value of 2.0 to 8.0, preferably 3.0 to 7.0, and even more preferably 4.0 to 6.0.

[0326] Embodiment 101 provides a cosmetic composition according to any one of embodiments 34 to 83 for use on the hair and / or scalp; for example, the composition is an emulsion or a gel, preferably an oil-in-water (o / w), cream gel, hydro-alcoholic gel or hydrogel composition.

[0327] Embodiment 102 provides the cosmetic composition of embodiment 101, wherein the hair care composition has a viscosity (25°C, Brookfield RVT, TC spindle, 20 revolutions per minute) of 100,000 to 150,000 mPa s, preferably 1,000 to 100,000 mPa s, more preferably 2,000 to 50,000 mPa s, and very preferably 5,000 to 30,000 mPa s.

[0328] Embodiment 103 provides the cosmetic composition according to embodiment 101 or 102, wherein the hair care composition is a shampoo; and, for example, optionally comprising 0.5% to 30% by weight, preferably 1.0% to 15% by weight, even more preferably 2.0% to 10% by weight of at least one surfactant; and / or optionally comprising 0.1% to 10% by weight, preferably 0.5% to 7.5% by weight, even more preferably 1.0% to 5.0% by weight of at least one cationic polymer; and / or optionally comprising 0.1% to 15% by weight, preferably 0.5% to 10% by weight, even more preferably 1.0% to 5.0% by weight of at least one pearlescent agent; and / or optionally comprising 0.001% to 5% by weight of at least one cationic polymer; 0.0% by weight, preferably 0.05% to 3.0% by weight, and even more preferably 0.1% to 1.0% by weight of at least one electrolyte; and / or optionally containing 0.01% to 15% by weight, preferably 0.1% to 10% by weight, and even more preferably 0.5% to 5.0% by weight of at least one viscosity modifier or thickener; and / or optionally containing 0.01% to 5.0% by weight, preferably 0.1% to 3.0% by weight, and even more preferably 0.4% to 1.0% by weight of at least one preservative or preservative-enhancing ingredient; and / or optionally containing 0.01% to 20% by weight, preferably 0.1% to 10% by weight, and even more preferably 0.5% to 5.0% by weight of at least one further auxiliary agent.

[0329] Embodiment 104 provides the cosmetic composition according to embodiment 101 or 102, wherein the hair care composition is a hair conditioning and / or hair and / or scalp treatment composition, such as a leave-in and rinse-off conditioner, a mask, a lotion, a combing cream, a detangling cream, an anti-frizz liquid, a hair serum, a scalp serum, a color protection cream; and, for example, optionally comprising 0.1 wt.-% to 15 wt.-%, preferably 0.5 wt.-% to 10 wt.-%, even more preferably 1.0 wt.-% to 5.0 wt.-%, of at least one emulsifier, co-emulsifier and / or solubilizer; and / or optionally comprising 0.01 wt.-% to 20 wt.-%, preferably 0.05 wt.-% to 10 wt.-%, even more preferably 0.1 wt.-% to 5.0 wt.-% of at least one oily substance; and and / or optionally comprising 0.1% to 10% by weight, preferably 0.5% to 7.5% by weight, even more preferably 1.0% to 5.0% by weight of at least one cationic polymer; and / or optionally comprising 0.001% to 5.0% by weight, preferably 0.01% to 3.0% by weight, even more preferably 0.1% to 2.0% by weight of at least one biogenic active substance; and / or optionally comprising 0.01% to 5.0% by weight, preferably 0.1% to 3.0% by weight, even more preferably 0.4% to 1.0% by weight of at least one preservative or preservative-boosting ingredient; and / or optionally comprising 0.01% to 20% by weight, preferably 0.1% to 10% by weight, even more preferably 0.5% to 5.0% by weight of at least one further auxiliary agent.

[0330] Embodiment 105 provides the cosmetic composition according to embodiment 101 or 102, wherein the hair care composition is a hair styling composition, such as a mousse, gel, spray, and wax; and, for example, optionally comprises 0.1 wt. % to 10 wt. %, preferably 0.5 wt. % to 7.5 wt. %, even more preferably 1.0 wt. % to 5.0 wt. % of at least one film former; and / or optionally comprises 0.1 wt. % to 10 wt. %, preferably 0.5 wt. % to 7.5 wt. %, even more preferably 1.0 wt. % to 5.0 wt. % of at least one cationic polymer; and and / or optionally comprising 0.5% to 60% by weight, preferably 1.0% to 50% by weight, and even more preferably 2.0% to 40% by weight of at least one propellant; and / or optionally comprising 0.01% to 5.0% by weight, preferably 0.1% to 3.0% by weight, and even more preferably 0.4% to 1.0% by weight of at least one preservative or preservative-boosting ingredient; and / or optionally comprising 0.01% to 20% by weight, preferably 0.1% to 10.0% by weight, and even more preferably 0.5% to 5.0% by weight of at least one further adjuvant.

[0331] Embodiment 106 is the cosmetic composition according to any one of embodiments 34 to 83, wherein the composition is a mouthwash composition; and, for example, optionally comprises 0.001 wt.% to 3.0 wt.%, preferably 0.01 wt.% to 2.0 wt.%, even more preferably 0.05 wt.% to 1.0 wt.% of at least one flavoring agent; and / or optionally comprises 0.1 wt.% to 6.0 wt.%, preferably 0.2 wt.% to 4.0 wt.%, even more preferably 0.3 wt.% to 2.0 wt.% of at least one solubilizer; and / or optionally comprises 0.001 wt.% to The present invention provides a cosmetic composition comprising 5.0 wt. %, preferably 0.05 wt. % to 3.0 wt. %, and even more preferably 0.1 wt. % to 1.0 wt. % of at least one electrolyte; and / or optionally comprising 0.01 wt. % to 5.0 wt. %, preferably 0.1 wt. % to 3.0 wt. %, and even more preferably 0.4 wt. % to 1.0 wt. % of at least one preservative or preservative-boosting ingredient; and / or optionally comprising 0.01 wt. % to 20 wt. %, preferably 0.1 wt. % to 10 wt. %, and even more preferably 0.5 wt. % to 5.0 wt. % of at least one further auxiliary agent.

[0332] Embodiment 107 provides the cosmetic composition according to embodiment 106, wherein the composition has a pH value of 2.0 to 10.0, preferably 3.0 to 9.0, and even more preferably 4.0 to 8.0.

[0333] Embodiment 108 relates to a care method for keratinous materials, comprising: (1) applying a cosmetic composition according to any one of embodiments 34 to 107 or an antimicrobial combination composition according to any one of embodiments 1 to 30 onto a keratin material; and (2) leaving the composition on the keratinous material for at least 1 hour;

[0334] Embodiment 109 provides a method according to embodiment 108, comprising applying a cosmetic composition according to any one of embodiments 34 to 107 onto a keratinous material; and allowing the composition to remain on the keratinous material for at least 1 hour.

[0335] Embodiment 120 provides a method according to embodiment 108 or 109, which does not include a rinsing step (e.g., by refraining from rinsing the treated skin for at least 1 hour, at least 2 hours, at least 4 hours, or at least 6 hours).

[0336] Embodiment 121 provides the use of an antimicrobial combination composition according to any one of embodiments 1 to 30 in the preservation of a cosmetic composition.

[0337] It is understood that the examples and embodiments described herein are for illustrative purposes only, and that various modifications or changes in light thereof will be suggested to those skilled in the art and are to be incorporated within the spirit and scope of this application and the appended claims. All publications, patents, and patent applications cited herein are hereby incorporated by reference for all purposes. The present application relates to the invention described in the claims, but may also include the following as other aspects. 1. A cosmetic composition for leave-on skin care use, having a pH in the range of 4 to 6, comprising: (a) one or more glycerol derivatives selected from the group consisting of 3-[(2-ethylhexyl)oxy]-1,2-propanediol, 3-[(n-octyl)oxy]-1,2-propanediol, and 3-[(2-octyl)oxy]-1,2-propanediol; and (b) one or more bicyclic compounds selected from the group consisting of 5,7-dihydroxy-2-(4-hydroxyphenyl)chroman-4-one (naringenin), 2-(3,4-dihydroxyphenyl)-3,5,7-trihydroxychromen-4-one (quercetin), 5,7-dihydroxy-2-(3-hydroxy-4-methoxyphenyl)chroman-4-one (hesperetin), and 5,7-dihydroxy-2-(3,4-dihydroxyphenyl)-chroman-4-one (eriodictyol). 2. The cosmetic composition according to claim 1, comprising less than 2.5% by weight of said one or more bicyclic compounds, or less than 3% by weight, or less than 1% by weight, or less than 0.5% by weight of said one or more bicyclic compounds, all based on the total weight of said one or more glycerol derivatives. 3. The cosmetic composition according to 1 or 2 above, having a pH in the range of 5.3 to 5.7, or a pH of about 5.5. 4. The cosmetic composition according to any one of 1 to 3 above, wherein the one or more glycerol derivatives include 3-[(2-ethylhexyl)oxy]-1,2-propanediol. 5. The cosmetic composition according to any one of 1 to 3 above, wherein the one or more glycerol derivatives include 3-[(n-octyl)oxy]-1,2-propanediol. 6. The cosmetic composition according to any one of 1 to 3 above, wherein the one or more glycerol derivatives include 3-[(2-octyl)oxy]-1,2-propanediol. 7. The cosmetic composition according to any one of 1 to 6 above, wherein the one or more bicyclic compounds include 5,7-dihydroxy-2-(4-hydroxyphenyl)chroman-4-one. 8. The cosmetic composition according to any one of 1 to 6 above, wherein the one or more bicyclic compounds include 2-(3,4-dihydroxyphenyl)-3,5,7-trihydroxychromen-4-one. 9. The cosmetic composition according to any one of 1 to 6 above, wherein the one or more bicyclic compounds include 5,7-dihydroxy-2-(3-hydroxy-4-methoxyphenyl)chroman-4-one. 10. The cosmetic composition according to any one of 1 to 6 above, wherein the one or more bicyclic compounds include 5,7-dihydroxy-2-(3,4-dihydroxyphenyl)-chroman-4-one. 11. Skin care regimens, including: a. applying the cosmetic composition according to any one of 1 to 10 above onto the skin; and b. leaving the composition on the skin for at least 1 hour. 12. The method of claim 11, which does not include a rinse-off step (e.g., by refraining from rinsing the treated skin for at least 1 hour, at least 2 hours, at least 4 hours, or at least 6 hours).

Claims

1. 1. A cosmetic composition for leave-on skin care use, having a pH in the range of 4 to 6, comprising: (a) one or more glycerol derivatives, including 3-[(n-octyl)oxy]-1,2-propanediol; and (b) one or more bicyclic compounds selected from the group consisting of 5,7-dihydroxy-2-(4-hydroxyphenyl)chroman-4-one (naringenin) and 2-(3,4-dihydroxyphenyl)-3,5,7-trihydroxychromen-4-one (quercetin); A cosmetic composition comprising: The cosmetic composition, wherein the one or more bicyclic compounds include 5,7-dihydroxy-2-(4-hydroxyphenyl)chroman-4-one.

2. 10. The cosmetic composition of claim 1, comprising less than 5% by weight of said one or more bicyclic compounds, based on the total weight of said one or more glycerol derivatives.

3. The cosmetic composition according to claim 1 or 2, which has a pH in the range of 5.3 to 5.

7.

4. The cosmetic composition according to any one of claims 1 to 3, wherein the one or more bicyclic compounds comprise 2-(3,4-dihydroxyphenyl)-3,5,7-trihydroxychromen-4-one.

5. Skin care regimens include: a. applying the cosmetic composition according to any one of claims 1 to 4 onto the skin; and b) leaving the composition on the skin for at least 1 hour.

6. The method of claim 5 , which does not include a rinsing step.

7. 10. The method of claim 6, wherein the method does not include a rinse-off step by refraining from rinsing the treated skin for at least one hour.

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