Methods and systems for multidimensional imaging

JP7863544B2Active Publication Date: 2026-05-21SINGULAR GENOMICS SYSTEMS INC
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Patent Information

Authority / Receiving Office
JP · JP
Patent Type
Patents
Current Assignee / Owner
SINGULAR GENOMICS SYSTEMS INC
Filing Date
2021-09-13
Publication Date
2026-05-21

AI Technical Summary

Technical Problem

Conventional light-sheet fluorescence microscopy (LSFM) systems are difficult to implement due to the need for two orthogonal objective lenses, complex alignment procedures, and high data processing requirements, limiting their application in space-constrained environments and causing photodamage to samples.

Method used

A multi-depth confocal imaging system that uses oblique illumination and simultaneous multi-depth imaging without high-NA immersion lenses, integrating confocal excitation and observation to achieve high-capacity imaging without spatial limitations.

Benefits of technology

The system enables efficient, high-capacity 3D imaging at multiple depths, reducing photodamage and eliminating the need for high-NA lenses, suitable for various sample types and environments.

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Abstract

The multi-depth confocal imaging system includes at least one light source configured to provide an excitation beam and an objective lens, the excitation beam being focused through the objective lens into the sample at a first plurality of focal depths along an excitation direction, and an image sensor receiving radiation from the sample through the objective lens, the radiation defining a focal point on the image sensor at a second plurality of focal depths.
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