Microneedle vibrating applicator

Abstract

To provide a vibration applicator for a micro needle, capable of easily and precisely performing puncture by the micro needle by a simple configuration, and being excellent in operation ability and stability of operation.SOLUTION: There is provided a vibration applicator 10 for a micro needle which is used when pressing a micro needle array 12 to a surface of a skin 11 being an object, the vibration applicator comprises: an applicator main body 13 having a power source 16 and a switch 17 for switching on / off of the power source 16; and a head 14 arranged on a tip of the applicator main body 13 and having a vibrator 18 provided therein. In use, a tip face 14a of the head 14 is pressed against a surface of the skin 11 through the micro needle array 12, and by turning on the power source 16 by the switch 17, the vibrator 18 is driven and the micro needle array 12 is vibrated by the head 14.SELECTED DRAWING: Figure 1

Description

[Technical Field]

[0001] The present invention relates to a vibration-type applicator for microneedles that is used to administer medication into the body using a microneedle array instead of a syringe that has been conventionally used for medical or cosmetic purposes. [Background technology]

[0002] As the population continues to age and the birthrate declines, the role of medical care will increase, which is expected to lead to a shortage of hospitals and doctors. In addition to surgical treatment, medical procedures also include medication, and a large proportion of medication is administered internally via syringe. This medication is usually administered in a hospital by a qualified professional such as a doctor or nurse, but some medications, such as insulin for diabetes, are permitted to be administered by patients themselves at home. Therefore, if home medication, in which medication is administered at home based on a doctor's prescription, could be popularized, patients would need to visit hospitals less frequently, which would reduce the burden on doctors and patients (especially the elderly and working people), and interest in home medication is growing. There is a particularly great need for home medication in depopulated areas where there are problems with a shortage of hospitals and doctors.

[0003] However, while administering medication using a syringe has the advantage of being able to administer medication directly under the skin or into a blood vessel, it also has the disadvantage of being painful and causing skin damage and swelling as the number of doses increases. Therefore, instead of syringes, it has been considered to use a resin microneedle array with multiple microneedles (miniature needles) on a flat plate. The feature of this microneedle array is that the microneedles are long enough to reach the depth of the painless point under the skin, allowing painless administration of medication. Furthermore, patients can easily administer medication themselves by simply applying the patch to the epidermis, significantly reducing the burden on the patient. Furthermore, such microneedle arrays are expected to be used not only for medical purposes but also for cosmetic purposes. For the reasons described above, various studies have been conducted on applicators used to press microneedle arrays against the skin, with the aim of popularizing microneedle arrays. For example, Patent Documents 1 and 2 disclose applicators in which a cylindrical member and an actuation button are pressed with the fingers, respectively, to move a plunger and a piston in the axial direction against the force of a spring, thereby pressing a microneedle array (microneedle device) against the skin. However, such applicators require strong finger pressure when operating, making them difficult to use for women, the elderly, etc. Furthermore, these applicators apply impact when pressing the microneedle array, making them unsuitable for cosmetic microneedles used in delicate areas such as under the eyes, limiting their use. On the other hand, Patent Document 3 discloses a device (applicator) that converts electromagnetic vibrations generated by an electromagnetic oscillator into mechanical movement of an applicator head using an oscillator energy converter, and applies force to a microneedle array engaged with the applicator head. [Prior art documents] [Patent documents]

[0004] [Patent Document 1] Japanese Patent Application Publication No. 2018-191702 [Patent Document 2] Japanese Patent Application Publication No. 2018-102680 [Patent Document 3] Japanese Patent Application Laid-Open No. 2017-136437 Summary of the Invention [Problem to be solved by the invention]

[0005] The applicator in Patent Document 3 vibrates the applicator head and applies force to the microneedle array simply by switching it on, making it easy to use even for women and elderly people who have weak strength, and reducing labor. However, in Patent Document 3, electromagnetic vibrations generated by an electromagnetic oscillator are converted into mechanical motion of the applicator head by an oscillator energy converter, which has the problem of a complex structure, a large number of parts, and a high susceptibility to failure. Furthermore, if the microneedle is inserted too deeply, it may cause erythema to remain on the skin. Therefore, the amount of insertion of cosmetic microneedles must be kept small compared to medical microneedles, and it is desirable that the pressing force of the applicator be appropriately adjusted and controlled depending on the purpose or location of use, etc. The present invention has been made in consideration of the above circumstances, and aims to provide a vibration-type applicator for microneedles that has a simple configuration, is easy to operate, and has excellent operational stability, allowing for easy and proper puncture with a microneedle. [Means for solving the problem]

[0006] A microneedle vibration applicator according to the present invention that meets the above-mentioned objectives is a microneedle vibration applicator used when pressing a microneedle array against the surface of a target skin, comprising: The device comprises an applicator body having a power source and a switch for turning the power source on and off, and a head disposed at the tip of the applicator body and having a built-in vibrator; when in use, the tip surface of the head is pressed against the surface of the skin via the microneedle array, and the power source is turned on by the switch, which drives the vibrator and vibrates the microneedle array with the head. Here, the microneedle array may be placed on the surface of the target skin in advance, or may be attached (placed) at the tip of the head. When the microneedle array is attached to the tip of the head, the microneedle array may be attached directly to the tip surface of the head, or the microneedle array may be held by a holder (pressing member) attached to the tip of the head. By changing the holder depending on the size or shape of the substrate part of the microneedle array, a single microneedle vibration applicator can be used to handle various microneedle arrays.

[0007] In the microneedle vibration applicator according to the present invention, it is preferable that the applicator body has a cylindrical case in which the power source is housed, and that the push-button switch is attached to the base end of the case.

[0008] The vibrating applicator for microneedles according to the present invention may have a slide cover that is fitted onto the applicator body and slidably held on the applicator body, and during use, the tip surface of the head is pressed against the surface of the skin via the microneedle array, the slide cover slides relative to the applicator body, and the power supply is switched on when a force greater than a specified value is applied from the slide cover to the switch.

[0009] In the microneedle vibration applicator of the present invention, it is preferable that, during use, the tip end face of the slide cover abuts against the surface of the skin, thereby pressing the microneedle array against the surface of the skin with a constant pressing force.

[0010] In the microneedle vibration applicator of the present invention, the applicator body may be slidably connected to the head, and during use, the tip surface of the head is pressed against the surface of the skin via the microneedle array, the applicator body slides relative to the head, and the power supply may be switched on when a force greater than a specified value is applied from the applicator body to the switch.

[0011] In the vibrating applicator for microneedles according to the present invention, it is preferable that the applicator body has a pressure guide attached to the outer periphery at the tip thereof, and that when the applicator body slides over the head during use, the tip end face of the pressure guide abuts against the surface of the skin, thereby pressing the microneedle array against the surface of the skin with a constant pressure.

[0012] In the microneedle vibration applicator according to the present invention, the applicator body and the head may be connected via vibration isolation means.

[0013] In the microneedle vibration applicator of the present invention, it is preferable that the applicator body has a pressure guide attached to the outer periphery at the tip, and when in use, when the tip surface of the head is pressed against the surface of the skin via the microneedle array, the tip end surface of the pressure guide abuts against the surface of the skin, causing the microneedle array to be pressed against the surface of the skin with a constant pressure.

[0014] In the vibrating applicator for microneedles according to the present invention, it is further preferable that the pressing guide is replaceable, the mounting position of the pressing guide is changeable, or the overall length of the pressing guide is variable, so that the pressing force can be adjusted according to the distance from the tip end face of the pressing guide to the surface of the skin in the initial state.

[0015] The microneedle vibration applicator according to the present invention may comprise a pressing member that has a contact surface curved to correspond to the surface shape of the skin and is detachably attached to the tip of the head.

[0016] The microneedle vibration applicator according to the present invention may also include a timer that stops driving the vibrator after a predetermined time has elapsed since the power supply was switched on. [Effects of the Invention]

[0017] The microneedle vibration applicator of the present invention reliably performs punctures by driving the vibrator and vibrating the microneedle array with the head, making it easy to operate, labor-saving, and highly stable in operation.

[0018] In the vibrating applicator for microneedles according to the present invention, if the applicator body has a cylindrical case that houses the power supply and a push-button switch is attached to the base end of the case, the user can simply hold the case in their hand and press the switch with their thumb to turn on the power and drive the vibrator, making operation extremely easy.

[0019] The vibrating applicator for microneedles according to the present invention has a slide cover that is extrapolated onto the applicator body and slidably held on the applicator body; when in use, the tip surface of the head is pressed against the surface of the skin via the microneedle array, the slide cover slides relative to the applicator body, and when a force greater than a specified value is applied from the slide cover to the switch, the power is turned on; the user can vibrate the head simply by holding the slide cover in their hand and abutting the tip surface of the head against the base part of the microneedle array, and sliding the slide cover towards the skin, ensuring that the force with which the microneedle array is pressed against the skin is sufficient and puncture is carried out reliably and efficiently.

[0020] In the microneedle vibrating applicator of the present invention, when in use, the tip end face of the sliding cover abuts against the surface of the skin, and the microneedle array is pressed against the surface of the skin with a constant pressing force.A stable effect is obtained with an appropriate pressing force that is neither too much nor too little, and the pressing force can be adjusted appropriately by adjusting the amount of movement of the sliding cover depending on the purpose or location of use, etc.

[0021] In the microneedle vibration applicator of the present invention, the applicator body is slidably connected to the head, and when in use, the tip surface of the head is pressed against the surface of the skin via the microneedle array, the applicator body slides against the head, and when the power is turned on by the applicator body applying a force greater than or equal to a specified value to the switch, the user can vibrate the head simply by holding the applicator body in their hand and abutting the tip surface of the head against the base portion of the microneedle array, and sliding the applicator body toward the skin, so that the force with which the microneedle array is pressed against the skin is sufficient and puncture is carried out reliably and efficiently.

[0022] The vibrating applicator for microneedles according to the present invention has a pressure guide attached to the outer periphery of the tip of the applicator body, and when the applicator body slides over the head during use, the tip end face of the pressure guide abuts against the surface of the skin, so that when the microneedle array is pressed against the surface of the skin with a constant pressure, a stable effect is obtained with an appropriate pressure that is neither too much nor too little.

[0023] In the vibrating applicator for microneedles according to the present invention, when the applicator body and head are connected via vibration-damping means, vibrations from the head are less likely to be transmitted to the applicator body during use, and the microneedle array can be vibrated efficiently with a small force, facilitating puncture.

[0024] The vibrating applicator for microneedles according to the present invention has a pressure guide attached to the outer periphery of the tip of the applicator body, and when in use, the tip surface of the head is pressed against the surface of the skin via the microneedle array, so that the tip end surface of the pressure guide abuts against the surface of the skin, and when the microneedle array is pressed against the surface of the skin with a constant pressure, a stable effect is obtained with an appropriate pressure that is neither too much nor too little.

[0025] In the microneedle vibration applicator of the present invention, if the pressure guide is replaceable, the mounting position of the pressure guide is changeable, or the overall length of the pressure guide is variable, and the pressure force can be adjusted according to the distance from the tip end face of the pressure guide to the surface of the skin in the initial state, the pressure force can be appropriately adjusted according to the purpose or location of use, etc.

[0026] In the microneedle vibration applicator of the present invention, when it is equipped with a pressing member that has a contact surface curved to correspond to the surface shape of the skin and is detachably attached to the tip of the head, by replacing the pressing member according to the surface shape (location) of the target skin, the contact surface can be pressed evenly against the substrate portion of the microneedle array, allowing the microneedle array to adhere closely to the surface of the skin.

[0027] In the microneedle vibration applicator of the present invention, if a timer is provided that stops the drive of the vibrator a predetermined time after the power is turned on, the microneedle array can be vibrated just enough to perform efficient punctures in a short time. [Brief explanation of the drawings]

[0028] [Figure 1] 1 is a cross-sectional front view of a main part of a vibration type applicator for microneedles according to a first embodiment of the present invention. [Figure 2] FIG. 10 is a cross-sectional front view of a main part of a vibration type microneedle applicator according to a second embodiment of the present invention. [Figure 3]FIG. 10 is a cross-sectional front view of a main part of a vibration type microneedle applicator according to a third embodiment of the present invention. [Figure 4] FIG. 10 is a cross-sectional front view of a main part of a vibration type microneedle applicator according to a fourth embodiment of the present invention. DETAILED DESCRIPTION OF THE INVENTION

[0029] Next, embodiments of the present invention will be described with reference to the accompanying drawings. The microneedle vibration applicator 10 (hereinafter simply referred to as the applicator 10) according to the first embodiment of the present invention shown in Figure 1 is used to perform puncture by pressing a microneedle array 12, which is placed in advance on the surface of the skin 11 of a patient or the like, against the skin 11. As shown in Figure 1, applicator 10 includes applicator body 13 and head 14 located at the tip of applicator body 13. Applicator body 13 has a cylindrical case 15 that houses a power source 16. A push-button switch 17 for switching power source 16 on and off is attached to the base end of case 15. Head 14 contains a built-in vibrator 18, and power source 16, switch 17, and vibrator 18 are electrically connected by electric wires 19a, 19b, and 20. Therefore, during use, the tip surface 14a of the head 14 abuts against the substrate portion 12a of the microneedle array 12 and is pressed against the surface of the skin 11 via the microneedle array 12, and the power supply 16 is turned on with the switch 17 to drive the vibrator 18, causing the microneedle array 12 to vibrate with the head 14. As a result, the skin 11 is punctured effectively. Here, the vibrator 18 may be any vibrator capable of vibrating the microneedle array 12 in a direction perpendicular to the surface of the skin 11. For example, the vibration frequency is preferably 20 Hz to 40 kHz, but is not limited to this range and may be appropriately selected depending on the purpose of use, etc. The microneedle array may be placed on the target skin surface in advance, or may be attached (placed) to the tip of the head and pressed against the skin surface.

[0030] The outer diameter of the applicator body 13 (case 15) is large enough for a user to hold in one hand, and by pressing the switch 17 with, for example, the thumb, the power supply 16 can be easily turned on and the vibrator 18 can be driven, resulting in excellent labor-saving and operability. Here, the power supply 16 is preferably one that is turned on (energized) only while the switch 17 is pressed, but it may also be one that switches on and off each time the switch 17 is pressed. Furthermore, for example, a timer (not shown) may be provided in the applicator body 13 so that the driving of the vibrator 18 is stopped after a predetermined time has elapsed since the power supply 16 was switched on. In addition, in this embodiment, the tip surface 14a of the head 14 is formed flat, but the shape of the tip surface of the head can be selected appropriately to match the surface shape (unevenness and curvature) of the target skin. The applicator body and head may be made of metal or synthetic resin. At least the tip of the head may be made of soft synthetic rubber or the like, and may be deformed to conform to (follow) the surface shape of the skin. Alternatively, a pressing member (not shown) having a curved contact surface conforming to the surface shape of the skin may be removably attached to the tip of the head, as needed. To make the applicator body easier to grip, the outer periphery of the case may be formed with projections and recesses to conform to the shape of fingers, or a non-slip surface made of synthetic rubber or the like may be wrapped around it.

[0031] Next, a description will be given of a vibration-type applicator 23 for microneedles (hereinafter simply referred to as applicator 23) according to a second embodiment of the present invention shown in Fig. 2. Note that the same components as those in the first embodiment are given the same reference numerals and descriptions thereof will be omitted. 2 differs from applicator 10 in that it has a slide cover 24 that is fitted onto applicator body 13 (case 15) and slidably held on applicator body 13. This applicator 23 is configured such that, during use, tip surface 14a of head 14 is pressed against substrate portion 12a of microneedle array 12, and slide cover 24 slides relative to applicator body 13, and when slide cover 24 applies a force equal to or greater than a specified value to switch 17, power source 16 is switched on. Specifically, the slide cover 24 is formed into a cylindrical shape, and a coil spring 26 is installed between the top plate portion 25 and the switch 17. When the slide cover 24 slides, the coil spring 26 is compressed, and when a force greater than a specified value is applied, the switch 17 is pressed and the power supply 16 is switched on. In this embodiment, the coil spring 26 is always compressed by a constant amount when the tip end surface 24a of the slide cover 24 abuts against the skin 11, so that the microneedle array 12 can be vibrated with the tip end surface 14a of the head 14 pressed against the substrate portion 12a of the microneedle array 12 with a constant force (for example, 0.1 to 3 kg). Therefore, the microneedle array 12 is pressed against the surface of the skin 11 with a constant pressing force, neither too much nor too little. The pressing force at this time can be adjusted by appropriately selecting the length of the slide cover 24 (the distance from the end surface 24a to the skin 11), the length of the coil spring 26 (the distance from the top plate portion 25 to the switch 17), or the spring constant of the coil spring 26.

[0032] The structure in which the power is switched on when a force equal to or greater than a specified value is applied to the switch from the sliding cover is not limited to this embodiment. For example, other elastic members may be used instead of the coil spring, and the position of the switch and the shape of the sliding cover may be selected as appropriate. In this embodiment, rolling elements (balls) 27 are arranged at key points on the outer circumferential surface of case 15 and are brought into contact with the inner circumferential surface of cylindrical portion 28 of slide cover 24 so that slide cover 24 can slide smoothly relative to applicator body 13 (case 15), but the number and arrangement of rolling elements can be selected appropriately. For example, rolling elements may be arranged at key points on the inner circumferential surface of the cylindrical portion of the slide cover and brought into contact with the outer circumferential surface of the case, or the applicator body (case) and slide cover may be arranged coaxially by guide means other than rolling elements. The material of the slide cover may be metal or synthetic resin, and may be the same as or different from the applicator body.

[0033] Next, a description will be given of a vibration-type applicator 30 for microneedles (hereinafter simply referred to as applicator 30) according to a third embodiment of the present invention shown in Fig. 3. Note that the same components as those in the first and second embodiments are given the same reference numerals and their description will be omitted. 3 differs from the applicator 10 in that an applicator body 32 is slidably connected to a head 31, and that a cylindrical pressing guide 33 is provided on the outer periphery of the tip of the applicator body 32. When the applicator 30 is in use, the tip surface 31a of the head 31 abuts against the substrate 12a of the microneedle array 12 and is pressed against the surface of the skin 11 via the microneedle array 12, the applicator body 32 slides relative to the head 31, and when a force equal to or greater than a specified value is applied from the applicator body 32 to the switch 34, the power supply 16 is switched on.

[0034] Here, the head 31 has a head main body 35 in which the vibrator 18 is built, a cylindrical sliding portion 36 formed on the base side of the head main body 35, a flange portion 37 formed on the outer periphery of the base side of the sliding portion 36, and a protrusion portion 38 formed on the base side end of the sliding portion 36. Lead wires 39a, 39b of the vibrator 18 pass through the inside of the sliding portion 36, and contact portions 40a, 40b provided at the tips of the lead wires 39a, 39b are fixed to the base side surface of the flange portion 37. Furthermore, a bottom plate 43 of a case 42 of the applicator body 32, which houses the power source 16, is formed with an insertion hole 44 through which the sliding portion 36 is inserted, and a partition member 45 is attached inside the case 42, facing the flange portion 37 and the protrusion 38. Electric wires 46a, 46b connected to the power source 16 pass through the partition member 45, and spring terminals 47a, 47b provided at the ends of the electric wires 46a, 46b are fixed to the front surface of the partition member 45 so as to be spaced apart from and opposite the contact portions 40a, 40b. A recess 48 is formed in the center of the front surface of the partition member 45, facing the protrusion 38, and a biasing spring 49 that abuts against the protrusion 38 is housed inside the recess 48.

[0035] The switch 34 is composed of the contact portions 40a, 40b, the partition member 45, the spring terminals 47a, 47b, and the biasing spring 49 described above. In other words, when the applicator body 32 slides relative to the head 31 and the biasing spring 49 housed in the recess 48 is compressed by the protrusion 38 and a force equal to or greater than a specified value is applied, the contact portions 40a, 40b come into contact with the spring terminals 47a, 47b, and the power supply 16 is switched on. At this time, the tip end face 33a of the pressing guide 33 abuts against the surface of the skin 11, so that the biasing spring 49 is always compressed by a constant amount, and the microneedle array 12 is pressed against the surface of the skin 11 with a constant pressing force. This provides the same effects and advantages as the applicator 23. In this embodiment, the pressure guide 33 is formed in a cylindrical shape so as to surround the outer periphery of the head 31, but the pressure guide may be formed intermittently in the circumferential direction or may be omitted.

[0036] The structure in which the power is switched on when a force equal to or greater than a specified value is applied to the switch from the sliding applicator body is not limited to this embodiment. For example, the contact portion and the spring terminal may be interchanged, or a leaf spring may be used as the spring terminal instead of a coil spring. Furthermore, the distance from the tip end surface 33a of the pressing guide 33 to the surface of the skin 11 in the initial state (at the start of use) can be selected (changed), and the pressing force can be adjusted according to that distance. For example, a plurality of pressing guides with different overall lengths (axial dimensions) may be prepared and replaced, or pressing guides may be attached to different positions in the axial direction of the applicator body (the up-and-down direction in FIG. 3 ) and the attachment position of the pressing guide may be changed, or a pressing guide with a variable overall length may be attached. The pressing guide is attached to the applicator body by fitting or screwing (screw engagement), etc. As a structure for changing the overall length of the pressing guide, a pressing guide having a fixed part fixed to the applicator body and a movable part threadedly engaged with the fixed part and held so as to be able to advance and retreat in the axial direction of the fixed part (applicator body) is preferably used, but is not limited to this.

[0037] Next, a description will be given of a vibration type applicator 51 for microneedles (hereinafter simply referred to as applicator 51) according to a fourth embodiment of the present invention shown in Fig. 4. Note that the same components as those in the first to third embodiments are given the same reference numerals and description thereof will be omitted. The applicator 51 shown in FIG. 4 comprises an applicator body 52 and a head 53 connected via vibration isolation means 54 . In this embodiment, a compression coil spring is extrapolated to the sliding portion 36 as vibration-damping means 54, and when the head body 35 vibrates due to the driving of the vibrator 18, the vibration-damping means 54 sandwiched between the head body 35 and the bottom plate portion 43 of the case 42 expands and contracts. Therefore, during use, when the tip surface 53a of the head 53 abuts against the substrate portion 12a of the microneedle array 12 and is pressed against the surface of the skin 11 via the microneedle array 12, and the power supply 16 is turned on with the switch 17 to drive the vibrator 18, and the microneedle array 12 is vibrated by the head 53, it is possible to prevent the vibration of the head 53 from being transmitted to the applicator body 52. ​​As a result, the vibrator 18 can efficiently vibrate the microneedle array 12 with a small force, facilitating puncture. At this time, as with the applicator 30, the pressing force with which the microneedle array 12 is pressed against the surface of the skin 11 can be kept constant by the action of the pressing guide 33, but the pressing guide 33 may be omitted. The vibration-isolating means may be any means capable of preventing the vibration of the head from being transmitted to the applicator body, and the structure thereof is not limited to that of this embodiment, but may be selected as appropriate.

[0038] The above describes an embodiment of the present invention, but the present invention is not limited to the configurations described in the above embodiment, and also includes other embodiments and modifications that are possible within the scope of the matters described in the claims. [Explanation of symbols]

[0039] 10: Microneedle vibration applicator, 11: Skin, 12: Microneedle array, 12a: Base plate, 13: Applicator body, 14: Head, 14a: Tip surface, 15: Case, 16: Power supply, 17: Switch, 18: Vibrator, 19a, 19b, 20: Electric wire, 23: Microneedle vibration applicator, 24: Slide cover, 24a: End surface, 25: Top plate, 26: Coil spring, 27: Rolling element, 28: Cylindrical portion, 30: Microneedle vibration applicator, 31: Head, 31a : Tip surface, 32: Applicator body, 33: Pressing guide, 33a: End surface, 34: Switch, 35: Head body, 36: Sliding portion, 37: Flange portion, 38: Protrusion portion, 39a, 39b: Lead wire, 40a, 40b: Contact portion, 42: Case, 43: Bottom plate portion, 44: Insertion hole, 45: Partition member, 46a, 46b: Electric wire, 47a, 47b: Spring terminal, 48: Recess, 49: Biasing spring, 51: Microneedle vibration applicator, 52: Applicator body, 53: Head, 53a: Tip surface, 54: Vibration isolation means

Claims

1. A microneedle vibration applicator is used when pressing a microneedle array against the surface of target skin, and comprises an applicator body having a power source and a switch for switching the power source on and off, and a head that is disposed at the tip of the applicator body and has a built-in vibrator, wherein, in use, the tip surface of the head is pressed against the surface of the skin via the microneedle array, and the power source is switched on by the switch to drive the vibrator, causing the microneedle array to vibrate with the head, A vibrating applicator for microneedles, characterized in that it has a slide cover that is fitted onto the applicator body and slidably held on the applicator body, and when in use, the slide cover slides relative to the applicator body, and the power supply is turned on when a force greater than a specified value is applied from the slide cover to the switch.

2. 2. The microneedle vibration applicator according to claim 1, wherein, when in use, the tip end face of the slide cover abuts against the surface of the skin, thereby pressing the microneedle array against the surface of the skin with a constant pressing force.

3. A microneedle vibration applicator is used when pressing a microneedle array against the surface of target skin, and comprises an applicator body having a power source and a switch for switching the power source on and off, and a head that is disposed at the tip of the applicator body and has a built-in vibrator, wherein, in use, the tip surface of the head is pressed against the surface of the skin via the microneedle array, and the power source is switched on by the switch to drive the vibrator, causing the microneedle array to vibrate with the head, The applicator body is slidably connected to the head, and has a pressure guide attached to the outer periphery of the tip of the applicator body; when the applicator body slides over the head in use, the tip end face of the pressure guide abuts against the surface of the skin, causing the microneedle array to be pressed against the surface of the skin with a constant pressure; and the pressure guide is replaceable, the attachment position of the pressure guide is changeable, or the overall length of the pressure guide is variable, so that the pressure can be adjusted depending on the distance from the tip end face of the pressure guide to the surface of the skin in the initial state.

4. 4. The microneedle vibration applicator according to claim 3, wherein, during use, the applicator body slides against the head, and the power supply is switched on when a force equal to or greater than a specified value is applied from the applicator body to the switch.

5. A microneedle vibration applicator is used when pressing a microneedle array against the surface of target skin, and comprises an applicator body having a power source and a switch for switching the power source on and off, and a head that is disposed at the tip of the applicator body and has a built-in vibrator, wherein, in use, the tip surface of the head is pressed against the surface of the skin via the microneedle array, and the power source is switched on by the switch to drive the vibrator, causing the microneedle array to vibrate with the head, A vibration-type applicator for microneedles, characterized in that it has a pressure guide attached to the outer periphery of the tip side of the applicator body, and when in use, the tip end face of the pressure guide abuts against the surface of the skin, thereby pressing the microneedle array against the surface of the skin with a constant pressure, and the pressure guide is replaceable, the attachment position of the pressure guide is changeable, or the overall length of the pressure guide is variable, so that the pressure can be adjusted depending on the distance from the tip end face of the pressure guide to the surface of the skin in the initial state.

6. 6. The microneedle vibration applicator according to claim 5, wherein the applicator body and the head are connected via vibration isolation means.

7. The vibrating applicator for microneedles according to any one of claims 1 to 6, characterized in that it comprises a pressing member having a contact surface curved to correspond to the surface shape of the skin and removably attached to the tip of the head.

8. 8. The microneedle vibration applicator according to claim 1, further comprising a timer that stops the driving of the vibrator after a predetermined time has elapsed since the power supply was turned on.

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