Blood purification device

Abstract

To confirm that air is not entering a measuring bag during priming while suppressing an increase in the number of components by not installing a pressure sensor in the measuring bag.SOLUTION: A control unit executes a first step S1 for closing a vein side on-off valve while operating a replacement fluid pump during priming in which priming fluid is supplied to an artery side blood circuit, a blood purifier, and a vein side blood circuit from a priming fluid pipeline, executes a second step S2 for determining whether or not an amount of increase in an artery side measurement value or a vein side measurement value after the vein side on-off valve is closed in the first step S1 exceeds a threshold within a fixed time, executes the first step S1 again after executing a fourth step S4 for temporarily opening the vein side on-off valve when the amount of increase in the artery side measurement value or the vein side measurement value exceeds the threshold in the second step S2, and executes a third step S3 for stopping the replacement fluid pump when the amount of increase in the artery side measurement value or the vein side measurement value is the threshold or less in the second step S2.SELECTED DRAWING: Figure 3

Description

[Technical Field]

[0001] The present invention relates to a blood purification device. [Background technology]

[0002] Japanese Patent Application Laid-Open No. 2018-94051 (Patent Document 1) is a prior art document that discloses a method for checking for incorrect installation of a partial volume measuring chamber in a blood purification device. The blood purification device described in Patent Document 1 performs the steps of applying positive or negative pressure to the measuring chamber and checking whether the measuring chamber is installed in the correct position by detecting a decrease or increase in pressure using a pressure sensor connected to the measuring chamber. [Prior art documents] [Patent documents]

[0003] [Patent Document 1] Japanese Patent Application Publication No. 2018-94051 Summary of the Invention [Problem to be solved by the invention]

[0004] If a pressure sensor is installed in each measuring chamber, the number of parts in the blood purification device increases. Furthermore, if the measuring chambers are configured with measuring bags that do not have air vent holes, the specified amount of fluid may not be stored in the measuring bag if air is present inside the measuring bag. The amount of air in the measuring bag cannot be determined from the weight measurement of the measuring bag.

[0005] The present invention has been made in consideration of the above problems, and has an object to provide a blood purification device that can confirm that no air has entered the weighing bag during priming, while suppressing an increase in the number of parts by not providing a pressure sensor on the weighing bag. [Means for solving the problem]

[0006] A blood purification apparatus according to the present invention comprises a blood purifier, an arterial blood circuit, a venous blood circuit, a replacement fluid line, a dialysate line, a drain line, a blood pump, an arterial air trap chamber, an arterial on-off valve, a venous air trap chamber, a venous on-off valve, a priming fluid line, a replacement fluid pump, a dialysate pump, a drain pump, a first measuring bag, a scale, an arterial pressure measuring device, a venous pressure measuring device, and a controller. The arterial blood circuit is connected to the blood purifier and is provided to allow blood to flow into the blood purifier. The venous blood circuit is connected to the blood purifier and is provided to allow blood to flow out of the blood purifier. The replacement fluid line is connected to the arterial blood circuit or the venous blood circuit and supplies replacement fluid. The dialysate line supplies dialysate to the blood purifier. The drain line carries drained fluid discharged from the blood purifier. The blood pump is provided in the arterial blood circuit and pumps blood. The arterial air trap chamber is provided in the arterial blood circuit. The arterial on-off valve is provided in the arterial blood circuit and opens and closes the arterial blood circuit. The venous air trap chamber is provided in the venous blood circuit. The venous on-off valve is provided in the venous blood circuit and opens and closes the venous blood circuit. The priming solution line is connected to the arterial blood circuit between the arterial on-off valve and the blood pump and supplies priming solution. The replacement solution pump is provided in the replacement solution line and delivers replacement solution. The dialysate pump is provided in the dialysate line and delivers dialysate. The drainage pump is provided in the drainage line and delivers drained solution. The first measuring bag is connected to the replacement solution line and can temporarily store replacement solution and deliver the stored replacement solution. The scale can measure changes in weight of the first measuring bag. The arterial pressure measuring device measures the pressure in the arterial air trap chamber. The venous pressure measuring device measures the pressure in the venous air trap chamber. The control unit receives an arterial measurement value measured by the arterial pressure measuring device or a venous measurement value measured by the venous pressure measuring device.The control unit performs a first step of closing the venous on-off valve while operating the fluid replacement pump during priming in which priming solution is supplied from the priming solution pipe to the arterial blood circuit, the blood purifier, and the venous blood circuit, a second step of determining whether an increase in the arterial side measurement value or the venous side measurement value after the venous side on-off valve is closed in the first step exceeds a threshold value within a certain period of time, a fourth step of temporarily opening the venous side on-off valve if the increase in the arterial side measurement value or the venous side measurement value exceeds the threshold value in the second step, and then performs the first step again, and a third step of stopping the fluid replacement pump if the increase in the arterial side measurement value or the venous side measurement value is equal to or less than the threshold value in the second step.

[0007] In one embodiment of the present invention, the fluid replacement line is connected to the venous blood circuit, and the venous measurement value is input to a control unit. The control unit performs a second step of determining whether an increase in the venous measurement value after the venous on-off valve is closed in the first step exceeds the threshold within a certain period of time, and if the increase in the venous measurement value exceeds the threshold in the second step, performs a fourth step of temporarily opening the venous on-off valve, and then performs the first step again. If the increase in the venous measurement value is equal to or less than the threshold in the second step, the control unit performs a third step of stopping the fluid replacement pump.

[0008] In one embodiment of the present invention, the fluid replacement line is connected to the arterial blood circuit. The arterial measurement value is input to a control unit. The control unit performs a second step of determining whether an increase in the arterial measurement value after the venous on-off valve is closed in the first step exceeds the threshold value within a certain period of time. If the increase in the arterial measurement value exceeds the threshold value in the second step, the control unit performs a fourth step of temporarily opening the venous on-off valve, and then performs the first step again. If the increase in the arterial measurement value is equal to or less than the threshold value in the second step, the control unit performs a third step of stopping the fluid replacement pump.

[0009] In one embodiment of the present invention, the blood purification apparatus further includes a second weighing bag. The second weighing bag is connected to a drainage line, temporarily stores the drained fluid, and is capable of discharging the stored drained fluid. The scale measures the total weight change of the first weighing bag and the second weighing bag.

[0010] In one embodiment of the present invention, the threshold value is 600 Pa or more and 700 Pa or less. [Effects of the Invention]

[0011] According to the present invention, by not providing a pressure sensor on the measuring bag, it is possible to suppress an increase in the number of parts of the blood purification device, while also making it possible to confirm during priming that no air has entered the measuring bag. [Brief explanation of the drawings]

[0012] [Figure 1] 1 is a circuit diagram showing the configuration of a blood purification device according to Embodiment 1 of the present invention. [Figure 2] FIG. 2 is a block diagram showing the electrical connection relationship between the control unit and each component in the blood purification apparatus according to the first embodiment of the present invention. [Figure 3] 1 is a flowchart showing the operation for confirming that no air has entered the first measuring bag during priming in the blood purification apparatus according to the first embodiment of the present invention. [Figure 4] FIG. 4 is a circuit diagram showing the configuration of a blood purification device according to a second embodiment of the present invention. [Figure 5] 10 is a flowchart showing the operation for confirming that no air has entered the first measuring bag during priming in the blood purification apparatus according to the second embodiment of the present invention. DETAILED DESCRIPTION OF THE INVENTION

[0013] Hereinafter, blood purification devices according to various embodiments of the present invention will be described with reference to the drawings. In the following description of the embodiments, the same or corresponding parts in the drawings will be designated by the same reference numerals, and description thereof will not be repeated.

[0014] In the following description of the embodiments, a blood purification device used in continuous renal replacement therapy (CRRT) will be described. However, the blood purification device may also be a blood purification device used in any of continuous hemodiafiltration (CHDF), continuous hemofiltration (CHF), and continuous hemodialysis (CHD).

[0015] (Embodiment 1) Fig. 1 is a circuit diagram showing the configuration of a blood purification apparatus according to Embodiment 1 of the present invention. As shown in Fig. 1, the blood purification apparatus 100 according to Embodiment 1 of the present invention includes a blood purifier 120, an arterial blood circuit 110, a venous blood circuit 116, a replacement fluid line 131, a dialysate line 141, a drainage line 151, a blood pump 111, an arterial air trap chamber 112, an arterial on-off valve 110v, a venous air trap chamber 114, a venous on-off valve 116v, a priming fluid line 191, a replacement fluid pump 161, a dialysate pump 160, a drainage pump 162, a first measuring bag 140, a scale 180, an arterial pressure measuring device 113, a venous pressure measuring device 115, and a controller.

[0016] The blood purification apparatus 100 further includes a first supply source 130, a priming solution supply source 190, a first connecting line 132, a second connecting line 152, an arterial supply / exhaust line 117, a venous supply / exhaust line 118, a second measuring bag 150, a first valve 141v, a second valve 131v, a third valve 151v, a fourth valve 152v, a fifth valve 191v, a sixth valve 117v, a seventh valve 118v, an arterial protective filter 117f, a venous protective filter 118f, a first heater 170, and a second heater 171.

[0017] The blood purifier 120 contains a semipermeable membrane, such as a hollow fiber membrane. The blood purifier 120 has a blood inlet 121 and a blood outlet 122. The arterial blood circuit 110 is connected to the blood inlet 121. The venous blood circuit 116 is connected to the blood outlet 122.

[0018] The arterial blood circuit 110 is provided with a blood pump 111 that pumps blood. In the arterial blood circuit 110, an arterial air trap chamber 112 is provided between the blood pump 111 and the blood purifier 120. The arterial air trap chamber 112 is provided with an arterial pressure measuring device 113 that measures the pressure inside the arterial air trap chamber 112. An arterial protective filter 117f is provided between the arterial air trap chamber 112 and the arterial pressure measuring device 113. The arterial blood circuit 110 is provided with an arterial on-off valve 110v that opens and closes the arterial blood circuit 110.

[0019] Blood collected from a patient's artery flows through the arterial blood circuit 110, has its pressure measured as it passes through the arterial air trap chamber 112, and then flows into the blood purifier 120 from the blood inlet 121. The arterial air trap chamber 112 is provided to prevent air from mixing with the blood in the arterial blood circuit 110.

[0020] The venous blood circuit 116 is provided with a venous air trap chamber 114. The venous air trap chamber 114 is provided with a venous pressure measuring device 115 that measures the pressure inside the venous air trap chamber 114. A venous protective filter 118f is provided between the venous air trap chamber 114 and the venous pressure measuring device 115. The venous blood circuit 116 is provided with a venous on-off valve 116v that opens and closes the venous blood circuit 116.

[0021] The blood purified by the blood purifier 120 flows through the venous blood circuit 116, has its pressure measured as it passes through the venous air trap chamber 114, and is then returned to the patient's veins. The venous air trap chamber 114 is provided to prevent air from mixing with the blood in the venous blood circuit 116.

[0022] The blood purifier 120 further has a dialysate inlet 124 and a waste fluid outlet 123. A dialysate line 141 is connected to the dialysate inlet 124. A waste fluid line 151 is connected to the waste fluid outlet 123.

[0023] The upstream end of the dialysate conduit 141 is connected to a first supply source 130 that supplies a first fluid 10, which is a replacement fluid and a dialysate. The dialysate conduit 141 is connected to the upstream end of the replacement fluid conduit 131. A dialysate pump 160 that pumps the dialysate is connected to the dialysate conduit 141. The dialysate pump 160 is a peristaltic pump, but may be a roller pump. The dialysate that flows through the dialysate conduit 141 is supplied into the blood purifier 120. A first valve 141v that opens and closes the dialysate conduit 141 is provided upstream of the connection point with the replacement fluid conduit 131 in the dialysate conduit 141. A first heater 170 that heats the dialysate is provided downstream of the dialysate pump 160 in the dialysate conduit 141. Note that the first heater 170 does not necessarily have to be provided.

[0024] A replacement fluid pump 161 that pumps replacement fluid is connected to the replacement fluid line 131. The replacement fluid pump 161 is a peristaltic pump, but may also be a roller pump. A first connecting line 132 through which the first fluid 10 flows is connected to the replacement fluid line 131. A second valve 131v that opens and closes the replacement fluid line 131 is provided upstream of the connection position of the replacement fluid line 131 with the first connecting line 132. A second heater 171 that heats the replacement fluid is provided downstream of the replacement fluid pump 161 in the replacement fluid line 131. Note that the second heater 171 does not necessarily have to be provided.

[0025] In this embodiment, the fluid replacement line 131 is connected to the venous blood circuit 116. Specifically, the fluid replacement line 131 is connected to the venous air trap chamber 114. The fluid replacement line 131 flows into the venous air trap chamber 114. That is, the fluid replacement line 131 supplies the fluid replacement to the venous blood circuit 116. The blood purification device 100 employs a so-called post-dilution method.

[0026] The first connecting pipeline 132 is connected to a first measuring bag 140 that temporarily stores the first liquid 10 and is capable of discharging the stored first liquid 10.

[0027] The drainage pipe 151 discharges the drainage liquid discharged from the blood purifier 120 from the downstream end thereof. A drainage pump 162 is connected to the drainage pipe 151, and sends out the drainage liquid flowing through the drainage pipe 151. The drainage pump 162 is a peristaltic pump, but may also be a roller pump. A second connection pipe 152 through which the drainage liquid flows is connected to the drainage pipe 151. A third valve 151v that opens and closes the drainage pipe 151 is provided in the drainage pipe 151.

[0028] The second connecting pipe 152 is connected to a second measuring bag 150 that temporarily stores the effluent and can discharge the stored effluent. The second connecting pipe 152 is provided with a fourth valve 152v that opens and closes the second connecting pipe 152.

[0029] The first weighing bag 140 and the second weighing bag 150 are housed in the housing portion 181. Each of the first weighing bag 140 and the second weighing bag 150 is a soft bag that does not have any air vent holes formed therein.

[0030] The storage section 181 is connected to a measurement section of the scale 180. In this embodiment, the scale 180 is a load cell. However, the scale 180 is not limited to a load cell and may be a spring balance or the like. The scale 180 measures the overall change in weight of the first weighing bag 140 and the second weighing bag 150. When the fourth valve 152v closes the second connecting conduit 152, the scale 180 can measure the change in weight of the first weighing bag 140.

[0031] The priming solution line 191 is connected between the arterial on-off valve 110v and the blood pump 111 in the arterial blood circuit 110, and supplies the priming solution 20. The priming solution line 191 is provided with a fifth valve 191v that opens and closes the priming solution line 191. The priming solution 20 is, for example, physiological saline.

[0032] The arterial supply / exhaust pipe 117 is connected between the arterial pressure measuring device 113 and the arterial protective filter 117f. A sixth valve 117v that opens and closes the arterial supply / exhaust pipe 117 is provided in the arterial supply / exhaust pipe 117. The arterial supply / exhaust pipe 117 is configured to be able to exhaust air from the arterial air trap chamber 112 and to supply air into the arterial air trap chamber 112.

[0033] The venous supply / exhaust pipe 118 is connected between the venous pressure measuring device 115 and the venous protective filter 118f. A seventh valve 118v that opens and closes the venous supply / exhaust pipe 118 is provided in the venous supply / exhaust pipe 118. The venous supply / exhaust pipe 118 is configured to be able to exhaust air from the venous air trap chamber 114 and to supply air into the venous air trap chamber 114.

[0034] Each of the arterial protection filter 117f and the venous protection filter 118f has the function of preventing blood from leaking out of the blood circuit and the function of preventing infection from the pressure measuring device.

[0035] Fig. 2 is a block diagram showing the electrical connections between the control unit and each component in the blood purification apparatus according to Embodiment 1 of the present invention. As shown in Fig. 2, the control unit 1 included in the blood purification apparatus 100 is electrically connected to each of the blood pump 111, the arterial on-off valve 110v, the venous on-off valve 116v, the first valve 141v, the second valve 131v, the third valve 151v, the fourth valve 152v, the fifth valve 191v, the sixth valve 117v, the seventh valve 118v, the arterial pressure measuring device 113, the venous pressure measuring device 115, the dialysate pump 160, the replacement fluid pump 161, the drainage pump 162, and the scale 180.

[0036] The control unit 1 receives an arterial measurement value measured by the arterial pressure measuring device 113 or a venous measurement value measured by the venous pressure measuring device 115. In this embodiment, the control unit 1 receives a venous measurement value, which is the pressure inside the venous air trap chamber 114 measured by the venous pressure measuring device 115. The control unit 1 receives a measurement value of the total weight change of the first weighing bag 140 and the second weighing bag 150 measured by the scale 180.

[0037] The control unit 1 controls the operation of each of the blood pump 111, the arterial side opening / closing valve 110v, the venous side opening / closing valve 116v, the first valve 141v, the second valve 131v, the third valve 151v, the fourth valve 152v, the fifth valve 191v, the sixth valve 117v, the seventh valve 118v, the dialysis fluid pump 160, the replacement fluid pump 161, and the drainage pump 162.

[0038] The following describes the operation for confirming during priming that no air has entered the first measuring bag 140 in the blood purification apparatus 100 according to this embodiment. Fig. 3 is a flowchart showing the operation for confirming during priming that no air has entered the first measuring bag in the blood purification apparatus according to the first embodiment of the present invention.

[0039] As shown in Figure 3, the control unit 1 performs a first step (S1) of operating the replacement fluid pump 161 and closing the venous opening / closing valve 116v during priming, in which the priming solution 20 is supplied from the priming solution pipeline 191 to the arterial blood circuit 110, the blood purifier 120, and the venous blood circuit 116.

[0040] Specifically, during priming when the blood pump 111 is stopped, the dialysate pump 160 is stopped, the drainage pump 162 is stopped, the arterial on-off valve 110v is closed, the first valve 141v is open, the second valve 131v is closed, the third valve 151v is closed, the fourth valve 152v is open, the fifth valve 191v is open, the sixth valve 117v is closed, and the seventh valve 118v is closed, and the priming solution 20 is being supplied from the priming solution conduit 191 to the arterial blood circuit 110, the blood purifier 120, and the venous blood circuit 116, the controller 1 closes the venous on-off valve 116v and rotates the replacement fluid pump 161 in the forward direction. As a result, if air is present in the first measuring bag 140, the air is sent into the venous air trap chamber 114.

[0041] The control unit 1 performs a second step (S2) of determining whether the increase in the venous measurement value after the venous on-off valve 116v is closed in the first step (S1) exceeds a threshold value within a certain period of time. The threshold value is, for example, 600 Pa or more and 700 Pa or less.

[0042] If the increase in the venous measurement value exceeds the threshold in the second step (S2), the control unit 1 performs a fourth step (S4) of temporarily opening the venous on-off valve 116v. This reduces the pressure in the venous air trap chamber 114. The venous on-off valve 116v is kept open for, for example, one second. After the fourth step (S4), the control unit 1 performs the first step (S1) again.

[0043] If the increase in the venous measurement value is equal to or less than the threshold value in the second step (S2), the controller 1 performs a third step (S3) of stopping the replacement fluid pump 161. The certain time period for making the determination in the second step (S2) is, for example, three seconds. That is, if the increase in the venous measurement value three seconds after the venous on-off valve 116v is closed is equal to or less than the threshold value, the controller 1 determines that no air has entered the first measuring bag 140 and stops the replacement fluid pump 161. The certain time period for making the determination can be set appropriately within a range of one second to five seconds.

[0044] By carrying out the above steps, it is possible to confirm during priming that no air has entered the first weighing bag 140, while suppressing an increase in the number of parts of the blood purification apparatus 100 by not installing a pressure sensor in the first weighing bag 140.

[0045] In this embodiment, fluid replacement line 131 is connected to venous blood circuit 116, and controller 1 determines whether or not air is present in first measuring bag 140 based on the increase in the venous measurement value, which is the pressure inside venous air trap chamber 114. This makes it possible to quickly confirm that no air has entered first measuring bag 140.

[0046] (Embodiment 2) A blood purification apparatus according to a second embodiment of the present invention will be described below with reference to the drawings. The blood purification apparatus according to the second embodiment of the present invention differs from the blood purification apparatus 100 according to the first embodiment of the present invention mainly in that the replacement fluid line is connected to the arterial blood circuit, and therefore, description of the same components as those of the blood purification apparatus 100 according to the first embodiment of the present invention will not be repeated.

[0047] FIG. 4 is a circuit diagram showing the configuration of a blood purification apparatus according to a second embodiment of the present invention. As shown in FIG. 4, in a blood purification apparatus 200 according to the second embodiment of the present invention, a fluid replacement line 131 is connected to an arterial blood circuit 110. Specifically, the fluid replacement line 131 is connected to an arterial air trap chamber 112. The fluid replacement line 131 supplies the fluid replacement to the arterial blood circuit 110. The blood purification apparatus 200 employs a so-called pre-dilution method. An arterial measurement value, which is the pressure in the arterial air trap chamber 112 measured by an arterial pressure measuring device 113, is input to the control unit 1.

[0048] Hereinafter, an operation for confirming that no air has entered the first measuring bag 140 during priming in the blood purification apparatus 200 according to this embodiment will be described. Fig. 5 is a flowchart showing the operation for confirming that no air has entered the first measuring bag during priming in the blood purification apparatus according to the second embodiment of the present invention.

[0049] As shown in Figure 5, the control unit 1 performs a first step (S1) of operating the replacement fluid pump 161 and closing the venous opening / closing valve 116v during priming, in which the priming solution 20 is supplied from the priming solution pipeline 191 to the arterial blood circuit 110, the blood purifier 120, and the venous blood circuit 116.

[0050] Specifically, during priming when the blood pump 111 is stopped, the dialysate pump 160 is stopped, the drainage pump 162 is stopped, the arterial on-off valve 110v is closed, the first valve 141v is open, the second valve 131v is closed, the third valve 151v is closed, the fourth valve 152v is open, the fifth valve 191v is open, the sixth valve 117v is closed, and the seventh valve 118v is closed, and the priming solution 20 is being supplied from the priming solution conduit 191 to the arterial blood circuit 110, the blood purifier 120, and the venous blood circuit 116, the controller 1 closes the venous on-off valve 116v and rotates the replacement fluid pump 161 in the forward direction. As a result, if air is present in the first measuring bag 140, the air is sent into the arterial air trap chamber 112.

[0051] The control unit 1 performs a second step (S12) of determining whether the increase in the arterial measurement value after the venous on-off valve 116v is closed in the first step (S1) exceeds a threshold value within a certain period of time. The threshold value is, for example, 600 Pa or more and 700 Pa or less.

[0052] If the increase in the arterial measurement value exceeds the threshold in the second step (S12), the control unit 1 performs a fourth step (S4) of temporarily opening the venous on-off valve 116v. This reduces the pressure in the arterial air trap chamber 112. The venous on-off valve 116v is kept open for, for example, one second. After the fourth step (S4), the control unit 1 performs the first step (S1) again.

[0053] If the increase in the venous measurement value is equal to or less than the threshold value in the second step (S12), the controller 1 performs a third step (S3) of stopping the replacement fluid pump 161. The certain time period for making the determination in the second step (S12) is, for example, three seconds. That is, if the increase in the arterial measurement value three seconds after the venous on-off valve 116v is closed is equal to or less than the threshold value, the controller 1 determines that no air has entered the first measuring bag 140 and stops the replacement fluid pump 161. The certain time period for making the determination can be set appropriately within a range of one second to five seconds.

[0054] By carrying out the above steps, it is possible to confirm during priming that no air has entered the first weighing bag 140, while suppressing an increase in the number of parts of the blood purification device 200 by not installing a pressure sensor in the first weighing bag 140.

[0055] In this embodiment, the fluid replacement line 131 is connected to the arterial blood circuit 110, and the controller 1 determines whether or not air is present in the first measuring bag 140 based on the increase in the arterial measurement value, which is the pressure inside the arterial air trap chamber 112. This makes it possible to quickly confirm that no air has entered the first measuring bag 140.

[0056] The embodiments disclosed herein should be considered to be illustrative in all respects and not restrictive. The scope of the present invention is defined by the claims, not by the above description, and is intended to include all modifications within the meaning and scope of the claims. [Explanation of symbols]

[0057] 1 control unit, 10 first fluid, 20 priming fluid, 100, 200 blood purification device, 110 arterial blood circuit, 110v arterial on-off valve, 111 blood pump, 112 arterial air trap chamber, 113 arterial pressure measuring device, 114 venous air trap chamber, 115 venous pressure measuring device, 116 venous blood circuit, 116v venous on-off valve, 117 arterial supply and exhaust pipe, 117f arterial protection filter, 117v sixth valve, 118 venous supply and exhaust pipe, 118f venous protection filter, 118v seventh valve, 120 blood purifier, 121 blood inlet, 122 blood outlet, 123 drainage outlet, 124 dialysis fluid inlet, 130 first supply source, 131 replacement fluid pipe, 131v second valve, 132 First connecting line, 140 First measuring bag, 141 Dialysis fluid line, 141v First valve, 150 Second measuring bag, 151 Drainage line, 151v Third valve, 152 Second connecting line, 152v Fourth valve, 160 Dialysis fluid pump, 161 Replacement fluid pump, 162 Drainage pump, 170 First heater, 171 Second heater, 180 Scale, 181 Storage section, 190 Primer fluid supply source, 191 Primer fluid line, 191v Fifth valve.

Claims

1. Blood purifier and an arterial blood circuit connected to the blood purifier for allowing blood to flow into the blood purifier; a venous blood circuit connected to the blood purifier for allowing blood to flow out of the blood purifier; a fluid replacement line connected to the arterial blood circuit or the venous blood circuit for supplying a replacement fluid; a dialysate line for supplying dialysate to the blood purifier; a drainage pipe through which the drainage liquid discharged from the blood purifier flows; a blood pump provided in the arterial blood circuit for pumping blood; an arterial air trap chamber provided in the arterial blood circuit; an arterial on-off valve provided in the arterial blood circuit for opening and closing the arterial blood circuit; a venous air trap chamber provided in the venous blood circuit; a venous on-off valve provided in the venous blood circuit for opening and closing the venous blood circuit; a priming solution line connected to the arterial blood circuit between the arterial on-off valve and the blood pump, for supplying a priming solution; a replacement fluid pump provided in the replacement fluid line and configured to pump out the replacement fluid; a dialysate pump provided in the dialysate line for pumping the dialysate; a drainage pump provided in the drainage pipeline for pumping out the drainage liquid; a first measuring bag connected to the replacement fluid line, which temporarily stores the replacement fluid and can deliver the stored replacement fluid; a scale capable of measuring a change in weight of the first weighing bag; an arterial pressure measuring device for measuring the pressure in the arterial air trap chamber; a venous pressure measuring device for measuring the pressure in the venous air trap chamber; a control unit to which an arterial measurement value measured by the arterial pressure measuring device or a venous measurement value measured by the venous pressure measuring device is input, The control unit a first step of closing the venous on-off valve while operating the replacement fluid pump during priming in which the priming solution is supplied from the priming solution conduit to the arterial blood circuit, the blood purifier, and the venous blood circuit; performing a second step of determining whether an increase in the arterial side measurement value or the venous side measurement value after the venous side on-off valve is closed in the first step exceeds a threshold value within a certain period of time; When the increase in the arterial side measurement value or the venous side measurement value exceeds the threshold value in the second step, a fourth step of temporarily opening the venous side on-off valve is performed, and then the first step is performed again; When the increase in the arterial measurement value or the venous measurement value is equal to or less than the threshold value in the second step, a third step of stopping the fluid replacement pump is carried out.

2. the fluid replacement line is connected to the venous blood circuit, The venous side measurement value is input to the control unit, The control unit performing a second step of determining whether an increase in the venous measurement value after the venous on-off valve is closed in the first step exceeds the threshold value within a certain period of time; When the increase in the venous side measurement value exceeds the threshold value in the second step, the fourth step of temporarily opening the venous side on-off valve is performed, and then the first step is performed again; 2. The blood purification apparatus according to claim 1, wherein when the increase in the venous measurement value is equal to or less than the threshold value in the second step, the third step of stopping the fluid replacement pump is performed.

3. the fluid replacement line is connected to the arterial blood circuit, The arterial measurement value is input to the control unit, The control unit performing a second step of determining whether an increase in the arterial measurement value after the venous valve is closed in the first step exceeds the threshold value within a certain period of time; When the increase in the arterial measurement value exceeds the threshold value in the second step, the fourth step of temporarily opening the venous on-off valve is performed, and then the first step is performed again; 2. The blood purification apparatus according to claim 1, wherein when the increase in the arterial measurement value is equal to or less than the threshold value in the second step, the third step of stopping the fluid replacement pump is carried out.

4. a second measuring bag connected to the drainage line, for temporarily storing the drainage liquid, and for discharging the stored drainage liquid; 4. The blood purification apparatus according to claim 1, wherein the scale measures a change in the total weight of the first weighing bag and the second weighing bag.

5. The blood purification apparatus according to claim 1 , wherein the threshold value is equal to or greater than 600 Pa and equal to or less than 700 Pa.

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