Liquid storage container, liquid-filled container, method for producing a predetermined amount of medicinal liquid, combination, method for producing combination, and method for producing liquid-filled container

Abstract

To provide a liquid storage container configured so that when liquid stored in the liquid storage container is extracted, the liquid can be suppressed from remaining in the liquid storage container, a liquid-filled container, a method for manufacturing a specified quantity of medical solutions, a combined body, a method for manufacturing a combined body, and a method for manufacturing a liquid-filled container.SOLUTION: A liquid storage container 10 comprises a container main body 11 that can store liquid, and a sealed part 20 formed at a first side end of the container main body. The container main body has a cylindrical trunk part 12 and a linking part 13 formed continuously between the trunk part and the sealed part. A sealing line 21 is formed between the linking part and the sealed part, where first corner parts 22 and 23 are formed respectively, by the sealing line and the linking part, at positions of both ends of the sealing line. When viewed from a normal direction of a virtual surface which is parallel to a main surface of the sealed part and includes the sealing line, the first corner part has both of a first corner portion having an angle of 50° or less and a first corner portion having an angle of 100° or more.SELECTED DRAWING: Figure 1

Description

[Technical Field]

[0001] The present disclosure relates to a liquid storage container, a liquid-filled container, a method for producing a predetermined amount of a medicinal liquid, a combination, a method for producing a combination, and a method for producing a liquid-filled container. [Background technology]

[0002] Containers for transporting or storing liquid medicines are required to stably maintain a sealed state. Known examples of such containers include glass and resin vials.

[0003] For example, Patent Document 1 discloses a paper container for liquids having a cylindrical main body, a donut-shaped top, a synthetic resin stopper with a flange for heat-sealing to the top, and a cap that fits onto the stopper. Patent Document 1 offers the advantage of providing a tube-type paper container for liquids with a high paper content that can be supplied at low cost without using an in-mold injection molding method that uses expensive molds. Patent Document 2 also discloses a multilayer tube that includes a head with a content spout and a body connected to the head and formed into a fishtail shape at its tail end, the body having a laminated structure. Patent Document 2 offers the advantage of proposing a novel multilayer tube that reliably prevents oxygen from entering from the outside, reduces the effects of oxygen present in the interior space of the container, and maintains stable quality over a long period of time. [Prior art documents] [Patent documents]

[0004] [Patent Document 1] Japanese Patent Application Laid-Open No. 2012-025471 [Patent Document 2] Japanese Patent Application Laid-Open No. 2004-148628 Summary of the Invention [Problem to be solved by the invention]

[0005] When a liquid such as a medicinal solution is extracted from a liquid container such as a medical container, there is a problem that some liquid remains in the liquid container. If such a problem occurs, for example, it becomes impossible to extract all of the medicinal solution stored in the liquid container in a fixed amount and administer it to a patient. Furthermore, if the liquid stored in the liquid container is expensive, it becomes difficult to use the liquid without waste.

[0006] The present disclosure provides a liquid storage container, a liquid-filled container, a method for manufacturing a predetermined amount of medicinal liquid, a combination, a method for manufacturing a combination, and a method for manufacturing a liquid-filled container, which are capable of suppressing liquid residue in the liquid storage container when the liquid contained in the liquid storage container is removed. [Means for solving the problem]

[0007] The liquid storage container according to this embodiment is a liquid storage container comprising a container body capable of storing liquid and a sealing portion formed at a first side end of the container body, wherein the container body has a cylindrical body portion and a connecting portion formed continuously between the body portion and the sealing portion, a seal line is formed between the connecting portion and the sealing portion, and first corner portions are formed at both ends of the seal line by the seal line and the connecting portion, and when viewed from the normal direction of an imaginary plane parallel to the main surface of the sealing portion and including the seal line, all of the first corner portions form an angle of 50° or less, or the container has both first corner portions with an angle of 50° or less and first corner portions with an angle of 100° or more.

[0008] In the liquid storage container according to this embodiment, the contact angle of the inner surface of the container body with respect to the liquid may be 20° or more.

[0009] In the liquid storage container according to this embodiment, for a first corner portion that has an angle of 50° or less when viewed from the normal direction of the imaginary plane, when the first corner portion is observed from a direction parallel to the imaginary plane and perpendicular to the sealing line, the angle formed by the container body may be 35° or less.

[0010] In the liquid storage container according to this embodiment, a removal portion for removing the liquid stored inside the container body may be provided at a second side end of the container body.

[0011] The liquid storage container according to this embodiment may further include a liquid packaging bag arranged so as to communicate with the removal portion.

[0012] In the liquid storage container according to this embodiment, a second corner portion may be formed midway along the sealing line, and when viewed from the normal direction of the imaginary plane, the second corner portion may have an angle of 50° or less or 100° or more.

[0013] In the liquid storage container according to this embodiment, for a second corner portion that has an angle of 100° or more when viewed from the normal direction of the imaginary plane, when the second corner portion is cut by a plane perpendicular to the sealing line, the angle formed by the container body may be 40° or more.

[0014] The liquid container according to this embodiment includes the liquid storage container according to this embodiment and liquid stored in the liquid storage container.

[0015] A method for producing a predetermined amount of medicinal liquid according to this embodiment includes the steps of preparing a liquid-filled container according to this embodiment, forming an opening in the container body that communicates with the interior, and removing the liquid in the container body through the opening.

[0016] In the method for producing a predetermined amount of medicinal liquid according to this embodiment, the opening may be formed by a syringe needle, and the liquid in the container body may be extracted from the opening by the syringe needle.

[0017] The combination according to this embodiment is a combination comprising: a liquid storage container including a cylindrical container body having an opening and a closing portion and a central axis; and an engaging portion provided on the container body; and a mounting base on which the liquid storage container is placed and which has an engaged portion that engages with the engaging portion of the liquid storage container, wherein at least a portion of the peripheral portion of the opening is positioned on an opening surface, and the opening surface is inclined with respect to the central axis of the container body, and the liquid storage container is placed on the mounting base with the central axis of the container body inclined with respect to the bottom surface of the mounting base, and when the liquid storage container is placed on the mounting base, the opening surface opens in a direction opposite to the direction in which the liquid storage container is inclined with respect to the bottom surface of the mounting base.

[0018] In the combined product according to this embodiment, the engaging portion may include a convex portion or a concave portion.

[0019] In the combined product according to this embodiment, the opening surface and the bottom surface of the mounting table may be positioned parallel to each other.

[0020] In the combination according to this embodiment, the angle formed between the opening surface and a surface parallel to the bottom surface of the stage may be not less than −29° and not more than 13°.

[0021] In the combination according to this embodiment, the length of a first straight line connecting a first end point of the opening which is the farthest point from the closing portion and a second end point of the opening which is the closest point from the closing portion may be longer than the length of a second straight line which passes through the central axis and is perpendicular to the first straight line.

[0022] In the combination according to this embodiment, a mark indicating the liquid filling position may be provided on the liquid storage container or the placement table.

[0023] In the combination according to this embodiment, a plurality of the liquid storage containers may be placed on the table.

[0024] In the combination according to this embodiment, the mounting table has a mounting table main body and a protective cover that can be attached and detached to the mounting table main body, and the protective cover may be provided with a pressing portion that presses the liquid storage container.

[0025] The method for manufacturing a combination according to this embodiment is a method for manufacturing a combination, and includes the steps of preparing a liquid storage container including a cylindrical container body having an opening and a closing portion and a central axis, and an engaging portion provided on the container body; preparing a mounting base having an engaged portion that engages with the engaging portion of the liquid storage container; and placing the liquid storage container on the mounting base, wherein at least a portion of the peripheral portion of the opening is positioned on an opening surface, the opening surface being inclined with respect to the central axis of the container body, the liquid storage container being placed on the mounting base with the central axis of the container body inclined with respect to the bottom surface of the mounting base, and when the liquid storage container is placed on the mounting base, the opening surface is open in a direction opposite to the direction in which the liquid storage container is inclined with respect to the bottom surface of the mounting base.

[0026] The method for manufacturing a liquid-filled container according to this embodiment includes the steps of preparing an assembly according to this embodiment, filling the liquid storage container with a predetermined amount of liquid, and sealing the periphery of the opening of the liquid storage container. [Effects of the Invention]

[0027] According to this embodiment, when liquid contained in the liquid container is taken out, it is possible to prevent liquid from remaining in the liquid container. [Brief explanation of the drawings]

[0028] [Figure 1] 1 is a perspective view showing a liquid storage container according to a first embodiment. [Figure 2] FIG. 1 is a front view showing a liquid storage container according to a first embodiment. [Figure 3] 3 is a cross-sectional view (cross-sectional view taken along line III-III in FIG. 1) showing a liquid storage container according to the first embodiment. [Figure 4] 3 is an enlarged front view showing a first corner portion of the liquid storage container according to the first embodiment. FIG. [Figure 5] 2 is an enlarged bottom view (view taken in the direction of the arrow V in FIG. 1) showing a first corner portion of the liquid storage container according to the first embodiment. FIG. [Figure 6] 1 is a front view showing a liquid container according to a first embodiment. FIG. [Figure 7] FIG. 10 is a perspective view showing a liquid storage container according to a first modified example of the first embodiment. [Figure 8] FIG. 2 is a front view showing a liquid storage container according to a first modified example of the first embodiment. [Figure 9] FIG. 10 is a diagram showing a state in which a liquid container according to a first modified example of the first embodiment is being filled with liquid. [Figure 10] 10 is a front view showing a liquid storage container according to a first modified example of the first embodiment, in which the sealing line is arc-shaped. FIG. [Figure 11] 11 is a graph showing the range of preferable angles α1 and β1 in the liquid storage container shown in FIG. [Figure 12] 11 is a graph showing the ranges of preferred angles α2 and β2 in the liquid storage container shown in FIG. [Figure 13] FIG. 10 is a partially enlarged front view showing a liquid storage container according to a second modified example of the first embodiment. [Figure 14] 14 is a cross-sectional view showing a liquid storage container according to a second modified example of the first embodiment (cross-sectional view taken along line XIV-XIV in FIG. 13). FIG. [Figure 15] FIG. 10 is a partially enlarged front view showing a liquid storage container according to a third modified example of the first embodiment. [Figure 16] FIG. 10 is a front view showing a liquid storage container according to a fourth modified example of the first embodiment. [Figure 17] 10 is a diagram illustrating a method for measuring the angle of a first corner portion when the liquid container is viewed from the normal direction of an imaginary plane. FIG. [Figure 18]This is a diagram explaining how to measure the angle formed by the container body when the first corner portion is observed parallel to the imaginary plane and perpendicular to the seal line (for the first corner portion where the angle when the liquid container is viewed from the normal direction of the imaginary plane is less than 90°). [Figure 19] This is a diagram explaining how to measure the angle formed by the container body when the first corner portion is observed parallel to the imaginary plane and perpendicular to the seal line (when the first corner portion forms an angle of 90° or more when the liquid container is viewed from the normal direction of the imaginary plane). [Figure 20] FIG. 10 is an enlarged front view showing a first corner portion of a liquid storage container according to a comparative example. [Figure 21] FIG. 10 is a front view showing a sealed liquid storage container according to a second embodiment. [Figure 22] FIG. 10 is a perspective view showing a liquid storage container according to a second embodiment before being sealed. [Figure 23] FIG. 10 is a front view showing a liquid storage container before being sealed according to a second embodiment. [Figure 24] FIG. 10 is a front view showing a liquid storage container before being sealed according to a modification of the second embodiment. [Figure 25] FIG. 10 is a diagram showing a liquid storage container according to a modified example of the second embodiment. [Figure 26] FIG. 10 is a diagram showing a liquid storage container according to a modified example of the second embodiment. [Figure 27] FIG. 10 is a diagram showing a liquid storage container according to a modified example of the second embodiment. [Figure 28] FIG. 10 is a diagram showing a liquid storage container according to a modified example of the second embodiment. [Figure 29] 10A and 10B are diagrams illustrating the effects of the liquid storage container according to the second embodiment. [Figure 30] 10A and 10B are diagrams illustrating the effects of the liquid storage container according to the second embodiment. [Figure 31] 10A and 10B are diagrams illustrating the effects of the liquid storage container according to the second embodiment. [Figure 32] FIG. 10 is a perspective view showing an assembly according to a second embodiment. [Figure 33]FIG. 10 is a perspective view showing an assembly according to a second embodiment. [Figure 34] FIG. 10 is a front view showing an assembly according to a second embodiment. [Figure 35] 10A and 10B are diagrams comparing the liquid storage container in the second embodiment when it is tilted and when it is not tilted. [Figure 36] FIG. 10 is a cross-sectional view showing an assembly according to a modified example of the second embodiment. [Figure 37] FIG. 10 is a diagram showing an opening of a liquid storage container in a second embodiment. [Figure 38] 10A and 10B are diagrams illustrating a modified example of the liquid storage container according to the second embodiment. [Figure 39] FIG. 10 is a cross-sectional view showing an assembly according to a first modified example of the second embodiment. [Figure 40] FIG. 10 is a cross-sectional view showing an assembly according to a second modified example of the second embodiment. [Figure 41] FIG. 10 is a cross-sectional view showing an assembly according to a third modified example of the second embodiment. [Figure 42] FIG. 10 is a cross-sectional view showing an assembly according to a fourth modified example of the second embodiment. [Figure 43] FIG. 10 is a cross-sectional view showing an assembly according to a fifth modified example of the second embodiment. [Figure 44] FIG. 10 is a cross-sectional view showing an assembly according to a fifth modified example of the second embodiment. [Figure 45] FIG. 10 is a cross-sectional view showing an assembly according to a sixth modified example of the second embodiment. [Figure 46] FIG. 10 is a cross-sectional view showing an assembly according to a sixth modified example of the second embodiment. [Figure 47] FIG. 10 is a cross-sectional view showing an assembly according to a sixth modified example of the second embodiment. [Figure 48] FIG. 10 is a cross-sectional view showing an assembly according to a sixth modified example of the second embodiment. [Figure 49] FIG. 10 is a cross-sectional view showing an assembly according to a sixth modified example of the second embodiment. [Figure 50] FIG. 10 is a cross-sectional view showing an assembly according to a sixth modified example of the second embodiment. [Figure 51] FIG. 13 is a perspective view showing an assembly according to a seventh modified example of the second embodiment. [Figure 52] 51. FIG. 52 is a cross-sectional view (cross-sectional view taken along line LII-LII in FIG. 51) showing an assembly according to a seventh modified example of the second embodiment. [Figure 53] FIG. 13 is a cross-sectional view showing a state in which a liquid storage container is being filled with liquid in a seventh modified example of the second embodiment. [Figure 54] FIG. 13 is a plan view showing a liquid container housed in a mounting table main body in a seventh modified example of the second embodiment. [Figure 55] FIG. 13 is a perspective view showing a mounting table body according to a seventh modification of the second embodiment. [Figure 56] FIG. 13 is a perspective view showing a liquid container housed in a mounting table main body in a seventh modified example of the second embodiment. [Figure 57] FIG. 10 is a cross-sectional view showing a state in which a plurality of combined bodies according to a seventh modification of the second embodiment are stacked one on top of the other. [Figure 58] FIG. 13 is a perspective view showing a liquid storage container according to an eighth modified example of the second embodiment. [Figure 59] 59 is a partial cross-sectional view (cross-sectional view taken along line LIX-LIX in FIG. 58) showing a liquid storage container according to an eighth modified example of the second embodiment. [Figure 60] FIG. 13 is a cross-sectional view showing an assembly according to an eighth modified example of the second embodiment. [Figure 61] 61 is a cross-sectional view (cross-sectional view taken along line LXI-LXI in FIG. 60) showing an assembly according to an eighth modified example of the second embodiment. FIG. [Figure 62] FIG. 13 is a perspective view showing a liquid storage container according to a ninth modified example of the second embodiment. [Figure 63] 63 is a partial cross-sectional view (cross-sectional view taken along line LXIII-LXIII in FIG. 62) showing a liquid storage container according to a ninth modified example of the second embodiment. FIG. [Figure 64] FIG. 13 is a cross-sectional view showing an assembly according to a ninth modified example of the second embodiment. [Figure 65] FIG. 19 is a perspective view showing an assembly according to a tenth modified example of the second embodiment. DETAILED DESCRIPTION OF THE INVENTION

[0029] An embodiment will be described in detail below with reference to the drawings. The figures shown below are schematic illustrations. Therefore, the size and shape of each part are appropriately exaggerated for ease of understanding. Furthermore, appropriate modifications can be made within the scope of the technical concept. In the figures shown below, identical parts are denoted by the same reference numerals, and some detailed descriptions may be omitted. Furthermore, the numerical values, such as dimensions, and material names of each component described in this specification are merely examples of an embodiment and are not limited thereto. They may be selected and used as appropriate. In this specification, terms specifying shapes or geometric conditions, such as parallel, orthogonal, and vertical, are intended to include not only their strict meanings but also substantially the same state. For convenience of explanation, the terms "upper" and "lower" may be used, but the up-down direction may be reversed.

[0030] In this specification, when a certain component, region, or other structure is said to be "on (or under)" another component, region, or other structure, unless otherwise specified, this includes not only the case where it is directly above (or directly below) the other structure, but also the case where it is above (or below) the other structure, i.e., the case where another component is included between the other structure and above (or below) the other structure.

[0031] (First embodiment) The first embodiment will be described below with reference to FIGS.

[0032] [Liquid storage container] First, the configuration of a liquid storage container according to the present embodiment will be described with reference to Figures 1 to 3. Figure 1 is a perspective view showing a liquid storage container 10 according to the present embodiment, Figure 2 is a front view showing the liquid storage container 10 according to the present embodiment, and Figure 3 is a cross-sectional view showing the liquid storage container 10 according to the present embodiment.

[0033] 1 to 3, a liquid storage container 10 includes a container body 11 capable of storing liquid, and a sealing portion 20 formed at one end (first side end) of the container body 11. The container body 11 has a cylindrical body 12 and a connecting portion 13 formed continuously between the body 12 and the sealing portion 20. A sealing line 21 is formed between the connecting portion 13 and the sealing portion 20, and first corner portions 22, 23 are formed by the sealing line 21 and the connecting portion 13 at both ends of the sealing line 21. When viewed from a direction normal to an imaginary plane Sf that is parallel to the main surface 20a of the sealing portion 20 and includes the sealing line 21, the first corner portions 22, 23 all have angles θ1, θ2 of 50° or less.

[0034] Next, the detailed configuration of the liquid storage container 10 will be further described.

[0035] As described above, the container body 11 contains a liquid and has a cylindrical body 12 and a connecting portion 13 formed continuously between the body 12 and the sealed portion 20. The body 12 has a substantially cylindrical shape, and its horizontal cross section (a plane parallel to the XY plane) is substantially circular. The horizontal cross section of the body 12 is also substantially uniform along the vertical direction (Z direction). The horizontal cross section of the body 12 is not limited to a circle, but may be a polygon such as a square or hexagon, or an ellipse. The connecting portion 13 is a cylindrical portion formed continuously from the body 12 to the sealed portion 20, and its horizontal cross section gradually changes from the body 12 to the sealed portion 20. The body 12 and the connecting portion 13 are formed continuously and integrally with each other. In this embodiment, the container body 11 has a shape that is line-symmetrical left and right (in the X direction) when viewed from the front side (see FIG. 2).

[0036] The sealed portion 20 is a portion formed by sealing one end (the positive end in the Z direction) of the container body 11 by heat sealing or the like. Specifically, the sealed portion 20 is formed by crushing one end of a cylindrical member used to make the container body 11 and sealing the opposing inner surfaces of the end. The sealed portion 20 is generally planar, with its main surfaces being generally rectangular and parallel to the ZX plane. The sealed portion 20 is an area surrounded by an upper edge 24, a pair of side edges 25, 26, and a seal line 21, and this entire area is sealed. Examples of methods for sealing the sealed portion 20 include ultrasonic sealing, heat sealing, and high-frequency sealing. Alternatively, the inner surface of the container body 11 may be sealed by applying an adhesive. In this embodiment, a sealing method without using an adhesive is preferred because it can prevent the adhesive from being mixed into the liquid. In this specification, the "normal direction of the imaginary plane Sf" refers to the direction (Y direction) parallel to the main surface (surface parallel to the ZX plane) 20a of the sealing portion 20 and perpendicular to the imaginary plane Sf including the seal line 21 (see Figure 2).

[0037] The other end (second side end, negative end in the Z direction) of the container body 11 constitutes a closed removal section 30. During use, the liquid stored inside the container body 11 is removed from this removal section 30. The removal section 30 is made of a plate-like member that is approximately circular in a plan view. A thin-walled section 31 is provided in a part of the removal section 30 (see FIG. 3), and the liquid can be easily sucked from the liquid storage container 10 by piercing this thin-walled section 31 with a syringe needle or the like and sucking the liquid.

[0038] A flat stand 33 that supports the container body 11 is connected to the removal part 30 via a connecting part 32. The connecting parts 32 are made of thin, rod-like members that can be easily broken, and a plurality of connecting parts 32 are provided at predetermined intervals around the circumference of the removal part 30. In this embodiment, the connecting parts 32 are formed in two locations at equal intervals of 180°. The stand 33 forms the bottom of the liquid storage container 10, is formed in a generally diamond shape in a plan view, and is connected to the removal part 30 of the container body 11 via the connecting part 32. The stand 33 is positioned parallel to the XY plane.

[0039] Such a liquid storage container 10 is formed, for example, by integral molding with the end where the sealing portion 20 is provided left open, and is formed by heat-sealing the open end (i.e., forming the sealing portion 20) after filling the container body 11 with liquid. The liquid storage container 10 can be positioned so that the sealing portion 20 faces vertically upward and the stand portion 33 faces vertically downward.

[0040] When using the liquid storage container 10, the connecting portion 32 is broken to remove the stand portion 33, and a syringe needle is inserted into the thin-walled portion 31 of the extraction portion 30 to aspirate the liquid, thereby allowing the liquid to be extracted from the container body 11. Alternatively, the connecting portion 32 and the stand portion 33 may not be provided. In this case, for example, the container body 11 may be cut horizontally (in a direction parallel to the XY plane) to remove the extraction portion 30 side, and the liquid may be extracted from the liquid storage container 10. The method for extracting the liquid is not particularly limited, and examples include a method of aspirating the liquid using a syringe or the like. Alternatively, the liquid may be extracted from the liquid storage container 10 by opening the extraction portion 30 side of the container body 11, attaching a lid (not shown), and removing the lid. The liquid may be extracted by aspirating the liquid using a syringe or the like, as described above. Alternatively, the liquid may be aspirated by inserting a syringe into the lid while it is still attached.

[0041] The sealing line 21 is formed between the connecting portion 13 and the sealed portion 20, and is a line that constitutes the boundary between the sealed portion 20 and the container body 11. In the liquid storage container 10 shown in FIGS. 1 to 3, the sealing line 21 is straight and parallel to the horizontal direction (X direction). However, the sealing line 21 is not limited to this, and may be a curve with a predetermined curvature, or a curve whose curvature changes along the length of the sealing line 21. Furthermore, as will be described later, the sealing line 21 may be bent along the way (see FIGS. 13 and 15).

[0042] At both ends of the sealing line 21 (the positive end in the X direction and the negative end in the X direction), the sealing line 21 and the connecting portion 13 form first corners 22 and 23, respectively. That is, the first corner 22 is a corner formed by the end point of the sealing line 21 on the side edge 25 side, extending from the apex, and the side edge of the connecting portion 13. The first corner 23 is a corner formed by the end point of the sealing line 21 on the side edge 26 side, extending from the apex, and the side edge of the connecting portion 13. In this case, the first corners 22 and 23 are symmetrical to each other when viewed from the front. The first corners 22 and 23 at both ends of the sealing line 21 form predetermined angles θ1 and θ2 between the sealing line 21 and the connecting portion 13. The angles θ1 and θ2 of the first corner portions 22 and 23 are angles formed between the sealing line 21 and the connecting portion 13 at both ends of the sealing line 21 when the liquid storage container 10 is viewed from the normal direction of the imaginary plane Sf, and are angles on the inside of the container body 11. A specific method for measuring these angles will be described later. In the embodiment shown in Figures 1 to 3, the angles θ1 and θ2 of the first corner portions 22 and 23 are both 50° or less.

[0043] When the liquid storage container 10 is viewed from the normal direction of the imaginary plane Sf, the first corner portions 22, 23 each have an angle of 50° or less. This causes a convex meniscus to form inside the first corner portions 22, 23 when the liquid is removed from the liquid storage container 10. This prevents the liquid from penetrating deep into the first corner portions 22, 23, preventing the liquid from remaining inside the first corner portions 22, 23, and enabling the liquid to be removed efficiently from the liquid storage container 10. For example, as shown in FIG. 4 , when the liquid storage container 10 is viewed from the normal direction of the imaginary plane Sf, the first corner portion 22 has an angle θ1 of 50° or less. This causes the convex meniscus M formed on the surface of the liquid Lq to be positioned away from the first corner portion 22. This prevents the liquid Lq from reaching the first corner portion 22, making it less likely for the liquid Lq to remain inside the first corner portion 22.

[0044] Furthermore, for first corner portions 22, 23 that form an angle of 50° or less when viewed from the normal direction of imaginary plane Sf of the liquid storage container 10, when these first corner portions 22, 23 are observed from a direction parallel to imaginary plane Sf and perpendicular to the sealing line 21, the angle formed by the container body 11 at the first corner portions 22, 23 is preferably 35° or less. FIG. 5 is a view of the liquid storage container 10 shown in FIGS. 1 to 3 as viewed from a direction parallel to imaginary plane Sf and perpendicular to the sealing line 21. As shown in FIG. 5, the angle θ3 formed by the sealed container body 11 at the first corner portion 23 is preferably 35° or less. In this embodiment, the angle may be, for example, 30° or less or 20° or less. On the other hand, the angle may be, for example, 5° or more. By having the angle θ3 formed by the container body 11 at the first corner portion 23 be 35° or less, liquid remaining at the first corner portion 23 can be effectively prevented. Here, the angle θ3 of the first corner portion 23 when observed parallel to the imaginary plane Sf and perpendicular to the sealing line 21 is the angle formed between the first corner portion 23 and the outer surface of the container body 11 when viewed from a direction parallel to the imaginary plane Sf and perpendicular to the sealing line 21, and a specific measurement method will be described later. Note that, although not shown, the angle θ3 formed by the first corner portion 22 and the container body 11 is similarly preferably 35° or less.

[0045] According to the present embodiment, when removing liquid from the liquid storage container 10, residual liquid in the liquid storage container 10 can be reduced. Generally, removing liquid from a liquid storage container involves inserting a syringe needle into the removal portion and aspirating the liquid, or removing a lid member inserted into the removal portion and removing the liquid. When removing liquid in this manner, it is common to tilt the liquid storage container so that the removal portion faces downward, allowing the liquid to pool near the removal portion. However, it has been found that this can result in liquid remaining in the first corner portion, which is located at the boundary between the sealed portion and the container body, making it difficult to remove the liquid from the removal portion. This problem is particularly pronounced when the liquid stored in the liquid storage container is expensive or when all of the liquid stored in the liquid storage container must be administered. To address this problem, for example, inserting a syringe needle into the first corner portion where the liquid remains from the removal portion and aspirating the remaining liquid is conceivable. However, depending on the length of the syringe needle, it may not be able to reach the liquid remaining in the first corner portion. After extensive research, the inventors discovered that this problem can be solved by adjusting the angle of the first corner portion where liquid remains. This embodiment was developed based on this finding. The problem can be solved by either having all of the first corner portions at an angle of 50° or less when the liquid container is viewed from the normal direction of the imaginary plane, or by having both first corner portions at an angle of 100° or more and first corner portions at an angle of 50° or less, as described below. It is preferable to use an injection needle that can reduce the occurrence of coring (a phenomenon in which part of the extraction portion is scraped off by the injection needle) during liquid aspiration and, if the liquid is a cell preparation, that causes minimal damage to the cells. Specifically, a Safeby Access (Nippon Covidien Co., Ltd.) or an 18G (outer diameter: 1.2 mm) injection needle may be used. Specifically, when cells are aspirated using a thin-diameter needle (e.g., 22G (outer diameter: 0.7 mm)), they are aspirated into a narrow tube, which may result in cell damage due to stress caused by the aspiration pressure.On the other hand, when a thicker diameter needle (for example, 18G (outer diameter: 1.2 mm)) is used, the cells are sucked into a thick tube, so the stress caused by the suction pressure is small and damage to the cells can be suppressed. This embodiment can be applied even more effectively to liquid storage containers in which the injection needle does not reach the first corner when inserted into the extraction part.

[0046] The material constituting the container body 11 may be any material that can be sealed. Furthermore, the material constituting the container body 11 is preferably a material that does not affect the liquid when it comes into contact with the liquid, and is appropriately selected depending on the type of liquid contained in the liquid storage container 10. Furthermore, the material constituting the container body 11 is also appropriately selected depending on the application of the liquid storage container 10. Specifically, when it is desired to impart predetermined properties to the liquid storage container 10, such as strength, flexibility, water vapor permeability, heat resistance, or light transmittance, it is preferable to appropriately select a material that has such properties. Such materials can be similar to materials used in general resin liquid storage containers, and examples include flexible resin materials. Specific examples include various resins such as polyvinyl chloride, polyethylene (PE), polypropylene (PP), polybutadiene, cyclic polyolefins, polypropylene homopolymers, polyolefins such as high-density polyethylene, polystyrene, poly-(4-methylpentene-1), polycarbonate, ABS resin, acrylic resin, polymethyl methacrylate (PMMA), polyacetal, polyarylate, polyacrylonitrile, polyvinylidene fluoride, ionomers, acrylonitrile-butadiene-styrene copolymers, polyethylene-styrene copolymers, ethylene-vinyl acetate copolymers (EVA), aromatic or aliphatic polyamides, and mixtures of any combinations of these.

[0047] The container body 11 preferably has a predetermined liquid-repellent property against the liquid. Therefore, the liquid-repellent property of the inner surface of the container body 11 is preferably adjusted appropriately depending on the type of liquid contained in the liquid storage container 10. Specifically, the contact angle of the inner surface of the container body 11 with the liquid may be, for example, 20° or more, preferably 40° or more, more preferably 70° or more, and particularly preferably 80° or more. The contact angle of the inner surface of the container body 11 with the liquid may be the contact angle with water unless there are special circumstances. The contact angle can be measured according to the θ / 2 method, in which the inner surface of the container body is exposed, a 1.0 μl droplet of liquid or pure water is dropped on the exposed inner surface, and 10 seconds after the droplet lands, the contact angle is calculated from the angle of a line connecting the left and right endpoints of the dropped droplet to the vertex relative to the solid surface. For example, a contact angle meter DM 500 manufactured by Kyowa Interface Science Co., Ltd. can be used as the measuring device.

[0048] The method for imparting predetermined liquid repellency to the container body 11 is not particularly limited and can be appropriately selected depending on the material constituting the container body 11. For example, the liquid repellency may be imparted by irradiating the container body 11 with energy rays, or a material that imparts liquid repellency may be added to the material constituting the container body 11, or the inner surface of the container body 11 may be surface coated with a material that imparts liquid repellency. Examples of the energy rays include light rays such as far ultraviolet rays, ultraviolet rays, near ultraviolet rays, and infrared rays, electromagnetic waves such as X-rays and gamma rays, as well as electron beams, proton beams, and neutron beams. Among these, gamma rays are preferred.

[0049] The characteristics of the container body 11, such as thickness, strength, light transmittance, heat resistance, and gas barrier properties, can be adjusted appropriately depending on the use of the liquid storage container 10 and the type of liquid stored in the container, so they will not be described here.

[0050] The container body 11 may have a single-layer structure or a multi-layer structure. When the container body 11 has a multi-layer structure, only the inner surface of the container body 11 may be made of the resin material described above, and the other layers may have an aluminum layer containing aluminum. Furthermore, the outer surface of the container body 11 may be surface-coated with a material such as silica, if necessary. In this case, barrier properties can be imparted to the liquid storage container 10.

[0051] The liquid to be stored in the liquid storage container 10 according to this embodiment is not particularly limited, but it is particularly effective to use the liquid storage container 10 according to this embodiment for, for example, expensive liquids or liquids for which the amount to be administered is strictly regulated, etc. In other words, since it is possible to prevent liquid from remaining in the liquid storage container 10, it is easier to remove the liquid than before.

[0052] The liquid contained in the liquid storage container 10 may be a medicinal solution such as a pharmaceutical product. Specific examples of such medicinal solutions include antirheumatic drugs, insulin preparations, sugar solutions such as glucose, electrolyte correction solutions such as sodium chloride and potassium lactate, protein preparations, antibody drugs, contrast agents, protease inhibitors, fat emulsions, antibiotics, anticancer drugs, heparin calcium anesthetics, and peritoneal dialysis solutions. Other examples include so-called premixed preparations prepared by dissolving preparations such as analgesics, antipyretics, antiemetics, antitussives, antihistamines, antiallergic drugs, bronchodilators, steroids, antiarrhythmic drugs, and antiepileptic drugs in sterile water such as RO water or distilled water or physiological saline. Furthermore, the medicinal solution may be a biological medicine such as vaccines for influenza, tetanus, pneumococcus, polio, Japanese encephalitis, rubella, measles, yellow fever, Hib, hepatitis, chickenpox, rabies, rotavirus, mumps, cervical cancer, MQ, DT, and DPT. Furthermore, biological cells such as bone marrow cells and lymphocytes may also be used. The medicinal solution may also be, for example, a cell preparation, specifically, hepatoma cells, hepatocytes (liver parenchymal cells), Kupffer cells, endothelial cells such as vascular endothelial cells and corneal endothelial cells, fibroblasts, osteoblasts, osteoclasts, periodontal ligament-derived cells, epidermal cells such as epidermal keratinocytes, epithelial cells such as tracheal epithelial cells, gastrointestinal epithelial cells, cervical epithelial cells, and corneal epithelial cells, mammary gland cells, pericytes, muscle cells such as smooth muscle cells and cardiac muscle cells, kidney cells, pancreatic islet cells of Langerhans, nerve cells such as peripheral nerve cells and optic nerve cells, chondrocytes, bone cells, or stem cells, ES cells (embryonic stem cells), iPS cells (induced pluripotent stem cells), etc. Examples of stem cells include bone marrow undifferentiated mesenchymal stem cells, hematopoietic stem cells, vascular stem cells, neural stem cells, small intestinal stem cells, adipose stem cells, skin stem cells, periodontal tissue stem cells, ciliary body stem cells, corneal limbal stem cells, and visceral stem cells.

[0053] Alternatively, the liquid contained in the liquid container 10 may be a food-related liquid, specifically a liquid such as a beverage or seasoning.

[0054] The liquid container 10 according to this embodiment can be used, for example, as a medical container or a food container for storing the liquid as described above.

[0055] [Operation of this embodiment] Next, the operation of this embodiment having the above-described configuration will be described.

[0056] First, the container body 11 is produced by integral molding with one end where the sealed portion 20 is provided left open. Next, a predetermined amount of liquid Lq is filled into the container body 11, and the open end is heat-sealed to form the sealed portion 20. This results in a liquid-filled container 40 comprising the liquid storage container 10 and the liquid Lq stored in the liquid storage container 10 (see FIG. 6). In this embodiment, such a liquid-filled container 40 is also provided.

[0057] When in use, first, the liquid-filled container 40 described above is prepared. Next, the connecting portion 32 is broken, and the stand portion 33 is removed from the container body 11. Next, an opening communicating with the interior is formed in the container body 11, and the liquid Lq in the container body 11 is removed through this opening. For example, as shown in FIG. 6 , a syringe needle 45 may be inserted into the outlet portion 30 of the liquid-filled container 40 to form an opening 34 in the outlet portion 30, and the syringe needle 45 inserted into this opening 34 may be used to aspirate the liquid Lq and remove the liquid Lq from the container body 11. This allows the liquid Lq to be removed from the container body 11 without waste, even when the liquid Lq is an expensive medicinal liquid, which is economical. Furthermore, a precise amount of medicinal liquid can be extracted from the container body 11. In this embodiment, a method for producing such a predetermined amount of medicinal liquid is also provided.

[0058] In this embodiment, when the liquid storage container 10 is viewed from the normal direction of the imaginary plane Sf, the angles θ1 and θ2 of the first corner portions 22 and 23 are all 50° or less. Therefore, a convex meniscus M is formed inside the first corner portions 22 and 23 (see the circled area in FIG. 6 ). This makes it difficult for the liquid Lq to penetrate deep into the first corner portions 22 and 23, even when the liquid storage container 10 is oriented such that the sealing portion 20 faces vertically downward. This prevents the liquid Lq from penetrating inside the first corner portions 22 and 23, and prevents the liquid Lq from remaining inside the first corner portions 22 and 23. This allows the liquid Lq to be extracted from the liquid storage container 10 without waste when the syringe needle 45 is inserted and the liquid Lq is aspirated. On the other hand, if the angle of the first corner portion 101 when the liquid storage container 100 is viewed from the normal direction of the imaginary plane is greater than 50° and less than 100°, the above-mentioned convex meniscus will not be formed, and the liquid Lq will remain inside the first corner portion 101 (see FIG. 20). In this case, it may be difficult to remove the liquid Lq from the liquid storage container 100 without waste. For this reason, it is preferable that there are no first corner portions on the sealing line 21 or on both ends of the sealing line 21 that are greater than 50° and less than 100° when viewed from the normal direction of the imaginary plane Sf.

[0059] [Variations] Next, various modified examples of the present disclosure will be described with reference to Figures 7 to 16. Figures 7 to 16 are views showing liquid storage containers according to various modified examples of the present disclosure. In Figures 7 to 16, the same parts as those shown in Figures 1 to 6 are designated by the same reference numerals, and detailed descriptions thereof will be omitted.

[0060] (First Modification) Figures 7 to 9 show a liquid storage container 10A according to a first modified example. In Figures 7 to 9, unlike the liquid storage container 10 shown in Figures 1 to 6, the container body 11 has an asymmetric shape in the left-right direction (X direction) when viewed from the front side (Figure 8).

[0061] 7 and 8, the liquid storage container 10A includes a container body 11 capable of storing liquid, and a sealing portion 20 formed at one end of the container body 11. The container body 11 has a cylindrical body 12 and a connecting portion 13 formed continuously between the body 12 and the sealing portion 20. A sealing line 21 is formed between the connecting portion 13 and the sealing portion 20, and first corner portions 22A, 23A are formed at both ends of the sealing line 21 by the sealing line 21 and the connecting portion 13, respectively. In this case, when the liquid storage container 10A is viewed from the normal direction of the imaginary plane Sf, the first corner portions 22A, 23A have both the first corner portion 22A at an angle θ4 of 100° or more and the other first corner portion 23A at an angle θ5 of 50° or less.

[0062] The sealing portion 20 is generally planar, with its main surfaces forming a generally parallelogram parallel to the ZX plane. The sealing line 21 is linear and extends at an angle relative to the horizontal direction (X direction). The sealing line 21 has one first corner portion 22A and the other first corner portion 23A at each end. In this case, the first corner portions 22A and 23A have asymmetric shapes relative to each other when viewed from the front. One first corner portion 22A is located lower (toward the negative Z direction) than the other first corner portion 23A.

[0063] When the liquid storage container 10A is viewed from the normal direction of the imaginary plane Sf, the one first corner portion 22A has an angle θ4 of 100° or more. In this case, when the liquid storage container 10A filled with liquid is tilted, for example, so that the sealed portion 20 faces vertically downward, the liquid enters the one first corner portion 22A. When the liquid storage container 10A is then turned so that the sealed portion 20 faces vertically upward, the liquid that entered the one first corner portion 22A flows out from the one first corner portion 22A. This prevents the liquid from remaining inside the one first corner portion 22A. As a result, the liquid in the container body 11 can be removed without waste.

[0064] Furthermore, when the liquid storage container 10A is viewed from the normal direction of the imaginary plane Sf, the other first corner portion 23A has an angle θ5 of 50° or less. This causes a convex meniscus to be formed inside the other first corner portion 23A, preventing the liquid from penetrating deep into the other first corner portion 23A and preventing the liquid from remaining inside the other first corner portion 23A.

[0065] Furthermore, according to this modification, since the sealing line 21 extends at an angle in the horizontal direction (X direction), a wide area can be ensured for the sealed portion 20, and the peel strength of the sealed portion 20 can be increased. Also, according to this modification, by filling the liquid with liquid in a tilted state before sealing, as shown in Fig. 9, for example, it is possible to prevent air bubbles from being generated in the liquid during filling. This makes it possible to prevent air bubbles from adversely affecting cells, for example, when a cell suspension is used as the liquid.

[0066] As shown in FIG. 10 , in the liquid storage container 10A according to this modification, the sealing line 21 may have an arc shape that curves toward the upper edge 24 when viewed from the normal direction of the imaginary plane Sf. In this case, the circle that constitutes the sealing line 21 preferably has a predetermined radius of curvature R that satisfies the following condition. In FIG. 10 , point O is the center of the circle that constitutes the sealing line 21. Line La is a line connecting the first corner portion 22A and point O, line Lb is a line connecting the first corner portion 23A and point O, and line Lc is a line connecting the first corner portions 22A and 23A. Angle α1 is the angle between line Lc and the side edge 11a of the container body 11, and angle β1 is the angle between line La and line Lc. Angle α2 is the angle between line Lc and the side edge 11b of the container body 11, and angle β2 is the angle between line Lb and line Lc.

[0067] At this time, the radius of curvature R of the seal line 21 for the first corner portion 22A is R = length of line Lc / 2cosβ1 (A) Here, since the angle θ4 is 100° or more, 100°≦θ4<180° (1) In addition, since θ4 can be approximated to the angle between the tangent Ld at the first corner portion 22A of the circle centered at the point O and the side edge 11a of the container body 11, the angle β1 can be expressed as follows: β1=α1-(θ4-90°) (2) From (1) and (2), the angle β1 is α1-90°<β1≦α1-10°···(3) Furthermore, in this modification, α1>0 (4) 0°≦β1<90° (5) Therefore, when the angles α1 and β1 for R are within the range of formula (A) that satisfies the regions (3), (4), and (5) (see FIG. 11), the effect of suppressing liquid from remaining inside the first corner portion 22A can be suitably obtained.

[0068] Furthermore, for the first corner portion 23A, the radius of curvature R of the circle that constitutes the seal line 21 is R = length of line Lc / 2cosβ2 (B) Here, since the angle θ5 is 50° or less, 0°<θ5≦50° (6) In addition, since θ5 can be approximated as the angle between the tangent Le at the first corner portion 23A of the circle centered at the point O and the side edge 11b of the container body 11, the angle β2 is given by β2=(90°-θ5)+α2 (7) From (6) and (7), the angle β2 is 40°+α2≦β2<90°+α2···(8) Furthermore, in this modification, α2>0 (9) 0°≦β2<90° (10) Therefore, when the angles α2 and β2 for R are within the range of formula (B) that satisfies the regions (8), (9), and (10) (see FIG. 12), the effect of suppressing liquid from remaining inside the first corner portion 23A can be suitably obtained.

[0069] (Second Modification) FIG. 13 shows a liquid storage container 10B according to a second modified example. In FIG. 13, first corner portions 22B and 23B are formed by the sealing line 21 and the connecting portion 13 at both ends of the sealing line 21, and a second corner portion 27B is formed midway along the sealing line 21. In this case, the first corner portions 22B and 23B located at both ends of the sealing line 21 have angles θ6 and θ7 of 50° or less when the liquid storage container 10B is viewed from the normal direction of the imaginary plane Sf. Meanwhile, the second corner portion 27B is located between the first corner portion 22B and the first corner portion 23B, at the center of the sealing line 21 in the longitudinal direction. The angle θ8 of this second corner portion 27B is 100° or more when the liquid storage container 10B is viewed from the normal direction of the imaginary plane Sf. In this way, when the liquid storage container 10B is viewed from the normal direction of the imaginary plane Sf, by having both the second corner portion 27B having an angle θ8 of 100° or more and the first corner portions 22B, 23B having angles θ6, θ7 of 50° or less, it is possible to make it difficult for liquid to remain inside the first corner portions 22B, 23B and the second corner portion 27B. Furthermore, according to this modification, since the seal line 21 extends in a substantially V-shape, it is possible to ensure a wide area for the sealed portion 20 and increase the peel strength of the sealed portion 20.

[0070] 14, for a second corner portion 27B that forms an angle of 100° or more when the liquid storage container 10B is viewed from the normal direction of the imaginary plane Sf, when the second corner portion 27B is cut on a plane perpendicular to the sealing line 21, the angle θ12 formed by the container body 11 at the second corner portion 27B is preferably 40° or more. On the other hand, the angle θ12 can be set to, for example, 150° or less. When the second corner portion 27B is cut on a plane perpendicular to the sealing line 21, by the angle θ12 formed by the container body 11 being 40° or more, it is possible to effectively prevent liquid from remaining at the second corner portion 27B.

[0071] (Third Modification) Fig. 15 shows a liquid storage container 10C according to a third modified example. In Fig. 15, first corner portions 22C and 23C are formed by the sealing line 21 and the connecting portion 13 at both ends of the sealing line 21, and a second corner portion 27C is formed midway along the sealing line 21. In this case, the first corner portions 22C and 23C located at both ends of the sealing line 21 have angles θ9 and θ10 of 100° or more when the liquid storage container 10C is viewed from the normal direction of the imaginary plane Sf. On the other hand, the second corner portion 27C is located at the center of the sealing line 21 in the longitudinal direction. The angle θ11 of this second corner portion 27C is 50° or less when the liquid storage container 10C is viewed from the normal direction of the imaginary plane Sf. In this way, when the liquid storage container 10C is viewed from the normal direction of the imaginary plane Sf, by having both the first corner portions 22C, 23C having angles θ9, θ10 of 100° or more and the second corner portion 27C having an angle θ11 of 50° or less, it is possible to make it difficult for liquid to remain inside the first corner portions 22C, 23C and the second corner portion 27C. Furthermore, according to this modification, since the seal line 21 extends in a substantially V-shape, it is possible to ensure a wide area for the sealed portion 20 and increase the peel strength of the sealed portion 20.

[0072] (Fourth Modification) Fig. 16 shows a liquid storage container 10D according to a fourth modification. As shown in Fig. 16, the liquid storage container 10D has a liquid packaging bag 50 that is provided to communicate with the removal section 30. In this case, for example, the liquid may be removed by cutting the container body 11, or the liquid packaging bag 50 may have a liquid removal means as indicated by the reference numeral 51. In Fig. 16, the liquid removal means 51 includes a tube 52 and a liquid collection needle 53 connected to the tip of the tube 52, but this is not particularly limited, and any known liquid removal means may be used. Here, "communicating" means that the liquid can be transferred from the liquid packaging bag 50 through the removal section 30 to the sealed section 20.

[0073] This liquid storage container 10D can be used as, for example, a cell culture bag for storing biological cells, a cell cryopreservation bag for storing and cryopreserving biological cells, a blood bag for storing blood or blood components, an IVH bag for storing nutrients for direct administration to a central vein, etc., an infusion bag for storing liquid for intravenous drip, a bag for storing enteral nutrients, and various other bags for storing various liquids. According to this modification, for example, when administering intravenous drip or the like from the liquid removal means 51, it is possible to reduce the amount of liquid remaining in the sealed portion 20 of the container body 11.

[0074] [Method for Measuring the Angle of the First Corner Portion When the Liquid Storage Container is Viewed from the Normal Direction of the Imaginary Plane] Next, a method for measuring the angle of the first corner portion when the liquid storage container is viewed from the normal direction of the imaginary plane will be described.

[0075] First, with the liquid storage container 10 filled with liquid, the sealed portion 20 of the liquid storage container 10 is positioned opposite the lens of a microscope device (manufactured by KEYENCE Corporation, lens: VH-Z50L). At this time, the microscope device is positioned so that the optical axis of the lens is perpendicular to the seal line 21. Next, the first corner portions 22, 23 to be measured are observed using the microscope device (observation magnification: lens Z50×50x). Note that the method of observing the first corner portions 22, 23 is not limited to measurement using a microscope device, and may also be, for example, observation using a stereomicroscope, photography with a camera, etc.

[0076] 17(a)-(c) show images of the first corner portions 22 and 23 observed with a microscope. Next, while observing the images of the first corner portions 22 and 23 with the microscope, the following operations are performed.

[0077] First, as shown in Figure 17(a), a line L1 3 mm long is drawn based on the side edge E1 of the container body 11. Line L1 has points b and d at both ends, with point d positioned on the side edge E1. Note that the portion (denoted by symbol P1) formed between the container body 11 and the sealed portion 20 when the sealed portion 20 is formed is not included in the side edge E1.

[0078] 17(b), a straight line L2 3 mm in length is drawn based on the seal line 21. The line L2 has points a and c at both ends, with point c positioned on the seal line 21 and point a positioned outside the seal line 21 (towards the sealed portion 20).

[0079] 17(c), the lines L1 and L2 are translated so that point d is located on the side edge E1, point c is located on the seal line 21, and points a and b overlap. The angle θa formed by the lines L1 and L2 at this time is defined as the angle of the first corner portions 22, 23 when the liquid storage container 10 is viewed from the normal direction of the imaginary plane.

[0080] [Method for measuring the angle formed by the container body when observing the first corner parallel to an imaginary plane and perpendicular to the seal line] Next, a method for measuring the angle formed by the container body when the first corner portion is observed parallel to the imaginary plane and perpendicular to the seal line will be described.

[0081] (When the first corner of the liquid container is at an angle of less than 90° when viewed from the normal direction of the imaginary plane) First, we will explain how to measure the angle formed by the container body when observing a first corner portion of a liquid storage container that has an angle of less than 90° when viewed from the normal direction of an imaginary plane, parallel to the imaginary plane and perpendicular to the seal line.

[0082] First, as shown in FIG. 18(a), the liquid storage container 10A is filled with liquid and positioned so that the seal line 21 of the liquid storage container 10A is perpendicular to the optical axis A1 of the lens of a microscope device (manufactured by KEYENCE Corporation, lens: VH-Z50L) 60. Next, the real-time depth stacking function of the microscope device 60 is used to observe the first corner portion 23A to be measured (observation magnification: lens Z50×50x). FIGS. 18(b)-(d) show images of the first corner portion 23A observed by the microscope device 60. Note that the method of observing the first corner portion 23A is not limited to measurement using a microscope device, and may also be, for example, observation with a stereomicroscope, photography with a camera, or the like.

[0083] Next, as shown in Figure 18(b), two straight lines L3 and L4, each 3 mm long, are drawn connecting the tip point P2 of the container body 11 and the side edges E2 and E3 of the container body 11, and a bisector L5 is drawn for the angle formed by these straight lines L3 and L4.

[0084] Next, as shown in FIG. 18(c), a perpendicular line L6 perpendicular to the bisector L5 is drawn at a position on the bisector L5 that is 3 mm away from the tip point P2 of the container body 11.

[0085] Then, as shown in Figure 18(d), two intersection points P3 and P4 between the perpendicular line L6 and the side edges E2 and E3 of the container body 11 are determined, and the angle θb between these intersection points P3 and P4 and the tip point P2 of the container body 11 is defined as the angle formed by the container body 11 when the first corner portion 23A is observed parallel to the imaginary plane Sf and perpendicular to the seal line 21.

[0086] (When the first corner of the liquid container is at an angle of 90° or more when viewed from the normal direction of the imaginary plane) First, we will explain how to measure the angle formed by the container body when observing a first corner portion of a liquid storage container that has an angle of 90° or more when viewed from the normal direction of an imaginary plane, parallel to the imaginary plane and perpendicular to the seal line.

[0087] First, as shown in FIG. 19(a), the sealed portion 20 around the first corner portion 22A to be observed is cut away along the seal line 21 of the liquid container 10A. Next, the liquid container 10A is filled with liquid and positioned so that the seal line 21 of the liquid container 10A is perpendicular to the optical axis A1 of a microscope device 60 (manufactured by KEYENCE Corporation, lens: VH-Z50L). Since a portion of the sealed portion 20 has been cut away, the seal line 21 can be observed using the microscope device 60. Next, the first corner portion 22A to be measured is observed using the real-time depth stacking function of the microscope device 60 (observation magnification: lens Z50×50x). FIGS. 19(b)-(d) show images of the first corner portion 22A observed using the microscope device 60. Note that the method of observing the first corner portion 22A is not limited to measurement using a microscope device, and may also be, for example, observation using a stereomicroscope or photography with a camera.

[0088] Next, as shown in FIG. 19(b), a straight line L7 parallel to the seal line 21 is drawn from the tip point P5 of the container body 11.

[0089] Next, as shown in FIG. 19(c), a perpendicular line L8 perpendicular to the line L7 is drawn at a position 3 mm away from the tip point P5 of the container body 11 on the line L7.

[0090] Then, as shown in Figure 19(d), two intersection points P6 and P7 between the perpendicular line L8 and the side edges E4 and E5 of the container body 11 are found, and the angle θc between these intersection points P6 and P7 and the tip point P5 of the container body 11 is defined as the angle formed by the container body 11 when the first corner portion 22A is observed parallel to the imaginary plane Sf and perpendicular to the seal line 21.

[0091] [Example] Next, a specific example of this embodiment will be described.

[0092] (Examples 1 to 4, Comparative Examples 1 to 4) Liquid storage containers (Examples 1 to 4, Comparative Examples 1 to 4) were produced by sealing (heat sealing) one end of a container body (made of polyethylene) to form a sealed portion and the other end to form a removal portion. At this time, the angles of the two first corner portions formed on both ends of the seal line were adjusted. The diameter of the body of the container body of each liquid storage container was 10 mm to 12 mm, and the height of each liquid storage container was 40 mm to 43 mm.

[0093] (Rating 1) Water, cryopreservation solution, or disinfectant ethanol was placed in each of the liquid storage containers obtained in Examples 1 to 4 and Comparative Examples 1 to 4, and the amount of liquid remaining at the two first corners formed on both ends of the seal line was evaluated. Specifically, the evaluation was performed as follows. The results are shown in Table 1. ◎ (Excellent): Less than 1 mg of liquid remains ○ (good): Remaining liquid is 1 mg or more but less than 10 mg × (poor): Remaining liquid is 10 mg or more

[0094] In the table, angles θx and θy indicate the angles of each first corner portion when the liquid storage container is viewed from the normal direction of the imaginary plane (angles corresponding to θ1 and θ2 in FIGS. 1 and 2, θ4 and θ5 in FIGS. 7 and 8, and θa in FIG. 17(c)). Also, angle θz indicates the average value of the angles (angles corresponding to θ3 in FIG. 5, θb in FIG. 18(d), and θc in FIG. 19(d)) formed by the container body at two first corner portions when observed parallel to the imaginary plane and perpendicular to the seal line (however, for Example 4, the angle shown is the angle formed by the container body at one first corner portion).

[0095] [Table 1]

[0096] As a result of evaluating the residual liquid in the liquid storage containers obtained in Examples 1 to 4 and Comparative Examples 1 to 4, as shown in Table 1, it was found that residual liquid in the first corner portions can be suppressed when all of the multiple first corner portions have angles of 50° or less, or when the container has both first corner portions with angles of 100° or more and first corner portions with angles of 50° or less.

[0097] Furthermore, when the contact angle of the liquid with respect to the liquid storage container is low (less than 20°), the liquid tends to flow easily within the liquid storage container, making it difficult for the liquid to remain in the first place. Therefore, it is believed that the effects of this embodiment are more likely to be obtained when the contact angle of the liquid with respect to the liquid storage container is high (20° or more).

[0098] (Examples 5 and 6, Comparative Examples 5 and 6) Liquid storage containers (Examples 5-6, Comparative Examples 5-6) were produced in the same manner as Examples 1-4 and Comparative Examples 1-4, except that the size of each liquid storage container was changed. At this time, the angles of the two first corner portions formed on both ends of the seal line were adjusted. The diameter of the barrel of the container body of each liquid storage container was 17 mm to 20 mm, and the height of each liquid storage container was 70 mm to 75 mm.

[0099] (Rating 2) Water, cryopreservation solution, or disinfectant ethanol was placed in each of the liquid storage containers obtained in Examples 5 and 6 and Comparative Examples 5 and 6, and the amount of liquid remaining at the two first corners formed on the seal line was evaluated. Specifically, the evaluation was performed in the same manner as in Evaluation 1 above. The results are shown in Table 2.

[0100] [Table 2]

[0101] As a result of evaluating the residual liquid in the liquid storage containers obtained in Examples 5 and 6 and Comparative Examples 5 and 6, as shown in Table 2, it was found that residual liquid in the first corner portions can be suppressed when all of the multiple first corner portions have angles of 50° or less, or when the container has both first corner portions with angles of 100° or more and first corner portions with angles of 50° or less.

[0102] [Reference example] A liquid storage container was produced in which a second corner portion was located at the longitudinal center of the seal line, as shown in Fig. 15. At this time, the angle of the second corner portion when the liquid storage container was viewed from the normal direction of the imaginary plane (the angle indicated by θ11 in Fig. 15) and the angle formed by the container body at the second corner portion when the liquid storage container was cut along a plane perpendicular to the seal line (the angle indicated by θ12 in Fig. 14) were adjusted to predetermined angles.

[0103] (Rating 3) Water or a cryopreservation solution was placed in each liquid storage container obtained in the reference example, and the amount of liquid remaining in the second corner portion was evaluated. Specifically, the evaluation was performed in the same manner as in Evaluation 1 above. The results are shown in Table 3.

[0104] [Table 3]

[0105] As a result, it was found that when the angle of the second corner portion when the liquid container is viewed from the normal direction of the imaginary plane (the angle shown by θ11 in FIG. 15) is 50°, liquid remaining at the second corner portion can be suppressed by setting the angle formed by the container body at the second corner portion when cut on a plane perpendicular to the seal line (the angle shown by θ12 in FIG. 14) to 25°. On the other hand, when the angle of the second corner portion when the liquid container is viewed from the normal direction of the imaginary plane (the angle shown by θ11 in FIG. 15) is 100° or more, liquid remaining at the second corner portion can be suppressed by setting the angle formed by the container body at the second corner portion when cut on a plane perpendicular to the seal line (the angle shown by θ12 in FIG. 14) to 40° or more.

[0106] (Second embodiment) Next, a second embodiment will be described with reference to Figures 21 to 65. Figures 21 to 65 are diagrams showing the second embodiment. In Figures 21 to 65, the same parts as those in the first embodiment shown in Figures 1 to 20 are given the same reference numerals, and detailed descriptions thereof will be omitted.

[0107] [Liquid storage container] First, with reference to FIG. 21, the configuration of a liquid container according to this embodiment will be described.

[0108] Fig. 21 shows a sealed liquid storage container 10E according to the present embodiment. As shown in Fig. 21, the liquid storage container 10E includes a container body 11 capable of storing liquid and a sealing portion 20 formed at one end (first side end) of the container body 11. The container body 11 has a cylindrical body 12 and a connecting portion 13 formed continuously between the body 12 and the sealing portion 20. A sealing line 21 is formed between the connecting portion 13 and the sealing portion 20, and first corner portions 22A, 23A are formed at both ends of the sealing line 21 by the sealing line 21 and the connecting portion 13, respectively. In this case, when the liquid storage container 10E is viewed from the normal direction of the imaginary plane Sf, the first corner portions 22A, 23A have one first corner portion 22A having an angle θ20 and the other first corner portion 23A having an angle θ21.

[0109] The sealing portion 20 is generally planar, with its main surfaces forming a generally parallelogram parallel to the ZX plane. The sealing line 21 is linear and extends at an angle relative to the horizontal direction (X direction). The sealing line 21 has one first corner portion 22A and the other first corner portion 23A at each end. In this case, the first corner portions 22A and 23A have asymmetric shapes relative to each other when viewed from the front. One first corner portion 22A is located lower (toward the negative Z direction) than the other first corner portion 23A.

[0110] When the liquid storage container 10E is viewed from the normal direction of the imaginary plane Sf, the angle θ20 of the one first corner portion 22A is an obtuse angle. This angle θ20 is preferably equal to or greater than 100°. When the liquid storage container 10E filled with liquid is tilted, for example, so that the sealed portion 20 faces vertically downward, the liquid enters the one first corner portion 22A. When the liquid storage container 10E is then tilted so that the sealed portion 20 faces vertically upward, the liquid that entered the one first corner portion 22A flows out from the one first corner portion 22A. This prevents the liquid from remaining inside the one first corner portion 22A. As a result, the liquid in the container body 11 can be removed without waste.

[0111] Furthermore, when the liquid storage container 10E is viewed from the normal direction of the imaginary plane Sf, the angle θ21 of the other first corner portion 23A is an acute angle. This angle θ21 is preferably 50° or less. When the angle θ21 is 50° or less, a convex meniscus is generated inside the other first corner portion 23A, which prevents the liquid from penetrating deep into the other first corner portion 23A and preventing the liquid from remaining inside the other first corner portion 23A.

[0112] 22 and 23 show the liquid storage container 10E before it is sealed by the sealing part 20. As shown in Figures 22 and 23, the liquid storage container 10E before it is sealed includes a cylindrical container body 11A having a sealable opening 15 provided at one end (first side end) and a closing part provided at the other end (second side end).

[0113] The container body 11A has an overall shape like a cylinder cut diagonally (like a syringe needle). The container body 11A is sealed by sealing the vicinity of the opening 15, forming the sealed portion 20 shown in Figure 21. This container body 11A constitutes the container body 11, body portion 12, connecting portion 13, and sealed portion 20 of the sealed liquid storage container 10E shown in Figure 21.

[0114] At least a portion of the peripheral edge 15a of the opening 15 is disposed on the opening surface Sa, and the peripheral edge 15a is inclined with respect to the central axis CL of the container body 11A. Here, "a portion of the peripheral edge 15a is disposed on the opening surface Sa" means that a portion of the peripheral edge 15a and the opening surface Sa overlap with each other via a line or a surface, and refers to a case where at least 10% or more of the area of ​​the peripheral edge 15a overlaps with the opening surface Sa. As shown in FIG. 23, the opening surface Sa is inclined with respect to the central axis CL of the container body 11A and intersects with the central axis CL without being perpendicular to the central axis CL. Furthermore, an imaginary line VL (FIG. 22) connecting the first end point (upper end) 15b and the second end point (lower end) 15c of the opening 15 of the peripheral edge 15a is inclined with respect to the central axis CL of the container body 11A. The central axis CL may be a straight line connecting the centers of gravity of the container body 11A in each horizontal cross section. Furthermore, when the container body 11A can be placed on a flat surface, the central axis CL may extend in a direction perpendicular to the flat surface. Note that the first end point 15b is the point of the opening 15 that is farthest from the closing portion, and the second end point 15c is the point of the opening 15 that is closest to the closing portion.

[0115] As shown in Fig. 23, when the container body 11A is projected parallel to an imaginary plane Sf, the opening surface Sa intersects with one side edge 11c of the container body 11A at an obtuse angle, and the opening surface Sa intersects with the other side edge 11d of the container body 11A at an acute angle. Here, the imaginary plane Sf is the same plane as the imaginary plane Sf shown in Fig. 21. In this case, the central axis CL is located on the imaginary plane Sf. In addition, the imaginary plane Sf passes through a first end point (upper end) 15b and a second end point (lower end) 15c of the opening 15.

[0116] The angle θ22 at which the opening surface Sa intersects with one side edge 11c of the container body 11A is preferably 100° or more. In this case, by forming the sealing line 21 parallel to the opening surface Sa, it is possible to prevent liquid from remaining inside one first corner portion 22A (see FIG. 21) inside the liquid storage container 10E. Furthermore, the angle θ23 at which the opening surface Sa intersects with the other side edge 11d of the container body 11A is preferably 50° or less. In this case, by forming the sealing line 21 parallel to the opening surface Sa, it is possible to prevent liquid from remaining inside the other first corner portion 23A (see FIG. 21) inside the liquid storage container 10E.

[0117] 24, the upper end of the other side edge 11d of the container body 11A may be partially cut away. In FIG. 24, when the container body 11A is parallel projected onto the imaginary plane Sf, the opening plane Sa intersects with an extension of the other side edge 11d of the container body 11A at an acute angle. In this case, there is no sharp portion on the peripheral edge 15a of the opening 15 of the container body 11A, so that irritation to the fingers when touching the peripheral edge 15a can be reduced.

[0118] As shown in Figure 25(a), the peripheral edge 15a of the opening 15 of the container body 11A may be formed in a substantially S-shape including a straight line when the container body 11A is projected parallel to the imaginary plane Sf. In this case, as shown in Figure 25(b), when the opening 15 of the container body 11A is crushed and sealed so that the inner surfaces of the opening 15 come into contact with each other, the peripheral edge 15a becomes straight when projected parallel to the imaginary plane Sf. In this case, when the opening 15 of the container body 11A is crushed before sealing, the peripheral edge 15a becomes straight. Therefore, the heating unit of the heat-sealing machine can be positioned to align with this straight line, making the sealing position easy to understand.

[0119] As shown in Figure 26(a), the periphery 15a of the opening 15 of the container body 11A is composed of a first periphery 15a1 and a second periphery 15a2, and a step 15d may be formed between the first periphery 15a1 and the second periphery 15a2. The step 15d is formed at the intersection (first end point 15b and second end point 15c) of the major axis of the (approximately ellipse) of the opening 15 when viewed from a direction perpendicular to the opening surface Sa and the approximate ellipse. The first periphery 15a1 and the second periphery 15a2 are located on different planes. In this case, as shown in FIG. 26(b), when the opening 15 is sealed along the second peripheral portion 15a2, the sealing portion 20 is positioned below the first peripheral portion 15a1 (toward the removal portion 30). Therefore, when the liquid storage container 10E is frozen and dropped, the area between the sealing portion 20 and the first peripheral portion 15a1 is easily damaged, while damage to the sealing portion 20 is suppressed, thereby preventing leakage of the contents. Furthermore, before the opening 15 is sealed, the presence of the second peripheral portion 15a2 can be confirmed from outside the opening 15. In contrast, after the opening 15 is sealed, if the sealing portion 20 is securely sealed, the second peripheral portion 15a2 melts due to the heat generated during sealing and blends with the surrounding molten resin, making it invisible from outside the opening 15. In this way, by checking the presence or absence of the second peripheral portion 15a2, it is possible to determine that the sealing portion 20 is securely sealed when the second peripheral portion 15a2 is not present, and that the sealing portion 20 is not sufficiently sealed when the second peripheral portion 15a2 is present.

[0120] As shown in FIG. 27 , a notch 17 may be formed in the peripheral edge 15a of the opening 15 of the container body 11A, penetrating the peripheral edge 15a in the thickness direction. In this case, the presence of the notch 17 can be confirmed by looking from outside the opening 15 before the opening 15 is sealed. In contrast, after the opening 15 is sealed, if the sealing portion 20 is securely sealed, the notch 17 melts due to the heat generated during sealing and blends with the surrounding molten resin, making it invisible from outside the opening 15. In this way, by checking for the presence or absence of the notch 17, it can be determined that the sealing portion 20 is securely sealed if the notch 17 is not present, and that the sealing portion 20 is not sufficiently sealed if the notch 17 is present.

[0121] As shown in Figure 28(a), the peripheral edge 15a of the opening 15 of the container body 11A may include a first flat portion 18a located on the first end point 15b side and a second flat portion 18b located on the second end point 15c side. The first flat portion 18a and the second flat portion 18b may be located on different planes perpendicular to the central axis CL. As shown in Figure 28(b), when the liquid storage container 10E is produced by injection molding, when the molded product is removed from the mold (core pin) 91A by the stripper 92A, the first flat portion 18a and the second flat portion 18b are flat, so that the stripper 92A can easily press the end surface of the opening 15 of the container body 11A, facilitating removal.

[0122] It is preferable that container body 11A is transparent to facilitate visualization of its interior. Furthermore, the cross section of container body 11A perpendicular to the central axis CL is not limited to a circle, but may be a flat shape such as an ellipse. In this case, the surface area of ​​container body 11A per volume increases, and therefore, when liquid storage container 10E is frozen and thawed after sealing, the time required for freezing and thawing can be shortened, thereby reducing damage to the liquid, such as cells.

[0123] In this embodiment, the closing portion is composed of the removal portion 30 described above. The opening surface Sa is positioned non-parallel to the plane that constitutes the removal portion 30 and the stand portion 33. The closing portion is also provided with an engagement portion. This engagement portion engages with a storage recess 72, which is an engaged portion of the mounting base 70 described below, thereby restricting rotation of the container body 11A around the central axis CL. In this case, the engagement portion is composed of the stand portion 33 that is generally diamond-shaped in plan view described above.

[0124] According to this embodiment, by filling the liquid into the liquid storage container 10E in a tilted state before sealing, it is possible to prevent air bubbles from being generated in the liquid when filling (see FIG. 9). This makes it possible to prevent air bubbles from adversely affecting cells, for example, when a cell suspension is used as the liquid.

[0125] Furthermore, by tilting the opening surface Sa with respect to the central axis CL of the container body 11A, for example, as shown in FIGS. 29(a) and 29(b), when filling the liquid storage container 10E with a cell suspension using a pipette 46 tilted with respect to the horizontal plane Sh while aligning the central axis CL of the container body 11A parallel to the vertical direction, the cell suspension is filled along the side of the liquid storage container 10E, thereby suppressing the generation of bubbles and minimizing the impact of damage to the cells. Furthermore, it is necessary to fill the liquid so that the liquid does not adhere to the to-be-sealed portion 20A corresponding to the sealing portion 20. In this case, the pipette 46 is maintained at a certain angle (e.g., α3°) with respect to the horizontal plane Sh. This allows for a wider range in which the tip of the pipette 46 can be positioned compared to when the opening surface Sa is perpendicular to the central axis CL of the container body 11A, making the filling operation easier.

[0126] Furthermore, according to this embodiment, cells can be accumulated using a typical cell centrifugation procedure (example conditions: rotation speed: 1000 rpm, time: 3 min, temperature: 20°C). That is, when the centrifugation procedure is performed, cells C can be accumulated at the other first corner portion 23A, which has an acute angle (see FIG. 30). For example, the liquid storage container 10E may be set in a jig that matches its shape, and the cells C may be accumulated at the other first corner portion 23A using a centrifuge. Alternatively, the liquid storage container 10E may be placed in a centrifuge tube, and a jig may be prepared in which the liquid storage container 10E is fixed with a buffer material or the like to prevent it from moving within the centrifuge tube. This may then be set in a typical jig for centrifuge tubes, and the cells C may be accumulated at the other first corner portion 23A using a centrifuge.

[0127] Furthermore, according to this embodiment, as shown in FIG. 31(a), the portion (handle portion) Pa for gripping the liquid container 10E during aspirating liquid can be made wider than when the opening surface Sa is perpendicular to the central axis CL of the container body 11A. This makes the liquid container 10E easier to hold and improves handling. That is, not only the sealed portion 20 but also the area located closer to the first corner portion 23A than the first corner portion 22A can be used as the handle portion Pa. Furthermore, as shown in FIG. 31(b), even if the injection needle 45 were to penetrate the liquid container 10E, the tip of the injection needle 45, which could potentially puncture the operator's hand, would be farther away from the operator's hand than the handle portion Pa, making the aspirating operation safer. In contrast, when the opening surface Sa is perpendicular to the central axis CL of the container body 11A, the tip of the injection needle 45 would not be farther away from the operator's hand, increasing the risk.

[0128] [Combination of liquid container and mounting base] Next, the configuration of the combination of the liquid container and the mounting table will be described with reference to FIGS.

[0129] 32 to 34, an assembly 80 according to the present embodiment includes a liquid storage container 10E before sealing, and a mounting base 70 on which the liquid storage container 10E is placed. The configuration of the liquid storage container 10E is the same as the configuration shown in Figures 22 and 23, and therefore a detailed description thereof will be omitted here.

[0130] The mounting base 70 has a base main body 71 and an engaged portion formed on the base main body 71. The base main body 71 has a generally rectangular parallelepiped shape and a flat bottom surface 77. The base main body 71 preferably has a weight sufficient to stably hold the liquid storage container 10E when the liquid storage container 10E is placed on the mounting base 70. The mounting base 70 is placed on an installation surface Sg. At this time, the bottom surface 77 of the mounting base 70 comes into contact with the installation surface Sg, thereby stably holding the mounting base 70. The bottom surface 77 is a surface that defines the installation surface Sg and is the surface that comes into contact with the installation surface Sg when the mounting base 70 is placed in a normal state. Furthermore, for example, if the mounting base 70 has three or more scaffolds, the bottom surface 77 includes a surface formed by the three or more scaffolds.

[0131] In this case, the engaged portion is a concave storage recess 72 formed on the surface of the base main body 71. As shown in FIG. 32 , the storage recess 72 has a first surface 73, a second surface 74, and a third surface 75. Of these, the first surface 73 is abutted by the bottom side of the stand 33 (the side opposite the connecting portion 32) when the liquid storage container 10E is placed on the placing base 70. The second surface 74 supports the container body 11A of the liquid storage container 10E from below when the liquid storage container 10E is placed on the placing base 70. The third surface 75 engages the periphery of the stand 33 from above when the liquid storage container 10E is placed on the placing base 70, thereby preventing the liquid storage container 10E from tipping over.

[0132] The mounting table 70 can be made from materials such as metal, resin, etc. When the mounting table 70 is made from resin, examples of the resin include polyethylene (PE), polypropylene (PP), polyethylene terephthalate (PET), etc. Furthermore, the mounting table 70 is preferably transparent so that the inside of the liquid storage container 10E can be easily viewed from all directions.

[0133] As shown in FIGS. 33 and 34 , when the liquid storage container 10E is placed on the mounting base 70 and the stand portion 33 (engaging portion) of the liquid storage container 10E is engaged with the storage recess 72 (engaged portion) of the mounting base 70, the liquid storage container 10E is placed on the mounting base 70 with the central axis CL of the container body 11A tilted relative to the bottom surface 77 of the mounting base 70. At this time, the opening 15 of the liquid storage container 10E faces away from the mounting base 70. At this time, the opening surface Sa opens in the direction opposite to the direction in which the liquid storage container 10E tilts relative to the bottom surface 77 of the mounting base 70. That is, in FIG. 34 , the opening surface Sa opens in the direction (the direction of the arrow D2 in FIG. 34 ) opposite to the direction in which the liquid storage container 10E tilts relative to the bottom surface 77 (the direction of the arrow D1 in FIG. 34 ). This allows the opening area of ​​the opening 15 of the liquid storage container 10E to be set wide. Furthermore, the liquid storage container 10E is stably held by the mounting base 70, and rotation of the liquid storage container 10E around the central axis CL is restricted. Furthermore, when placed on the mounting base 70, the liquid storage container 10E is preferably movable only in the insertion direction (the direction of the central axis CL) when inserting the liquid storage container 10E into the storage recess 72, and is preferably substantially unable to move in other directions, particularly in directions perpendicular to the insertion direction.

[0134] Here, "opening 15 faces the opposite side of mounting base 70" means that when liquid storage container 10E is placed on mounting base 70, opening 15 opens on the opposite side of mounting base 70, making it possible to inject liquid into liquid storage container 10E from vertically above through opening 15.

[0135] As shown in FIG. 34, when the liquid storage container 10E is placed on the mounting base 70, it is preferable that the opening surface Sa and the bottom surface 77 of the mounting base 70 are parallel. In this case, the area of ​​the opening 15 when viewed from above (the positive side in the Z direction) is maximized, making it easier to fill the liquid storage container 10E with liquid. Furthermore, when the volume of liquid to be filled into the liquid storage container 10E is constant, the distance between the liquid level and the sealing part 20 can be maximized. That is, when the liquid storage container 10E is tilted (FIG. 35(b)), the minimum distance Y2 between the liquid level and the sealing part 20 is greater than the minimum distance Y1 between the liquid level and the sealing part 20 when the liquid storage container 10E is not tilted (FIG. 35(a)) (Y2>Y1). That is, Y2=Y1×sinα, and 0 <sinα<1であるため、Y2> Therefore, when a liquid that is affected by heat, such as a cell suspension, is used, damage to the liquid due to heat conduction during heat sealing can be further reduced.

[0136] However, the opening surface Sa and the bottom surface 77 (installation surface Sg) may be disposed non-parallel. In this case, as shown in Figures 36(a) and 36(b), the angle θ24 formed between the opening surface Sa and a surface parallel to the bottom surface 77 (installation surface Sg) is preferably between -29° and 13°. By setting the angle θ24 within this range, when sealing the opening 15 using a general heat sealing machine (with a width of the portion to be sealed of 5 mm, 10 mm, or 20 mm), it is possible to seal the thin-walled portion of the container body 11A that is easy to seal while ensuring a certain seal width Ws (for example, about 2 mm) or more, thereby improving the airtightness of the liquid storage container 10E.

[0137] Furthermore, it is more preferable that the angle θ24 be between −10° and 13°. By setting the angle θ24 in this range, in addition to the aforementioned effect of increasing the airtightness of the liquid storage container 10E, when heat-sealing is performed parallel to the installation surface Sg, the angle θ21 (see FIG. 21) of the first corner portion 23A after sealing can be made small (for example, 50° or less), thereby preventing liquid from remaining inside the other first corner portion 23A.

[0138] Note that when the angle θ24 is a negative (-) angle, it means that when the liquid storage container 10E is placed on the mounting base 70, the first end point 15b of the opening 15 is positioned higher than the second end point 15c (see FIG. 36(a)). Also, when the angle θ24 is a positive (+) angle, it means that when the liquid storage container 10E is placed on the mounting base 70, the second end point 15c of the opening 15 is positioned higher than the first end point 15b (see FIG. 36(b)).

[0139] FIG. 37 shows the opening 15 viewed from above (perpendicular to the installation surface Sg) with the liquid storage container 10E placed on the mounting base 70. In FIG. 37, a first line L11 is a line connecting the first end point 15b and the second end point 15c of the opening 15, and a second line L12 is a line passing through the central axis CL and perpendicular to the first line L11. In this case, the length of the first line L11 is preferably longer than the length of the second line L12. This makes it easier to crush the opening 15 when heat-sealing the liquid storage container 10E, making it easier to seal the liquid storage container 10E. Not only is it easier to seal the liquid storage container 10E, but the opening 15 can be reliably sealed by heat welding or the like each time, and the sealed state can be stably maintained even when subjected to vibrations during transportation, etc.

[0140] Furthermore, the thickness of the wall surface forming the opening 15 is preferably thinner than the thickness of the barrel 12 of the container body 11A. Alternatively, as shown in FIG. 38(a), the wall thickness of the container body 11A may be gradually reduced from a gradual change start position Ps located midway along the barrel 12 toward the opening 15. The portion to be sealed 20A corresponding to the sealing portion 20 changes between the state before the opening 15 is crushed (FIG. 38(a)) and the state after the opening 15 is crushed to seal it (FIG. 38(b)). That is, if the upper edge 20A1 and the lower edge 20A2 of the portion to be sealed 20A are to be substantially parallel in the crushed state (FIG. 38(b)), the distance between the upper edge 20A1 and the lower edge 20A2 needs to be wider on the side of the second end point 15c than on the side of the first end point 15b in the state before the opening 15 is crushed (FIG. 38(a)). Therefore, it is preferable that the gradual change start position Ps is closer to the take-out portion 30 on the second end point 15c side than on the first end point 15b side.

[0141] [Operation of this embodiment] Next, the operation of this embodiment having the above-described configuration will be described.

[0142] First, an unsealed liquid storage container 10E is prepared. Next, this liquid storage container 10E is placed on the mounting base 70. During this process, the liquid storage container 10E is moved parallel to the central axis CL, and the stand portion 33, which is an engaging portion of the liquid storage container 10E, is engaged with the storage recess 72, which is an engaged portion of the mounting base 70 (see FIG. 33). This forms a combination 80 of the liquid storage container 10E and the mounting base 70. At this time, the stand portion 33 of the liquid storage container 10E abuts against the first surface 73 of the storage recess 72, and an area of ​​the container body 11A near the removal portion 30 abuts against the second surface 74 of the storage recess 72. Furthermore, the stand portion 33 of the liquid storage container 10E is engaged with the third surface 75 of the storage recess 72, preventing the liquid storage container 10E from tipping over.

[0143] In this embodiment, a method for manufacturing an assembly is also provided, which includes the steps of preparing the liquid storage container 10E, preparing the mounting table 70, and mounting the liquid storage container 10E on the mounting table 70.

[0144] As a result, the liquid storage container 10E is prevented from rotating around the central axis CL by the storage recess 72 of the mounting base 70. Furthermore, when the liquid storage container 10E is placed on the mounting base 70, the opening surface Sa opens in the direction opposite to the direction in which the liquid storage container 10E is inclined relative to the bottom surface 77 of the mounting base 70. Therefore, the opening 15 of the liquid storage container 10E faces upward. This allows the liquid storage container 10E to be stably held with its opening 15 facing upward.

[0145] Next, a predetermined amount of liquid is filled into the container body 11A through the opening 15 of the liquid storage container 10E. In this case, the liquid storage container 10E does not rotate, and the orientation of the liquid storage container 10E is fixed with the opening 15 facing upward. This allows the liquid storage container 10E to be stably filled with liquid from above. Furthermore, since the liquid can be filled with liquid while the central axis CL of the liquid storage container 10E is tilted, the generation of air bubbles in the liquid during filling can be suppressed. This can prevent air bubbles from adversely affecting cells, for example, when a cell suspension is used as the liquid. Furthermore, when the central axis CL of the liquid storage container 10E is tilted and the cell suspension is filled into the liquid storage container 10E using a filling nozzle or pipette parallel to the vertical direction, the cell suspension can be filled along the side of the liquid storage container 10E to suppress the generation of air bubbles, thereby minimizing the impact of damage to the cells. Furthermore, the liquid needs to be filled so that it does not adhere to the to-be-sealed portion 20A corresponding to the sealing portion 20. According to this embodiment, the area of ​​opening 15 facing vertically upward is large, so that filling nozzles and pipettes can be arranged over a wide area.

[0146] Next, while the liquid storage container 10E is placed on the mounting table 70, the periphery of the open opening 15 of the liquid storage container 10E is heat-sealed to form the sealed portion 20. At this time, the periphery of the opening 15 of the liquid storage container 10E may be clamped and heat-sealed by a heating portion extending parallel to the imaginary line VL. In this case, the liquid storage container 10E does not rotate, and the orientation of the liquid storage container 10E is fixed with the opening 15 facing upward, so the liquid storage container 10E can be stably heat-sealed. In this way, a sealed liquid storage container 10E (a container filled with liquid) is obtained.

[0147] [Variations] Next, various modifications of this embodiment will be described with reference to Figures 39 to 65. Figures 39 to 65 are views showing liquid storage containers according to various modifications of this embodiment. In Figures 39 to 65, the same parts as those shown in Figures 21 to 38 are given the same reference numerals and detailed descriptions thereof will be omitted.

[0148] (First Modification) 39(a)-(c) show an assembly 80A according to a first modified example of the present embodiment. In Figures 39(a)-(c), the assembly 80A includes a liquid storage container 10F before sealing and a mounting base 70A on which the liquid storage container 10F is placed.

[0149] Of these, the liquid storage container 10F has a cylindrical container body 11A having a sealable opening 15 at one end and a closing portion 30A at the other end. In this case, the closing portion 30A is provided with engagement portions 33A, and the engagement portions 33A each include a protrusion that protrudes outward from the container body 11A.

[0150] 39(a), the engaging portion 33A protrudes in a direction perpendicular to the central axis CL of the container body 11A. In this case, the engaged portion of the mounting table 70A may have substantially the same configuration as the accommodating recess 72 shown in FIGS. 22 and 23 described above.

[0151] 39(b), the engaging portion 33A protrudes in a direction parallel to the central axis CL of the container body 11A. In this case, the engaged portion of the mounting table 70A has an elongated accommodating recess 72A having a shape corresponding to the engaging portion 33A.

[0152] 39(c), the engaging portion 33A protrudes in a direction parallel to the central axis CL of the container body 11A. The engaging portion 33A is connected to the closing portion 30A via a connecting portion 32A. In this case, the engaged portion of the mounting base 70A has an inner protruding portion 35 that holds the engaging portion 33A between the closing portion 30A and the engaging portion 33A.

[0153] (Second Modification) 40(a) and (b) show an assembly 80B according to a second modification of the present embodiment. In Figures 40(a) and (b), the assembly 80B includes a liquid storage container 10G before sealing and a mounting base 70B on which the liquid storage container 10G is placed.

[0154] Of these, the liquid storage container 10G has a cylindrical container body 11A having a sealable opening 15 at one end and a closing portion 30B at the other end. In this case, the closing portion 30B is provided with engagement portions 33B, and the engagement portions 33B each include a recess recessed inward from the container body 11A.

[0155] 40(a), the engaging portion 33B includes a recess that is recessed in a direction parallel to the central axis CL of the container body 11A. In this case, the engaged portion of the mounting table 70B has an accommodating protrusion 76B that has a shape corresponding to the engaging portion 33B.

[0156] 40(b), the engaging portion 33B includes a recess that is recessed in a direction parallel to the central axis CL of the container body 11A. The engaging portion 33B is connected to the closing portion 30B via a connecting portion 32B. In this case, the engaged portion of the mounting base 70B has a storage protrusion 76B that has a shape corresponding to the engaging portion 33B.

[0157] (Third Modification) 41(a) and (b) show an assembly 80C according to a third modified example of the present embodiment. In Figures 41(a) and (b), the assembly 80C includes a liquid storage container 10H before sealing and a mounting base 70C on which the liquid storage container 10H is placed.

[0158] Of these, liquid storage container 10H has a cylindrical container body 11A having a sealable opening 15 at one end and a closing portion 30C at the other end. In this case, engagement portions 33C are provided on the side surfaces of container body 11A, and each engagement portion 33C protrudes outward from the side surface of container body 11A.

[0159] 41(a), the engaging portion 33C protrudes in a direction perpendicular to the central axis CL of the container body 11A. In this case, the engaged portion of the mounting table 70C has an accommodating recess 72C having a shape corresponding to the engaging portion 33C.

[0160] 41(b), the engaging portion 33C protrudes in a direction inclined with respect to the central axis CL of the container body 11A. In this case, the engaged portion of the mounting table 70C has an accommodating recess 72C having a shape corresponding to the engaging portion 33C, and this accommodating recess 72C extends parallel to the vertical direction.

[0161] (Fourth Modification) 42(a) and (b) show an assembly 80D according to a fourth modification of the present embodiment. In Figures 42(a) and (b), the assembly 80D includes a liquid storage container 10I before sealing and a mounting base 70D on which the liquid storage container 10I is placed.

[0162] Of these, liquid storage container 10I has a cylindrical container body 11A having a sealable opening 15 at one end and a closing portion 30D at the other end. In this case, engagement portions 33D are provided on the side surfaces of container body 11A, and each engagement portion 33D is recessed inward from the side surface of container body 11A.

[0163] 42(a), the engaging portion 33D includes a recess that is recessed in a direction perpendicular to the central axis CL of the container body 11A. In this case, the engaged portion of the mounting table 70D has an accommodating protrusion 76D that has a shape corresponding to the engaging portion 33D.

[0164] 42(b), the engaging portion 33D includes a recess that is recessed in a direction inclined with respect to the central axis CL of the container body 11A. In this case, the engaged portion of the mounting base 70D has a accommodating protrusion 76D that has a shape corresponding to the engaging portion 33D, and this accommodating protrusion 76D extends parallel to the vertical direction.

[0165] (Fifth Modification) 43(a)-(d) show an assembly 80E according to a fifth modified example of the present embodiment. In Fig. 43(a)-(d), the assembly 80E includes a liquid storage container 10J before sealing and a mounting base 70 on which the liquid storage container 10J is placed.

[0166] 43(a), a mark 36 indicating the liquid filling position is disposed on the container body 11A of the liquid storage container 10J. The mark 36 is formed so as to protrude from the inner surface of the container body 11A.

[0167] 43(b), a mark 36 indicating the liquid filling position is disposed on the container body 11A of the liquid storage container 10J. The mark 36 is formed so as to protrude from the outer surface of the container body 11A. In this case, it is preferable that the container body 11A is transparent.

[0168] 43(c), a mark 36 indicating the location to be filled with liquid is disposed in the storage recess 72 of the mounting table 70. The mark 36 is formed so as to protrude outward within the storage recess 72. In this case, it is preferable that the container body 11A is transparent.

[0169] 43(d), a mark 36 indicating the location to be filled with liquid is placed in the storage recess 72 of the mounting table 70. The mark 36 is formed so as to be recessed inward within the storage recess 72. In this case, it is preferable that the container body 11A is transparent.

[0170] Such a mark 36 is used as an indicator when filling the liquid storage container 10J with liquid from above. By filling the liquid using this mark 36 as an indicator, the liquid does not adhere to the portion to be sealed 20A that corresponds to the sealing portion 20, and it is possible to prevent the liquid from remaining in the sealing portion 20 after sealing. The mark 36 may be a convex or concave portion formed on the container body 11A or the mounting base 70, or may be a pattern formed by printing.

[0171] 44(a)-(c), the mark 36 is preferably provided in an area (the shaded area in FIGS. 44(a)-(c)) where the opening 15 of the liquid storage container 10J placed on the mounting base 70 is projected parallel to the installation surface Sg, excluding the portion to be sealed 20A. This makes it easier to fill the liquid storage container 10J with liquid and further prevents the liquid from adhering to the portion to be sealed 20A.

[0172] (Sixth Modification) Fig. 45 shows an assembly 80F according to a sixth modified example of the present embodiment. In Fig. 45, the assembly 80F includes a plurality of unsealed liquid storage containers 10E and a mounting base 70E on which the plurality of liquid storage containers 10E are placed.

[0173] The mounting base 70E has a plurality of holding recesses 72 formed therein, each of which is an engaging portion capable of holding a liquid storage container 10E. In this case, the plurality of liquid storage containers 10E are preferably lined up in a row along a straight line connecting the first end points 15b of the openings 15 of the respective liquid storage containers 10E. By lining up the plurality of liquid storage containers 10E in a row in this manner, the plurality of liquid storage containers 10E can be efficiently heat-sealed at once using the heating unit 63 (imaginary line) of the heat-sealing machine. Furthermore, for example, when the liquid storage containers 10E are delivered to a filling worker in the form of an assembly 80F, the worker does not need to line up the liquid storage containers 10E for filling with liquid, and can proceed directly to the filling work, thereby improving the efficiency of the filling work.

[0174] Furthermore, it is preferable that the opening 15 of the liquid storage container 10E be positioned above the mounting base 70E during filling. This allows the tip of a filling nozzle or pipette used to fill the liquid to be moved smoothly to the opening 15, making filling the liquid easier. Furthermore, when removing the filled liquid storage container 10E from the mounting base 70E, it is easy to grasp the parts other than the opening 15 with your hands, making it easy to remove the liquid storage container 10E. Furthermore, since the work can be performed without touching the opening 15 with your hands, the risk of contaminating the filled liquid can be reduced. Furthermore, the assembled product 80F after filling can be directly placed in a sealing machine, and multiple liquid storage containers 10E can be sealed at once, as shown in FIG. 45. This allows the work from filling the liquid to sealing the opening 15 to be performed continuously and collectively, improving work efficiency.

[0175] 46(a), the mounting table 70E may be configured with a mounting table main body 82 and a mounting table cover 83 that can be attached to the mounting table main body 82. In this case, first, multiple liquid storage containers 10E are set in the storage recesses 72 of the mounting table main body 82. Then, as shown in FIG. 46(b), the mounting table cover 83 is attached to the mounting table main body 82. This allows the mounting table cover 83 to lock each liquid storage container 10E, preventing the liquid storage containers 10E from falling over. In this case, it is easier to set the liquid storage containers 10E on the mounting table main body 82.

[0176] 47, when the mounting table main body 82 and the mounting table cover 83 are manufactured by vacuum forming or the like, the mounting table 70E may have a tray-shaped mounting table main body 82 and a mounting table cover 83 with a hole formed therein. In this case, the mounting table cover 83 may be set after the liquid storage container 10E is set on the mounting table main body 82, or alternatively, the mounting table cover 83 may be set on the mounting table main body 82 before the liquid storage container 10E is set.

[0177] 48, the mounting table main body 82 and the mounting table cover 83 may be manufactured by vacuum forming or the like, with a first engaging protrusion 84a provided on the mounting table main body 82 and this first engaging protrusion 84a engaging with a first engaging recess 84b provided on the mounting table cover 83. This makes it difficult for the mounting table cover 83 to come off the mounting table main body 82. Alternatively, the mounting table main body 82 may be provided with a first engaging recess 84b, and the mounting table cover 83 may be provided with the first engaging protrusion 84a. Alternatively, the upper surface of the mounting table main body 82 may be provided with a second engaging recess 85a, and this second engaging recess 85a may be engaged with a second engaging protrusion 85b provided on the mounting table cover 83. This makes it even more difficult for the mounting table cover 83 to come off the mounting table main body 82. Alternatively, the upper surface of the mounting table main body 82 may be provided with a second engaging recess 85b, and this second engaging recess 85a may be provided with a second engaging recess 85b provided on the mounting table cover 83. Also, only one of the combination of the first engaging protrusion 84a and the first engaging recess 84b and the combination of the second engaging recess 85a and the second engaging protrusion 85b may be provided.

[0178] Furthermore, as shown in FIG. 49, a protective cover 86 may be provided to cover the mounting platform main body 82 and the mounting platform cover 83. The mounting platform main body 82, the mounting platform cover 83, and the protective cover 86 are each manufactured by vacuum forming or the like. In this case, a third engaging protrusion 87a may be provided on the side of the mounting platform main body 82, and this third engaging protrusion 87a may engage with a third engaging recess 87b provided on the protective cover 86. By attaching the protective cover 86 before filling the liquid storage container 10E with liquid, it is possible to prevent foreign matter from entering the liquid storage container 10E. In addition, it is preferable that the engagement strength (difficulty of removal) between the first engaging protrusion 84a and the first engaging recess 84b is greater than the engagement strength (difficulty of removal) between the third engaging protrusion 87a and the third engaging recess 87b. This prevents the perforated mounting platform cover 83 from coming off due to vibrations or the like when removing the protective cover 86, thereby improving operability. Furthermore, when the combined product 80F is delivered to the filling worker, the protective cover 86 makes it difficult for foreign matter to get into the liquid storage container 10E until filling of the liquid begins, and the filling work can be started by simply removing the protective cover 86, which is preferable from a hygienic standpoint.

[0179] 50, the mounting table 70E may be configured from a mounting table main body 82 without providing a mounting table cover 83. In this case, the mounting table main body 82 may be manufactured by vacuum forming or the like, and an engaging portion 88 that engages with a part of the liquid storage container 10E (for example, the stand portion 33) may be provided in the storage recess 72 of the mounting table main body 82. This eliminates the need for the mounting table cover 83, reduces the preparation process, and reduces costs by reducing the number of materials used.

[0180] (Seventh Modification) Figures 51 and 52 show an assembly 80G according to a seventh modification of the present embodiment. In Figures 51 and 52, the assembly 80G includes a plurality of unsealed liquid storage containers 10E and a mounting base 70F on which the plurality of liquid storage containers 10E are placed.

[0181] The mounting table 70F has a mounting table main body 82 and a protective cover 86 that is detachable from the mounting table main body 82. The mounting table main body 82 and the protective cover 86 may be made of synthetic resin. Alternatively, the mounting table main body 82 and the protective cover 86 may each be manufactured by a sheet molding method.

[0182] The mounting base main body 82 is formed with a plurality of (three in the example shown in Figures 51 and 52) accommodating recesses 72, which are engaged portions capable of accommodating one liquid storage container 10E each. The protective cover 86 is also provided with a plurality of pressing portions 91. Each pressing portion 91 presses the body portion 12 of the liquid storage container 10E from above, and serves to prevent the liquid storage container 10E from moving within the accommodating recess 72. The pressing portions 91 are provided at positions that correspond to the accommodating recesses 72 when the protective cover 86 is attached to the mounting base main body 82. It is preferable that the number of pressing portions 91 is the same as the number of accommodating recesses 72.

[0183] In this case, first, the multiple liquid storage containers 10E are set in the storage recesses 72 of the mounting base main body 82, respectively. Then, the protective cover 86 is attached to the mounting base main body 82. This allows the pressing portions 91 of the protective cover 86 to fix each liquid storage container 10E, preventing the liquid storage containers 10E from coming off the storage recesses 72. This prevents the liquid storage containers 10E from falling off the mounting base main body 82.

[0184] Furthermore, a third engaging protrusion 87a may be provided on the mounting base main body 82, and this third engaging protrusion 87a may engage with a third engaging recess 87b provided on the protective cover 86. A plurality of third engaging protrusions 87a and third engaging recesses 87b (ten in the example shown in Figures 51 and 52) may be provided. This makes it difficult for the protective cover 86 to come off from the mounting base main body 82. Furthermore, when the assembled product 80G is delivered to a filling worker, the protective cover 86 makes it difficult for foreign matter to get into the liquid storage container 10E until filling with liquid begins, and at the time of filling, the filling work can begin simply by removing the protective cover 86, which is preferable from a hygienic standpoint.

[0185] Next, the mounting base main body 82 will be further described. The mounting base main body 82 has a main body top surface 82a and a first main body side surface 82b, a second main body side surface 82c, a third main body side surface 82d, and a fourth main body side surface 82e, each extending downward (away from the protective cover 86) from the main body top surface 82a. Of these, a storage recess 72 is formed in the main body top surface 82a. The first main body side surface 82b and the second main body side surface 82c each extend along the longitudinal direction of the liquid storage container 10E. The third main body side surface 82d and the fourth main body side surface 82e each extend along the lateral direction (width direction) of the liquid storage container 10E. The third main body side surface 82d is located on the opening 15 side of each liquid storage container 10E, and the fourth main body side surface 82e is located on the stand portion 33 side of each liquid storage container 10E.

[0186] A plurality of pillow portions 92 (three in the example shown in FIGS. 51 and 52 ) are provided on the main body top surface 82a of the mounting base main body 82. The pillow portions 92 each protrude upward (toward the protective cover 86) from the main body top surface 82a. The pillow portions 92 support the body portion 12 of the liquid storage container 10E from below, and serve to prevent the liquid storage container 10E from tipping toward the third main body side surface 82d. The pillow portions 92 also have a contact surface 92a that comes into contact with and supports the body portion 12. The contact surface 92a may have a shape corresponding to the shape of the body portion 12. For example, if the body portion 12 has a cylindrical or conical surface, the contact surface 92a may be configured as a cylindrical or conical surface that curves downward (toward the opposite side of the protective cover 86). The pillow portions 92 are each provided adjacent to the storage recess 72. Specifically, the pillow portion 92 is formed so that its contact surface 92a is continuous with the support surface 78a (described later) of the accommodation recess 72. It is preferable that the number of pillow portions 92 is the same as the number of accommodation recesses 72.

[0187] By providing the pillow portion 92 in this manner, the body portion 12 of the liquid storage container 10E is supported from below, preventing the liquid storage container 10E from tipping toward the third main body side surface 82d when filling it with liquid. That is, when the liquid to be filled is a cellular preparation, the liquid is filled with the tip of the filling nozzle N in contact with the inner surface of the body portion 12 (see FIG. 53). At this time, the body portion 12 of the liquid storage container 10E is held by the pillow portion 92. Therefore, by placing the tip of the filling nozzle N on the pillow portion 92, it is possible to prevent the liquid storage container 10E from tipping toward the third main body side surface 82d due to being pushed by the filling nozzle N. Furthermore, when the body portion 12 of the liquid storage container 10E is transparent, aligning the tip of the filling nozzle N with the pillow portion 92 can prevent the liquid from adhering to the portion to be sealed 20A. The pillow portion 92 may be transparent, but if the pillow portion 92 is opaque, it is easier to align the tip of the filling nozzle N with the pillow portion 92. For this reason, it is preferable that the maximum height H1 (maximum distance from the main body top surface 82a) (see Figure 53) of the pillow portion 92 be set so that the tip of the filling nozzle N can be positioned on the contact surface 92a and the contact surface 92a does not reach the portion to be sealed 20A.

[0188] 54, the contact surface 92a of the pillow portion 92 of the mounting base main body 82 is preferably within the range of an area Ax (the shaded area in FIG. 54) in a plan view (as viewed from the normal direction of the main body top surface 82a). This area Ax is an area that is surrounded by the lower edge 20A2 of the portion to be sealed 20A and the peripheral edge 15a of the opening 15 in a plan view, and is located on the side of the second end point 15c. By having the contact surface 92a within the range of the area Ax, it is possible to easily obtain the effects of preventing liquid from adhering to the portion to be sealed 20A described above and preventing the liquid storage container 10E from tipping toward the third main body side surface 82d.

[0189] As shown in FIG. 55, the accommodating recess 72 has a container holding portion 78 and a rotation prevention portion 79 formed adjacent to the container holding portion 78.

[0190] Of these, the container holding portion 78 holds the body 12 of the liquid storage container 10E. The container holding portion 78 is located on the pillow portion 92 side of the storage recess 72. The container holding portion 78 is recessed downward (opposite the protective cover 86) from the main body top surface 82a. The container holding portion 78 supports the body 12 of the liquid storage container 10E from below and prevents the liquid storage container 10E from coming off the storage recess 72. The container holding portion 78 has a support surface 78a that supports the body 12. The support surface 78a may have a shape corresponding to the shape of the body 12. For example, if the surface of the body 12 that contacts the support surface 78a is a cylindrical or conical surface, the support surface 78a may be configured as a cylindrical or conical surface that curves downward (opposite the protective cover 86). The support surface 78a may be formed so as to be continuous with the contact surface 92a of the pillow portion 92 described above.

[0191] Also, as shown in FIGS. 55 and 56, a clamping portion 78b is provided at a portion of the container holding portion 78 located on the side of the rotation prevention portion 79. The clamping portion 78b is a portion of the container holding portion 78 whose width is narrower than other portions. This clamping portion 78b sandwiches and holds the body portion 12 of the liquid storage container 10E, and serves to prevent the liquid storage container 10E from falling over when the mounting table body 82 is carried. For example, when carrying the entire mounting table body 82 to a sealing machine to seal the opening 15 after filling the liquid storage container 10E with liquid, the liquid storage container 10E does not fall in the direction of the fourth body side surface 82e, so that the carrying and sealing operations after the filling operation can be performed smoothly. On the other hand, when the liquid storage container 10E is pulled up from the mounting table body 82, the body portion 12 of the liquid storage container 10E comes off from the clamping portion 78b, so that the liquid storage container 10E can be easily removed from the storage recess 72. The width Wb of the container holding portion 78 in this clamping portion 78b is narrower than the width Wa of the portion of the container holding portion 78 on the pillow portion 92 side (Wb < Wa). The width Wa and the width Wb are lengths measured in a direction perpendicular to the central axis CL of the container body 11A on the plane where the main body top surface 82a exists, respectively.

[0192] As shown in FIGS. 55 and 56, the rotation prevention portion 79 accommodates the bottom portion of the liquid storage container 10E (in this case, the stand portion 33 which is an engagement portion), and regulates the rotation of the bottom portion (stand portion 33) of the liquid storage container 10E. As shown in FIG. 55, the rotation prevention portion 79 has a recess bottom surface 79a that contacts the stand portion 33. The lower edge 79b (the edge portion far from the main body top surface 82a) of this recess bottom surface 79a has a (non-circular) shape corresponding to the outer edge of the bottom portion (non-circular) of the liquid storage container 10E. Specifically, the recess bottom surface 79a has a substantially pentagonal shape, and its lower edge 79b has a substantially inverted V shape corresponding to the outer edge of the stand portion 33. By regulating the rotation of the bottom portion of the liquid storage container 10E in this way, it is possible to suppress the difficulty of liquid filling due to the opening 15 not facing upward and the difficulty of sealing the opening 15.

[0193] Next, the protective cover 86 will be described with reference to Figures 51 and 52. The protective cover 86 has a cover top surface 86a and first, second, third, and fourth cover side surfaces 86b, 86c, 86d, and 86e, each extending downward (toward the mounting platform main body 82) from the cover top surface 86a. A pressing portion 91 is formed on the cover top surface 86a. The first and second cover side surfaces 86b and 86c extend along the longitudinal direction of the liquid storage container 10E. The third and fourth cover side surfaces 86d and 86e extend along the lateral direction (width direction) of the liquid storage container 10E. The third cover side surface 86d is located on the opening 15 side of each liquid storage container 10E, and the fourth cover side surface 86e is located on the stand 33 side of each liquid storage container 10E. At least one corner of the first cover side surface 86b to the fourth cover side surface 86e may be provided with, for example, a tab-shaped opening assisting portion 86f (see imaginary lines in FIG. 51) to make it easier to remove the protective cover 86.

[0194] A plurality of (three in the example shown in FIGS. 51 and 52 ) pressing portions 91 are provided on the cover top surface 86a of the protective cover 86. Each pressing portion 91 protrudes downward (toward the mounting base main body 82) from the cover top surface 86a. Each pressing portion 91 presses the body portion 12 of the liquid storage container 10E from above, thereby preventing the liquid storage container 10E from coming off the mounting base main body 82. Each pressing portion 91 has a pressing surface 91a that presses the body portion 12. The pressing surface 91a may have a shape corresponding to the body portion 12. For example, if the body portion 12 includes a cylindrical or conical surface, the pressing surface 91a may be configured as a cylindrical or conical surface that curves upward (toward the cover top surface 86a). It is preferable that the number of pressing portions 91 is the same as the number of storage recesses 72.

[0195] Furthermore, it is preferable that the pressing portion 91 is located closer to the bottom (toward the fourth main body side surface 82e) than the peripheral edge 15a of the opening 15 of the liquid storage container 10E. In this case, as shown in Fig. 52, the peripheral edge 15a of the opening 15 does not come into contact with the protective cover 86 over the entire periphery. In other words, a space Sp is formed between the peripheral edge 15a of the opening 15 and the cover top surface 86a of the protective cover 86.

[0196] By providing the pressing portion 91 on the protective cover 86 in this manner, the body 12 of the liquid storage container 10E accommodated in the storage recess 72 can be pressed from above, and the liquid storage container 10E can be fixed in place without the peripheral edge 15a of the opening 15 coming into contact with the pressing portion 91. This prevents the liquid storage container 10E from moving significantly inside the mounting base main body 82 and the protective cover 86 during transportation of the combined product 80G, thereby preventing damage or scratches to the liquid storage container 10E. Furthermore, the presence of the above-mentioned space Sp can prevent minute foreign matter from being generated by contact between the opening 15 of the liquid storage container 10E and the protective cover 86, and prevents the minute foreign matter from entering the liquid storage container 10E.

[0197] As shown in FIG. 57, multiple combined bodies 80G may be stacked on top of one another. In this case, to reduce the overall height, it is preferable that the upper storage recess 72 of the mounting base main body 82 be at least partially accommodated within the lower retaining portion 91 of the protective cover 86. For example, the top opening 91b of the cover top surface 86a corresponding to the retaining portion 91 may be larger than the rotation prevention portion 79 of the mounting base main body 82 so that the rotation prevention portion 79 can fit into the top opening 91b. Also, as shown in FIG. 57, the retaining portion 91 of the protective cover 86 may be provided with an abutment surface 91c that is inclined from the cover top surface 86a. When multiple combined bodies 80G are stacked on top of one another, the abutment surface 91c of the protective cover 86 abuts against the recess bottom surface 79a of the mounting base main body 82 located above. This abutment surface 91c may be parallel to the recess bottom surface 79a.

[0198] In this way, by keeping the overall height of the multiple stacked combinations 80G low, it is possible to carry many combinations 80G at one time. In addition, when the liquid to be filled is a cell preparation, when the cell preparation is filled in the safety cabinet, many combinations 80G can be placed in the safety cabinet at one time, thereby improving work efficiency.

[0199] Although the present modified example has been described using the liquid storage container 10E shown in FIG. 26 as an example, any other liquid storage container 10E may be used.

[0200] (Eighth Modification) Figures 58 and 59 show a liquid storage container 10K according to an eighth modified example of this embodiment. As shown in Figures 58 and 59, the liquid storage container 10K includes a cylindrical container body 11A having a sealable opening 15 at one end and a removal portion 30 at the other end. A groove 37 and a protrusion 33E serving as an engagement portion are provided on the side surface of the barrel portion 12 of the container body 11A. The groove 37 is recessed inward from the side surface of the container body 11A. The groove 37 is C-shaped in cross section (see Figure 61), and is provided around the entire periphery except for the protrusion 33E.

[0201] Figures 60 and 61 show an assembly 80H according to the eighth modified example. As shown in Figures 60 and 61, the assembly 80H includes a liquid storage container 10K before sealing, and a mounting base 70G on which the liquid storage container 10K is placed.

[0202] A locking portion 93 is formed in the storage recess 72 of the mounting base 70G. The locking portion 93 is an engaged portion that engages with the protrusion 33E, which serves as an engaging portion, of the liquid storage container 10K. As shown in FIG. 61 , the locking portion 93 is generally U-shaped and has a pair of locking protrusions 93a and a locking recess 93b located between the pair of locking protrusions 93a. By having the protrusions 33E of the liquid storage container 10K accommodated in the locking recess 93b, rotation of the liquid storage container 10K can be prevented. This prevents the opening 15 of the liquid storage container 10K from facing upward, which makes it difficult to fill the liquid storage container 10K with liquid or to seal the opening 15.

[0203] Furthermore, the locking protrusion 93a of the locking portion 93 is housed in the groove 37 of the liquid storage container 10K. This prevents the liquid storage container 10K from slipping out in a direction parallel to the central axis CL of the container body 11A (the direction of the arrow in FIG. 60) when the mounting table 70G is carried, allowing for smooth filling and sealing operations.

[0204] (Ninth Variation) Figures 62 and 63 show a liquid storage container 10L according to a ninth modification of this embodiment. As shown in Figures 62 and 63, the liquid storage container 10L includes a cylindrical container body 11A having a sealable opening 15 at one end and a removal portion 30 at the other end. A flat stand portion 33 that supports the container body 11 is connected to the removal portion 30. A groove 37 is provided on the side surface of the barrel portion 12 of the container body 11A. The groove 37 is recessed inward from the side surface of the container body 11A. The groove 37 is provided around the entire circumference of the barrel portion 12, but is not limited to this and may be provided on a portion of the circumference of the barrel portion 12.

[0205] Figure 64 shows an assembly 80I according to a ninth modified example. As shown in Figure 64, the assembly 80I includes a liquid storage container 10L before sealing, and a mounting base 70H on which the liquid storage container 10L is placed.

[0206] A locking portion 94 consisting of a protrusion is formed in the storage recess 72 of the mounting base 70H. The locking portion 94 is an engaged portion that engages with the groove 37 serving as an engaging portion of the liquid storage container 10L. When the liquid storage container 10L is stored in the storage recess 72, the locking portion 94 consisting of the protrusion engages with the groove 37 of the liquid storage container 10L. This prevents the liquid storage container 10L from slipping out in a direction parallel to the central axis CL of the container body 11A (the direction of the arrow in Figure 64) when the mounting base 70H is carried, allowing for smooth filling and sealing operations.

[0207] (Tenth Modification) FIG. 65 shows an assembly 80J according to a tenth modification of the present embodiment. As shown in FIG. 65, the assembly 80J includes a liquid storage container 10E before sealing and a mounting base 70I on which the liquid storage container 10E is placed. In this case, the mounting base 70I has a fixing plate 95 and a pressing protrusion 96 protruding from the fixing plate 95. The plurality of liquid storage containers 10E are removably fixed to the fixing plate 95 by being sandwiched between the two pressing protrusions 96. The height H2 of the fixing plate 95 is preferably set to a height such that the portions to be sealed 20A do not overlap the fixing plate 95 when the liquid storage containers 10E are attached to the fixing plate 95. The plurality of liquid storage containers 10E are contained in a storage box 97 while being fixed to the mounting base 70I. In this case, the central axis CL of the container body 11A is inclined with respect to the box bottom surface 97a of the storage box 97, and the opening 15 of the liquid storage container 10E faces away from the box bottom surface 97a. In this case, a large number (for example, several to several tens) of liquid storage containers 10E can be transported, filled, and sealed all at once, and a large number of liquid storage containers 10E can be placed in a small space.

[0208] It is also possible to combine the multiple components disclosed in the above-described embodiments and modifications as needed, or to delete some of the components disclosed in the above-described embodiments and modifications. [Explanation of symbols]

[0209] 10 Liquid storage container 11 Container body 12 Torso 20 Sealed part 21 Seal line 22, 23 First corner 30 Removal section 31 Thin-walled section 32 Connecting part 33 Stand section 40 Liquid containers

Claims

1. A liquid storage container, a container body that is an injection-molded product made of a resin material capable of containing a liquid; a sealing portion formed on a first side end of the container body, The container body has a cylindrical body portion and a connecting portion formed continuously between the body portion and the sealing portion, a seal line is formed between the connecting portion and the sealed portion, and first corner portions are formed by the seal line and the connecting portion at both ends of the seal line, respectively; When viewed from a normal direction of an imaginary plane that is parallel to a main surface of the sealing portion and includes the seal line, the first corner portion has both a first corner portion that forms an angle of 50° or less and a first corner portion that forms an angle of 100° or more, A liquid storage container that can be arranged independently with the sealing portion facing vertically upward.

2. The liquid container according to claim 1 , wherein a contact angle of the inner surface of the container body with respect to the liquid is 20° or more.

3. 3. A liquid storage container as described in claim 1 or 2, wherein, for a first corner portion that has an angle of 50° or less when viewed from the normal direction of the imaginary plane, when the first corner portion is observed from a direction parallel to the imaginary plane and perpendicular to the sealing line, the angle formed by the container body is 35° or less.

4. The liquid container according to claim 1 , further comprising a take-out portion provided at a second side end of the container body for taking out the liquid contained inside the container body.

5. The liquid container according to claim 4 , further comprising a liquid packaging bag arranged to communicate with the outlet portion.

6. A liquid storage container according to any one of claims 1 to 5; A liquid-containing container comprising: a liquid contained in the liquid container.

7. A step of preparing a liquid-filled container according to claim 6; forming an opening in the container body that communicates with the interior; and removing the liquid in the container body through the opening.

8. 8. The method for producing a predetermined amount of medicinal liquid according to claim 7, wherein the opening is formed by a syringe needle, and the liquid in the container body is extracted from the opening by the syringe needle.

9. A partnership, A liquid storage container according to any one of claims 1 to 5; a mounting base on which the liquid storage container is mounted, The liquid storage container is placed on the stage with the central axis of the container body inclined relative to the bottom surface of the stage and the opening surface of the liquid storage container before sealing inclined relative to the central axis.

10. The combination according to claim 9 , wherein a mark indicating a filling position of the liquid is provided on the liquid storage container or the placement stand.

11. The combination according to claim 9 or 10, wherein a plurality of the liquid storage containers are placed on the placing table.

12. The combination according to any one of claims 9 to 11, wherein the mounting table has a mounting table main body and a protective cover that is detachable from the mounting table main body, and the protective cover is provided with a pressing portion that presses the liquid storage container.

13. A method for producing a combination, comprising: A step of preparing a liquid storage container according to any one of claims 1 to 5; preparing a mounting table; placing the liquid container on the stage; A method for manufacturing an assembly, wherein the liquid storage container is placed on the stage with the central axis of the container body inclined relative to the bottom surface of the stage and the opening surface of the liquid storage container before sealing inclined relative to the central axis.

Images