Antibacterial composition

Abstract

To provide compositions having an antimicrobial effect, comprising ingredients having a minor impact on the overall perfume profile of a product in which the composition is added while maintaining or even improving the efficacy of the composition.SOLUTION: A composition comprises a perfume ingredient and, for example, a combination of heliopropanal, nerol, phenylhexanol, and tetralinol, a combination of anisic aldehyde, heliotropin, and terpineol, or a combination of decal, isoeugenol, perycorolle, and tetralinol.SELECTED DRAWING: None

Description

[Technical Field]

[0001] CROSS-REFERENCE TO RELATED APPLICATIONS This application claims priority to International Patent Application No. PCT / CN2018 / 079526, filed March 20, 2018, the entire contents of which are incorporated herein by reference in their entirety.

[0002] Field The present disclosure relates to the field of antimicrobial compositions and their use as antimicrobial agents, or antimicrobially active fragrance compositions and their use for the manufacture of consumer products.

[0003] background Hygiene, in its fullest sense, is a broad subject that goes beyond mere "cleanliness" to include all the circumstances and practices, lifestyle habits and assumptions that create and foster a safe and healthy environment, in addition to products, processes and devices. In particular, hygiene refers to the conditions and practices that are conducive to maintaining health and preventing the spread of disease, and thus includes a specific set of practices related to maintaining this health, such as environmental cleaning, equipment, hand hygiene, sterilization of water and sanitation facilities, or the safe disposal of medical waste.

[0004] In order to improve hygiene, compositions with antibacterial effects have been developed.However, the most currently used biocides, such as triclocarban and triclosan, are questioned by consumers and / or authorities because these products are suspected of being endocrine disruptors.Therefore, it is necessary to find antibacterial ingredients that have no or low side effects while maintaining good antibacterial activity.

[0005] In one example, US Pat. No. 7,759,058 discloses an antimicrobial composition comprising at least 30% by weight of one or more perfume ingredients including nona-2,6-dien-1-ol.

[0006] In another example, WO2005079573 reports a fragrance composition that, as expected, not only provides a sensory stimulating effect but also antifungal activity in the vapor phase. The antifungal composition comprises at least two perfume ingredients selected from a list of ingredients including, inter alia, 2,6-nonadienol and thymol, in an amount of at least 50% by weight of the total composition. However, according to this teaching, in order to impart antibacterial properties, a large amount of perfume ingredients is required, which significantly affects the odor profile of the final product containing these compositions, thus limiting their use as antibacterial agents.

[0007] In another example, U.S. Patent No. 9,339,477 discloses an antimicrobial composition for personal cleaning, oral care, or hard surface cleaning applications, wherein a composition comprising thymol, selected propen-2-yl-methyl-cyclohexanol, and a carrier was found to provide synergistic antimicrobial activity.

[0008] In another example, U.S. Pat. No. 5,453,276 discloses an antimicrobial composition for controlling P. aeruginosa or P. acnes comprising an indole and a natural substance selected from the group consisting of anacardic acid, limonene, β-pinene, farnesol, β-citronellol, pine resin, hinokitiol, longifolene, and β-caryophyllene.

[0009] However, despite the availability of antibacterial compounds and compositions, there remains a continuing need to find alternative antibacterial compositions and active compounds suitable for use in such compositions. Without intending to be limited to any particular theory, the availability of alternatives can reduce the risk of microbial resistance and / or insensitivity to certain antibacterial compounds.

[0010] Therefore, there remains a need to provide compositions with antimicrobial efficacy that contain ingredients that only marginally impact the overall perfume profile of the product to which the composition is added, while maintaining or even improving the efficacy of the composition in order to shorten the contact time required for effective antimicrobial action.

[0011] The present disclosure provides a solution to the above-mentioned problems by using a composition comprising a perfume ingredient as an antimicrobial agent, which can provide significant antimicrobial effect at low concentrations of the perfume ingredient.

[0012] overview In one aspect, the present disclosure provides a composition comprising a perfume ingredient, the composition being selected from the group consisting of: i. 3-(1,3-benzodioxol-5-yl)-2-methylpropanal (hereinafter "heliopropanal"), (Z)-3,7-dimethyl-2,6-octadien-1-ol (hereinafter "nerol"), phenylhexanol, and 3,7-dimethyl-3-octanol (hereinafter "tetralinol"); ii. 4-methoxybenzaldehyde (hereinafter "anisaldehyde"), 1,3-benzodioxole-5-carbaldehyde (hereinafter "heliotropin"), and 2-(4-methylcyclohex-3-en-1-yl)propan-2-ol (hereinafter "terpineol"); iii. Anisaldehyde, heliotropin, terpineol, and heliopropanal; iv. γ-dodecalactone (hereinafter "decal"), 2-methoxy-4-(prop-1-en-1-yl)phenol (hereinafter "isoeugenol"), (S)-(-)-(4-isopropenyl-1-cyclohexenyl)methanol (hereinafter "pericolore"), and tetralinol; v. Phenylhexanol, terpineol, and isoeugenol; vi. phenylhexanol, terpineol, isoeugenol, and 2H-chromen-2-one (hereafter "coumarin"); vii. 2-methoxy-4-(prop-2-en-1-yl)phenol (hereinafter "eugenol F"), phenylhexanol, and dimethylphenylethylcarbinol (hereinafter "carbinol muguet"); and viii. Eugenol F, phenylhexanol, carbinol muguet, and benzyl acetate, wherein these perfume ingredients are present in the composition in an amount sufficient to provide an antimicrobial effect.

[0013] In one embodiment, the composition provides an antibacterial effect through inactivation of bacterial cells, hi one embodiment, the bacterial cells comprise a bacterial strain selected from the group consisting of Corynebacterium xerosis, Pseudomonas aeruginosa, Salmonella enterica, Staphylococcus haemolyticus, Staphylococcus aureus, and Escherichia coli.

[0014] In one aspect, the present invention provides a method comprising treating a substrate containing microorganisms with an effective amount of a composition according to some aspects of the present disclosure to provide an antimicrobial effect.

[0015] In one embodiment, the composition comprises heliopropanal, nerol, phenylhexanol, and tetralinol. In one embodiment, the ratio of heliopropanal, nerol, phenylhexanol, and tetralinol is 6:3:5:6. In one embodiment, the effective amount of the composition to provide an antimicrobial effect is 0.05 to 0.5% w / v.

[0016] In one embodiment, the composition comprises anisaldehyde, heliotropin, and terpineol. In one embodiment, the ratio of anisaldehyde, heliotropin, and terpineol is 13:20:3. In one embodiment, the effective amount of the composition to provide an antimicrobial effect is 0.3-0.6% w / v.

[0017] In one embodiment, the composition comprises anisaldehyde, heliotropin, terpineol, and heliopropanal. In one embodiment, the ratio of anisaldehyde, heliotropin, terpineol, and heliopropanal is 13:20:3:20. In one embodiment, the effective amount of the composition to provide an antimicrobial effect is 0.2-0.5% w / v.

[0018] In one embodiment, the composition comprises decal, isoeugenol, pericolor, and tetralinol. In one embodiment, the ratio of decal, isoeugenol, pericolor, and tetralinol is 2:1:5:2. In one embodiment, the effective amount of the composition to provide an antimicrobial effect is 0.05-0.5% w / v.

[0019] In one embodiment, the composition comprises phenylhexanol, terpineol, and isoeugenol. In one embodiment, the ratio of phenylhexanol, terpineol, and isoeugenol is 2:5:5. In one embodiment, the effective amount of the composition to provide an antimicrobial effect is 0.06-0.5% w / v.

[0020] In one embodiment, the composition comprises phenylhexanol, terpineol, isoeugenol, and coumarin. In one embodiment, the ratio of phenylhexanol, terpineol, isoeugenol, and coumarin is 5:1:1:2. In one embodiment, the effective amount of the composition to provide an antimicrobial effect is 0.03-0.5% w / v.

[0021] In one embodiment, the composition comprises eugenol F, phenylhexanol, and carbinol lily of the valley. In one embodiment, the ratio of eugenol F, phenylhexanol, and carbinol lily of the valley is 1:5:10. In one embodiment, the effective amount of the composition to provide an antimicrobial effect is 0.06-0.5% w / v.

[0022] In one embodiment, the composition comprises eugenol F, phenylhexanol, carbinol lily of the valley, and benzyl acetate. In one embodiment, the ratio of eugenol F, phenylhexanol, carbinol lily of the valley, and benzyl acetate is 1:5:10:10. In one embodiment, the effective amount of the composition to provide an antimicrobial effect is 0.1-0.6% w / v.

[0023] In one embodiment, the composition comprises phenylhexanol and at least one fragrance ingredient selected from the group consisting of heliopropanal, nerol, tetralinol, isoeugenol, terpineol, coumarin, eugenol F, carbinol lily of the valley, and benzyl acetate.

[0024] In one embodiment, the composition comprises anisaldehyde and at least one fragrance ingredient selected from the group consisting of heliotropin, terpineol, and heliopropanal.

[0025] In one embodiment, the effective amount of phenylhexanol in the composition is 500 to 6000 ppm.

[0026] In one embodiment, the effective amount of heliopropanal in the composition is 2000 to 6000 ppm.

[0027] In one embodiment, the effective amount of tetralinol in the composition is 1000 to 4000 ppm.

[0028] In one embodiment, the effective amount of isoeugenol in the composition is 500 to 3000 ppm.

[0029] In one embodiment, the effective amount of terpineol in the composition is 500 to 3000 ppm.

[0030] In one embodiment, the effective amount of coumarin in the composition is 1000 to 3000 ppm.

[0031] In one embodiment, the effective amount of eugenol F in the composition is 200 to 1000 ppm.

[0032] In one embodiment, the effective amount of carbinol lily of the valley in the composition is 4000 to 7000 ppm.

[0033] In one embodiment, the effective amount of benzyl acetate in the composition is 4000 to 6000 ppm.

[0034] In one embodiment, the effective amount of anisaldehyde in the composition is 2500 to 4500 ppm.

[0035] In one embodiment, the effective amount of heliotropin in the composition is 4000 to 6000 ppm.

[0036] In one embodiment, the effective amount of decal in the composition is 1000 to 3000 ppm.

[0037] In one embodiment, the effective amount of pericolor in the composition is 4000 to 6000 ppm.

[0038] In one embodiment, the composition further comprises at least one ingredient selected from the group consisting of perfume carriers, perfume adjuncts, and mixtures thereof; and optionally at least one perfume adjunct.

[0039] In one embodiment, the composition is formulated as a consumer product, wherein the consumer product is a fragrance, a fabric care product, a body care product, a cosmetic, a skin care product, an air care product, or a home care product. In one embodiment, the consumer product is a fine perfume, a splash or eau de parfum, a cologne, a shaving or aftershave lotion, a liquid or solid detergent, a fabric softener, a fabric refresher, ironing water, paper, bleach, a carpet cleaner, a curtain care product, a shampoo, a color preparation, a color care product, a hair shaping product, a dental care product, a disinfectant, an intimate care product, a hairspray, a vanishing cream, a deodorant or antiperspirant, a depilatory, a tanning or sun product, a nail product, a skin cleanser, a makeup product, a scented soap, a shower or bath mousse, an oil or gel, a foot / hand care product, a hygiene product, an air freshener, a "ready to use" powder air freshener, a mold remover, furniture care, a wipe, a dish detergent or hard surface cleaner, a leather care product, or a car care product. [Brief explanation of the drawings]

[0040] [Figure 1] 1 shows the effect of a deodorant preparation comprising a composition according to some embodiments of the present disclosure on reducing the growth of C. xerosis strains as determined using a BCT test according to the method described in Examples 1 and 2. [Figure 2] 1 shows the in vivo effects of test deodorant formulations, including compositions according to some embodiments of the present disclosure, on malodor formation and bacterial growth 4 hours after application to a subject's skin. [Figure 3] 1 shows the in vivo effects of test deodorant formulations, including compositions according to several embodiments of the present disclosure, on malodor formation and bacterial growth 8 hours after application to a subject's skin.

[0041] Detailed Description In the following description, reference is made to specific embodiments that can be practiced, which are illustrated by way of example. These embodiments are described in sufficient detail to enable one skilled in the art to practice the invention described herein, and it is understood that other embodiments may be utilized and logical changes may be made without departing from the scope of the embodiments described herein. Therefore, the following description of exemplary embodiments should not be taken in a limiting sense, and the scope of the various embodiments described herein is defined by the appended claims.

[0042] The Abstract is provided pursuant to 37 CFR §1.72(b) to allow the reader to quickly ascertain the nature and gist of the technical disclosure. The Abstract is submitted with the understanding that it will not be used to interpret or limit the scope or meaning of the claims.

[0043] As shown in the examples below, the compositions provided herein demonstrate antimicrobial efficacy. In some embodiments, the antimicrobial effect is bactericidal, where bacterial cells are inactivated or killed. Alternatively, in some embodiments, the antimicrobial effect is bacteriostatic, where the rate of bacterial cell growth is reduced, suppressed, or inhibited.

[0044] According to particular embodiments, the composition provides a synergistic antimicrobial effect, i.e., an effect that is greater than the simple sum or addition of the antimicrobial effects that would be expected if the components of the composition were mixed at the desired concentrations, in other words, in such cases the antimicrobial activity of the combined components is greater than the sum of the activities of the individual components.

[0045] With reference to Examples 1-3 below, the synergistic effects of the fragrance ingredients in the antimicrobial combinations shown herein were discovered by testing a wide range of concentrations (doses) of the individual fragrance ingredients and mixtures and by observing the bactericidal effects against the noted bacterial strains (Corynebacterium xerosis, Pseudomonas aeruginosa, Salmonella enterica, Staphylococcus haemolyticus, Staphylococcus aureus, and Escherichia coli). Determination of the synergistic effects of compositions containing three or more fragrance ingredients was performed using the combination index (CI) method for multidrug systems as described by Chou, T., Pharmaceutical Reviews 58:621-681 (2006). The CI method determines synergy or antagonism based on the law of mass action.

[0046] The dose-effect relationship for each drug is described by the following median effect formula: D=D m [f a / (1-f a )] l / m During the ceremony, D is a certain degree of effect (f a ) is a dose having; D m is the 50% effective dose; m is a coefficient that describes the shape of the dose-effect relationship.

[0047] The general formula for the combination index (CI) for n drug combinations at x% efficacy is:

number

[0048] The table below shows the CI values ​​associated with antagonistic, additive, and synergistic effects. [Table 1]

[0049] The use of compositions as defined herein is particularly advantageous for the inactivation of microorganisms such as bacteria. Antimicrobial efficacy is one of the primary requirements for hygiene products, such as body care or home care products. The antimicrobial efficacy of the compositions provided herein may be determined using any method readily selected by one skilled in the art. One example of a method for determining the antimicrobial efficacy of the compositions provided herein is determining the efficacy of bacterial inactivation after contacting bacteria with the antimicrobial composition (also referred to herein as the bacterial contact time (BCT) test). Examples 1-3 below describe the BCT test that was utilized.

[0050] In some aspects, the present disclosure provides a composition comprising a perfume ingredient, the composition being selected from the group consisting of: i. Heliopropanal, nerol, phenylhexanol, and tetralinol; ii. Anisaldehyde, heliotropin, and terpineol; iii. Anisaldehyde, heliotropin, terpineol, and heliopropanal; iv. Decal, isoeugenol, pericolor, and tetralinol; v. Phenylhexanol, terpineol, and isoeugenol; vi. Phenylhexanol, terpineol, isoeugenol, and coumarin; vii. Eugenol F, phenylhexanol, and carbinol lily; and viii. Eugenol F, phenylhexanol, carbinol muguet, and benzyl acetate, wherein these perfume ingredients are present in the composition in an amount sufficient to provide an antimicrobial effect.

[0051] In some embodiments, the individual components themselves have antimicrobial activity; however, the amount sufficient to provide an antimicrobial effect for the individual components when combined in a composition is less than the amount sufficient to provide an antimicrobial effect for a given individual component used separately.

[0052] In some embodiments, an amount sufficient to provide antimicrobial benefit does not affect the overall odor profile of the composition.

[0053] In some aspects, the compositions of the present disclosure, or their use, allow for the amount of other bioactive ingredients, such as triclosan, to be reduced without affecting the overall fragrance profile, due to the antimicrobial effectiveness of the composition being achieved at lower dosages.

[0054] In some aspects, the present disclosure provides uses, or methods of using, compositions comprising a fragrance ingredient, the composition being selected from the group consisting of: i. Heliopropanal, nerol, phenylhexanol, and tetralinol; ii. Anisaldehyde, heliotropin, and terpineol; iii. Anisaldehyde, heliotropin, terpineol, and heliopropanal; iv. Decal, isoeugenol, pericolor, and tetralinol; v. Phenylhexanol, terpineol, and isoeugenol; vi. Phenylhexanol, terpineol, isoeugenol, and coumarin; vii. Eugenol F, phenylhexanol, and carbinol lily; and viii. Eugenol F, phenylhexanol, carbinol muguet, and benzyl acetate, wherein these perfume ingredients are present in the composition in an amount sufficient to provide an antimicrobial effect.

[0055] In some embodiments, the compositions provide an antibacterial effect by inactivating bacterial cells, hi one embodiment, the bacterial cells comprise a bacterial strain selected from the group consisting of Corynebacterium xerosis, Pseudomonas aeruginosa, Salmonella enterica, Staphylococcus haemolyticus, Staphylococcus aureus, and Escherichia coli.

[0056] In some aspects, the present invention provides methods comprising treating a substrate containing microorganisms with an effective amount of a composition according to some aspects of the present disclosure to provide an antimicrobial effect.

[0057] "Terpineol" refers to its normal meaning in the art, i.e., α-terpineol, β-terpineol, γ-terpineol, terpinen-4-ol, or mixtures thereof. Alternatively, the terpineol present in the composition is α-terpineol or terpinen-4-ol. Alternatively, the terpineol present in the composition is α-terpineol. In some embodiments, the compound has the following structure: [ka]

[0058] The perfume ingredient 4-methoxybenzaldehyde is known as anisaldehyde or as the compound having the following structure: [ka]

[0059] The fragrance ingredient 1,3-benzodioxole-5-carbaldehyde is known as heliotropin or as the compound having the following structure: [ka]

[0060] The perfume ingredient gamma-dodecalactone is known as decal or as the compound having the following structure: [ka]

[0061] The perfume ingredient (Z)-3,7-dimethyl-2,6-octadien-1-ol is known as nerol or as the compound having the following structure: [ka]

[0062] The perfume ingredient 2-methoxy-4-(prop-1-en-1-yl)phenol is known as isoeugenol or as the compound having the following structure: [ka] Eugenol

[0063] The perfume ingredient 2H-chromen-2-one is known as coumarin or as a compound having the following structure: [ka]

[0064] The perfume ingredient 2-methoxy-4-(prop-2-en-1-yl)phenol is known as eugenol F or as the compound having the following structure: [ka]

[0065] The perfume ingredient dimethylphenylethyl carbinol is known as carbinol lily of the valley or as the compound having the following structure: [ka]

[0066] The perfume ingredient (S)-(-)-(4-isopropenyl-1-cyclohexenyl)methanol is known as pericolore or as the compound having the following structure: [ka]

[0067] The perfume ingredient 3-(1,3-benzodioxol-5-yl)-2-methylpropanal is known as heliopropanal or as the compound having the following structure: [ka]

[0068] The perfume ingredient 3-methyl-5-phenyl-1-pentanol is known as phenylhexanol or as the compound having the following structure: [ka]

[0069] The perfume ingredient 3,7-dimethyl-3-octanol is known as tetralinol or as the compound having the following structure: [ka]

[0070] The fragrance ingredient benzyl acetate, or a compound with the following structure: [ka]

[0071] According to any one of the above-described embodiments, the composition is used as an antibacterial agent. A non-limiting list of bacteria against which the composition is particularly effective includes Escherichia coli (ATCC 10536), Corynebacterium xerosis (ATCC 373), Pseudomonas aeruginosa (ATCC 15442), Salmonella enterica (ATCC 10708), Staphylococcus haemolyticus (ATCC 114126), or Staphylococcus aureus (ATCC 6538).

[0072] The term "antimicrobial agent" has its usual meaning in the art, ie, an agent that kills or inhibits the growth of microorganisms.

[0073] In some aspects, the present disclosure provides antimicrobial compositions comprising heliopropanal, nerol, phenylhexanol, and tetralinol.

[0074] Alternatively, in some aspects, the present disclosure provides for the use of an antimicrobial composition comprising heliopropanal, nerol, phenylhexanol, and tetralinol.

[0075] Alternatively, the present disclosure provides a non-therapeutic method of affecting microbial activity, the method comprising treating a substrate containing microorganisms with a composition comprising heliopropanal, nerol, phenylhexanol, and tetralinol, wherein the substrate is treated with an effective amount of the composition to provide an antimicrobial effect.

[0076] In some aspects, the present disclosure provides antimicrobially active consumer products comprising heliopropanal, nerol, phenylhexanol, and tetralinol.

[0077] Alternatively, in some aspects, the present disclosure provides for the use of, or methods of using, an antimicrobial composition comprising heliopropanal, nerol, phenylhexanol, and tetralinol to manufacture an antimicrobially active consumer product.

[0078] In some aspects, the present disclosure provides a non-therapeutic method of affecting microbial activity, the method comprising treating a substrate containing microorganisms with an antimicrobially active consumer product comprising heliopropanal, nerol, phenylhexanol, and tetralinol, wherein the substrate is treated with an effective amount of the composition to provide an antimicrobial effect.

[0079] The phrase "antimicrobially active consumer product" means what is commonly known in the art, i.e., a consumer product that is expected to inhibit the growth of or kill microorganisms present on the surface to which it is applied (e.g., skin, hair, textiles, or residential surfaces).

[0080] In some embodiments, the ratio of fragrance ingredients can provide a synergistic antimicrobial effect, imparting desirable, balanced, and / or appealing hedonic performance. In some embodiments, the ratio of heliopropanal, nerol, phenylhexanol, and tetralinol in the antimicrobial composition is 6:3:5:6. Alternatively, in some embodiments, the ratio of heliopropanal, nerol, phenylhexanol, and tetralinol in the antimicrobial composition is 1:12:5:2. Alternatively, in some embodiments, the ratio of heliopropanal, nerol, phenylhexanol, and tetralinol in the antimicrobial composition is 1:3:5:1. Alternatively, in some embodiments, the ratio of heliopropanal, nerol, phenylhexanol, and tetralinol in the antimicrobial composition is 6:1:1:2. Alternatively, in some embodiments, the ratio of heliopropanal, nerol, phenylhexanol, and tetralinol in the antimicrobial composition is 4:6:7:3.

[0081] In some embodiments, the effective amount of the antimicrobial composition to provide antimicrobial effect is 0.05-0.5% w / v. Alternatively, in some embodiments, the effective amount of the antimicrobial composition to provide antimicrobial effect is 0.05-0.49% w / v. Alternatively, in some embodiments, the effective amount of the antimicrobial composition to provide antimicrobial effect is 0.05-0.48% w / v. Alternatively, in some embodiments, the effective amount of the antimicrobial composition to provide antimicrobial effect is 0.05-0.47% w / v. Alternatively, in some embodiments, the effective amount of the antimicrobial composition to provide antimicrobial effect is 0.05-0.46% w / v. Alternatively, in some embodiments, the effective amount of the antimicrobial composition to provide antimicrobial effect is 0.05-0.45% w / v. Alternatively, in some embodiments, the effective amount of the antimicrobial composition to provide antimicrobial effect is 0.05-0.44% w / v. Alternatively, in some embodiments, the effective amount of the antimicrobial composition to provide antimicrobial effect is 0.05 to 0.43% w / v. Alternatively, in some embodiments, the effective amount of the antimicrobial composition to provide antimicrobial effect is 0.05 to 0.42% w / v. Alternatively, in some embodiments, the effective amount of the antimicrobial composition to provide antimicrobial effect is 0.05 to 0.41% w / v. Alternatively, in some embodiments, the effective amount of the antimicrobial composition to provide antimicrobial effect is 0.05 to 0.4% w / v. Alternatively, in some embodiments, the effective amount of the antimicrobial composition to provide antimicrobial effect is 0.05 to 0.39% w / v. Alternatively, in some embodiments, the effective amount of the antimicrobial composition to provide antimicrobial effect is 0.05 to 0.38% w / v. Alternatively, in some embodiments, the effective amount of the antimicrobial composition to provide antimicrobial effect is 0.05 to 0.37% w / v. Alternatively, in some embodiments, the effective amount of the antimicrobial composition to provide antimicrobial benefit is 0.05-0.36% w / v. Alternatively, in some embodiments, the effective amount of the antimicrobial composition to provide antimicrobial benefit is 0.05-0.35% w / v. Alternatively, in some embodiments, the effective amount of the antimicrobial composition to provide antimicrobial benefit is 0.05-0.34% w / v. Alternatively, in some embodiments, the effective amount of the antimicrobial composition to provide antimicrobial benefit is 0.05-0.33% w / v.Alternatively, in some embodiments, the effective amount of the antimicrobial composition to provide antimicrobial effect is 0.05-0.32% w / v. Alternatively, in some embodiments, the effective amount of the antimicrobial composition to provide antimicrobial effect is 0.05-0.31% w / v. Alternatively, in some embodiments, the effective amount of the antimicrobial composition to provide antimicrobial effect is 0.05-0.3% w / v. Alternatively, in some embodiments, the effective amount of the antimicrobial composition to provide antimicrobial effect is 0.05-0.29% w / v. Alternatively, in some embodiments, the effective amount of the antimicrobial composition to provide antimicrobial effect is 0.05-0.28% w / v. Alternatively, in some embodiments, the effective amount of the antimicrobial composition to provide antimicrobial effect is 0.05-0.27% w / v. Alternatively, in some embodiments, the effective amount of the antimicrobial composition to provide antimicrobial effect is 0.05-0.26% w / v. Alternatively, in some embodiments, the effective amount of the antimicrobial composition to provide antimicrobial effect is 0.05-0.25% w / v. Alternatively, in some embodiments, the effective amount of the antimicrobial composition to provide antimicrobial effect is 0.05-0.24% w / v. Alternatively, in some embodiments, the effective amount of the antimicrobial composition to provide antimicrobial effect is 0.05-0.23% w / v. Alternatively, in some embodiments, the effective amount of the antimicrobial composition to provide antimicrobial effect is 0.05-0.22% w / v. Alternatively, in some embodiments, the effective amount of the antimicrobial composition to provide antimicrobial effect is 0.05-0.21% w / v. Alternatively, in some embodiments, the effective amount of the antimicrobial composition to provide antimicrobial effect is 0.05-0.2% w / v. Alternatively, in some embodiments, the effective amount of the antimicrobial composition to provide antimicrobial effect is 0.05-0.19% w / v. Alternatively, in some embodiments, the effective amount of the antimicrobial composition to provide antimicrobial benefit is 0.05-0.18% w / v. Alternatively, in some embodiments, the effective amount of the antimicrobial composition to provide antimicrobial benefit is 0.05-0.17% w / v. Alternatively, in some embodiments, the effective amount of the antimicrobial composition to provide antimicrobial benefit is 0.05-0.16% w / v. Alternatively, in some embodiments, the effective amount of the antimicrobial composition to provide antimicrobial benefit is 0.05-0.15% w / v.Alternatively, in some embodiments, the effective amount of the antimicrobial composition to provide antimicrobial effect is 0.05-0.14% w / v. Alternatively, in some embodiments, the effective amount of the antimicrobial composition to provide antimicrobial effect is 0.05-0.13% w / v. Alternatively, in some embodiments, the effective amount of the antimicrobial composition to provide antimicrobial effect is 0.05-0.12% w / v. Alternatively, in some embodiments, the effective amount of the antimicrobial composition to provide antimicrobial effect is 0.05-0.11% w / v. Alternatively, in some embodiments, the effective amount of the antimicrobial composition to provide antimicrobial effect is 0.05-0.1% w / v. Alternatively, in some embodiments, the effective amount of the antimicrobial composition to provide antimicrobial effect is 0.05-0.09% w / v. Alternatively, in some embodiments, the effective amount of the antimicrobial composition to provide antimicrobial effect is 0.05-0.08% w / v. Alternatively, in some embodiments, the effective amount of the antimicrobial composition to provide antimicrobial benefit is 0.05-0.07% w / v, or 0.05-0.06% w / v.

[0082] Alternatively, in some embodiments, the effective amount of the antimicrobial composition to provide antimicrobial effect is 0.06-0.5% w / v. Alternatively, in some embodiments, the effective amount of the antimicrobial composition to provide antimicrobial effect is 0.07-0.5% w / v. Alternatively, in some embodiments, the effective amount of the antimicrobial composition to provide antimicrobial effect is 0.08-0.5% w / v. Alternatively, in some embodiments, the effective amount of the antimicrobial composition to provide antimicrobial effect is 0.09-0.5% w / v. Alternatively, in some embodiments, the effective amount of the antimicrobial composition to provide antimicrobial effect is 0.1-0.5% w / v. Alternatively, in some embodiments, the effective amount of the antimicrobial composition to provide antimicrobial effect is 0.11-0.5% w / v. Alternatively, in some embodiments, the effective amount of the antimicrobial composition to provide antimicrobial effect is 0.12-0.5% w / v. Alternatively, in some embodiments, the effective amount of the antimicrobial composition to provide antimicrobial effect is 0.13-0.5% w / v. Alternatively, in some embodiments, the effective amount of the antimicrobial composition to provide antimicrobial effect is 0.14-0.5% w / v. Alternatively, in some embodiments, the effective amount of the antimicrobial composition to provide antimicrobial effect is 0.15-0.5% w / v. Alternatively, in some embodiments, the effective amount of the antimicrobial composition to provide antimicrobial effect is 0.16-0.5% w / v. Alternatively, in some embodiments, the effective amount of the antimicrobial composition to provide antimicrobial effect is 0.17-0.5% w / v. Alternatively, in some embodiments, the effective amount of the antimicrobial composition to provide antimicrobial effect is 0.18-0.5% w / v. Alternatively, in some embodiments, the effective amount of the antimicrobial composition to provide antimicrobial effect is 0.19-0.5% w / v. Alternatively, in some embodiments, the effective amount of the antimicrobial composition to provide antimicrobial benefit is 0.19-0.5% w / v. Alternatively, in some embodiments, the effective amount of the antimicrobial composition to provide antimicrobial benefit is 0.20-0.5% w / v. Alternatively, in some embodiments, the effective amount of the antimicrobial composition to provide antimicrobial benefit is 0.21-0.5% w / v. Alternatively, in some embodiments, the effective amount of the antimicrobial composition to provide antimicrobial benefit is 0.22-0.5% w / v.Alternatively, in some embodiments, the effective amount of the antimicrobial composition to provide antimicrobial effect is 0.23-0.5% w / v. Alternatively, in some embodiments, the effective amount of the antimicrobial composition to provide antimicrobial effect is 0.24-0.5% w / v. Alternatively, in some embodiments, the effective amount of the antimicrobial composition to provide antimicrobial effect is 0.25-0.5% w / v. Alternatively, in some embodiments, the effective amount of the antimicrobial composition to provide antimicrobial effect is 0.26-0.5% w / v. Alternatively, in some embodiments, the effective amount of the antimicrobial composition to provide antimicrobial effect is 0.27-0.5% w / v. Alternatively, in some embodiments, the effective amount of the antimicrobial composition to provide antimicrobial effect is 0.28-0.5% w / v. Alternatively, in some embodiments, the effective amount of the antimicrobial composition to provide antimicrobial effect is 0.29-0.5% w / v. Alternatively, in some embodiments, the effective amount of the antimicrobial composition to provide antimicrobial effect is 0.30-0.5% w / v. Alternatively, in some embodiments, the effective amount of the antimicrobial composition to provide antimicrobial effect is 0.31-0.5% w / v. Alternatively, in some embodiments, the effective amount of the antimicrobial composition to provide antimicrobial effect is 0.32-0.5% w / v. Alternatively, in some embodiments, the effective amount of the antimicrobial composition to provide antimicrobial effect is 0.33-0.5% w / v. Alternatively, in some embodiments, the effective amount of the antimicrobial composition to provide antimicrobial effect is 0.34-0.5% w / v. Alternatively, in some embodiments, the effective amount of the antimicrobial composition to provide antimicrobial effect is 0.35-0.5% w / v. Alternatively, in some embodiments, the effective amount of the antimicrobial composition to provide antimicrobial effect is 0.36-0.5% w / v. Alternatively, in some embodiments, the effective amount of the antimicrobial composition to provide antimicrobial benefit is 0.37-0.5% w / v. Alternatively, in some embodiments, the effective amount of the antimicrobial composition to provide antimicrobial benefit is 0.38-0.5% w / v. Alternatively, in some embodiments, the effective amount of the antimicrobial composition to provide antimicrobial benefit is 0.39-0.5% w / v. Alternatively, in some embodiments, the effective amount of the antimicrobial composition to provide antimicrobial benefit is 0.40-0.5% w / v.Alternatively, in some embodiments, the effective amount of the antimicrobial composition to provide antimicrobial effect is 0.41-0.5% w / v. Alternatively, in some embodiments, the effective amount of the antimicrobial composition to provide antimicrobial effect is 0.42-0.5% w / v. Alternatively, in some embodiments, the effective amount of the antimicrobial composition to provide antimicrobial effect is 0.43-0.5% w / v. Alternatively, in some embodiments, the effective amount of the antimicrobial composition to provide antimicrobial effect is 0.44-0.5% w / v. Alternatively, in some embodiments, the effective amount of the antimicrobial composition to provide antimicrobial effect is 0.45-0.5% w / v. Alternatively, in some embodiments, the effective amount of the antimicrobial composition to provide antimicrobial effect is 0.46-0.5% w / v. Alternatively, in some embodiments, the effective amount of the antimicrobial composition to provide antimicrobial effect is 0.47-0.5% w / v. Alternatively, in some embodiments, the effective amount of the antimicrobial composition to provide antimicrobial benefit is 0.48-0.5% w / v, or 0.49-0.5% w / v.

[0083] In some embodiments, the effective amount of the antimicrobial composition to provide an antimicrobial effect is 0.05, or 0.06, or 0.07, or 0.08, or 0.08, or 0.1, or 0.11, or 0.12, or 0.13, or 0.14, or 0.15, or 0.16, or 0.17, or 0.18, or 0.19, or 0.2, or 0.21, or 0.22, or 0.23, or 0.24, or 0.25, or 0. 0.26, or 0.27, or 0.28, or 0.29, or 0.3, or 0.31, or 0.32, or 0.33, or 0.34, or 0.35, or 0.36, or 0.37, or 0.38, or 0.39, or 0.4, or 0.41, or 0.42, or 0.43, or 0.44, or 0.45, or 0.46, or 0.47, or 0.48, or 0.49, or 0.5% w / v.

[0084] In some aspects, the present disclosure provides an antimicrobial composition comprising anisaldehyde, heliotropin, and terpineol.

[0085] Alternatively, in some aspects, the present disclosure provides for the use of an antimicrobial composition comprising anisaldehyde, heliotropin, and terpineol.

[0086] Alternatively, the present disclosure provides a non-therapeutic method of affecting microbial activity, the method comprising treating a substrate containing microorganisms with a composition comprising anisaldehyde, heliotropin, and terpineol, wherein the substrate is treated with an effective amount of the composition to provide an antimicrobial effect.

[0087] In some aspects, the present disclosure provides antimicrobially active consumer products comprising anisaldehyde, heliotropin, and terpineol.

[0088] Alternatively, in some aspects, the present disclosure provides for the use of, or methods of using, an antimicrobial composition comprising anisaldehyde, heliotropin, and terpineol to make an antimicrobially active consumer product.

[0089] In some aspects, the present disclosure provides a non-therapeutic method of affecting microbial activity, the method comprising treating a substrate containing microorganisms with an antimicrobially active consumer product comprising anisaldehyde, heliotropin, and terpineol, wherein the substrate is treated with an effective amount of the composition to provide an antimicrobial effect.

[0090] In some embodiments, the ratio of fragrance ingredients can provide a synergistic antimicrobial effect and impart desirable, balanced, and / or appealing hedonic performance. In some embodiments, the ratio of anisaldehyde, heliotropin, and terpineol is 13:20:3. Alternatively, in some embodiments, the ratio of anisaldehyde, heliotropin, and terpineol is 1:2:7. Alternatively, in some embodiments, the ratio of anisaldehyde, heliotropin, and terpineol is 5:8:7. Alternatively, in some embodiments, the ratio of anisaldehyde, heliotropin, and terpineol is 8:1:9. Alternatively, in some embodiments, the ratio of anisaldehyde, heliotropin, and terpineol is 1:6:13.

[0091] In some embodiments, the effective amount of the composition to provide antimicrobial benefit is 0.3-0.6% w / v, or 0.4-0.6% w / v, or 0.5-0.6% w / v.

[0092] Alternatively, in some embodiments, the effective amount of the composition to provide antimicrobial benefit is 0.3-0.5% w / v, or 0.3-0.4% w / v.

[0093] In some embodiments, the effective amount of the antimicrobial composition to provide an antimicrobial effect is 0.3, or 0.4, or 0.5, or 0.6% w / v.

[0094] In some aspects, the present disclosure provides antimicrobial compositions comprising anisaldehyde, heliotropin, terpineol, and heliopropanal.

[0095] Alternatively, in some aspects, the present disclosure provides for the use of an antimicrobial composition comprising anisaldehyde, heliotropin, terpineol, and heliopropanal.

[0096] Alternatively, the present disclosure provides a non-therapeutic method of affecting microbial activity, the method comprising treating a substrate containing microorganisms with a composition comprising anisaldehyde, heliotropin, terpineol, and heliopropanal, wherein the substrate is treated with an effective amount of the composition to provide an antimicrobial effect.

[0097] In some aspects, the present disclosure provides antimicrobially active consumer products comprising anisaldehyde, heliotropin, terpineol, and heliopropanal.

[0098] Alternatively, in some aspects, the present disclosure provides a use or method of using an antimicrobial composition comprising anisaldehyde, heliotropin, terpineol, and heliopropanal to make an antimicrobially active consumer product.

[0099] In some aspects, the present disclosure provides a non-therapeutic method of affecting microbial activity, the method comprising treating a substrate containing microorganisms with an antimicrobially active consumer product comprising anisaldehyde, heliotropin, terpineol, and heliopropanal, wherein the substrate is treated with an effective amount of the composition to provide an antimicrobial effect.

[0100] In some embodiments, the ratio of fragrance ingredients can provide a synergistic antimicrobial effect and impart desirable, balanced, and / or appealing hedonic performance. In some embodiments, the ratio of anisaldehyde, heliotropin, terpineol, and heliopropanal is 13:20:3:20. Alternatively, in some embodiments, the ratio of anisaldehyde, heliotropin, terpineol, and heliopropanal is 3:1:3:3. Alternatively, in some embodiments, the ratio of anisaldehyde, heliotropin, terpineol, and heliopropanal is 3:4:10:3. Alternatively, in some embodiments, the ratio of anisaldehyde, heliotropin, terpineol, and heliopropanal is 8:4:5:3. Alternatively, in some embodiments, the ratio of anisaldehyde, heliotropin, terpineol, and heliopropanal is 2:4:13:1.

[0101] In some embodiments, the effective amount of the composition to provide antimicrobial benefit is 0.2-0.5% w / v, alternatively, in some embodiments, the effective amount of the composition to provide antimicrobial benefit is 0.2-0.4% w / v, alternatively, in some embodiments, the effective amount of the composition to provide antimicrobial benefit is 0.2-0.3% w / v.

[0102] In some embodiments, the effective amount of the composition to provide antimicrobial benefit is 0.3-0.5% w / v, or alternatively, in some embodiments, the effective amount of the composition to provide antimicrobial benefit is 0.3-0.4% w / v.

[0103] In some embodiments, the effective amount of the antimicrobial composition to provide an antimicrobial effect is 0.2, or 0.3, or 0.4, or 0.5% w / v.

[0104] In some aspects, the present disclosure provides an antimicrobial composition comprising decal, isoeugenol, pericolor, and tetralinol.

[0105] In some aspects, the present disclosure provides an antimicrobial composition comprising decal, isoeugenol, pericolor, and tetralinol.

[0106] Alternatively, in some aspects, the present disclosure provides for the use of an antimicrobial composition comprising decal, isoeugenol, pericolor, and tetralinol.

[0107] Alternatively, the present disclosure provides a non-therapeutic method of affecting microbial activity, the method comprising treating a substrate containing microorganisms with a composition comprising decal, isoeugenol, pericolor, and tetralinol, wherein the substrate is treated with an effective amount of the composition to provide an antimicrobial effect.

[0108] In some aspects, the present disclosure provides antimicrobially active consumer products comprising decal, isoeugenol, pericolor, and tetralinol.

[0109] Alternatively, in some aspects, the present disclosure provides for the use of, or methods of using, an antimicrobial composition comprising decal, isoeugenol, pellicorole, and tetralinol to make an antimicrobially active consumer product.

[0110] In some aspects, the present disclosure provides a non-therapeutic method of affecting microbial activity, the method comprising treating a substrate containing microorganisms with an antimicrobially active consumer product comprising decal, isoeugenol, pericolor, and tetralinol, wherein the substrate is treated with an effective amount of the composition to provide an antimicrobial effect.

[0111] In some embodiments, the ratio of perfume ingredients can provide a synergistic antimicrobial effect and impart a desirable, balanced, and / or appealing hedonic performance. In some embodiments, the ratio of Decal, isoeugenol, pericolore, and tetralinol is 2:1:5:2. Alternatively, in some embodiments, the ratio of Decal, isoeugenol, pericolore, and tetralinol is 2:2:1:5. Alternatively, in some embodiments, the ratio of Decal, isoeugenol, pericolore, and tetralinol is 4:2:2:2. Alternatively, in some embodiments, the ratio of Decal, isoeugenol, pericolore, and tetralinol is 1:7:4:8. Alternatively, in some embodiments, the ratio of Decal, isoeugenol, pericolore, and tetralinol is 1:3:3:3.

[0112] In some embodiments, the effective amount of the composition to provide antimicrobial effect is 0.05-0.5% w / v. Alternatively, in some embodiments, the effective amount of the composition to provide antimicrobial effect is 0.06-0.5% w / v. Alternatively, in some embodiments, the effective amount of the composition to provide antimicrobial effect is 0.07-0.5% w / v. Alternatively, in some embodiments, the effective amount of the composition to provide antimicrobial effect is 0.08-0.5% w / v. Alternatively, in some embodiments, the effective amount of the composition to provide antimicrobial effect is 0.09-0.5% w / v. Alternatively, in some embodiments, the effective amount of the composition to provide antimicrobial effect is 0.10-0.5% w / v. Alternatively, in some embodiments, the effective amount of the composition to provide antimicrobial effect is 0.11-0.5% w / v. Alternatively, in some embodiments, the effective amount of the composition to provide antimicrobial effect is 0.12-0.5% w / v. Alternatively, in some embodiments, the effective amount of the composition to provide antimicrobial effect is 0.13 to 0.5% w / v. Alternatively, in some embodiments, the effective amount of the composition to provide antimicrobial effect is 0.14 to 0.5% w / v. Alternatively, in some embodiments, the effective amount of the composition to provide antimicrobial effect is 0.15 to 0.5% w / v. Alternatively, in some embodiments, the effective amount of the composition to provide antimicrobial effect is 0.16 to 0.5% w / v. Alternatively, in some embodiments, the effective amount of the composition to provide antimicrobial effect is 0.17 to 0.5% w / v. Alternatively, in some embodiments, the effective amount of the composition to provide antimicrobial effect is 0.18 to 0.5% w / v. Alternatively, in some embodiments, the effective amount of the composition to provide antimicrobial effect is 0.19 to 0.5% w / v. Alternatively, in some embodiments, the effective amount of the composition to provide antimicrobial effect is 0.20 to 0.5% w / v. Alternatively, in some embodiments, the effective amount of the composition to provide antimicrobial benefit is 0.21-0.5% w / v. Alternatively, in some embodiments, the effective amount of the composition to provide antimicrobial benefit is 0.22-0.5% w / v. Alternatively, in some embodiments, the effective amount of the composition to provide antimicrobial benefit is 0.23-0.5% w / v.Alternatively, in some embodiments, the effective amount of the composition to provide antimicrobial effect is 0.24 to 0.5% w / v. Alternatively, in some embodiments, the effective amount of the composition to provide antimicrobial effect is 0.25 to 0.5% w / v. Alternatively, in some embodiments, the effective amount of the composition to provide antimicrobial effect is 0.26 to 0.5% w / v. Alternatively, in some embodiments, the effective amount of the composition to provide antimicrobial effect is 0.27 to 0.5% w / v. Alternatively, in some embodiments, the effective amount of the composition to provide antimicrobial effect is 0.28 to 0.5% w / v. Alternatively, in some embodiments, the effective amount of the composition to provide antimicrobial effect is 0.29 to 0.5% w / v. Alternatively, in some embodiments, the effective amount of the composition to provide antimicrobial effect is 0.30 to 0.5% w / v. Alternatively, in some embodiments, the effective amount of the composition to provide antimicrobial effect is 0.31 to 0.5% w / v. Alternatively, in some embodiments, the effective amount of the composition to provide antimicrobial effect is 0.32 to 0.5% w / v. Alternatively, in some embodiments, the effective amount of the composition to provide antimicrobial effect is 0.33 to 0.5% w / v. Alternatively, in some embodiments, the effective amount of the composition to provide antimicrobial effect is 0.34 to 0.5% w / v. Alternatively, in some embodiments, the effective amount of the composition to provide antimicrobial effect is 0.35 to 0.5% w / v. Alternatively, in some embodiments, the effective amount of the composition to provide antimicrobial effect is 0.36 to 0.5% w / v. Alternatively, in some embodiments, the effective amount of the composition to provide antimicrobial effect is 0.37 to 0.5% w / v. Alternatively, in some embodiments, the effective amount of the composition to provide antimicrobial effect is 0.38 to 0.5% w / v. Alternatively, in some embodiments, the effective amount of the composition to provide antimicrobial effect is 0.39 to 0.5% w / v. Alternatively, in some embodiments, the effective amount of the composition to provide antimicrobial benefit is 0.40-0.5% w / v. Alternatively, in some embodiments, the effective amount of the composition to provide antimicrobial benefit is 0.41-0.5% w / v. Alternatively, in some embodiments, the effective amount of the composition to provide antimicrobial benefit is 0.42-0.5% w / v.Alternatively, in some embodiments, the effective amount of the composition to provide antimicrobial effect is 0.43 to 0.5% w / v. Alternatively, in some embodiments, the effective amount of the composition to provide antimicrobial effect is 0.44 to 0.5% w / v. Alternatively, in some embodiments, the effective amount of the composition to provide antimicrobial effect is 0.45 to 0.5% w / v. Alternatively, in some embodiments, the effective amount of the composition to provide antimicrobial effect is 0.46 to 0.5% w / v. Alternatively, in some embodiments, the effective amount of the composition to provide antimicrobial effect is 0.47 to 0.5% w / v. Alternatively, in some embodiments, the effective amount of the composition to provide antimicrobial effect is 0.48 to 0.5% w / v. Alternatively, in some embodiments, the effective amount of the composition to provide antimicrobial effect is 0.49 to 0.5% w / v.

[0113] Alternatively, in some embodiments, the effective amount of the composition for providing antimicrobial effect is 0.05 to 0.49% w / v. Alternatively, in some embodiments, the effective amount of the composition for providing antimicrobial effect is 0.05 to 0.48% w / v. Alternatively, in some embodiments, the effective amount of the composition for providing antimicrobial effect is 0.05 to 0.47% w / v. Alternatively, in some embodiments, the effective amount of the composition for providing antimicrobial effect is 0.05 to 0.46% w / v. Alternatively, in some embodiments, the effective amount of the composition for providing antimicrobial effect is 0.05 to 0.45% w / v. Alternatively, in some embodiments, the effective amount of the composition for providing antimicrobial effect is 0.02 to 0.44% w / v. Alternatively, in some embodiments, the effective amount of the composition for providing antimicrobial effect is 0.05 to 0.43% w / v. Alternatively, in some embodiments, the effective amount of the composition for providing antimicrobial effect is 0.05 to 0.42% w / v. Alternatively, in some embodiments, the effective amount of the composition for providing antimicrobial effect is 0.05 to 0.41% w / v. Alternatively, in some embodiments, the effective amount of the composition for providing antimicrobial effect is 0.05 to 0.40% w / v. Alternatively, in some embodiments, the effective amount of the composition for providing antimicrobial effect is 0.05 to 0.39% w / v. Alternatively, in some embodiments, the effective amount of the composition for providing antimicrobial effect is 0.05 to 0.38% w / v. Alternatively, in some embodiments, the effective amount of the composition for providing antimicrobial effect is 0.05 to 0.37% w / v. Alternatively, in some embodiments, the effective amount of the composition for providing antimicrobial effect is 0.05 to 0.36% w / v. Alternatively, in some embodiments, the effective amount of the composition to provide antimicrobial benefit is 0.05-0.35% w / v. Alternatively, in some embodiments, the effective amount of the composition to provide antimicrobial benefit is 0.02-0.34% w / v. Alternatively, in some embodiments, the effective amount of the composition to provide antimicrobial benefit is 0.05-0.33% w / v. Alternatively, in some embodiments, the effective amount of the composition to provide antimicrobial benefit is 0.05-0.32% w / v.Alternatively, in some embodiments, the effective amount of the composition for providing antimicrobial effect is 0.05 to 0.31% w / v. Alternatively, in some embodiments, the effective amount of the composition for providing antimicrobial effect is 0.05 to 0.30% w / v. Alternatively, in some embodiments, the effective amount of the composition for providing antimicrobial effect is 0.05 to 0.29% w / v. Alternatively, in some embodiments, the effective amount of the composition for providing antimicrobial effect is 0.05 to 0.28% w / v. Alternatively, in some embodiments, the effective amount of the composition for providing antimicrobial effect is 0.05 to 0.27% w / v. Alternatively, in some embodiments, the effective amount of the composition for providing antimicrobial effect is 0.05 to 0.26% w / v. Alternatively, in some embodiments, the effective amount of the composition for providing antimicrobial effect is 0.05 to 0.25% w / v. Alternatively, in some embodiments, the effective amount of the composition to provide antimicrobial effect is 0.05 to 0.24% w / v. Alternatively, in some embodiments, the effective amount of the composition to provide antimicrobial effect is 0.05 to 0.23% w / v. Alternatively, in some embodiments, the effective amount of the composition to provide antimicrobial effect is 0.05 to 0.22% w / v. Alternatively, in some embodiments, the effective amount of the composition to provide antimicrobial effect is 0.05 to 0.21% w / v. Alternatively, in some embodiments, the effective amount of the composition to provide antimicrobial effect is 0.05 to 0.20% w / v. Alternatively, in some embodiments, the effective amount of the composition to provide antimicrobial effect is 0.05 to 0.19% w / v. Alternatively, in some embodiments, the effective amount of the composition to provide antimicrobial effect is 0.05 to 0.18% w / v. Alternatively, in some embodiments, the effective amount of the composition to provide antimicrobial benefit is 0.05-0.17% w / v. Alternatively, in some embodiments, the effective amount of the composition to provide antimicrobial benefit is 0.05-0.16% w / v. Alternatively, in some embodiments, the effective amount of the composition to provide antimicrobial benefit is 0.05-0.15% w / v. Alternatively, in some embodiments, the effective amount of the composition to provide antimicrobial benefit is 0.02-0.14% w / v.Alternatively, in some embodiments, the effective amount of the composition for providing antimicrobial effect is 0.05-0.13% w / v. Alternatively, in some embodiments, the effective amount of the composition for providing antimicrobial effect is 0.05-0.12% w / v. Alternatively, in some embodiments, the effective amount of the composition for providing antimicrobial effect is 0.05-0.11% w / v. Alternatively, in some embodiments, the effective amount of the composition for providing antimicrobial effect is 0.05-0.10% w / v. Alternatively, in some embodiments, the effective amount of the composition for providing antimicrobial effect is 0.05-0.09% w / v. Alternatively, in some embodiments, the effective amount of the composition for providing antimicrobial effect is 0.05-0.08% w / v. Alternatively, in some embodiments, the effective amount of the composition for providing antimicrobial effect is 0.05-0.07% w / v. Alternatively, in some embodiments, the effective amount of the composition to provide antimicrobial benefit is 0.05-0.06% w / v.

[0114] In some embodiments, the effective amount of the antimicrobial composition to provide an antimicrobial effect is 0.05, or 0.06, or 0.07, or 0.08, or 0.08, or 0.1, or 0.11, or 0.12, or 0.13, or 0.14, or 0.15, or 0.16, or 0.17, or 0.18, or 0.09, or 0.2, or 0.21, or 0.22, or 0.23, or 0.24, or 0.25, or 0. 0.26, or 0.27, or 0.28, or 0.29, or 0.3, or 0.31, or 0.32, or 0.33, or 0.34, or 0.35, or 0.36, or 0.37, or 0.38, or 0.39, or 0.4, or 0.41, or 0.42, or 0.43, or 0.44, or 0.45, or 0.46, or 0.47, or 0.48, or 0.49, or 0.5% w / v.

[0115] In some aspects, the present disclosure provides antimicrobial compositions comprising phenylhexanol, terpineol, and isoeugenol.

[0116] Alternatively, in some aspects, the present disclosure provides for the use of an antimicrobial composition comprising phenylhexanol, terpineol, and isoeugenol.

[0117] Alternatively, the present disclosure provides a non-therapeutic method of affecting microbial activity, the method comprising treating a substrate containing microorganisms with a composition comprising phenylhexanol, terpineol, and isoeugenol, wherein the substrate is treated with an effective amount of the composition to provide an antimicrobial effect.

[0118] In some aspects, the present disclosure provides antimicrobially active consumer products comprising phenylhexanol, terpineol, and isoeugenol.

[0119] Alternatively, in some aspects, the present disclosure provides for the use of, or methods of using, an antimicrobial composition comprising phenylhexanol, terpineol, and isoeugenol to make an antimicrobially active consumer product.

[0120] In some aspects, the disclosure provides a non-therapeutic method of affecting microbial activity, the method comprising treating a substrate containing microorganisms with an antimicrobially active consumer product comprising phenylhexanol, terpineol, and isoeugenol, wherein the substrate is treated with an effective amount of the composition to provide an antimicrobial effect.

[0121] In some embodiments, the ratio of fragrance ingredients can provide a synergistic antimicrobial effect and impart a desirable, balanced, and / or appealing hedonic performance. In some embodiments, the ratio of phenylhexanol, terpineol, and isoeugenol is 2:5:5. Alternatively, in some embodiments, the ratio of phenylhexanol, terpineol, and isoeugenol is 1:14:5. Alternatively, in some embodiments, the ratio of phenylhexanol, terpineol, and isoeugenol is 2:1:7. Alternatively, in some embodiments, the ratio of phenylhexanol, terpineol, and isoeugenol is 8:9:3. Alternatively, in some embodiments, the ratio of phenylhexanol, terpineol, and isoeugenol is 12:7:1.

[0122] In some embodiments, the effective amount of the composition to provide antimicrobial benefit is 0.06-0.5% w / v. Alternatively, in some embodiments, the effective amount of the composition to provide antimicrobial benefit is 0.07-0.5% w / v. Alternatively, in some embodiments, the effective amount of the composition to provide antimicrobial benefit is 0.08-0.5% w / v. Alternatively, in some embodiments, the effective amount of the composition to provide antimicrobial benefit is 0.09-0.5% w / v. Alternatively, in some embodiments, the effective amount of the composition to provide antimicrobial benefit is 0.10-0.5% w / v. Alternatively, in some embodiments, the effective amount of the composition to provide antimicrobial benefit is 0.11-0.5% w / v. Alternatively, in some embodiments, the effective amount of the composition to provide antimicrobial benefit is 0.12-0.5% w / v. Alternatively, in some embodiments, the effective amount of the composition to provide antimicrobial benefit is 0.13-0.5% w / v. Alternatively, in some embodiments, the effective amount of the composition to provide antimicrobial effect is 0.14 to 0.5% w / v. Alternatively, in some embodiments, the effective amount of the composition to provide antimicrobial effect is 0.15 to 0.5% w / v. Alternatively, in some embodiments, the effective amount of the composition to provide antimicrobial effect is 0.16 to 0.5% w / v. Alternatively, in some embodiments, the effective amount of the composition to provide antimicrobial effect is 0.17 to 0.5% w / v. Alternatively, in some embodiments, the effective amount of the composition to provide antimicrobial effect is 0.18 to 0.5% w / v. Alternatively, in some embodiments, the effective amount of the composition to provide antimicrobial effect is 0.19 to 0.5% w / v. Alternatively, in some embodiments, the effective amount of the composition to provide antimicrobial effect is 0.20 to 0.5% w / v. Alternatively, in some embodiments, the effective amount of the composition to provide antimicrobial effect is 0.21 to 0.5% w / v. Alternatively, in some embodiments, the effective amount of the composition to provide antimicrobial benefit is 0.22-0.5% w / v. Alternatively, in some embodiments, the effective amount of the composition to provide antimicrobial benefit is 0.23-0.5% w / v. Alternatively, in some embodiments, the effective amount of the composition to provide antimicrobial benefit is 0.24-0.5% w / v.Alternatively, in some embodiments, the effective amount of the composition to provide antimicrobial effect is 0.25-0.5% w / v. Alternatively, in some embodiments, the effective amount of the composition to provide antimicrobial effect is 0.26-0.5% w / v. Alternatively, in some embodiments, the effective amount of the composition to provide antimicrobial effect is 0.27-0.5% w / v. Alternatively, in some embodiments, the effective amount of the composition to provide antimicrobial effect is 0.28-0.5% w / v. Alternatively, in some embodiments, the effective amount of the composition to provide antimicrobial effect is 0.29-0.5% w / v. Alternatively, in some embodiments, the effective amount of the composition to provide antimicrobial effect is 0.30-0.5% w / v. Alternatively, in some embodiments, the effective amount of the composition to provide antimicrobial effect is 0.31-0.5% w / v. Alternatively, in some embodiments, the effective amount of the composition to provide antimicrobial effect is 0.32-0.5% w / v. Alternatively, in some embodiments, the effective amount of the composition to provide antimicrobial effect is 0.33 to 0.5% w / v. Alternatively, in some embodiments, the effective amount of the composition to provide antimicrobial effect is 0.34 to 0.5% w / v. Alternatively, in some embodiments, the effective amount of the composition to provide antimicrobial effect is 0.35 to 0.5% w / v. Alternatively, in some embodiments, the effective amount of the composition to provide antimicrobial effect is 0.36 to 0.5% w / v. Alternatively, in some embodiments, the effective amount of the composition to provide antimicrobial effect is 0.37 to 0.5% w / v. Alternatively, in some embodiments, the effective amount of the composition to provide antimicrobial effect is 0.38 to 0.5% w / v. Alternatively, in some embodiments, the effective amount of the composition to provide antimicrobial effect is 0.39 to 0.5% w / v. Alternatively, in some embodiments, the effective amount of the composition to provide antimicrobial effect is 0.40 to 0.5% w / v. Alternatively, in some embodiments, the effective amount of the composition to provide antimicrobial benefit is 0.41-0.5% w / v. Alternatively, in some embodiments, the effective amount of the composition to provide antimicrobial benefit is 0.42-0.5% w / v. Alternatively, in some embodiments, the effective amount of the composition to provide antimicrobial benefit is 0.43-0.5% w / v.Alternatively, in some embodiments, the effective amount of the composition to provide antimicrobial benefit is 0.44-0.5% w / v. Alternatively, in some embodiments, the effective amount of the composition to provide antimicrobial benefit is 0.45-0.5% w / v. Alternatively, in some embodiments, the effective amount of the composition to provide antimicrobial benefit is 0.46-0.5% w / v. Alternatively, in some embodiments, the effective amount of the composition to provide antimicrobial benefit is 0.47-0.5% w / v. Alternatively, in some embodiments, the effective amount of the composition to provide antimicrobial benefit is 0.48-0.5% w / v. Alternatively, in some embodiments, the effective amount of the composition to provide antimicrobial benefit is 0.49-0.5% w / v.

[0123] Alternatively, in some embodiments, the effective amount of the composition for providing antimicrobial effect is 0.06 to 0.49% w / v. Alternatively, in some embodiments, the effective amount of the composition for providing antimicrobial effect is 0.06 to 0.48% w / v. Alternatively, in some embodiments, the effective amount of the composition for providing antimicrobial effect is 0.06 to 0.47% w / v. Alternatively, in some embodiments, the effective amount of the composition for providing antimicrobial effect is 0.06 to 0.46% w / v. Alternatively, in some embodiments, the effective amount of the composition for providing antimicrobial effect is 0.06 to 0.45% w / v. Alternatively, in some embodiments, the effective amount of the composition for providing antimicrobial effect is 0.06 to 0.44% w / v. Alternatively, in some embodiments, the effective amount of the composition for providing antimicrobial effect is 0.06 to 0.43% w / v. Alternatively, in some embodiments, the effective amount of the composition for providing antimicrobial effect is 0.06 to 0.42% w / v. Alternatively, in some embodiments, the effective amount of the composition for providing antimicrobial effect is 0.06 to 0.41% w / v. Alternatively, in some embodiments, the effective amount of the composition for providing antimicrobial effect is 0.06 to 0.40% w / v. Alternatively, in some embodiments, the effective amount of the composition for providing antimicrobial effect is 0.06 to 0.39% w / v. Alternatively, in some embodiments, the effective amount of the composition for providing antimicrobial effect is 0.06 to 0.38% w / v. Alternatively, in some embodiments, the effective amount of the composition for providing antimicrobial effect is 0.06 to 0.37% w / v. Alternatively, in some embodiments, the effective amount of the composition for providing antimicrobial effect is 0.06 to 0.36% w / v. Alternatively, in some embodiments, the effective amount of the composition to provide antimicrobial benefit is 0.06-0.35% w / v. Alternatively, in some embodiments, the effective amount of the composition to provide antimicrobial benefit is 0.06-0.34% w / v. Alternatively, in some embodiments, the effective amount of the composition to provide antimicrobial benefit is 0.06-0.33% w / v. Alternatively, in some embodiments, the effective amount of the composition to provide antimicrobial benefit is 0.06-0.32% w / v.Alternatively, in some embodiments, the effective amount of the composition to provide antimicrobial effect is 0.06 to 0.31% w / v. Alternatively, in some embodiments, the effective amount of the composition to provide antimicrobial effect is 0.06 to 0.30% w / v. Alternatively, in some embodiments, the effective amount of the composition to provide antimicrobial effect is 0.06 to 0.29% w / v. Alternatively, in some embodiments, the effective amount of the composition to provide antimicrobial effect is 0.06 to 0.28% w / v. Alternatively, in some embodiments, the effective amount of the composition to provide antimicrobial effect is 0.06 to 0.27% w / v. Alternatively, in some embodiments, the effective amount of the composition to provide antimicrobial effect is 0.06 to 0.26% w / v. Alternatively, in some embodiments, the effective amount of the composition to provide antimicrobial effect is 0.06 to 0.25% w / v. Alternatively, in some embodiments, the effective amount of the composition to provide antimicrobial effect is 0.06 to 0.24% w / v. Alternatively, in some embodiments, the effective amount of the composition to provide antimicrobial effect is 0.06 to 0.23% w / v. Alternatively, in some embodiments, the effective amount of the composition to provide antimicrobial effect is 0.06 to 0.22% w / v. Alternatively, in some embodiments, the effective amount of the composition to provide antimicrobial effect is 0.06 to 0.21% w / v. Alternatively, in some embodiments, the effective amount of the composition to provide antimicrobial effect is 0.06 to 0.20% w / v. Alternatively, in some embodiments, the effective amount of the composition to provide antimicrobial effect is 0.06 to 0.19% w / v. Alternatively, in some embodiments, the effective amount of the composition to provide antimicrobial effect is 0.06 to 0.18% w / v. Alternatively, in some embodiments, the effective amount of the composition to provide antimicrobial benefit is 0.06-0.17% w / v. Alternatively, in some embodiments, the effective amount of the composition to provide antimicrobial benefit is 0.06-0.16% w / v. Alternatively, in some embodiments, the effective amount of the composition to provide antimicrobial benefit is 0.06-0.15% w / v. Alternatively, in some embodiments, the effective amount of the composition to provide antimicrobial benefit is 0.06-0.14% w / v.Alternatively, in some embodiments, the effective amount of the composition to provide antimicrobial effect is 0.06-0.13% w / v. Alternatively, in some embodiments, the effective amount of the composition to provide antimicrobial effect is 0.06-0.12% w / v. Alternatively, in some embodiments, the effective amount of the composition to provide antimicrobial effect is 0.06-0.11% w / v. Alternatively, in some embodiments, the effective amount of the composition to provide antimicrobial effect is 0.06-0.10% w / v. Alternatively, in some embodiments, the effective amount of the composition to provide antimicrobial effect is 0.06-0.09% w / v. Alternatively, in some embodiments, the effective amount of the composition to provide antimicrobial effect is 0.06-0.08% w / v. Alternatively, in some embodiments, the effective amount of the composition to provide antimicrobial effect is 0.06-0.07% w / v.

[0124] In some embodiments, the effective amount of the antimicrobial composition to provide an antimicrobial effect is 0.06, or 0.07, or 0.08, or 0.08, or 0.1, or 0.11, or 0.12, or 0.13, or 0.14, or 0.14, or 0.16, or 0.17, or 0.18, or 0.09, or 0.2, or 0.21, or 0.22, or 0.23, or 0.24, or 0.25, or 0.26, or 0.27, or 0.28, or 0.29, or 0.3, or 0.31, or 0.32, or 0.33, or 0.34, or 0.35, or 0.36, or 0.37, or 0.38, or 0.39, or 0.4, or 0.41, or 0.42, or 0.43, or 0.44, or 0.45, or 0.46, or 0.47, or 0.48, or 0.49, or 0.5% w / v.

[0125] In some aspects, the present disclosure provides antimicrobial compositions comprising phenylhexanol, terpineol, isoeugenol, and coumarin.

[0126] Alternatively, in some aspects, the present disclosure provides for the use of an antimicrobial composition comprising phenylhexanol, terpineol, isoeugenol, and coumarin.

[0127] Alternatively, the present disclosure provides a non-therapeutic method of affecting microbial activity, the method comprising treating a substrate containing microorganisms with a composition comprising phenylhexanol, terpineol, isoeugenol, and coumarin, wherein the substrate is treated with an effective amount of the composition to provide an antimicrobial effect.

[0128] In some aspects, the present disclosure provides antimicrobially active consumer products comprising phenylhexanol, terpineol, isoeugenol, and coumarin.

[0129] Alternatively, in some aspects, the present disclosure provides for the use of, or methods of using, an antimicrobial composition comprising phenylhexanol, terpineol, isoeugenol, and coumarin to make an antimicrobially active consumer product.

[0130] In some aspects, the present disclosure provides a non-therapeutic method of affecting microbial activity, the method comprising treating a substrate containing microorganisms with an antimicrobially active consumer product comprising phenylhexanol, terpineol, isoeugenol, and coumarin, wherein the substrate is treated with an effective amount of the composition to provide an antimicrobial effect.

[0131] In some embodiments, the ratio of fragrance ingredients can provide a synergistic antimicrobial effect and impart a desirable, balanced, and / or appealing hedonic performance. In some embodiments, the ratio of phenylhexanol, terpineol, isoeugenol, and coumarin is 5:1:1:2. Alternatively, in some embodiments, the ratio of phenylhexanol, terpineol, isoeugenol, and coumarin is 2:2:2:4. Alternatively, in some embodiments, the ratio of phenylhexanol, terpineol, isoeugenol, and coumarin is 3.2:3.1:2.6:0.5. Alternatively, in some embodiments, the ratio of phenylhexanol, terpineol, isoeugenol, and coumarin is 1:5:3:1. Alternatively, in some embodiments, the ratio of phenylhexanol, terpineol, isoeugenol, and coumarin is 1:7:1:1.

[0132] In some embodiments, the effective amount of the composition to provide antimicrobial effect is 0.03-0.5% w / v. Alternatively, in some embodiments, the effective amount of the composition to provide antimicrobial effect is 0.04-0.5% w / v. Alternatively, in some embodiments, the effective amount of the composition to provide antimicrobial effect is 0.05-0.5% w / v. Alternatively, in some embodiments, the effective amount of the composition to provide antimicrobial effect is 0.06-0.5% w / v. Alternatively, in some embodiments, the effective amount of the composition to provide antimicrobial effect is 0.07-0.5% w / v. Alternatively, in some embodiments, the effective amount of the composition to provide antimicrobial effect is 0.08-0.5% w / v. Alternatively, in some embodiments, the effective amount of the composition to provide antimicrobial effect is 0.09-0.5% w / v. Alternatively, in some embodiments, the effective amount of the composition to provide antimicrobial effect is 0.10-0.5% w / v. Alternatively, in some embodiments, the effective amount of the composition to provide antimicrobial effect is 0.11 to 0.5% w / v. Alternatively, in some embodiments, the effective amount of the composition to provide antimicrobial effect is 0.12 to 0.5% w / v. Alternatively, in some embodiments, the effective amount of the composition to provide antimicrobial effect is 0.13 to 0.5% w / v. Alternatively, in some embodiments, the effective amount of the composition to provide antimicrobial effect is 0.14 to 0.5% w / v. Alternatively, in some embodiments, the effective amount of the composition to provide antimicrobial effect is 0.15 to 0.5% w / v. Alternatively, in some embodiments, the effective amount of the composition to provide antimicrobial effect is 0.16 to 0.5% w / v. Alternatively, in some embodiments, the effective amount of the composition to provide antimicrobial effect is 0.17 to 0.5% w / v. Alternatively, in some embodiments, the effective amount of the composition to provide antimicrobial effect is 0.18 to 0.5% w / v. Alternatively, in some embodiments, the effective amount of the composition to provide antimicrobial benefit is 0.19-0.5% w / v. Alternatively, in some embodiments, the effective amount of the composition to provide antimicrobial benefit is 0.20-0.5% w / v. Alternatively, in some embodiments, the effective amount of the composition to provide antimicrobial benefit is 0.21-0.5% w / v.Alternatively, in some embodiments, the effective amount of the composition to provide antimicrobial effect is 0.22-0.5% w / v. Alternatively, in some embodiments, the effective amount of the composition to provide antimicrobial effect is 0.23-0.5% w / v. Alternatively, in some embodiments, the effective amount of the composition to provide antimicrobial effect is 0.24-0.5% w / v. Alternatively, in some embodiments, the effective amount of the composition to provide antimicrobial effect is 0.25-0.5% w / v. Alternatively, in some embodiments, the effective amount of the composition to provide antimicrobial effect is 0.26-0.5% w / v. Alternatively, in some embodiments, the effective amount of the composition to provide antimicrobial effect is 0.27-0.5% w / v. Alternatively, in some embodiments, the effective amount of the composition to provide antimicrobial effect is 0.28-0.5% w / v. Alternatively, in some embodiments, the effective amount of the composition to provide antimicrobial effect is 0.29-0.5% w / v. Alternatively, in some embodiments, the effective amount of the composition to provide antimicrobial effect is 0.30 to 0.5% w / v. Alternatively, in some embodiments, the effective amount of the composition to provide antimicrobial effect is 0.31 to 0.5% w / v. Alternatively, in some embodiments, the effective amount of the composition to provide antimicrobial effect is 0.32 to 0.5% w / v. Alternatively, in some embodiments, the effective amount of the composition to provide antimicrobial effect is 0.33 to 0.5% w / v. Alternatively, in some embodiments, the effective amount of the composition to provide antimicrobial effect is 0.34 to 0.5% w / v. Alternatively, in some embodiments, the effective amount of the composition to provide antimicrobial effect is 0.35 to 0.5% w / v. Alternatively, in some embodiments, the effective amount of the composition to provide antimicrobial effect is 0.36 to 0.5% w / v. Alternatively, in some embodiments, the effective amount of the composition to provide antimicrobial effect is 0.37 to 0.5% w / v. Alternatively, in some embodiments, the effective amount of the composition to provide antimicrobial benefit is 0.38-0.5% w / v. Alternatively, in some embodiments, the effective amount of the composition to provide antimicrobial benefit is 0.39-0.5% w / v. Alternatively, in some embodiments, the effective amount of the composition to provide antimicrobial benefit is 0.40-0.5% w / v.Alternatively, in some embodiments, the effective amount of the composition to provide antimicrobial effect is 0.41 to 0.5% w / v. Alternatively, in some embodiments, the effective amount of the composition to provide antimicrobial effect is 0.42 to 0.5% w / v. Alternatively, in some embodiments, the effective amount of the composition to provide antimicrobial effect is 0.43 to 0.5% w / v. Alternatively, in some embodiments, the effective amount of the composition to provide antimicrobial effect is 0.44 to 0.5% w / v. Alternatively, in some embodiments, the effective amount of the composition to provide antimicrobial effect is 0.45 to 0.5% w / v. Alternatively, in some embodiments, the effective amount of the composition to provide antimicrobial effect is 0.46 to 0.5% w / v. Alternatively, in some embodiments, the effective amount of the composition to provide antimicrobial effect is 0.47 to 0.5% w / v. Alternatively, in some embodiments, the effective amount of the composition to provide antimicrobial effect is 0.48 to 0.5% w / v. Alternatively, in some embodiments, the effective amount of the composition to provide antimicrobial benefit is 0.49-0.5% w / v.

[0133] Alternatively, in some embodiments, the effective amount of the composition for providing antimicrobial effect is 0.03 to 0.49% w / v. Alternatively, in some embodiments, the effective amount of the composition for providing antimicrobial effect is 0.03 to 0.48% w / v. Alternatively, in some embodiments, the effective amount of the composition for providing antimicrobial effect is 0.03 to 0.47% w / v. Alternatively, in some embodiments, the effective amount of the composition for providing antimicrobial effect is 0.03 to 0.46% w / v. Alternatively, in some embodiments, the effective amount of the composition for providing antimicrobial effect is 0.03 to 0.45% w / v. Alternatively, in some embodiments, the effective amount of the composition for providing antimicrobial effect is 0.03 to 0.44% w / v. Alternatively, in some embodiments, the effective amount of the composition for providing antimicrobial effect is 0.03 to 0.43% w / v. Alternatively, in some embodiments, the effective amount of the composition for providing antimicrobial effect is 0.03 to 0.42% w / v. Alternatively, in some embodiments, the effective amount of the composition for providing antimicrobial effect is 0.03 to 0.41% w / v. Alternatively, in some embodiments, the effective amount of the composition for providing antimicrobial effect is 0.03 to 0.40% w / v. Alternatively, in some embodiments, the effective amount of the composition for providing antimicrobial effect is 0.03 to 0.39% w / v. Alternatively, in some embodiments, the effective amount of the composition for providing antimicrobial effect is 0.03 to 0.38% w / v. Alternatively, in some embodiments, the effective amount of the composition for providing antimicrobial effect is 0.03 to 0.37% w / v. Alternatively, in some embodiments, the effective amount of the composition for providing antimicrobial effect is 0.03 to 0.36% w / v. Alternatively, in some embodiments, the effective amount of the composition to provide antimicrobial benefit is 0.03-0.35% w / v. Alternatively, in some embodiments, the effective amount of the composition to provide antimicrobial benefit is 0.03-0.34% w / v. Alternatively, in some embodiments, the effective amount of the composition to provide antimicrobial benefit is 0.03-0.33% w / v. Alternatively, in some embodiments, the effective amount of the composition to provide antimicrobial benefit is 0.03-0.32% w / v.Alternatively, in some embodiments, the effective amount of the composition to provide antimicrobial benefit is 0.03-0.31% w / v.

[0134] In some embodiments, the effective amount of the antimicrobial composition to provide an antimicrobial effect is 0.03, or 0.04, or 0.05, or 0.06, or 0.07, or 0.08, or 0.08, or 0.1, or 0.11, or 0.12, or 0.13, or 0.14, or 0.14, or 0.16, or 0.17, or 0.18, or 0.09, or 0.2, or 0.21, or 0.22, or 0.23, or 0.24, or 0. 0.25, or 0.26, or 0.27, or 0.28, or 0.29, or 0.3, or 0.31, or 0.32, or 0.33, or 0.34, or 0.35, or 0.36, or 0.37, or 0.38, or 0.39, or 0.4, or 0.41, or 0.42, or 0.43, or 0.44, or 0.45, or 0.46, or 0.47, or 0.48, or 0.49, or 0.5% w / v.

[0135] In some embodiments, the present disclosure provides antimicrobial compositions comprising eugenol F, phenylhexanol, and carbinol lily of the valley.

[0136] Alternatively, in some embodiments, the present disclosure provides for the use of an antimicrobial composition comprising eugenol F, phenylhexanol, and carbinol lily of the valley.

[0137] Alternatively, the present disclosure provides a non-therapeutic method of affecting microbial activity, the method comprising treating a substrate containing microorganisms with a composition comprising eugenol F, phenylhexanol, and carbinol muguet, wherein the substrate is treated with an effective amount of the composition to provide an antimicrobial effect.

[0138] In some embodiments, the present disclosure provides antimicrobially active consumer products comprising eugenol F, phenylhexanol, and carbinol lily of the valley.

[0139] Alternatively, in some embodiments, the present disclosure provides for the use of, or methods of using, an antimicrobial composition comprising eugenol F, phenylhexanol, and carbinol lily of the valley to manufacture an antimicrobially active consumer product.

[0140] In some aspects, the present disclosure provides a non-therapeutic method of affecting microbial activity, the method comprising treating a substrate containing microorganisms with an antimicrobially active consumer product comprising eugenol F, phenylhexanol, and carbinol muguet, wherein the substrate is treated with an effective amount of the composition to provide an antimicrobial effect.

[0141] In some embodiments, the ratio of fragrance ingredients can provide a synergistic antimicrobial effect and impart desirable, balanced, and / or appealing hedonic performance. In some embodiments, the ratio of eugenol F, phenylhexanol, and carbinol lily of the valley is 1:5:10. Alternatively, in some embodiments, the ratio of eugenol F, phenylhexanol, and carbinol lily of the valley is 1:10:9. Alternatively, in some embodiments, the ratio of eugenol F, phenylhexanol, and carbinol lily of the valley is 2:5:3. Alternatively, in some embodiments, the ratio of eugenol F, phenylhexanol, and carbinol lily of the valley is 5:3:2. Alternatively, in some embodiments, the ratio of eugenol F, phenylhexanol, and carbinol lily of the valley is 3:3:4.

[0142] In some embodiments, the effective amount of the composition to provide antimicrobial benefit is 0.06-0.5% w / v. Alternatively, in some embodiments, the effective amount of the composition to provide antimicrobial benefit is 0.07-0.5% w / v. Alternatively, in some embodiments, the effective amount of the composition to provide antimicrobial benefit is 0.08-0.5% w / v. Alternatively, in some embodiments, the effective amount of the composition to provide antimicrobial benefit is 0.09-0.5% w / v. Alternatively, in some embodiments, the effective amount of the composition to provide antimicrobial benefit is 0.10-0.5% w / v. Alternatively, in some embodiments, the effective amount of the composition to provide antimicrobial benefit is 0.11-0.5% w / v. Alternatively, in some embodiments, the effective amount of the composition to provide antimicrobial benefit is 0.12-0.5% w / v. Alternatively, in some embodiments, the effective amount of the composition to provide antimicrobial benefit is 0.13-0.5% w / v. Alternatively, in some embodiments, the effective amount of the composition to provide antimicrobial effect is 0.14 to 0.5% w / v. Alternatively, in some embodiments, the effective amount of the composition to provide antimicrobial effect is 0.15 to 0.5% w / v. Alternatively, in some embodiments, the effective amount of the composition to provide antimicrobial effect is 0.16 to 0.5% w / v. Alternatively, in some embodiments, the effective amount of the composition to provide antimicrobial effect is 0.17 to 0.5% w / v. Alternatively, in some embodiments, the effective amount of the composition to provide antimicrobial effect is 0.18 to 0.5% w / v. Alternatively, in some embodiments, the effective amount of the composition to provide antimicrobial effect is 0.19 to 0.5% w / v. Alternatively, in some embodiments, the effective amount of the composition to provide antimicrobial effect is 0.20 to 0.5% w / v. Alternatively, in some embodiments, the effective amount of the composition to provide antimicrobial effect is 0.21 to 0.5% w / v. Alternatively, in some embodiments, the effective amount of the composition to provide antimicrobial benefit is 0.22-0.5% w / v. Alternatively, in some embodiments, the effective amount of the composition to provide antimicrobial benefit is 0.23-0.5% w / v. Alternatively, in some embodiments, the effective amount of the composition to provide antimicrobial benefit is 0.24-0.5% w / v.Alternatively, in some embodiments, the effective amount of the composition to provide antimicrobial effect is 0.25-0.5% w / v. Alternatively, in some embodiments, the effective amount of the composition to provide antimicrobial effect is 0.26-0.5% w / v. Alternatively, in some embodiments, the effective amount of the composition to provide antimicrobial effect is 0.27-0.5% w / v. Alternatively, in some embodiments, the effective amount of the composition to provide antimicrobial effect is 0.28-0.5% w / v. Alternatively, in some embodiments, the effective amount of the composition to provide antimicrobial effect is 0.29-0.5% w / v. Alternatively, in some embodiments, the effective amount of the composition to provide antimicrobial effect is 0.30-0.5% w / v. Alternatively, in some embodiments, the effective amount of the composition to provide antimicrobial effect is 0.31-0.5% w / v. Alternatively, in some embodiments, the effective amount of the composition to provide antimicrobial effect is 0.32-0.5% w / v. Alternatively, in some embodiments, the effective amount of the composition to provide antimicrobial effect is 0.33 to 0.5% w / v. Alternatively, in some embodiments, the effective amount of the composition to provide antimicrobial effect is 0.34 to 0.5% w / v. Alternatively, in some embodiments, the effective amount of the composition to provide antimicrobial effect is 0.35 to 0.5% w / v. Alternatively, in some embodiments, the effective amount of the composition to provide antimicrobial effect is 0.36 to 0.5% w / v. Alternatively, in some embodiments, the effective amount of the composition to provide antimicrobial effect is 0.37 to 0.5% w / v. Alternatively, in some embodiments, the effective amount of the composition to provide antimicrobial effect is 0.38 to 0.5% w / v. Alternatively, in some embodiments, the effective amount of the composition to provide antimicrobial effect is 0.39 to 0.5% w / v. Alternatively, in some embodiments, the effective amount of the composition to provide antimicrobial effect is 0.40 to 0.5% w / v. Alternatively, in some embodiments, the effective amount of the composition to provide antimicrobial benefit is 0.41-0.5% w / v. Alternatively, in some embodiments, the effective amount of the composition to provide antimicrobial benefit is 0.42-0.5% w / v. Alternatively, in some embodiments, the effective amount of the composition to provide antimicrobial benefit is 0.43-0.5% w / v.Alternatively, in some embodiments, the effective amount of the composition to provide antimicrobial benefit is 0.44-0.5% w / v. Alternatively, in some embodiments, the effective amount of the composition to provide antimicrobial benefit is 0.45-0.5% w / v. Alternatively, in some embodiments, the effective amount of the composition to provide antimicrobial benefit is 0.46-0.5% w / v. Alternatively, in some embodiments, the effective amount of the composition to provide antimicrobial benefit is 0.47-0.5% w / v. Alternatively, in some embodiments, the effective amount of the composition to provide antimicrobial benefit is 0.48-0.5% w / v. Alternatively, in some embodiments, the effective amount of the composition to provide antimicrobial benefit is 0.49-0.5% w / v.

[0143] Alternatively, in some embodiments, the effective amount of the composition for providing antimicrobial effect is 0.06 to 0.49% w / v. Alternatively, in some embodiments, the effective amount of the composition for providing antimicrobial effect is 0.06 to 0.48% w / v. Alternatively, in some embodiments, the effective amount of the composition for providing antimicrobial effect is 0.06 to 0.47% w / v. Alternatively, in some embodiments, the effective amount of the composition for providing antimicrobial effect is 0.06 to 0.46% w / v. Alternatively, in some embodiments, the effective amount of the composition for providing antimicrobial effect is 0.06 to 0.45% w / v. Alternatively, in some embodiments, the effective amount of the composition for providing antimicrobial effect is 0.06 to 0.44% w / v. Alternatively, in some embodiments, the effective amount of the composition for providing antimicrobial effect is 0.06 to 0.43% w / v. Alternatively, in some embodiments, the effective amount of the composition for providing antimicrobial effect is 0.06 to 0.42% w / v. Alternatively, in some embodiments, the effective amount of the composition for providing antimicrobial effect is 0.06 to 0.41% w / v. Alternatively, in some embodiments, the effective amount of the composition for providing antimicrobial effect is 0.06 to 0.40% w / v. Alternatively, in some embodiments, the effective amount of the composition for providing antimicrobial effect is 0.06 to 0.39% w / v. Alternatively, in some embodiments, the effective amount of the composition for providing antimicrobial effect is 0.06 to 0.38% w / v. Alternatively, in some embodiments, the effective amount of the composition for providing antimicrobial effect is 0.06 to 0.37% w / v. Alternatively, in some embodiments, the effective amount of the composition for providing antimicrobial effect is 0.06 to 0.36% w / v. Alternatively, in some embodiments, the effective amount of the composition to provide antimicrobial benefit is 0.06-0.35% w / v. Alternatively, in some embodiments, the effective amount of the composition to provide antimicrobial benefit is 0.06-0.34% w / v. Alternatively, in some embodiments, the effective amount of the composition to provide antimicrobial benefit is 0.06-0.33% w / v. Alternatively, in some embodiments, the effective amount of the composition to provide antimicrobial benefit is 0.06-0.32% w / v.Alternatively, in some embodiments, the effective amount of the composition to provide antimicrobial effect is 0.06 to 0.31% w / v. Alternatively, in some embodiments, the effective amount of the composition to provide antimicrobial effect is 0.06 to 0.30% w / v. Alternatively, in some embodiments, the effective amount of the composition to provide antimicrobial effect is 0.06 to 0.29% w / v. Alternatively, in some embodiments, the effective amount of the composition to provide antimicrobial effect is 0.06 to 0.28% w / v. Alternatively, in some embodiments, the effective amount of the composition to provide antimicrobial effect is 0.06 to 0.27% w / v. Alternatively, in some embodiments, the effective amount of the composition to provide antimicrobial effect is 0.06 to 0.26% w / v. Alternatively, in some embodiments, the effective amount of the composition to provide antimicrobial effect is 0.06 to 0.25% w / v. Alternatively, in some embodiments, the effective amount of the composition to provide antimicrobial effect is 0.06 to 0.24% w / v. Alternatively, in some embodiments, the effective amount of the composition to provide antimicrobial effect is 0.06 to 0.23% w / v. Alternatively, in some embodiments, the effective amount of the composition to provide antimicrobial effect is 0.06 to 0.22% w / v. Alternatively, in some embodiments, the effective amount of the composition to provide antimicrobial effect is 0.06 to 0.21% w / v. Alternatively, in some embodiments, the effective amount of the composition to provide antimicrobial effect is 0.06 to 0.20% w / v. Alternatively, in some embodiments, the effective amount of the composition to provide antimicrobial effect is 0.06 to 0.19% w / v. Alternatively, in some embodiments, the effective amount of the composition to provide antimicrobial effect is 0.06 to 0.18% w / v. Alternatively, in some embodiments, the effective amount of the composition to provide antimicrobial benefit is 0.06-0.17% w / v. Alternatively, in some embodiments, the effective amount of the composition to provide antimicrobial benefit is 0.06-0.16% w / v. Alternatively, in some embodiments, the effective amount of the composition to provide antimicrobial benefit is 0.06-0.15% w / v. Alternatively, in some embodiments, the effective amount of the composition to provide antimicrobial benefit is 0.06-0.14% w / v.Alternatively, in some embodiments, the effective amount of the composition to provide antimicrobial effect is 0.06-0.13% w / v. Alternatively, in some embodiments, the effective amount of the composition to provide antimicrobial effect is 0.06-0.12% w / v. Alternatively, in some embodiments, the effective amount of the composition to provide antimicrobial effect is 0.06-0.11% w / v. Alternatively, in some embodiments, the effective amount of the composition to provide antimicrobial effect is 0.06-0.10% w / v. Alternatively, in some embodiments, the effective amount of the composition to provide antimicrobial effect is 0.06-0.09% w / v. Alternatively, in some embodiments, the effective amount of the composition to provide antimicrobial effect is 0.06-0.08% w / v. Alternatively, in some embodiments, the effective amount of the composition to provide antimicrobial effect is 0.06-0.07% w / v.

[0144] In some embodiments, the effective amount of the antimicrobial composition to provide an antimicrobial effect is 0.06, or 0.07, or 0.08, or 0.09, or 0.1, or 0.11, or 0.12, or 0.13, or 0.14, or 0.15, or 0.16, or 0.17, or 0.18, or 0.19, or 0.2, or 0.21, or 0.22, or 0.23, or 0.24, or 0.25, or 0.26, or 0.27, or 0.28, or 0.29, or 0.3, or 0.31, or 0.32, or 0.33, or 0.34, or 0.35, or 0.36, or 0.37, or 0.38, or 0.39, or 0.4, or 0.41, or 0.42, or 0.43, or 0.44, or 0.45, or 0.46, or 0.47, or 0.48, or 0.49, or 0.5% w / v.

[0145] In some embodiments, the present disclosure provides an antimicrobial composition comprising eugenol F, phenylhexanol, carbinol muguet, and benzyl acetate.

[0146] Alternatively, in some embodiments, the present disclosure provides for the use of an antimicrobial composition comprising eugenol F, phenylhexanol, carbinol muguet, and benzyl acetate.

[0147] Alternatively, the present disclosure provides a non-therapeutic method of affecting microbial activity, the method comprising treating a substrate containing microorganisms with a composition comprising eugenol F, phenylhexanol, carbinol muguet, and benzyl acetate, wherein the substrate is treated with an effective amount of the composition to provide an antimicrobial effect.

[0148] In some embodiments, the present disclosure provides antimicrobially active consumer products comprising eugenol F, phenylhexanol, carbinol lily of the valley, and benzyl acetate.

[0149] Alternatively, in some embodiments, the present disclosure provides for the use of, or methods of using, an antimicrobial composition comprising eugenol F, phenylhexanol, carbinol lily of the valley, and benzyl acetate to manufacture an antimicrobially active consumer product.

[0150] In some aspects, the present disclosure provides a non-therapeutic method of affecting microbial activity, the method comprising treating a substrate containing microorganisms with an antimicrobially active consumer product comprising eugenol F, phenylhexanol, carbinol muguet, and benzyl acetate, wherein the substrate is treated with an effective amount of the composition to provide an antimicrobial effect.

[0151] In some embodiments, the ratio of fragrance ingredients can provide a synergistic antimicrobial effect and impart desirable, balanced, and / or appealing hedonic performance. In some embodiments, the ratio of eugenol F, phenylhexanol, carbinol lily of the valley, and benzyl acetate is 1:5:10:10. Alternatively, in some embodiments, the ratio of eugenol F, phenylhexanol, carbinol lily of the valley, and benzyl acetate is 1:8:8:3. Alternatively, in some embodiments, the ratio of eugenol F, phenylhexanol, carbinol lily of the valley, and benzyl acetate is 3:1:2:4. Alternatively, in some embodiments, the ratio of eugenol F, phenylhexanol, carbinol lily of the valley, and benzyl acetate is 2:6:1:1. Alternatively, in some embodiments, the ratio of eugenol F, phenylhexanol, carbinol lily of the valley, and benzyl acetate is 1:2:6:1.

[0152] In some embodiments, the effective amount of the composition to provide antimicrobial benefit is 0.10-0.6% w / v. Alternatively, in some embodiments, the effective amount of the composition to provide antimicrobial benefit is 0.11-0.6% w / v. Alternatively, in some embodiments, the effective amount of the composition to provide antimicrobial benefit is 0.12-0.6% w / v. Alternatively, in some embodiments, the effective amount of the composition to provide antimicrobial benefit is 0.13-0.6% w / v. Alternatively, in some embodiments, the effective amount of the composition to provide antimicrobial benefit is 0.14-0.6% w / v. Alternatively, in some embodiments, the effective amount of the composition to provide antimicrobial benefit is 0.15-0.6% w / v. Alternatively, in some embodiments, the effective amount of the composition to provide antimicrobial benefit is 0.16-0.6% w / v. Alternatively, in some embodiments, the effective amount of the composition to provide antimicrobial benefit is 0.17-0.6% w / v. Alternatively, in some embodiments, the effective amount of the composition to provide antimicrobial effect is 0.18-0.6% w / v. Alternatively, in some embodiments, the effective amount of the composition to provide antimicrobial effect is 0.19-0.6% w / v. Alternatively, in some embodiments, the effective amount of the composition to provide antimicrobial effect is 0.20-0.6% w / v. Alternatively, in some embodiments, the effective amount of the composition to provide antimicrobial effect is 0.21-0.6% w / v. Alternatively, in some embodiments, the effective amount of the composition to provide antimicrobial effect is 0.22-0.6% w / v. Alternatively, in some embodiments, the effective amount of the composition to provide antimicrobial effect is 0.23-0.6% w / v. Alternatively, in some embodiments, the effective amount of the composition to provide antimicrobial effect is 0.24-0.6% w / v. Alternatively, in some embodiments, the effective amount of the composition to provide antimicrobial effect is 0.25-0.6% w / v. Alternatively, in some embodiments, the effective amount of the composition to provide antimicrobial benefit is 0.26-0.6% w / v. Alternatively, in some embodiments, the effective amount of the composition to provide antimicrobial benefit is 0.27-0.6% w / v. Alternatively, in some embodiments, the effective amount of the composition to provide antimicrobial benefit is 0.28-0.6% w / v.Alternatively, in some embodiments, the effective amount of the composition to provide antimicrobial effect is 0.29-0.6% w / v. Alternatively, in some embodiments, the effective amount of the composition to provide antimicrobial effect is 0.30-0.6% w / v. Alternatively, in some embodiments, the effective amount of the composition to provide antimicrobial effect is 0.31-0.6% w / v. Alternatively, in some embodiments, the effective amount of the composition to provide antimicrobial effect is 0.32-0.6% w / v. Alternatively, in some embodiments, the effective amount of the composition to provide antimicrobial effect is 0.33-0.6% w / v. Alternatively, in some embodiments, the effective amount of the composition to provide antimicrobial effect is 0.34-0.6% w / v. Alternatively, in some embodiments, the effective amount of the composition to provide antimicrobial effect is 0.35-0.6% w / v. Alternatively, in some embodiments, the effective amount of the composition to provide antimicrobial effect is 0.36-0.6% w / v. Alternatively, in some embodiments, the effective amount of the composition to provide antimicrobial effect is 0.37-0.6% w / v. Alternatively, in some embodiments, the effective amount of the composition to provide antimicrobial effect is 0.38-0.6% w / v. Alternatively, in some embodiments, the effective amount of the composition to provide antimicrobial effect is 0.39-0.6% w / v. Alternatively, in some embodiments, the effective amount of the composition to provide antimicrobial effect is 0.40-0.6% w / v. Alternatively, in some embodiments, the effective amount of the composition to provide antimicrobial effect is 0.41-0.6% w / v. Alternatively, in some embodiments, the effective amount of the composition to provide antimicrobial effect is 0.42-0.6% w / v. Alternatively, in some embodiments, the effective amount of the composition to provide antimicrobial effect is 0.43-0.6% w / v. Alternatively, in some embodiments, the effective amount of the composition to provide antimicrobial effect is 0.44-0.6% w / v. Alternatively, in some embodiments, the effective amount of the composition to provide antimicrobial benefit is 0.45-0.6% w / v. Alternatively, in some embodiments, the effective amount of the composition to provide antimicrobial benefit is 0.46-0.6% w / v. Alternatively, in some embodiments, the effective amount of the composition to provide antimicrobial benefit is 0.47-0.6% w / v.Alternatively, in some embodiments, the effective amount of the composition to provide antimicrobial effect is 0.48-0.6% w / v. Alternatively, in some embodiments, the effective amount of the composition to provide antimicrobial effect is 0.49-0.6% w / v. Alternatively, in some embodiments, the effective amount of the composition to provide antimicrobial effect is 0.50-0.6% w / v. Alternatively, in some embodiments, the effective amount of the composition to provide antimicrobial effect is 0.51-0.6% w / v. Alternatively, in some embodiments, the effective amount of the composition to provide antimicrobial effect is 0.52-0.6% w / v. Alternatively, in some embodiments, the effective amount of the composition to provide antimicrobial effect is 0.53-0.6% w / v. Alternatively, in some embodiments, the effective amount of the composition to provide antimicrobial effect is 0.54-0.6% w / v. Alternatively, in some embodiments, the effective amount of the composition to provide antimicrobial effect is 0.55-0.6% w / v. Alternatively, in some embodiments, the effective amount of the composition to provide antimicrobial benefit is 0.56-0.6% w / v. Alternatively, in some embodiments, the effective amount of the composition to provide antimicrobial benefit is 0.57-0.6% w / v. Alternatively, in some embodiments, the effective amount of the composition to provide antimicrobial benefit is 0.58-0.6% w / v. Alternatively, in some embodiments, the effective amount of the composition to provide antimicrobial benefit is 0.59-0.6% w / v.

[0153] Alternatively, in some embodiments, the effective amount of the composition to provide antimicrobial effect is 0.1 to 0.59% w / v. Alternatively, in some embodiments, the effective amount of the composition to provide antimicrobial effect is 0.1 to 0.58% w / v. Alternatively, in some embodiments, the effective amount of the composition to provide antimicrobial effect is 0.1 to 0.57% w / v. Alternatively, in some embodiments, the effective amount of the composition to provide antimicrobial effect is 0.1 to 0.56% w / v. Alternatively, in some embodiments, the effective amount of the composition to provide antimicrobial effect is 0.1 to 0.55% w / v. Alternatively, in some embodiments, the effective amount of the composition to provide antimicrobial effect is 0.1 to 0.54% w / v. Alternatively, in some embodiments, the effective amount of the composition to provide antimicrobial effect is 0.1 to 0.53% w / v. Alternatively, in some embodiments, the effective amount of the composition to provide antimicrobial effect is 0.1 to 0.52% w / v. Alternatively, in some embodiments, the effective amount of the composition for providing antimicrobial effect is 0.1 to 0.51% w / v. Alternatively, in some embodiments, the effective amount of the composition for providing antimicrobial effect is 0.1 to 0.50% w / v. Alternatively, in some embodiments, the effective amount of the composition for providing antimicrobial effect is 0.1 to 0.49% w / v. Alternatively, in some embodiments, the effective amount of the composition for providing antimicrobial effect is 0.1 to 0.48% w / v. Alternatively, in some embodiments, the effective amount of the composition for providing antimicrobial effect is 0.1 to 0.47% w / v. Alternatively, in some embodiments, the effective amount of the composition for providing antimicrobial effect is 0.1 to 0.46% w / v. Alternatively, in some embodiments, the effective amount of the composition for providing antimicrobial effect is 0.1 to 0.45% w / v. Alternatively, in some embodiments, the effective amount of the composition for providing antimicrobial effect is 0.1 to 0.44% w / v. Alternatively, in some embodiments, the effective amount of the composition to provide antimicrobial benefit is 0.1-0.43% w / v, alternatively, in some embodiments, the effective amount of the composition to provide antimicrobial benefit is 0.1-0.42% w / v, alternatively, in some embodiments, the effective amount of the composition to provide antimicrobial benefit is 0.1-0.41% w / v.Alternatively, in some embodiments, the effective amount of the composition for providing antimicrobial effect is 0.1 to 0.40% w / v. Alternatively, in some embodiments, the effective amount of the composition for providing antimicrobial effect is 0.1 to 0.39% w / v. Alternatively, in some embodiments, the effective amount of the composition for providing antimicrobial effect is 0.1 to 0.38% w / v. Alternatively, in some embodiments, the effective amount of the composition for providing antimicrobial effect is 0.1 to 0.37% w / v. Alternatively, in some embodiments, the effective amount of the composition for providing antimicrobial effect is 0.1 to 0.36% w / v. Alternatively, in some embodiments, the effective amount of the composition for providing antimicrobial effect is 0.1 to 0.35% w / v. Alternatively, in some embodiments, the effective amount of the composition for providing antimicrobial effect is 0.1 to 0.34% w / v. Alternatively, in some embodiments, the effective amount of the composition for providing antimicrobial effect is 0.1 to 0.33% w / v. Alternatively, in some embodiments, the effective amount of the composition to provide antimicrobial effect is 0.1 to 0.32% w / v. Alternatively, in some embodiments, the effective amount of the composition to provide antimicrobial effect is 0.1 to 0.31% w / v. Alternatively, in some embodiments, the effective amount of the composition to provide antimicrobial effect is 0.1 to 0.30% w / v. Alternatively, in some embodiments, the effective amount of the composition to provide antimicrobial effect is 0.1 to 0.29% w / v. Alternatively, in some embodiments, the effective amount of the composition to provide antimicrobial effect is 0.1 to 0.28% w / v. Alternatively, in some embodiments, the effective amount of the composition to provide antimicrobial effect is 0.1 to 0.27% w / v. Alternatively, in some embodiments, the effective amount of the composition to provide antimicrobial effect is 0.1 to 0.26% w / v. Alternatively, in some embodiments, the effective amount of the composition to provide antimicrobial effect is 0.1 to 0.25% w / v. Alternatively, in some embodiments, the effective amount of the composition to provide antimicrobial benefit is 0.1-0.24% w / v. Alternatively, in some embodiments, the effective amount of the composition to provide antimicrobial benefit is 0.1-0.23% w / v. Alternatively, in some embodiments, the effective amount of the composition to provide antimicrobial benefit is 0.1-0.22% w / v.Alternatively, in some embodiments, the effective amount of the composition to provide antimicrobial effect is 0.1 to 0.21% w / v. Alternatively, in some embodiments, the effective amount of the composition to provide antimicrobial effect is 0.1 to 0.20% w / v. Alternatively, in some embodiments, the effective amount of the composition to provide antimicrobial effect is 0.1 to 0.19% w / v. Alternatively, in some embodiments, the effective amount of the composition to provide antimicrobial effect is 0.1 to 0.18% w / v. Alternatively, in some embodiments, the effective amount of the composition to provide antimicrobial effect is 0.1 to 0.17% w / v. Alternatively, in some embodiments, the effective amount of the composition to provide antimicrobial effect is 0.1 to 0.16% w / v. Alternatively, in some embodiments, the effective amount of the composition to provide antimicrobial effect is 0.1 to 0.15% w / v. Alternatively, in some embodiments, the effective amount of the composition to provide antimicrobial effect is 0.1 to 0.14% w / v. Alternatively, in some embodiments, the effective amount of the composition to provide antimicrobial benefit is 0.1-0.13% w / v. Alternatively, in some embodiments, the effective amount of the composition to provide antimicrobial benefit is 0.1-0.12% w / v. Alternatively, in some embodiments, the effective amount of the composition to provide antimicrobial benefit is 0.1-0.11% w / v.

[0154] In some embodiments, the effective amount of the antimicrobial composition to provide an antimicrobial effect is 0.1, or 0.11, or 0.12, or 0.13, or 0.14, or 0.14, or 0.16, or 0.17, or 0.18, or 0.09, or 0.2, or 0.21, or 0.22, or 0.23, or 0.24, or 0.25, or 0.26, or 0.27, or 0.28, or 0.29, or 0.3, or 0.31, or 0.32, or 0.33, or 0.34, or 0.35, or 0.36, or 0.37, or 0.38, or 0.39, or 0.4, or 0.41, or 0.42, or 0.43, or 0.44, or 0.45, or 0.46, or 0.47, or 0.48, or 0.49, or 0.5, or 0.51, or 0.52, or 0.53, or 0.54, or 0.55, or 0.56, or 0.57, or 0.58, or 0.59, or 0.6% w / v.

[0155] In some embodiments, the present disclosure provides antimicrobial compositions comprising phenylhexanol and at least one fragrance ingredient selected from the group consisting of heliopropanal, nerol, tetralinol, isoeugenol, terpineol, coumarin, eugenol F, carbinol lily of the valley, and benzyl acetate.

[0156] Alternatively, in some embodiments, the present disclosure provides for the use of an antimicrobial composition comprising phenylhexanol and at least one fragrance ingredient selected from the group consisting of heliopropanal, nerol, tetralinol, isoeugenol, terpineol, coumarin, eugenol F, carbinol lily of the valley, and benzyl acetate.

[0157] Alternatively, the present disclosure provides a non-therapeutic method of affecting microbial activity, the method comprising treating a substrate containing microorganisms with a composition comprising phenylhexanol and at least one fragrance ingredient selected from the group consisting of heliopropanal, nerol, tetralinol, isoeugenol, terpineol, coumarin, eugenol F, carbinol lily of the valley, and benzyl acetate, wherein the substrate is treated with an effective amount of the composition to provide an antimicrobial effect.

[0158] In some aspects, the present disclosure provides antimicrobially active consumer products comprising phenylhexanol and at least one fragrance ingredient selected from the group consisting of heliopropanal, nerol, tetralinol, isoeugenol, terpineol, coumarin, eugenol F, carbinol lily of the valley, and benzyl acetate.

[0159] Alternatively, in some aspects, the present disclosure provides for the use, or method of use, of an antimicrobial composition comprising phenylhexanol and at least one fragrance ingredient selected from the group consisting of heliopropanal, nerol, tetralinol, isoeugenol, terpineol, coumarin, eugenol F, carbinol lily of the valley, and benzyl acetate, to make an antimicrobially active consumer product.

[0160] In some aspects, the present disclosure provides a non-therapeutic method of affecting microbial activity, the method comprising treating a substrate containing microorganisms with a composition comprising phenylhexanol and at least one fragrance ingredient selected from the group consisting of heliopropanal, nerol, tetralinol, isoeugenol, terpineol, coumarin, eugenol F, carbinol lily of the valley, and benzyl acetate, wherein the substrate is treated with an effective amount of the composition to provide an antimicrobial effect.

[0161] In some aspects, the present disclosure provides antimicrobial compositions comprising anisaldehyde and at least one fragrance ingredient selected from the group consisting of heliotropin, terpineol, and heliopropanal.

[0162] Alternatively, in some aspects, the present disclosure provides for the use of an antimicrobial composition comprising anisaldehyde and at least one fragrance ingredient selected from the group consisting of heliotropin, terpineol, and heliopropanal.

[0163] Alternatively, the present disclosure provides a non-therapeutic method of affecting microbial activity, the method comprising treating a substrate containing microorganisms with a composition comprising anisaldehyde and at least one fragrance ingredient selected from the group consisting of heliotropin, terpineol, and heliopropanal, wherein the substrate is treated with an effective amount of the composition to provide an antimicrobial effect.

[0164] In some aspects, the present disclosure provides antimicrobially active consumer products comprising anisaldehyde and at least one fragrance ingredient selected from the group consisting of heliotropin, terpineol, and heliopropanal.

[0165] Alternatively, in some aspects, the present disclosure provides a use, or method of use, of an antimicrobial composition comprising anisaldehyde and at least one fragrance ingredient selected from the group consisting of heliotropin, terpineol, and heliopropanal to make an antimicrobially active consumer product.

[0166] In some aspects, the present disclosure provides a non-therapeutic method of affecting microbial activity, the method comprising treating a substrate containing microorganisms with a composition comprising anisaldehyde and at least one fragrance ingredient selected from the group consisting of heliotropin, terpineol, and heliopropanal, wherein the substrate is treated with an effective amount of the composition to provide an antimicrobial effect.

[0167] In some embodiments, the effective amount of phenylhexanol in the antibacterial composition is 500 to 6000 ppm. Alternatively, in some embodiments, the effective amount of phenylhexanol in the antibacterial composition is 1000 to 6000 ppm. Alternatively, in some embodiments, the effective amount of phenylhexanol in the antibacterial composition is 1500 to 6000 ppm. Alternatively, in some embodiments, the effective amount of phenylhexanol in the antibacterial composition is 2000 to 6000 ppm. Alternatively, in some embodiments, the effective amount of phenylhexanol in the antibacterial composition is 2500 to 6000 ppm. Alternatively, in some embodiments, the effective amount of phenylhexanol in the antibacterial composition is 3000 to 6000 ppm. Alternatively, in some embodiments, the effective amount of phenylhexanol in the antibacterial composition is 3500 to 6000 ppm. Alternatively, in some embodiments, the effective amount of phenylhexanol in the antibacterial composition is 4000 to 6000 ppm. Alternatively, in some embodiments, the effective amount of phenylhexanol in the antibacterial composition is 4500 to 6000 ppm. Alternatively, in some embodiments, the effective amount of phenylhexanol in the antibacterial composition is 5000 to 6000 ppm. Alternatively, in some embodiments, the effective amount of phenylhexanol in the antibacterial composition is 5500 to 6000 ppm.

[0168] Alternatively, in some embodiments, the effective amount of phenylhexanol in the antibacterial composition is 500 to 5,500 ppm. Alternatively, in some embodiments, the effective amount of phenylhexanol in the antibacterial composition is 500 to 5,000 ppm. Alternatively, in some embodiments, the effective amount of phenylhexanol in the antibacterial composition is 500 to 4,500 ppm. Alternatively, in some embodiments, the effective amount of phenylhexanol in the antibacterial composition is 500 to 4,000 ppm. Alternatively, in some embodiments, the effective amount of phenylhexanol in the antibacterial composition is 500 to 3,500 ppm. Alternatively, in some embodiments, the effective amount of phenylhexanol in the antibacterial composition is 500 to 3,000 ppm. Alternatively, in some embodiments, the effective amount of phenylhexanol in the antibacterial composition is 500 to 2,500 ppm. Alternatively, in some embodiments, the effective amount of phenylhexanol in the antibacterial composition is 500 to 2000 ppm. Alternatively, in some embodiments, the effective amount of phenylhexanol in the antibacterial composition is 500 to 1500 ppm. Alternatively, in some embodiments, the effective amount of phenylhexanol in the antibacterial composition is 500 to 1000 ppm.

[0169] In some embodiments, the effective amount of phenylhexanol in the antimicrobial composition is 500, or 1000, or 1500, or 2000, or 2500, or 3000, or 3500, or 4000, or 4500, or 5000, or 5500, or 6000% w / v.

[0170] In some embodiments, the effective amount of heliopropanal in the antibacterial composition is 2000 to 6000 ppm. Alternatively, in some embodiments, the effective amount of heliopropanal in the antibacterial composition is 2500 to 6000 ppm. Alternatively, in some embodiments, the effective amount of heliopropanal in the antibacterial composition is 3000 to 6000 ppm. Alternatively, in some embodiments, the effective amount of heliopropanal in the antibacterial composition is 3500 to 6000 ppm. Alternatively, in some embodiments, the effective amount of heliopropanal in the antibacterial composition is 4000 to 6000 ppm. Alternatively, in some embodiments, the effective amount of heliopropanal in the antibacterial composition is 4500 to 6000 ppm. Alternatively, in some embodiments, the effective amount of heliopropanal in the antibacterial composition is 5000 to 6000 ppm. Alternatively, in some embodiments, the effective amount of heliopropanal in the antimicrobial composition is 5500 to 6000 ppm.

[0171] Alternatively, in some embodiments, the effective amount of heliopropanal in the antibacterial composition is 2000 to 5500 ppm. Alternatively, in some embodiments, the effective amount of heliopropanal in the antibacterial composition is 2000 to 5000 ppm. Alternatively, in some embodiments, the effective amount of heliopropanal in the antibacterial composition is 2000 to 4500 ppm. Alternatively, in some embodiments, the effective amount of heliopropanal in the antibacterial composition is 2000 to 4000 ppm. Alternatively, in some embodiments, the effective amount of heliopropanal in the antibacterial composition is 2000 to 3500 ppm. Alternatively, in some embodiments, the effective amount of heliopropanal in the antibacterial composition is 2000 to 3000 ppm. Alternatively, in some embodiments, the effective amount of heliopropanal in the antibacterial composition is 2000 to 2500 ppm.

[0172] In some embodiments, the effective amount of heliopropanal in the antimicrobial composition is 2000, or 2500, or 3000, or 3500, or 4000, or 4500, or 5000, or 5500, or 6000 ppm.

[0173] In some embodiments, the effective amount of tetralinol in the antibacterial composition is 1000 to 4000 ppm. Alternatively, in some embodiments, the effective amount of tetralinol in the antibacterial composition is 1500 to 4000 ppm. Alternatively, in some embodiments, the effective amount of tetralinol in the antibacterial composition is 2000 to 4000 ppm. Alternatively, in some embodiments, the effective amount of tetralinol in the antibacterial composition is 2500 to 4000 ppm. Alternatively, in some embodiments, the effective amount of tetralinol in the antibacterial composition is 3000 to 4000 ppm. Alternatively, in some embodiments, the effective amount of tetralinol in the antibacterial composition is 3500 to 4000 ppm.

[0174] Alternatively, in some embodiments, the effective amount of tetralinol in the antibacterial composition is 1000 to 3500 ppm. Alternatively, in some embodiments, the effective amount of tetralinol in the antibacterial composition is 1000 to 3000 ppm. Alternatively, in some embodiments, the effective amount of tetralinol in the antibacterial composition is 1000 to 2500 ppm. Alternatively, in some embodiments, the effective amount of tetralinol in the antibacterial composition is 1000 to 2000 ppm. Alternatively, in some embodiments, the effective amount of tetralinol in the antibacterial composition is 1000 to 1500 ppm.

[0175] In some embodiments, the effective amount of tetralinol in the antimicrobial composition is 1000, or 1500, or 2000, or 2500, or 3000, or 3500, or 4000 ppm.

[0176] In some embodiments, the effective amount of isoeugenol in the antimicrobial composition is 500 to 3000 ppm. Alternatively, in some embodiments, the effective amount of isoeugenol in the antimicrobial composition is 1000 to 3000 ppm. Alternatively, in some embodiments, the effective amount of isoeugenol in the antimicrobial composition is 1500 to 3000 ppm. Alternatively, in some embodiments, the effective amount of isoeugenol in the antimicrobial composition is 2000 to 3000 ppm. Alternatively, in some embodiments, the effective amount of isoeugenol in the antimicrobial composition is 2500 to 3000 ppm.

[0177] Alternatively, in some embodiments, the effective amount of isoeugenol in the antimicrobial composition is 500 to 2500 ppm. Alternatively, in some embodiments, the effective amount of isoeugenol in the antimicrobial composition is 500 to 2000 ppm. Alternatively, in some embodiments, the effective amount of isoeugenol in the antimicrobial composition is 500 to 1500 ppm. Alternatively, in some embodiments, the effective amount of isoeugenol in the antimicrobial composition is 500 to 1000 ppm.

[0178] In some embodiments, the effective amount of isoeugenol in the antimicrobial composition is 500, or 1000, or 1500, or 2000, or 2500, or 3000 ppm.

[0179] In some embodiments, the effective amount of terpineol in the antimicrobial composition is 500 to 3000 ppm. Alternatively, in some embodiments, the effective amount of terpineol in the antimicrobial composition is 1000 to 3000 ppm. Alternatively, in some embodiments, the effective amount of terpineol in the antimicrobial composition is 1500 to 3000 ppm. Alternatively, in some embodiments, the effective amount of terpineol in the antimicrobial composition is 2000 to 3000 ppm. Alternatively, in some embodiments, the effective amount of terpineol in the antimicrobial composition is 2500 to 3000 ppm.

[0180] Alternatively, in some embodiments, the effective amount of terpineol in the antimicrobial composition is 500 to 2500 ppm. Alternatively, in some embodiments, the effective amount of terpineol in the antimicrobial composition is 500 to 2000 ppm. Alternatively, in some embodiments, the effective amount of terpineol in the antimicrobial composition is 500 to 1500 ppm. Alternatively, in some embodiments, the effective amount of terpineol in the antimicrobial composition is 500 to 1000 ppm.

[0181] In some embodiments, the effective amount of terpineol in the antimicrobial composition is 500, or 1000, or 1500, or 2000, or 2500, or 3000 ppm.

[0182] In some embodiments, the effective amount of coumarin in the antibacterial composition is 1000-3000 ppm. Alternatively, in some embodiments, the effective amount of coumarin in the antibacterial composition is 1500-3000 ppm. Alternatively, in some embodiments, the effective amount of coumarin in the antibacterial composition is 2000-3000 ppm. Alternatively, in some embodiments, the effective amount of coumarin in the antibacterial composition is 2500-3000 ppm.

[0183] Alternatively, in some embodiments, the effective amount of coumarin in the antibacterial composition is 1000 to 2500 ppm. Alternatively, in some embodiments, the effective amount of coumarin in the antibacterial composition is 1000 to 2000 ppm. Alternatively, in some embodiments, the effective amount of coumarin in the antibacterial composition is 1000 to 1500 ppm.

[0184] In some embodiments, the effective amount of coumarin in the antimicrobial composition is 1000, or 1500, or 2000, or 2500, or 3000 ppm.

[0185] In some embodiments, the effective amount of eugenol F in the antibacterial composition is 200 to 1000 ppm. Alternatively, in some embodiments, the effective amount of eugenol F in the antibacterial composition is 300 to 1000 ppm. Alternatively, in some embodiments, the effective amount of eugenol F in the antibacterial composition is 400 to 1000 ppm. Alternatively, in some embodiments, the effective amount of eugenol F in the antibacterial composition is 500 to 1000 ppm. Alternatively, in some embodiments, the effective amount of eugenol F in the antibacterial composition is 600 to 1000 ppm. Alternatively, in some embodiments, the effective amount of eugenol F in the antibacterial composition is 700 to 1000 ppm. Alternatively, in some embodiments, the effective amount of eugenol F in the antibacterial composition is 800 to 1000 ppm. Alternatively, in some embodiments, the effective amount of eugenol F in the antibacterial composition is 900 to 1000 ppm.

[0186] Alternatively, in some embodiments, the effective amount of eugenol F in the antibacterial composition is 200 to 900 ppm. Alternatively, in some embodiments, the effective amount of eugenol F in the antibacterial composition is 200 to 800 ppm. Alternatively, in some embodiments, the effective amount of eugenol F in the antibacterial composition is 200 to 700 ppm. Alternatively, in some embodiments, the effective amount of eugenol F in the antibacterial composition is 200 to 600 ppm. Alternatively, in some embodiments, the effective amount of eugenol F in the antibacterial composition is 200 to 500 ppm. Alternatively, in some embodiments, the effective amount of eugenol F in the antibacterial composition is 200 to 400 ppm. Alternatively, in some embodiments, the effective amount of eugenol F in the antibacterial composition is 200 to 300 ppm.

[0187] In some embodiments, the effective amount of eugenol F in the antimicrobial composition is 200, or 300, or 400, or 500, or 600, or 700, or 800, or 900, or 1000 ppm.

[0188] In some embodiments, the effective amount of carbinol lily of the valley in the antibacterial composition is 4000 to 7000 ppm. Alternatively, in some embodiments, the effective amount of carbinol lily of the valley in the antibacterial composition is 4500 to 7000 ppm. Alternatively, in some embodiments, the effective amount of carbinol lily of the valley in the antibacterial composition is 5000 to 7000 ppm. Alternatively, in some embodiments, the effective amount of carbinol lily of the valley in the antibacterial composition is 5500 to 7000 ppm. Alternatively, in some embodiments, the effective amount of carbinol lily of the valley in the antibacterial composition is 6000 to 7000 ppm. Alternatively, in some embodiments, the effective amount of carbinol lily of the valley in the antibacterial composition is 6500 to 7000 ppm.

[0189] Alternatively, in some embodiments, the effective amount of carbinol lily of the valley in the antibacterial composition is 4000 to 6500 ppm. Alternatively, in some embodiments, the effective amount of carbinol lily of the valley in the antibacterial composition is 4000 to 6000 ppm. Alternatively, in some embodiments, the effective amount of carbinol lily of the valley in the antibacterial composition is 4000 to 5500 ppm. Alternatively, in some embodiments, the effective amount of carbinol lily of the valley in the antibacterial composition is 4000 to 5000 ppm. Alternatively, in some embodiments, the effective amount of carbinol lily of the valley in the antibacterial composition is 4000 to 4500 ppm.

[0190] In some embodiments, the effective amount of carbinol lily of the valley in the antimicrobial composition is 4000, or 4500, or 5000, or 5500, or 6000 ppm.

[0191] In some embodiments, the effective amount of benzyl acetate in the antimicrobial composition is 4000-6000 ppm. Alternatively, in some embodiments, the effective amount of benzyl acetate in the antimicrobial composition is 4500-6000 ppm. Alternatively, in some embodiments, the effective amount of benzyl acetate in the antimicrobial composition is 5000-6000 ppm. Alternatively, in some embodiments, the effective amount of benzyl acetate in the antimicrobial composition is 5500-6000 ppm.

[0192] Alternatively, in some embodiments, the effective amount of benzyl acetate in the antimicrobial composition is 4000 to 5500 ppm. Alternatively, in some embodiments, the effective amount of benzyl acetate in the antimicrobial composition is 4000 to 5000 ppm. Alternatively, in some embodiments, the effective amount of benzyl acetate in the antimicrobial composition is 4000 to 4500 ppm.

[0193] In some embodiments, the effective amount of benzyl acetate in the antimicrobial composition is 4000, or 4500, or 5000, or 5500, or 6000 ppm.

[0194] In some embodiments, the effective amount of anisaldehyde in the antimicrobial composition is 2500-4500 ppm. Alternatively, in some embodiments, the effective amount of anisaldehyde in the antimicrobial composition is 3000-4500 ppm. Alternatively, in some embodiments, the effective amount of anisaldehyde in the antimicrobial composition is 3500-4500 ppm. Alternatively, in some embodiments, the effective amount of anisaldehyde in the antimicrobial composition is 4000-4500 ppm.

[0195] Alternatively, in some embodiments, the effective amount of anisaldehyde in the antimicrobial composition is 2500 to 4000 ppm. Alternatively, in some embodiments, the effective amount of anisaldehyde in the antimicrobial composition is 2500 to 3500 ppm. Alternatively, in some embodiments, the effective amount of anisaldehyde in the antimicrobial composition is 2500 to 3000 ppm.

[0196] In some embodiments, the effective amount of anisaldehyde in the antimicrobial composition is 2500, or 3000, or 3500, or 4000, or 4500 ppm.

[0197] In some embodiments, the effective amount of heliotropin in the antibacterial composition is 4000 to 6000 ppm. Alternatively, in some embodiments, the effective amount of heliotropin in the antibacterial composition is 4500 to 6000 ppm. Alternatively, in some embodiments, the effective amount of heliotropin in the antibacterial composition is 5000 to 6000 ppm. Alternatively, in some embodiments, the effective amount of heliotropin in the antibacterial composition is 5500 to 6000 ppm.

[0198] Alternatively, in some embodiments, the effective amount of heliotropin in the antibacterial composition is 4000 to 5500 ppm. Alternatively, in some embodiments, the effective amount of heliotropin in the antibacterial composition is 4000 to 5000 ppm. Alternatively, in some embodiments, the effective amount of heliotropin in the antibacterial composition is 4000 to 4500 ppm.

[0199] In some embodiments, the effective amount of heliotropin in the antimicrobial composition is 4000, or 4500, or 5000, or 5500, or 6000 ppm.

[0200] In some embodiments, the effective amount of decal in the antimicrobial composition is 1000-3000 ppm. Alternatively, in some embodiments, the effective amount of decal in the antimicrobial composition is 1500-3000 ppm. Alternatively, in some embodiments, the effective amount of decal in the antimicrobial composition is 2000-3000 ppm. Alternatively, in some embodiments, the effective amount of decal in the antimicrobial composition is 2500-3000 ppm.

[0201] Alternatively, in some embodiments, the effective amount of decal in the antimicrobial composition is 1000-2500 ppm. Alternatively, in some embodiments, the effective amount of decal in the antimicrobial composition is 1000-2000 ppm. Alternatively, in some embodiments, the effective amount of decal in the antimicrobial composition is 1000-1500 ppm.

[0202] In some embodiments, the effective amount of decal in the antimicrobial composition is 1000, or 1500, or 2000, or 2500, or 3000 ppm.

[0203] In some embodiments, the effective amount of pericolorle in the antimicrobial composition is 4000-6000 ppm. Alternatively, in some embodiments, the effective amount of pericolorle in the antimicrobial composition is 4500-6000 ppm. Alternatively, in some embodiments, the effective amount of pericolorle in the antimicrobial composition is 5000-6000 ppm. Alternatively, in some embodiments, the effective amount of pericolorle in the antimicrobial composition is 5500-6000 ppm.

[0204] Alternatively, in some embodiments, the effective amount of pericolorle in the antimicrobial composition is 4000-5500 ppm. Alternatively, in some embodiments, the effective amount of pericolorle in the antimicrobial composition is 4000-5000 ppm. Alternatively, in some embodiments, the effective amount of pericolorle in the antimicrobial composition is 4000-4500 ppm.

[0205] In some embodiments, the effective amount of pericolor in the antimicrobial composition is 4000, or 4500, or 5000, or 5500, or 6000 ppm.

[0206] In some embodiments, the composition further comprises at least one ingredient selected from the group consisting of perfume carriers, perfume co-ingredients, and mixtures thereof; and optionally at least one perfume adjuvant.

[0207] In some embodiments, the composition is formulated as a consumer product, wherein the consumer product is a fragrance, a fabric care product, a body care product, a cosmetic, a skin care product, an air care product, or a home care product. In one embodiment, the consumer product is a fine perfume, a splash or eau de parfum, a cologne, a shaving or aftershave lotion, a liquid or solid detergent, a fabric softener, a fabric refresher, an ironing solution, paper, a bleach, a carpet cleaner, a curtain care product, a shampoo, a color preparation, a color care product, a hair shaping product, a dental care product, a disinfectant, an intimate care product, a hairspray, a vanishing cream, a deodorant or antiperspirant, a depilatory, a tanning or sun care product, a nail product, a skin cleanser, a makeup product, a scented soap, a shower or bath mousse, an oil or gel, a foot / hand care product, a hygiene product, an air freshener, a "ready to use" powder air freshener, a mold remover, furniture care, a wipe, a dish detergent or hard surface cleaner, a leather care product, or a car care product.

[0208] By "perfume carrier" is meant a material that is substantially neutral from a perfume point of view, i.e., that does not appreciably alter the organoleptic properties of perfume ingredients. Carriers can be liquid or solid.

[0209] As the liquid carrier, non-limiting examples include emulsifying systems, i.e., systems of solvents and surfactants, or solvents commonly used in perfumery.The detailed description of the nature and type of solvents commonly used in perfumery cannot be exhaustive.However, non-limiting examples include solvents such as butylene or propylene glycol, glycerol, dipropylene glycol and its monoethers, 1,2,3-propanetriyl triacetate, dimethyl glutarate, dimethyl adipate, 1,3-diacetyloxypropan-2-yl acetate, diethyl phthalate, isopropyl myristate, benzyl benzoate, benzyl alcohol, 2-(2-ethoxyethoxy)-1-ethanoate, triethyl citrate or their mixtures, which are the most commonly used. For compositions containing both a perfume carrier and a perfume co-ingredient, suitable perfume carriers other than those previously specified may be ethanol, a water / ethanol mixture, limonene or other terpenes, isoparaffins such as those known under the trademark Isopar (supplied by Exxon Chemical) or glycol ethers and glycol ether esters such as those known under the trademark Dowanol (supplied by Dow Chemical Company), or hydrogenated castor oil such as those known under the trademark Cremophor RH 40 (supplied by BASF).

[0210] A solid carrier refers to a material that can chemically or physically bind a perfume composition or some components of the perfume composition. Generally, such solid carriers are used to stabilize the composition or to control the evaporation rate of the composition or some components. The use of solid carriers is currently used in the art, and those skilled in the art know how to achieve the desired effect. However, non-limiting examples of solid carriers include absorbent gums or polymers or inorganic materials, such as porous polymers, cyclodextrins, wood-based materials, organic or inorganic gels, clays, gypsum talc, or zeolites.

[0211] Other non-limiting examples of solid carriers can include encapsulation materials.Examples of such materials can include wall-forming materials and plasticizers such as monosaccharides, disaccharides or trisaccharides, natural or modified starches, hydrocolloids, cellulose derivatives, polyvinyl acetate, polyvinyl alcohol, proteins or pectins, or materials cited in references such as H. Scherz, Hydrokolloides: Stabilisatoren, Dickungs- und Geliermittel in Lebensmitteln, Band 2 der Schriftenreihe Lebensmittelchemie, Lebensmittelqualitaet, Behr's Verlag GmbH & Co., Hamburg, 1996.Encapsulation is a process well known to those skilled in the art, and can be carried out using techniques such as spray drying, agglomeration or extrusion; or consist of coating encapsulation, including coacervation and complex coacervation techniques. Non-limiting examples include core-cell encapsulation using techniques such as phase separation processes induced by polymerization, by interfacial polymerization, by coacervation, or all of these (all of which techniques are described in the prior art), and optionally in the presence of polymeric stabilizers or cationic polymers, with resins of the aminoplast, polyamide, polyester, polyurea, or polyurethane type (all of which resins are well known to those skilled in the art), or mixtures thereof.

[0212] In particular, the resins may be those prepared by polycondensation of aldehydes (such as formaldehyde, 2,2-dimethoxyethanal, glyoxal, glyoxylic acid or glycolaldehyde, and mixtures thereof) with amines, such as urea, benzoguanamine, glycoluril, melamine, methylolmelamine, methylated methylolmelamine, guanazole, and mixtures thereof. Alternatively, preformed resinous alkylolated polyamines may be used, such as those commercially available under the trademarks Urac® (supplied by Cytec Technology Corp.), Cymel® (supplied by Cytec Technology Corp.), Urecoll® or Luracoll® (supplied by BASF).

[0213] Mention may in particular be made of resins produced by polycondensation of polyols, such as glycerol, with polyisocyanates, such as the trimer of hexamethylene diisocyanate, the trimer of isophorone diisocyanate or xylylene diisocyanate, or the biuret of hexamethylene diisocyanate or the trimer of xylylene diisocyanate with trimethylolpropane (known under the trademark Takenate®, supplier: Mitsui Chemicals), among others the trimer of xylylene diisocyanate with trimethylolpropane and the biuret of hexamethylene diisocyanate.

[0214] Some of the seminal literature related to the encapsulation of perfumes by polycondensation of amino resins, i.e., melamine-based resins, with aldehydes, is represented by articles such as those published by K. Dietrich et al. in Acta Polymerica, 1989, Vol. 40, pages 243, 325, and 683, and 1990, Vol. 41, page 91. Such articles already describe the various parameters that affect the production of such core-shell microcapsules by prior art methods, which are further detailed and exemplified in the patent literature. U.S. Patent No. 4,396,670 to Wiggins Teape Group Limited is a good early example of the latter. Since then, many other authors or creators have enriched the literature in this field, so it is impossible to cover all the advances published here, but general knowledge of this type of encapsulation is extremely important. Relevant recent publications dealing with the appropriate use of such microcapsules are represented, for example, by H.Y. Lee et al. in Journal of Microencapsulation, 2002, vol. 19, pages 559-569, WO 01 / 41915 or by S. Bone et al. in Chimia, 2011, vol. 65, pages 177-181.

[0215] A perfume co-ingredient, when present in a perfume composition, is one other than nona-2,6-dien-1-ol, 3-neopentylpyridine, 2-methylhexan-3-one oxime, terpineol, or 2-isopropyl-5-methylphenol. Furthermore, the term "perfume co-ingredient" as used herein means a compound used in a perfume preparation or composition to impart a hedonic effect. In other words, it should be recognized by those skilled in the art that such a co-ingredient to be considered a perfume ingredient is not only one that has an odor, but also one that can impart or modify the odor of the composition in a positive or pleasant way.

[0216] The nature and type of perfumery co-ingredients do not warrant a more detailed description here, and in any case are not exhaustive; those skilled in the art can select them based on their general knowledge and according to the intended use or application and the desired organoleptic effect. In general terms, these perfumery co-ingredients belong to various chemical classes such as alcohols, lactones, aldehydes, ketones, esters, ethers, acetates, nitriles, terpenoids, nitrogen- or sulfur-containing heterocyclic compounds and essential oils, and they can be of natural or synthetic origin.

[0217] Mention may in particular be made of perfumery co-ingredients commonly used in perfume formulations such as: · Aldehydic components: decanal, dodecanal, 2-methyl-undecanal, 10-undecenal, octanal and / or nonenal; Aromatic herbal ingredients: eucalyptus oil, camphor, eucalyptol, menthol and / or alpha-pinene; · Balsam ingredients: coumarin, ethyl vanillin and / or vanillin; · Citrus ingredients: dihydromyrcenol, citral, orange oil, linalyl acetate, citronellyl nitrile, orange terpenes, limonene, 1-P-menthen-8-yl acetate and / or 1,4(8)-P-methandienes; Floral ingredients: Methyl dihydrojasmonate, linalool, citronellol, phenylethanol, 3-(4-tert-butylphenyl)-2-methylpropanal, hexyl cinnamaldehyde, benzyl acetate, benzyl salicylate, tetrahydro-2-isobutyl-4-methyl-4(2H)-pyranol, beta-ionone, methyl 2-(methylamino)benzoate, (E)-3-methyl-4-(2,6,6-trimethyl-2-cyclohexen-1-yl)-3-buten-2-one, hexyl salicylate, 3,7-dimethyl-1,6-nonadien-3-ol, 3-(4-isopropylphenyl)-2-methylpropanal, verdyl acetate acetate), geraniol, p-mentha-1-en-8-ol, 4-(1,1-dimethylethyl)-1-cyclohexyl acetate, 1,1-dimethyl-2-phenylethyl acetate, 4-cyclohexyl-2-methyl-2-butanol, amyl salicylate, high-cis methyl dihydrojasmonate, 3-methyl-5-phenyl-1-pentanol, verdyl propionate proprionate), geranyl acetate, tetrahydrolinalool, cis-7-p-menthanol, propyl (S)-2-(1,1-dimethylpropoxy)propanoate, 2-methoxynaphthalene, 2,2,2-trichloro-1-phenylethyl acetate, 4 / 3-(4-hydroxy-4-methylpentyl)-3-cyclohexene-1-carbaldehyde, amyl cinnamaldehyde, 4-phenyl-2-butanone, isononyl acetate, 4-(1,1-dimethylethyl)-1-cyclohexyl acetate, verdyl isobutyrate and / or a mixture of methyl ionone isomers; · Fruity ingredients: Gamma Ungamma-Dodecalactone Acetone, 4-Decanolide, Ethyl 2-Methyl-Pentanoate, Hexyl Acetate, Ethyl 2-Methylbutanoate, γ-Nonalactone, Allylheptanoate, 2-Phenoxyethyl Isobutyrate, Ethyl 2-Methyl-1,3-Dioxolane-2-Acetate and / or Diethyl 1,4-Cyclohexanedicarboxylate; · Green ingredients: 2,4-dimethyl-3-cyclohexene-1-carbaldehyde, 2-tert-butyl-1-cyclohexyl acetate, styryl acetate, allyl (2-methylbutoxy) acetate, 4-methyl-3-decen-5-ol, diphenyl ether, (Z)-3-hexen-1-ol and / or 1-(5,5-dimethyl-1-cyclohexen-1-yl)-4-penten-1-one; Musk ingredients: 1,4-dioxa-5,17-cyclopentadecanedione, pentadecenolide, 3-methyl-5-cyclopentadecen-1-one, 1,3,4,6,7,8-hexahydro-4,6,6,7,8,8-hexamethyl-cyclopenta-g-2-benzopyran, (1S,1′R)-2-[1-(3′,3′-dimethyl-1′-cyclohexyl)ethoxy]-2-methylpropylpropanoate, pentadecanolide and / or (1S,1′R)-[1-(3′,3′-dimethyl-1′-cyclohexyl)ethoxycarbonyl]methylpropanoate; Woody ingredients: 1-(octahydro-2,3,8,8-tetramethyl-2-naphthalenyl)-1-ethanone, patchouli oil, terpene fraction of patchouli oil, (1′R,E)-2-ethyl-4-(2′,2′,3′-trimethyl-3′-cyclopenten-1′-yl)-2-buten-1-ol, 2-ethyl-4-(2,2,3-trimethyl-3-cyclopenten-1-yl)-2-buten-1-ol, methyl cedryl ketone, 5-(2,2,3-trimethyl-3-cyclopentenyl)-3-methylpentan-2-ol, 1-(2,3,8,8-tetramethyl-1,2,3,4,6,7,8,8a-octahydronaphthalen-2-yl)ethan-1-one and / or isobornyl acetate; Other ingredients (e.g., amber, powdery spicy, or watery): dodecahydro-3a,6,6,9a-tetramethyl-naphtho[2,1-b]furan and any stereoisomers thereof, heliotropin, anisaldehyde, eugenol, cinnamaldehyde, clove oil, 3-(1,3-benzodioxol-5-yl)-2-methylpropanal, and / or 3-(3-isopropyl-1-phenyl)butanal.

[0218] Perfume co-ingredients are not limited to those mentioned above, and many other co-ingredients are listed in any case in reference works such as the book by S. Arctander, Perfume and Flavor Chemicals, 1969, Montclair, New Jersey, USA, or its more recent editions, or other works of a similar nature, as well as in the abundant patent literature in the field of perfumery. It is understood that the co-ingredients may also be compounds known to provide controlled release of various types of perfume compounds.

[0219] By "perfuming adjuvant" is meant an ingredient capable of imparting additional benefits such as color, especially lightfastness, chemical stability, etc. A detailed description of the nature and type of adjuvants commonly used in perfumery cannot be exhaustive, but it must be mentioned that these ingredients are well known to those skilled in the art. However, specific, non-limiting examples may include: viscosity modifiers (e.g., surfactants, thickeners, gelling agents and / or rheology modifiers), stabilizers (e.g., preservatives, antioxidants, heat / light and / or buffers or chelating agents, e.g., BHT), colorants (e.g., dyes and / or pigments), preservatives (e.g., antibacterial or antimicrobial or antifungal or anti-irritant agents), abrasives, skin cooling agents, fixatives, insect repellents, ointments, vitamins, and mixtures thereof.

[0220] It is understood that a person skilled in the art can fully design an optimum formulation for a desired effect by simply applying standard knowledge in the art as well as by trial and error methodology by mixing the above-mentioned components of the fragrance composition.

[0221] The fragrance composition comprises at least one antimicrobial composition as defined above and at least one perfume carrier representing a particular embodiment of this disclosure, as well as the fragrance composition comprises at least one antimicrobial composition as defined above, at least one perfume carrier, at least one perfume co-ingredient, and optionally at least one perfume adjuvant.

[0222] For clarity, it is understood that any mixture resulting directly from chemical synthesis, e.g., a reaction medium that would contain a compound of the present disclosure as a starting material, intermediate, or final product without appropriate purification, cannot be considered a fragrance composition according to the present disclosure, unless the mixture provides the compound of the present invention in a form suitable for fragrance. Thus, unpurified reaction mixtures are generally excluded from the present disclosure, unless expressly stated otherwise.

[0223] Furthermore, the antimicrobial compositions as defined above can also be advantageously used in all areas of modern perfumery, i.e. fine perfumes or functional perfumery, to positively impart or modify the odor of consumer products to which they are added. Another subject of the present disclosure is therefore represented by perfumed consumer products comprising at least one antimicrobial composition as described herein.

[0224] The above-described compositions can be added as is or as part of the fragrance composition of the present disclosure.

[0225] For clarity, it should be noted that "perfumed consumer product" refers to a consumer product that is expected to provide at least a pleasant perfume effect to the surface (e.g., skin, hair, textile, or residential surface) or air to which it is applied. In other words, a perfumed consumer product according to the present disclosure is a perfumed consumer product that includes a functional formulation, and optionally an additional benefit agent corresponding to a desired consumer product, such as a detergent or air freshener, and an olfactory-effective amount of at least one compound of the present disclosure. For clarity, a perfumed consumer product is a non-edible product.

[0226] The nature and type of constituents of perfume consumer products does not warrant a more detailed description here, which is in any case not exhaustive, and the skilled person can select said constituents on the basis of general knowledge and according to the nature of the product and the desired effect.

[0227] Non-limiting examples of suitable perfume consumer products include fragrances such as fine perfumes, splashes or eau de parfums, colognes or shave or aftershave lotions; fabric care products such as liquid or solid detergents, fabric softeners, fabric refreshers, ironing water, paper or bleach, carpet cleaners, curtain care products; body care products such as hair care products (e.g. shampoos, coloring preparations or hairsprays, color care products, hair shaping products, dental care products), disinfectants, intimate care products; cosmetics (e.g. skin creams or lotions, vanishing creams or deodorants or antiperspirants (e.g. sprays or roll-ons), depilatories, tanning or tanning or after-sun products, nail products, skin cleansing, makeup; or skin care products (e.g., perfumed soaps, shower or bath smoothies, oils or gels, or hygiene or foot / hand care products); air care products such as air fresheners or "ready-to-use" powder air fresheners that can be used in residential spaces (rooms, refrigerators, cupboards, shoes, or cars) and / or public spaces (hallways, hotels, malls, etc.); or home care products such as mold removers, furniture care, wipes, dish detergents, or hard surface (e.g., floor, bath, toilet, or window) cleaners; leather care products; car care products such as polishes, waxes, plastic cleaners. Alternatively, in some embodiments, the consumer product is a body care product or a home care product.

[0228] Some of the aforementioned perfume consumer products may represent an aggressive medium for the compositions of the present disclosure, and it may be necessary to protect the latter compositions from premature degradation, for example, by encapsulation or chemical bonding to other chemical agents suitable for releasing the ingredients of the present disclosure in response to an appropriate external stimulus such as enzymes, light, heat or pH change.

[0229] The proportions at which the compositions according to the present disclosure can be incorporated into the various products or compositions mentioned above vary within wide ranges, depending on the nature of the article to be perfumed and the desired organoleptic effect, as well as, if the compounds according to the present disclosure are mixed with perfume co-ingredients, solvents or additives commonly used in the art, the nature of the co-ingredients.

[0230] For example, in the case of fragrance compositions, typical concentrations are on the order of 0.001% to 10% by weight, or more, of the compositions of the present disclosure, based on the weight of the composition they are incorporated into. Lower concentrations, such as on the order of 0.01% to 1% by weight, can be used when these compounds are incorporated into perfume consumer products, as a percentage of the weight of the article.

[0231] In some aspects, the present disclosure provides methods of use, including the inhibition of microbial activity, particularly in fragrances or consumer products, by avoiding the presence of chlorinated biocides in such products. These methods include adding or incorporating an antimicrobial composition as described herein into such products, where the antimicrobial composition provides an antimicrobial effect. Thus, the use of chlorinated biocides can be avoided or eliminated.

[0232] The present invention is best illustrated by the following examples, but is not limited thereto.

[0233] Example Example 1: Preparation of bacterial suspension and BCT test C. xerosis:A suspension of C. xerosis ATCC 373 strain was prepared as follows: a stock culture (stored at -80°C) was thawed, subcultured onto tryptic soy agar with 0.5% Tween 80 (TSA-TW80), and incubated at 37°C for 48 h. The primary culture was again subcultured onto TSA-TW80 to prepare a secondary culture. A single colony from the secondary culture was selected and used to inoculate 30 ml of brain heart infusion broth with 0.5% Tween 80 (BHI-TW80). The inoculated broth was incubated at 37°C and 180 rpm for 24 h. An aliquot (1 ml) of the 24-h culture was inoculated into 30 ml of fresh BHI-TW80 broth and incubated at 37°C and 180 rpm for 48 h. Aliquots (2–3 ml) of the 48-h culture were inoculated into four 50-ml portions of fresh BHI-TW80 broth medium and incubated at 37°C and 180 rpm for 4–6 h. OD 600nm When the NA reaches a target value of 1.6, cells are harvested by centrifugation at 5000 rpm for 10 min and then centrifuged at 10 9 ~10 10 The bacteria were resuspended in the same fresh BHI-TW80 at a concentration of 1000 cfu / mL. This suspension was used as the bacterial suspension for the BCT test.

[0234] S. haemolyticus: A suspension of S. haemolyticus strain 114126 isolated from skin was prepared as follows: a stock culture (stored at -80°C) was thawed, subcultured onto TSA-TW80 agar plates, and incubated at 37°C for 24 h to obtain single colonies. A single colony from the primary culture was streaked onto a new TSA-TW80 plate and incubated at 37°C for 24 h to prepare a secondary culture. A single colony from the secondary culture was picked and used to inoculate 50 mL of BHI-TW80 broth. The inoculated broth was incubated at 37°C and 180 rpm for 18 h. An aliquot (0.5 ml) of the 18-h culture was inoculated into 50 ml of fresh BHI-TW80 broth and incubated at 37°C and 180 rpm for approximately 3 h. The OD of the broth was 0.5 ml. 600nmWhen the value reached 1–2, cells were harvested by centrifugation at 5000 rpm for 10 min and then diluted with 1–5 × 10 8 The bacteria were resuspended in fresh BHI-TW80 broth at a concentration of 100 CFU / mL. This suspension was used as the bacterial suspension for the BCT test.

[0235] E. coli, S. aureus, P. aeruginosa, and S. enterica: Individual suspensions of E. coli ATCC 10536, S. aureus ATCC 6538, Pseudomonas aeruginosa ATCC 15442, and Salmonella enterica ATCC 10708 were prepared as follows: stock cultures (stored at -80°C) were thawed, subcultured onto tryptic soy agar (TSA) plates, and incubated at 37°C for 24 h to obtain single colonies. A single colony from the primary culture was streaked onto a TSA plate and incubated at 37°C for 24 h to generate a secondary culture. A single colony from the secondary culture was picked and used to inoculate 50 mL of TSB broth. The inoculated TSB broth was incubated at 37°C at 180 rpm for 18 h. An aliquot (0.5 ml) of the 18-h culture was inoculated into 50 ml of fresh TSB broth and incubated at 37°C and 180 rpm for 2–3 h. The OD of the broth was 600nm When the value reached 1–2, cells were harvested by centrifugation at 5000 rpm for 10 min and then diluted with 1–5 × 10 8 The bacteria were resuspended in fresh TSB broth at a concentration of 100 CFU / mL. These suspensions were used as bacterial suspensions for the BCT test.

[0236] BCT Test: A range of concentrations of test compositions (combinations of more than one fragrance ingredient and comparative compositions containing a single fragrance ingredient) were prepared in ethanol. Five replicates of each test composition were added (120 μl per well) to a 96-well microtiter plate, with row B containing a control composition containing only ethanol solution. Approximately 1×10 per mL 8120 μl of bacterial cell suspension (prepared above) with a bacterial concentration of 0.01 was added to each well of a microtiter plate. The bacterial suspension was incubated with the test solution for 45, 60, or 120 seconds. Following incubation of the bacterial suspension with the test solution, serial dilutions of the bacterial suspension (three 1:10 dilutions, followed by seventeen 1:2 dilutions) were made within the multi-well microtiter plate.

[0237] Each plate was sealed and incubated at 37°C with agitation (180 rpm). After incubation, the turbidity (OD 600nm ) was determined using a Tecan microplate reader. Turbid wells were considered positive growth due to the presence of viable cells. The total number of viable cells (log CFU) for each sample was calculated. The log reduction value for each test composition at the final concentration (dose) was calculated relative to the ethanol solution control sample. The magnitude of the effect (f) observed from a particular concentration of the test composition was calculated. a ) was calculated by dividing the log reduction value of each sample by the log CFU value of the control sample (referred to here as the efficacy factor).

[0238] Determination of synergy by combination index (CI): CIs were calculated using Compusyn software (ComboSyn, Inc., written by Dr. Dorothy Chou in 2005) according to the manufacturer's instructions. The concentration of each test composition (combinations of more than one fragrance ingredient, and comparison compositions having a single fragrance ingredient used to generate the combination) and its corresponding effect factor were entered, and the corresponding CI was calculated.

[0239] If the calculated CI value was less than 0.9, the combination of perfume ingredients was considered to have a synergistic effect. If the calculated CI value was between 1.0 and 0.9, the combination of perfume ingredients was considered to have an additive effect. If the calculated CI value was greater than 1.0, the combination of perfume ingredients was considered to have an antagonistic effect.

[0240] Tables 1-53 show the dosage effects of compositions according to various embodiments described herein and of the corresponding individual fragrance ingredients on bacterial cell inactivation. Composition stocks were prepared in 100% ethanol and then diluted with MilliQ water to obtain 2x final concentrations in 40% or 50% ethanol. These experiments were designed with a variety of target strains and contact times to reflect a variety of applications: deodorants (Tables 1-14); soaps (Tables 15-24); and surface cleaners (Tables 25-53).

[0241] Tables 54-56 show the log reduction values ​​and calculated CIs of the tested compositions against various strains for various applications using the data in Tables 1-53. Highlighted cells indicate the calculated synergistic effect of a particular combination of perfume ingredients. The following table summarizes the data in Tables 54-56 and lists various synergistic compositions produced according to several embodiments presented herein. [Table 2]

[0242] The following table describes the perfume ingredients (PRM) that make up compositions A3, A4, S1, S2, S5, S11, S12, and S15 at specific concentrations and lists the amount of perfume ingredient in the composition in ppm. [Table 3-1] [Table 3-2] Example 2: In vitro efficacy of compositions according to some embodiments presented herein in a roll-on deodorant base

[0243] Test deodorant formulations containing any of the antimicrobial compositions A3, A4, S2, S5, S12, S14, and S15 were prepared as follows: 50 mg of the antimicrobial composition was added to 300 mg of Cremphor (BASF) and 9.57 g of deodorant base. The combined mixture was stirred for 10 minutes using a magnetic stirrer. Control deodorant formulations were also prepared containing either the deodorant base without the antimicrobial composition or ethylhexylglycerin.

[0244] A 900 g sample of the test or control deodorant formulation was added to a suspension of C. xerosis ATCC 373 cells prepared according to the method described in Example 1 above. The test and control deodorant formulations were allowed to contact the bacterial suspension for 120 seconds, during which time the samples were mixed as follows: 2x (vortex mixed for 30 seconds, then allowed to settle for 10 seconds), then mixed again for 20 seconds. At the completion of the contact time, a 9 ml aliquot of brain heart infusion broth (BHI) was added to each sample, and 10 ml of the sample was mixed. -1 Dilutions were made. Further dilutions (10 -2 ~10 -7 ) was performed in 900 μl of BHI. Aliquots (100 μl) of each dilution were plated on duplicate plates in TSA + 0.5% Tween 80 medium. After 3 days of incubation at 37°C, colonies on the plates were counted. The log reduction in viable cells was calculated relative to the control sample in BHI medium. The results are shown in Figure 1.

[0245] Test deodorant formulations containing any of antimicrobial compositions A3, A4, S2, S5, S12, S14, and S15 demonstrated greater log reductions in bacterial growth than both control deodorant formulations containing the benchmark antimicrobial agent ethylhexylglycerin (lower and upper lines, respectively, in Figure 1). Example 3: In vivo effects of the composition designated "A4" in a deodorant base

[0246] Next, antimicrobial composition A4 was selected and incorporated into a roll-on deodorant base by the method described in Example 2. Referring to the table below, antimicrobial composition A4 was selected as the prototype for the roll-on product because it contains ingredients such as heliopropanal and phenylhexanol, which have a low evaporation rate. A low evaporation rate can prolong the antimicrobial activity of the deodorant formulation. [Table 4]

[0247] Subjects were asked to rate the test deodorant formulations' ability to reduce sweat malodor 4 and 8 hours after application. Additionally, the test deodorant formulations' ability to reduce bacterial populations on the subjects' skin was also evaluated.

[0248] Efficacy assessment 4 hours after application: Referring to the table below, 40 subjects followed the following protocol: For the first 6 days of the study, subjects were instructed to use unscented soap for cleansing and to refrain from using deodorants and antiperspirants. After this initial 6-day washout period, subjects performed a standardized wash of the armpits with unscented soap. 24 hours after the wash, four smell evaluators evaluated sweat odor to qualify 20 subjects. The next day, the 20 eligible subjects performed another standardized wash. The sweat odor assessment was repeated, and microbial swabs were taken for the 0-hour assessment (baseline). Then, the test deodorant formulation (400 mg) was randomly applied to one armpit per subject. Four hours after product application, the sweat odor assessment was repeated, and microbial swabs were again taken from both armpits. The results are shown in Figure 2. [Table 5]

[0249] Referring to Figure 2, no significant differences were observed between treated and untreated axillae at baseline time 0 (p>0.05). However, after 4 hours, treated axillae had significantly lower reported malodor values, total bacterial counts, and corynebacterial counts (p<0.05). Taken together, these data suggest that the test deodorant formulations were able to control sweat malodor.

[0250] Efficacy assessment 8 hours after application: Referring to the table below, 40 subjects followed the following protocol: For the first 7 days of the study, subjects were instructed to use unscented soap for cleansing and to refrain from using deodorants and antiperspirants. After this initial 6-day washout period, subjects performed a standardized wash of the armpits with unscented soap. 24 hours after cleansing, four smell evaluators evaluated sweat odor to confirm the validity of 20 subjects. The next day, the subjects performed another standardized wash. The sweat odor assessment was repeated, and a microbial swab was taken for the 0-hour assessment (baseline). Then, the test deodorant formulation (400 mg) was randomly applied to one armpit per subject. Eight hours after product application, the sweat odor assessment was repeated, and a microbial swab was again taken from both armpits. The results are shown in Figure 3. [Table 6]

[0251] Referring to Figure 3, no significant differences were observed between treated and untreated axillae at baseline time 0 (p>0.05). However, after 8 hours, treated axillae had significantly lower reported malodor values, total bacterial counts, and corynebacterial counts (p<0.05). Taken together, these data suggest that the test deodorant formulations were able to control sweat malodor. [Table 7] [Table 8]

Table 9

Table 10

Table 11

Table 12

Table 13

Table 14

Table 15

Table 18

Table 30

[0252]

[0010] While various aspects of the present invention have been described above with reference to examples and preferred embodiments, it will be recognized that the scope of the present invention is not to be defined by the foregoing description, but rather by the following claims, appropriately interpreted in accordance with the principles of patent law.

Claims

1. Use of a composition comprising fragrance ingredients consisting of heliopropanal, nerol, phenylhexanol, and 3,7-dimethyl-3-octanol in a consumer product selected from the group consisting of fragrances, fabric care products, body care products, cosmetics, skin care products, air care products, and home care products, comprising: The perfume ingredient is present in the composition in an amount of 0.05 to 0.5% w / v.

2. 2. The use according to claim 1, wherein the ratio of heliopropanal, nerol, phenylhexanol, and 3,7-dimethyl-3-octanol is 6:3:5:

6.

3. 10. The use according to claim 1, wherein the composition further comprises at least one ingredient selected from the group consisting of perfume carriers, perfume co-ingredients, and mixtures thereof, and optionally at least one perfume adjuvant.

4. 2. The use according to claim 1, wherein the consumer product is selected from the group consisting of fine perfumes, splash or eau de parfums, colognes, shaving or aftershave lotions, liquid or solid detergents, fabric softeners, fabric refreshers, ironing water, paper, bleach, carpet cleaners, curtain care products, shampoos, colour preparations, colour care products, hair shaping products, dental care products, disinfectants, intimate care products, hairsprays, vanishing creams, deodorants or antiperspirants, depilatories, tanning or suntanning products, nail products, skin cleansing, make-up, scented soaps, shower or bath mousses, oils or gels, or foot / hand care products, hygiene products, air fresheners, "ready to use" powder air fresheners, mould removers, furniture care, wipes, dishwashing or hard surface cleaners, leather care products, car care products.

5. The use of claim 1 , wherein the composition provides an antibacterial effect through the inactivation of bacterial cells.

6. 6. The use according to claim 5, wherein the antibacterial effect is the inhibition of the growth of a bacterial strain selected from the group consisting of Corynebacterium xerosis, Pseudomonas aeruginosa, Salmonella enterica, Staphylococcus haemolyticus, Staphylococcus aureus and Escherichia coli.

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