Two-phase separated liquid oral composition

Abstract

To provide a two-phase separation type liquid oral composition that allows for easy emulsification when shaken and easy separation after standing.SOLUTION: A two-phase separation type liquid oral composition includes (A) rice bran oil, (B) liquid paraffin, (C) vegetable oil with an unsaponifiable material content of 4 mass% or less, and (D) water. The mass ratio of the content of (C) vegetable oil to the content of (A) rice bran oil [(C) / (A)] is 0.5 or more. The mass ratio of the combined content of (A) rice bran oil and (C) vegetable oil to the content of (B) liquid paraffin [[(A)+(C)] / (B)] is 1.0 or more.SELECTED DRAWING: None

Description

Technical Field

[0001] The present invention relates to a two-phase separation type liquid oral composition.

Background Art

[0002] As disclosed in Patent Document 1, there is known a two-phase separation type liquid oral composition which is a liquid composition that separates into two phases, an oil layer and an aqueous layer, when left standing, and is used in a state where an emulsion is temporarily formed by shaking.

Prior Art Documents

Patent Documents

[0003]

Patent Document 1

Summary of the Invention

Problems to be Solved by the Invention

[0004] In the two-phase separation type liquid oral composition as disclosed in Patent Document 1, while it is required to maintain the state where an emulsion is formed during use, it is preferably quickly returned to the state of separating into two phases again when left standing after use in terms of appearance. That is, it is required to improve these characteristics while achieving both ease of emulsification by shaking and ease of separation after standing.

Means for Solving the Problems

[0005] The gist of the two-phase separation type liquid oral composition for solving the above problems is that it contains (A) rice bran oil, (B) liquid paraffin, (C) vegetable oil other than (A) rice bran oil having an unsaponifiable matter content of 4% by mass or less, and (D) water, wherein the mass ratio of the content of (C) vegetable oil to the content of (A) rice bran oil [(C) / (A)] is 0.5 or more, and the mass ratio of the total content of (A) rice bran oil and (C) vegetable oil to the content of (B) liquid paraffin [[(A)+(C)] / (B)] is 1.0 or more.

[0006] In the above two-phase separated liquid oral composition, it is preferable that the (C) vegetable oil has a plant sterol content of 0.2% or less. The above two-phase separated liquid oral composition preferably does not contain lower alcohols. [Effects of the Invention]

[0007] The two-phase separation type liquid oral composition of the present invention makes it possible to achieve both ease of emulsification by shaking and ease of separation after standing. [Modes for carrying out the invention]

[0008] The following describes one embodiment of a two-phase separated liquid oral composition. The two-phase separated liquid oral composition of this embodiment contains (A) rice bran oil, (B) liquid paraffin, (C) vegetable oil other than (A) rice bran oil having an unsaponifiable matter content of 4% by mass or less, and (D) water. The mass ratio of the content of (C) vegetable oil to the content of (A) rice bran oil [(C) / (A)] is 0.5 or more. The mass ratio of the total content of (A) rice bran oil and (C) vegetable oil to the content of (B) liquid paraffin [[(A)+(C)] / (B)] is 1.0 or more.

[0009] By containing the above-mentioned components in the above-mentioned mass ratio, the two-phase separation type liquid oral composition can achieve both ease of emulsification by shaking and ease of separation after standing. In the following, the two-phase separation type liquid oral composition may be abbreviated as "oral composition." The oral composition is a liquid composition that separates into two phases, an aqueous layer and an oil layer, when left standing. When the oral composition is shaken, the two phases mix and form an emulsion. When the oral composition in the emulsion state is left standing, the oral composition returns to a state where it has separated into two phases again. The oral composition can repeatedly change between a separated state and an emulsified state by repeating shaking and standing. The oral composition is, for example, a mouthwash used by holding it in the mouth. It is preferable to use the oral composition in the state in which the emulsion has formed.

[0010] Shaking here refers to the operation of shaking the container containing the oral composition up and down a predetermined number of times at a speed of, for example, twice per second. An example of a predetermined number of shakes is 30 times. Separation into two phases, a water layer and an oil layer, means that the oral composition can be visually observed to be separated into approximately two phases. For example, there may be a dispersion layer of fine, milky white water and oil particles at the boundary between the two phases, which is visually different from the oil and water layers. It is preferable that such a dispersion layer accounts for 5% or less of the total volume of the combined oil and water layers.

[0011] Furthermore, the term "unsaponifiable matter" refers to lipid-soluble components that are not saponified when vegetable oil is reacted with an alkali to produce fatty acid salts (soap) in a saponification reaction. Unsaponifiable matter in vegetable oils generally contains plant sterols.

[0012] <(A) Rice bran oil> Rice bran oil is contained in the oil layer of the oral composition, which is in a separated state. Rice bran oil is not particularly limited as long as it is an oil obtained by extracting from rice bran. The method of extracting rice bran oil is not particularly limited, but methods such as solvent extraction and pressing can be used.

[0013] The oral composition may contain one type of rice bran oil alone, or it may contain a combination of two or more types of rice bran oil. Commercially available rice bran oil can be used.

[0014] The content of rice bran oil in the oral composition is not particularly limited, but is, for example, 1.0% by mass or more and 20% by mass or less. Hereinafter, the content of each component in the oral composition may be expressed with "%" instead of "% by mass". The upper limit of the above content is preferably 15%, more preferably 10%. The lower limit of the above content is preferably 4%, more preferably 8%. Furthermore, the upper or lower limit within this range may be, for example, 2, 3, 4, 5, 6, 7, 8, 9, 10, 12, 14, 16, or 18%.

[0015] <(B) Liquid paraffin> Liquid paraffin is contained in the oil layer of the oral composition in a separated state. Liquid paraffin refers to a mixture of chain-type saturated hydrocarbons having approximately 15 to 35 carbon atoms.

[0016] The type of liquid paraffin contained in the oral composition is not particularly limited, but for example, the oral composition has a kinematic viscosity of 4.0 mm at 40°C. 2 / s or more 40.0mm 2 It is preferable that the liquid paraffin has a viscosity of 0.0 / s or less. The upper limit of the kinematic viscosity is preferably 20.0, and more preferably 15.0. The lower limit of the kinematic viscosity is preferably 9.0, and more preferably 12.0. The kinematic viscosity at 40°C can be measured using a known viscometer.

[0017] For example, the oral composition has a density of 0.80 g / cm³ at 15°C. 3 More than 0.90g / cm 3It preferably contains liquid paraffin. The upper limit value of the above density is preferably 0.88, more preferably 0.85. The lower limit value of the above density is preferably 0.83, more preferably 0.84.

[0018] For example, the oral composition preferably contains liquid paraffin having a number average molecular weight (Mn) of 280 or more and 400 or less. The upper limit value of the above number average molecular weight (Mn) is preferably 370, more preferably 340. The lower limit value of the above number average molecular weight (Mn) is preferably 300, more preferably 320.

[0019] The method for measuring the above number average molecular weight (Mn) is not particularly limited. For example, it can be measured using gel permeation chromatography (GPC). Specifically, the measurement of the number average molecular weight (Mn) can be performed under the following conditions. From the measurement results, the number average molecular weight (Mn) can be determined based on a calibration curve obtained by a primary approximation using commercially available monodisperse polystyrene.

[0020] Apparatus: 150-C ALC / GPC manufactured by Waters Detector: RI detector Mobile phase: o-dichlorobenzene (for high performance liquid chromatography) Sample concentration: 1% solution Flow rate: 1.0 mL / min Column: One AT-807S manufactured by Showa Denko K.K. and two TSK-gel GMH-H6 manufactured by Tosoh Corporation are connected in series Column temperature: 140 °C Injection volume: 0.5 mL The oral composition may contain one type of liquid paraffin alone or may contain a combination of two or more types of liquid paraffin. Commercially available liquid paraffin can be used as the liquid paraffin.

[0021] The content of liquid paraffin in the oral composition is not particularly limited, but is, for example, 2% to 25%. The upper limit of the above content is preferably 20%, more preferably 15%. The lower limit of the above content is preferably 6%, more preferably 10%. The upper or lower limit within this range may also be, for example, 3, 4, 5, 6, 7, 8, 9, 10, 12, 14, 16, 18, 20, 22, or 24%.

[0022] <(C) Vegetable oil> The vegetable oil is contained in the oil layer of the oral composition, which is in a separated state. The vegetable oil is not particularly limited as long as the unsaponifiable matter content is 4% by mass or less. Preferably, it is a vegetable oil with a plant sterol (also called phytosterol) content of 0.2% or less. Examples of vegetable oils include olive oil and avocado oil.

[0023] Olive oil is a fatty oil obtained by pressing the fruit of Olea europaea L. (Oleaceae). For example, the unsaponifiable matter content in olive oil is 1.5% or less. For example, the plant sterol content in the unsaponifiable matter contained in olive oil is 0.2% or less.

[0024] Avocado oil is a fatty oil obtained from the fruit of the crocodile pear (Persea americana Mill., Persea gratissima CFGaertn., or Lauraceae). For example, the unsaponifiable matter content in avocado oil is 4% or less. For example, the plant sterol content in the unsaponifiable matter contained in avocado oil is 0.1% or less.

[0025] The oral composition may contain one type of vegetable oil alone, or it may contain a combination of two or more types of vegetable oils. When two or more types of vegetable oils are combined, the content of unsaponifiable matter relative to the total vegetable oils should be 4% by mass or less. Commercially available vegetable oils can be used. For example, vegetable oils for food or cosmetics can be used.

[0026] The content of vegetable oil in the oral composition is not particularly limited, but is, for example, 4% to 30%. The upper limit of the above content is preferably 20%, more preferably 10%. The lower limit of the above content is preferably 5%, more preferably 7%. The upper or lower limit within this range may also be, for example, 6, 8, 10, 12, 14, 16, 18, 20, 22, 24, 26, or 28%.

[0027] <Oil layer> In oral compositions, the mass ratio of the content of (C) vegetable oil to the content of (A) rice bran oil [(C) / (A)] is 0.5 or higher. For example, the above mass ratio [(C) / (A)] is 0.5 or more and 10.0 or less. The upper limit of the above mass ratio [(C) / (A)] is preferably 6.0, and more preferably 2.0. The lower limit of the above mass ratio [(C) / (A)] is preferably 1.0, and more preferably 1.5. Furthermore, the upper or lower limit within this range may be, for example, 1.0, 1.5, 2.0, 2.5, 3.0, 3.5, 4.0, 4.5, 5.0, 5.5, 6.0, 6.5, 7.0, 7.5, 8.0, 8.5, 9.0, or 9.5.

[0028] In the oral composition, the mass ratio of the total content of (A) rice bran oil and (C) vegetable oil to the content of (B) liquid paraffin [[(A)+(C)] / (B)] is 1.0 or greater. For example, the above mass ratio [[(A)+(C)] / (B)] is 1.0 or greater and 10.0 or less. The upper limit of the above mass ratio [[(A)+(C)] / (B)] is preferably 6.0, and more preferably 2.0. The lower limit of the above mass ratio [[(A)+(C)] / (B)] is preferably 1.3, and more preferably 1.6. Furthermore, the upper or lower limit within this range may be, for example, 1.0, 1.5, 2.0, 2.5, 3.0, 3.5, 4.0, 4.5, 5.0, 5.5, 6.0, 6.5, 7.0, 7.5, 8.0, 8.5, 9.0, or 9.5.

[0029] The oil layer content in the oral composition is not particularly limited, but is, for example, 5% to 50%. The upper limit of the above content is preferably 40%, more preferably 30%. The lower limit of the above content is preferably 10%, more preferably 20%. The upper or lower limit within this range may also be, for example, 10%, 15%, 20%, 25%, 30%, 35%, 40%, or 45%.

[0030] In addition to the components (A), (B), and (C) above, the oral composition may also contain known oil-soluble components. These oil-soluble components can be added in amounts that do not impair the effects of the oral composition. Each of the oil-soluble components listed below may be used individually or in combination of two or more.

[0031] Examples of oil-soluble components include fragrances, oil-soluble colorants, and oil-soluble active ingredients. Fragrance ingredients include, for example, menthol, anethole, eugenol, camphor, citronellol, 1,8-cineole, cinnamic aldehyde, thymol, vanillyl butyl ether, vanillin, phenethyl alcohol, heliotropin, borneol, methyl salicylate, p-menthane-3,8-diol, menthyl lactonate, linalool, limonene, ocimene, n-decyl alcohol, α-terpineol, methyl acetate, citronellyl acetate, Examples of fragrances include methyl eugenol, ethyl linalool, vanillin, spearmint oil, peppermint oil, lemon oil, orange oil, grapefruit oil, bergamot oil, lime oil, sage oil, thyme oil, rosemary oil, laurel oil, cinnamon oil, pimento oil, perilla oil, eucalyptus oil, anise oil, wintergreen oil, cassia oil, clove oil, cardamom oil, coriander oil, mandarin oil, caraway oil, bay oil, lemongrass oil, pine needle oil, and neroli oil. In addition, flavorings such as apple, apricot, strawberry, cherry, pineapple, peach, banana, and melon can be used. Natural fragrances such as orange blossom can also be used.

[0032] Examples of oil-soluble colorants include oil-soluble dyes such as Red No. 215, Red No. 225, Yellow No. 201, Yellow No. 204, Green No. 202, and Violet No. 201. Known oil-soluble natural pigments can also be used as oil-soluble colorants.

[0033] Examples of oil-soluble active ingredients include triclosan, isopropylmethylphenol, hinokitiol, tocopherol, tocotrienol, tocopherol acetate, tocopherol nicotinate, and ibuprofen.

[0034] <Water layer> (D) The type of water used as component is not particularly limited, but for example, distilled water, pure water, ultrapure water, purified water, tap water, etc. can be used.

[0035] The oral composition may contain (D) water, as well as known water-soluble components. These water-soluble components can be added insofar as they do not impair the effects of the oral composition. For example, an oral composition may contain a lower alcohol such as ethanol. "Lower alcohol" refers to an alcohol with 5 or fewer carbon atoms. Lower alcohols such as ethanol are likely to cause irritation to users of oral compositions. Therefore, the amount of lower alcohol in an oral composition is preferably small, for example, 5% by mass or less, more preferably 3% by mass or less, and most preferably 0% by mass. Here, 0% by mass means that it is acceptable to include it at an impurity level.

[0036] Other water-soluble components include humectants, preservatives, viscosity modifiers, sweeteners, water-soluble colorants, pH adjusters, water-soluble fragrances, and water-soluble active ingredients. Each of the water-soluble components listed below may be used individually or in combination of two or more.

[0037] Examples of humectants include sugar alcohols such as sorbitol, xylitol, maltitol, and erythritol, and polyhydric alcohols such as glycerin, propylene glycol, polyethylene glycol, hexylene glycol, and butylene glycol.

[0038] Examples of preservatives include para-hydroxybenzoic acid esters such as methylparaben, and sodium benzoate. Examples of viscosity modifiers include cellulose derivatives such as sodium carboxymethylcellulose, hydroxyethylcellulose, hydroxypropylcellulose, and hydroxypropylmethylcellulose; gums such as propylene glycol alginate, xanthan gum, tragacanth gum, karaya gum, arabic gum, carrageenan, and guar gum; and synthetic binders such as polyvinyl alcohol, sodium polyacrylate, carboxyvinyl polymer, and polyvinylpyrrolidone.

[0039] Examples of sweetening ingredients include xylitol, stevia extract, sodium saccharin, aspartame, sucralose, and acesulfame K. Examples of water-soluble colorants include water-soluble pigments such as Red No. 2, Red No. 3, Red No. 102, Red No. 106, Yellow No. 4, Yellow No. 5, Orange No. 205, Blue No. 1, Green No. 3, and Green No. 201. Known water-soluble natural pigments can also be used as water-soluble colorants.

[0040] Examples of pH adjusting agents include phosphoric acid, malic acid, tartaric acid, citric acid, and their water-soluble salts. It is preferable that the oral composition has a pH of 6.0 to 8.5 at 25°C.

[0041] Examples of water-soluble active ingredients include fluorides such as sodium fluoride, sodium monofluorophosphate, and tin fluoride; enzymes such as epsilon-aminocaproic acid, dextranase, and mutanase; tranexamic acid, allantoin chlorohydroxyaluminum, hinokitiol, sodium lauroyl sarcosinate, ascorbic acid, dihydrocholesterol, α-bisabolol, chlorhexidine salts, azulene, dipotassium glycyrrhizinate, sodium copper chlorophyllin, chlorophyll, copper compounds such as copper gluconate, aluminum lactate, strontium chloride, potassium nitrate, berberine, zinc citrate, Phellodendron amurense extract, and extracts of chamomile, clove, rosemary, scutellaria baicalensis, and safflower.

[0042] The oral composition may contain known surfactants as other components, but the surfactant content is preferably small, and more preferably zero. <Container> Any container commonly used for filling oral compositions may be used, such as a plastic container. Suitable plastic container materials include polyethylene terephthalate, polyethylene, acrylonitrile styrene, and polypropylene. Other containers include glass containers.

[0043] The container used to fill the oral composition is preferably one in which the contents can be seen from the outside. For example, the container used to fill the oral composition is preferably transparent or translucent, and more preferably colorless and transparent.

[0044] <Mechanism and Effects> The operation of this embodiment will now be described. The oral composition of this embodiment further contains, in addition to rice bran oil, a vegetable oil having an unsaponifiable matter content of 4% or less. More specifically, the oral composition of this embodiment contains a vegetable oil having an unsaponifiable matter content of 4% or less in a predetermined ratio relative to the content of rice bran oil and liquid paraffin. Generally, the unsaponifiable matter content in rice bran oil is about 5% to 10%. Therefore, compared to a form in which rice bran oil and liquid paraffin are blended but no vegetable oil with an unsaponifiable matter content of 4% or less is blended, the unsaponifiable matter content in this embodiment is relatively smaller. That is, in the oil layer of the oral composition of this embodiment, the mass ratio of the unsaponifiable matter content to the total oil layer is relatively small.

[0045] Here, the plant sterols contained in the unsaponifiable matter are known as natural emulsifiers. In other words, the unsaponifiable matter is an emulsifying component. In this embodiment, the oral composition contains a relatively small mass ratio of unsaponifiable matter, which tends to reduce the emulsifying effect derived from the unsaponifiable matter. As a result, the oil layer and the water layer tend to separate into two phases.

[0046] The effects of this embodiment will now be explained. (1) The oral composition can be easily mixed by shaking, with the aqueous layer and oil layer forming a temporary emulsion. By applying this oral composition to the oral cavity, both the effects of the components contained in the aqueous layer and the effects of the components contained in the oil layer can be obtained.

[0047] (2) With the oral composition, when the oral composition in the emulsion state is left standing, it quickly returns to a state of separation into two phases. Therefore, when the oral composition is not in use, the user can maintain a good appearance of the oral composition separated into two phases, an aqueous layer and an oil layer.

[0048] (3) In the case of oral compositions, when the oral composition is left standing, less oil droplet adheres to the wall surface of the container in which the oral composition is filled. That is, the appearance of the two phases separated into a water layer and an oil layer is good.

[0049] (4) For example, it has been conventionally known that when a composition having two phases, an aqueous layer and an oil layer, contains a lower alcohol such as ethanol, the ease of separating the two phases is improved. It is also well known that lower alcohols such as ethanol can cause irritation. For this reason, while compositions containing lower alcohols such as ethanol improve the ease of separation, they can cause irritation to the user.

[0050] In this respect, the oral composition of this embodiment allows for easy separation of the two phases, the aqueous layer and the oil layer, even when it does not contain lower alcohols such as ethanol. In other words, it is possible to ensure easy separation of the aqueous layer and the oil layer while reducing the irritation felt in the oral cavity when using the oral composition.

[0051] (5) The oral composition contains rice bran oil. Rice bran oil contains, for example, fatty acids that have antibacterial properties. That is, the oral composition can exert antibacterial activity derived from rice bran oil. The oral composition contains rice bran oil that exerts such antibacterial activity, and when shaken, it forms an emulsion, and when left standing, it can be easily separated into two phases. [Examples]

[0052] The two-phase separation type liquid oral composition will be described in more detail based on the following examples. Note that the two-phase separation type liquid oral composition is not limited to the configurations described in the Examples section.

[0053] The oral compositions of Examples 1-9 shown in Table 1 and Comparative Examples 1-11 shown in Table 2 were prepared by mixing and stirring each component according to conventional methods. Commercially available olive oil and avocado oil were used, with unsaponifiable matter content of 1.5% by mass or less and 4% by mass or less, respectively, and plant sterol content of 0.2% or less and 0.1% or less, respectively. The liquid paraffin had a kinematic viscosity of 12.56 mmHg at 40°C. 2 / s, density 0.843 g / cm³ 3 A substance with a number-average molecular weight (Mn) of 323 was used. In Tables 1 and 2, the values ​​listed to the right of each component represent the content (mass %) in the oral composition.

[0054] [Table 1]

[0055] [Table 2] (Evaluation test) For Examples 1-9 and Comparative Examples 1-11, the separation surface, wall surface oil droplet adhesion, and separation time were evaluated. The evaluation methods and criteria are shown below.

[0056] <Evaluation of the separation surface> For each oral composition in Examples 1-9 and Comparative Examples 1-11, emulsions were formed by shaking, and then allowed to stand for 5 days. Afterward, the appearance of each composition was visually evaluated. The evaluation was performed by five evaluators. The evaluation with the majority of votes was considered the final evaluation. The results are shown in Tables 1 and 2.

[0057] • Evaluation criteria ○ (Good): There is no cloudy layer at the separation surface between the water and oil layers. ×(Unacceptable): There is a cloudy white layer at the separation surface between the water layer and the oil layer.

[0058] <Evaluation of oil droplet adhesion on wall surfaces> For each oral composition in Examples 1-9 and Comparative Examples 1-11, emulsions were formed by shaking, and then allowed to stand for 5 days. Afterward, the appearance of each oral composition was visually evaluated. The evaluation was performed by five evaluators. The evaluation with the majority of votes was considered the final evaluation. The results are shown in Tables 1 and 2.

[0059] • Evaluation criteria ○ (Good): No oil droplets larger than 5 mm in diameter are adhering to the container walls. × (Unacceptable): Oil droplets larger than 5 mm in diameter are adhering to the container wall.

[0060] <Evaluation of separation time> For each oral composition in Examples 1-9 and Comparative Examples 1-11, emulsions were formed by shaking, and then allowed to stand for 5 days. After that, the mixtures were shaken 30 times up and down at a rate of 2 times per second, and then allowed to stand again. The time until the separation of the two phases, the aqueous layer and the oil layer, could be visually confirmed after standing was measured. The evaluation was performed by five evaluators. The average of the five evaluators' scores was calculated as the final evaluation value. The results are shown in Tables 1 and 2.

[0061] <Overall Rating> The overall evaluation was conducted based on the following criteria. ○ (Good): Both the evaluation of the separation surface and the evaluation of oil droplet adhesion to the wall surface are good, and the separation time is within 180 minutes.

[0062] × (Not acceptable): At least one of the evaluations of the separation surface and the wall surface oil droplet adhesion is unacceptable. Or, the separation time is longer than 180 minutes. (Evaluation results) As shown in Table 1, the evaluation of the separation surface and the evaluation of oil droplet adhesion to the wall surface were good in Examples 1 to 9. In other words, it can be seen that Examples 1 to 9 have a good appearance when separated into two phases, the aqueous layer and the oil layer.

[0063] In Examples 1-9, the separation time was within 180 minutes. That is, in Examples 1-9, even after forming an emulsion by shaking, the mixture returned to a two-phase state consisting of an aqueous layer and an oil layer after 180 minutes of standing.

[0064] On the other hand, Comparative Example 1, which did not contain (C) vegetable oil, showed a cloudy layer on the separation surface and had a long separation time. Comparative Examples 2 to 5, which contained (C) vegetable oil but had a mass ratio [(C) / (A)] of less than 0.5 and a mass ratio [[(A)+(C)] / (B)] of less than 1.0, could not be evaluated on the separation surface. Comparative Example 6, which did not contain (A) rice bran oil or (C) vegetable oil, showed a good evaluation of the separation surface, but oil droplets were observed adhering to the walls of the container. Comparative Examples 7 to 11, which did not contain (B) liquid paraffin, showed a cloudy layer on the separation surface.

[0065] From the above results, it can be seen that in Examples 1 to 9, an emulsion can be easily formed when shaken, and the two phases can be easily separated when left standing.

[0066] These effects are obtained by the following composition: an oral composition containing (A) rice bran oil, (B) liquid paraffin, (C) vegetable oil having an unsaponifiable matter content of 4% by mass or less, and (D) water. In the above oral composition, the mass ratio of the content of (C) vegetable oil to the content of (A) rice bran oil [(C) / (A)] is 0.5 or more. Furthermore, in the above oral composition, the mass ratio of the total content of (A) rice bran oil and (C) vegetable oil to the content of (B) liquid paraffin [[(A)+(C)] / (B)] is 1.0 or more.

[0067] Furthermore, since Examples 1 to 9 contain rice bran oil, antibacterial effects derived from rice bran oil can be expected. (Example prescription) Table 3 shows examples of formulations for two-phase separated liquid oral compositions.

[0068] In Table 3, the values ​​listed to the right of each component represent the content (mass%) in the two-phase separation type liquid oral composition.

[0069] [Table 3] (Reagent details) The details of the reagents used in each test described in the Examples section are as follows:

[0070] Rice bran oil: "Sunblanc Rice Oil (Cold-Pressed Rice Bran Oil)", Sanwa Oil Co., Ltd. Liquid paraffin: "Moresco White P-70", MORESCO Corporation

Claims

1. (A) Rice bran oil and (B) Liquid paraffin and (A) A vegetable oil other than rice bran oil, (C) a vegetable oil having an unsaponifiable matter content of 4% by mass or less, (D) Contains water and The mass ratio of the content of (C) vegetable oil to the content of (A) rice bran oil [(C) / (A)] is 0.5 or more. The mass ratio of the total content of (A) rice bran oil and (C) vegetable oil to the content of (B) liquid paraffin [[(A) + (C)] / (B)] is 1.0 or greater. Two-phase separation type liquid oral composition.

2. The aforementioned (C) vegetable oil has a plant sterol content of 0.2% or less. The two-phase separated liquid oral composition according to claim 1.

3. Does not contain lower alcohols The two-phase separated liquid oral composition according to claim 1 or 2.

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