Collaborative optimization of radionuclides and external beam radiotherapy

JP7863330B2Active Publication Date: 2026-05-21REFLEXION MEDICAL INC
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Patent Information

Authority / Receiving Office
JP · JP
Patent Type
Patents
Current Assignee / Owner
REFLEXION MEDICAL INC
Filing Date
2021-01-26
Publication Date
2026-05-21

AI Technical Summary

Technical Problem

Existing radiotherapy methods fail to provide uniform radiation doses to tumors, especially for larger tumors, leading to potential recurrence at the tumor edges due to heterogeneous dose distribution, and may cause toxicity to healthy tissues from nonspecific radionuclide uptake.

Method used

A method for creating a combined radiotherapy treatment plan that jointly optimizes the radiation doses from internal and external therapeutic sources, using functional imaging data to calculate and adjust doses to achieve a biologically equivalent cumulative dose that meets predetermined requirements, ensuring uniformity and minimizing toxicity.

Benefits of technology

The method achieves a more uniform radiation dose distribution across the tumor, reducing the risk of recurrence and minimizing toxicity to healthy tissues by synergistically combining internal and external radiotherapy modalities.

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Patent Text Reader

Abstract

Disclosed herein is a method for optimizing radiation therapy treatment plans for irradiating one or more target regions using both an internal therapeutic radiation source (ITRS) and an external therapeutic radiation source (ETRS). One variation of the method involves iterating ITRS and ETRS radiation dose values ​​to achieve a cumulative dose that meets predetermined dose requirements. In some variations, the ITRS is an injectable compound having a targeting backbone and a radionuclide, and images acquired using an imaging compound having the same targeting backbone as the injectable compound can be used to calculate the radiation dose deliverable using the injectable ITRS and also to calculate an emission filter for delivering radiation using a biologically guided radiation therapy (BGRT) system. Image data acquired from previous treatment sessions can be used to adapt the dose provided by the ITRS and / or ETRS for future treatment sessions.
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