Topical skin components

Abstract

To provide a skin external composition which can impart a dry feeling without stickiness when applied to the body and can maintain stable properties without causing separation or the like even when a hydrophilic medicinal component is blended while containing a hydrocarbon such as vaseline having a predetermined melting point and cornstarch.SOLUTION: There is provided a skin external composition which comprises 30 to 70 wt.% of a primary hydrocarbon having a melting point of 30 to 60°C, 20 to 40 wt,% of cornstarch dispersed in the primary hydrocarbon, 0.1 to 5.0 wt.% of a hydrophilic medicinal component, 1 to 10 wt.% of water and 1 to 10 wt.% of a glycol having 2 to 10 carbon atoms.SELECTED DRAWING: None

Description

[Technical Field]

[0001] The present invention relates to a composition for external use on the skin that is applied to the fingers and trunk of the body to suppress evaporation of moisture and thereby moisturize the skin. [Background technology]

[0002] Conventionally, various external skin compositions have been known that are applied to the body, such as fingers, hands, arms, feet, legs, and trunk, to moisturize the skin and prevent dryness. However, while some compositions generally contain cyclic silicones to provide a non-sticky, dry feel after application, they are difficult to wash off because they are poorly compatible with both oil and water, and in recent years, non-silicone products that do not contain silicone compounds have been popular among consumers, making it difficult to incorporate silicone compounds.

[0003] To solve this stickiness problem, for example, Patent Document 1 describes a topical skin composition that does not contain a silicone-based compound but contains a hydrocarbon such as petrolatum having a predetermined melting point and a granular agent, and that can impart a non-sticky, smooth feel to the touch after application to the body, such as fingers, hands, arms, feet, legs, and trunk. It is disclosed that this topical skin composition imparts a non-sticky, smooth feel to the touch when applied to the skin, even though it does not contain a silicone-based compound. [Prior art documents] [Patent documents]

[0004] [Patent Document 1] Japanese Patent Application Publication No. 2019-23177 Summary of the Invention [Problem to be solved by the invention]

[0005] However, although the invention of Patent Document 1 does not contain silicone compounds and can provide a smooth feel after application, it contains hydrocarbons such as petrolatum, which have a certain melting point, and granular agents, so when hydrophilic medicinal ingredients are added to impart medicinal effects, they sometimes separate, making it difficult to produce a stable formulation.

[0006] Therefore, the present invention aims to provide a skin topical composition that contains a hydrocarbon such as petrolatum and cornstarch having a predetermined melting point, yet is non-sticky and provides a smooth feel when applied to the body, and that maintains stable properties such as not separating even when hydrophilic medicinal ingredients are incorporated. [Means for solving the problem]

[0007] [1] That is, the present invention provides a composition for external use on skin, characterized by containing 30 to 70% by weight of a first hydrocarbon having a melting point of 30 to 60°C, 20 to 50% by weight of cornstarch dispersed in the first hydrocarbon, 0.1 to 5.0% by weight of a hydrophilic medicinal ingredient, 1 to 8% by weight of water, and 1 to 8% by weight of a glycol having 2 to 10 carbon atoms.

[0008] [2] The topical skin composition according to [1], wherein the hydrophilic medicinal ingredient is at least one selected from the group consisting of heparinoids, allantoin, glycyrrhizinic acid, glycyrrhizinate salts, and panthenol.

[0009] [3] The topical skin composition according to [1] or [2], wherein the glycol is at least one selected from butylene glycol, propylene glycol, and dipropylene glycol.

[0010] [4] And the kinematic viscosity at 37.8℃ is 10 to 80 mm 2 The composition for external use on skin according to [1] or [2] above, characterized in that it contains a secondary hydrocarbon having a molecular weight of 1 / sec. [Effects of the Invention]

[0011] According to the present invention, even though the composition contains hydrocarbons such as petrolatum and cornstarch having a predetermined melting point, it is possible to provide a smooth and dry feel when applied to the body without stickiness, and it is possible to maintain stable properties that do not separate even when hydrophilic medicinal ingredients are blended. DETAILED DESCRIPTION OF THE INVENTION

[0012] Hereinafter, embodiments of the topical skin composition of the present invention will be described in detail. Note that when the notation "to" indicates a range in the description, it includes both the upper and lower limits.

[0013] The first hydrocarbon in the present invention is a compound having a melting point of 30 to 60°C, and is a semi-solid compound that is solid at room temperature or maintains its shape but deforms when force is applied. The first hydrocarbon enhances skin moisture retention and prevents the granular agent from settling in the short term, allowing the granular agent to be uniformly dispersed for a relatively long period of time.

[0014] Specifically, the first hydrocarbon is preferably a hydrocarbon consisting of a straight-chain hydrocarbon, a branched-chain hydrocarbon, or an alicyclic hydrocarbon, such as petrolatum or solid paraffin. These first hydrocarbons can be used alone or in combination of two or more.

[0015] The content of the first hydrocarbon in the composition for external use on skin is preferably 30 to 70 wt %, more preferably 35 to 65 wt %. When the content of the first hydrocarbon is within the above range, evaporation of water from the skin can be suppressed when the composition for external use on skin is applied to the skin, thereby enhancing the moisturizing effect.

[0016] The cornstarch in the present invention is a starch produced from corn and is a granular material dispersed in at least a primary hydrocarbon. The cornstarch can suppress stickiness and greasiness when the topical skin composition is applied to the skin.

[0017] The particle size of the cornstarch is preferably 1 to 50 μm, and more preferably 2 to 35 μm. When the particle size of the cornstarch is within the above range, the topical skin composition can be applied to the skin without stickiness and with a smooth feel, and the reflection of light due to the primary hydrocarbon can be suppressed, preventing shine. The particle size is measured by microscopic examination using an optical microscope.

[0018] The content of cornstarch in the topical skin composition is preferably 20 to 50% by weight, more preferably 25 to 45% by weight. When the content of cornstarch is within the above range, the topical skin composition can provide a non-sticky, smooth feel when applied to the skin, can suppress light reflection due to the first hydrocarbon, preventing shine, and makes the topical skin composition easier to spread when applied.

[0019] The hydrophilic medicinal ingredient in the present invention is a compound that exhibits medicinal efficacy in the human body and is soluble in water. Specific examples of the hydrophilic medicinal ingredient include heparinoids, allantoin, glycyrrhizinic acid, glycyrrhizinate, and panthenol. These hydrophilic medicinal ingredients can be used alone or in combination of two or more.

[0020] The content of the hydrophilic medicinal ingredient in the composition for external use on skin is preferably 0.1 to 5.0% by weight, more preferably 0.2 to 3.0% by weight. When the content of the hydrophilic medicinal ingredient is within the above range, the medicinal effects of the hydrophilic medicinal ingredient can be imparted when the composition for external use on skin is applied to the skin.

[0021] The water in the present invention is a solvent for dissolving hydrophilic medicinal ingredients, and can be mixed as a liquid into the composition for topical skin application even if the hydrophilic medicinal ingredient is solid at room temperature of 20 to 25° C. As the water, water conforming to the Japanese Pharmacopoeia standard is preferred, and examples thereof include tap water such as tap water and well water, purified water obtained by treating tap water by distillation, ion exchange treatment using an ion exchange membrane, ultrafiltration treatment using an ultrafiltration membrane, or a combination thereof, and sterilized purified water obtained by sterilizing purified water by heating or the like.

[0022] The content of water in the composition for external use on skin is preferably 1 to 8% by weight, more preferably 2 to 7% by weight. When the content of water is within the above range, the hydrophilic medicinal ingredients can be sufficiently dissolved, the water is readily available because it is a general-purpose ingredient, and there are no safety issues when used on the skin as an external preparation.

[0023] The glycol having 2 to 10 carbon atoms in the present invention is a solvent for uniformly dispersing the hydrophilic medicinal ingredient in the composition for external use on skin, and can stabilize the hydrophilic medicinal ingredient so that it does not separate. Specific examples of glycols having 2 to 10 carbon atoms include butylene glycol, propylene glycol, and dipropylene glycol. These glycols having 2 to 10 carbon atoms can be used alone or in combination of two or more.

[0024] The content of the glycol having 2 to 10 carbon atoms in the composition for external use on skin is preferably 1 to 8 wt %, more preferably 2 to 7 wt %. When the content of the glycol having 2 to 10 carbon atoms is within the above range, the hydrophilic medicinal ingredient is stably and uniformly dispersed in the composition for external use on skin without separation or the like.

[0025] The second hydrocarbon in the present invention has a kinematic viscosity of 10 to 80 mm at 37.8°C. 2 / sec, and is a liquid compound at room temperature (20-25°C). If necessary, the second hydrocarbon can be uniformly dispersed in the topical skin composition to soften the hardness of the topical skin composition, imparting a smooth, dry feel to the skin when applied to the body in accordance with the season. If the second hydrocarbon has a kinematic viscosity below the above range, the topical skin composition will be too soft, resulting in a sticky feel after application to the body, and failing to impart a smooth, dry feel to the skin. If the kinematic viscosity exceeds the above range, the topical skin composition will be too hard, making it difficult to spread when applied to the body in cold seasons. The kinematic viscosity is measured according to the method specified in JIS K 2283, the Japanese Pharmacopoeia, etc.

[0026] The content of the second hydrocarbon in the composition for external use on skin is preferably 0 to 40 wt %, more preferably 3 to 35 wt %. When the content of the second hydrocarbon is within this range, in combination with the above-mentioned kinematic viscosity of the second hydrocarbon, it is possible to prepare a composition for external use on skin that is easy to spread when applied to the body, such as fingers, hands, arms, feet, legs, and trunk, even in cold or hot seasons, and that imparts a smooth, non-sticky feel to the touch, and is not significantly affected by temperature changes. [Example]

[0027] Example 1 The mixture consisted of 30 parts by weight of petrolatum (Sonneborn, Snowwhite Special) having a melting point of 50 to 60°C as the first hydrocarbon, 30 parts by weight of cornstarch (Nippon Cornstarch Co., Ltd., Cornstarch White) having a particle size of 2 to 35 μm, 0.3 parts by weight of a heparinoid as a hydrophilic active ingredient, 3 parts by weight of water, 3 parts by weight of butylene glycol as a glycol having 2 to 10 carbon atoms, and liquid paraffin (Sanko Chemical Industry, Liquid Paraffin No. 70-S, kinematic viscosity at 37.8°C: 14 mm) as the second hydrocarbon. 2 A total of 100 parts by weight of the composition was prepared with a concentration of 33.7 parts by weight of ethanol / sec, and the composition was heated in a hot water bath and thoroughly mixed so that each component was uniformly dispersed to prepare a composition for external use on the skin.

[0028] Examples 2 to 16 As in Example 1, a composition for external use on skin was prepared using the components and amounts listed in Table 1.

[0029] Comparative Examples 1 to 5 As in Example 1, a composition for external use on skin was prepared using the components and amounts listed in Table 2.

[0030] The appearance, physical properties and feel of the topical skin compositions prepared as described above were visually inspected for properties after preparation, visually inspected for stability, and subjected to sensory evaluation of ease of spreading after storage at 25°C.

[0031] [Properties] The skin topical composition immediately after preparation was placed in a 50 ml screw tube, and the condition at that time was visually confirmed. The condition was rated as O when the solids were not dispersed and rough, and when the oil and water were not separated, and the condition was uniform and smooth, and X when either the solids were not dispersed and rough, or when the oil and water were separated, was observed. The evaluation was performed with "O" being preferable and "X" being unfavorable.

[0032] [Storage stability] The prepared skin topical compositions were placed in 50 ml screw tubes and stored at 30° C. for one day, after which the condition was visually inspected. A state in which no solids were dispersed and there was no rough texture, or no separation of oil and water, was rated as ○, and a state in which any one of the following was observed: no solids were dispersed and there was no rough texture, or no separation of oil and water, was rated ×, with “○” being preferable and “×” being unfavorable.

[0033] [Ease of stretching] Sensory evaluation was performed on the ease of spreadability after storage at 25°C. Specifically, five expert panelists stored the prepared topical skin compositions in a thermostatic chamber at 25°C for at least one day, and then 0.2 g of each composition was taken out and applied to the forearm under that environment. The sensory evaluation was performed on a 5-point scale from 1 to 5 for ease of spreadability, and the evaluation was scored and judged. When evaluating the ease of spreadability of the prepared topical skin compositions, the evaluation criteria were as follows: very easy to spread: 5 points, easy to spread: 4 points, somewhat easy to spread: 3 points, not very easy to spread: 2 points, and no easy to spread: 1 point. An average score of 3.5 or more by each panelist was rated as ◯, an average score of 2.0 to less than 3.5 was △, and an average score of less than 2.0 was rated x. A rating of "◯" was preferable, and ratings of "△" and "x" were unfavorable.

[0034] [Sticky] A sensory evaluation was performed on the stickiness after storage at 25°C. Specifically, similar to the evaluation of ease of spreadability, five expert panelists stored the prepared topical skin compositions in a thermostatic chamber at 25°C for at least one day, and then applied 0.2 g of each composition to the forearm under that environment. The stickiness was evaluated on a 5-point scale from 1 to 5, and judged as a score. When evaluating the stickiness of the prepared topical skin compositions, the evaluation criteria were as follows: no feeling: 5 points, not much feeling: 4 points, some feeling: 3 points, feeling: 2 points, very feeling: 1 point. The panelists' average score of 3.5 or more was rated as ◯, an average score of 2.0 or more but less than 3.5 was △, and an average score of less than 2.0 was rated x. The "◯" rating was preferable, and the "△" and "x" ratings were unfavorable.

[0035] The results regarding the properties, storage stability, ease of spreading, and stickiness for Examples 1 to 16 and Comparative Examples 1 to 5 are shown in Tables 1 and 2, respectively. Note that for Comparative Examples 1 and 2, the properties immediately after production were not favorable, so other evaluations were not performed.

[0036] [Table 1]

[0037] [Table 2]

[0038] As shown in Tables 1 and 2, a composition prepared by uniformly mixing specified petrolatum, cornstarch, hydrophilic medicinal ingredients, water, and glycols having 2 to 10 carbon atoms in a specific range of blending ratios had a uniform and smooth texture immediately after preparation, maintained this uniform state for a specified period of time, and was found to be highly stable. When applied to the skin, it was also found to be easy to spread and to provide a smooth, non-sticky feel.

Claims

1. 30 to 70 wt % of a first hydrocarbon having a melting point of 30 to 60°C; 20 to 50% by weight of corn starch dispersed in the first hydrocarbon; The hydrophilic medicinal ingredient is 0.1 to 5.0% by weight, 1 to 8% by weight of water, Glycols having 2 to 10 carbon atoms are contained in an amount of 1 to 8% by weight. A composition for external use on the skin, characterized by comprising:

2. 2. The composition for external use on skin according to claim 1, wherein the hydrophilic medicinal ingredient is at least one selected from the group consisting of heparinoids, allantoin, glycyrrhizinic acid, glycyrrhizinate salts, and panthenol.

3. 3. The composition for external use on skin according to claim 1, wherein the glycol is at least one selected from butylene glycol, propylene glycol, and dipropylene glycol.

4. Kinematic viscosity at 37.8°C is 10 to 80 mm 2 3. The composition for external use on skin according to claim 1 or claim 2, characterized in that it contains a secondary hydrocarbon of which the formula is / sec.

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