Specimen testing equipment and specimen testing method

Abstract

A sample testing device according to one embodiment of the present invention includes a sample reaction unit that includes a plurality of chambers each containing a different test reagent, in which a solution containing a sample is provided in each of the chambers and the sample reacts with the test reagent; an optical unit that moves sequentially along the arrangement direction of the plurality of chambers, irradiating a diagnostic beam to each of the chambers and receiving an optical signal from each of the chambers; and a diagnostic unit that obtains a plurality of reaction data for one sample based on the optical signal corresponding to the wavelength of the test reagent and the diagnostic beam, and outputs a test result for the sample based on the reaction data.

Description

Technical Field

[0001] The present invention relates to a specimen inspection apparatus and a specimen inspection method, and more particularly to a specimen inspection apparatus and a specimen inspection method capable of continuously performing various types of specimen reaction inspections on a single specimen according to the wavelengths of a test reagent and a diagnostic beam.

Background Art

[0002] Generally, with the development of medicine and various related technologies, substances such as blood cells, nucleic acids, proteins, and antigens contained in a predetermined biological sample such as blood are being examined. After collecting a sample as described above, by analyzing and observing the changes that occur after reacting the collected sample with a predetermined reagent, it is possible to perform inspections such as the presence or absence, ratio, and quantity of various substances contained in the sample, and thereby obtain information regarding the presence or absence of a disease, the state of a disease, and the like.

[0003] In such a sample inspection process, it is very important to obtain accurate and reproducible results by ensuring that the sample and the reagent used for the sample inspection are not affected by external factors and are used in accurate amounts each time. In the inspection process, since the sample and the reagent may be exposed to the outside, it is necessary to effectively prevent contamination due to such exposure of the sample and the reagent and ensure the accuracy of the inspection by using accurate amounts.

[0004] In addition, it is also necessary to reduce the inspection time and inspection cost and reduce the steps and costs involved in the overall inspection so that the detection and reading / analysis of the reaction product after the reaction between the reagent and the sample can be accurately and quickly performed under one integrated system.

Summary of the Invention

Problems to be Solved by the Invention

[0005] An object of the present invention is to provide a specimen inspection apparatus and a specimen inspection method capable of continuously performing various types of specimen reaction inspections on a single specimen according to the wavelengths of a test reagent and a diagnostic beam. [Means for solving the problem]

[0006] A specimen testing apparatus according to one embodiment of the present invention includes a plurality of chambers each containing different test reagents, a specimen reaction unit in which a dissolving solution containing a specimen is provided to each chamber and the specimen reacts with the test reagent; an optical unit that irradiates each chamber with a diagnostic beam while sequentially moving along the arrangement direction of the plurality of chambers and receives an optical signal from each chamber; and a diagnostic unit that acquires a plurality of reaction data for a single specimen based on the optical signal corresponding to the wavelength of the test reagent and the diagnostic beam, and outputs a test result for the specimen based on the reaction data.

[0007] Furthermore, each of the aforementioned chambers is provided with a light source incidence section that protrudes laterally, and the optical section is configured to direct the diagnostic beam into the light source incidence section.

[0008] Furthermore, the optical unit may include a transport unit installed alongside the sample reaction unit, and a plurality of optical units coupled to the transport unit that sequentially move along the arrangement direction of the chambers, irradiating each of the chambers with the diagnostic beam and acquiring the optical signal received for each of the chambers.

[0009] Furthermore, the plurality of optical units include a first optical unit that emits a first diagnostic beam and a second optical unit arranged alongside the first optical unit that emits a second diagnostic beam, and the first diagnostic beam and the second diagnostic beam may have different fluorescence wavelengths.

[0010] The fluorescence wavelength may include at least one selected from FAM, HEX, ROX, or Cy5, wherein the FAM fluorescence wavelength may have an emission wavelength in the range of 510 nm to 530 nm, the HEX fluorescence wavelength may have an emission wavelength in the range of 550 nm to 580 nm, the ROX fluorescence wavelength may have an emission wavelength in the range of 595 nm to 635 nm, and the Cy5 fluorescence wavelength may have an emission wavelength in the range of 655 nm to 675 nm.

[0011] Furthermore, the first optical unit is configured to sequentially move along the arrangement direction of the multiple chambers, irradiating each of the chambers with the first diagnostic beam, and acquiring an optical signal for the first diagnostic beam for each chamber.

[0012] Furthermore, the second optical unit is configured to sequentially move along the arrangement direction of the multiple chambers, irradiating each of the chambers with the second diagnostic beam, and acquiring an optical signal for the second diagnostic beam for each chamber.

[0013] Furthermore, the plurality of optical units may further include a third optical unit that is arranged alongside the second optical unit along the arrangement direction of the chamber and irradiates a third diagnostic beam. The third diagnostic beam may also have a different wavelength from the first and second diagnostic beams.

[0014] Furthermore, the third optical unit is configured to sequentially move along the arrangement direction of the multiple chambers, irradiating each of the chambers with the third diagnostic beam, and acquiring an optical signal for the third diagnostic beam for each chamber.

[0015] Furthermore, the plurality of optical units may further include a fourth optical unit that is arranged alongside the third optical unit in the arrangement direction of the chamber and irradiates a fourth diagnostic beam. The fourth diagnostic beam may also have a different wavelength from the first to third diagnostic beams.

[0016] Furthermore, the fourth optical unit is configured to sequentially move along the arrangement direction of the multiple chambers, irradiating each of the chambers with the fourth diagnostic beam, and to acquire an optical signal for the fourth diagnostic beam for each chamber.

[0017] Furthermore, the transfer unit may include a drive unit comprising a transfer rail installed in line with the sample reaction section in the direction of the arrangement of the plurality of chambers, a transfer belt installed spaced apart from the sample reaction section in line with the transfer rail, a pair of drive pulleys installed at both ends of the transfer belt, and a drive motor that provides rotational force to one of the drive pulleys, a transfer member whose upper end is connected to the plurality of optical units and whose lower end is connected to the transfer belt, and which is connected to the transfer rail so as to be movable along the transfer rail when the transfer belt is operating, and a chain member installed spaced apart from the transfer belt on either side of the transfer rail, connected to the transfer member, and guiding the movement of the transfer member.

[0018] Furthermore, the sample reaction section may include a container mounting section into which a vial container containing a dissolving solution mixed with the sample is inserted; a reagent reaction section in which the plurality of chambers are arranged in a row spaced apart; a dissolving solution distribution section that penetrates the lower end of the vial container and is inserted into the vial container to supply the dissolving solution and distribute the dissolving solution to each of the chambers; and a gasket member that is stacked between the dissolving solution distribution section and the reagent reaction section and covers each of the chambers, with guide pins passing through each chamber to guide the flow of the dissolving solution and provided to allow air to flow into the chambers.

[0019] Furthermore, the sample reaction unit may further include a heating unit that provides heat to each of the chambers from the bottom of the reagent reaction unit and operates so that each of the chambers is kept isothermally at a pre-set temperature, and a heat dissipation unit coupled to the heating unit to dissipate heat from the heating unit.

[0020] Furthermore, the dissolution distribution unit is provided corresponding to the reagent reaction unit and includes a distribution plate with an inlet hole that penetrates vertically through the center, an inlet section provided coaxially with the inlet hole and protruding vertically from the top of the distribution plate and insertable into the vial container, a reference channel connected to the inlet hole on the lower surface of the distribution plate, and a plurality of branch channels branching off from the reference channel, a channel section that guides the flow of the dissolution that flows into the inlet hole, a plurality of guide pins provided that protrude vertically from the bottom of the distribution plate from the end of each of the branch channels corresponding to the arrangement of the plurality of chambers, and a plurality of air holes that penetrate vertically through the distribution plate but are provided corresponding to the arrangement of each of the guide pins, and the dissolution distribution unit is laminated and bonded to the reagent reaction unit such that each of the guide pins is inserted into each of the chambers and each of the air holes is connected to each of the chambers.

[0021] Furthermore, the guide pin has a pin groove along its longitudinal direction on one side that connects to the branch channel, which can guide the flow of the dissolving liquid through the branch channel.

[0022] Furthermore, each of the aforementioned air holes is provided on the opposite side of the surface where the pin groove is located, and is positioned so as to be separated from the end of the branch channel, with each of the aforementioned guide pins in between.

[0023] Furthermore, the multiple branch channels are arranged symmetrically with respect to the inlet hole, branching off from the reference channel and curving with a predetermined curvature in a direction away from the inlet hole.

[0024] Further, the distribution plate is provided with a plurality of air grooves having a diameter larger than the diameter of each of the air holes and corresponding to the arrangement of each of the air holes, and further includes a filter member provided with a plurality of filter protrusions inserted into each of the air grooves and covering each of the air holes.

Advantages of the Invention

[0025] As described above, according to the specimen inspection apparatus according to at least one embodiment of the present invention, various types of specimen reaction inspections can be continuously performed on one specimen according to the test reagent and the wavelength of the diagnostic beam, and the speed and efficiency of the inspection on the specimen can be improved.

[0026] In addition, a light source incident portion is provided on one side of the chamber, the incident distance of the diagnostic beam can be shortened, and the accuracy of the inspection can be improved.

Brief Description of the Drawings

[0027] [Figure 1] It is a diagram schematically showing a configuration diagram of a specimen inspection apparatus according to an embodiment of the present invention.

[0028] [Figure 2] It is a diagram schematically showing a perspective view of a specimen inspection apparatus according to an embodiment of the present invention. [Figure 3] It is a diagram schematically showing a perspective view of a specimen inspection apparatus according to an embodiment of the present invention.

[0029] [Figure 4] It is a diagram for explaining an optical unit according to an embodiment of the present invention. [Figure 5] It is a diagram for explaining an optical unit according to an embodiment of the present invention.

[0030] [Figure 6] It is a diagram for schematically explaining the operating state of an optical portion according to an embodiment of the present invention.

[0031] [Figure 7] This figure schematically shows a perspective view of an inspection cartridge according to one embodiment of the present invention.

[0032] [Figure 8] This figure schematically shows a cross-sectional view of line XX in Figure 7.

[0033] [Figure 9] This figure schematically shows an exploded perspective view of an inspection cartridge according to one embodiment of the present invention.

[0034] [Figure 10] This diagram schematically shows the connection between the reagent reaction section, the gasket member, and the dissolving solution distribution section, as viewed from the rear, with the container mounting section removed from the test cartridge according to one embodiment of the present invention.

[0035] [Figure 11] This figure schematically shows a rear view of the reagent reaction section according to one embodiment of the present invention.

[0036] [Figure 12] This diagram schematically shows the structure of a dissolving solution distribution unit according to one embodiment of the present invention. [Figure 13] This diagram schematically shows the structure of a dissolving solution distribution unit according to one embodiment of the present invention.

[0037] [Figure 14] This diagram illustrates the process by which the dissolving solution is provided to each chamber in one embodiment of the present invention. [Figure 15] This diagram illustrates the process by which the dissolving solution is provided to each chamber in one embodiment of the present invention. [Figure 16] This diagram illustrates the process by which the dissolving solution is provided to each chamber in one embodiment of the present invention. [Modes for carrying out the invention]

[0038] Since the present invention can be modified in various ways and has various embodiments, specific embodiments will be illustrated and described in the drawings.

[0039] However, this should be understood not as limiting the present invention to any particular embodiment, but as including all modifications, equivalents, or substitutions that fall within the scope of the spirit and art of the present invention. Where it is determined that a specific description of the relevant prior art would obscure the gist of the present invention, such detailed description will be omitted.

[0040] Terms such as "first," "second," etc., can be used to describe various components, but components should not be limited by these terms. Terms are used solely to distinguish one component from another.

[0041] The terms used in this invention are used solely to describe specific embodiments and are not intended to limit the invention. Singular expressions include plural expressions unless the context clearly indicates otherwise.

[0042] In the present invention, terms such as “includes” or “having” are intended to specify the presence of features, numbers, steps, operations, components, parts, or combinations thereof as described in the specification, and should be understood not to preemptively exclude the possibility of the presence or addition of one or more other features, numbers, steps, operations, components, parts, or combinations thereof.

[0043] Therefore, the configurations shown in the embodiments described herein are merely one of the most preferred embodiments of the present invention and do not represent the entire technical concept of the present invention; there may be a variety of equivalents and modifications that can be substituted from the perspective of the present invention.

[0044] Furthermore, the accompanying drawings of this invention should be understood to have been enlarged or reduced for the sake of illustrative purposes.

[0045] The specimen testing apparatus and specimen testing method of the present invention will be described in detail below with reference to the attached drawings. However, the attached drawings are illustrative, and the scope of the specimen testing apparatus and specimen testing method of the present invention is not limited by the attached drawings.

[0046] A specimen testing apparatus 100 according to one embodiment of the present invention is a device that continuously performs various types of specimen reaction tests on a single specimen according to the wavelength of the test reagent 10 and the diagnostic beam. The specimen is collected from the human body and supplied to the test cartridge 300 in a state in which it has been mixed with a lysis solution contained in a vial container 200. Here, the lysis solution is a solution used to rupture cells, viruses, etc., and extract nucleic acids.

[0047] A specimen testing apparatus 100 according to one embodiment of the present invention includes a plurality of chambers each containing different test reagents, a specimen reaction unit 300 in which a dissolving solution mixed with a specimen is provided to each chamber and the specimen reacts with the test reagent; an optical unit 600 that moves sequentially along the arrangement direction of the plurality of chambers, irradiates each chamber with a diagnostic beam, and receives an optical signal from each chamber; and a diagnostic unit 700 in which a plurality of reaction data for a single specimen are acquired based on the optical signals corresponding to the wavelengths of the test reagent and the diagnostic beam, and the test result of the specimen is output based on the reaction data.

[0048] Referring to Figure 1, the specimen testing apparatus 100 according to one embodiment of the present invention includes a vial container 200, a testing cartridge 300, a heating unit 400, a heat dissipation unit 500, an optical unit 600, a diagnostic unit 700, and a code recognition unit 800.

[0049] The test cartridge 300 is designed to allow the sample to react with the test reagent 10. A vial container 200 is fitted into the test cartridge 300. The structure and function of the test cartridge 300 will be described later.

[0050] The vial container 200 contains the diluent mixed with the collected sample. The vial container 200 is coupled to the test cartridge 300 to supply the diluent to the test cartridge 300. The diluent is distributed to the respective chambers 311 to 318 provided in the test cartridge 300 and mixed with the test reagent 10 contained in the chambers.

[0051] On the other hand, the vial container 200 includes a container body and a container lid 220. The container body includes a solution storage section 211 in which the dissolving solution is contained and a perforated layer that closes the lower part of the solution storage section 211. The perforated layer is a thin film and is provided so as to be penetrated by the inlet 332 of the test cartridge 300. When the perforated layer is perforated by the inlet 332, the dissolving solution in the solution storage section 211 flows into the test cartridge 300.

[0052] The container lid 220 is detachably attached to the top of the container body 210. The container lid 220 is provided with a number of lid vents 221. Air flows into the solution storage section 211 through the lid vents 211.

[0053] In other words, the lid vent hole 211 brings the solution containment section 211 to an atmospheric pressure state. As a result, even without a separate drive device, the dissolving solution flows in the direction of gravity when the punching layer is punched.

[0054] Since various types of reagents can be used for the test reagent 10 depending on the purpose of testing the sample, the type of test reagent 10 is not particularly limited in this embodiment.

[0055] The test reagents 10 are housed in multiple chambers 311 to 318 provided in the test cartridge 300. Each chamber uses a different type of test reagent 10. The test reagents 10 are manufactured in bead form.

[0056] The test reagent 10 is prepared in the form of beads containing the test substance. Here, the test substance is a substance that reacts to a diagnostic beam B having a predetermined wavelength. The diagnostic beam B can have a fluorescence wavelength that is irradiated from the optical unit 600 to the inspection cartridge 300. Multiple test reagents are arranged to react to diagnostic beams of different wavelengths.

[0057] The heating unit 400 is located below the reagent reaction unit 310 and heats each of the chambers 311 to 318 to a pre-set temperature. The heating unit 400 is operated to maintain the chambers at an isothermal temperature, which is the pre-set temperature.

[0058] The heating unit 400 contacts the remaining area of ​​the chamber, excluding the light source injection sections 311a to 318a, and provides heat to the chamber. For example, the heating unit 400 can provide heat to the remaining three surfaces of the chamber other than the light source injection section.

[0059] The heat dissipation section 500 is connected to the heating section 400 to dissipate heat from the heating section 400. The heat dissipation section 500 includes heat dissipation fins 510 and a heat dissipation fan 520. The heat dissipation fan 520 is a fan that provides airflow to the heat dissipation fins 510. The heat dissipation fan 520 is installed on both sides of the heat dissipation fins 510.

[0060] The optical unit 600 is a device that irradiates each of the chambers 311 to 318 of the inspection cartridge 300 with diagnostic beam B, receives optical signals S from each of the chambers 311 to 318, and secures reaction data of the sample to the test reagent.

[0061] In this embodiment, the optical unit 610 of the optical unit 600 continuously acquires optical signals S corresponding to the arrangement order of the chambers while sequentially moving in the transport direction. Here, the transport direction is the direction parallel to the arrangement direction of the multiple chambers 311 to 318.

[0062] Referring to Figure 3, the optical unit 600 is installed on one side of the inspection cartridge 300 so that the diagnostic beam B is incident on the light source incident sections 311a to 318a. The optical unit 600 includes a plurality of optical units 610 and a transport unit 630.

[0063] The optical unit 610 is coupled to the transport unit 630 and moves sequentially according to the arrangement of the chambers, irradiating each of the chambers 311 to 318 with the diagnostic beam B and acquiring the optical signal S received from each chamber. The direction of irradiation of the diagnostic beam B is perpendicular to the transport direction of the optical unit.

[0064] Referring to Figure 5, the optical unit 610 may include a light source 611a, a first lens 611b, a beam splitter 611c, a second lens 611d, a third lens 611e, and a photodiode 611f.

[0065] The diagnostic beam B is incident from the light source 611a through the first lens 611b to the beam splitter 611c, reflected at a right angle of 90 degrees from the beam splitter 611c, focused by the second lens 611d, and incident on the light source incident sections 311a to 318a provided on one side of the chamber. The diagnostic beam B reflected from the chamber passes in a straight line through the second lens 611d and the beam splitter 611c, is focused by the third lens 611e, and is received as an optical signal S by the photodiode 611f.

[0066] In this embodiment, for the sake of convenience of explanation, the multiple optical units 610 are divided and referred to as "first optical unit 611 to fourth optical unit 614" according to their arrangement order.

[0067] The first optical units 611 to the fourth optical units 614 have the same structure except that they irradiate each other with diagnostic beams B of different wavelengths. As shown in Figures 4 and 6, the first optical units 611 to the fourth optical units 614 are arranged in a row.

[0068] The first optical unit 611 is an optical unit 610 that irradiates with the first diagnostic beam B. As shown in Figure 6(b), the first optical unit 611 is positioned by a transport unit so that the first diagnostic beam B is incident perpendicularly on the chamber, and moves sequentially along the transport direction according to the arrangement order of the multiple chambers 311 to 318, irradiating each of the chambers 311 to 318 with the first diagnostic beam B, and receiving the optical signal S with a photodiode 611f.

[0069] The second optical unit 612 is an optical unit 610 that irradiates the second diagnostic beam B. The second optical unit 612 is positioned alongside the first optical unit 611 in the direction of the chamber arrangement.

[0070] As shown in Figure 6(c), the second optical unit 612 is positioned by the transport unit so that the second diagnostic beam B is incident perpendicularly on the chamber, and is operated to irradiate each of the chambers 311 to 318 with the second diagnostic beam B while sequentially moving along the transport direction according to the arrangement order of the multiple chambers 311 to 318, and to receive the optical signal S.

[0071] The third optical unit 613 is an optical unit 610 that irradiates the third diagnostic beam B. The third optical unit 613 is positioned alongside the second optical unit 612 in the direction of the chamber arrangement.

[0072] As shown in Figure 6(d), the third optical unit 613 is positioned by the transport unit so that the third diagnostic beam B is incident perpendicularly on the chamber, and is operated to irradiate each of the chambers 311 to 318 with the third diagnostic beam B while moving sequentially along the transport direction according to the arrangement order of the multiple chambers 311 to 318, and to receive the optical signal S.

[0073] The fourth optical unit 614 is an optical unit 610 that irradiates the fourth diagnostic beam B. The fourth optical unit 614 is arranged in the alignment direction alongside the third optical unit 613.

[0074] As shown in Figure 6(e), the fourth optical unit 614 is positioned by a transport unit so that the fourth diagnostic beam B is incident perpendicularly on the chamber. It is operated to irradiate each of the chambers 311 to 318 with the fourth diagnostic beam B while sequentially moving along the transport direction according to the arrangement order of the chambers 311 to 318, and to receive the optical signal S.

[0075] In this embodiment, the first diagnostic beam B to the fourth diagnostic beam B have different fluorescence wavelengths. The fluorescence wavelengths include at least one selected from FAM, HEX, ROX, or Cy5.

[0076] FAM fluorescence wavelengths are emitted within the range of 510 nm to 530 nm. HEX fluorescence wavelengths are emitted within the range of 550 nm to 580 nm. ROX fluorescence wavelengths are emitted within the range of 595 nm to 635 nm. Cy5 fluorescence wavelengths are emitted within the range of 655 nm to 675 nm.

[0077] The transfer unit 630 is a device that is coupled to a plurality of optical units 610 and transfers the optical units 610.

[0078] The transfer unit 630 adjusts the position of one of the optical units so that the diagnostic beam B is perpendicularly irradiated into the first chamber in the chamber arrangement sequence, and then transfers one of the optical units at a pre-set transfer interval. Here, the transfer interval is the distance between the center of one of the chambers and the other chamber adjacent to it.

[0079] Referring to Figures 2 and 3, the transfer unit 630 includes a transfer rail 631, a transfer belt 633, a drive unit 634, a transfer member 635, and a chain member 636.

[0080] The transfer rail 631 is installed alongside the inspection cartridge 300 in the direction of the chamber arrangement. The transfer rail 631 is a rail that guides the movement of the transfer member 635.

[0081] The transfer belt 633 is installed alongside the transfer rail 631, spaced apart from the inspection cartridge 300. A drive unit 634 is installed on the transfer belt 633.

[0082] Referring to Figure 2, the drive unit 634 consists of a pair of drive pulleys 634a and a drive motor 634b. Here, the pair of drive pulleys 634a are rotatably mounted at both ends of the transfer belt 633.

[0083] One of the pair of drive pulleys 634a is coupled to the drive motor 634b. The drive pulley 634a transmits the rotational force of the drive motor 634b to the transfer belt 633 when the drive motor 634b is rotating. The other drive pulley 634a idles and guides the movement of the transfer belt 633.

[0084] A transfer member 635 is connected to the transfer belt 633. Multiple optical units 610 are connected to the upper end of the transfer member 635. The lower end 635a of the transfer member is connected to the transfer belt 633, but is also connected to the transfer rail 631 so that it can move along the transfer rail 631 when the transfer belt 633 is in operation. A chain member 636 is connected to the transfer member 635.

[0085] The chain member 636 is installed alongside the transport belt 633, spaced apart from the transport rail 631, and is connected to the transport member 635, guiding the movement of the transport member 635.

[0086] In this embodiment, the transfer unit 630 adjusts the position of the optical unit 610 while the transfer member 635 moves in the direction of movement of the transfer belt 633 when the drive motor 634b is operating.

[0087] For example, when the first optical unit 611 is in operation, the transfer unit 630 adjusts the position of the transfer member 635 so that the first diagnostic beam B of the first optical unit 611 is incident perpendicularly on each of the chambers 311 to 318, and then the transfer belt 633 moves by a predetermined distance and then stops for a predetermined time.

[0088] The movement interval of the transfer belt 633 is the distance between moving from one chamber to another adjacent chamber. The stopping time of the transfer belt 633 is the time between the irradiation of the first diagnostic beam B from the first optical unit 611 and the reception of the optical signal S for the first diagnostic beam B. This process proceeds sequentially according to the arrangement of the chambers.

[0089] Specifically, the diagnostic unit 700 acquires multiple reaction data for a single sample based on the optical signal S corresponding to the wavelength of the test reagent 10 and the diagnostic beam B, and predicts the test result of the sample based on the reaction data.

[0090] The diagnostic unit 700 has already set the chamber numbers and the names of the test reagents 10 contained in each of the chambers 311 to 318 according to the arrangement order of the chambers. The diagnostic unit 700 matches the code recognized by the code recognition unit 800 with the reaction data corresponding to the chamber number and outputs the test result.

[0091] Here, the code recognition unit 800 is a device that is positioned to recognize the code attached to the inspection cartridge 300 and recognizes the cartridge code 357 attached to the container mounting unit 350.

[0092] The following describes the test cartridge 300 in which the sample reacts with the test reagent 10, with reference to Figures 7 to 16.

[0093] Referring to Figures 7 to 9, the device includes a reagent reaction section 310, a gasket member 320, a dissolving solution distribution section 330, a filter member 340, and a container mounting section 350. The reagent reaction section 310, gasket member 320, dissolving solution distribution section 330, filter member 340, and container mounting section 350 are stacked sequentially in the upper and lower halves.

[0094] A vial container 200 is attached to the test cartridge 300. Here, the vial container 200 is a container that holds a diluent in which the sample has been mixed.

[0095] When the vial container 200 inserted into the container mounting section 350 is punctured by the inlet 332 of the dissolving solution distribution section 330, the dissolving solution flows from the vial container 200 through the inlet 332 in the direction of gravity into the channel section 333 of the dissolving solution distribution section 330, and flows down through the respective guide pins 334a to 334h provided in the channel section 333 into the respective chambers 311 to 318, where it is stored.

[0096] The reagent reaction section 310 includes a plurality of chambers 311 to 318. The plurality of chambers 311 to 318 are arranged in a line, spaced apart from each other.

[0097] Here, each of the chambers 311 to 318 contains a different test reagent 10. The chamber is the space in which the sample reacts with the test reagent 10.

[0098] Referring to Figure 11, the reagent reaction section 310 has multiple upper fitting grooves 319a on its upper edge and is fitted onto multiple upper fitting protrusions of the distribution plate 331.

[0099] The reagent reaction section 310 is provided with a plurality of side fitting grooves 319b arranged on both sides at intervals along the longitudinal direction, and the plurality of side fitting grooves 319b are arranged offset from the arrangement of the plurality of chambers 311 to 318. Here, the side fitting grooves 319b are grooves into which the fitting projections 351 of the container mounting section 350 are connected.

[0100] In this embodiment, for the sake of explanation, the multiple chambers 311 to 318 are referred to as "the first chamber 311 to the eighth chamber 318". Here, the first chamber 311 refers to the chamber that is the first in the arrangement order, and the eighth chamber 318 refers to the chamber that is the eighth in the arrangement order. However, the number of chambers is variable and is not limited to those described in this specification and drawings.

[0101] Each of the chambers 311 to 318 is provided with light source injection sections 311a to 318a that protrude laterally. In this embodiment, for the sake of explanation, the light source injection sections 311a to 318a are referred to as "first light source injection section 311a to eighth light source injection section 318a".

[0102] Between the reagent reaction section 310 and the container mounting section 350, a gasket member 320, a dissolving solution distribution section 330, and a filter member 340 are sequentially stacked.

[0103] The gasket member 320 is positioned on top of the reagent reaction section 310 so as to cover each of the chambers 311 to 318. In this case, it is desirable that the gasket member 320 is installed in the reagent reaction section 310 so as not to restrict the flow of the dissolving solution to each of the chambers 311 to 318.

[0104] For this purpose, the gasket member 320 is provided with a plurality of pinholes 321 and a plurality of gasket air holes 323 in the direction of arrangement of the plurality of chambers.

[0105] Here, the multiple pinholes 321 are holes through which each of the guide pins 334a to 334h can pass. The pinholes 321 are made larger than the cross-sectional area of ​​the guide pins.

[0106] The gasket air holes 323 are holes through which air passes. Multiple gasket air holes 323 are provided to correspond to each of the air holes 335a to 335h. The gasket air holes 323 are provided to communicate with each of the chambers 311 to 318. Each gasket air hole 323 is provided coaxially with each of the air holes 335a to 335h and each of the air grooves 331a to 331h to form an air passage.

[0107] Referring to Figures 12 and 13, the dissolving solution distribution section 330 includes a distribution plate 331, an inlet 332, a channel section 333, a plurality of guide pins 334a to 334h, and a plurality of air holes 335a to 335h.

[0108] The dissolving solution distribution unit 330 is inserted into the vial container 200 by penetrating the lower end of the vial container 200, and is supplied with the dissolving solution, which is then distributed to the respective chambers 311 to 318. The dissolving solution distribution unit 330 is laminated and coupled to the reagent reaction unit 310 such that its guide pins 334a to 334h are inserted into the respective chambers 311 to 318, and its air holes are connected to the respective chambers 311 to 318.

[0109] The distribution plate 331 has specifications corresponding to the reagent reaction section 310. The distribution plate 331 is provided with an inlet hole 332a that penetrates vertically through the center. An inlet section 332 is provided on the upper surface of the distribution plate 331, and a channel section 333 and a plurality of guide pins 334a to 334h are provided on the lower surface.

[0110] The distribution plate 331 is provided with a plurality of upper fitting protrusions 331i that protrude from the upper edge of the distribution plate 331 to the upper part of the distribution plate 331. The upper part of the distribution plate 331 is fitted into the container mounting part 350 by the upper fitting protrusions 331i.

[0111] The distribution plate 331 is provided with a plurality of lower fitting protrusions (not shown) that protrude from its lower edge to the lower part of the distribution plate 331. The lower part of the distribution plate 331 is fitted into the reagent reaction section 310 by these lower fitting protrusions.

[0112] Referring to Figures 8 and 9, the inlet 332 is provided coaxially with the inlet hole 332a and protrudes vertically from the upper part of the distribution plate 331, so as to be insertable into the vial container 200.

[0113] The inlet 332 has a pointed tip at its upper end. For example, the inlet 332 has a hollow column shape inside.

[0114] The inlet section 332 is provided with an inlet passage 332b and an inlet guide groove 332c. The inlet passage 332b runs vertically through the inlet hole 332a, coaxially with the center of the inlet hole 332a. The inlet passage 332b is the passage through which the dissolving solution flows from the vial container 200 to the channel section 333.

[0115] The inlet guide groove 332c is provided at the tip of the inlet 332. The inlet guide groove 332c guides the flow of the dissolving liquid into the inlet passage 332b. That is, the inlet guide groove 332c causes the dissolving liquid to flow into the inlet passage 332b not over the entire surface area of ​​the inclined surface of the inlet, but through the inlet guide groove 332c, which is provided in a narrow width on the inclined surface.

[0116] Referring to Figures 12 and 13, the channel section 333 is provided on the lower surface of the distribution plate 331. The channel section 333 guides the flow of the dissolving liquid that has flowed into the inlet hole 332a.

[0117] The channel section 333 consists of a reference channel 333a and a plurality of branch channels 333b1 to 333b8. Here, the reference channel 333a has a groove structure connected to the inlet hole 332a on the lower surface of the distribution plate 331. The plurality of branch channels 333b1 to 333b8 have groove structures that branch off from the reference channel 333a.

[0118] Multiple branch channels 333b1 to 333b8 branch off from the reference channel 333a symmetrically with respect to the inlet hole 332a. Multiple branch channels 333b1 to 333b8 are arranged to curve with a predetermined curvature in the direction away from the inlet hole 332a. Alternatively, branch channels 333b1 to 333b8 have an L-shaped structure that is gently bent in the direction away from the inlet hole 332a.

[0119] The multiple branch channels 333b1 to 333b8 are referred to as "the first branch channel 333b1 to the eighth branch channel 333b8".

[0120] Multiple guide pins 334a to 334h are provided so as to protrude vertically from the end of each branch channel 333b1 to 333b8 to the bottom of the distribution plate 331, corresponding to the arrangement of multiple chambers 311 to 318.

[0121] Guide pins 334a to 334h have a pin groove 334a-1 along the longitudinal direction of the guide pin on one side that connects to the branch channels 333b1 to 333b8, which guides the flow of the dissolving liquid flowing through each of the branch channels 333b1 to 333b8.

[0122] In this embodiment, for the sake of explanation, the multiple guide pins 334a to 334h are referred to as "first guide pin 334a to eighth guide pin 334h". The first guide pin 334a to eighth guide pin 334h have the same structure.

[0123] Here, the first guide pin 334a is provided so as to protrude from the end of the first branch channel 333b1 to the lower surface of the distribution plate 331. Referring to Figures 14 and 16, the first guide pin 334a is inserted into the first chamber 311 and guides the flow of the dissolution into the first chamber 311. In this process, the dissolution flows down into the first chamber 311 along the pin groove 334a-1 provided in the first guide pin 334a.

[0124] Referring to Figure 14, the second guide pin 334b ​​is provided so as to protrude from the end of the second branch channel 333b2 to the lower surface of the distribution plate 331. The second guide pin 334b ​​is inserted into the second chamber 312 to guide the flow of the dissolution into the second chamber 312.

[0125] The third guide pin 334c is provided so as to protrude from the end of the third branch channel 333b3 to the underside of the distribution plate 331. The third guide pin 334c is inserted into the third chamber 313 to guide the flow of the dissolution into the third chamber 313.

[0126] The fourth guide pin 334d is provided so as to protrude from the end of the fourth branch channel 333b4 to the lower surface of the distribution plate 331. The fourth guide pin 334d is inserted into the fourth chamber 314 to guide the flow of the dissolution into the fourth chamber 314.

[0127] The fifth guide pin 334e is provided so as to protrude from the end of the fifth branch channel 333b5 to the underside of the distribution plate 331. The fifth guide pin 334e is inserted into the fifth chamber 315 to guide the flow of the dissolution into the fifth chamber 315.

[0128] The sixth guide pin 334f is provided so as to protrude from the end of the sixth branch channel 333b6 to the underside of the distribution plate 331. The sixth guide pin 334f is inserted into the sixth chamber 316 and guides the flow of the dissolution into the sixth chamber 316.

[0129] The seventh guide pin 334g is positioned to protrude from the end of the seventh branch channel 333b7 to the underside of the distribution plate 331. The seventh guide pin 334g is inserted into the seventh chamber 317 and guides the flow of the dissolution into the seventh chamber 317.

[0130] The eighth guide pin 334h is provided so as to protrude from the end of the eighth branch channel 333b8 to the underside of the distribution plate 331. The eighth guide pin 334h is inserted into the eighth chamber 318 and guides the flow of the dissolution into the eighth chamber 318.

[0131] Multiple air holes 335a to 335h pass through the distribution plate 331 vertically, and are arranged to correspond to the arrangement of their respective guide pins 334a to 334h.

[0132] Each of the air holes 335a to 335h is located on the opposite side of the side where the pin groove 334a-1 is provided, and is positioned so as to be separated from the ends of each branch channel 333b1 to 333b8, with each of the guide pins 334a to 334h in between.

[0133] In this embodiment, for the sake of explanation, the multiple air holes are divided and referred to as "the first air hole 335a to the eighth air hole 335h".

[0134] The first air holes 335a to the eighth air holes 335h are arranged in a single line alongside the arrangement of the first guide pins 334a to the eighth guide pins 334h.

[0135] Referring to Figure 15, the first air hole 335a is aligned with the first guide pin 334a. Similarly, the second air holes 335b to the eighth air holes 335h are aligned with the second guide pins 335b to the eighth guide pins 335h, respectively.

[0136] Here, the first air hole 335a communicates with the first chamber 311 and guides the airflow into the first chamber 311. The first air hole 335a is positioned on the opposite side of the pin groove 334a-1 and spaced apart from the first guide pin 334a.

[0137] The second air hole 335b communicates with the second chamber 312 and guides the airflow into the second chamber 312. The third air hole 335c communicates with the third chamber 313 and guides the airflow into the third chamber 313. The fourth air hole 335d communicates with the fourth chamber 314 and guides the airflow into the fourth chamber 314.

[0138] The fifth air hole 335e communicates with the fifth chamber 315 and guides the airflow into the fifth chamber 315. The sixth air hole 335f communicates with the sixth chamber 316 and guides the airflow into the sixth chamber 316.

[0139] The seventh air hole 335g communicates with the seventh chamber 317 and guides the airflow to the seventh chamber 317. The eighth air hole 335h communicates with the eighth chamber 318 and guides the airflow to the eighth chamber 318.

[0140] The distribution plate 331 is provided with a plurality of air grooves 331a to 331h, each having a diameter larger than the diameter of the respective air hole and arranged to correspond to the arrangement of the air holes.

[0141] In this embodiment, for the sake of explanation, the multiple air grooves 331a to 331h are referred to as "the first air groove 331a to the eighth air groove 331h".

[0142] Referring to Figure 9, the filter projections 341 of the filter member 340 are inserted into the first air groove 331a to the eighth air groove 331h, respectively.

[0143] A first air hole 335a is provided in the first air groove 331a. The first air hole 335a is an opening that penetrates the bottom surface of the first air groove 331a vertically. The first air groove 331a is provided with a diameter larger than the diameter of the first air hole 335a.

[0144] Similarly, the second air groove 331b to the eighth air groove 331h are provided with the second air hole 335b to the eighth air hole 335h, respectively.

[0145] The first air holes 335a to the eighth air holes 335h are covered by a filter member 340 inserted into the first air grooves 331a to the eighth air grooves 331h. The filter member 340 allows air to pass through but filters out other foreign matter from entering the air holes. The filter member 340 is provided with a plurality of filter protrusions 341 protruding from one side.

[0146] Multiple filter protrusions 341 are provided so as to be insertable into the first air groove 331a to the eighth air groove 331h. The multiple filter protrusions 341 are inserted into the first air groove 331a to the eighth air groove 331h, respectively, and cover the respective air holes.

[0147] The container mounting section 350 is into which a vial container 200 containing a diluent in which the sample has been mixed is inserted. The container mounting section 350 is provided with a container insertion space 353, a plurality of hooks 355 and a plurality of fitting protrusions 351, and a cartridge cord 357.

[0148] Referring to Figure 8, the container insertion space 353 is the space into which the vial container 200 is inserted.

[0149] Multiple hooks 355 are provided in the container insertion space 353 so as to protrude inward from the container insertion space 353. The hooks 355 are inserted into the vial container 200 to prevent the vial container 200 from coming out of the container insertion space 353.

[0150] Cartridge code 375 is the section that lists the code name of the test cartridge 300 in which the test reagent 10 is administered.

[0151] The multiple fitting protrusions 351 are projections that protrude vertically from the lower part of the container mounting section 350. The multiple fitting protrusions 351 are fitted into the side fitting grooves 319b of the reagent reaction section 310. In this way, the container mounting section 350 is coupled to the reagent reaction section 310. The container mounting section 350 and the reagent reaction section 310 are coupled so that they are stacked vertically.

[0152] When the vial container 200 is inserted into the container insertion space 353, the container mounting section 350 uses the hook 355 to support the side of the vial container 200, stably holding the vial container so that the dissolving solution inside the vial container 200 flows in the direction of gravity.

[0153] As the dissolving solution flows into the chambers, the container mounting section 350 stably holds the vial container 200, prevents the vial container 200 from shaking, and ensures that the dissolving solution flows uniformly into each of the chambers 311 to 318.

[0154] The following describes the process of continuously testing samples using the present invention.

[0155] The vial container 200 is inserted into the container mounting section 350. The perforated layer at the bottom of the vial container 200 is perforated by the inlet 332 of the dissolving solution distribution section 330. As a result, the dissolving solution inside the vial container 200 flows through the inlet 332 to the flow path section 333. At this time, the flow of the dissolving solution proceeds in the direction of gravity.

[0156] The dissolving solution branches into multiple branch channels 333b1 to 333b8 of the channel section 333, and flows into the chamber via the pin grooves 334a-1 of the respective guide pins 334a to 334h provided at the end of each branch channel 333b1 to 333b8.

[0157] For example, the dissolving solution flows through the first guide pin 334a of the dissolving solution distribution unit 330 to the first chamber 311. The first air hole 335a of the dissolving solution distribution unit 330 communicates with the gasket air hole 323 and is connected to the first chamber 311.

[0158] As air flows into the first chamber 311 through the first air hole 335a and the gasket air hole 323, the first chamber 311 is affected by gravity. As a result, the dissolving solution flows down the first guide pin 334a in the direction of gravity into the first chamber 311. At this point, the dissolving solution is in a mixed state with the sample.

[0159] In the first chamber 311, the sample in the dissolving solution is mixed with the first test reagent 10 contained in the first chamber 311. For the sample reaction between the sample and the first test reagent 10, the first chamber 311 is kept isothermally at a temperature suitable for the chemical reaction. The first chamber 311 is heated to a predetermined temperature by the heating unit 400.

[0160] The first chamber 311 contains the first test reagent 10. The second to eighth chambers 312 to 318 contain the second to eighth test reagents 10, respectively. The first to eighth test reagents 10 use different types of reagents.

[0161] After a set time has elapsed, the first optical unit 611 moves sequentially along the direction of the chamber arrangement at a movement interval between chambers.

[0162] Specifically, the first optical unit 611 is positioned by the transfer unit 630 so that the first diagnostic beam B is incident perpendicularly toward the first light source incident section 311a of the first chamber 311. Subsequently, the first optical unit 611 directs the first diagnostic beam B toward the first light source incident section 311a of the first chamber 311 and receives the optical signal S reflected from the first light source incident section 311a.

[0163] Next, the first optical unit 611 is moved by the transfer unit 630 to a position where the first diagnostic beam B is incident perpendicularly on the second light source injection section 312a of the first chamber 311. The distance traveled by the first optical unit 611 is the distance between the first chamber 311 and the second chamber 312. The first optical unit 611 provides the first diagnostic beam B to the second light source injection section 312a and receives the optical signal S reflected from the second light source injection section 312a.

[0164] The above process is repeated as the first optical unit 611 moves sequentially from the first chamber 311 to the eighth chamber 318. As a result, the first optical unit acquires eight optical signals S for the first chamber 311 to the eighth chamber 318.

[0165] Once the operation of the first optical unit 611 is complete, the transfer unit 630 adjusts the position of the second optical unit 612 so that it irradiates the first light source incident section 311a of the first chamber 311 with the second diagnostic beam B. The second optical unit 612 also moves sequentially along the transfer direction, acquiring eight optical signals S for the first chamber 311 to the eighth chamber 318. The same process is carried out for the third optical unit 613 and the fourth optical unit 614.

[0166] Through the process described above, an optical signal S can be obtained for each wavelength of the diagnostic beam B in relation to the first test reagent 10.

[0167] For example, when two optical units, the first optical unit 611 and the second optical unit 612, acquire two optical signals S for the first chamber 311, the diagnostic unit 700 can calculate the test result for the first test reagent 10 through the two optical signals S corresponding to the wavelengths of their respective diagnostic beams B, namely, the optical signal S acquired by the first optical unit 611 in the first chamber 311 and the optical signal S acquired by the second optical unit 612 in the first chamber 311.

[0168] Alternatively, when three optical signals S are obtained for the first chamber 311 by the first optical unit 611 to the third optical unit 613, the diagnostic unit 700 can calculate the test result for the first test reagent 10 through the three optical signals S, each corresponding to the wavelength of the diagnostic beam B.

[0169] As a result, the present invention allows for the continuous irradiation of multiple test reagents 10 with diagnostic beams B of different wavelengths, the continuous acquisition of optical signals S for each test reagent 10 corresponding to the wavelength of each diagnostic beam B, and thereby the calculation of the test results for each test reagent 10 of the sample.

[0170] As a result, the present invention allows various tests to be performed continuously in a single flow under the same conditions using a sample collected once, preventing contamination of the collected sample and improving the accuracy and speed of the tests.

[0171] The preferred embodiments of the present invention described above are disclosed for illustrative purposes only, and a person skilled in the art with ordinary skill in the invention will know that various modifications, alterations, and additions are possible within the spirit and scope of the invention, and such modifications, alterations, and additions should be considered to fall within the scope of the claims below. [Industrial applicability]

[0172] According to at least one embodiment of the specimen testing apparatus of the present invention, various types of specimen reaction tests can be performed sequentially on a single specimen according to the wavelength of the test reagent and diagnostic beam, thereby improving the speed and efficiency of the specimen testing.

Claims

1. A sample reaction unit comprising a plurality of chambers, each containing a different test reagent, wherein a dissolving solution containing a sample is provided in each chamber, and the sample reacts with the test reagent; An optical unit that sequentially moves along the arrangement direction of the plurality of chambers, irradiates each of the chambers with a diagnostic beam, and receives optical signals from each of the chambers; and The diagnostic unit includes a diagnostic unit that acquires multiple reaction data for a single sample based on the test reagent and the optical signal corresponding to the wavelength of the diagnostic beam, and outputs the test result for the sample based on the reaction data. The aforementioned sample reaction unit is A container mounting section into which a vial containing the dissolved solution mixed with the aforementioned sample is inserted; A reagent reaction section in which the plurality of chambers are arranged in a line and spaced apart; A dissolving solution distribution unit that penetrates the lower end of the vial container, is inserted into the vial container, is supplied with the dissolving solution, and distributes the dissolving solution to each of the chambers; and A specimen testing apparatus comprising a gasket member, which is stacked between the dissolving solution distribution unit and the reagent reaction unit and covers each of the chambers, but is provided to allow air to flow through the chambers.

2. Each of the aforementioned chambers is provided with a light source inlet that protrudes laterally. The specimen inspection apparatus according to claim 1, wherein the optical unit injects the diagnostic beam into the light source incidence unit.

3. The aforementioned optical unit is A transfer unit installed alongside the sample reaction unit; and The specimen testing apparatus according to claim 1, further comprising: a plurality of optical units coupled to the transfer unit, which sequentially move along the arrangement direction of the chambers, irradiating each of the chambers with the diagnostic beam and acquiring the optical signal received for each of the chambers.

4. The aforementioned plurality of optical units A first optical unit that irradiates with a first diagnostic beam; and The system includes a second optical unit, which is positioned alongside the first optical unit and irradiates a second diagnostic beam, The specimen testing apparatus according to claim 3, wherein the first diagnostic beam and the second diagnostic beam have different fluorescence wavelengths.

5. The fluorescence wavelength includes at least one selected from FAM, HEX, ROX, or Cy5. The FAM fluorescence wavelength has an emission wavelength in the range of 510 nm to 530 nm. The HEX fluorescence wavelength has an emission wavelength in the range of 550 nm to 580 nm. The ROX fluorescence wavelength has an emission wavelength in the range of 595 nm to 635 nm. The specimen testing apparatus according to claim 4, wherein the Cy5 fluorescence wavelength has an emission wavelength in the range of 655 nm to 675 nm.

6. The first optical unit moves sequentially along the arrangement direction of the multiple chambers, irradiating each of the chambers with the first diagnostic beam, and acquiring an optical signal for the first diagnostic beam for each chamber. The specimen testing apparatus according to claim 4, wherein the second optical unit moves sequentially along the arrangement direction of a plurality of chambers, irradiating each of the chambers with the second diagnostic beam, and acquiring an optical signal for the second diagnostic beam for each chamber.

7. The plurality of optical units further include a third optical unit that is arranged alongside the second optical unit along the arrangement direction of the chamber and irradiates a third diagnostic beam, The specimen testing apparatus according to claim 4, wherein the third diagnostic beam has a different wavelength from the first diagnostic beam and the second diagnostic beam.

8. The specimen testing apparatus according to claim 7, wherein the third optical unit moves sequentially along the arrangement direction of a plurality of chambers, irradiating each of the chambers with the third diagnostic beam, and acquiring an optical signal for the third diagnostic beam for each chamber.

9. The plurality of optical units further include a fourth optical unit that is arranged alongside the third optical unit in the direction of arrangement of the chamber and irradiates a fourth diagnostic beam, The specimen testing apparatus according to claim 7, wherein the fourth diagnostic beam has a wavelength different from that of the first to third diagnostic beams.

10. The specimen testing apparatus according to claim 9, wherein the fourth optical unit moves sequentially along the arrangement direction of a plurality of chambers, irradiating each of the chambers with the fourth diagnostic beam, and acquiring an optical signal for the fourth diagnostic beam for each chamber.

11. The transfer unit is A transfer rail is installed in line with the sample reaction section in the direction of the arrangement of multiple chambers, A transfer belt is installed at a distance from the sample reaction unit so as to be parallel to the transfer rail, A drive unit including a pair of drive pulleys installed at both ends of the transfer belt and a drive motor that provides rotational force to one of the drive pulleys, The upper end is connected to the plurality of optical units, and the lower end is connected to the transport belt, but when the transport belt is in operation, the transport member is connected to the transport rail so as to be movable along the transport rail, The specimen inspection apparatus according to claim 3, further comprising a chain member installed spaced apart from the transport belt with the transport rail in between, and coupled to the transport member to guide the movement of the transport member.

12. The specimen testing apparatus according to claim 1, wherein the gasket member is provided such that guide pins for guiding the flow of the dissolving liquid pass through the chamber.

13. A heating unit that provides heat from the lower part of the reagent reaction unit to each of the chambers and operates so that each of the chambers is kept isothermally at a pre-set temperature; and The specimen testing apparatus according to claim 12, further comprising a heat dissipation unit coupled to the heating unit for dissipating heat from the heating unit.

14. The aforementioned dissolving solution distribution unit is A distribution plate provided to correspond to the reagent reaction section, with an inlet hole that penetrates vertically through the center; An inlet portion provided coaxially with the inlet hole and projecting vertically from the upper part of the distribution plate, and designed to be insertable into the vial container; A channel section comprising a reference channel connected to the inlet hole on the lower surface of the distribution plate, and a plurality of branch channels branching off from the reference channel, for guiding the flow of the dissolving liquid that flows into the inlet hole; Multiple guide pins provided so as to protrude vertically from the end of each of the branch channels to the lower part of the distribution plate, corresponding to the arrangement of the multiple chambers; and Multiple air holes are provided that penetrate the distribution plate vertically, and are arranged to correspond to the arrangement of each of the guide pins. The specimen testing apparatus according to claim 12, wherein the dissolving solution distribution unit is laminated and coupled to the reagent reaction unit such that each of the guide pins is inserted into each of the chambers and each of the air holes is connected to each of the chambers.

15. The specimen testing apparatus according to claim 14, wherein the guide pin has a pin groove along the longitudinal direction of the guide pin on one surface connected to the branch channel, to guide the flow of the dissolving solution flowing through the branch channel.

16. The specimen testing apparatus according to claim 14, wherein each of the aforementioned air holes is provided on the opposite side of the surface where the pin groove is provided, and is spaced apart from the end of the branch channel, with each of the aforementioned guide pins in between.

17. The specimen testing apparatus according to claim 14, wherein the multiple branching channels are provided symmetrically with respect to the inlet hole, branching from the reference channel and curving with a predetermined curvature in a direction away from the inlet hole.

18. The distribution plate is provided with a plurality of air grooves, each having a diameter larger than the diameter of the respective air hole, and arranged to correspond to the arrangement of the respective air holes. The specimen testing apparatus according to claim 14, further comprising a filter member having a plurality of filter protrusions inserted into each of the air grooves and covering each of the air holes.

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