Blood purification device

Abstract

To provide a blood purification device capable of maintaining a meander part so as to be freely cleaned by priming liquid, and suppressing compression of air in the meander part of a liquid supply pipe path.SOLUTION: When priming a vein side air trap chamber, a control part executes first steps S1a, S1b for compressing until an increase amount of a vein side measurement value exceeds a threshold value, by closing a vein side opening / closing valve, by utilizing a blood pump in a state in which a liquid supply pump, a dialysate pump and a discharge pump are stopped and a vein side air valve is closed, and after the first steps S1a, S1b, executes a second step S2 which opens the vein side air valve while utilizing the blood pump, for adjusting a liquid level height of the priming liquid in the vein side air trap chamber, and after the second step S2, executes a third step S3 for stopping the blood pump while opening the vein side air valve, for reducing a pressure in the vein side air trap chamber and in the meander part.SELECTED DRAWING: Figure 3

Description

[Technical Field]

[0001] The present invention relates to a blood purification device. [Background technology]

[0002] A prior art document disclosing the configuration of a blood purification device is Japanese Patent Laid-Open No. 2012-139405 (Patent Document 1). The blood purification device described in Patent Document 1 includes a blood purifier, an arterial blood circuit, a venous blood circuit, a blood pump, an arterial on-off valve, a priming solution supply line, a drainage line, a venous air trap chamber, a venous on-off valve, an air introduction line, and an air filter. [Prior art documents] [Patent documents]

[0003] [Patent Document 1] Japanese Patent Application Laid-Open No. 2012-139405 Summary of the Invention [Problem to be solved by the invention]

[0004] When an air trap chamber connected to a replacement fluid line is connected to an air supply / exhaust pipe equipped with an air valve via a protective filter, and a serpentine section is provided downstream of the replacement fluid line, if the blood pump is operated with the air valve open to deliver priming solution from the blood purifier to the air trap chamber, air in the air trap chamber may flow from the protective filter toward the serpentine section, which has lower flow resistance, and be compressed within the serpentine section. When the blood pump is stopped with the air valve closed, some of the air compressed within the serpentine section passes through the air trap chamber and flows into the blood purifier. Furthermore, when the venous valve is opened, the pressure of the air compressed within the serpentine section causes the priming solution in the air trap chamber to flow out.

[0005] If a check valve that prevents air from flowing from the air trap chamber toward the serpentine section is provided between the air trap chamber connected to the replacement fluid line and the serpentine section, it is possible to prevent air from the air trap chamber from flowing toward the serpentine section. However, in this case, replacement fluid or dialysate must be used to clean the serpentine section during priming, and the serpentine section cannot be cleaned with the priming fluid, which is less expensive than replacement fluid or dialysate.

[0006] The present invention has been made in consideration of the above problems, and aims to provide a blood purification device that can suppress the inflow of air into the blood purifier and the outflow of priming solution from the air trap chamber to which the fluid replacement line is connected, by suppressing the compression of air within the serpentine section of the fluid replacement line while maintaining the ability to clean the serpentine section with priming solution. [Means for solving the problem]

[0007] A blood purification apparatus according to a first aspect of the present invention comprises a blood purifier, an arterial blood circuit, a venous blood circuit, a replacement fluid line, a dialysate line, a drain line, a blood pump, an arterial air trap chamber, an arterial on-off valve, a venous air trap chamber, a venous on-off valve, a priming solution line, a replacement fluid pump, a dialysate pump, a drain pump, a first measuring bag, a heater, a venous pressure measuring device, a venous protective filter, a venous supply / exhaust line, a venous air valve, and a controller. The arterial blood circuit is connected to the blood purifier and is provided to allow blood to flow into the blood purifier. The venous blood circuit is connected to the blood purifier and is provided to allow blood to flow out of the blood purifier. The replacement fluid line is connected to the venous blood circuit and supplies replacement fluid. The dialysate line supplies dialysate to the blood purifier. The drain line carries drained fluid discharged from the blood purifier. The blood pump is provided in the arterial blood circuit and pumps blood. The arterial air trap chamber is provided in the arterial blood circuit. The arterial on-off valve is provided in the arterial blood circuit and opens and closes the arterial blood circuit. The venous air trap chamber is provided in the venous blood circuit and is connected to a replacement fluid line. The venous on-off valve is provided in the venous blood circuit and opens and closes the venous blood circuit. The priming fluid line is connected to the arterial blood circuit between the arterial on-off valve and the blood pump and supplies priming fluid. The replacement fluid pump is provided in the replacement fluid line and pumps replacement fluid. The dialysate pump is provided in the dialysate line and pumps dialysate. The drainage pump is provided in the drainage line and pumps drained fluid. The first measuring bag is connected to the replacement fluid line and temporarily stores replacement fluid and is capable of pumping the stored replacement fluid. The heater heats replacement fluid located in a meandering portion of the replacement fluid line downstream of the replacement fluid pump. The venous pressure measuring device measures the pressure in the venous air trap chamber. The venous protective filter is provided between the venous air trap chamber and the venous pressure measuring device. The venous supply / exhaust pipe is connected between the venous pressure measuring device and the venous protective filter. The venous air valve is provided in the venous supply / exhaust pipe and opens / closes the venous supply / exhaust pipe. The venous measurement value measured by the venous pressure measuring device is input to the control unit.When priming the venous air trap chamber, the control unit performs a first step of pressurizing the chamber until the increase in the venous measurement value exceeds a threshold by operating the blood pump and closing the venous on-off valve while the infusion pump, dialysate pump, and drainage pump are stopped and the venous air valve is closed; after the first step, the control unit performs a second step of adjusting the liquid level of the priming fluid in the venous air trap chamber by opening the venous air valve while keeping the blood pump running; and after the second step, the control unit performs a third step of depressurizing the venous air trap chamber and the serpentine section by stopping the blood pump while keeping the venous air valve open.

[0008] A blood purification apparatus according to a second aspect of the present invention comprises a blood purifier, an arterial blood circuit, a venous blood circuit, a replacement fluid line, a dialysate line, a drain line, a blood pump, an arterial air trap chamber, an arterial on-off valve, a venous air trap chamber, a venous on-off valve, a priming solution line, a replacement fluid pump, a dialysate pump, a drain pump, a first measuring bag, a heater, an arterial pressure measuring device, an arterial protective filter, an arterial supply / exhaust line, an arterial air valve, and a control unit. The arterial blood circuit is connected to the blood purifier and is provided to allow blood to flow into the blood purifier. The venous blood circuit is connected to the blood purifier and is provided to allow blood to flow out of the blood purifier. The replacement fluid line is connected to the arterial blood circuit and supplies replacement fluid. The dialysate line supplies dialysate to the blood purifier. The drain line carries drained fluid discharged from the blood purifier. The blood pump is provided in the arterial blood circuit and pumps blood. The arterial air trap chamber is provided in the arterial blood circuit and is connected to a replacement fluid line. The arterial on-off valve is provided in the arterial blood circuit and opens and closes the arterial blood circuit. The venous air trap chamber is provided in the venous blood circuit. The venous on-off valve is provided in the venous blood circuit and opens and closes the venous blood circuit. The priming fluid line is connected to the arterial blood circuit between the arterial on-off valve and the blood pump and supplies priming fluid. The replacement fluid pump is provided in the replacement fluid line and pumps replacement fluid. The dialysate pump is provided in the dialysate line and pumps dialysate. The drainage pump is provided in the drainage line and pumps drained fluid. The first measuring bag is connected to the replacement fluid line and can temporarily store replacement fluid and discharge the stored replacement fluid. The heater heats replacement fluid located in a meandering portion of the replacement fluid line downstream of the replacement fluid pump. The arterial pressure measuring device measures the pressure in the arterial air trap chamber. The arterial protection filter is provided between the arterial air trap chamber and the arterial pressure measuring device. The arterial supply / exhaust pipe is connected between the arterial pressure measuring device and the arterial protection filter. The arterial air valve is provided in the arterial supply / exhaust pipe and opens / closes the arterial supply / exhaust pipe. The arterial measurement value measured by the arterial pressure measuring device is input to the control unit.When priming the arterial air trap chamber, the control unit performs a first step of pressurizing the arterial air trap chamber until the increase in the arterial measurement value exceeds a threshold by operating the blood pump and closing the venous on-off valve while the replacement fluid pump, dialysate pump, and drainage pump are stopped and the arterial air valve is closed; after the first step, the control unit performs a second step of adjusting the liquid level of the priming fluid in the arterial air trap chamber by opening the arterial air valve while keeping the blood pump operating; and after the second step, the control unit performs a third step of depressurizing the arterial air trap chamber and the serpentine section by stopping the blood pump while keeping the arterial air valve open.

[0009] In one embodiment of the present invention, the threshold value is 600 Pa or more and 700 Pa or less. [Effects of the Invention]

[0010] According to the present invention, by suppressing the compression of air within the serpentine portion of the fluid replacement line while maintaining the ability to clean the serpentine portion with priming fluid, it is possible to suppress the inflow of air into the blood purifier and the outflow of priming fluid within the air trap chamber to which the fluid replacement line is connected. [Brief explanation of the drawings]

[0011] [Figure 1] 1 is a circuit diagram showing the configuration of a blood purification device according to Embodiment 1 of the present invention. [Figure 2] FIG. 2 is a block diagram showing the electrical connection relationship between the control unit and each component in the blood purification apparatus according to the first embodiment of the present invention. [Figure 3] 4 is a flowchart showing the operation for priming the venous air trap chamber in the blood purification apparatus according to the first embodiment of the present invention. [Figure 4] FIG. 4 is a circuit diagram showing the configuration of a blood purification device according to a second embodiment of the present invention. [Figure 5] 10 is a flowchart showing the operation for priming the arterial air trap chamber in the blood purification apparatus according to the second embodiment of the present invention. DETAILED DESCRIPTION OF THE INVENTION

[0012] Hereinafter, blood purification devices according to various embodiments of the present invention will be described with reference to the drawings. In the following description of the embodiments, the same or corresponding parts in the drawings will be designated by the same reference numerals, and description thereof will not be repeated.

[0013] In the following description of the embodiments, a blood purification device used in continuous renal replacement therapy (CRRT) will be described. However, the blood purification device may also be a blood purification device used in any of continuous hemodiafiltration (CHDF), continuous hemofiltration (CHF), and continuous hemodialysis (CHD).

[0014] (Embodiment 1) Fig. 1 is a circuit diagram showing the configuration of a blood purification apparatus according to Embodiment 1 of the present invention. As shown in Fig. 1, the blood purification apparatus 100 according to Embodiment 1 of the present invention includes a blood purifier 120, an arterial blood circuit 110, a venous blood circuit 116, a replacement fluid line 131, a dialysate line 141, a drainage line 151, a blood pump 111, an arterial air trap chamber 112, an arterial on-off valve 110v, a venous air trap chamber 114, a venous on-off valve 116v, a priming fluid line 191, a replacement fluid pump 161, a dialysate pump 160, a drainage pump 162, a first measuring bag 140, a replacement fluid heater 171, a venous pressure measuring device 115, a venous protective filter 118f, a venous supply / exhaust line 118, a venous air valve 118v, and a controller.

[0015] The blood purification apparatus 100 further includes an arterial pressure measuring device 113, an arterial protective filter 117f, an arterial supply / exhaust pipe 117, an arterial air valve 117v, a first supply source 130, a dialysate heater 170, a scale 180, a priming solution supply source 190, a first connecting pipe 132, a second connecting pipe 152, a second measuring bag 150, a first valve 141v, a second valve 131v, a third valve 151v, a fourth valve 152v, and a fifth valve 191v.

[0016] The blood purifier 120 contains a semipermeable membrane, such as a hollow fiber membrane. The blood purifier 120 has a blood inlet 121 and a blood outlet 122. The arterial blood circuit 110 is connected to the blood inlet 121. The venous blood circuit 116 is connected to the blood outlet 122.

[0017] The arterial blood circuit 110 is provided with a blood pump 111 that pumps blood. In the arterial blood circuit 110, an arterial air trap chamber 112 is provided between the blood pump 111 and the blood purifier 120. The arterial air trap chamber 112 is provided with an arterial pressure measuring device 113 that measures the pressure inside the arterial air trap chamber 112. An arterial protective filter 117f is provided between the arterial air trap chamber 112 and the arterial pressure measuring device 113. The arterial blood circuit 110 is provided with an arterial on-off valve 110v that opens and closes the arterial blood circuit 110.

[0018] Blood collected from a patient's artery flows through the arterial blood circuit 110, has its pressure measured as it passes through the arterial air trap chamber 112, and then flows into the blood purifier 120 from the blood inlet 121. The arterial air trap chamber 112 is provided to prevent air from mixing with the blood in the arterial blood circuit 110.

[0019] The venous blood circuit 116 is provided with a venous air trap chamber 114. The venous air trap chamber 114 is provided with a venous pressure measuring device 115 that measures the pressure inside the venous air trap chamber 114. A venous protective filter 118f is provided between the venous air trap chamber 114 and the venous pressure measuring device 115. The venous blood circuit 116 is provided with a venous on-off valve 116v that opens and closes the venous blood circuit 116.

[0020] The blood purified by the blood purifier 120 flows through the venous blood circuit 116, has its pressure measured as it passes through the venous air trap chamber 114, and is then returned to the patient's veins. The venous air trap chamber 114 is provided to prevent air from mixing with the blood in the venous blood circuit 116.

[0021] The blood purifier 120 further has a dialysate inlet 124 and a waste fluid outlet 123. A dialysate line 141 is connected to the dialysate inlet 124. A waste fluid line 151 is connected to the waste fluid outlet 123.

[0022] The upstream end of the dialysate conduit 141 is connected to a first supply source 130 that supplies a first fluid 10, which is a replacement fluid and a dialysate. The dialysate conduit 141 is connected to the upstream end of the replacement fluid conduit 131. A dialysate pump 160 that pumps the dialysate is connected to the dialysate conduit 141. The dialysate pump 160 is a peristaltic pump, but may be a roller pump. The dialysate that flows through the dialysate conduit 141 is supplied into the blood purifier 120. A first valve 141v that opens and closes the dialysate conduit 141 is provided upstream of the connection point with the replacement fluid conduit 131 in the dialysate conduit 141. A dialysate heater 170 that heats the dialysate is provided downstream of the dialysate pump 160 in the dialysate conduit 141. Note that the dialysate heater 170 does not necessarily have to be provided.

[0023] A replacement fluid pump 161 that delivers replacement fluid is connected to the replacement fluid line 131. The replacement fluid pump 161 is a peristaltic pump, but may also be a roller pump. A first connecting line 132 through which the first fluid 10 flows is connected to the replacement fluid line 131. A second valve 131v that opens and closes the replacement fluid line 131 is provided upstream of the connection point of the replacement fluid line 131 with the first connecting line 132. A replacement fluid heater 171 that heats the replacement fluid is provided downstream of the replacement fluid pump 161 in the replacement fluid line 131. Specifically, the replacement fluid heater 171 heats the replacement fluid located at a meandering portion 131s that meanders downstream of the replacement fluid pump 161 in the replacement fluid line 131. The replacement fluid heater 171 is arranged to sandwich the meandering portion 131s from both sides.

[0024] In this embodiment, the fluid replacement line 131 is connected to the venous blood circuit 116. Specifically, the fluid replacement line 131 is connected to the venous air trap chamber 114. The fluid replacement line 131 flows into the venous air trap chamber 114. That is, the fluid replacement line 131 supplies the fluid replacement to the venous blood circuit 116. The blood purification device 100 employs a so-called post-dilution method.

[0025] The first connecting pipeline 132 is connected to a first measuring bag 140 that temporarily stores the first liquid 10 and is capable of discharging the stored first liquid 10.

[0026] The drainage pipe 151 discharges the drainage liquid discharged from the blood purifier 120 from the downstream end thereof. A drainage pump 162 is connected to the drainage pipe 151, and sends out the drainage liquid flowing through the drainage pipe 151. The drainage pump 162 is a peristaltic pump, but may also be a roller pump. A second connection pipe 152 through which the drainage liquid flows is connected to the drainage pipe 151. A third valve 151v that opens and closes the drainage pipe 151 is provided in the drainage pipe 151.

[0027] The second connecting pipe 152 is connected to a second measuring bag 150 that temporarily stores the effluent and can discharge the stored effluent. The second connecting pipe 152 is provided with a fourth valve 152v that opens and closes the second connecting pipe 152.

[0028] The first weighing bag 140 and the second weighing bag 150 are housed in the housing portion 181. Each of the first weighing bag 140 and the second weighing bag 150 is a soft bag that does not have any air vent holes formed therein.

[0029] The storage section 181 is connected to a measurement section of the scale 180. In this embodiment, the scale 180 is a load cell. However, the scale 180 is not limited to a load cell and may be a spring balance or the like. The scale 180 measures the overall change in weight of the first weighing bag 140 and the second weighing bag 150. When the fourth valve 152v closes the second connecting conduit 152, the scale 180 can measure the change in weight of the first weighing bag 140.

[0030] The priming solution line 191 is connected between the arterial on-off valve 110v and the blood pump 111 in the arterial blood circuit 110, and supplies the priming solution 20. The priming solution line 191 is provided with a fifth valve 191v that opens and closes the priming solution line 191. The priming solution 20 is, for example, physiological saline.

[0031] The arterial supply / exhaust pipe 117 is connected between the arterial pressure measuring device 113 and the arterial protective filter 117f. The arterial supply / exhaust pipe 117 is provided with an arterial air valve 117v that opens and closes the arterial supply / exhaust pipe 117. The arterial supply / exhaust pipe 117 is configured to be able to exhaust air from the arterial air trap chamber 112 and to supply air into the arterial air trap chamber 112.

[0032] The venous supply / exhaust pipe 118 is connected between the venous pressure measuring device 115 and the venous protective filter 118f. The venous supply / exhaust pipe 118 is provided with a venous air valve 118v that opens and closes the venous supply / exhaust pipe 118. The venous supply / exhaust pipe 118 is configured to be able to exhaust air from the venous air trap chamber 114 and to supply air into the venous air trap chamber 114.

[0033] Each of the arterial protection filter 117f and the venous protection filter 118f has the function of preventing blood from leaking out of the blood circuit and the function of preventing infection from the pressure measuring device.

[0034] 2 is a block diagram showing the electrical connections between the control unit and each component in the blood purification apparatus according to Embodiment 1 of the present invention. As shown in Fig. 2, the control unit 1 included in the blood purification apparatus 100 is electrically connected to each of the blood pump 111, the arterial on-off valve 110v, the venous on-off valve 116v, the first valve 141v, the second valve 131v, the third valve 151v, the fourth valve 152v, the fifth valve 191v, the arterial air valve 117v, the venous air valve 118v, the arterial pressure measuring device 113, the venous pressure measuring device 115, the dialysate pump 160, the replacement fluid pump 161, the drainage pump 162, and the scale 180.

[0035] The control unit 1 receives an input of a venous side measurement value measured by the venous side pressure measuring device 115. In this embodiment, the control unit 1 receives an input of the venous side measurement value, which is the pressure inside the venous side air trap chamber 114 measured by the venous side pressure measuring device 115. The control unit 1 receives an input of a measurement value of the total weight change of the first weighing bag 140 and the second weighing bag 150 measured by the scale 180.

[0036] The control unit 1 controls the operation of each of the blood pump 111, the arterial side opening / closing valve 110v, the venous side opening / closing valve 116v, the first valve 141v, the second valve 131v, the third valve 151v, the fourth valve 152v, the fifth valve 191v, the arterial side air valve 117v, the venous side air valve 118v, the dialysis fluid pump 160, the replacement fluid pump 161, and the drainage pump 162.

[0037] The following describes the operation of priming the venous air trap chamber 114 in the blood purification apparatus 100 according to this embodiment. Fig. 3 is a flowchart showing the operation for priming the venous air trap chamber in the blood purification apparatus according to the first embodiment of the present invention.

[0038] As shown in Figure 3, the control unit 1 performs a first step of pressurizing the blood until the increase in the venous side measurement value exceeds a threshold value by operating the blood pump 111 and closing the venous side opening / closing valve 116v while the replacement fluid pump 161, the dialysis fluid pump 160, and the drainage pump 162 are stopped and the venous side air valve 118v is closed.

[0039] Specifically, the control unit 1 pressurizes the inside of the venous air trap chamber 114 by operating the blood pump 111 and closing the venous side on-off valve 116v in a state in which the replacement fluid pump 161 is stopped, the dialysis fluid pump 160 is stopped, the drainage pump 162 is stopped, the arterial side on-off valve 110v is closed, the first valve 141v is closed, the second valve 131v is closed, the third valve 151v is open, the fourth valve 152v is open, the fifth valve 191v is open, the arterial side air valve 117v is closed, and the venous side air valve 118v is closed (step S1a).

[0040] In the first step, the control unit 1 determines whether the increase in the venous measurement value exceeds a threshold value (step S1b). The threshold value is, for example, 600 Pa or more and 700 Pa or less.

[0041] If the increase in the venous measurement value does not exceed the threshold in step S1b, the control unit 1 returns to step S1a. If the increase in the venous measurement value exceeds the threshold in step S1b, the control unit 1 performs a second step (step S2) of adjusting the liquid level of the priming solution 20 in the venous air trap chamber 114 by opening the venous air valve 118v while keeping the blood pump 111 operating.

[0042] Specifically, in the first step, the pressure inside the venous air trap chamber 114 is increased to exceed the threshold value, and when the venous air valve 118v opens, the air inside the venous air trap chamber 114 is exhausted through the venous protective filter 118f and the venous supply / exhaust pipe 118, and the priming solution 20 delivered by the blood pump 111 flows into the venous air trap chamber 114.

[0043] After the second step, the control unit 1 performs a third step (step S3) of depressurizing the venous air trap chamber 114 and the serpentine portion 131s by stopping the blood pump 111 while keeping the venous air valve 118v open. This reduces the pressure in the venous air trap chamber 114 and the serpentine portion 131s to approximately atmospheric pressure.

[0044] By performing the above steps, it is possible to prevent air from being compressed in the serpentine portion 131s of the fluid replacement line 131 when priming the venous air trap chamber 114, thereby preventing a portion of the air compressed in the serpentine portion 131s from passing through the venous air trap chamber 114 and flowing into the blood purifier 120. Furthermore, because the pressure in the serpentine portion 131s is reduced to approximately atmospheric pressure, even if the venous on-off valve 116v is opened, it is possible to prevent the priming solution 20 in the venous air trap chamber 114 from flowing out due to the pressure in the serpentine portion 131s. Furthermore, in the blood purification device 100 according to this embodiment, no check valve is provided between the venous air trap chamber 114 and the serpentine portion 131s, so the serpentine portion 131s can be kept cleanable with the priming solution 20.

[0045] (Embodiment 2) A blood purification apparatus according to a second embodiment of the present invention will be described below with reference to the drawings. The blood purification apparatus according to the second embodiment of the present invention differs from the blood purification apparatus 100 according to the first embodiment of the present invention mainly in that a replacement fluid line is connected to the arterial blood circuit and the arterial air trap chamber is primed. Therefore, the same configuration as that of the blood purification apparatus 100 according to the first embodiment of the present invention will not be described again.

[0046] Fig. 4 is a circuit diagram showing the configuration of a blood purification apparatus according to Embodiment 2 of the present invention. As shown in Fig. 4, the blood purification apparatus 200 according to Embodiment 2 of the present invention includes a blood purifier 120, an arterial blood circuit 110, a venous blood circuit 116, a replacement fluid line 131, a dialysate line 141, a drainage line 151, a blood pump 111, an arterial air trap chamber 112, an arterial on-off valve 110v, a venous air trap chamber 114, a venous on-off valve 116v, a priming fluid line 191, a replacement fluid pump 161, a dialysate pump 160, a drainage pump 162, a first measuring bag 140, a replacement fluid heater 171, an arterial pressure measuring device 113, an arterial protective filter 117f, an arterial supply / exhaust line 117, an arterial air valve 117v, and a controller.

[0047] The blood purification apparatus 200 further includes a venous pressure measuring device 115, a venous protective filter 118f, a venous supply / exhaust line 118, a venous air valve 118v, a first supply source 130, a dialysate heater 170, a scale 180, a priming solution supply source 190, a first connecting line 132, a second connecting line 152, a second measuring bag 150, a first valve 141v, a second valve 131v, a third valve 151v, a fourth valve 152v, and a fifth valve 191v.

[0048] In the blood purification apparatus 200 according to the second embodiment of the present invention, the fluid replacement line 131 is connected to the arterial blood circuit 110. Specifically, the fluid replacement line 131 is connected to the arterial air trap chamber 112. The fluid replacement line 131 supplies the fluid replacement to the arterial blood circuit 110. The blood purification apparatus 200 employs a so-called pre-dilution method. An arterial measurement value, which is the pressure in the arterial air trap chamber 112 measured by the arterial pressure measuring device 113, is input to the control unit 1.

[0049] The following describes the operation of priming the arterial air trap chamber 112 in the blood purification apparatus 200 according to this embodiment. Fig. 5 is a flowchart showing the operation for priming the arterial air trap chamber in the blood purification apparatus according to embodiment 2 of the present invention.

[0050] As shown in Figure 5, the control unit 1 performs a first step of pressurizing the arterial side measurement value until the increase in the arterial side measurement value exceeds a threshold value by operating the blood pump 111 and closing the venous side opening / closing valve 116v while the replacement fluid pump 161, the dialysis fluid pump 160, and the drainage pump 162 are stopped and the arterial side air valve 117v is closed.

[0051] Specifically, the control unit 1 pressurizes the inside of the arterial side air trap chamber 112 by operating the blood pump 111 and closing the venous side on-off valve 116v in a state in which the replacement fluid pump 161 is stopped, the dialysis fluid pump 160 is stopped, the drainage pump 162 is stopped, the arterial side on-off valve 110v is closed, the first valve 141v is closed, the second valve 131v is closed, the third valve 151v is open, the fourth valve 152v is open, the fifth valve 191v is open, the arterial side air valve 117v is closed, and the venous side air valve 118v is closed (step S11a).

[0052] In the first step, the control unit 1 determines whether or not the increase in the arterial measurement value exceeds a threshold value (step S11b). The threshold value is, for example, 600 Pa or more and 700 Pa or less.

[0053] If the increase in the arterial measurement value does not exceed the threshold in step S11b, the control unit 1 returns to step S11a. If the increase in the arterial measurement value exceeds the threshold in step S11b, the control unit 1 performs a second step (step S12) of adjusting the liquid level of the priming solution 20 in the arterial air trap chamber 112 by opening the arterial air valve 117v while keeping the blood pump 111 operating.

[0054] Specifically, in the first step, the pressure inside the arterial side air trap chamber 112 is increased to exceed the threshold value, and when the arterial side air valve 117v opens, the air inside the arterial side air trap chamber 112 is exhausted through the arterial side protective filter 117f and the arterial side supply / exhaust pipe 117, and the priming solution 20 delivered by the blood pump 111 flows into the arterial side air trap chamber 112.

[0055] After the second step, the control unit 1 performs a third step (step S13) of depressurizing the arterial air trap chamber 112 and the serpentine portion 131s by stopping the blood pump 111 while keeping the arterial air valve 117v open. This reduces the pressure in the arterial air trap chamber 112 and the serpentine portion 131s to approximately atmospheric pressure.

[0056] By performing the above steps, it is possible to prevent air from being compressed in the serpentine portion 131s of the fluid replacement line 131 when priming the arterial air trap chamber 112, thereby preventing a portion of the air compressed in the serpentine portion 131s from passing through the arterial air trap chamber 112 and flowing into the blood purifier 120. Furthermore, because the pressure in the serpentine portion 131s is reduced to approximately atmospheric pressure, it is possible to prevent the priming solution 20 in the arterial air trap chamber 112 from flowing out due to the pressure in the serpentine portion 131s, even if the venous on-off valve 116v is opened. Furthermore, in the blood purification device 200 according to this embodiment, no check valve is provided between the arterial air trap chamber 112 and the serpentine portion 131s, so the serpentine portion 131s can be kept cleanable with the priming solution 20.

[0057] The embodiments disclosed herein should be considered to be illustrative in all respects and not restrictive. The scope of the present invention is defined by the claims, not by the above description, and is intended to include all modifications within the meaning and scope of the claims. [Explanation of symbols]

[0058] 1 control unit, 10 first fluid, 20 priming fluid, 100, 200 blood purification device, 110 arterial blood circuit, 110v arterial on-off valve, 111 blood pump, 112 arterial air trap chamber, 113 arterial pressure measuring device, 114 venous air trap chamber, 115 venous pressure measuring device, 116 venous blood circuit, 116v venous on-off valve, 117 arterial supply and exhaust line, 117f arterial protection filter, 117v arterial air valve, 118 venous supply and exhaust line, 118f venous protection filter, 118v venous air valve, 120 blood purifier, 121 blood inlet, 122 blood outlet, 123 drainage outlet, 124 dialysis fluid inlet, 130 first supply source, 131 replacement fluid line, 131s Serpentine section, 131v Second valve, 132 First connecting line, 140 First measuring bag, 141 Dialysis fluid line, 141v First valve, 150 Second measuring bag, 151 Drainage line, 151v Third valve, 152 Second connecting line, 152v Fourth valve, 160 Dialysis fluid pump, 161 Replacement fluid pump, 162 Drainage pump, 170 Dialysis fluid heater, 171 Replacement fluid heater, 180 Scale, 181 Storage section, 190 Primer fluid supply source, 191 Primer fluid line, 191v Fifth valve.

Claims

1. Blood purifier and an arterial blood circuit connected to the blood purifier for allowing blood to flow into the blood purifier; a venous blood circuit connected to the blood purifier for allowing blood to flow out of the blood purifier; a fluid replacement line connected to the venous blood circuit and supplying a replacement fluid; a dialysate line for supplying dialysate to the blood purifier; a drainage pipe through which the drainage liquid discharged from the blood purifier flows; a blood pump provided in the arterial blood circuit for pumping blood; an arterial air trap chamber provided in the arterial blood circuit; an arterial on-off valve provided in the arterial blood circuit for opening and closing the arterial blood circuit; a venous air trap chamber provided in the venous blood circuit and connected to the replacement fluid line; a venous on-off valve provided in the venous blood circuit for opening and closing the venous blood circuit; a priming solution line connected to the arterial blood circuit between the arterial on-off valve and the blood pump, for supplying a priming solution; a replacement fluid pump provided in the replacement fluid line and configured to pump out the replacement fluid; a dialysate pump provided in the dialysate line for pumping the dialysate; a drainage pump provided in the drainage pipeline for pumping out the drainage liquid; a first measuring bag connected to the replacement fluid line, which temporarily stores the replacement fluid and can deliver the stored replacement fluid; a heater for heating the replacement fluid located at a meandering portion of the replacement fluid conduit downstream of the replacement fluid pump; a venous pressure measuring device for measuring the pressure in the venous air trap chamber; a venous protection filter provided between the venous air trap chamber and the venous pressure measuring device; a venous supply / exhaust pipe connected between the venous pressure measuring device and the venous protection filter; a venous air valve provided in the venous air supply / exhaust pipe for opening and closing the venous air supply / exhaust pipe; a control unit to which a venous pressure measured by the venous pressure measuring device is input, When priming the venous air trap chamber, the control unit a first step of pressurizing the blood until an increase in the venous measurement value exceeds a threshold value by operating the blood pump while the replacement fluid pump, the dialysate pump, and the drainage pump are stopped and the venous air valve is closed, and closing the venous on-off valve; After the first step, a second step is carried out in which the venous air valve is opened while the blood pump is operating to adjust the liquid level of the priming solution in the venous air trap chamber; After the second step, a third step is carried out in which the blood pump is stopped while the venous air valve is kept open, thereby reducing the pressure inside the venous air trap chamber and the meandering section.

2. Blood purifier and an arterial blood circuit connected to the blood purifier for allowing blood to flow into the blood purifier; a venous blood circuit connected to the blood purifier for allowing blood to flow out of the blood purifier; a fluid replacement line connected to the arterial blood circuit and supplying a replacement fluid; a dialysate line for supplying dialysate to the blood purifier; a drainage pipe through which the drainage liquid discharged from the blood purifier flows; a blood pump provided in the arterial blood circuit for pumping blood; an arterial air trap chamber provided in the arterial blood circuit and connected to the fluid replacement line; an arterial on-off valve provided in the arterial blood circuit for opening and closing the arterial blood circuit; a venous air trap chamber provided in the venous blood circuit; a venous on-off valve provided in the venous blood circuit for opening and closing the venous blood circuit; a priming solution line connected to the arterial blood circuit between the arterial on-off valve and the blood pump, for supplying a priming solution; a replacement fluid pump provided in the replacement fluid line and configured to pump out the replacement fluid; a dialysate pump provided in the dialysate line for pumping the dialysate; a drainage pump provided in the drainage pipeline for pumping out the drainage liquid; a first measuring bag connected to the replacement fluid line, which temporarily stores the replacement fluid and can deliver the stored replacement fluid; a heater for heating the replacement fluid located at a meandering portion of the replacement fluid conduit downstream of the replacement fluid pump; an arterial pressure measuring device for measuring the pressure in the arterial air trap chamber; an arterial side protection filter provided between the arterial side air trap chamber and the arterial side pressure measuring device; an arterial supply / exhaust pipe connected between the arterial pressure measuring device and the arterial protection filter; an arterial air valve provided in the arterial air supply / exhaust pipe for opening and closing the arterial air supply / exhaust pipe; a control unit to which an arterial pressure measurement value measured by the arterial pressure measuring device is input, When priming the arterial air trap chamber, the control unit a first step of pressurizing the arterial blood until an increase in the arterial blood pressure measurement value exceeds a threshold value by operating the blood pump while the replacement fluid pump, the dialysis fluid pump, and the drainage pump are stopped and the arterial blood valve is closed, and closing the venous blood valve; After the first step, a second step is carried out in which the arterial air valve is opened while the blood pump is operating, thereby adjusting the liquid level of the priming solution in the arterial air trap chamber; After the second step, a third step is carried out in which the pressure in the arterial air trap chamber and the meandering section is reduced by stopping the blood pump while keeping the arterial air valve open.

3. The blood purification apparatus according to claim 1 or 2, wherein the threshold value is 600 Pa or more and 700 Pa or less.

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