Oil-based emulsions in water

Abstract

To provide an oil-in-water emulsion composition that contains nicotinamide and has a superior effect of giving skin firmness, offering a good feeling of use with less stickiness, and demonstrates excellent emulsion stability.SOLUTION: An oil-in-water emulsion composition contains following components: (A) nicotinamide 1-10 mass%, (B) hydrogenated phospholipids 0.001-1.5 mass%, (C) a nonionic surfactant 0.1-3.5 mass%, (D) water-soluble polymers 0.02-0.5 mass%, (E) an oil-based component that is pasty at 25°C, (F) a polyhydric alcohol 5-25 mass%, and (G) water.SELECTED DRAWING: None

Description

[Technical Field]

[0001] The present invention relates to an oil-in-water emulsion composition, and in particular to an oil-in-water emulsion composition containing nicotinamide. [Background technology]

[0002] Factors that greatly affect the aesthetic appearance of skin include wrinkles, sagging, age spots, and pigmentation. Many drugs have been proposed to prevent or improve wrinkles and sagging, and among them, nicotinamide, a vitamin, is known to be highly safe and to have anti-aging effects on the skin (Patent Documents 1 and 2). However, it is known that products containing large amounts of nicotinamide can have undesirable textures, such as stickiness (Patent Document 3).

[0003] In particular, unlike pharmaceuticals, cosmetic properties and stability are important factors, and although various studies have been conducted, no emulsion containing nicotinamide, which is stable and also satisfies the sensory requirements, has been obtained. [Prior art documents] [Patent documents]

[0004] [Patent Document 1] Japanese Patent Application Publication No. 10-130135 [Patent Document 2] Japanese Patent Application Publication No. 10-001414 [Patent Document 3] Special Publication No. 2003-502435 Summary of the Invention [Problem to be solved by the invention]

[0005] The present invention has been made in view of the above circumstances, and aims to provide an oil-in-water emulsion composition which contains nicotinamide, has an excellent effect of imparting firmness and elasticity to the skin, has an excellent feel in use with little stickiness, and has excellent emulsion stability. [Means for solving the problem]

[0006] The oil-in-water emulsion composition of the present invention is characterized by containing the following components: (A) Nicotinamide 1 to 10% by mass (B) Hydrogenated phospholipid 0.001 to 1.5% by mass (C) Nonionic surfactant 0.1 to 3.5 mass% (D) Water-soluble polymer 0.02~0.5% by mass (E) an oily component that is paste-like at 25°C (F) Polyhydric alcohol 5 to 25% by mass (G)Water

[0007] The component (D) is characterized in that it contains hyaluronic acid or a salt thereof and Tremella fuciformis polysaccharide.

[0008] The content of the component (F) is 5 to 20% by mass.

[0009] The component (E) contains a dipentaerythritol fatty acid ester, and the content of the dipentaerythritol fatty acid ester is 0.5 to 2.0% by mass.

[0010] The component (C) is characterized in that it contains a polyglycerin fatty acid ester and a sucrose fatty acid ester.

[0011] The polyglycerol fatty acid ester has an HLB value of 10 to 15, and the content of the polyglycerol fatty acid ester is 1.2 to 2.0% by mass.

[0012] The sucrose fatty acid ester has an HLB value of 5 to 9, and the content of the sucrose fatty acid ester is 0.5 to 1.5% by mass.

[0013] Furthermore, the composition is characterized by containing, as component (H), one or more selected from higher alcohols and alkyl glyceryl ethers. [Effects of the Invention]

[0014] The oil-in-water emulsion composition of the present invention contains the above components (A) to (G), and therefore has an excellent effect of imparting firmness and elasticity to the skin, an excellent feeling of use with little stickiness, and excellent emulsion stability. DETAILED DESCRIPTION OF THE INVENTION

[0015] The present invention will be described in detail below. In this specification, the symbol "to" means a range including the numerical values ​​before and after it.

[0016] <1> Ingredient (A): Nicotinamide Component (A) in the present invention is an amide compound of nicotinic acid (vitamin B3 / niacin), a water-soluble vitamin. Nicotinamide may be derived from an extract of a natural product (such as rice bran) or may be synthesized by a known method. Specifically, those listed in the Japanese Pharmacopoeia can be used. Nicotinamide is known to have effects such as improving rough skin, inhibiting melanin production, and whitening effects.

[0017] In the present invention, the content of component (A) is 1 to 10% by mass based on the total amount of the oil-in-water emulsion composition. This improves skin firmness and elasticity while suppressing stickiness. In the present invention, since excellent emulsion stability is exhibited even when nicotinamide is contained at a high concentration, the content of component (A) is preferably 3 to 10% by mass, more preferably 4 to 7% by mass.

[0018] <2> Component (B): Hydrogenated phospholipid Component (B) in the present invention is a phospholipid whose unsaturated carbon chain has been saturated by hydrogenation. Examples of hydrogenated phospholipids include hydrogenated products of phosphatidylcholine (PC), phosphatidylethanolamine, phosphatidylserine, phosphatidic acid, phosphatidylinositol, etc., and hydrogenated lecithins such as soybean lecithin and egg yolk lecithin extracted from natural soybeans or egg yolks. Component (B) in the present invention also includes hydrogenated products of lysophospholipids, in which one fatty acid group has been removed from a phospholipid. One or more of the above hydrogenated products can be used as component (B).

[0019] From the viewpoint of emulsion stability, it is preferable that component (B) contains hydrogenated lecithin. The PC content of hydrogenated lecithin is, for example, 10 to 70% by mass. Commercially available products that can be used include, for example, Resinol S-10 (hydrogenated soybean phospholipid: PC content 25 to 30% by mass) and Resinol S-10M (hydrogenated soybean phospholipid: PC content 55 to 65% by mass) from Nikko Chemicals Co., Ltd.

[0020] In the present invention, the content of component (B) is 0.001 to 1.5% by mass based on the total amount of the oil-in-water emulsion composition. Furthermore, from the viewpoint of improving stickiness and emulsion stability, the content of component (B) is preferably 0.05 to 1.0% by mass, and more preferably 0.1 to 0.5% by mass.

[0021] <3> Component (C): Nonionic surfactant Component (C) in the present invention is a surfactant that does not become ionic when dissolved in water, and includes ether, ester, and ether ester types. Examples of nonionic surfactants include glycerin fatty acid esters, polyglycerin fatty acid esters, sucrose fatty acid esters, propylene glycol fatty acid esters, sorbitan fatty acid esters, polyoxyethylene sorbitan fatty acid esters, polyoxyethylene sorbitan fatty acid esters, polyoxyethylene sorbitan fatty acid esters, polyoxyethylene alkyl ethers, polyoxyethylene polyoxypropylene glycol, polyoxyethylene polyoxypropylene alkyl ethers, polyethylene glycol fatty acid esters, polyoxyethylene castor oil, polyoxyethylene hydrogenated castor oil, and alkyl glycosides. One or more of these surfactants can be used as component (C).

[0022] The fatty acids constituting the nonionic surfactants containing the fatty acid esters exemplified above can be lauric acid, myristic acid, palmitic acid, stearic acid, linoleic acid, linolenic acid, behenic acid, etc. The number of fatty acids bonded is preferably 1 to 3.

[0023] In the present invention, the content of component (C) is 0.1 to 3.5% by mass based on the total amount of the oil-in-water emulsion composition. Furthermore, from the viewpoints of improving stickiness and emulsion stability, the content of component (C) is preferably 1.0 to 3.5% by mass, more preferably 2.0 to 3.5% by mass.

[0024] From the viewpoint of emulsion stability, component (C) preferably contains a polyglycerol fatty acid ester and a sucrose fatty acid ester. In this case, the HLB value of the polyglycerol fatty acid ester is preferably higher than that of the sucrose fatty acid ester. Specifically, the HLB value of the polyglycerol fatty acid ester is preferably 10 to 15, and the HLB value of the sucrose fatty acid ester is preferably 5 to 9. The number of fatty acids and the number of carbon atoms of the fatty acids in these fatty acid esters are adjusted so that the HLB values ​​fall within the respective ranges. For example, an example of a polyglycerol fatty acid ester with an HLB value of 10 to 15 is polyglyceryl monostearate (HLB value 12). An example of a sucrose fatty acid ester with an HLB value of 5 to 9 is sucrose distearate (HLB value 7).

[0025] In the composition containing the above two fatty acid esters, the content of the polyglycerol fatty acid ester is preferably 0.5 to 2.0% by mass, more preferably 1.2 to 2.0% by mass, based on the total amount of the oil-in-water emulsion composition. The content of the sucrose fatty acid ester is preferably 0.5 to 2.0% by mass, more preferably 0.5 to 1.5% by mass, based on the total amount of the oil-in-water emulsion composition. Furthermore, the ratio of the content of the polyglycerol fatty acid ester to the content of the sucrose fatty acid ester is preferably (1:1) to (2:1), more preferably (1.2:1) to (1.5:1).

[0026] By combining two nonionic surfactants with different HLB values, an oil-in-water emulsion composition with even better emulsion stability can be obtained. In addition to the two nonionic surfactants described above, other nonionic surfactants may also be added.

[0027] In the present invention, the HLB value is expressed as IOB x 10 in the organic conceptual diagram. The IOB in the organic conceptual diagram refers to the ratio of the inorganic value (IV) to the organic value (OV) in the organic conceptual diagram, i.e., "inorganic value (IV) / organic value (OV)." The organic conceptual diagram was proposed by Atsushi Fujita, and its details are explained in "Pharmaceutical Bulletin," 1954, Vol. 2, pp. 163-173; "The Domain of Chemistry," 1957, Vol. 11, pp. 719-725; and "Fragrance Journal," 1981, Vol. 50, pp. 79-82. Specifically, all organic compounds are considered to be derived from methane (CH4), and all other compounds are considered to be derivatives of methane. The carbon number, substituents, modification sites, rings, and other parameters are assigned specific values, and the organic and inorganic values ​​are calculated by adding these scores. These values ​​are plotted on a diagram with the organic value on the X axis and the inorganic value on the Y axis. This organic concept diagram is also shown in "Organic Concept Diagram - Basics and Applications" (by Yoshio Koda, Sankyo Publishing, 1984).

[0028] <4> Component (D): Water-soluble polymer Component (D) in the present invention is a general term for polymers that provide a thickening effect when made into an aqueous solution and the pH is adjusted as necessary. For example, sodium polyacrylate, cellulose ether, calcium alginate, carboxyvinyl polymer, ethylene / acrylic acid copolymer, vinylpyrrolidone polymer, vinyl alcohol / vinylpyrrolidone copolymer, nitrogen-substituted acrylamide polymer, polyacrylamide, cationic polymers such as cationized guar gum, dimethylacrylammonium polymer, acrylic acid / methacrylic acid copolymer, polyoxyethylene (POE) / polyoxypropylene (POP) copolymer, polyvinyl alcohol, hyaluronic acid or a salt thereof, chondroitin sulfate or a salt thereof, Tremella fuciformis polysaccharide, collagen, pullulan, agar, gelatin, tamarind seed polysaccharide, xanthan gum, carrageenan, high methoxyl pectin, low methoxyl pectin, guar gum, gum arabic, crystalline cellulose, arabinogalactan, karaya gum, tragacanth gum, alginate, albumin, casein, curdlan, gellan gum, dextran, cellulose, polyethyleneimine, polyethylene glycol, high polymerization degree polyethylene glycol, cationized silicone polymer, and the like. One or more of these can be used as component (D).

[0029] In the present invention, the content of component (D) is 0.02 to 0.5% by mass, preferably 0.02 to 0.3% by mass, and more preferably 0.02 to 0.1% by mass, based on the total amount of the oil-in-water emulsion composition.

[0030] In particular, from the viewpoint of emulsion stability, component (D) preferably contains hyaluronic acid or a salt thereof and Tremella fuciformis polysaccharide. Hyaluronic acid is a polysaccharide generally known as a moisture-retaining component. Examples of hyaluronic acid salts include sodium salt, potassium salt, calcium salt, and ammonium salt. Tremella fuciformis polysaccharide is a water-soluble polysaccharide obtained from mushrooms belonging to the Tremella family. The content of hyaluronic acid or a salt thereof is preferably 0.001 to 0.1% by mass, more preferably 0.005 to 0.01% by mass, based on the total amount of the oil-in-water emulsion composition. The content of Tremella fuciformis polysaccharide is preferably 0.00005 to 0.001% by mass, more preferably 0.0001 to 0.001% by mass.

[0031] Furthermore, component (D) may contain, in addition to hyaluronic acid or a salt thereof and Tremella fuciformis polysaccharide, other water-soluble polymers. The other water-soluble polymers are preferably one or more selected from the group consisting of carboxyvinyl polymers, chondroitin sulfate or a salt thereof, xanthan gum, and polyethylene glycol. The carboxyvinyl polymer is an acidic polymer primarily composed of an acrylic acid polymer, and commercially available products can be used. Xanthan gum is a polysaccharide obtained by fermentation with Xanthomonas campestris. Component (D) preferably contains at least a carboxyvinyl polymer as the other water-soluble polymer, and the content thereof is, for example, 0.01 to 0.1% by mass.

[0032] <5> Ingredient (E): An oily ingredient that is paste-like at 25°C Component (E) in the present invention is a semi-solid component that exhibits high viscosity at 25°C and is an oil agent with a melting point higher than 25°C. The "melting point" here is measured based on the method described in the "General Testing Method for Quasi-drugs" section of the "Melting Point Measurement Method." Examples of component (E) in the present invention include petrolatum, lanolin, shea butter, hydrogenated palm oil, dimer dilinoleate (phytosteryl / isostearyl / cetyl / stearyl / behenyl), pentaerythritol tetra(behenate / benzoate / ethylhexanoate), and dipentaerythritol fatty acid ester. One or more of these can be used as component (E).

[0033] In the present invention, the content of component (E) is preferably 0.5 to 5 mass %, more preferably 1 to 3 mass %, based on the total amount of the oil-in-water emulsion composition.

[0034] In particular, from the viewpoint of emulsion stability, it is preferable that component (E) contains a dipentaerythritol fatty acid ester. Examples of dipentaerythritol fatty acid esters include dipentaerythritol hexaoxystearate and dipentaerythritol rosinate. The dipentaerythritol fatty acid ester is more preferably contained in an amount of 0.5 to 2.0 mass% based on the total amount of the oil-in-water emulsion composition. Furthermore, the ratio of the content of the dipentaerythritol fatty acid ester to the content of the above-mentioned component (C) is preferably (1:1.5) to (1:3), more preferably (1:2) to (1:3).

[0035] <6> Ingredient (F): Polyhydric alcohol Component (F) in the present invention can be any compound commonly used in the fields of cosmetics, pharmaceuticals, etc., and is not particularly limited. Examples include 1,3-propanediol, 1,2-pentanediol, diethylene glycol, propylene glycol, 1,3-butylene glycol, ethylene glycol, triethylene glycol, ethylene glycol monoethyl ether, ethylene glycol monobutyl ether, diethylene glycol monomethyl ether, diethylene glycol monoethyl ether, polyethylene glycol, polypropylene glycol, pentyl glycol, glycerin, diglycerin, pentaerythritol, threitol, arabitol, xylitol, galactitol, sorbitol, lactitol, and maltitol. One or more of these compounds can be used as component (F).

[0036] Among the above polyhydric alcohols, it is preferable to use one or more selected from 1,3-butylene glycol, 1,3-propanediol, and glycerin, and it is more preferable to use a combination of 1,3-butylene glycol and glycerin. In the latter case, component (F) preferably contains 1,3-butylene glycol in an amount of 60% by mass or more, more preferably 65% ​​by mass or more, based on the total amount of polyhydric alcohols.

[0037] In the present invention, the content of component (F) is 5 to 25% by mass, preferably 5 to 20% by mass, and more preferably 10 to 20% by mass, based on the total amount of the oil-in-water emulsion composition.

[0038] <7> Ingredient (G): Water Component (G) in the present invention can be any material commonly used in the fields of cosmetics, pharmaceuticals, etc., without any particular limitations. In addition to water, purified water, hot spring water, deep sea water, etc. can also be used, and one or more of these can be used as appropriate. The content of component (G) is not particularly limited, but is preferably 30 to 70 mass%.

[0039] The oil-in-water emulsion composition of the present invention may contain other components in addition to components (A) to (G). For example, it is preferable to contain the following component (H) as an oil component of the oil-in-water emulsion composition.

[0040] <8> Component (H): One or more selected from higher alcohols and alkyl glyceryl ethers The higher alcohol of component (H) in the present invention is a general term for monohydric alcohols having six or more carbon atoms. Examples of higher alcohols that can be used include decomposition alcohols obtained by hydrolysis (saponification) of waxes, reduced alcohols obtained by high-pressure hydrogen reduction of fatty acids, and synthetic alcohols obtained from petroleum resources.

[0041] The higher alcohol is preferably a monohydric alcohol having 6 or more carbon atoms and having a linear saturated alkyl group with 14 to 22 carbon atoms. Such higher alcohols are solid at 25°C, and examples thereof include myristyl alcohol, cetyl alcohol, stearyl alcohol, and behenyl alcohol.

[0042] Furthermore, the alkyl glyceryl ether of component (H) in the present invention is a general term for compounds having an alkyl group, in which an ether bond is formed between the hydroxyl group of glycerol and an alcohol.

[0043] The alkyl glyceryl ether may be any one of monoalkyl glyceryl ether, dialkyl glyceryl ether, and trialkyl glyceryl ether, or a mixture thereof. Among these, monoalkyl glyceryl ether is preferred, and those having a linear or branched alkyl group with 14 to 22 carbon atoms are more preferred. The alkyl glyceryl ether is solid at 25°C, and examples thereof include batyl alcohol and chimyl alcohol.

[0044] In the present invention, the content of component (H) is preferably 2 to 10 mass %, more preferably 4 to 8 mass %, based on the total amount of the oil-in-water emulsion composition. Furthermore, component (H) preferably contains a higher alcohol and an alkyl glyceryl ether.

[0045] The oil-in-water emulsion composition of the present invention preferably contains an oily component other than the above-mentioned component (H). For example, it is preferable to blend an oily component that has a melting point lower than 25°C and is liquid at 25°C. Examples of oily components that are liquid at 25°C include hydrocarbon oils such as liquid paraffin, α-olefin oligomer, and squalane; ester oils such as isopropyl myristate, myristyl myristate, octyldodecyl myristate, isopropyl palmitate, and isopropyl adipate; vegetable oils such as soybean oil, rice bran oil, jojoba oil, avocado oil, almond oil, olive oil, cacao oil, sesame oil, persic oil, castor oil, coconut oil, and macadamia nut oil; silicone oils such as methylpolysiloxane, methylphenylpolysiloxane, and methylcyclopolysiloxane; and higher fatty acids such as oleic acid.

[0046] The oil-in-water emulsion composition of the present invention more preferably contains, as oil components, component (E), component (H), and an oil component that is liquid at 25°C. In this configuration, the total amount of oil components is preferably 10 to 35% by mass, and more preferably 20 to 35% by mass, based on the total amount of the oil-in-water emulsion composition. Furthermore, the amount of oil components that are liquid at 25°C is, for example, 40 to 70% by mass, based on the total amount of oil components. Note that with regard to surfactants, the portion that dissolves in the oil component is treated as the oil component, and the portion that dissolves in the aqueous component is treated as the aqueous component.

[0047] Furthermore, the oil-in-water emulsion composition of the present invention may also contain, as needed, water-soluble vitamins, amino acid derivatives, inorganic salts, chelating agents, preservatives, pH adjusters, pigments, water-soluble drugs, etc. Preferably, the oil-in-water emulsion composition of the present invention does not contain an anionic surfactant or a cationic surfactant as a surfactant.

[0048] The method for producing the oil-in-water emulsion composition of the present invention is not particularly limited, and in addition to conventional emulsification, methods such as multi-stage emulsification, D-phase emulsification, phase inversion emulsification, liquid crystal emulsification, PIT emulsification, gel emulsification, and membrane emulsification can be selected. The emulsification apparatus is also not particularly limited, and in addition to conventional emulsification apparatus such as a stirrer, impeller agitator, and homomixer, high-pressure emulsifiers such as a Manton-Gaulin type high-pressure homogenizer, a water jet reversal type high-pressure emulsifier, a microfluidizer, a nanomizer, and a starburst can also be used, and the required particle size can be obtained by combining one or more of these.

[0049] The oil-in-water emulsion composition of the present invention can be formulated into various dosage forms by combining it with other ingredients, such as gel, paste, liquid, cream, and solid forms. [Example]

[0050] The present invention will be specifically explained below by way of examples, but the present invention is not limited to these examples in any way.

[0051] The compositions and results of the examples and comparative examples are shown in Table 1. The manufacturing method was as follows: Phase A and Phase B were each heated to 80°C, and Phase B was gradually added to Phase A while stirring with a homomixer, followed by cooling. Phase C was then added.

[0052] [Table 1]

[0053] Note 1) Nikkol Decaglin 1-SV (HLB value: 12) manufactured by Nippon Surfactant Industries Co., Ltd. Note 2) Nikko Chemicals Resinol S-10 Note 3) Nikko Chemicals Resinol S-10M Note 4) Nisshin Oillio Group Co., Ltd. Cosmol 168M Note 5) Mitsubishi Chemical Foods Surfhope SE COSME C-1807 (HLB value: 7) Note 6) Nikkor MGS-F75V (HLB value: 1.5) manufactured by Nippon Surfactant Industries Co., Ltd.

[0054] The "emulsion stability" in Table 1 was determined as follows: The formulation was filled into a transparent glass bottle and stored at 40°C and 75% RH for 6 months. The emulsified state was visually confirmed. ○: No changes in state such as separation or aggregation are observed. △: Slight changes in state such as separation and aggregation are observed. ×: A change in state such as separation or aggregation is clearly observed. In addition, in Comparative Example 5 (marked with *), the desired emulsified state was not obtained immediately after preparation.

[0055] All of Examples 1 to 7 provided oil-in-water emulsion compositions that were excellent in the effect of imparting firmness and elasticity to the skin, had an excellent feel in use with little stickiness, and had excellent emulsion stability.

Claims

1. An oil-in-water emulsion composition comprising the following components, wherein component (D) comprises hyaluronic acid or a salt thereof and Tremella fuciformis polysaccharide: (A) Nicotinamide 1 to 10% by mass (B) Hydrogenated phospholipid 0.001 to 1.5% by mass (C) Nonionic surfactant: 0.1 to 3.5% by mass (D) Water-soluble polymer 0.02 to 0.1% by mass (E) an oily component that is paste-like at 25°C (F) Polyhydric alcohol 5 to 25% by mass (G) Water

2. 2. The oil-in-water emulsion composition according to claim 1, wherein the content of the component (F) is 5 to 20% by mass.

3. 3. The oil-in-water emulsion composition according to claim 1, wherein the component (E) contains a dipentaerythritol fatty acid ester, and the content of the dipentaerythritol fatty acid ester is 0.5 to 2.0% by mass.

4. 4. The oil-in-water emulsion composition according to claim 1, wherein the component (C) contains a polyglycerin fatty acid ester and a sucrose fatty acid ester.

5. 5. The oil-in-water emulsion composition according to claim 4, wherein the polyglycerol fatty acid ester has an HLB value of 10 to 15, and the content of the polyglycerol fatty acid ester is 1.2 to 2.0% by mass.

6. 6. The oil-in-water emulsion composition according to claim 4, wherein the sucrose fatty acid ester has an HLB value of 5 to 9, and the content of the sucrose fatty acid ester is 0.5 to 1.5% by mass.

7. 7. The oil-in-water emulsion composition according to claim 1, further comprising at least one selected from higher alcohols and alkyl glyceryl ethers as component (H).

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